…entral.com/1471-2229/12/235 RESEARCH ARTICLE Open Access Endo-(1,4)-β-Glucanase gene families in the grasses: temporal and spatial Co-transcription of orthologous genes1 Margaret Buchanan1, Rachel A Burton1, Kanwarpal S Dhugga2, Antoni J Rafalski3, Scott V Tingey3, Neil J Shirley…
…ionally, organoids offer widespread applications in cancer biology, such as oncogene modeling, therapeutic evaluation, and precision medicine, due to their ability to be derived from both normal and tumor tissues of cancer patients. By replicating the therapeutic vulnerabilities …
…A makes RNA makes proteins, but there is considerable uncertainty regarding the general, genome-wide correlation between levels of RNA and corresponding proteins. Therefore, to assess degrees of this correlation we compared the RNA profiles (determined using both cDNA- and oligo-…
…siological changes occurring with advancing pregnancy. Thus, parturition can be generally viewed as four complementary phenotypes, based on the timing and presence of labor: delivery in women at term with labor (TL), delivery at term without labor (TNL), delivery after preterm la…
…sR stress response regulons was observed. This included increased expression of genes associated with staphyloxanthin synthesis, which has been linked to membrane stabilisation. Similarly, up-regulation of genes involved in capsule formation was recorded as were significant chang…
…lysis of DeepMAPS takes the raw counts matrices of multiple scRNA-seq (multiple gene expression matrices), CITE-seq (gene and surface protein expressions matrices), and scRNA-ATAC-seq (gene expression and chromatin accessibility matrices) data as input. For each data matrix, we d…
…lidation of individual models on corresponding treatment arms from patient data generated in the BATTLE clinical trial. A Partial Least Squares Regression (PLSR) based modeling framework was designed and implemented, using a special splitting strategy and canonical pathways to ca…
Abstract It is known that genetic variants can affect gene expression, but it is not yet completely clear through what mechanisms genetic variation mediate this expression. We therefore compared the cis -effect of single nucleotide polymorphisms (SNPs) on gene expression between …
Computational Neurogenetic Modeling TOPICS IN BIOMEDICAL ENGINEERING INTERNATIONAL BOOK SERIES Series Editor: Evangelia Micheli-Tzanakou Rutgers University Piscataway, New Jersey Signals and Systems in Biomedical Engineering: Signal Processing and Physiological Systems Modeling S…
…ster and C. elegans using modENCODE RNA-seq data. We focus on “stage-associated genes” that capture specific transcriptional activities in each stage and use them to map pairwise stages within and between the two species by a hypergeometric test. Within each species, temporally a…
…stract The development of late-onset Alzheimer’s disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer’s disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has…
…species origins and divergence, the nature of human/plant interactions, and the genetic basis of domestication. Moreover, an understanding of the evolutionary history of crop species aids genetic mapping approaches, as well as informs plant breeding strategies. Within the genus O…
… complex geography of domestication of the African rice Oryza glaberrima . PLoS Genet 15(3): e1007414. https://doi.org/10.1371/journal.pgen.1007414 Editor: Jeffrey Ross-Ibarra, University of California Davis, UNITED STATES Received: May 10, 2018; Accepted: February 8, 2019; Publi…
…ee (21/NW/0157). The UKBB is a biomedical database with detailed phenotypic and genetic data from over 500,000 UK individuals aged 40–69 at recruitment 58 . In this study, we focused on the largest ancestry subset (that is, the White British population) of 29,661 unrelated indivi…
Index entries on this page f oo 1 Brain, Gene, a 60. Brain, Gene, and Quantum Inspired Computational Intelligence Pr Nikola Kasabov 60.2.1 Local, Knowledge-Based Learning This chapter discusses opportunities and challenges Evolving Connectionist Systems – for the creation of meth…