…pressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). Gain- and loss-of-function experiments demonstrate that changes in H2be expressi…

…lysis of DeepMAPS takes the raw counts matrices of multiple scRNA-seq (multiple gene expression matrices), CITE-seq (gene and surface protein expressions matrices), and scRNA-ATAC-seq (gene expression and chromatin accessibility matrices) data as input. For each data matrix, we d…

…lidation of individual models on corresponding treatment arms from patient data generated in the BATTLE clinical trial. A Partial Least Squares Regression (PLSR) based modeling framework was designed and implemented, using a special splitting strategy and canonical pathways to ca…

…ster and C. elegans using modENCODE RNA-seq data. We focus on “stage-associated genes” that capture specific transcriptional activities in each stage and use them to map pairwise stages within and between the two species by a hypergeometric test. Within each species, temporally a…

… complex geography of domestication of the African rice Oryza glaberrima . PLoS Genet 15(3): e1007414. https://doi.org/10.1371/journal.pgen.1007414 Editor: Jeffrey Ross-Ibarra, University of California Davis, UNITED STATES Received: May 10, 2018; Accepted: February 8, 2019; Publi…

…ee (21/NW/0157). The UKBB is a biomedical database with detailed phenotypic and genetic data from over 500,000 UK individuals aged 40–69 at recruitment 58 . In this study, we focused on the largest ancestry subset (that is, the White British population) of 29,661 unrelated indivi…

…ape of single vascular cells. The alternative text for this image may have been generated using AI. Single-cell RNA seq (scRNAseq) and single-cell ATAC seq (scATACseq) was performed on vascular tissue in adult healthy mice C57Bl/6) in three vascular sites (aortic root/ascending a…

…provides graph signal transform and seven downstream tasks: SVG identification, gene expression imputation, protein signal denoising, spatial domain characterization, cell type annotation, cell-spot alignment, and subcellular landmark inference. The detailed theoretical foundatio…

…ed by deep sequencing 4 – 8 . Functional interpretation is then performed using gene-based tools developed in the wake of the preceding microarray revolution 9 – 11 . In a typical analysis, one compares the total fraction of genes annotated for a given ontology term with the frac…

…ore RNA-Seq (Aug18) rlog Rat HSNIH-Palmer 859 EPFL/LISP BXD CD Liver Affy Mouse Gene 1.0 ST (Aug18) RMA Mouse BXD 858 EPFL/LISP BXD HFD Liver Affy Mouse Gene 1.0 ST (Aug18) RMA Mouse BXD 857 EPFL/LISP BXD CD+HFD Liver Affy Mouse Gene 1.0 ST (Aug18) RMA Mouse BXD 856 NIA Aging BXD…

REPORT FROM ATLANTA Gene Tyndall was formally inducted into the Global Institute of Logistics ‘Hall of Fame’. Kieran Ring, CEO of GIL, presented Gene Tyndall with the Waterford Crystal Claret Jug, in honour of his remarkable contributions to the industry. Many of Gene’s friends a…

…. Scientists study how molecules interact to drive biological processes such as gene regulation, signal transduction, and enzymology. Their work involves delineating the properties of molecules, molecular complexes, and cells; using chemistry tools to manipulate disease mechanism…

… is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hematopoietic…

…depth study is currently available that has investigated genome-wide changes in gene expression during the normal physiological fasting-feeding cycle in nutrient-sensitive and -insensitive mice. Using two strains of mice, C57BL/6J and BALB/cJ, and deploying deep RNA-Seq complemen…

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