Computational Neurogenetic Modeling TOPICS IN BIOMEDICAL ENGINEERING INTERNATIONAL BOOK SERIES Series Editor: Evangelia Micheli-Tzanakou Rutgers University Piscataway, New Jersey Signals and Systems in Biomedical Engineering: Signal Processing and Physiological Systems Modeling S…

…ster and C. elegans using modENCODE RNA-seq data. We focus on “stage-associated genes” that capture specific transcriptional activities in each stage and use them to map pairwise stages within and between the two species by a hypergeometric test. Within each species, temporally a…

…stract The development of late-onset Alzheimer’s disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer’s disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has…

… complex geography of domestication of the African rice Oryza glaberrima . PLoS Genet 15(3): e1007414. https://doi.org/10.1371/journal.pgen.1007414 Editor: Jeffrey Ross-Ibarra, University of California Davis, UNITED STATES Received: May 10, 2018; Accepted: February 8, 2019; Publi…

…ee (21/NW/0157). The UKBB is a biomedical database with detailed phenotypic and genetic data from over 500,000 UK individuals aged 40–69 at recruitment 58 . In this study, we focused on the largest ancestry subset (that is, the White British population) of 29,661 unrelated indivi…

… are used to treat infections caused by Gram- negative bacteria, but resistance genes emerged. Only scarce studies investigated the association between plasmid-mediated quinolone resistance (PMQR) genes and integrons in clinical isolates of E. coli. The current study investigated…

Abstract Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studies have investigated …

…d throughout the eukaryotic domain, and its initial discovery as a conserved epigenetic mark of active transcription from yeast to mammalian cells has led to the histone code hypothesis. However, recent studies have raised questions on whether the different forms of H3K4me play a…

…neuroscience ( Cajal, 1911 ). This advance is analogous to the insight that the gene is the unit of operation in genetics and molecular biology ( Morgan, 1911 ; Beadle and Tatum, 1941 ; Benzer, 1955 ; Jacob and Monod, 1961 ). However, studying individual genes is insufficient to …

…ape of single vascular cells. The alternative text for this image may have been generated using AI. Single-cell RNA seq (scRNAseq) and single-cell ATAC seq (scATACseq) was performed on vascular tissue in adult healthy mice C57Bl/6) in three vascular sites (aortic root/ascending a…

…atory of Agro-Animal Genomics and Molecular Breeding, Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, College of Animal Science of South China Agricultural University, Guangzhou 510642, P.R. China 2 Agricultural College, Guangdong Ocean Uni…

…provides graph signal transform and seven downstream tasks: SVG identification, gene expression imputation, protein signal denoising, spatial domain characterization, cell type annotation, cell-spot alignment, and subcellular landmark inference. The detailed theoretical foundatio…

Frontiers | Distinct gene signatures define the epithelial cell features of mucinous appendiceal neoplasms and pseudomyxoma metastases ORIGINAL RESEARCH article Front. Genet. , 13 February 2025 Sec. Cancer Genetics and Oncogenomics Volume 16 - 2025 | https://doi.org/10.3389/fgene…

…the genome to create specific sequence modifications is a powerful way to study gene function and promises future applicability to gene therapy. Creation of precise modifications requires homologous recombination, a very rare event in most cell types that can be stimulated by int…

…a researchers and curators at FlyBase have produced high-quality, comprehensive gene annotations for D. melanogaster based on a large amount of genetic and sequencing data. 18 Our protocol utilizes the gene annotations from D. melanogaster (reference species) to facilitate annota…