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Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases. Antioxidants (Basel). 2025 May 17; 14(5). Sule RO, Rivera GDT, Vaidya T, Gartrell E, Gomes AV. PMID: 40427486; PMCID: PMC12108754.
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Editorial: Physiology of human myopathies. Front Physiol. 2025; 16:1597211. Gomes AV, Pinto JR, Szczesna-Cordary D. PMID: 40260204; PMCID: PMC12010082.
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Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling. Sci Rep. 2024 08 19; 14(1):19135. Sule RO, Morisseau C, Yang J, Hammock BD, Gomes AV. PMID: 39160161; PMCID: PMC11333623.
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Guidelines on antibody use in physiology research. Am J Physiol Renal Physiol. 2024 Mar 01; 326(3):F511-F533. Brooks HL, de Castro Brás LE, Brunt KR, Sylvester MA, Parvatiyar MS, Sirish P, Bansal SS, Sule R, Eadie AL, Knepper MA, Fenton RA, Lindsey ML, DeLeon-Pennell KY, Gomes AV. PMID: 38234298; PMCID: PMC11208033.
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Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn. Int J Mol Sci. 2023 Oct 17; 24(20). Sule RO, Phinney BS, Salemi MR, Gomes AV. PMID: 37894945; PMCID: PMC10607192.
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A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice. Int J Mol Sci. 2023 Jun 28; 24(13). Cortez NE, Pathak S, Rodriguez Lanzi C, Hong BV, Crone R, Sule R, Wang F, Chen S, Gomes AV, Baar K, Mackenzie GG. PMID: 37445930; PMCID: PMC10341838.
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Western blotting (immunoblotting): history, theory, uses, protocol and problems. Biotechniques. 2023 09; 75(3):99-114. Sule R, Rivera G, Gomes AV. PMID: 36971113; PMCID: PMC12303220.
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Dominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats. Cell Death Dis. 2022 08 17; 13(8):716. Langer HT, Mossakowski AA, Sule R, Gomes A, Baar K. PMID: 35977948; PMCID: PMC9385859.
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On 'A method for the determination of amino acid sequence in peptides' by P. Edman. Arch Biochem Biophys. 2022 09 15; 726:109304. Gomes AV. PMID: 35640665; PMCID: PMC12258393.
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Strengthening US Food Policies and Programs to Promote Equity in Nutrition Security: A Policy Statement From the American Heart Association. Circulation. 2022 06 14; 145(24):e1077-e1093. Thorndike AN, Gardner CD, Kendrick KB, Seligman HK, Yaroch AL, Gomes AV, Ivy KN, Scarmo S, Cotwright CJ, Schwartz MB, American Heart Association Advocacy Coordinating Committee. PMID: 35535604.
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The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells. Dev Cell. 2022 03 14; 57(5):654-669.e9. Moorthy BT, Jiang C, Patel DM, Ban Y, O'Shea CR, Kumar A, Yuan T, Birnbaum MD, Gomes AV, Chen X, Fontanesi F, Lampidis TJ, Barrientos A, Zhang F. PMID: 35247316; PMCID: PMC8957288.
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A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity. Oxid Med Cell Longev. 2022; 2022:5563759. Sule RO, Condon L, Gomes AV. PMID: 35096268; PMCID: PMC8791758.
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Key Characteristics of Cardiovascular Toxicants. Environ Health Perspect. 2021 09; 129(9):95001. Lind L, Araujo JA, Barchowsky A, Belcher S, Berridge BR, Chiamvimonvat N, Chiu WA, Cogliano VJ, Elmore S, Farraj AK, Gomes AV, McHale CM, Meyer-Tamaki KB, Posnack NG, Vargas HM, Yang X, Zeise L, Zhou C, Smith MT. PMID: 34558968; PMCID: PMC8462506.
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Chronic Diclofenac Exposure Increases Mitochondrial Oxidative Stress, Inflammatory Mediators, and Cardiac Dysfunction. Cardiovasc Drugs Ther. 2023 02; 37(1):25-37. Thai PN, Ren L, Xu W, Overton J, Timofeyev V, Nader CE, Haddad M, Yang J, Gomes AV, Hammock BD, Chiamvimonvat N, Sirish P. PMID: 34499283; PMCID: PMC8904649.
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Editorial: Post-translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease. Front Physiol. 2021; 12:745887. Ranek MJ, Gomes AV, Su H. PMID: 34526915; PMCID: PMC8435767.
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Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. Sci Rep. 2021 03 29; 11(1):7042. Tiwari S, Yang J, Morisseau C, Durbin-Johnson B, Hammock BD, Gomes AV. PMID: 33782432; PMCID: PMC8007717.
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Western Blotting Using In-Gel Protein Labeling as a Normalization Control: Advantages of Stain-Free Technology. Methods Mol Biol. 2021; 2261:443-456. Neris RLS, Dobles AMC, Gomes AV. PMID: 33421007; PMCID: PMC12288770.
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Oral 15-Hydroxyeicosatetraenoic Acid Induces Pulmonary Hypertension in Mice by Triggering T Cell-Dependent Endothelial Cell Apoptosis. Hypertension. 2020 09; 76(3):985-996. Ruffenach G, O'Connor E, Vaillancourt M, Hong J, Cao N, Sarji S, Moazeni S, Papesh J, Grijalva V, Cunningham CM, Shu L, Chattopadhyay A, Tiwari S, Mercier O, Perros F, Umar S, Yang X, Gomes AV, Fogelman AM, Reddy ST, Eghbali M. PMID: 32713273; PMCID: PMC8008496.
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Soluble Epoxide Hydrolase Regulation of Lipid Mediators Limits Pain. Neurotherapeutics. 2020 07; 17(3):900-916. Wagner KM, Gomes A, McReynolds CB, Hammock BD. PMID: 32875445; PMCID: PMC7609775.
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MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury. Redox Biol. 2020 09; 36:101607. Carbonell T, Gomes AV. PMID: 32593128; PMCID: PMC7322687.
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Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen. Sci Rep. 2020 02 25; 10(1):3386. Tiwari S, Mishra M, Salemi MR, Phinney BS, Newens JL, Gomes AV. PMID: 32099006; PMCID: PMC7042271.
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The Antibody Society's antibody validation webinar series. MAbs. 2020 Jan-Dec; 12(1):1794421. Voskuil JLA, Bandrowski A, Begley CG, Bradbury ARM, Chalmers AD, Gomes AV, Hardcastle T, Lund-Johansen F, Plückthun A, Roncador G, Solache A, Taussig MJ, Trimmer JS, Williams C, Goodman SL. PMID: 32748696; PMCID: PMC7531563.
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Improving the sensitivity of traditional Western blotting via Streptavidin containing Poly-horseradish peroxidase (PolyHRP). Electrophoresis. 2019 07; 40(12-13):1731-1739. Mishra M, Tiwari S, Gunaseelan A, Li D, Hammock BD, Gomes AV. PMID: 31021001; PMCID: PMC7036291.
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Ponceau S waste: Ponceau S staining for total protein normalization. Anal Biochem. 2019 06 15; 575:44-53. Sander H, Wallace S, Plouse R, Tiwari S, Gomes AV. PMID: 30914243; PMCID: PMC6954006.
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Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature. Am J Physiol Heart Circ Physiol. 2019 02 01; 316(2):H421-H429. Hwang HV, Lin Y, Rebuffatti MN, Tran DT, Lee L, Gomes AV, Li CS, Knowlton AA. PMID: 30499713.
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Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. FASEB J. 2019 03; 33(3):3152-3166. Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D. PMID: 30365366; PMCID: PMC6404564.
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Spatiotemporal Multi-Omics-Derived Atlas of Calcific Aortic Valve Disease. Circulation. 2018 07 24; 138(4):394-396. Gomes AV. PMID: 30571374; PMCID: PMC6309777.
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Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified MYL2 mice. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2338-E2347. Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. PMID: 29463717; PMCID: PMC5877945.
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Protein purification and analysis: next generation Western blotting techniques. Expert Rev Proteomics. 2017 11; 14(11):1037-1053. Mishra M, Tiwari S, Gomes AV. PMID: 28974114; PMCID: PMC6810642.
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Modulation of mitochondrial dysfunction and endoplasmic reticulum stress are key mechanisms for the wide-ranging actions of epoxy fatty acids and soluble epoxide hydrolase inhibitors. Prostaglandins Other Lipid Mediat. 2017 Nov; 133:68-78. Inceoglu B, Bettaieb A, Haj FG, Gomes AV, Hammock BD. PMID: 28847566; PMCID: PMC5824649.
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Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovasc Res. 2017 Aug 01; 113(10):1124-1136. Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. PMID: 28371863; PMCID: PMC5852631.
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Proteasome dysfunction in cardiomyopathies. J Physiol. 2017 06 15; 595(12):4051-4071. Gilda JE, Gomes AV. PMID: 28181243; PMCID: PMC5471412.
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Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res. 2017 05 30; 326:69-76. Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. PMID: 28259677; PMCID: PMC5409858.
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Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. Front Physiol. 2016; 7:520. Nguyen S, Siu R, Dewey S, Cui Z, Gomes AV. PMID: 27895589; PMCID: PMC5108889.
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Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. Oxid Med Cell Longev. 2016; 2016:9324692. Carbonell T, Alva N, Sanchez-Nuño S, Dewey S, Gomes AV. PMID: 27800122; PMCID: PMC5075307.
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Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts. Int J Cardiol. 2016 Nov 15; 223:923-935. Ghosh R, Goswami SK, Feitoza LFBB, Hammock B, Gomes AV. PMID: 27589040; PMCID: PMC5076377.
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Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016 05; 94:131-144. Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. PMID: 27049794.
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Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations. Mol Cell Proteomics. 2016 06; 15(6):1962-81. Gilda JE, Lai X, Witzmann FA, Gomes AV. PMID: 27022107; PMCID: PMC5083082.
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The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys. 2016 07 01; 601:88-96. Gilda JE, Xu Q, Martinez ME, Nguyen ST, Chase PB, Gomes AV. PMID: 26919894; PMCID: PMC4899223.
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Antibodies: Half of samples fail protein-blot tests. Nature. 2016 Jan 07; 529(7584):25. Landry M, Gomes AV. PMID: 26738583.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol. 2016 Jan 15; 594(2):453-68. West DW, Baehr LM, Marcotte GR, Chason CM, Tolento L, Gomes AV, Bodine SC, Baar K. PMID: 26548696; PMCID: PMC4713726.
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Proteomic analysis of physiological versus pathological cardiac remodeling in animal models expressing mutations in myosin essential light chains. J Muscle Res Cell Motil. 2015 Dec; 36(6):447-61. Gomes AV, Kazmierczak K, Cheah JX, Gilda JE, Yuan CC, Zhou Z, Szczesna-Cordary D. PMID: 26668058; PMCID: PMC4847725.
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Redox Signaling and the Cardiovascular and Skeletal Muscle System. Oxid Med Cell Longev. 2015; 2015:849095. Gomes AV, Rajasekaran NS, Pi X. PMID: 26523200; PMCID: PMC4617440.
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NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species. Oxid Med Cell Longev. 2015; 2015:536962. Ghosh R, Alajbegovic A, Gomes AV. PMID: 26457127; PMCID: PMC4592725.
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Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLoS One. 2015; 10(8):e0135392. Gilda JE, Ghosh R, Cheah JX, West TM, Bodine SC, Gomes AV. PMID: 26287535; PMCID: PMC4545415.
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Dynamic regulation of the proteasome by systolic overload. J Mol Cell Cardiol. 2015 Oct; 87:1-3. Carbonell T, Gomes AV. PMID: 26219953.
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Transformative Impact of Proteomics on Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 01; 132(9):852-72. Lindsey ML, Mayr M, Gomes AV, Delles C, Arrell DK, Murphy AM, Lange RA, Costello CE, Jin YF, Laskowitz DT, Sam F, Terzic A, Van Eyk J, Srinivas PR, American Heart Association Council on Functional Genomics and Translational Biology, Council on Card. PMID: 26195497.
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β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model. J Mol Cell Cardiol. 2015 Apr; 81:162-75. Negroni JA, Morotti S, Lascano EC, Gomes AV, Grandi E, Puglisi JL, Bers DM. PMID: 25724724; PMCID: PMC4380575.
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Western blotting using in-gel protein labeling as a normalization control: stain-free technology. Methods Mol Biol. 2015; 1295:381-91. Gilda JE, Gomes AV. PMID: 25820735.
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The necessity of and strategies for improving confidence in the accuracy of western blots. Expert Rev Proteomics. 2014 Oct; 11(5):549-60. Ghosh R, Gilda JE, Gomes AV. PMID: 25059473; PMCID: PMC4791038.
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Regulation of ubiquitin-proteasome and autophagy pathways after acute LPS and epoxomicin administration in mice. BMC Musculoskelet Disord. 2014 May 22; 15:166. Jamart C, Gomes AV, Dewey S, Deldicque L, Raymackers JM, Francaux M. PMID: 24885455; PMCID: PMC4041039.
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Novel sorafenib-based structural analogues: in-vitro anticancer evaluation of t-MTUCB and t-AUCMB. Anticancer Drugs. 2014 Apr; 25(4):433-46. Wecksler AT, Hwang SH, Wettersten HI, Gilda JE, Patton A, Leon LJ, Carraway KL, Gomes AV, Baar K, Weiss RH, Hammock BD. PMID: 24525589; PMCID: PMC3947856.
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Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells. Free Radic Biol Med. 2014 Jun; 71:402-414. Narasimhan M, Hong J, Atieno N, Muthusamy VR, Davidson CJ, Abu-Rmaileh N, Richardson RS, Gomes AV, Hoidal JR, Rajasekaran NS. PMID: 24613379; PMCID: PMC4493911.
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Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys. 2014 Jun 15; 552-553:50-9. Puglisi JL, Goldspink PH, Gomes AV, Utter MS, Bers DM, Solaro RJ. PMID: 24480308; PMCID: PMC4043955.
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Genetics of proteasome diseases. Scientifica (Cairo). 2013; 2013:637629. Gomes AV. PMID: 24490108; PMCID: PMC3892944.
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Identification of the immunoproteasome as a novel regulator of skeletal muscle differentiation. Mol Cell Biol. 2014 Jan; 34(1):96-109. Cui Z, Hwang SM, Gomes AV. PMID: 24164898; PMCID: PMC3911280.
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Regulation of cardiac proteasomes by ubiquitination, SUMOylation, and beyond. J Mol Cell Cardiol. 2014 Jun; 71:32-42. Cui Z, Scruggs SB, Gilda JE, Ping P, Gomes AV. PMID: 24140722; PMCID: PMC3990655.
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Crude and purified proteasome activity assays are affected by type of microplate. Anal Biochem. 2014 Feb 01; 446:44-52. Cui Z, Gilda JE, Gomes AV. PMID: 24141075; PMCID: PMC3901411.
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Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice. Hum Mol Genet. 2014 Jan 01; 23(1):209-25. Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. PMID: 23975679; PMCID: PMC3916749.
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Proteomic analysis of hearts from Akita mice suggests that increases in soluble epoxide hydrolase and antioxidative programming are key changes in early stages of diabetic cardiomyopathy. J Proteome Res. 2013 Sep 06; 12(9):3920-33. Dewey S, Lai X, Witzmann FA, Sohal M, Gomes AV. PMID: 23848590.
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Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res. 2013 Oct 01; 100(1):63-73. Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. PMID: 23761402; PMCID: PMC3778956.
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Stain-Free total protein staining is a superior loading control to β-actin for Western blots. Anal Biochem. 2013 Sep 15; 440(2):186-8. Gilda JE, Gomes AV. PMID: 23747530; PMCID: PMC3809032.
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Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure. Am J Physiol Heart Circ Physiol. 2013 Aug 15; 305(4):H551-62. Rajagopalan V, Zhao M, Reddy S, Fajardo G, Wang X, Dewey S, Gomes AV, Bernstein D. PMID: 23729213; PMCID: PMC3891246.
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How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure. J Mol Cell Cardiol. 2013 Sep; 62:108-10. Gilda JE, Gomes AV. PMID: 23732927.
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The need for agriculture phenotyping: "moving from genotype to phenotype". J Proteomics. 2013 Nov 20; 93:20-39. Boggess MV, Lippolis JD, Hurkman WJ, Fagerquist CK, Briggs SP, Gomes AV, Righetti PG, Bala K. PMID: 23563084.
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Cardiomyopathies: classification, clinical characterization, and functional phenotypes. Biochem Res Int. 2012; 2012:870942. Szczesna-Cordary D, Morimoto S, Gomes AV, Moore JR. PMID: 23304510; PMCID: PMC3529434.
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Pregnancy is associated with decreased cardiac proteasome activity and oxidative stress in mice. PLoS One. 2012; 7(11):e48601. Iorga A, Dewey S, Partow-Navid R, Gomes AV, Eghbali M. PMID: 23166589; PMCID: PMC3499532.
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The functional properties of human slow skeletal troponin T isoforms in cardiac muscle regulation. J Biol Chem. 2012 Oct 26; 287(44):37362-70. Pinto JR, Gomes AV, Jones MA, Liang J, Nguyen S, Miller T, Parvatiyar MS, Potter JD. PMID: 22977240; PMCID: PMC3481333.
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Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation. FASEB J. 2012 Jul; 26(7):2986-99. Gomes AV, Waddell DS, Siu R, Stein M, Dewey S, Furlow JD, Bodine SC. PMID: 22508689; PMCID: PMC3382096.
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The use of biophysical proteomic techniques in advancing our understanding of diseases. Biophys Rev. 2012 Jun; 4(2):125-135. Xu Q, Cui Z, Venkatraman G, Gomes AV. PMID: 28510094; PMCID: PMC5418381.
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Cardioproteomics: advancing the discovery of signaling mechanisms involved in cardiovascular diseases. Am J Cardiovasc Dis. 2011; 1(3):274-92. Cui Z, Dewey S, Gomes AV. PMID: 22254205; PMCID: PMC3253522.
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Cardiac proteasome activity in muscle ring finger-1 null mice at rest and following synthetic glucocorticoid treatment. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E967-77. Hwee DT, Gomes AV, Bodine SC. PMID: 21828340; PMCID: PMC3214003.
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Static and dynamic properties of the HCM myocardium. J Mol Cell Cardiol. 2010 Nov; 49(5):715-8. Dewey S, Xu Q, Gomes A. PMID: 20705073; PMCID: PMC2949537.
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Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res. 2010 Jun 25; 106(12):1829-38. Divald A, Kivity S, Wang P, Hochhauser E, Roberts B, Teichberg S, Gomes AV, Powell SR. PMID: 20431057.
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Non-antigen processing immunoproteasomes in diabetic hearts? J Mol Cell Cardiol. 2010 Jul; 49(1):1-4. Dewey S, Gomes AV. PMID: 20382154.
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Malignant and benign mutations in familial cardiomyopathies: insights into mutations linked to complex cardiovascular phenotypes. J Mol Cell Cardiol. 2010 May; 48(5):899-909. Xu Q, Dewey S, Nguyen S, Gomes AV. PMID: 20298698.
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Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 2010 Mar 09; 49(9):1975-84. Tikunova SB, Liu B, Swindle N, Little SC, Gomes AV, Swartz DR, Davis JP. PMID: 20128626; PMCID: PMC2845643.
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Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function? J Mol Cell Cardiol. 2010 May; 48(5):882-92. Willott RH, Gomes AV, Chang AN, Parvatiyar MS, Pinto JR, Potter JD. PMID: 19914256.
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Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques. Circ Cardiovasc Genet. 2009 Aug; 2(4):379-88. Mayr M, Grainger D, Mayr U, Leroyer AS, Leseche G, Sidibe A, Herbin O, Yin X, Gomes A, Madhu B, Griffiths JR, Xu Q, Tedgui A, Boulanger CM. PMID: 20031610.
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Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts. J Mol Cell Cardiol. 2009 Feb; 46(2):268-77. Mayr M, Liem D, Zhang J, Li X, Avliyakulov NK, Yang JI, Young G, Vondriska TM, Ladroue C, Madhu B, Griffiths JR, Gomes A, Xu Q, Ping P. PMID: 19027023; PMCID: PMC3661410.
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Contrasting proteome biology and functional heterogeneity of the 20 S proteasome complexes in mammalian tissues. Mol Cell Proteomics. 2009 Feb; 8(2):302-15. Gomes AV, Young GW, Wang Y, Zong C, Eghbali M, Drews O, Lu H, Stefani E, Ping P. PMID: 18931337; PMCID: PMC2634581.
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Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice. J Biol Chem. 2008 Jul 18; 283(29):20484-94. Wen Y, Pinto JR, Gomes AV, Xu Y, Wang Y, Wang Y, Potter JD, Kerrick WG. PMID: 18430738; PMCID: PMC2459290.
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Loss of ABCG1 results in chronic pulmonary inflammation. J Immunol. 2008 Mar 01; 180(5):3560-8. Baldán A, Gomes AV, Ping P, Edwards PA. PMID: 18292583.
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Cardiac troponin T forms a tetramer in vitro. Biochemistry. 2008 Feb 19; 47(7):1970-6. Lounes KC, Demeler B, Anderson DE, Gomes AW, Potter JD, Nassar R, Anderson PA. PMID: 18197700.
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Mammalian proteasome subpopulations with distinct molecular compositions and proteolytic activities. Mol Cell Proteomics. 2007 Nov; 6(11):2021-31. Drews O, Wildgruber R, Zong C, Sukop U, Nissum M, Weber G, Gomes AV, Ping P. PMID: 17660509.
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Protein degradation by the 26S proteasome system in the normal and stressed myocardium. Antioxid Redox Signal. 2006 Sep-Oct; 8(9-10):1677-91. Gomes AV, Zong C, Ping P. PMID: 16987021.
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Structural determinants for phosphatidic acid regulation of phospholipase C-beta1. J Biol Chem. 2006 Nov 03; 281(44):33087-94. Ross EM, Mateu D, Gomes AV, Arana C, Tran T, Litosch I. PMID: 16950781.
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Regulation of murine cardiac 20S proteasomes: role of associating partners. Circ Res. 2006 Aug 18; 99(4):372-80. Zong C, Gomes AV, Drews O, Li X, Young GW, Berhane B, Qiao X, French SW, Bardag-Gorce F, Ping P. PMID: 16857963.
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Mapping the murine cardiac 26S proteasome complexes. Circ Res. 2006 Aug 18; 99(4):362-71. Gomes AV, Zong C, Edmondson RD, Li X, Stefani E, Zhang J, Jones RC, Thyparambil S, Wang GW, Qiao X, Bardag-Gorce F, Ping P. PMID: 16857966.
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A mutation in the N-terminus of troponin I that is associated with hypertrophic cardiomyopathy affects the Ca(2+)-sensitivity, phosphorylation kinetics and proteolytic susceptibility of troponin. J Mol Cell Cardiol. 2005 Nov; 39(5):754-65. Gomes AV, Harada K, Potter JD. PMID: 16005017.
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Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development. J Biol Chem. 2005 Sep 02; 280(35):30909-15. Gomes AV, Liang J, Potter JD. PMID: 15961398.
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The murine cardiac 26S proteasome: an organelle awaiting exploration. Ann N Y Acad Sci. 2005 Jun; 1047:197-207. Gomes AV, Zong C, Edmondson RD, Berhane BT, Wang GW, Le S, Young G, Zhang J, Vondriska TM, Whitelegge JP, Jones RC, Joshua IG, Thyparambil S, Pantaleon D, Qiao J, Loo J, Ping P. PMID: 16093497.
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The miscommunicative cardiac cell: when good proteins go bad. Ann N Y Acad Sci. 2005 Jun; 1047:30-7. Gomes AV, Venkatraman G, Potter JD. PMID: 16093482.
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Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform. J Biol Chem. 2005 May 06; 280(18):17584-92. Venkatraman G, Gomes AV, Kerrick WG, Potter JD. PMID: 15623536.
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Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem. 2004 Nov 26; 279(48):49579-87. Gomes AV, Venkatraman G, Davis JP, Tikunova SB, Engel P, Solaro RJ, Potter JD. PMID: 15358779.
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Role of troponin T in disease. Mol Cell Biochem. 2004 08; 263(1-2):115-29. Gomes AV, Barnes JA, Harada K, Potter JD. PMID: 15524172.
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Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem. 2004 08; 263(1-2):99-114. Gomes AV, Potter JD. PMID: 15524171.
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Protease activated receptors in cardiovascular function and disease. Mol Cell Biochem. 2004 Aug; 263(1):227-39. Barnes JA, Singh S, Gomes AV. PMID: 27520681.
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Protease activated receptors in cardiovascular function and disease. Mol Cell Biochem. 2004 Aug; 263(1-2):227-39. Barnes JA, Singh S, Gomes AV. PMID: 15524183.
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Molecular and cellular aspects of troponin cardiomyopathies. Ann N Y Acad Sci. 2004 May; 1015:214-24. Gomes AV, Potter JD. PMID: 15201162.
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Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors. Biochemistry. 2004 Mar 16; 43(10):2732-7. Everhart D, Cartier GE, Malhotra A, Gomes AV, McIntosh JM, Luetje CW. PMID: 15005608.
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Spectroscopic characterization of the calmodulin-binding and autoinhibitory domains of calcium/calmodulin-dependent protein kinase I. Arch Biochem Biophys. 2004 Jan 15; 421(2):192-206. Yuan T, Gomes AV, Barnes JA, Hunter HN, Vogel HJ. PMID: 14984199.
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Characterization of tescalcin, a novel EF-hand protein with a single Ca2+-binding site: metal-binding properties, localization in tissues and cells, and effect on calcineurin. Biochemistry. 2003 Dec 16; 42(49):14553-65. Gutierrez-Ford C, Levay K, Gomes AV, Perera EM, Som T, Kim YM, Benovic JL, Berkovitz GD, Slepak VZ. PMID: 14661968.
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Different functional properties of troponin T mutants that cause dilated cardiomyopathy. J Biol Chem. 2003 Oct 24; 278(43):41670-6. Venkatraman G, Harada K, Gomes AV, Kerrick WG, Potter JD. PMID: 12923187.
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The role of troponins in muscle contraction. IUBMB Life. 2002 Dec; 54(6):323-33. Gomes AV, Potter JD, Szczesna-Cordary D. PMID: 12665242.
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Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart. J Biol Chem. 2002 Sep 20; 277(38):35341-9. Gomes AV, Guzman G, Zhao J, Potter JD. PMID: 12093807.
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Proteolytic signals in the primary structure of annexins. Mol Cell Biochem. 2002 Feb; 231(1-2):1-7. Barnes JA, Gomes AV. PMID: 11952151.
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Functional analysis of a troponin I (R145G) mutation associated with familial hypertrophic cardiomyopathy. J Biol Chem. 2002 Apr 05; 277(14):11670-8. Lang R, Gomes AV, Zhao J, Housmans PR, Miller T, Potter JD. PMID: 11801593.
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Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation. J Biol Chem. 2001 Mar 09; 276(10):7086-92. Szczesna D, Ghosh D, Li Q, Gomes AV, Guzman G, Arana C, Zhi G, Stull JT, Potter JD. PMID: 11102452.
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Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation. J Biol Chem. 2001 Feb 09; 276(6):3743-55. Miller T, Szczesna D, Housmans PR, Zhao J, de Freitas F, Gomes AV, Culbreath L, McCue J, Wang Y, Xu Y, Kerrick WG, Potter JD. PMID: 11060294.
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Selective degradation of annexins by chaperone-mediated autophagy. J Biol Chem. 2000 Oct 27; 275(43):33329-35. Cuervo AM, Gomes AV, Barnes JA, Dice JF. PMID: 10938088.
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Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch Biochem Biophys. 2000 Jul 01; 379(1):28-36. Gomes AV, Barnes JA, Vogel HJ. PMID: 10864438.
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Fatty acid composition and possible health effects of coconut constituents. West Indian Med J. 2000 Jun; 49(2):128-33. Pehowich DJ, Gomes AV, Barnes JA. PMID: 10948851.
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Cost- and time-efficient gel electrophoresis for mini-gel systems. Anal Biochem. 1998 Jun 15; 260(1):106-8. Gomes AV, Barnes JA. PMID: 9648661.
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Major proteins of yam bean tubers. Phytochemistry. 1997 Sep; 46(2):185-93. Gomes AV, Sirju-Charran G, Barnes JA. PMID: 9311151.
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Protein phosphatases are pest containing proteins. Biochem Mol Biol Int. 1997 Jan; 41(1):65-73. Gomes AV, Barnes JA. PMID: 9043636.
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Pest sequences in EF-hand calcium-binding proteins. Biochem Mol Biol Int. 1995 Nov; 37(5):853-60. Gomes AV, Barnes JA. PMID: 8624490.
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PEST sequences in calmodulin-binding proteins. Mol Cell Biochem. 1995 Aug-Sep; 149-150:17-27. Barnes JA, Gomes AV. PMID: 8569726.
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Calmodulin's warm embrace. Bioessays. 1994 Nov; 16(11):853. Gomes AV. PMID: 7840762.
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