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Multi-layered transcriptional control of glycogen metabolism coordinates thermogenic remodeling of white adipocytes in male mice. Nat Commun. 2025 Dec 16; 17(1):809. Fu H, Lee S, Zemke NR, Fan W, Wang Y, Garza J, Tin D, Villao B, Zhang B, Ma X, Zhang J, Dong T, Ren Y, Downes M, Evans RM, Ren B, Saltiel AR. PMID: 41402325; PMCID: PMC12824187.
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Neutrophils preserve energy storage in sympathetically activated adipocytes. Nature. 2026 Feb; 650(8102):718-726. Son S, Xu C, Fu H, Wisessaowapak C, Valentine JM, An G, Jang J, Dinh M, Dai Y, Fan W, Yu RT, Downes M, Ying W, Skorobogatko Y, Evans RM, Saltiel AR. PMID: 41372404.
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Tank-Binding Kinase 1 protects against MASH progression via mitochondrial quality control. Res Sq. 2025 Oct 09. Huh JY, An SM, Jang JH, Sung JH, Myung JW, Jeon YG, Lee WT, Jeon JW, Yim KM, Lee JH, Zhang B, Seo JB, Im SS, Kim JB, Saltiel A. PMID: 41282122; PMCID: PMC12632721.
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Protocol for differentiating murine 3T3-L1 and SVF-derived preadipocytes and isolating crude mitochondrial fractions. STAR Protoc. 2025 Sep 19; 6(3):104045. Wisessaowapak C, Lee J, Kim H, Son S, Feng X, Chang L, Hoang A, Chen H, Bedsted S, Saltiel AR. PMID: 40849911; PMCID: PMC12398810.
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Hepatic glycogen directly regulates gluconeogenesis through an AMPK/CRTC2 axis in mice. J Clin Invest. 2025 Jun 02; 135(11). Zhang B, Johnson MM, Yuan T, Nguyen TN, Okada J, Yang F, Xiaoli AM, Melikian LH, Xu S, Dadpey B, Pessin JE, Saltiel AR. PMID: 40454488; PMCID: PMC12126231.
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Sympathetic activation of white adipose tissue recruits neutrophils to limit energy expenditure. Res Sq. 2025 Apr 16. Son S, Xu C, Jang J, Dinh M, Skorobogatko Y, Fu H, Valentine JM, An G, Ying W, Yu RT, Downes M, Evans RM, Saltiel AR. PMID: 40321773; PMCID: PMC12047989.
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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation. Nat Metab. 2024 Feb; 6(2):273-289. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. PMID: 38286821; PMCID: PMC10896723.
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Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes. Res Sq. 2023 Jun 02. Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu R, Downes M, Evans R, Ryden M, Wabitsch M, Reilly S, Huang J, Saltiel A. PMID: 37398165; PMCID: PMC10312969.
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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 06 06; 35(6):1009-1021.e9. Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. PMID: 37084733; PMCID: PMC10430883.
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The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis. JCI Insight. 2022 09 08; 7(17). Zhao P, Sun X, Liao Z, Yu H, Li D, Shen Z, Glass CK, Witztum JL, Saltiel AR. PMID: 35917178; PMCID: PMC9536260.
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Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome. Cell Rep. 2022 07 05; 40(1):111008. Dantas Machado AC, Brown SD, Lingaraju A, Sivaganesh V, Martino C, Chaix A, Zhao P, Pinto AFM, Chang MW, Richter RA, Saghatelian A, Saltiel AR, Knight R, Panda S, Zarrinpar A. PMID: 35793637; PMCID: PMC9296000.
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β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. J Clin Invest. 2022 01 18; 132(2). Valentine JM, Ahmadian M, Keinan O, Abu-Odeh M, Zhao P, Zhou X, Keller MP, Gao H, Yu RT, Liddle C, Downes M, Zhang J, Lusis AJ, Attie AD, Evans RM, Rydén M, Saltiel AR. PMID: 34847077; PMCID: PMC8759781.
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p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes. JCI Insight. 2022 01 11; 7(1). Martins VF, LaBarge SA, Stanley A, Svensson K, Hung CW, Keinan O, Ciaraldi TP, Banoian D, Park JE, Ha C, Hetrick B, Meyer GA, Philp A, David LL, Henry RR, Aslan JE, Saltiel AR, McCurdy CE, Schenk S. PMID: 34813504; PMCID: PMC8765050.
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Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease. Exp Mol Med. 2021 11; 53(11):1697-1705. Huh JY, Saltiel AR. PMID: 34848839; PMCID: PMC8639992.
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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature. 2021 11; 599(7884):296-301. Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. PMID: 34707293; PMCID: PMC9186421.
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Chop/Ddit3 depletion in β cells alleviates ER stress and corrects hepatic steatosis in mice. Sci Transl Med. 2021 07 28; 13(604). Yong J, Parekh VS, Reilly SM, Nayak J, Chen Z, Lebeaupin C, Jang I, Zhang J, Prakash TP, Sun H, Murray S, Guo S, Ayala JE, Satin LS, Saltiel AR, Kaufman RJ. PMID: 34321322; PMCID: PMC8557800.
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FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes. Cell Rep. 2021 06 29; 35(13):109331. Abu-Odeh M, Zhang Y, Reilly SM, Ebadat N, Keinan O, Valentine JM, Hafezi-Bakhtiari M, Ashayer H, Mamoun L, Zhou X, Zhang J, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Kliewer SA, Mangelsdorf DJ, Saltiel AR. PMID: 34192547; PMCID: PMC8293281.
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FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition. J Clin Invest. 2021 05 17; 131(10). Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. PMID: 33822771; PMCID: PMC8121507.
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NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ. Nat Commun. 2021 05 17; 12(1):2876. Huang J, Linares JF, Duran A, Xia W, Saltiel AR, Müller TD, Diaz-Meco MT, Moscat J. PMID: 34001883; PMCID: PMC8129077.
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Voices: Insulin and beyond. Cell Metab. 2021 04 06; 33(4):692-699. Roth J, Ashcroft FM, Wollheim CB, Kieffer TJ, Cherrington AD, Bergman RN, Taylor R, Najjar SM, Pedersen O, Ellingsgaard H, Holst JJ, Nauck MA, Kadowaki T, Czech MP, Corvera S, Saltiel AR, Corkey BE, Atkinson MA. PMID: 33826910.
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Insulin signaling in health and disease. J Clin Invest. 2021 01 04; 131(1). Saltiel AR. PMID: 33393497; PMCID: PMC7773347.
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TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation. Cell Metab. 2020 12 01; 32(6):1012-1027.e7. Huh JY, Reilly SM, Abu-Odeh M, Murphy AN, Mahata SK, Zhang J, Cho Y, Seo JB, Hung CW, Green CR, Metallo CM, Saltiel AR. PMID: 33152322; PMCID: PMC7710607.
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Interaction of Adipocyte Metabolic and Immune Functions Through TBK1. Front Immunol. 2020; 11:592949. Zhao P, Saltiel AR. PMID: 33193441; PMCID: PMC7606291.
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From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases. J Biol Chem. 2020 08 21; 295(34):12279-12289. Zhao P, Saltiel AR. PMID: 32651233; PMCID: PMC7443502.
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Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 07; 2(7):620-634. Reilly SM, Hung CW, Ahmadian M, Zhao P, Keinan O, Gomez AV, DeLuca JH, Dadpey B, Lu D, Zaid J, Poirier B, Peng X, Yu RT, Downes M, Liddle C, Evans RM, Murphy AN, Saltiel AR. PMID: 32694788; PMCID: PMC7384260.
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An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science. 2020 02 07; 367(6478):652-660. Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. PMID: 32029622; PMCID: PMC8012106.
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Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities. Am J Hum Genet. 2020 02 06; 106(2):246-255. Wagner M, Skorobogatko Y, Pode-Shakked B, Powell CM, Alhaddad B, Seibt A, Barel O, Heimer G, Hoffmann C, Demmer LA, Perilla-Young Y, Remke M, Wieczorek D, Navaratnarajah T, Lichtner P, Klee D, Shamseldin HE, Al Mutairi F, Mayatepek E, Strom T, Meitinger T, Alkuraya FS, Anikster Y, Saltiel AR, Distelmaier F. PMID: 32004447; PMCID: PMC7010976.
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IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
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Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Cell Metab. 2020 01 07; 31(1):189-206.e8. Sun X, Seidman JS, Zhao P, Troutman TD, Spann NJ, Que X, Zhou F, Liao Z, Pasillas M, Yang X, Magida JA, Kisseleva T, Brenner DA, Downes M, Evans RM, Saltiel AR, Tsimikas S, Glass CK, Witztum JL. PMID: 31761566; PMCID: PMC7028360.
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YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Proc Natl Acad Sci U S A. 2019 07 23; 116(30):15184-15193. Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B. PMID: 31289229; PMCID: PMC6660779.
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Hyaluronan as a potential thermogenic rheostat. Nat Metab. 2019 05; 1(5):503-504. Gordts PLSM, Saltiel AR. PMID: 32694849.
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Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes. J Labelled Comp Radiopharm. 2019 05 15; 62(5):202-208. Gan X, Wilson MW, Beyett TS, Wen B, Sun D, Larsen SD, Tesmer JJG, Saltiel AR, Showalter HD. PMID: 30828860; PMCID: PMC6525014.
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Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity. Bioorg Med Chem. 2018 11 01; 26(20):5443-5461. Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD. PMID: 30270002; PMCID: PMC6252132.
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ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. 2018 09 20; 175(1):133-145.e15. Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. PMID: 30220454; PMCID: PMC6159928.
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Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition. Mol Pharmacol. 2018 10; 94(4):1210-1219. Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG. PMID: 30082428; PMCID: PMC6128810.
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RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Proc Natl Acad Sci U S A. 2018 07 24; 115(30):7819-7824. Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. PMID: 29915037; PMCID: PMC6065037.
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Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation. Hepatology. 2018 10; 68(4):1331-1346. Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH. PMID: 29251796; PMCID: PMC6005718.
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ERRγ Preserves Brown Fat Innate Thermogenic Activity. Cell Rep. 2018 03 13; 22(11):2849-2859. Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. PMID: 29539415; PMCID: PMC5884669.
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TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue. Cell. 2018 02 08; 172(4):731-743.e12. Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR. PMID: 29425491; PMCID: PMC5808582.
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Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation. J Cell Sci. 2017 Oct 15; 130(20):3517-3531. Ichikawa T, Kita M, Matsui TS, Nagasato AI, Araki T, Chiang SH, Sezaki T, Kimura Y, Ueda K, Deguchi S, Saltiel AR, Kioka N. PMID: 28864765; PMCID: PMC5665443.
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Creatine Fuels the Thermic Effect of Feeding. Cell Metab. 2017 Oct 03; 26(4):594-595. Saltiel AR. PMID: 28844879.
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Adapting to obesity with adipose tissue inflammation. Nat Rev Endocrinol. 2017 Nov; 13(11):633-643. Reilly SM, Saltiel AR. PMID: 28799554.
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Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes. Cell Metab. 2017 Jul 05; 26(1):157-170.e7. Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. PMID: 28683283; PMCID: PMC5663294.
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Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking. Sci Signal. 2017 Mar 21; 10(471). Uhm M, Bazuine M, Zhao P, Chiang SH, Xiong T, Karunanithi S, Chang L, Saltiel AR. PMID: 28325821.
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Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017 01 03; 127(1):1-4. Saltiel AR, Olefsky JM. PMID: 28045402; PMCID: PMC5199709.
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New therapeutic approaches for the treatment of obesity. Sci Transl Med. 2016 Jan 27; 8(323):323rv2. Saltiel AR. PMID: 26819198.
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Insulin Signaling in the Control of Glucose and Lipid Homeostasis. Handb Exp Pharmacol. 2016; 233:51-71. Saltiel AR. PMID: 26721672.
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p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12; 14(2):255-68. Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 26748707; PMCID: PMC4831919.
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Metabolism: Inflammation keeps old mice healthy. Nature. 2015 Dec 03; 528(7580):44-6. Maillard I, Saltiel AR. PMID: 26580010.
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A futile approach to fighting obesity? Cell. 2015 Oct 22; 163(3):539-40. Reilly SM, Saltiel AR. PMID: 26496598.
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Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans. Mol Metab. 2016 Jan; 5(1):5-18. Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel AR, Vendrell J, Fernández-Veledo S. PMID: 26844203; PMCID: PMC4703799.
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Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. J Mol Endocrinol. 2015 Oct; 55(2):81-94. Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D. PMID: 26150553; PMCID: PMC4543687.
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Gene Expression Signature in Adipose Tissue of Acromegaly Patients. PLoS One. 2015; 10(6):e0129359. Hochberg I, Tran QT, Barkan AL, Saltiel AR, Chandler WF, Bridges D. PMID: 26087292; PMCID: PMC4472931.
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White, brown, and beige; type 2 immunity gets hot. Immunity. 2015 Jan 20; 42(1):15-7. Uhm M, Saltiel AR. PMID: 25607455.
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Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem. 2015 Mar 06; 290(10):6376-86. Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR. PMID: 25596527; PMCID: PMC4358273.
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A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun. 2015 Jan 12; 6:6047. Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. PMID: 25581158; PMCID: PMC4324568.
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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb; 21(2):159-65. Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. PMID: 25559344; PMCID: PMC4320010.
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Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta. 2015 Jun; 1851(6):857-66. Bridges D, Saltiel AR. PMID: 25463477; PMCID: PMC4975561.
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A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Mol Biol Cell. 2014 Oct 01; 25(19):3059-69. Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen XW, Saltiel AR. PMID: 25103239; PMCID: PMC4230594.
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The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11a. Mol Cancer Res. 2014 Oct; 12(10):1492-508. Morrow AA, Alipour MA, Bridges D, Yao Z, Saltiel AR, Lee JM. PMID: 24962317.
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Countering inflammatory signals in obesity. Nat Immunol. 2014 May; 15(5):410-1. Reilly SM, Saltiel AR. PMID: 24747704.
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SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling. PLoS One. 2014; 9(4):e95416. Liu S, Xu R, Gerin I, Cawthorn WP, Macdougald OA, Chen XW, Saltiel AR, Koenig RJ, Xu B. PMID: 24743795; PMCID: PMC3990642.
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Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. Diabetes. 2014 Sep; 63(9):2935-48. Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR. PMID: 24722244; PMCID: PMC4141363.
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Obesity: A complex role for adipose tissue macrophages. Nat Rev Endocrinol. 2014 Apr; 10(4):193-4. Reilly SM, Saltiel AR. PMID: 24492182.
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Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell. 2014 Apr; 25(7):1171-85. Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS. PMID: 24478451; PMCID: PMC3967979.
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Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol Cell. 2014 Jan 23; 53(2):209-20. Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ. PMID: 24389102; PMCID: PMC3955741.
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Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes. 2014 Apr; 63(4):1340-52. Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD. PMID: 24379350; PMCID: PMC3964504.
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Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. Elife. 2013 Dec 24; 2:e01119. Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR. PMID: 24368730; PMCID: PMC3869376.
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Inhibition of AMPK catabolic action by GSK3. Mol Cell. 2013 May 09; 50(3):407-19. Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. PMID: 23623684; PMCID: PMC3654099.
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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med. 2013 Mar; 19(3):313-21. Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR. PMID: 23396211; PMCID: PMC3594079.
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Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem. 2013 Mar 29; 288(13):9272-83. Leto D, Uhm M, Williams A, Chen XW, Saltiel AR. PMID: 23386617; PMCID: PMC3610998.
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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17472-7. Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS. PMID: 23047693; PMCID: PMC3491506.
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TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One. 2012; 7(8):e42451. Bridges D, Chang L, Lodhi IJ, Clark NA, Saltiel AR. PMID: 22900022; PMCID: PMC3416860.
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Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell. 2012 Aug; 23(15):2955-62. Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR. PMID: 22696681; PMCID: PMC3408421.
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Insulin resistance in the defense against obesity. Cell Metab. 2012 Jun 06; 15(6):798-804. Saltiel AR. PMID: 22682220.
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Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol. 2012 May 23; 13(6):383-96. Leto D, Saltiel AR. PMID: 22617471.
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Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem. 2012 Jun 15; 287(25):20913-21. Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR. PMID: 22547071; PMCID: PMC3375515.
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p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5838-43. Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. PMID: 22460790; PMCID: PMC3326459.
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Autophagy works out. Cell Metab. 2012 Mar 07; 15(3):273-4. Klionsky DJ, Saltiel AR. PMID: 22405064; PMCID: PMC3308187.
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Phosphoinositides in insulin action and diabetes. Curr Top Microbiol Immunol. 2012; 362:61-85. Bridges D, Saltiel AR. PMID: 23086413.
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Derepressing nuclear receptors for metabolic adaptation. Cell. 2011 Nov 11; 147(4):717-8. Saltiel AR. PMID: 22078871.
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Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α. Mol Endocrinol. 2011 Dec; 25(12):2084-93. Li S, Chen XW, Yu L, Saltiel AR, Lin JD. PMID: 22052997; PMCID: PMC3231836.
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Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle. 2011 Jul 15; 10(14):2299-304. Chen XW, Saltiel AR. PMID: 21654196.
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Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011 Jun; 121(6):2111-7. Lumeng CN, Saltiel AR. PMID: 21633179; PMCID: PMC3104776.
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Exocyst function is regulated by effector phosphorylation. Nat Cell Biol. 2011 May; 13(5):580-8. Chen XW, Leto D, Xiao J, Goss J, Wang Q, Shavit JA, Xiong T, Yu G, Ginsburg D, Toomre D, Xu Z, Saltiel AR. PMID: 21516108; PMCID: PMC3904505.
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A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell. 2011 Jan 01; 22(1):141-52. Chen XW, Leto D, Xiong T, Yu G, Cheng A, Decker S, Saltiel AR. PMID: 21148297; PMCID: PMC3016972.
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Fishing out a sensor for anti-inflammatory oils. Cell. 2010 Sep 03; 142(5):672-4. Saltiel AR. PMID: 20813253.
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MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med. 2009 Dec 21; 206(13):3143-56. Westcott DJ, Delproposto JB, Geletka LM, Wang T, Singer K, Saltiel AR, Lumeng CN. PMID: 19995956; PMCID: PMC2806469.
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The protein kinase IKKepsilon regulates energy balance in obese mice. Cell. 2009 Sep 04; 138(5):961-75. Chiang SH, Bazuine M, Lumeng CN, Geletka LM, Mowers J, White NM, Ma JT, Zhou J, Qi N, Westcott D, Delproposto JB, Blackwell TS, Yull FE, Saltiel AR. PMID: 19737522; PMCID: PMC2756060.
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T-ing up inflammation in fat. Nat Med. 2009 Aug; 15(8):846-7. Lumeng CN, Maillard I, Saltiel AR. PMID: 19661987.
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Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell. 2009 Aug; 20(15):3514-24. Xiao J, Chen XW, Davies BA, Saltiel AR, Katzmann DJ, Xu Z. PMID: 19477918; PMCID: PMC2719569.
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Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions. Hum Mol Genet. 2009 Jun 01; 18(11):2045-52. Cheng A, Zhang M, Okubo M, Omichi K, Saltiel AR. PMID: 19299494; PMCID: PMC2678930.
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Von Gierke's disease adopts an orphan (and its partner). Sci Signal. 2009 Feb 17; 2(58):pe8. Cheng A, Saltiel AR. PMID: 19224896.
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The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 2008 Dec 15; 18(24):6501-4. Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA, Smith Y, Warmus JS, Tecle H. PMID: 18952427.
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Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008 Dec; 57(12):3239-46. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. PMID: 18829989; PMCID: PMC2584129.
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Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell. 2008 Jul; 19(7):2718-28. Lodhi IJ, Bridges D, Chiang SH, Zhang Y, Cheng A, Geletka LM, Weisman LS, Saltiel AR. PMID: 18434594; PMCID: PMC2441665.
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A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev. 2007 Oct 01; 21(19):2399-409. Cheng A, Zhang M, Gentry MS, Worby CA, Dixon JE, Saltiel AR. PMID: 17908927; PMCID: PMC1993871.
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Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell. 2007 Dec; 18(12):4731-40. Zhang M, Liu J, Cheng A, Deyoung SM, Saltiel AR. PMID: 17898075; PMCID: PMC2096606.
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Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell. 2007 Sep; 13(3):391-404. Chen XW, Leto D, Chiang SH, Wang Q, Saltiel AR. PMID: 17765682.
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Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr; 13(4):455-62. Lesniewski LA, Hosch SE, Neels JG, de Luca C, Pashmforoush M, Lumeng CN, Chiang SH, Scadeng M, Saltiel AR, Olefsky JM. PMID: 17351624.
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TIRFing out studies on Glut4 trafficking. Dev Cell. 2007 Jan; 12(1):4-5. Chen XW, Saltiel AR. PMID: 17199036.
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Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007 Jan; 56(1):16-23. Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. PMID: 17192460.
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Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab. 2007 Jan; 5(1):59-72. Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR. PMID: 17189207; PMCID: PMC1779820.
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Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007 Jan; 117(1):175-84. Lumeng CN, Bodzin JL, Saltiel AR. PMID: 17200717; PMCID: PMC1716210.
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CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J. 2006 Nov 15; 25(22):5284-93. Zhang M, Liu J, Cheng A, Deyoung SM, Chen X, Dold LH, Saltiel AR. PMID: 17082770; PMCID: PMC1636617.
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RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J Biol Chem. 2006 Dec 15; 281(50):38609-16. Chen XW, Inoue M, Hsu SC, Saltiel AR. PMID: 17028198.
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TC10alpha is required for insulin-stimulated glucose uptake in adipocytes. Endocrinology. 2007 Jan; 148(1):27-33. Chang L, Chiang SH, Saltiel AR. PMID: 17008399.
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GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell. 2006 Sep; 11(3):411-21. Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M. PMID: 16950130.
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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab. 2007 Jan; 292(1):E166-74. Lumeng CN, Deyoung SM, Saltiel AR. PMID: 16926380; PMCID: PMC3888778.
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Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem. 2006 Sep 22; 281(38):27982-90. Su X, Lodhi IJ, Saltiel AR, Stahl PD. PMID: 16880210.
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Insulin htts on autophagy. Autophagy. 2006 Jul-Sep; 2(3):250-3. Lumeng CN, Saltiel AR. PMID: 16874093.
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A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell. 2006 May 05; 125(3):577-91. Chun TH, Hotary KB, Sabeh F, Saltiel AR, Allen ED, Weiss SJ. PMID: 16678100.
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Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology. 2006 Jul; 147(7):3606-12. Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel AR. PMID: 16627590.
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Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov. 2006 Apr; 5(4):333-42. Lazar DF, Saltiel AR. PMID: 16582877.
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Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell. 2006 May; 17(5):2303-11. Inoue M, Chiang SH, Chang L, Chen XW, Saltiel AR. PMID: 16525015; PMCID: PMC1446102.
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More TORC for the gluconeogenic engine. Bioessays. 2006 Mar; 28(3):231-4. Cheng A, Saltiel AR. PMID: 16479585.
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TC10 and insulin-stimulated glucose transport. Methods Enzymol. 2006; 406:701-14. Chiang SH, Chang L, Saltiel AR. PMID: 16472699.
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Changes in integrin expression during adipocyte differentiation. Cell Metab. 2005 Sep; 2(3):165-77. Liu J, DeYoung SM, Zhang M, Zhang M, Cheng A, Saltiel AR. PMID: 16154099.
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Holding the line on hepatic fat. Cell Metab. 2005 Jul; 2(1):1-2. Saltiel AR. PMID: 16054091.
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The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem. 2005 Apr 22; 280(16):16125-34. Liu J, Deyoung SM, Zhang M, Dold LH, Saltiel AR. PMID: 15713660.
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Staying in SHIP shape. Nat Med. 2005 Feb; 11(2):123-4. Decker SJ, Saltiel AR. PMID: 15692594.
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Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation. 2004 Sep 14; 110(11 Suppl 1):II280-6. Voisine P, Ruel M, Khan TA, Bianchi C, Xu SH, Kohane I, Libermann TA, Otu H, Saltiel AR, Sellke FW. PMID: 15364876.
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Insulin signaling and the regulation of glucose transport. Mol Med. 2004 Jul-Dec; 10(7-12):65-71. Chang L, Chiang SH, Saltiel AR. PMID: 16307172; PMCID: PMC1431367.
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Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol. 2004 Jan 19; 164(2):279-90. Kanzaki M, Mora S, Hwang JB, Saltiel AR, Pessin JE. PMID: 14734537; PMCID: PMC2172328.
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Putting the brakes on insulin signaling. N Engl J Med. 2003 Dec 25; 349(26):2560-2. Saltiel AR. PMID: 14695419.
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Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell. 2003 Dec; 12(6):1379-89. Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR. PMID: 14690593.
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Insulin signaling in microdomains of the plasma membrane. Traffic. 2003 Nov; 4(11):711-6. Saltiel AR, Pessin JE. PMID: 14617354.
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A TUG on glucose transport. Nat Med. 2003 Nov; 9(11):1352. Saltiel AR. PMID: 14595425.
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The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem. 2003 Sep 19; 278(38):36754-62. Liu J, DeYoung SM, Hwang JB, O'Leary EE, Saltiel AR. PMID: 12842890.
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TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J. 2003 Jun 02; 22(11):2679-91. Chiang SH, Hwang J, Legendre M, Zhang M, Kimura A, Saltiel AR. PMID: 12773384; PMCID: PMC156759.
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PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest. 2003 May; 111(9):1423-32. Crosson SM, Khan A, Printen J, Pessin JE, Saltiel AR. PMID: 12727934; PMCID: PMC154451.
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Muscle or fat? Rho bridges the GAP. Cell. 2003 Apr 18; 113(2):144-5. Saltiel AR. PMID: 12705863.
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The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature. 2003 Apr 10; 422(6932):629-33. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR. PMID: 12687004.
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The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Mol Cell Biol. 2003 Feb; 23(3):961-74. Watson RT, Furukawa M, Chiang SH, Boeglin D, Kanzaki M, Saltiel AR, Pessin JE. PMID: 12529401; PMCID: PMC140699.
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Cloning and characterization of Cbl-associated protein splicing isoforms. Mol Med. 2003 Jan-Feb; 9(1-2):18-25. Zhang M, Kimura A, Saltiel AR. PMID: 12765336; PMCID: PMC1430382.
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The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12835-40. Chang L, Adams RD, Saltiel AR. PMID: 12242347; PMCID: PMC130546.
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Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Mol Biol Cell. 2002 Jul; 13(7):2334-46. Kanzaki M, Watson RT, Hou JC, Stamnes M, Saltiel AR, Pessin JE. PMID: 12134073; PMCID: PMC117317.
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APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol. 2002 Jun; 22(11):3599-609. Liu J, Kimura A, Baumann CA, Saltiel AR. PMID: 11997497; PMCID: PMC133825.
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The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem. 2002 Aug 16; 277(33):30153-8. Kimura A, Mora S, Shigematsu S, Pessin JE, Saltiel AR. PMID: 12036959.
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Insulin signaling pathways in time and space. Trends Cell Biol. 2002 Feb; 12(2):65-71. Saltiel AR, Pessin JE. PMID: 11849969.
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Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem. 2002 Apr 12; 277(15):13067-73. Chiang SH, Hou JC, Hwang J, Pessin JE, Saltiel AR. PMID: 11821390.
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Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001 Dec 13; 414(6865):799-806. Saltiel AR, Kahn CR. PMID: 11742412.
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Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol. 2001 Aug 20; 154(4):829-40. Watson RT, Shigematsu S, Chiang SH, Mora S, Kanzaki M, Macara IG, Saltiel AR, Pessin JE. PMID: 11502760; PMCID: PMC2196453.
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You are what you secrete. Nat Med. 2001 Aug; 7(8):887-8. Saltiel AR. PMID: 11479613.
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The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9098-103. Kimura A, Baumann CA, Chiang SH, Saltiel AR. PMID: 11481476; PMCID: PMC55379.
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Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1. Biochem J. 2001 May 15; 356(Pt 1):257-67. Skinner JA, Saltiel AR. PMID: 11336659; PMCID: PMC1221835.
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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature. 2001 Apr 19; 410(6831):944-8. Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR. PMID: 11309621.
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Spatial compartmentalization of signal transduction in insulin action. Bioessays. 2001 Mar; 23(3):215-22. Baumann CA, Saltiel AR. PMID: 11223878.
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New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell. 2001 Feb 23; 104(4):517-29. Saltiel AR. PMID: 11239409.
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Activation of glycogen synthase by insulin in 3T3-L1 adipocytes involves c-Cbl-associating protein (CAP)-dependent and CAP-independent signaling pathways. J Biol Chem. 2001 Mar 02; 276(9):6065-8. Baumann CA, Brady MJ, Saltiel AR. PMID: 11222622.
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The role of protein phosphatase-1 in insulin action. Recent Prog Horm Res. 2001; 56:157-73. Brady MJ, Saltiel AR. PMID: 11237211.
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Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1. Diabetes. 2000 Dec; 49(12):1967-77. Newgard CB, Brady MJ, O'Doherty RM, Saltiel AR. PMID: 11117996.
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Identification of binding sites on protein targeting to glycogen for enzymes of glycogen metabolism. J Biol Chem. 2000 Nov 10; 275(45):35034-9. Fong NM, Jensen TC, Shah AS, Parekh NN, Saltiel AR, Brady MJ. PMID: 10938087.
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PPAR gamma and the treatment of insulin resistance. Trends Endocrinol Metab. 2000 Nov; 11(9):362-8. Olefsky JM, Saltiel AR. PMID: 11042466.
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CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000 Sep 14; 407(6801):202-7. Baumann CA, Ribon V, Kanzaki M, Thurmond DC, Mora S, Shigematsu S, Bickel PE, Pessin JE, Saltiel AR. PMID: 11001060.
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Series introduction: the molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular diseases. J Clin Invest. 2000 Jul; 106(2):163-4. Saltiel AR. PMID: 10903328; PMCID: PMC314314.
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Signaling pathways in insulin action: molecular targets of insulin resistance. J Clin Invest. 2000 Jul; 106(2):165-9. Pessin JE, Saltiel AR. PMID: 10903329; PMCID: PMC314316.
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Cloning and characterization of a functional peroxisome proliferator activator receptor-gamma-responsive element in the promoter of the CAP gene. J Biol Chem. 2000 Mar 31; 275(13):9131-5. Baumann CA, Chokshi N, Saltiel AR, Ribon V. PMID: 10734046.
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Another hormone-sensitive triglyceride lipase in fat cells? Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):535-7. Saltiel AR. PMID: 10639113; PMCID: PMC33961.
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Spatial Compartmentalization in the Regulation of Glucose Metabolism by Insulin. Trends Endocrinol Metab. 1999 Dec; 10(10):408-413. Brady MJ, Pessin JE, Saltiel AR. PMID: 10542398.
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The role of glucose metabolites in the activation and translocation of glycogen synthase by insulin in 3T3-L1 adipocytes. J Biol Chem. 1999 Sep 24; 274(39):27497-504. Brady MJ, Kartha PM, Aysola AA, Saltiel AR. PMID: 10488084.
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Closing in on the cause of insulin resistance and type 2 diabetes. J Clin Invest. 1999 Sep; 104(6):675-6. Brady MJ, Saltiel AR. PMID: 10491401; PMCID: PMC408446.
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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo. Nat Med. 1999 Jul; 5(7):810-6. Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR. PMID: 10395327.
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Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell. 1999 Jul; 4(1):109-15. Syu LJ, Saltiel AR. PMID: 10445032.
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Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem. 1999 Jun 18; 274(25):17742-7. Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR. PMID: 10364216.
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Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol Cell. 1999 Jun; 3(6):751-60. Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE. PMID: 10394363.
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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. Diabetes. 1999 Feb; 48(2):403-7. Hansen L, Fjordvang H, Rasmussen SK, Vestergaard H, Echwald SM, Hansen T, Alessi D, Shenolikar S, Saltiel AR, Barbetti F, Pedersen O. PMID: 10334321.
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The functional role of CrkII in actin cytoskeleton organization and mitogenesis. J Biol Chem. 1999 Jan 29; 274(5):3001-8. Nakashima N, Rose DW, Xiao S, Egawa K, Martin SS, Haruta T, Saltiel AR, Olefsky JM. PMID: 9915838.
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Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14751-6. Ribon V, Johnson JH, Camp HS, Saltiel AR. PMID: 9843961; PMCID: PMC24521.
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The activation of glycogen synthase by insulin switches from kinase inhibition to phosphatase activation during adipogenesis in 3T3-L1 cells. J Biol Chem. 1998 Jun 05; 273(23):14063-6. Brady MJ, Bourbonais FJ, Saltiel AR. PMID: 9603900.
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Spatial determinants of specificity in insulin action. Mol Cell Biochem. 1998 May; 182(1-2):65-71. Mastick CC, Brady MJ, Printen JA, Ribon V, Saltiel AR. PMID: 9609115.
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Troglitazone increases system A amino acid transport in 3T3-L1 cells. Endocrinology. 1998 Mar; 139(3):832-7. Su TZ, Wang M, Oxender DL, Saltiel AR. PMID: 9492010.
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A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions. J Biol Chem. 1998 Feb 13; 273(7):4073-80. Ribon V, Herrera R, Kay BK, Saltiel AR. PMID: 9461600.
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Regulation of system A amino acid transport in 3T3-L1 adipocytes by insulin. J Biol Chem. 1998 Feb 06; 273(6):3173-9. Su TZ, Wang M, Syu LJ, Saltiel AR, Oxender DL. PMID: 9452428.
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A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes. Mol Cell Biol. 1998 Feb; 18(2):872-9. Ribon V, Printen JA, Hoffman NG, Kay BK, Saltiel AR. PMID: 9447983; PMCID: PMC108798.
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Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade. J Neurochem. 1998 Feb; 70(2):524-30. Desdouits-Magnen J, Desdouits F, Takeda S, Syu LJ, Saltiel AR, Buxbaum JD, Czernik AJ, Nairn AC, Greengard P. PMID: 9453546.
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Importance of MEK in neutrophil microbicidal responsiveness. J Immunol. 1998 Jan 01; 160(1):434-43. Downey GP, Butler JR, Tapper H, Fialkow L, Saltiel AR, Rubin BB, Grinstein S. PMID: 9552001.
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Inducible expression of a mutant form of MEK1 in Swiss 3T3 cells. J Cell Biochem. 1997 Dec 01; 67(3):367-77. Syu LJ, Guan KL, Saltiel AR. PMID: 9361191.
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The regulation of glycogen synthase by protein phosphatase 1 in 3T3-L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action. J Biol Chem. 1997 Nov 21; 272(47):29698-703. Brady MJ, Nairn AC, Saltiel AR. PMID: 9368038.
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Mitogen-activated protein kinase kinase inhibition decreases growth hormone stimulated transcription mediated by STAT5. Mol Cell Endocrinol. 1997 Oct 20; 133(2):169-76. Pircher TJ, Flores-Morales A, Mui AL, Saltiel AR, Norstedt G, Gustafsson JA, Haldosén LA. PMID: 9406863.
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Insulin-like growth factor-I-mediated neurite outgrowth in vitro requires mitogen-activated protein kinase activation. J Biol Chem. 1997 Aug 22; 272(34):21268-73. Kim B, Leventhal PS, Saltiel AR, Feldman EL. PMID: 9261137.
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Insulin-stimulated tyrosine phosphorylation of caveolin is specific for the differentiated adipocyte phenotype in 3T3-L1 cells. J Biol Chem. 1997 Aug 15; 272(33):20706-14. Mastick CC, Saltiel AR. PMID: 9252391.
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Role of protein targeting to glycogen (PTG) in the regulation of protein phosphatase-1 activity. J Biol Chem. 1997 Aug 08; 272(32):20198-204. Brady MJ, Printen JA, Mastick CC, Saltiel AR. PMID: 9242697.
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Proliferin induces endothelial cell chemotaxis through a G protein-coupled, mitogen-activated protein kinase-dependent pathway. Endocrinology. 1997 Jul; 138(7):2835-40. Groskopf JC, Syu LJ, Saltiel AR, Linzer DI. PMID: 9202225.
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Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem J. 1997 Jun 15; 324 ( Pt 3):839-45. Ribon V, Saltiel AR. PMID: 9210408; PMCID: PMC1218500.
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PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism. Science. 1997 Mar 07; 275(5305):1475-8. Printen JA, Brady MJ, Saltiel AR. PMID: 9045612.
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Negative modulation of membrane localization of the Raf-1 protein kinase by hyperphosphorylation. J Biol Chem. 1997 Feb 14; 272(7):3915-23. Wartmann M, Hofer P, Turowski P, Saltiel AR, Hynes NE. PMID: 9020094.
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Metabolic effects of troglitazone in the Goto-Kakizaki rat, a non-obese and normolipidemic rodent model of non-insulin-dependent diabetes mellitus. Metabolism. 1997 Feb; 46(2):192-8. O'Rourke CM, Davis JA, Saltiel AR, Cornicelli JA. PMID: 9030828.
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Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways. J Biol Chem. 1997 Jan 03; 272(1):154-61. Párrizas M, Saltiel AR, LeRoith D. PMID: 8995241.
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Design of peptidomimetic ligands for the pp60src SH2 domain. Bioorg Med Chem. 1997 Jan; 5(1):41-7. Plummer MS, Lunney EA, Para KS, Shahripour A, Stankovic CJ, Humblet C, Fergus JH, Marks JS, Herrera R, Hubbell S, Saltiel A, Sawyer TK. PMID: 9043656.
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Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes. 1996 Dec; 45(12):1661-9. Saltiel AR, Olefsky JM. PMID: 8922349.
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Phosphatidylinositol 3-kinase is necessary and sufficient for insulin-stimulated stress fiber breakdown. Endocrinology. 1996 Nov; 137(11):5045-54. Martin SS, Rose DW, Saltiel AR, Klippel A, Williams LT, Olefsky JM. PMID: 8895379.
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Targeting signal transduction in the discovery of antiproliferative drugs. Chem Biol. 1996 Nov; 3(11):887-93. Saltiel AR, Sawyer TK. PMID: 8939707.
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Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes. 1996 Oct; 45(10):1379-85. Seely BL, Staubs PA, Reichart DR, Berhanu P, Milarski KL, Saltiel AR, Kusari J, Olefsky JM. PMID: 8826975.
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Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain. Biochemistry. 1996 Sep 10; 35(36):11852-64. Thornton KH, Mueller WT, McConnell P, Zhu G, Saltiel AR, Thanabal V. PMID: 8794768.
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Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C. J Biol Chem. 1996 May 31; 271(22):12891-6. Morrison P, Saltiel AR, Rosner MR. PMID: 8662819.
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Involvement of ErbB2 in the signaling pathway leading to cell cycle progression from a truncated epidermal growth factor receptor lacking the C-terminal autophosphorylation sites. J Biol Chem. 1996 Apr 05; 271(14):8338-44. Sasaoka T, Langlois WJ, Bai F, Rose DW, Leitner JW, Decker SJ, Saltiel A, Gill GN, Kobayashi M, Draznin B, Olefsky JM. PMID: 8626530.
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Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex. J Biol Chem. 1996 Apr 05; 271(14):8300-6. Holt KH, Waters SB, Okada S, Yamauchi K, Decker SJ, Saltiel AR, Motto DG, Koretzky GA, Pessin JE. PMID: 8626525.
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Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. J Biol Chem. 1996 Mar 29; 271(13):7375-80. Ribon V, Saltiel AR. PMID: 8631760.
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Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways. J Biol Chem. 1996 Mar 01; 271(9):5033-9. Azpiazu I, Saltiel AR, DePaoli-Roach AA, Lawrence JC. PMID: 8617780.
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Diverse signaling pathways in the cellular actions of insulin. Am J Physiol. 1996 Mar; 270(3 Pt 1):E375-85. Saltiel AR. PMID: 8638681.
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Structural and functional roles of glycosylphosphoinositides. Subcell Biochem. 1996; 26:165-85. Saltiel AR. PMID: 8744265.
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The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol Cell Biol. 1996 Jan; 16(1):45-52. Ribon V, Hubbell S, Herrera R, Saltiel AR. PMID: 8524328; PMCID: PMC230977.
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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem. 1995 Nov 17; 270(46):27489-94. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PMID: 7499206.
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Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation. J Biol Chem. 1995 Oct 27; 270(43):25320-3. Langlois WJ, Sasaoka T, Saltiel AR, Olefsky JM. PMID: 7592690.
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Expression of a catalytically inert Syp blocks activation of MAP kinase pathway downstream of p21ras. Biochem Biophys Res Commun. 1995 Sep 14; 214(2):737-43. Sawada T, Milarski KL, Saltiel AR. PMID: 7677789.
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Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex. J Biol Chem. 1995 Sep 08; 270(36):20883-6. Waters SB, Holt KH, Ross SE, Syu LJ, Guan KL, Saltiel AR, Koretzky GA, Pessin JE. PMID: 7673108.
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Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem. 1995 Sep 01; 270(35):20801-7. Lazar DF, Wiese RJ, Brady MJ, Mastick CC, Waters SB, Yamauchi K, Pessin JE, Cuatrecasas P, Saltiel AR. PMID: 7657664.
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A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7686-9. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. PMID: 7644477; PMCID: PMC41210.
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Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J Biol Chem. 1995 Aug 11; 270(32):19151-7. Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM. PMID: 7642582.
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Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 04; 270(31):18531-8. Lin TA, Kong X, Saltiel AR, Blackshear PJ, Lawrence JC. PMID: 7629182.
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Identification of the major SHPTP2-binding protein that is tyrosine-phosphorylated in response to insulin. J Biol Chem. 1995 Jul 28; 270(30):17716-22. Yamauchi K, Ribon V, Saltiel AR, Pessin JE. PMID: 7629070.
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Signal transduction pathways leading to insulin-induced early gene induction. Biochemistry. 1995 Jun 27; 34(25):7996-8004. Jhun BH, Haruta T, Meinkoth JL, Leitner W, Draznin B, Saltiel AR, Pang L, Sasaoka T, Olefsky JM. PMID: 7540866.
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Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem. 1995 Jun 09; 270(23):13585-8. Pang L, Sawada T, Decker SJ, Saltiel AR. PMID: 7775407.
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Detection of a 60 kDa tyrosine-phosphorylated protein in insulin-stimulated hepatoma cells that associates with the SH2 domain of phosphatidylinositol 3-kinase. Biochem J. 1995 Jun 01; 308 ( Pt 2):579-83. Milarski KL, Lazar DF, Wiese RJ, Saltiel AR. PMID: 7539611; PMCID: PMC1136965.
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Insulin stimulates the tyrosine phosphorylation of caveolin. J Cell Biol. 1995 Jun; 129(6):1523-31. Mastick CC, Brady MJ, Saltiel AR. PMID: 7540611; PMCID: PMC2291186.
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Nerve growth factor stimulates a novel protein kinase in PC-12 cells that phosphorylates and activates mitogen-activated protein kinase kinase (MEK). Biochem J. 1995 Apr 15; 307 ( Pt 2):513-9. Pang L, Zheng CF, Guan KL, Saltiel AR. PMID: 7733891; PMCID: PMC1136678.
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Activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes. J Biol Chem. 1995 Feb 17; 270(7):3442-6. Wiese RJ, Mastick CC, Lazar DF, Saltiel AR. PMID: 7852430.
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Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. J Biol Chem. 1995 Feb 10; 270(6):2859-67. Rani CS, Abe A, Chang Y, Rosenzweig N, Saltiel AR, Radin NS, Shayman JA. PMID: 7852361.
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Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):664-8. Yamauchi K, Milarski KL, Saltiel AR, Pessin JE. PMID: 7531337; PMCID: PMC42680.
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Differentiation of peptide molecular recognition by phospholipase C gamma-1 Src homology-2 domain and a mutant Tyr phosphatase PTP1bC215S. Protein Sci. 1995 Jan; 4(1):13-20. MacLean D, Sefler AM, Zhu G, Decker SJ, Saltiel AR, Singh J, McNamara D, Dobrusin EM, Sawyer TK. PMID: 7773170; PMCID: PMC2142960.
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Identification of amino acids in the N-terminal SH2 domain of phospholipase C gamma 1 important in the interaction with epidermal growth factor receptor. Biochemistry. 1994 Dec 13; 33(49):14671-8. Gergel JR, McNamara DJ, Dobrusin EM, Zhu G, Saltiel AR, Miller WT. PMID: 7993895.
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Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem. 1994 Dec 02; 269(48):30154-7. Pandey A, Lazar DF, Saltiel AR, Dixit VM. PMID: 7982920.
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Localization of the insulin receptor binding sites for the SH2 domain proteins p85, Syp, and GAP. J Biol Chem. 1994 Nov 04; 269(44):27186-92. Staubs PA, Reichart DR, Saltiel AR, Milarski KL, Maegawa H, Berhanu P, Olefsky JM, Seely BL. PMID: 7525547.
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An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl phosphatidylinositol promotes protein dephosphorylation in rat epididymal adipocytes. Endocrinology. 1994 Nov; 135(5):1869-76. Misek DE, Saltiel AR. PMID: 7956908.
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Microinjection of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression. Mol Cell Biol. 1994 Nov; 14(11):7466-75. Jhun BH, Rose DW, Seely BL, Rameh L, Cantley L, Saltiel AR, Olefsky JM. PMID: 7935461; PMCID: PMC359282.
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Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol. Proc Natl Acad Sci U S A. 1994 Oct 11; 91(21):9665-9. Lazar DF, Knez JJ, Medof ME, Cuatrecasas P, Saltiel AR. PMID: 7524086; PMCID: PMC44877.
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The paradoxical regulation of protein phosphorylation in insulin action. FASEB J. 1994 Oct; 8(13):1034-40. Saltiel AR. PMID: 7926368.
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Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J Biol Chem. 1994 Aug 19; 269(33):21239-43. Milarski KL, Saltiel AR. PMID: 8063746.
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Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. Endocrinology. 1994 Jul; 135(1):214-22. Mastick CC, Kato H, Roberts CT, LeRoith D, Saltiel AR. PMID: 7516864.
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Cellular mechanisms of signal transduction for neurotrophins. Bioessays. 1994 Jun; 16(6):405-11. Saltiel AR, Decker SJ. PMID: 8080430.
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c-Myc does not require max for transcriptional activity in PC-12 cells. Mol Cell Neurosci. 1994 Jun; 5(3):277-82. Ribon V, Leff T, Saltiel AR. PMID: 8087425.
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Growth factor induced MEK activation is primarily mediated by an activator different from c-raf. Biochemistry. 1994 May 10; 33(18):5595-9. Zheng CF, Ohmichi M, Saltiel AR, Guan KL. PMID: 8180183.
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Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor. J Biol Chem. 1994 May 06; 269(18):13689-94. Sasaoka T, Rose DW, Jhun BH, Saltiel AR, Draznin B, Olefsky JM. PMID: 7513704.
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Sequence specificity in the recognition of the epidermal growth factor receptor by the abl Src homology 2 domain. Oncogene. 1994 May; 9(5):1379-85. Zhu G, Decker SJ, Maclean D, McNamara DJ, Singh J, Sawyer TK, Saltiel AR. PMID: 8152798.
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Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. J Biol Chem. 1994 Apr 08; 269(14):10604-8. Pang L, Milarski KL, Ohmichi M, Takata Y, Olefsky JM, Saltiel AR. PMID: 8144649.
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Developmentally regulated testicular galactolipid sulfotransferase inhibitor is a phosphoinositol glycerolipid and insulin-mimetic. Mol Reprod Dev. 1994 Apr; 37(4):462-6. Lingwood CA, Sakac D, Saltiel A. PMID: 8011331.
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Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation. J Biol Chem. 1994 Feb 04; 269(5):3783-8. Ohmichi M, Sawada T, Kanda Y, Koike K, Hirota K, Miyake A, Saltiel AR. PMID: 7508919.
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Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc Natl Acad Sci U S A. 1994 Jan 18; 91(2):797-801. Rose DW, Saltiel AR, Majumdar M, Decker SJ, Olefsky JM. PMID: 8290602; PMCID: PMC43036.
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Growth factors differentially stimulate the phosphorylation of Shc proteins and their association with Grb2 in PC-12 pheochromocytoma cells. J Biol Chem. 1994 Jan 14; 269(2):1143-8. Ohmichi M, Matuoka K, Takenawa T, Saltiel AR. PMID: 8288573.
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Nerve growth factor activates calcium-insensitive protein kinase C-epsilon in PC-12 rat pheochromocytoma cells. Biochem J. 1993 Nov 01; 295 ( Pt 3):767-72. Ohmichi M, Zhu G, Saltiel AR. PMID: 8240290; PMCID: PMC1134627.
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The stimulation of pp42mapkinase by insulin does not correlate with its metabolic actions in cells overexpressing mutant insulin receptors. Biochem Biophys Res Commun. 1993 Oct 15; 196(1):301-10. Pang L, Lazar DF, Moller DE, Flier JS, Saltiel AR. PMID: 8216304.
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Inhibition of binding of phospholipase C gamma 1 SH2 domains to phosphorylated epidermal growth factor receptor by phosphorylated peptides. Int J Pept Protein Res. 1993 Sep; 42(3):240-8. McNamara DJ, Dobrusin EM, Zhu G, Decker SJ, Saltiel AR. PMID: 8225779.
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Divergence of signaling pathways for insulin in PC-12 pheochromocytoma cells. Endocrinology. 1993 Jul; 133(1):46-56. Ohmichi M, Pang L, Ribon V, Saltiel AR. PMID: 7686484.
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Pleiotropic signaling from receptor tyrosine kinases. Curr Opin Neurobiol. 1993 Jun; 3(3):352-9. Saltiel AR, Ohmichi M. PMID: 8369628.
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The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor. Biochemistry. 1993 May 04; 32(17):4650-8. Ohmichi M, Pang L, Ribon V, Gazit A, Levitzki A, Saltiel AR. PMID: 7683492.
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Direct analysis of the binding of the abl Src homology 2 domain to the activated epidermal growth factor receptor. J Biol Chem. 1993 Jan 25; 268(3):1775-9. Zhu G, Decker SJ, Mayer BJ, Saltiel AR. PMID: 7678409.
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Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells. Biochem J. 1993 Jan 01; 289 ( Pt 1):283-7. Pang L, Decker SJ, Saltiel AR. PMID: 8380987; PMCID: PMC1132162.
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Nerve growth factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase C-gamma 1. J Biol Chem. 1992 Oct 25; 267(30):21601-6. Ohmichi M, Decker SJ, Saltiel AR. PMID: 1400471.
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Direct analysis of the binding of Src-homology 2 domains of phospholipase C to the activated epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9559-63. Zhu G, Decker SJ, Saltiel AR. PMID: 1384057; PMCID: PMC50171.
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Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. Neuron. 1992 Oct; 9(4):769-77. Ohmichi M, Decker SJ, Saltiel AR. PMID: 1382475.
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An inositol phosphate glycan derived from a Trypanosoma brucei glycosyl-phosphatidylinositol mimics some of the metabolic actions of insulin. J Biol Chem. 1992 Aug 15; 267(23):16266-73. Misek DE, Saltiel AR. PMID: 1322896.
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Nerve growth factor stimulates the activities of the raf-1 and the mitogen-activated protein kinases via the trk protooncogene. J Biol Chem. 1992 Jul 25; 267(21):14604-10. Ohmichi M, Pang L, Decker SJ, Saltiel AR. PMID: 1321811.
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Oxygen transport during anemic hypoxia in pigs: effects of digoxin on metabolism. Am J Physiol. 1992 Jul; 263(1 Pt 2):H208-17. Saltiel A, Sanfilippo DJ, Hendler R, Lister G. PMID: 1636760.
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Diversity in cellular signaling for nerve growth factor and insulin: variations on a common theme. J Invest Dermatol. 1992 Jun; 98(6 Suppl):17S-20S. Saltiel AR, Decker SJ. PMID: 1588123.
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Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase. Biochemistry. 1992 Apr 28; 31(16):4034-9. Ohmichi M, Decker SJ, Pang L, Saltiel AR. PMID: 1314657.
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Stimulation by growth hormone of MAP kinase activity in 3T3-F442A fibroblasts. J Biol Chem. 1992 Mar 25; 267(9):6074-80. Campbell GS, Pang L, Miyasaka T, Saltiel AR, Carter-Su C. PMID: 1313428.
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Diversity in cellular signaling for nerve growth factor and insulin: variations on a common theme. Mol Cell Endocrinol. 1991 Oct; 81(1-3):C197-202. Saltiel AR, Decker SJ. PMID: 1665824.
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Nerve growth factor induces the association of a 130-Kd phosphoprotein with its receptor in PC-12 pheochromocytoma cells. Cell Regul. 1991 Sep; 2(9):691-7. Ohmichi M, Decker SJ, Saltiel AR. PMID: 1660308; PMCID: PMC361863.
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Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1. Biochem Biophys Res Commun. 1991 Aug 30; 179(1):217-23. Ohmichi M, Decker SJ, Pang L, Saltiel AR. PMID: 1715690.
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Phospholipase C-gamma 1 directly associates with the p70 trk oncogene product through its src homology domains. J Biol Chem. 1991 Aug 15; 266(23):14858-61. Ohmichi M, Decker SJ, Pang L, Saltiel AR. PMID: 1831195.
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Coenzyme A-dependent, ATP-independent acylation of 2-acyl lysophosphatidylinositol in rat liver microsomes. Biochim Biophys Acta. 1991 Jul 30; 1084(3):292-9. Darnell JC, Saltiel AR. PMID: 1888777.
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Synthesis of phosphatidylinositol in rat liver microsomes is accompanied by the rapid formation of lysophosphatidylinositol. Biochim Biophys Acta. 1991 Jul 30; 1084(3):269-78. Darnell JC, Osterman DG, Saltiel AR. PMID: 1888775.
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Fatty acid remodelling of phosphatidylinositol under conditions of de novo synthesis in rat liver microsomes. Biochim Biophys Acta. 1991 Jul 30; 1084(3):279-91. Darnell JC, Osterman DG, Saltiel AR. PMID: 1888776.
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Functional consequences of lipid-mediated protein-membrane interactions. Biochem Pharmacol. 1991 Jun 21; 42(1):1-11. Saltiel AR, Ravetch J, Aderem AA. PMID: 1829888.
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Amylin increases cyclic AMP formation in L6 myocytes through calcitonin gene-related peptide receptors. Biochem Biophys Res Commun. 1991 Jun 14; 177(2):771-6. Zhu GC, Dudley DT, Saltiel AR. PMID: 1646609.
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Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells. Proc Natl Acad Sci U S A. 1991 Apr 01; 88(7):2653-7. Miyasaka T, Sternberg DW, Miyasaka J, Sherline P, Saltiel AR. PMID: 1849270; PMCID: PMC51296.
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The specific protein phosphatase inhibitor okadaic acid differentially modulates insulin action. J Cell Biochem. 1991 Apr; 45(4):374-80. Hess SL, Suchin CR, Saltiel AR. PMID: 1646209.
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Phosphatidylinositol-3 kinase is activated in v-src, v-yes, and v-fps transformed chicken embryo fibroblasts. Oncogene. 1991 Mar; 6(3):407-11. Fukui Y, Saltiel AR, Hanafusa H. PMID: 1849246.
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The role of glycosyl-phosphoinositides in hormone action. J Bioenerg Biomembr. 1991 Feb; 23(1):29-41. Saltiel AR. PMID: 1849135.
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Short-term action of insulin on Aplysia neurons: generation of a possible novel modulator of ion channels. J Neurobiol. 1991 Jan; 22(1):55-62. Shapiro E, Brown SD, Saltiel AR, Schwartz JH. PMID: 1707088.
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Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6537-41. Pfeffer LM, Strulovici B, Saltiel AR. PMID: 2168551; PMCID: PMC54571.
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Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor. J Membr Biol. 1990 Jul; 117(1):1-10. Lisanti MP, Rodriguez-Boulan E, Saltiel AR. PMID: 2144878.
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Okadaic acid stimulates the activity of microtubule associated protein kinase in PC-12 pheochromocytoma cells. Biochem Biophys Res Commun. 1990 May 16; 168(3):1237-43. Miyasaka T, Miyasaka J, Saltiel AR. PMID: 2161219.
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Signal transduction in insulin action. J Nutr Biochem. 1990 Apr; 1(4):180-8. Saltiel AR. PMID: 15539202.
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Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J Biol Chem. 1990 Mar 15; 265(8):4730-5. Miyasaka T, Chao MV, Sherline P, Saltiel AR. PMID: 2155237.
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Second messengers of insulin action. Diabetes Care. 1990 Mar; 13(3):244-56. Saltiel AR. PMID: 2137771.
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Preferred apical distribution of glycosyl-phosphatidylinositol (GPI) anchored proteins: a highly conserved feature of the polarized epithelial cell phenotype. J Membr Biol. 1990 Feb; 113(2):155-67. Lisanti MP, Le Bivic A, Saltiel AR, Rodriguez-Boulan E. PMID: 2138677; PMCID: PMC7087518.
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Second messengers of insulin action. Trends Endocrinol Metab. 1990 Jan-Feb; 1(3):158-63. Saltiel AR. PMID: 18411111.
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Short-term electrophysiological actions of insulin on Aplysia neurons: identification of a possible novel modulatory second-messenger mechanism. Cold Spring Harb Symp Quant Biol. 1990; 55:95-100. Schwartz JH, Shapiro E, Brown SD, Saltiel AR. PMID: 1983449.
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The distribution of glycosyl-phosphatidylinositol anchored proteins is differentially regulated by serum and insulin. Biochem Biophys Res Commun. 1989 Oct 31; 164(2):824-32. Lisanti MP, Darnell JC, Chan BL, Rodriguez-Boulan E, Saltiel AR. PMID: 2530980.
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Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1756-60. Chan BL, Chao MV, Saltiel AR. PMID: 2538812; PMCID: PMC286783.
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The role of glycosylphosphoinositides in signal transduction. Recent Prog Horm Res. 1989; 45:353-79; discussion 379-82. Saltiel AR, Osterman DG, Darnell JC, Chan BL, Sorbara-Cazan LR. PMID: 2682844.
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Polarized apical distribution of glycosyl-phosphatidylinositol-anchored proteins in a renal epithelial cell line. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9557-61. Lisanti MP, Sargiacomo M, Graeve L, Saltiel AR, Rodriguez-Boulan E. PMID: 2974157; PMCID: PMC282796.
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Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor. Science. 1988 Sep 23; 241(4873):1670-2. Chan BL, Lisanti MP, Rodriguez-Boulan E, Saltiel AR. PMID: 2843987.
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The function of glycosyl phosphoinositides in hormone action. Philos Trans R Soc Lond B Biol Sci. 1988 Jul 26; 320(1199):345-58. Saltiel AR, Osterman DG, Darnell JC, Sorbara-Cazan LR, Chan BL, Low MG, Cuatrecasas P. PMID: 2906143.
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In search of a second messenger for insulin. Am J Physiol. 1988 Jul; 255(1 Pt 1):C1-11. Saltiel AR, Cuatrecasas P. PMID: 2839033.
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Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science. 1988 Jan 15; 239(4837):268-75. Low MG, Saltiel AR. PMID: 3276003.
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Possible post-receptor defects in NIDDM: second messengers. Prog Clin Biol Res. 1988; 265:43-51. Saltiel AR. PMID: 3043446.
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Role of glycosyl phosphoinositides in insulin action. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:955-63. Saltiel AR, Osterman DG, Darnell JC. PMID: 2855505.
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Inositol glycan mimics the action of insulin on glucose utilization in rat adipocytes. Biochem Biophys Res Commun. 1987 Dec 31; 149(3):1084-92. Saltiel AR, Sorbara-Cazan LR. PMID: 3322285.
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Purification of a phosphatidylinositol-glycan-specific phospholipase C from liver plasma membranes: a possible target of insulin action. Proc Natl Acad Sci U S A. 1987 May; 84(9):2663-7. Fox JA, Soliz NM, Saltiel AR. PMID: 3033658; PMCID: PMC304718.
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Insulin generates an enzyme modulator from hepatic plasma membranes: regulation of adenosine 3',5'-monophosphate phosphodiesterase, pyruvate dehydrogenase, and adenylate cyclase. Endocrinology. 1987 Mar; 120(3):967-72. Saltiel AR. PMID: 3026792.
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Purification of phosphatidylinositol kinase from bovine brain myelin. Biochem J. 1987 Feb 01; 241(3):759-63. Saltiel AR, Fox JA, Sherline P, Sahyoun N, Cuatrecasas P. PMID: 3036072; PMCID: PMC1147628.
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Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan. J Biol Chem. 1987 Jan 25; 262(3):1116-21. Saltiel AR, Sherline P, Fox JA. PMID: 3542998.
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Cervico-endometrial cytology and physiological aspects of the post-partum mare. J Reprod Fertil Suppl. 1987; 35:305-9. Saltiel A, Gutierrez A, de Buen-Llado N, Sosa C. PMID: 3479585.
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Insulin-stimulated hydrolysis of a novel glycolipid generates modulators of cAMP phosphodiesterase. Science. 1986 Aug 29; 233(4767):967-72. Saltiel AR, Fox JA, Sherline P, Cuatrecasas P. PMID: 3016898.
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Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid. Proc Natl Acad Sci U S A. 1986 Aug; 83(16):5793-7. Saltiel AR, Cuatrecasas P. PMID: 3016721; PMCID: PMC386381.
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Purification of putative insulin-sensitive cAMP phosphodiesterase or its catalytic domain from rat adipocytes. Diabetes. 1986 Jun; 35(6):698-704. Saltiel AR, Steigerwalt RW. PMID: 3011573.
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Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A. 1983 Oct; 80(20):6211-3. Jacobs S, Sahyoun NE, Saltiel AR, Cuatrecasas P. PMID: 6312447; PMCID: PMC394265.
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Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity. Biochem Biophys Res Commun. 1983 Feb 10; 110(3):789-95. Saltiel AR, Doble A, Jacobs S, Cuatrecasas P. PMID: 6132601.
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Thyrotropin binding to porcine thyroid plasma membranes: kinetic and thermodynamic analyses. Mol Cell Endocrinol. 1982 Nov-Dec; 28(3):299-312. Saltiel AR, Thomas CG, Nayfeh SN. PMID: 7152094.
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Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities. Proc Natl Acad Sci U S A. 1982 Jun; 79(11):3513-7. Saltiel AR, Siegel MI, Jacobs S, Cuatrecasas P. PMID: 7048309; PMCID: PMC346451.
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Dissociation kinetics of the thyrotropin-receptor complex. Characterization of a slowly dissociable component. Mol Cell Endocrinol. 1981 Nov; 24(2):219-31. Powell-Jones CH, Saltiel AR, Thomas CG, Nayfeh SN. PMID: 6271612.
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Regulation of thyroid adenylate cyclase: guanyl nucleotide modulation of thyrotropin receptor-adenylate cyclase function. Endocrinology. 1981 Nov; 109(5):1578-89. Saltiel AR, Powell-Jones CH, Thomas CG, Nayfeh SN. PMID: 6271536.
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Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase. Biochem Biophys Res Commun. 1981 Oct 15; 102(3):1041-7. Saltiel A, Jacobs S, Siegel M, Cuatrecasas P. PMID: 7030345.
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Thyrotropin receptor-adenylate cyclase function in human thyroid neoplasms. Cancer Res. 1981 Jun; 41(6):2360-5. Saltiel AR, Powel-Jones CH, Thomas CG, Nayfeh SN. PMID: 6263464.
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Apparent "negative cooperativity" kinetics in the absence of a nonlinear Scatchard plot of thyrotropin-receptor interaction in a human thyroid adenoma. Biochem Biophys Res Commun. 1980 Jul 16; 95(1):395-403. Saltiel AR, Powell-Jones CH, Thomas CG, Nayfeh SN. PMID: 6251807.
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