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Peripheral rotavirus-specific T-cell responses following monovalent oral rotavirus vaccine in infants. NPJ Vaccines. 2026 Mar 05. Nicols AR, Lee Y, Congrave-Wilson Z, Kim M, Cheng WA, Jumarang J, Navarro J, Navarro R, Rodriguez-Angeles Y, Durand D, Taylor ZW, De León RG, Ochoa TJ, Sette A, da Silva Antunes R, Pannaraj PS. PMID: 41786777.
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The DENGVAC study: Preliminary findings on the immunogenicity of the TAK-003 dengue vaccine. J Infect. 2026 Mar; 92(3):106707. D'Abramo A, Colavita F, Ponzetta L, De Marco P, Vita S, Rosa L, Cammisa S, Tartaglia E, Scorzolini L, Lalle E, Cimini E, Notari S, Tiberi M, Grifoni A, Weiskopf D, Sette A, Petrone L, Maggi F, Goletti D, Nicastri E, DENGVAC study group. PMID: 41720307.
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Identification of immunodominant T cell epitopes in SARS-CoV-2 spike protein in Syrian hamsters. J Immunol. 2026 Feb 09; 215(2). Soudani N, Sidney J, Da Silva Antunes R, Case JB, Sharma R, Brew I, Diamond MS, Dilorenzo TP, Ellebedy AH, Sette A, Boon ACM. PMID: 41764718.
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Peptide-driven identification of TCRs reveals dynamics and phenotypes of CD4 T cells in tuberculosis. J Immunol. 2026 Feb 09; 215(2). Tippalagama R, Trevizani R, Chihab LY, Chawla A, Fung K, Greenbaum J, Kearns K, De Silva AD, Gunasinghe W, Perera J, Gunasekara H, Senevirathne DD, Scriba T, Sette A, Lindestam Arlehamn C, Burel JG, Peters B. PMID: 41241821; PMCID: PMC12718515.
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BCG immunotherapy for bladder cancer triggers systemic and local BCG-specific CD4+ Th1 responses. iScience. 2026 Feb 20; 29(2):114676. Rollin P, Pluskwa B, Artru E, Le Vaslot T, Kartasheva-Ebertz D, Biron D, Bossis M, Onodi F, LeMaoult J, Rouas-Freiss N, Chevalier MF, Lindestam Arlehamn CS, Sette A, Masson-Lecomte A, Desgrandchamps F, Xylinas E, Tonnerre P. PMID: 41660253; PMCID: PMC12877854.
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The GF-NEO discovery platform unveils a [KQE][DG] sequence motif within fusion neoantigens in pediatric cancer. iScience. 2026 Feb 20; 29(2):114512. Savoie C, Wu Z, Saab F, St-Laurent T, Thibault LN, Beauparlant CB, Déry MA, El-Hachem N, Gharsallaoui B, Tremblay SJ, Sabouret A, Chauca Torres NE, Bilodeau M, Bonneil É, Sidney J, Sette A, Droit A, Thibault P, Cellot S, Caron É, Sirois I. PMID: 41567246; PMCID: PMC12818165.
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Symptomatic SARS-CoV-2 breakthrough infections broaden the repertoire of Spike-reactive CD4 T cells. mBio. 2026 Jan 14; 17(1):e0354925. Johansson E, Lee Y, Fajardo-Rosas V, Abawi A, Logandha Ramamoorthy Premlal A, Frazier A, Greenbaum JA, Vijayanand P, da Silva Antunes R, Sette A. PMID: 41384750; PMCID: PMC12802171.
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Influenza A(H5N8) vaccine induces humoral and cell-mediated immunity against highly pathogenic avian influenza clade 2.3.4.4b A(H5N1) viruses in at-risk individuals. Nat Microbiol. 2026 Jan; 11(1):155-168. Liedes O, Reinholm A, Ekström N, Haveri A, Solastie A, Vara S, Rijnink WF, Bestebroer TM, Richard M, de Vries RD, Jalkanen P, Lindh E, Ikonen N, Grifoni A, Sette A, Laaksonen T, Holopainen R, Kakkola L, Lappalainen M, Syrjänen RK, Kolehmainen P, Julkunen I, Nohynek H, Melin M. PMID: 41350922; PMCID: PMC12768969.
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Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection. Eur J Immunol. 2025 Dec; 55(12):e70105. Song J, da Silva Antunes R, Seyede MA, Guma M, Sette A, Franco A. PMID: 41416941; PMCID: PMC12716210.
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New life into pertussis prevention. Nat Microbiol. 2025 Dec; 10(12):3045-3046. da Silva Antunes R, Sette A. PMID: 41214156.
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Impact of the bivalent COVID-19 booster on spike-specific t cell responses. Vaccine. 2026 Jan 01; 69:127995. Martínez-Pérez A, Gálvez RI, Grifoni A, Sette A, Gregersen PK, Weiskopf D. PMID: 41242291; PMCID: PMC12643170.
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Mycobacterium tuberculosis peptide-specific T cells in pulmonary granulomas display broad effector functions. iScience. 2025 Dec 19; 28(12):114034. Nelson CE, Kauffman KD, Osum KC, Sakai S, Buchanan J, Chanchu JM, Cohen M, Laux J, Dougi I, Barrows KM, Anidi IU, Lindestam Arlehamn CS, Sette A, Walker A, Shamsaddini A, Lack J, Ernst JD, Feng CG, Via LE, Fennelly KP, Carr SR, Barber DL. PMID: 41438074; PMCID: PMC12721174.
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Mpox-specific cellular and humoral immunity in mpox survivors living with HIV. Cell Rep. 2025 Nov 25; 44(11):116501. Stampfer SD, Priyamvada L, Sambyal S, Gangadhara S, Moriarty M, Satheshkumar PS, Grifoni A, Sette A, Sheth AN, Kelley CF, Amara RR. PMID: 41176764; PMCID: PMC12880552.
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Oral live attenuated polio vaccines induce enhanced T-cell responses with broad antigen recognition compared to inactivated polio vaccines. Clin Immunol. 2026 Jan; 282:110607. Snyder J, Slavik M, Harvey P, Del Rio-Guerra R, Mainou BA, Sette A, Kirkpatrick BD, Grifoni A, Crothers JW. PMID: 41077293.
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Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice. Eur J Immunol. 2025 Oct; 55(10):e70065. Basso C, De Gregorio C, Marzi R, Kirchner F, Gyülveszi G, Migaud M, Paul S, Sette A, Lanzavecchia A, LeibundGut-Landmann S, Casanova JL, Puel A, Becattini S, Sallusto F. PMID: 41054009; PMCID: PMC12501408.
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Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis. Nature. 2025 Nov; 647(8091):970-978. Michaelis T, Lindestam Arlehamn CS, Johansson E, Frazier A, Williams GP, Berry JD, Cudkowicz M, Goyal NA, Fournier C, Snyder A, Kwan JY, Crook J, Phillips EJ, Mallal SA, Ravits J, Marder KS, Sidney J, Sulzer D, Sette A. PMID: 41034581; PMCID: PMC12657233.
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Human CD4+ T cells recognize Mycobacterium tuberculosis-infected macrophages amid broader responses. J Exp Med. 2025 Dec 01; 222(12). Stetsenko V, Gail DP, Reba SM, Suzart VG, Schauner R, Sandhu AK, Sette A, Haj Dezfulian M, Lindestam Arlehamn CS, Carpenter SM. PMID: 40990918; PMCID: PMC12459340.
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Pediatric T cell and B cell responses to SARS-CoV-2 infection. JCI Insight. 2025 Oct 22; 10(20). Hills LB, Bhat N, Hurst JH, Myers A, Burke TW, McClain MT, Petzold E, Rotta AT, Turner NA, Grifoni A, Weiskopf D, Dogariu Y, Fouda GG, Permar SR, Sette A, Woods CW, Kelly MS, Crotty S. PMID: 40906527; PMCID: PMC12581660.
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T cell monocyte complexes exhibit distinct immune signatures during infection. iScience. 2025 Sep 19; 28(9):113432. Kang N, Chawla A, Hillman H, Tippalagama R, Kim C, Mikulski Z, McArdle S, Seumois G, Vijayanand P, Scriba TJ, De Silva AD, Balmaseda A, Harris E, Weiskopf D, Sette A, Arlehamn CL, Peters B, Burel JG. PMID: 40989028; PMCID: PMC12450731.
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Highly conserved Betacoronavirus sequences are broadly recognized by human T cells. Cell. 2025 Oct 02; 188(20):5653-5665.e12. Pereira Neto TA, Zmasek C, Avalos L, Sidney J, Trevizani R, Phillips E, Mallal S, Frazier A, Tan GS, Scheuermann RH, Sette A, Grifoni A. PMID: 40774254; PMCID: PMC12392877.
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Cockroach immunotherapy modulates dominant T-cell responses independent of allergen extract content. J Allergy Clin Immunol. 2025 Nov; 156(5):1303-1313. da Silva Antunes R, Sutherland A, Abawi A, Frazier A, Pomés A, Glesner J, Slater JE, Mindaye ST, Cho K, Zhou G, Ozanne MV, Calatroni A, Visness CM, Altman MC, Wood RA, O'Connor GT, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill M, Searing D, Liu AH, Zoratti E, Kattan M, Busse PJ, Sheehan W, Bacharier LB, Teach SJ, Wheatley LM, Togias A, Busse WW, Jackson DJ, Sette A. PMID: 40714043; PMCID: PMC12344379.
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Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine. iScience. 2025 Aug 15; 28(8):113167. Martínez-Balboa Y, Rodríguez-Guilarte L, Méndez C, Ríos M, Rivera DB, Moreno-Tapia D, Reyes HA, Pereira-Sánchez P, Orellana C, Cabrera A, Schultz BM, Duarte LF, Gálvez NMS, Melo-González F, Soto JA, Iturriaga C, Urzúa M, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, CoronaVac03CL Study Group, Alvarez-Figueroa MJ, González-Aramundiz JV, Domínguez MA, González PA, Abarca K, Peñaloza HF, Bueno SM, Kalergis AM. PMID: 40822332; PMCID: PMC12355589.
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Convalescent plasma therapy and long-term SARS-COV-2 antiviral immune response in a prospective cohort of patients with COVID-19. Curr Res Microb Sci. 2025; 9:100440. Barrera A, Martínez-Valdebenito C, Nervi B, Gaete-Argel A, Gálvez NMS, Osses C, Vizcaya C, Ceballos ME, Pereira J, Chang M, Rojas L, Mondaca S, Henríquez C, Kalergis AM, Sette A, Grifoni A, Soto-Rifo R, Valiente-Echeverría F, Ferres M, Balcells ME, Corre NL. PMID: 40740192; PMCID: PMC12307662.
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Identification of immunogenic and cross-reactive chikungunya virus epitopes for CD4+ T cells in chronic chikungunya disease. Nat Commun. 2025 Jul 01; 16(1):5756. Agarwal R, Ha C, Côrtes FH, Lee Y, Martínez-Pérez A, Gálvez RI, Castillo IN, Phillips EJ, Mallal SA, Balmaseda A, Harris E, Romero-Vivas CM, Premkumar L, Falconar AK, Grifoni A, Sette A, Weiskopf D. PMID: 40592820; PMCID: PMC12218217.
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Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters. Cell Rep. 2025 Jul 22; 44(7):115907. da Silva Antunes R, Fajardo-Rosas V, Yu ED, Gálvez RI, Abawi A, Escarrega EA, Martínez-Pérez A, Johansson E, Goodwin B, Frazier A, Dan JM, Crotty S, Seumois G, Weiskopf D, Vijayanand P, Sette A. PMID: 40580476; PMCID: PMC12695460.
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Loss of effector Treg signature in APOB-reactive CD4+ T cells in patients with coronary artery disease. Nat Cardiovasc Res. 2025 Jul; 4(7):841-856. Roy P, Bellapu A, Suthahar SSA, Oliaeimotlagh M, Lyu Q, Parashar S, Makings J, Wu R, Kumar S, Mehta M, Chiang AWT, Sette A, McNamara CA, Ley K. PMID: 40533521.
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T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease. NPJ Parkinsons Dis. 2025 May 26; 11(1):137. Johansson E, Freuchet A, Williams GP, Michealis T, Frazier A, Litvan I, Goldman JG, Alcalay RN, Standaert DG, Amara AW, Stover N, Fon EA, Postuma RB, Sidney J, Sulzer D, Lindestam Arlehamn CS, Sette A. PMID: 40419563; PMCID: PMC12106619.
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Mechanistic Target of Rapamycin Inhibitors and Vaccine Response in Kidney Transplant Recipients. J Am Soc Nephrol. 2025 Nov 01; 36(11):2213-2227. Perkins GB, Tunbridge MJ, Chai CS, Hope CM, Yeow AEL, Salehi T, Singer J, Shi B, Masavuli MG, Mekonnen ZA, Garcia-Valtanen P, Kireta S, Johnston JK, Drogemuller CJ, Sim BZ, Spencer SM, Sallustio BC, Comerford I, Bouras G, Weiskopf D, Sette A, Aggarwal A, Milogiannakis V, Akerman A, Turville S, Hurtado PR, Ying T, Hissaria P, Barry SC, Chadban SJ, Grubor-Bauk B, Coates PT. PMID: 40403135; PMCID: PMC12591682.
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Oral live attenuated polio vaccines induce enhanced T-cell responses with broad antigen recognition compared to inactivated polio vaccines. medRxiv. 2025 May 21. Snyder J, Slavik M, Harvey P, Del Rio-Guerra R, Mainou BA, Sette A, Kirkpatrick BD, Grifoni A, Crothers JW. PMID: 40661308; PMCID: PMC12258767.
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Chikungunya virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans. Cell Rep Med. 2025 May 20; 6(5):102134. Agarwal R, Chang J, Côrtes FH, Ha C, Villalpando J, Castillo IN, Gálvez RI, Grifoni A, Sette A, Romero-Vivas CM, Heise MT, Premkumar L, Falconar AK, Weiskopf D. PMID: 40398392; PMCID: PMC12147901.
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Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein. NPJ Parkinsons Dis. 2025 May 14; 11(1):127. Freuchet A, Johansson E, Frazier A, Litvan I, Goldman JG, Alcalay RN, Sulzer D, Lindestam Arlehamn CS, Sette A. PMID: 40368950; PMCID: PMC12078614.
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Peptide Driven Identification of TCRs (PDI-TCR) reveals dynamics and phenotypes of CD4 T cells in tuberculosis. bioRxiv. 2025 May 11. Tippalagama R, Trevizani R, Chihab LY, Chawla A, Fung K, Greenbaum J, Kearns K, De Silva AD, Gunasinghe W, Perera J, Gunasekera H, Senevirathne DD, Scriba TJ, Sette A, Arlehamn CSL, Burel JG, Peters B. PMID: 40654739; PMCID: PMC12248119.
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The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study. Lancet Microbe. 2025 Jul; 6(7):101098. Crandell J, Monteiro VS, Pischel L, Fang Z, Conde L, Zhong Y, Lawres L, de Asis GM, Maciel G, Zaleski A, Lira GS, Higa LM, Breban MI, Vogels CBF, Caria J, Pinto AR, Almeida V, Maltez F, Cordeiro R, Póvoas D, Grubaugh ND, Aoun-Barakat L, Grifoni A, Sette A, Castineiras TM, Chen S, Yildirim I, Vale AM, Omer SB, Lucas C. PMID: 40311645.
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IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination. Tuberculosis (Edinb). 2025 Jul; 153:102641. Divens AM, Ryan KJ, Sette A, Lindestam Arlehamn CS, Robinson CM. PMID: 40328205; PMCID: PMC12158641.
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Single-cell transcriptional analysis reveals allergen-specific signatures in human γδ T cells. JCI Insight. 2025 Jun 09; 10(11). Kearns K, Lewis SA, Yu ED, Abawi A, Wang E, Maiche S, Mondal M, Vijayanand P, Seumois G, Peters B, Sette A, Da Silva Antunes R. PMID: 40244697; PMCID: PMC12220975.
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Patterns and Cofactors of Polyfunctional Mycobacteria-Specific T-Cell Response Restoration Following 6-Month Antiretroviral Treatment in Children With HIV. J Infect Dis. 2025 Apr 15; 231(4):957-966. Day CL, Njuguna IN, Cranmer LM, Whatney WE, Pearson RA, Lindestam Arlehamn CS, Sette A, LaCourse SM, Escudero JN, Sasser LE, Mugo C, Okinyi HM, Maleche-Obimbo E, Wamalwa DC, John-Stewart GC. PMID: 39693245; PMCID: PMC11998549.
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β-amino acid substitution in the SIINFEKL antigen alters immunological recognition. Cancer Biol Ther. 2025 Dec; 26(1):2486141. Rastogi I, Mannone JA, Gibadullin R, Moseman JE, Sidney J, Sette A, McNeel DG, Gellman SH. PMID: 40200635; PMCID: PMC11988276.
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Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients. Cell Rep Med. 2025 Apr 15; 6(4):102050. Hu M, Oliveira APBN, Fang Z, Feng Y, Miranda M, Kowli S, Arunachalam PS, Vasudevan G, Hui HS, Grifoni A, Sette A, Litvack M, Rouphael N, Suthar MS, Ji X, Maecker HT, Hagan T, Dhillon G, Nicolls MR, Pulendran B. PMID: 40187358; PMCID: PMC12047491.
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Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop. Nat Commun. 2025 Apr 01; 16(1):3132. Willemsen L, Lee J, Shinde P, Soldevila F, Aoki M, Orfield S, Kojima M, da Silva Antunes R, Sette A, Peters B. PMID: 40169665; PMCID: PMC11961675.
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Design and development of highly conserved, HLA-promiscuous T cell multiepitope vaccines against human visceral leishmaniasis. Front Immunol. 2025; 16:1540537. Barreto AS, de Franca MNF, Dos Reis TLDS, Silva JABM, Dos Santos PL, de Oliveira FA, da Silva AM, Magalhaes LS, Secco DA, Andrade MAF, Porto LC, Rosa DS, Cavalcante RCM, Corrêa CB, Sidney J, Sette A, de Almeida RP, Palatnik-de-Sousa CB. PMID: 40230841; PMCID: PMC11994619.
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Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection. Cell Rep. 2025 Mar 25; 44(3):115366. Ansari A, Sachan S, Ahuja J, Venkadesan S, Nikam B, Kumar V, Jain S, Singh BP, Coshic P, Sikka K, Wig N, Sette A, Weiskopf D, Mohanty D, Soneja M, Gupta N. PMID: 40073863; PMCID: PMC12032839.
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Human memory CD4+ T-cells recognize Mycobacterium tuberculosis-infected macrophages amid broader pathogen-specific responses. bioRxiv. 2025 Feb 27. Stetsenko V, Gail DP, Reba S, Suzart VG, Sandhu AK, Sette A, Dezfulian MH, Arlehamn CSL, Carpenter SM. PMID: 40060660; PMCID: PMC11888249.
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Impact in the humoral and cellular immune response to SARS-CoV-2 variants after primary vaccination with AZD1222/COVISHIELD protocol in healthy adults. Vaccine. 2025 03 19; 50:126785. Capão A, Araújo MF, Tort LFL, Toledo TS, Oliveira ACA, Caetano BC, Resende PC, Martins-Filho OA, Ribeiro-Alves M, Grifoni A, Weiskopf D, Sette A, Siqueira MM, Côrtes FH, Garcia CC. PMID: 39938313.
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A Roadmap Towards the Identification and Validation of Conserved T Cell Epitope Regions in Viral Pathogen Families with Pandemic Potential. Curr Pharm Biotechnol. 2025 Jan 16. Grifoni A, Sidney J, Weiskopf D, Scheuermann RH, Sette A. PMID: 39819529; PMCID: PMC12892923.
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Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection. Front Immunol. 2024; 15:1484143. Farroni C, Altera AMG, Salmi A, Vanini V, Cuzzi G, Lindestam Arlehamn CS, Sette A, Delogu G, Palucci I, Sbarra S, Aiello A, Picchianti-Diamanti A, Gualano G, Palmieri F, Goletti D, Petruccioli E. PMID: 39872515; PMCID: PMC11770028.
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Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters. bioRxiv. 2025 Jan 09. da Silva Antunes R, Fajardo-Rosas V, Yu ED, Gálvez RI, Abawi A, Alexandar Escarrega E, Martínez-Pérez A, Johansson E, Goodwin B, Frazier A, Dan JM, Crotty S, Seumois G, Weiskopf D, Vijayanand P, Sette A. PMID: 39829792; PMCID: PMC11741356.
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The Immune Epitope Database (IEDB): 2024 update. Nucleic Acids Res. 2025 Jan 06; 53(D1):D436-D443. Vita R, Blazeska N, Marrama D, IEDB Curation Team Members , Duesing S, Bennett J, Greenbaum J, De Almeida Mendes M, Mahita J, Wheeler DK, Cantrell JR, Overton JA, Natale DA, Sette A, Peters B. PMID: 39558162; PMCID: PMC11701597.
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Using the Cancer Epitope Database and Analysis Resource (CEDAR). Methods Mol Biol. 2025; 2932:75-91. Kosaloglu-Yalçin Z, Vita R, Blazeska N, Peters B, Sette A. PMID: 40779104; PMCID: PMC12543298.
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Targets of influenza human T-cell response are mostly conserved in H5N1. mBio. 2025 Feb 05; 16(2):e0347924. Sidney J, Kim A-R, de Vries RD, Peters B, Meade PS, Krammer F, Grifoni A, Sette A. PMID: 39714185; PMCID: PMC11796400.
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Early antiviral CD4+ and CD8+ T cells are associated with upper airway clearance of SARS-CoV-2. JCI Insight. 2024 Dec 20; 9(24). Ramirez SI, Lopez PG, Faraji F, Parikh UM, Heaps A, Ritz J, Moser C, Eron JJ, Wohl D, Currier J, Daar ES, Greninger A, Klekotka P, Grifoni A, Weiskopf D, Sette A, Peters B, Hughes MD, Chew KW, Smith DM, Crotty S, Accelerating COVID-19 Therapeutic Interventions and Vaccines-2 (ACTIV-2)/A5401 Study Team. PMID: 39704169; PMCID: PMC11665554.
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PINK1 is a target of T cell responses in Parkinson's disease. J Clin Invest. 2024 Dec 17; 135(4). Williams GP, Freuchet A, Michaelis T, Frazier A, Tran NK, Rodrigues Lima-Junior J, Phillips EJ, Mallal SA, Litvan I, Goldman JG, Alcalay RN, Sidney J, Sulzer D, Sette A, Lindestam Arlehamn CS. PMID: 39688918; PMCID: PMC11827839.
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Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses. Front Immunol. 2024; 15:1412873. Bayarri-Olmos R, Sutta A, Rosbjerg A, Mortensen MM, Helgstrand C, Nielsen PF, Pérez-Alós L, González-García B, Johnsen LB, Matthiesen F, Egebjerg T, Hansen CB, Sette A, Grifoni A, da Silva Antunes R, Garred P. PMID: 39720734; PMCID: PMC11666439.
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Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults. Front Immunol. 2024; 15:1455334. Kometani K, Yorimitsu T, Jo N, Yamaguchi E, Kikuchi O, Fukahori M, Sawada T, Tsujimoto Y, Sunami A, Li M, Ito T, Pretemer Y, Gao Y, Hidaka Y, Yamamoto M, Kaku N, Nakagama Y, Kido Y, Grifoni A, Sette A, Nagao M, Morita S, Nakajima TE, Muto M, Hamazaki Y. PMID: 39717779; PMCID: PMC11663736.
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Safety and immunogenicity of an inactivated recombinant Newcastle disease virus vaccine expressing SARS-CoV-2 spike: A randomised, comparator-controlled, phase 2 trial. Vaccine. 2025 01 12; 44:126542. Thiem VD, Anh DD, Ha VH, Van Thom N, Thang TC, Mateus J, Carreño JM, Raghunandan R, Huong NM, Mercer LD, Flores J, Escarrega EA, Raskin A, Thai DH, Van Be L, Sette A, Innis BL, Krammer F, Weiskopf D. PMID: 39615342; PMCID: PMC11672239.
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Machine learning-enhanced immunopeptidomics applied to T-cell epitope discovery for COVID-19 vaccines. Nat Commun. 2024 11 28; 15(1):10316. Kovalchik KA, Hamelin DJ, Kubiniok P, Bourdin B, Mostefai F, Poujol R, Paré B, Simpson SM, Sidney J, Bonneil É, Courcelles M, Saini SK, Shahbazy M, Kapoor S, Rajesh V, Weitzen M, Grenier JC, Gharsallaoui B, Maréchal L, Wu Z, Savoie C, Sette A, Thibault P, Sirois I, Smith MA, Decaluwe H, Hussin JG, Lavallée-Adam M, Caron E. PMID: 39609459; PMCID: PMC11604954.
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PD-1 and CD73 on naive CD4+ T cells synergistically limit responses to self. Nat Immunol. 2025 Jan; 26(1):105-115. Nettersheim FS, Brunel S, Sinkovits RS, Armstrong SS, Roy P, Billitti M, Kobiyama K, Alimadadi A, Bombin S, Lu L, Zoccheddu M, Oliaeimotlagh M, Benedict CA, Sette A, Ley K. PMID: 39572641; PMCID: PMC11697576.
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A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice. Cell Host Microbe. 2024 Dec 11; 32(12):2131-2147.e8. Case JB, Sanapala S, Dillen C, Rhodes V, Zmasek C, Chicz TM, Switzer CE, Scheaffer SM, Georgiev G, Jacob-Dolan C, Hauser BM, Dos Anjos DCC, Adams LJ, Soudani N, Liang CY, Ying B, McNamara RP, Scheuermann RH, Boon ACM, Fremont DH, Whelan SPJ, Schmidt AG, Sette A, Grifoni A, Frieman MB, Diamond MS. PMID: 39561781; PMCID: PMC11637904.
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Mpox-Specific Immune Responses Elicited by Vaccination or Infection in People With HIV. J Infect Dis. 2024 Nov 15; 230(5):1110-1119. Grüner E, Grossegesse M, Stern D, Ober V, Eser TM, Reiling G, Stirner R, Ibarra G, Postel N, Conca R, Dächert C, Grifoni A, Sette A, Bogner J, Seybold U, Roider J. PMID: 38478746.
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Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues. Immunity. 2024 12 10; 57(12):2895-2913.e8. Davis-Porada J, George AB, Lam N, Caron DP, Gray JI, Huang J, Hwu J, Wells SB, Matsumoto R, Kubota M, Lee Y, Morrison-Colvin R, Jensen IJ, Ural BB, Shaabani N, Weiskopf D, Grifoni A, Sette A, Szabo PA, Teijaro JR, Sims PA, Farber DL. PMID: 39510068; PMCID: PMC11634668.
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Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop. bioRxiv. 2024 Oct 17. Willemsen L, Lee J, Shinde P, Soldevila F, Aoki M, Orfield S, Kojima M, Antunes RDS, Sette A, Peters B. PMID: 39149302; PMCID: PMC11326151.
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Autoimmunity Against Surfactant Protein B Is Associated with Pneumonitis During Checkpoint Blockade. Am J Respir Crit Care Med. 2024 Oct 01; 210(7):919-930. Wyss N, Berner F, Walter V, Jochum AK, Purde MT, Abdou MT, Sinnberg T, Hofmeister K, Pop OT, Hasan Ali O, Bauer J, Cheng HW, Lütge M, Klümper N, Diem S, Kosaloglu-Yalcin Z, Zhang Y, Sellmer L, Macek B, Karbach J, König D, Läubli H, Zender L, Meyer BS, Driessen C, Schürch CM, Jochum W, Amaral T, Heinzerling L, Cozzio A, Hegazy AN, Schneider T, Brutsche MH, Sette A, Lenz TL, Walz J, Rammensee HG, Früh M, Jäger E, Becher B, Tufman A, Nuñez N, Joerger M, Flatz L. PMID: 38626354.
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Therapy modulates the response to T cell epitopes over the spectrum of tuberculosis infection. J Infect. 2024 Dec; 89(6):106295. Petrone L, Peruzzu D, Altera AMG, Salmi A, Vanini V, Cuzzi G, Coppola A, Mellini V, Gualano G, Palmieri F, Panda S, Peters B, Sette A, Arlehamn CSL, Goletti D. PMID: 39343243.
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A novel method for characterizing cell-cell interactions at single-cell resolution reveals unique signatures in blood T cell-monocyte complexes during infection. bioRxiv. 2024 Sep 23. Kang N, Chawla A, Hillman H, Tippalagama R, Kim C, Mikulski Z, Seumois G, Vijayanand P, Scriba TJ, De Silva AD, Balmaseda A, Harris E, Weiskopf D, Sette A, Arlehamn CL, Peters B, Burel JG. PMID: 39386643; PMCID: PMC11463634.
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Inflammation and heterogeneity in synucleinopathies. Front Immunol. 2024; 15:1432342. Freuchet A, Pinçon A, Sette A, Lindestam Arlehamn CS. PMID: 39281666; PMCID: PMC11392857.
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Characterization of the Monkeypox Virus [MPX]-Specific Immune Response in MPX-Cured Individuals Using Whole Blood to Monitor Memory Response. Vaccines (Basel). 2024 Aug 26; 12(9). Petruccioli E, Sbarra S, Vita S, Salmi A, Cuzzi G, De Marco P, Matusali G, Navarra A, Pierelli L, Grifoni A, Sette A, Maggi F, Nicastri E, Goletti D. PMID: 39339995; PMCID: PMC11436000.
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Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes. J Biol Chem. 2024 09; 300(9):107702. Sharma R, Amdare NP, Ghosh A, Schloss J, Sidney J, Garforth SJ, Lopez Y, Celikgil A, Sette A, Almo SC, DiLorenzo TP. PMID: 39173948; PMCID: PMC11422593.
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Early antiviral CD4 and CD8 T cell responses and antibodies are associated with upper respiratory tract clearance of SARS-CoV-2. bioRxiv. 2024 Aug 19. Ramirez SI, Lopez PG, Faraji F, Parikh UM, Heaps A, Ritz J, Moser C, Eron JJ, Wohl DA, Currier JS, Daar ES, Greninger AL, Klekotka P, Grifoni A, Weiskopf D, Sette A, Peters B, Hughes MD, Chew KW, Smith DM, Crotty S, ACTIV-2/A5401 Study Team. PMID: 37961119; PMCID: PMC10634820.
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Booster Vaccination with BNT162b2 Improves Cellular and Humoral Immune Response in the Pediatric Population Immunized with CoronaVac. Vaccines (Basel). 2024 Aug 15; 12(8). Díaz-Dinamarca DA, Cárdenas-Cáceres S, Muena NA, Díaz P, Barra G, Puentes R, Escobar DF, Díaz-Samirin M, Santis-Alay NT, Canales C, Díaz J, García-Escorza HE, Grifoni A, Sette A, Tischler ND, Vasquez AE. PMID: 39204043; PMCID: PMC11359105.
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Adaptive immune response to bordetella pertussis during vaccination and infection: emerging perspectives and unanswered questions. Expert Rev Vaccines. 2024 Jan-Dec; 23(1):705-714. Kim AR, Sette A, da Silva Antunes R. PMID: 39037200; PMCID: PMC11306532.
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Public health management of pertussis in adults: Practical challenges and future strategies. Hum Vaccin Immunother. 2024 12 31; 20(1):2377904. MacIntyre CR, de Sousa JC, Heininger U, Kardos P, Konstantopoulos A, Middleton D, Nolan T, Papi A, Rendon A, Rizzo A, Sampson K, Sette A, Sobczyk E, Tan T, Weil-Olivier C, Weinberger B, Wilkinson T, von König CHW. PMID: 39016172; PMCID: PMC11259069.
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Identifying the strains of dengue circulating in the western province of Sri Lanka during 2019-2022. PLOS Glob Public Health. 2024; 4(7):e0003150. Abeygoonawardena H, Dassanayake K, Kariyawasam J, Chathuranga T, Sundralingam T, Gunasekara H, Wevita S, Premawansa G, Premawansa S, Wijewickrama A, Wijesinghe N, Navaratne V, Weiskopf D, Sette A, Punchihewa C, De Silva AD. PMID: 39012856; PMCID: PMC11251588.
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Next-generation IEDB tools: a platform for epitope prediction and analysis. Nucleic Acids Res. 2024 Jul 05; 52(W1):W526-W532. Yan Z, Kim K, Kim H, Ha B, Gambiez A, Bennett J, de Almeida Mendes MF, Trevizani R, Mahita J, Richardson E, Marrama D, Blazeska N, Kosaloglu-Yalçin Z, Nielsen M, Sette A, Peters B, Greenbaum JA. PMID: 38783079; PMCID: PMC11223806.
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Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination. iScience. 2024 Aug 16; 27(8):110441. Benhamouda N, Besbes A, Bauer R, Mabrouk N, Gadouas G, Desaint C, Chevrier L, Lefebvre M, Radenne A, Roelens M, Parfait B, Weiskopf D, Sette A, Gruel N, Courbebaisse M, Appay V, Paul S, Gorochov G, Ropers J, Lebbah S, Lelievre JD, Johannes L, Ulmer J, Lebeaux D, Friedlander G, De Lamballerie X, Ravel P, Kieny MP, Batteux F, Durier C, Launay O, Tartour E. PMID: 39104410; PMCID: PMC11298648.
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IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques. PLoS Pathog. 2024 Jul; 20(7):e1012339. Nelson CE, Foreman TW, Fukutani ER, Kauffman KD, Sakai S, Fleegle JD, Gomez F, NIAID/DIR Tuberculosis Imaging Program, Gould ST, Le Nouën C, Liu X, Burdette TL, Garza NL, Lafont BAP, Brooks K, Lindestam Arlehamn CS, Weiskopf D, Sette A, Hickman HD, Buchholz UJ, Johnson RF, Brenchley JM, Oberman JP, Quieroz ATL, Andrade BB, Via LE, Barber DL. PMID: 38950078; PMCID: PMC11244803.
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Profiling the SARS-CoV-2-specific T-cell response. Lancet Infect Dis. 2024 Aug; 24(8):e477-e478. Geers D, Gommers L, Tan NH, Bogers S, van Baarle D, Grifoni A, Sette A, Boerma A, Visscher F, Richard M, Funk M, Zaeck LM, van der Kuy PHM, Haagmans BL, Koopmans MP, GeurtsvanKessel CH, de Vries RD. PMID: 38909615.
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Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study. Lancet Microbe. 2024 Aug; 5(8):100859. Moraes-Cardoso I, Benet S, Carabelli J, Perez-Zsolt D, Mendoza A, Rivero A, Alemany A, Descalzo V, Alarcón-Soto Y, Grifoni A, Sette A, Moltó J, Marc A, Marks M, Mitjà O, Brander C, Paredes R, Izquierdo-Useros N, Carrillo J, Suñer C, Olvera A, Mothe B, MoViE-Immune study group. PMID: 38857615.
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T-B coculture assay for functional analysis of antigen-specific memory CD4+ T cells. STAR Protoc. 2024 06 21; 5(2):103119. Ansari A, Coshic P, Sharma A, Sette A, Weiskopf D, Gupta N. PMID: 38850540; PMCID: PMC11215106.
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SARS-CoV-2 breakthrough infections enhance T cell response magnitude, breadth, and epitope repertoire. Cell Rep Med. 2024 Jun 18; 5(6):101583. Tarke A, Ramezani-Rad P, Alves Pereira Neto T, Lee Y, Silva-Moraes V, Goodwin B, Bloom N, Siddiqui L, Avalos L, Frazier A, Zhang Z, da Silva Antunes R, Dan J, Crotty S, Grifoni A, Sette A. PMID: 38781962; PMCID: PMC11228552.
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Immune responses during COVID-19 breakthrough cases in vaccinated children and adolescents. Front Immunol. 2024; 15:1372193. Rivera-Pérez D, Méndez C, Diethelm-Varela B, Melo-González F, Vázquez Y, Meng X, Xin Q, Fasce RA, Fernández J, Mora J, Ramirez E, Acevedo ML, Valiente-Echeverría F, Soto-Rifo R, Grifoni A, Weiskopf D, Sette A, Astudillo P, Le Corre N, Abarca K, Perret C, González PA, Soto JA, Bueno SM, Kalergis AM. PMID: 38812507; PMCID: PMC11133585.
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High-resolution African HLA resource uncovers HLA-DRB1 expression effects underlying vaccine response. Nat Med. 2024 May; 30(5):1384-1394. Mentzer AJ, Dilthey AT, Pollard M, Gurdasani D, Karakoc E, Carstensen T, Muhwezi A, Cutland C, Diarra A, da Silva Antunes R, Paul S, Smits G, Wareing S, Kim H, Pomilla C, Chong AY, Brandt DYC, Nielsen R, Neaves S, Timpson N, Crinklaw A, Lindestam Arlehamn CS, Rautanen A, Kizito D, Parks T, Auckland K, Elliott KE, Mills T, Ewer K, Edwards N, Fatumo S, Webb E, Peacock S, Jeffery K, van der Klis FRM, Kaleebu P, Vijayanand P, Peters B, Sette A, Cereb N, Sirima S, Madhi SA, Elliott AM, McVean G, Hill AVS, Sandhu MS. PMID: 38740997; PMCID: PMC11108778.
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A pediatric randomized, controlled trial of German cockroach subcutaneous immunotherapy. J Allergy Clin Immunol. 2024 Sep; 154(3):735-744.e10. Zoratti E, Wood R, Pomés A, Da Silva Antunes R, Altman MC, Benson B, Wheatley LM, Cho K, Calatroni A, Little FF, Pongracic J, Makhija M, Khurana Hershey GK, Sherenian MG, Rivera-Spoljaric K, Stokes JR, Gill MA, Gruchalla RS, Chambliss J, Liu AH, Kattan M, Busse PJ, Bacharier LB, Sheehan W, Kim H, Glesner J, Gergen PJ, Togias A, Baucom JL, Visness CM, Sette A, Busse WW, Jackson DJ, Inner-City Asthma and Childhood Asthma in Urban Settings Consortia. PMID: 38718950; PMCID: PMC11380590.
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Monovalent SARS-CoV-2 mRNA Vaccine Does not Boost Omicron-Specific Immune Response in Diabetic and Control Pediatric Patients. J Infect Dis. 2024 04 12; 229(4):1059-1067. Sariol A, Vickers MA, Christensen SM, Weiskopf D, Sette A, Norris AW, Tansey MJ, Pinnaro CT, Perlman S. PMID: 37624979; PMCID: PMC11011175.
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Safety and immunogenicity of booster vaccination and fractional dosing with Ad26.COV2.S or BNT162b2 in Ad26.COV2.S-vaccinated participants. PLOS Glob Public Health. 2024; 4(4):e0002703. Riou C, Bhiman JN, Ganga Y, Sawry S, Ayres F, Baguma R, Balla SR, Benede N, Bernstein M, Besethi AS, Cele S, Crowther C, Dhar M, Geyer S, Gill K, Grifoni A, Hermanus T, Kaldine H, Keeton RS, Kgagudi P, Khan K, Lazarus E, Le Roux J, Lustig G, Madzivhandila M, Magugu SFJ, Makhado Z, Manamela NP, Mkhize Q, Mosala P, Motlou TP, Mutavhatsindi H, Mzindle NB, Nana A, Nesamari R, Ngomti A, Nkayi AA, Nkosi TP, Omondi MA, Panchia R, Patel F, Sette A, Singh U, van Graan S, Venter EM, Walters A, Moyo-Gwete T, Richardson SI, Garrett N, Rees H, Bekker LG, Gray G, Burgers WA, Sigal A, Moore PL, Fairlie L. PMID: 38603677; PMCID: PMC11008839.
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Southeast Asia initiative to combat SARS-CoV-2 variants (SEACOVARIANTS) consortium. Wellcome Open Res. 2024; 9:181. Nhu LNT, Chambers M, Chantratita N, Cheah PY, Day NPJ, Dejnirattisai W, Dunachie SJ, Grifoni A, Hamers RL, Hill J, Jones EY, Klenerman P, Mongkolsapaya J, Screaton G, Sette A, Stuart DI, Tan CW, Thwaites G, Thanh VD, Wang LF, Tan LV, SEACOVARIANTS Consortium. PMID: 39022321; PMCID: PMC11252647.
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Understanding the impact of adult pertussis and current approaches to vaccination: A narrative review and expert panel recommendations. Hum Vaccin Immunother. 2024 12 31; 20(1):2324547. Kardos P, Correia de Sousa J, Heininger U, Konstantopoulos A, MacIntyre CR, Middleton D, Nolan T, Papi A, Rendon A, Rizzo A, Sampson K, Sette A, Sobczyk E, Tan T, Weil-Olivier C, Weinberger B, Wilkinson T, Wirsing von König CH. PMID: 38564339; PMCID: PMC10989709.
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Exacerbation of CMV and Nontuberculous Mycobacterial Infections Following PD-1 Blockade for HIV-Associated Kaposi Sarcoma. Open Forum Infect Dis. 2024 May; 11(5):ofae183. Anidi IU, Sakai S, Brooks K, Fling SP, Wagner MJ, Lurain K, Lindestam Arlehamn CS, Sette A, Knox KS, Brenchley JM, Uldrick TS, Sharon E, Barber DL. PMID: 38680611; PMCID: PMC11049581.
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A multi-omics systems vaccinology resource to develop and test computational models of immunity. Cell Rep Methods. 2024 Mar 25; 4(3):100731. Shinde P, Soldevila F, Reyna J, Aoki M, Rasmussen M, Willemsen L, Kojima M, Ha B, Greenbaum JA, Overton JA, Guzman-Orozco H, Nili S, Orfield S, Gygi JP, da Silva Antunes R, Sette A, Grant B, Olsen LR, Konstorum A, Guan L, Ay F, Kleinstein SH, Peters B. PMID: 38490204; PMCID: PMC10985234.
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Investigating viral and autoimmune T cell responses associated with post-acute sequelae of COVID-19. Hum Immunol. 2024 May; 85(3):110770. Williams GP, Yu ED, Shapiro K, Wang E, Freuchet A, Frazier A, Lindestam Arlehamn CS, Sette A, da Silva Antunes R. PMID: 38433036; PMCID: PMC11144566.
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A functional identification platform reveals frequent, spontaneous neoantigen-specific T cell responses in patients with cancer. Sci Transl Med. 2024 02 28; 16(736):eabj9905. Miller AM, Kosaloglu-Yalçin Z, Westernberg L, Montero L, Bahmanof M, Frentzen A, Lanka M, Logandha Ramamoorthy Premlal A, Seumois G, Greenbaum J, Brightman SE, Soria Zavala K, Thota RR, Naradikian MS, Makani SS, Lippman SM, Sette A, Cohen EEW, Peters B, Schoenberger SP. PMID: 38416845.
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Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus. Commun Med (Lond). 2024 Feb 16; 4(1):19. Chiuppesi F, Zaia JA, Gutierrez-Franco MA, Ortega-Francisco S, Ly M, Kha M, Kim T, Dempsey S, Kar S, Grifoni A, Sette A, Wussow F, Diamond DJ. PMID: 38366141; PMCID: PMC10873322.
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Combined antiviral therapy as effective and feasible option in allogenic hematopoietic stem cell transplantation during SARS-COV-2 infection: a case report. Front Oncol. 2024; 14:1290614. Vita S, D'Abramo A, Coppola A, Farroni C, Iori AP, Faraglia F, Sette A, Grifoni A, Lindestam Arlehamn C, Bibas M, Goletti D, Nicastri E. PMID: 38414746; PMCID: PMC10896944.
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PINK1 is a target of T cell responses in Parkinson's disease. bioRxiv. 2024 Feb 12. Williams GP, Michaelis T, Lima-Junior JR, Frazier A, Tran NK, Phillips EJ, Mallal SA, Litvan I, Goldman JG, Alcalay RN, Sidney J, Sulzer D, Sette A, Lindestam Arlehamn CS. PMID: 38405939; PMCID: PMC10888789.
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Preclinical evaluation of therapeutic vaccines for chronic hepatitis B that stimulate antiviral activities of T cells and NKT cells. JHEP Rep. 2024 May; 6(5):101038. Mooney AH, Draper SL, Burn OK, Anderson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab SA, Painter GF, Hermans IF. PMID: 38694959; PMCID: PMC11061331.
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T Cell Responses in Pregnant Women Who Received mRNA-Based Vaccination to Prevent COVID-19 Revealed Unknown Exposure to the Natural Infection and Numerous SARS-CoV-2-Specific CD4- CD8- Double Negative T Cells and Regulatory T Cells. Int J Mol Sci. 2024 Feb 07; 25(4). Chambers CD, Song J, da Silva Antunes R, Sette A, Franco A. PMID: 38396707; PMCID: PMC10889590.
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Systemic and mucosal adaptive immunity to SARS-CoV-2 during the Omicron wave in patients with chronic lymphocytic leukemia. Haematologica. 2024 02 01; 109(2):646-651. Ingelman-Sundberg HM, Blixt L, Wullimann D, Wu J, Gao Y, Healy K, Muschiol S, Bogdanovic G, Åberg M, Kjellander C, Grifoni A, Sette A, Aleman S, Chen P, Blennow O, Hansson L, Ljunggren HG, Chen MS, Buggert M, Österborg A. PMID: 37646668; PMCID: PMC10828773.
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Identification of differentially recognized T cell epitopes in the spectrum of tuberculosis infection. Nat Commun. 2024 Jan 26; 15(1):765. Panda S, Morgan J, Cheng C, Saito M, Gilman RH, Ciobanu N, Crudu V, Catanzaro DG, Catanzaro A, Rodwell T, Perera JSB, Chathuranga T, Gunasena B, DeSilva AD, Peters B, Sette A, Lindestam Arlehamn CS. PMID: 38278794; PMCID: PMC10817963.
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Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant. Cell Host Microbe. 2024 Feb 14; 32(2):162-169.e3. Nesamari R, Omondi MA, Baguma R, Höft MA, Ngomti A, Nkayi AA, Besethi AS, Magugu SFJ, Mosala P, Walters A, Clark GM, Mennen M, Skelem S, Adriaanse M, Grifoni A, Sette A, Keeton RS, Ntusi NAB, Riou C, Burgers WA. PMID: 38211583; PMCID: PMC10901529.
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Memory T cells effectively recognize the SARS-CoV-2 hypermutated BA.2.86 variant. Cell Host Microbe. 2024 Feb 14; 32(2):156-161.e3. Müller TR, Gao Y, Wu J, Ribeiro O, Chen P, Bergman P, Blennow O, Hansson L, Mielke S, Nowak P, Vesterbacka J, Akber M, Söderdahl G, Smith CIE, Loré K, Chen MS, Ljungman P, Ingelman-Sundberg HM, Ljunggren HG, Österborg A, Sette A, Grifoni A, Aleman S, Buggert M. PMID: 38211584.
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PEPMatch: a tool to identify short peptide sequence matches in large sets of proteins. BMC Bioinformatics. 2023 Dec 18; 24(1):485. Marrama D, Chronister WD, Westernberg L, Vita R, Kosaloglu-Yalçin Z, Sette A, Nielsen M, Greenbaum JA, Peters B. PMID: 38110863; PMCID: PMC10726511.
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Pre-existing SARS-2-specific T cells are predicted to cross-recognize BA.2.86. Cell Host Microbe. 2024 01 10; 32(1):19-24.e2. Sette A, Sidney J, Grifoni A. PMID: 38070502; PMCID: PMC10843579.
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SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19. Sci Immunol. 2023 12 08; 8(90):eadh0687. Cai C, Gao Y, Adamo S, Rivera-Ballesteros O, Hansson L, Österborg A, Bergman P, Sandberg JK, Ljunggren HG, Björkström NK, Strålin K, Llewellyn-Lacey S, Price DA, Qin C, Grifoni A, Weiskopf D, Wherry EJ, Sette A, Aleman S, Buggert M. PMID: 38064569; PMCID: PMC7615587.
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Correction: Correlative CD4 and CD8 T-cell immunodominance in humans and mice: implications for preclinical testing. Cell Mol Immunol. 2023 Dec; 20(12):1534. Neto TAP, Sidney J, Grifoni A, Sette A. PMID: 37964123; PMCID: PMC10687077.
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Safety and immunogenicity of booster vaccination and fractional dosing with Ad26.COV2.S or BNT162b2 in Ad26.COV2.S-vaccinated participants. medRxiv. 2023 Nov 20. Riou C, Bhiman JN, Ganga Y, Sawry S, Ayres F, Baguma R, Balla SR, Benede N, Bernstein M, Besethi AS, Cele S, Crowther C, Dhar M, Geyer S, Gill K, Grifoni A, Hermanus T, Kaldine H, Keeton RS, Kgagudi P, Khan K, Lazarus E, Roux JL, Lustig G, Madzivhandila M, Magugu SF, Makhado Z, Manamela NP, Mkhize Q, Mosala P, Motlou TP, Mutavhatsindi H, Mzindle NB, Nana A, Nesamari R, Ngomti A, Nkayi AA, Nkosi TP, Omondi MA, Panchia R, Patel F, Sette A, Singh U, van Graan S, Venter EM, Walters A, Moyo-Gwete T, Richardson SI, Garrett N, Rees H, Bekker LG, Gray G, Burgers WA, Sigal A, Moore PL, Fairlie L. PMID: 38045321; PMCID: PMC10690356.
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Thioamide Analogues of MHC I Antigen Peptides. J Am Chem Soc. 2023 11 29; 145(47):25559-25569. Gibadullin R, Morris RK, Niu J, Sidney J, Sette A, Gellman SH. PMID: 37968794; PMCID: PMC10782604.
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The MegaPool Approach to Characterize Adaptive CD4+ and CD8+ T Cell Responses. Curr Protoc. 2023 Nov; 3(11):e934. da Silva Antunes R, Weiskopf D, Sidney J, Rubiro P, Peters B, Lindestam Arlehamn CS, Grifoni A, Sette A. PMID: 37966108; PMCID: PMC10662678.
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Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination. Nat Commun. 2023 10 26; 14(1):6815. Mitsi E, Diniz MO, Reiné J, Collins AM, Robinson RE, Hyder-Wright A, Farrar M, Liatsikos K, Hamilton J, Onyema O, Urban BC, Solórzano C, Belij-Rammerstorfer S, Sheehan E, Lambe T, Draper SJ, Weiskopf D, Sette A, Maini MK, Ferreira DM. PMID: 37884506; PMCID: PMC10603102.
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A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures. J Infect Dis. 2023 10 18; 228(Suppl 6):S398-S413. Kuhn RJ, Barrett ADT, Desilva AM, Harris E, Kramer LD, Montgomery RR, Pierson TC, Sette A, Diamond MS. PMID: 37849402; PMCID: PMC10582523.
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Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth. Cell. 2023 10 12; 186(21):4632-4651.e23. Wimmers F, Burrell AR, Feng Y, Zheng H, Arunachalam PS, Hu M, Spranger S, Nyhoff LE, Joshi D, Trisal M, Awasthi M, Bellusci L, Ashraf U, Kowli S, Konvinse KC, Yang E, Blanco M, Pellegrini K, Tharp G, Hagan T, Chinthrajah RS, Nguyen TT, Grifoni A, Sette A, Nadeau KC, Haslam DB, Bosinger SE, Wrammert J, Maecker HT, Utz PJ, Wang TT, Khurana S, Khatri P, Staat MA, Pulendran B. PMID: 37776858; PMCID: PMC10724861.
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Evaluation of Cross-Immunity to the Mpox Virus Due to Historic Smallpox Vaccination. Vaccines (Basel). 2023 Sep 28; 11(10). Matusali G, Petruccioli E, Cimini E, Colavita F, Bettini A, Tartaglia E, Sbarra S, Meschi S, Lapa D, Francalancia M, Bordi L, Mazzotta V, Coen S, Mizzoni K, Beccacece A, Nicastri E, Pierelli L, Antinori A, Girardi E, Vaia F, Sette A, Grifoni A, Goletti D, Puro V, Maggi F. PMID: 37896943; PMCID: PMC10610801.
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T cell exhaustion is associated with cognitive status and amyloid accumulation in Alzheimer's disease. Sci Rep. 2023 09 22; 13(1):15779. Grayson JM, Short SM, Lee CJ, Park N, Marsac C, Sette A, Lindestam Arlehamn CS, Leng XI, Lockhart SN, Craft S. PMID: 37737298; PMCID: PMC10516910.
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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection. Nat Immunol. 2023 Oct; 24(10):1711-1724. Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J, Penn Medicine BioBank, Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. PMID: 37735592.
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SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19. Autoimmunity. 2023 12; 56(1):2259133. Franco A, Song J, Chambers C, Sette A, Grifoni A. PMID: 37724524; PMCID: PMC12167603.
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Correlative CD4 and CD8 T-cell immunodominance in humans and mice: Implications for preclinical testing. Cell Mol Immunol. 2023 11; 20(11):1328-1338. Neto TAP, Sidney J, Grifoni A, Sette A. PMID: 37726420; PMCID: PMC10616275.
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A measles virus-based vaccine induces robust chikungunya virus-specific CD4+ T-cell responses in a phase II clinical trial. Vaccine. 2023 10 13; 41(43):6495-6504. Schmitz KS, Comvalius AD, Nieuwkoop NJ, Geers D, Weiskopf D, Ramsauer K, Sette A, Tschismarov R, de Vries RD, de Swart RL. PMID: 37726181.
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Stimulation of Potent Humoral and Cellular Immunity via Synthetic Dual-Antigen MVA-Based COVID-19 Vaccine COH04S1 in Cancer Patients Post Hematopoietic Cell Transplantation and Cellular Therapy. Vaccines (Basel). 2023 Sep 15; 11(9). Chiuppesi F, Ortega-Francisco S, Gutierrez MA, Li J, Ly M, Faircloth K, Mack-Onyeike J, La Rosa C, Thomas S, Zhou Q, Drake J, Slape C, Fernando P, Rida W, Kaltcheva T, Grifoni A, Sette A, Patterson A, Dempsey S, Ball B, Ali H, Salhotra A, Stein A, Nathwani N, Rosenzweig M, Nikolaenko L, Al Malki MM, Dickter J, Nanayakkara DD, Puing A, Forman SJ, Taplitz RA, Zaia JA, Nakamura R, Wussow F, Diamond DJ, Dadwal SS. PMID: 37766168; PMCID: PMC10538048.
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CD4+ T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword. Vaccines (Basel). 2023 Sep 14; 11(9). El Bissati K, Krishack PA, Zhou Y, Weber CR, Lykins J, Jankovic D, Edelblum KL, Fraczek L, Grover H, Chentoufi AA, Singh G, Reardon C, Dubey JP, Reed S, Alexander J, Sidney J, Sette A, Shastri N, McLeod R. PMID: 37766162; PMCID: PMC10535856.
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A meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps. Hum Immunol. 2023 Nov; 84(11):578-589. Foos G, Blazeska N, Nielsen M, Carter H, Kosaloglu-Yalcin Z, Peters B, Sette A. PMID: 37679223; PMCID: PMC11017785.
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Spike protein is a key target for stronger and more persistent T-cell responses-a study of mild and asymptomatic SARS-CoV-2 infection. Int J Infect Dis. 2023 Nov; 136:49-56. Ssali I, Mugaba S, Watelo AK, Bemanzi J, Katende JS, Oluka GK, Ankunda V, Baine C, Kato L, COVID-19 Immunoprofiling Team, Onyachi N, Muwanga M, Jjuuko M, Kayiwa J, Nsereko C, Auma BO, Weiskopf D, Sette A, Lutalo T, Musenero M, Kaleebu P, Serwanga J. PMID: 37683720.
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A systems vaccinology resource to develop and test computational models of immunity. bioRxiv. 2023 Aug 29. Shinde P, Soldevila F, Reyna J, Aoki M, Rasmussen M, Willemsen L, Kojima M, Ha B, Greenbaum JA, Overton JA, Guzman-Orozco H, Nili S, Orfield S, Gygi JP, da Silva Antunes R, Sette A, Grant B, Olsen LR, Konstorum A, Guan L, Ay F, Kleinstein SH, Peters B. PMID: 37693565; PMCID: PMC10491180.
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Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination. JCI Insight. 2023 08 22; 8(16). Asashima H, Kim D, Wang K, Lele N, Buitrago-Pocasangre NC, Lutz R, Cruz I, Raddassi K, Ruff WE, Racke MK, Wilson JE, Givens TS, Grifoni A, Weiskopf D, Sette A, Kleinstein SH, Montgomery RR, Shaw AC, Li F, Fan R, Hafler DA, Tomayko MM, Longbrake EE. PMID: 37606046; PMCID: PMC10543713.
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Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children. J Allergy Clin Immunol. 2023 11; 152(5):1196-1209. Lewis SA, Sutherland A, Soldevila F, Westernberg L, Aoki M, Frazier A, Maiche S, Erlewyn-Lajeunesse M, Arshad H, Leonard S, Laubach S, Dantzer JA, Wood RA, Sette A, Seumois G, Vijayanand P, Peters B. PMID: 37604312; PMCID: PMC10846667.
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Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson's disease. Neuron. 2023 11 01; 111(21):3397-3413.e5. Garretti F, Monahan C, Sloan N, Bergen J, Shahriar S, Kim SW, Sette A, Cutforth T, Kanter E, Agalliu D, Sulzer D. PMID: 37597517; PMCID: PMC11068096.
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Corrigendum: Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population. Front Immunol. 2023; 14:1274753. Martel F, Cuervo-Rojas J, Ángel J, Ariza B, González JM, Ramírez-Santana C, Acosta-Ampudia Y, Murcia-Soriano L, Montoya N, Cardozo-Romero CC, Valderrama-Beltrán SL, Cepeda M, Castellanos JC, Gómez-Restrepo C, Perdomo-Celis F, Gazquez A, Dickson A, Brien JD, Mateus J, Grifoni A, Sette A, Weiskopf D, Franco MA. PMID: 37662943; PMCID: PMC10469294.
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An update on studies characterizing adaptive immune responses in SARS-CoV-2 infection and COVID-19 vaccination. Int Immunol. 2023 08 07; 35(8):353-359. da Silva Antunes R, Grifoni A, Frazier A, Weiskopf D, Sette A. PMID: 37148294; PMCID: PMC10406159.
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Cross-reactive humoral and CD4+ T cell responses to Mu and Gamma SARS-CoV-2 variants in a Colombian population. Front Immunol. 2023; 14:1241038. Martel F, Cuervo-Rojas J, Ángel J, Ariza B, González JM, Ramírez-Santana C, Acosta-Ampudia Y, Murcia-Soriano L, Montoya N, Cardozo-Romero CC, Valderrama-Beltrán SL, Cepeda M, Castellanos JC, Gómez-Restrepo C, Perdomo-Celis F, Gazquez A, Dickson A, Brien JD, Mateus J, Grifoni A, Sette A, Weiskopf D, Franco MA. PMID: 37575243; PMCID: PMC10413264.
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T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination. Cell Host Microbe. 2023 08 09; 31(8):1404-1416.e4. da Silva Antunes R, Garrigan E, Quiambao LG, Dhanda SK, Marrama D, Westernberg L, Wang E, Abawi A, Sutherland A, Armstrong SK, Brickman TJ, Sidney J, Frazier A, Merkel TJ, Peters B, Sette A. PMID: 37490913; PMCID: PMC10528758.
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T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity. Proc Natl Acad Sci U S A. 2023 07 25; 120(30):e2306572120. Sagan SA, Moinfar Z, Moseley CE, Dandekar R, Spencer CM, Verkman AS, Ottersen OP, Sobel RA, Sidney J, Sette A, Anderson MS, Steinman L, Wilson MR, Sabatino JJ, Zamvil SS. PMID: 37463205; PMCID: PMC10372680.
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Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study. Lancet Infect Dis. 2023 11; 23(11):1302-1312. Cohn H, Bloom N, Cai GY, Clark JJ, Tarke A, Bermúdez-González MC, Altman DR, Lugo LA, Lobo FP, Marquez S, PVI study group, Chen JQ, Ren W, Qin L, Yates JL, Hunt DT, Lee WT, Crotty S, Krammer F, Grifoni A, Sette A, Simon V, Coelho CH. PMID: 37475115; PMCID: PMC10826035.
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The Importance of Measuring SARS-CoV-2-Specific T-Cell Responses in an Ongoing Pandemic. Pathogens. 2023 Jun 22; 12(7). Petrone L, Sette A, de Vries RD, Goletti D. PMID: 37513709; PMCID: PMC10385870.
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Targets and cross-reactivity of human T cell recognition of common cold coronaviruses. Cell Rep Med. 2023 06 20; 4(6):101088. Tarke A, Zhang Y, Methot N, Narowski TM, Phillips E, Mallal S, Frazier A, Filaci G, Weiskopf D, Dan JM, Premkumar L, Scheuermann RH, Sette A, Grifoni A. PMID: 37295422; PMCID: PMC10242702.
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Durability of immune responses to mRNA booster vaccination against COVID-19. J Clin Invest. 2023 05 15; 133(10). Arunachalam PS, Lai L, Samaha H, Feng Y, Hu M, Hui HS, Wali B, Ellis M, Davis-Gardner ME, Huerta C, Bechnak K, Bechnak S, Lee M, Litvack MB, Losada C, Grifoni A, Sette A, Zarnitsyna VI, Rouphael N, Suthar MS, Pulendran B. PMID: 36951954; PMCID: PMC10178835.
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Evidence for broad cross-reactivity of the SARS-CoV-2 NSP12-directed CD4+ T-cell response with pre-primed responses directed against common cold coronaviruses. Front Immunol. 2023; 14:1182504. Westphal T, Mader M, Karsten H, Cords L, Knapp M, Schulte S, Hermanussen L, Peine S, Ditt V, Grifoni A, Addo MM, Huber S, Sette A, Lütgehetmann M, Pischke S, Kwok WW, Sidney J, Schulze Zur Wiesch J. PMID: 37215095; PMCID: PMC10196118.
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Memory profiles distinguish cross-reactive and virus-specific T cell immunity to mpox. Cell Host Microbe. 2023 06 14; 31(6):928-936.e4. Adamo S, Gao Y, Sekine T, Mily A, Wu J, Storgärd E, Westergren V, Filén F, Treutiger CJ, Sandberg JK, Sällberg M, Bergman P, Llewellyn-Lacey S, Ljunggren HG, Price DA, Ekström AM, Sette A, Grifoni A, Buggert M. PMID: 37236191; PMCID: PMC10211501.
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Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults. EBioMedicine. 2023 May; 91:104563. Méndez C, Peñaloza HF, Schultz BM, Piña-Iturbe A, Ríos M, Moreno-Tapia D, Pereira-Sánchez P, Leighton D, Orellana C, Covarrubias C, Gálvez NMS, Soto JA, Duarte LF, Rivera-Pérez D, Vázquez Y, Cabrera A, Bustos S, Iturriaga C, Urzua M, Navarrete MS, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Acevedo M, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, CoronaVac03CL Study Group, González-Aramundiz JV, González PA, Abarca K, Melo-González F, Bueno SM, Kalergis AM. PMID: 37099842; PMCID: PMC10129368.
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Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection. bioRxiv. 2023 Apr 13. Panda S, Morgan J, Cheng C, Saito M, Gilman RH, Ciobanu N, Crudu V, Catanzaro DG, Catanzaro A, Rodwell T, Perera JSB, Chathuranga T, Gunasena B, DeSilva AD, Peters B, Sette A, Lindestam Arlehamn CS. PMID: 37090558; PMCID: PMC10120689.
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Metabolic dysregulation impairs lymphocyte function during severe SARS-CoV-2 infection. Commun Biol. 2023 04 07; 6(1):374. Gurshaney S, Morales-Alvarez A, Ezhakunnel K, Manalo A, Huynh TH, Abe JI, Le NT, Weiskopf D, Sette A, Lupu DS, Gardell SJ, Nguyen H. PMID: 37029220; PMCID: PMC10080180.
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IEDB-3D 2.0: Structural data analysis within the Immune Epitope Database. Protein Sci. 2023 04; 32(4):e4605. Mendes M, Mahita J, Blazeska N, Greenbaum J, Ha B, Wheeler K, Wang J, Shackelford D, Sette A, Peters B. PMID: 36806329; PMCID: PMC10022491.
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Virus-Specific Stem Cell Memory CD8+ T Cells May Indicate a Long-Term Protection against Evolving SARS-CoV-2. Diagnostics (Basel). 2023 Mar 28; 13(7). Aleksova M, Todorova Y, Emilova R, Baymakova M, Yancheva N, Andonova R, Zasheva A, Grifoni A, Weiskopf D, Sette A, Nikolova M. PMID: 37046496; PMCID: PMC10093371.
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Genome-wide characterization of T cell responses to Bordetella pertussis reveals broad reactivity and similar polarization irrespective of childhood vaccination profiles. bioRxiv. 2023 Mar 25. da Silva Antunes R, Garrigan E, Quiambao LG, Dhanda SK, Marrama D, Westernberg L, Wang E, Sutherland A, Armstrong SK, Brickman TJ, Sidney J, Frazier A, Merkel T, Peters B, Sette A. PMID: 36993748; PMCID: PMC10055406.
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Characterization of the immune impairment of patients with tuberculosis and COVID-19 coinfection. Int J Infect Dis. 2023 May; 130 Suppl 1:S34-S42. Najafi-Fard S, Aiello A, Navarra A, Cuzzi G, Vanini V, Migliori GB, Gualano G, Cerva C, Grifoni A, Sette A, Vaia F, Palmieri F, Goletti D. PMID: 36944383; PMCID: PMC10027657.
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SARS-CoV-2 Omicron (B.1.1.529) shows minimal neurotropism in a double-humanized mouse model. Antiviral Res. 2023 04; 212:105580. Alves RPDS, Wang YT, Mikulski Z, McArdle S, Shafee N, Valentine KM, Miller R, Verma SK, Batiz FAS, Maule E, Nguyen MN, Timis J, Mann C, Zandonatti M, Alarcon S, Rowe J, Kronenberg M, Weiskopf D, Sette A, Hastie K, Saphire EO, Festin S, Kim K, Shresta S. PMID: 36940916; PMCID: PMC10027296.
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Mpox vaccine and infection-driven human immune signatures. medRxiv. 2023 Mar 09. Cohn H, Bloom N, Cai G, Clark J, Tarke A, Bermúdez-González MC, Altman D, Lugo LA, Lobo FP, Marquez S, PVI study group, Chen JQ, Ren W, Qin L, Crotty S, Krammer F, Grifoni A, Sette A, Simon V, Coelho CH. PMID: 36945651; PMCID: PMC10029032.
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Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques. mBio. 2023 04 25; 14(2):e0022023. Hoft SG, Kauffman KD, Sakai S, Lindestam Arlehamn CS, Sette A, Hoft DF, Herbert R, Barber DL. PMID: 36880755; PMCID: PMC10127997.
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Impaired SARS-CoV-2 Variant Neutralization and CD8+ T-cell Responses Following 3 Doses of mRNA Vaccines in Myeloma: Correlation with Breakthrough Infections. Blood Cancer Discov. 2023 03 01; 4(2):106-117. Azeem MI, Nooka AK, Shanmugasundaram U, Cheedarla N, Potdar S, Manalo RJ, Moreno A, Switchenko JM, Cheedarla S, Doxie DB, Radzievski R, Ellis ML, Manning KE, Wali B, Valanparambil RM, Maples KT, Baymon E, Kaufman JL, Hofmeister CC, Joseph NS, Lonial S, Roback JD, Sette A, Ahmed R, Suthar MS, Neish AS, Dhodapkar MV, Dhodapkar KM. PMID: 36511813; PMCID: PMC9975771.
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses. Science. 2023 02 17; 379(6633):eabg2752. He M, Roussak K, Ma F, Borcherding N, Garin V, White M, Schutt C, Jensen TI, Zhao Y, Iberg CA, Shah K, Bhatia H, Korenfeld D, Dinkel S, Gray J, Ulezko Antonova A, Ferris S, Donermeyer D, Lindestam Arlehamn C, Gubin MM, Luo J, Gorvel L, Pellegrini M, Sette A, Tung T, Bak R, Modlin RL, Fields RC, Schreiber RD, Allen PM, Klechevsky E. PMID: 36795805; PMCID: PMC10424698.
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Antigen Discovery for Next-Generation Pertussis Vaccines Using Immunoproteomics and Transposon-Directed Insertion Sequencing. J Infect Dis. 2023 02 14; 227(4):583-591. Gregg KA, Wang Y, Warfel J, Schoenfeld E, Jankowska E, Cipollo JF, Mayho M, Boinett C, Prasad D, Brickman TJ, Armstrong SK, Parkhill J, Da Silva Antunes R, Sette A, Papin JF, Wolf R, Merkel TJ. PMID: 36575950; PMCID: PMC10169431.
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T Cell Responses to SARS-CoV-2. Annu Rev Immunol. 2023 04 26; 41:343-373. Sette A, Sidney J, Crotty S. PMID: 36750314.
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Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies. bioRxiv. 2023 Feb 06. Painter MM, Johnston TS, Lundgreen KA, Santos JJS, Qin JS, Goel RR, Apostolidis SA, Mathew D, Fulmer B, Williams JC, McKeague ML, Pattekar A, Goode A, Nasta S, Baxter AE, Giles JR, Skelly AN, Felley LE, McLaughlin M, Weaver J, Penn Medicine BioBank, Kuthuru O, Dougherty J, Adamski S, Long S, Kee M, Clendenin C, da Silva Antunes R, Grifoni A, Weiskopf D, Sette A, Huang AC, Rader DJ, Hensley SE, Bates P, Greenplate AR, Wherry EJ. PMID: 36798171; PMCID: PMC9934532.
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Corrigendum: Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis. Front Immunol. 2023; 14:1141704. Du Bruyn E, Ruzive S, Howlett P, Cerrone M, Jacobs AJ, Lindestam Arlehamn CS, Sette A, Sher A, Mayer-Barber KD, Barber DL, Mayosi B, Ntsekhe M, Wilkinson RJ, Riou C. PMID: 36825021; PMCID: PMC9941733.
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Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life. medRxiv. 2023 Jan 31. Wimmers F, Burrell AR, Feng Y, Zheng H, Arunachalam PS, Hu M, Spranger S, Nyhoff L, Joshi D, Trisal M, Awasthi M, Bellusci L, Ashraf U, Kowli S, Konvinse KC, Yang E, Blanco M, Pellegrini K, Tharp G, Hagan T, Chinthrajah RS, Grifoni A, Sette A, Nadeau KC, Haslam DB, Bosinger SE, Wrammert J, Maecker HT, Utz PJ, Wang TT, Khurana S, Khatri P, Staat MA, Pulendran B. PMID: 36778389; PMCID: PMC9915811.
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Positive-strand RNA viruses-a Keystone Symposia report. Ann N Y Acad Sci. 2023 03; 1521(1):46-66. Cable J, Denison MR, Kielian M, Jackson WT, Bartenschlager R, Ahola T, Mukhopadhyay S, Fremont DH, Kuhn RJ, Shannon A, Frazier MN, Yuen KY, Coyne CB, Wolthers KC, Ming GL, Guenther CS, Moshiri J, Best SM, Schoggins JW, Jurado KA, Ebel GD, Schäfer A, Ng LFP, Kikkert M, Sette A, Harris E, Wing PAC, Eggenberger J, Krishnamurthy SR, Mah MG, Meganck RM, Chung D, Maurer-Stroh S, Andino R, Korber B, Perlman S, Shi PY, Bárcena M, Aicher SM, Vu MN, Kenney DJ, Lindenbach BD, Nishida Y, Rénia L, Williams EP. PMID: 36697369; PMCID: PMC10347887.
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The Cancer Epitope Database and Analysis Resource (CEDAR). Nucleic Acids Res. 2023 01 06; 51(D1):D845-D852. Kosaloglu-Yalçin Z, Blazeska N, Vita R, Carter H, Nielsen M, Schoenberger S, Sette A, Peters B. PMID: 36250634; PMCID: PMC9825495.
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Targets and cross-reactivity of human T cell recognition of Common Cold Coronaviruses. bioRxiv. 2023 Jan 05. Tarke A, Zhang Y, Methot N, Narowski TM, Phillips E, Mallal S, Frazier A, Filaci G, Weiskopf D, Dan JM, Premkumar L, Scheuermann RH, Sette A, Grifoni A. PMID: 36656777; PMCID: PMC9844015.
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IEDB and CEDAR: Two Sibling Databases to Serve the Global Scientific Community. Methods Mol Biol. 2023; 2673:133-149. Blazeska N, Kosaloglu-Yalcin Z, Vita R, Peters B, Sette A. PMID: 37258911; PMCID: PMC11008223.
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NIAID workshop on T cell technologies. Nat Immunol. 2023 01; 24(1):14-18. Gondré-Lewis TA, Jiang C, Ford ML, Koelle DM, Sette A, Shalek AK, Thomas PG. PMID: 36596894; PMCID: PMC10405620.
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SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines. Sci Immunol. 2022 12 23; 7(78):eadf1421. Bowen JE, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse KR, McCallum M, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Nguyen AW, Silva RP, Huang Y, Low JS, Jerak J, Tiles SW, Ahmed K, Shariq A, Dan JM, Zhang Z, Weiskopf D, Sette A, Snell G, Posavad CM, Iqbal NT, Geffner J, Bandera A, Gori A, Sallusto F, Maynard JA, Crotty S, Van Voorhis WC, Simmerling C, Grifantini R, Chu HY, Corti D, Veesler D. PMID: 36356052; PMCID: PMC9765460.
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Impact of SARS-CoV-2 exposure history on the T cell and IgG response. Cell Rep Med. 2023 01 17; 4(1):100898. Keeton R, Tincho MB, Suzuki A, Benede N, Ngomti A, Baguma R, Chauke MV, Mennen M, Skelem S, Adriaanse M, Grifoni A, Weiskopf D, Sette A, Bekker LG, Gray G, Ntusi NAB, Burgers WA, Riou C. PMID: 36584684; PMCID: PMC9771741.
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Bamlanivimab therapy for acute COVID-19 does not blunt SARS-CoV-2-specific memory T cell responses. JCI Insight. 2022 12 22; 7(24). Ramirez SI, Grifoni A, Weiskopf D, Parikh UM, Heaps A, Faraji F, Sieg SF, Ritz J, Moser C, Eron JJ, Currier JS, Klekotka P, Sette A, Wohl DA, Daar ES, Hughes MD, Chew KW, Smith DM, Crotty S, Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team. PMID: 36378539; PMCID: PMC9869965.
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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19. Cell Host Microbe. 2022 Dec 14; 30(12):1788. Grifoni A, Sidney J, Vita R, Peters B, Crotty S, Weiskopf D, Sette A. PMID: 36521443; PMCID: PMC9749374.
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Ad26.COV2.S priming provided a solid immunological base for mRNA-based COVID-19 booster vaccination. iScience. 2023 Jan 20; 26(1):105753. Geers D, Sablerolles RSG, van Baarle D, Kootstra NA, Rietdijk WJR, Schmitz KS, Gommers L, Bogers S, Nieuwkoop NJ, van Dijk LLA, van Haren E, Lafeber M, Dalm VASH, Goorhuis A, Postma DF, Visser LG, Huckriede ALW, Sette A, Grifoni A, de Swart RL, Koopmans MPG, van der Kuy PHM, GeurtsvanKessel CH, de Vries RD, SWITCH research group. PMID: 36507223; PMCID: PMC9726653.
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Durability of immune responses to the booster mRNA vaccination against COVID-19. medRxiv. 2022 Dec 04. Arunachalam PS, Lai L, Samaha H, Feng Y, Hu M, Hui HS, Wali B, Ellis M, Huerta C, Bechnack K, Bechnack S, Lee M, Litvack M, Losada C, Grifoni A, Sette A, Zarnitsyna VI, Rouphael N, Suthar MS, Pulendran B. PMID: 36482977; PMCID: PMC9727769.
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Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans. Cell Host Microbe. 2022 12 14; 30(12):1662-1670.e4. Grifoni A, Zhang Y, Tarke A, Sidney J, Rubiro P, Reina-Campos M, Filaci G, Dan JM, Scheuermann RH, Sette A. PMID: 36463861; PMCID: PMC9718645.
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Hybrid immunity in immunocompromised patients with CLL after SARS-CoV-2 infection followed by booster mRNA vaccination. Blood. 2022 12 01; 140(22):2403-2407. Blixt L, Gao Y, Wullimann D, Murén Ingelman-Sundberg H, Muschiol S, Healy K, Bogdanovic G, Pin E, Nilsson P, Kjellander C, Grifoni A, Sette A, Sällberg Chen M, Ljunggren HG, Buggert M, Hansson L, Österborg A. PMID: 36150168; PMCID: PMC9512527.
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Unaltered T cell responses to common antigens in individuals with Parkinson's disease. J Neurol Sci. 2023 01 15; 444:120510. Williams GP, Muskat K, Frazier A, Xu Y, Mateus J, Grifoni A, da Silva Antunes R, Weiskopf D, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Sulzer D, Lindestam Arlehamn CS, Sette A. PMID: 36495691; PMCID: PMC9950758.
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Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors. Cell Rep Methods. 2022 12 19; 2(12):100350. Yu ED, Wang E, Garrigan E, Sutherland A, Khalil N, Kearns K, Pham J, Schulten V, Peters B, Frazier A, Sette A, da Silva Antunes R. PMID: 36590684; PMCID: PMC9795325.
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Expression of specific HLA class II alleles is associated with an increased risk for active tuberculosis and a distinct gene expression profile. HLA. 2023 02; 101(2):124-137. Chihab LY, Kuan R, Phillips EJ, Mallal SA, Rozot V, Davis MM, Scriba TJ, Sette A, Peters B, Lindestam Arlehamn CS, SATVI Study Group. PMID: 36373948; PMCID: PMC10027422.
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Inactivated Vaccine-Induced SARS-CoV-2 Variant-Specific Immunity in Children. mBio. 2022 12 20; 13(6):e0131122. Soto JA, Melo-González F, Gutierrez-Vera C, Schultz BM, Berríos-Rojas RV, Rivera-Pérez D, Piña-Iturbe A, Hoppe-Elsholz G, Duarte LF, Vázquez Y, Moreno-Tapia D, Ríos M, Palacios PA, Garcia-Betancourt R, Santibañez Á, Pacheco GA, Mendez C, Andrade CA, Silva PH, Diethelm-Varela B, Astudillo P, Calvo M, Cárdenas A, González M, Goldsack M, Gutiérrez V, Potin M, Schilling A, Tapia LI, Twele L, Villena R, Grifoni A, Sette A, Weiskopf D, Fasce RA, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Acevedo ML, Valiente-Echeverría F, Soto-Rifo R, Retamal-Díaz A, Muñoz-Jofré N, PedCoronaVac03CL Study Group, , Meng X, Xin Q, Alarcón-Bustamante E, González-Aramundiz JV, Le Corre N, Álvarez-Figueroa MJ, González PA, Abarca K, Perret C, Carreño LJ, Bueno SM, Kalergis AM. PMID: 36383021; PMCID: PMC9765711.
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Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment. Cell Rep Med. 2022 12 20; 3(12):100833. Bosteels C, Van Damme KFA, De Leeuw E, Declercq J, Maes B, Bosteels V, Hoste L, Naesens L, Debeuf N, Deckers J, Cole B, Pardons M, Weiskopf D, Sette A, Weygaerde YV, Malfait T, Vandecasteele SJ, Demedts IK, Slabbynck H, Allard S, Depuydt P, Van Braeckel E, De Clercq J, Martens L, Dupont S, Seurinck R, Vandamme N, Haerynck F, Roychowdhury DF, Vandekerckhove L, Guilliams M, Tavernier SJ, Lambrecht BN. PMID: 36459994; PMCID: PMC9663750.
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Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis. Front Immunol. 2022; 13:1009016. Du Bruyn E, Ruzive S, Howlett P, Jacobs AJ, Arlehamn CSL, Sette A, Sher A, Mayer-Barber KD, Barber DL, Mayosi B, Ntsekhe M, Wilkinson RJ, Riou C. PMID: 36439130; PMCID: PMC9692124.
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Healthcare Worker Study Cohort to Determine the Level and Durability of Cellular and Humoral Immune Responses after Two Doses of SARS-CoV-2 Vaccination. Vaccines (Basel). 2022 Oct 24; 10(11). Dentone C, Fenoglio D, Ponzano M, Cerchiaro M, Altosole T, Franciotta D, Portunato F, Mikulska M, Taramasso L, Magnasco L, Uras C, Magne F, Ferrera F, Scavone G, Signori A, Vena A, Visconti V, Filaci G, Sette A, Grifoni A, Di Biagio A, Bassetti M. PMID: 36366293; PMCID: PMC9697204.
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Humoral and cellular immune responses to CoronaVac up to one year after vaccination. Front Immunol. 2022; 13:1032411. Costa PR, Correia CA, Marmorato MP, Dias JZC, Thomazella MV, Cabral da Silva A, de Oliveira ACS, Gusmão AF, Ferrari L, Freitas AC, Patiño EG, Grifoni A, Weiskopf D, Sette A, Scharf R, Kallás EG, Silveira CGT. PMID: 36341425; PMCID: PMC9634255.
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Differences in the immune response elicited by two immunization schedules with an inactivated SARS-CoV-2 vaccine in a randomized phase 3 clinical trial. Elife. 2022 10 13; 11. Gálvez NMS, Pacheco GA, Schultz BM, Melo-González F, Soto JA, Duarte LF, González LA, Rivera-Pérez D, Ríos M, Berrios RV, Vázquez Y, Moreno-Tapia D, Vallejos OP, Andrade CA, Hoppe-Elsholz G, Iturriaga C, Urzua M, Navarrete MS, Rojas Á, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Acevedo ML, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, CoronaVacCL03 Study Group, González-Aramundiz JV, Johnson M, Goldblatt D, González PA, Abarca K, Bueno SM, Kalergis AM. PMID: 36226829; PMCID: PMC9596164.
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NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responses. J Clin Invest. 2022 10 03; 132(19). Rydyznski Moderbacher C, Kim C, Mateus J, Plested J, Zhu M, Cloney-Clark S, Weiskopf D, Sette A, Fries L, Glenn G, Crotty S. PMID: 35943810; PMCID: PMC9525112.
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T-cell deficiency and hyperinflammatory monocyte responses associate with Mycobacterium avium complex lung disease. Front Immunol. 2022; 13:1016038. Lindestam Arlehamn CS, Benson B, Kuan R, Dill-McFarland KA, Peterson GJ, Paul S, Nguyen FK, Gilman RH, Saito M, Taplitz R, Arentz M, Goss CH, Aitken ML, Horne DJ, Shah JA, Sette A, Hawn TR. PMID: 36263044; PMCID: PMC9574438.
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Correlation of antigen-specific immune response with disease severity among COVID-19 patients in Bangladesh. Front Immunol. 2022; 13:929849. Bhuiyan TR, Al Banna H, Kaisar MH, Karmakar PC, Hakim A, Akter A, Ahmed T, Tauheed I, Islam S, Hasnat MA, Sumon MA, Rashed A, Ghosh S, Clemens JD, Banu S, Shirin T, Weiskopf D, Sette A, Chowdhury F, Qadri F. PMID: 36248882; PMCID: PMC9554593.
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Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern. iScience. 2022 Oct 21; 25(10):105202. Sun P, Ramos I, Coelho CH, Grifoni A, Balinsky CA, Vangeti S, Tarke A, Bloom NI, Jani V, Jakubski SJ, Boulifard DA, Cooper E, Goforth CW, Marayag J, Marrone A, Nunez E, White L, Porter CK, Sugiharto VA, Schilling M, Mahajan AS, Beckett C, Sette A, Sealfon SC, Crotty S, Letizia AG. PMID: 36168391; PMCID: PMC9502440.
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Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination. Nat Immunol. 2022 10; 23(10):1445-1456. Brasu N, Elia I, Russo V, Montacchiesi G, Stabile SA, De Intinis C, Fesi F, Gizzi K, Macagno M, Montone M, Mussolin B, Grifoni A, Faravelli S, Marchese S, Forneris F, De Francesco R, Sette A, Barnaba V, Sottile A, Sapino A, Pace L. PMID: 36138186.
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IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques. bioRxiv. 2022 Sep 15. Nelson CE, Foreman TW, Kauffman KD, Sakai S, Gould ST, Fleegle JD, Gomez F, NIAID/DIR Tuberculosis Imaging Program, Le Nouën C, Liu X, Burdette TL, Garza NL, Lafont BAP, Brooks K, Arlehamn CSL, Weiskopf D, Sette A, Hickman HD, Buchholz UJ, Johnson RF, Brenchley JM, Via LE, Barber DL. PMID: 36172119; PMCID: PMC9516850.
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Safety and Immunogenicity of an Inactivated Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine in a Subgroup of Healthy Adults in Chile. Clin Infect Dis. 2022 08 24; 75(1):e792-e804. Bueno SM, Abarca K, González PA, Gálvez NMS, Soto JA, Duarte LF, Schultz BM, Pacheco GA, González LA, Vázquez Y, Ríos M, Melo-González F, Rivera-Pérez D, Iturriaga C, Urzúa M, Domínguez A, Andrade CA, Berríos-Rojas RV, Canedo-Marroquín G, Covián C, Moreno-Tapia D, Saavedra F, Vallejos OP, Donato P, Espinoza P, Fuentes D, González M, Guzmán P, Muñoz Venturelli P, Pérez CM, Potin M, Rojas Á, Fasce RA, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Oyarzún-Arrau A, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Sette A, Zeng G, Meng W, González-Aramundiz JV, Kalergis AM. PMID: 34537835; PMCID: PMC9402626.
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Robust T-Cell Responses in Anti-CD20-Treated Patients Following COVID-19 Vaccination: A Prospective Cohort Study. Clin Infect Dis. 2022 08 24; 75(1):e1037-e1045. Madelon N, Lauper K, Breville G, Sabater Royo I, Goldstein R, Andrey DO, Grifoni A, Sette A, Kaiser L, Siegrist CA, Finckh A, Lalive PH, Didierlaurent AM, Eberhardt CS. PMID: 34791081; PMCID: PMC8767893.
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Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine. Sci Transl Med. 2022 08 17; 14(658):eabq4130. Arunachalam PS, Feng Y, Ashraf U, Hu M, Walls AC, Edara VV, Zarnitsyna VI, Aye PP, Golden N, Miranda MC, Green KWM, Threeton BM, Maness NJ, Beddingfield BJ, Bohm RP, Scheuermann SE, Goff K, Dufour J, Russell-Lodrigue K, Kepl E, Fiala B, Wrenn S, Ravichandran R, Ellis D, Carter L, Rogers K, Shirreff LM, Ferrell DE, Deb Adhikary NR, Fontenot J, Hammond HL, Frieman M, Grifoni A, Sette A, O'Hagan DT, Van Der Most R, Rappuoli R, Villinger F, Kleanthous H, Rappaport J, Suthar MS, Veesler D, Wang TT, King NP, Pulendran B. PMID: 35976993; PMCID: PMC10466502.
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Design and validation of HIV peptide pools for detection of HIV-specific CD4+ and CD8+ T cells. PLoS One. 2022; 17(8):e0268370. Al-Kolla R, Grifoni A, Crotty S, Sette A, Gianella S, Dan J. PMID: 35972938; PMCID: PMC9380920.
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Observations and Perspectives on Adaptive Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2022 08 15; 75(Suppl 1):S24-S29. Dan J, da Silva Antunes R, Grifoni A, Weiskopf D, Crotty S, Sette A. PMID: 35441229; PMCID: PMC9383833.
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A Booster Dose of CoronaVac Increases Neutralizing Antibodies and T Cells that Recognize Delta and Omicron Variants of Concern. mBio. 2022 08 30; 13(4):e0142322. Schultz BM, Melo-González F, Duarte LF, Gálvez NMS, Pacheco GA, Soto JA, Berríos-Rojas RV, González LA, Moreno-Tapia D, Rivera-Pérez D, Ríos M, Vázquez Y, Hoppe-Elsholz G, Andrade-Parra CA, Vallejos OP, Piña-Iturbe A, Iturriaga C, Urzua M, Navarrete MS, Rojas Á, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Acevedo ML, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, CoronaVac03CL Study Group, González-Aramundiz JV, González PA, Abarca K, Kalergis AM, Bueno SM. PMID: 35946814; PMCID: PMC9426482.
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Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med. 2022 08 10; 14(657):eabl9605. He WT, Yuan M, Callaghan S, Musharrafieh R, Song G, Silva M, Beutler N, Lee WH, Yong P, Torres JL, Melo M, Zhou P, Zhao F, Zhu X, Peng L, Huang D, Anzanello F, Ricketts J, Parren M, Garcia E, Ferguson M, Rinaldi W, Rawlings SA, Nemazee D, Smith DM, Briney B, Safonova Y, Rogers TF, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Irvine DJ, Ward AB, Wilson IA, Burton DR, Andrabi R. PMID: 35947674; PMCID: PMC10069796.
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From Alpha to omicron: The response of T cells. Curr Res Immunol. 2022; 3:146-150. Grifoni A, Sette A. PMID: 35966178; PMCID: PMC9364680.
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High-resolution analysis of individual spike peptide-specific CD4+ T-cell responses in vaccine recipients and COVID-19 patients. Clin Transl Immunology. 2022; 11(8):e1410. Karsten H, Cords L, Westphal T, Knapp M, Brehm TT, Hermanussen L, Omansen TF, Schmiedel S, Woost R, Ditt V, Peine S, Lütgehetmann M, Huber S, Ackermann C, Wittner M, Addo MM, Sette A, Sidney J, Schulze Zur Wiesch J. PMID: 35957961; PMCID: PMC9363231.
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A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes. Science. 2022 08 05; 377(6606):660-666. Bousbaine D, Fisch LI, London M, Bhagchandani P, Rezende de Castro TB, Mimee M, Olesen S, Reis BS, VanInsberghe D, Bortolatto J, Poyet M, Cheloha RW, Sidney J, Ling J, Gupta A, Lu TK, Sette A, Alm EJ, Moon JJ, Victora GD, Mucida D, Ploegh HL, Bilate AM. PMID: 35926021; PMCID: PMC9766740.
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Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic. Cell Host Microbe. 2022 09 14; 30(9):1269-1278.e4. Yu ED, Narowski TM, Wang E, Garrigan E, Mateus J, Frazier A, Weiskopf D, Grifoni A, Premkumar L, da Silva Antunes R, Sette A. PMID: 35932763; PMCID: PMC9296686.
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Omicron spike function and neutralizing activity elicited by a comprehensive panel of vaccines. Science. 2022 08 19; 377(6608):890-894. Bowen JE, Addetia A, Dang HV, Stewart C, Brown JT, Sharkey WK, Sprouse KR, Walls AC, Mazzitelli IG, Logue JK, Franko NM, Czudnochowski N, Powell AE, Dellota E, Ahmed K, Ansari AS, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Snell G, Grifantini R, Chu HY, Veesler D. PMID: 35857529; PMCID: PMC9348749.
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Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination. Immunity. 2022 09 13; 55(9):1732-1746.e5. Gao Y, Cai C, Wullimann D, Niessl J, Rivera-Ballesteros O, Chen P, Lange J, Cuapio A, Blennow O, Hansson L, Mielke S, Nowak P, Vesterbacka J, Akber M, Perez-Potti A, Sekine T, Müller TR, Boulouis C, Kammann T, Parrot T, Muvva JR, Sobkowiak M, Healy K, Bogdanovic G, Muschiol S, Söderdahl G, Österborg A, Hellgren F, Grifoni A, Weiskopf D, Sette A, Loré K, Sällberg Chen M, Ljungman P, Sandberg JK, Smith CIE, Bergman P, Ljunggren HG, Aleman S, Buggert M. PMID: 35961317; PMCID: PMC9293955.
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Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-COV-2 infection. AIDS. 2022 10 01; 36(12):F7-F16. Peluso MJ, Spinelli MA, Deveau TM, Forman CA, Munter SE, Mathur S, Tang AF, Lu S, Goldberg SA, Arreguin MI, Hoh R, Tai V, Chen JY, Martinez EO, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Sette A, Weiskopf D, Kumar N, Lynch KL, Hunt PW, Durstenfeld MS, Hsue PY, Kelly JD, Martin JN, Glidden DV, Gandhi M, Deeks SG, Rutishauser RL, Henrich TJ. PMID: 35866847; PMCID: PMC9444925.
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A comprehensive analysis of the IEDB MHC class-I automated benchmark. Brief Bioinform. 2022 07 18; 23(4). Trevizani R, Yan Z, Greenbaum JA, Sette A, Nielsen M, Peters B. PMID: 35794711; PMCID: PMC9618166.
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Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant. Front Immunol. 2022; 13:867577. Paul K, Sibbertsen F, Weiskopf D, Lütgehetmann M, Barroso M, Danecka MK, Glau L, Hecher L, Hermann K, Kohl A, Oh J, Schulze Zur Wiesch J, Sette A, Tolosa E, Vettorazzi E, Woidy M, Zapf A, Zazara DE, Mir TS, Muntau AC, Gersting SW, Dunay GA. PMID: 35911689; PMCID: PMC9336222.
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Humoral and cellular immune responses to CoronaVac assessed up to one year after vaccination. medRxiv. 2022 Jul 07. Costa PR, Correia CA, Marmorato MP, de Carvalho Dias JZ, Thomazella MV, da Silva AC, de Oliveira ACS, Gusmão AF, Ferrari L, Freitas AC, Patiño EG, Grifoni A, Weiskopf D, Sette A, Scharf R, Kallas EG, Terrassani Silveira CG. PMID: 35821982; PMCID: PMC9275662.
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Antigenic Determinants of SARS-CoV-2-Specific CD4+ T Cell Lines Reveals M Protein-Driven Dysregulation of Interferon Signaling. Front Immunol. 2022; 13:883159. Gazzinelli-Guimaraes PH, Sanku G, Sette A, Weiskopf D, Schaughency P, Lack J, Nutman TB. PMID: 35844575; PMCID: PMC9279651.
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Immunodominant MHC-II (Major Histocompatibility Complex II) Restricted Epitopes in Human Apolipoprotein B. Circ Res. 2022 07 22; 131(3):258-276. Roy P, Sidney J, Lindestam Arlehamn CS, Phillips E, Mallal S, Armstrong Suthahar SS, Billitti M, Rubiro P, Marrama D, Drago F, Vallejo J, Suryawanshi V, Orecchioni M, Makings J, Kim PJ, McNamara CA, Peters B, Sette A, Ley K. PMID: 35766025; PMCID: PMC9536649.
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T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells. Int J Mol Sci. 2022 Jun 29; 23(13). Hsieh LE, Song J, Grifoni A, Shimizu C, Tremoulet AH, Dummer KB, Burns JC, Sette A, Franco A. PMID: 35806225; PMCID: PMC9266459.
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Early and Polyantigenic CD4 T Cell Responses Correlate with Mild Disease in Acute COVID-19 Donors. Int J Mol Sci. 2022 Jun 28; 23(13). Tarke A, Potesta M, Varchetta S, Fenoglio D, Iannetta M, Sarmati L, Mele D, Dentone C, Bassetti M, Montesano C, Mondelli MU, Filaci G, Grifoni A, Sette A. PMID: 35806161; PMCID: PMC9267033.
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Predicting the Success of Fmoc-Based Peptide Synthesis. ACS Omega. 2022 Jul 12; 7(27):23771-23781. Gutman I, Gutman R, Sidney J, Chihab L, Mishto M, Liepe J, Chiem A, Greenbaum J, Yan Z, Sette A, Kosaloglu-Yalçin Z, Peters B. PMID: 35847273; PMCID: PMC9280948.
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Immunological memory to SARS-CoV-2 infection and COVID-19 vaccines. Immunol Rev. 2022 09; 310(1):27-46. Sette A, Crotty S. PMID: 35733376; PMCID: PMC9349657.
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Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern. Nat Microbiol. 2022 07; 7(7):974-985. Vikkurthi R, Ansari A, Pai AR, Jha SN, Sachan S, Pandit S, Nikam B, Kalia A, Jit BP, Parray HA, Singh S, Kshetrapal P, Wadhwa N, Shrivastava T, Coshic P, Kumar S, Sharma P, Sharma N, Taneja J, Pandey AK, Sharma A, Thiruvengadam R, Grifoni A, Weiskopf D, Sette A, Bhatnagar S, Gupta N. PMID: 35681012.
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Humoral and Cellular Response to Spike of Delta SARS-CoV-2 Variant in Vaccinated Patients With Multiple Sclerosis. Front Neurol. 2022; 13:881988. Petrone L, Tortorella C, Aiello A, Farroni C, Ruggieri S, Castilletti C, Meschi S, Cuzzi G, Vanini V, Palmieri F, Prosperini L, Haggiag S, Galgani S, Grifoni A, Sette A, Gasperini C, Nicastri E, Goletti D. PMID: 35711277; PMCID: PMC9194677.
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CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection. Cell Rep. 2022 05 31; 39(9):110896. Foreman TW, Nelson CE, Kauffman KD, Lora NE, Vinhaes CL, Dorosky DE, Sakai S, Gomez F, Fleegle JD, Parham M, Perera SR, Lindestam Arlehamn CS, Sette A, Tuberculosis Imaging Program, Brenchley JM, Queiroz ATL, Andrade BB, Kabat J, Via LE, Barber DL. PMID: 35649361.
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Humoral and cellular immune memory to four COVID-19 vaccines. Cell. 2022 07 07; 185(14):2434-2451.e17. Zhang Z, Mateus J, Coelho CH, Dan JM, Moderbacher CR, Gálvez RI, Cortes FH, Grifoni A, Tarke A, Chang J, Escarrega EA, Kim C, Goodwin B, Bloom NI, Frazier A, Weiskopf D, Sette A, Crotty S. PMID: 35764089; PMCID: PMC9135677.
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Bioinformatic and Experimental Analysis of T Cell Immune Reactivity to SARS-CoV-2 and its Variants. Front Bioinform. 2022; 2:876380. Tarke A, Grifoni A, Sette A. PMID: 36304267; PMCID: PMC9580847.
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Heterologous ChAdOx1/BNT162b2 vaccination induces stronger immune response than homologous ChAdOx1 vaccination: The pragmatic, multi-center, three-arm, partially randomized HEVACC trial. EBioMedicine. 2022 Jun; 80:104073. Bánki Z, Mateus J, Rössler A, Schäfer H, Bante D, Riepler L, Grifoni A, Sette A, Simon V, Falkensammer B, Ulmer H, Neurauter B, Borena W, HEVACC Study Group, Krammer F, von Laer D, Weiskopf D, Kimpel J. PMID: 35617826; PMCID: PMC9126042.
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SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents. Cell Rep Med. 2022 06 21; 3(6):100651. Garcia-Valtanen P, Hope CM, Masavuli MG, Yeow AEL, Balachandran H, Mekonnen ZA, Al-Delfi Z, Abayasingam A, Agapiou D, Stella AO, Aggarwal A, Bouras G, Gummow J, Ferguson C, O'Connor S, McCartney EM, Lynn DJ, Maddern G, Gowans EJ, Reddi BAJ, Shaw D, Kok-Lim C, Beard MR, Weiskopf D, Sette A, Turville SG, Bull RA, Barry SC, Grubor-Bauk B. PMID: 35654046; PMCID: PMC9110310.
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Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease. Nat Cardiovasc Res. 2022 May; 1(5):462-475. Saigusa R, Roy P, Freuchet A, Gulati R, Ghosheh Y, Suthahar SSA, Durant CP, Hanna DB, Kiosses WB, Orecchioni M, Wen L, Wu R, Kuniholm MH, Landay AL, Anastos K, Tien PC, Gange SJ, Kassaye S, Vallejo J, Hedrick CC, Kwok WW, Sette A, Hodis HN, Kaplan RC, Ley K. PMID: 35990517; PMCID: PMC9383695.
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An efficient immunoassay for the B cell help function of SARS-CoV-2-specific memory CD4+ T cells. Cell Rep Methods. 2022 06 20; 2(6):100224. Ansari A, Sachan S, Jit BP, Sharma A, Coshic P, Sette A, Weiskopf D, Gupta N. PMID: 35571764; PMCID: PMC9085463.
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Inducing broad-based immunity against viruses with pandemic potential. Immunity. 2022 05 10; 55(5):738-748. Sette A, Saphire EO. PMID: 35545026; PMCID: PMC10286218.
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Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases. Int J Infect Dis. 2022 Aug; 121:24-30. Petrone L, Picchianti-Diamanti A, Sebastiani GD, Aiello A, Laganà B, Cuzzi G, Vanini V, Gualano G, Grifoni A, Ferraioli M, Castilletti C, Meschi S, Vaia F, Nicastri E, Sette A, Goletti D. PMID: 35462039; PMCID: PMC9023365.
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Transcriptomics of Acute DENV-Specific CD8+ T Cells Does Not Support Qualitative Differences as Drivers of Disease Severity. Vaccines (Basel). 2022 Apr 14; 10(4). Grifoni A, Voic H, Yu ED, Mateus J, Yan Fung KM, Wang A, Seumois G, De Silva AD, Tennekon R, Premawansa S, Premawansa G, Tippalagama R, Wijewickrama A, Chawla A, Greenbaum J, Peters B, Pandurangan V, Weiskopf D, Sette A. PMID: 35455361; PMCID: PMC9029181.
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Author Correction: T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Nature. 2022 Apr; 604(7907):E25. Keeton R, Tincho MB, Ngomti A, Baguma R, Benede N, Suzuki A, Khan K, Cele S, Bernstein M, Karim F, Madzorera SV, Moyo-Gwete T, Mennen M, Skelem S, Adriaanse M, Mutithu D, Aremu O, Stek C, du Bruyn E, Van Der Mescht MA, de Beer Z, de Villiers TR, Bodenstein A, van den Berg G, Mendes A, Strydom A, Venter M, Giandhari J, Naidoo Y, Pillay S, Tegally H, Grifoni A, Weiskopf D, Sette A, Wilkinson RJ, de Oliveira T, Bekker LG, Gray G, Ueckermann V, Rossouw T, Boswell MT, Bhiman JN, Moore PL, Sigal A, Ntusi NAB, Burgers WA, Riou C. PMID: 35396582; PMCID: PMC8993033.
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Deciphering the quality of SARS-CoV-2 specific T-cell response associated with disease severity, immune memory and heterologous response. Clin Transl Med. 2022 04; 12(4):e802. Pérez-Gómez A, Gasca-Capote C, Vitallé J, Ostos FJ, Serna-Gallego A, Trujillo-Rodríguez M, Muñoz-Muela E, Giráldez-Pérez T, Praena-Segovia J, Navarro-Amuedo MD, Paniagua-García M, García-Gutiérrez M, Aguilar-Guisado M, Rivas-Jeremías I, Jiménez-León MR, Bachiller S, Fernández-Villar A, Pérez-González A, Gutiérrez-Valencia A, Rafii-El-Idrissi Benhnia M, Weiskopf D, Sette A, López-Cortés LF, Poveda E, Ruiz-Mateos E, Virgen del Rocío Hospital COVID-19 and COHVID-GS Working Teams. PMID: 35415890; PMCID: PMC9005926.
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Omicron-Specific Cytotoxic T-Cell Responses After a Third Dose of mRNA COVID-19 Vaccine Among Patients With Multiple Sclerosis Treated With Ocrelizumab. JAMA Neurol. 2022 04 01; 79(4):399-404. Madelon N, Heikkilä N, Sabater Royo I, Fontannaz P, Breville G, Lauper K, Goldstein R, Grifoni A, Sette A, Siegrist CA, Finckh A, Lalive PH, Didierlaurent AM, Eberhardt CS. PMID: 35212717; PMCID: PMC9002341.
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Preserved SARS-CoV-2 Vaccine Cell-Mediated Immunogenicity in Patients With Inflammatory Bowel Disease on Immune-Modulating Therapies. Clin Transl Gastroenterol. 2022 04 01; 13(4):e00484. Boland BS, Goodwin B, Zhang Z, Bloom N, Kato Y, Neill J, Le H, Tysl T, Collins AE, Dulai PS, Singh S, Nguyen NH, Grifoni A, Sette A, Weiskopf D, Chang JT, Dan JM. PMID: 35347100; PMCID: PMC9038482.
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Defining the risk of SARS-CoV-2 variants on immune protection. Nature. 2022 05; 605(7911):640-652. DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, Alter G, Amara RR, Baric RS, Barouch DH, Bloom JD, Bloyet LM, Bonenfant G, Boon ACM, Boritz EA, Bratt DL, Bricker TL, Brown L, Buchser WJ, Carreño JM, Cohen-Lavi L, Darling TL, Davis-Gardner ME, Dearlove BL, Di H, Dittmann M, Doria-Rose NA, Douek DC, Drosten C, Edara VV, Ellebedy A, Fabrizio TP, Ferrari G, Fischer WM, Florence WC, Fouchier RAM, Franks J, García-Sastre A, Godzik A, Gonzalez-Reiche AS, Gordon A, Haagmans BL, Halfmann PJ, Ho DD, Holbrook MR, Huang Y, James SL, Jaroszewski L, Jeevan T, Johnson RM, Jones TC, Joshi A, Kawaoka Y, Kercher L, Koopmans MPG, Korber B, Koren E, Koup RA, LeGresley EB, Lemieux JE, Liebeskind MJ, Liu Z, Livingston B, Logue JP, Luo Y, McDermott AB, McElrath MJ, Meliopoulos VA, Menachery VD, Montefiori DC, Mühlemann B, Munster VJ, Munt JE, Nair MS, Netzl A, Niewiadomska AM, O'Dell S, Pekosz A, Perlman S, Pontelli MC, Rockx B, Rolland M, Rothlauf PW, Sacharen S, Scheuermann RH, Schmidt SD, Schotsaert M, Schultz-Cherry S, Seder RA, Sedova M, Sette A, Shabman RS, Shen X, Shi PY, Shukla M, Simon V, Stumpf S, Sullivan NJ, Thackray LB, Theiler J, Thomas PG, Trifkovic S, Türeli S, Turner SA, Vakaki MA, van Bakel H, VanBlargan LA, Vincent LR, Wallace ZS, Wang L, Wang M, Wang P, Wang W, Weaver SC, Webby RJ, Weiss CD, Wentworth DE, Weston SM, Whelan SPJ, Whitener BM, Wilks SH, Xie X, Ying B, Yoon H, Zhou B, Hertz T, Smith DJ, Diamond MS, Post DJ, Suthar MS. PMID: 35361968; PMCID: PMC9345323.
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Divergent SARS-CoV-2 Omicron-reactive T and B cell responses in COVID-19 vaccine recipients. Sci Immunol. 2022 03 25; 7(69):eabo2202. GeurtsvanKessel CH, Geers D, Schmitz KS, Mykytyn AZ, Lamers MM, Bogers S, Scherbeijn S, Gommers L, Sablerolles RSG, Nieuwkoop NN, Rijsbergen LC, van Dijk LLA, de Wilde J, Alblas K, Breugem TI, Rijnders BJA, de Jager H, Weiskopf D, van der Kuy PHM, Sette A, Koopmans MPG, Grifoni A, Haagmans BL, de Vries RD. PMID: 35113647; PMCID: PMC8939771.
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Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures. NPJ Parkinsons Dis. 2022 Mar 21; 8(1):30. Dhanwani R, Lima-Junior JR, Sethi A, Pham J, Williams G, Frazier A, Xu Y, Amara AW, Standaert DG, Goldman JG, Litvan I, Alcalay RN, Peters B, Sulzer D, Arlehamn CSL, Sette A. PMID: 35314697; PMCID: PMC8938520.
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Humoral and cellular immune memory to four COVID-19 vaccines. bioRxiv. 2022 Mar 21. Zhang Z, Mateus J, Coelho CH, Dan JM, Moderbacher CR, Gálvez RI, Cortes FH, Grifoni A, Tarke A, Chang J, Escarrega EA, Kim C, Goodwin B, Bloom NI, Frazier A, Weiskopf D, Sette A, Crotty S. PMID: 35350195; PMCID: PMC8963692.
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Omicron BA.1 and BA.2 neutralizing activity elicited by a comprehensive panel of human vaccines. bioRxiv. 2022 Mar 16. Bowen JE, Sprouse KR, Walls AC, Mazzitelli IG, Logue JK, Franko NM, Ahmed K, Shariq A, Cameroni E, Gori A, Bandera A, Posavad CM, Dan JM, Zhang Z, Weiskopf D, Sette A, Crotty S, Iqbal NT, Corti D, Geffner J, Grifantini R, Chu HY, Veesler D. PMID: 35313570; PMCID: PMC8936098.
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Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues. Sci Immunol. 2022 03 10; eabo0535. Nelson CE, Namasivayam S, Foreman TW, Kauffman KD, Sakai S, Dorosky DE, Lora NE, NIAID/DIR Tuberculosis Imaging Program, Brooks K, Potter EL, Garza NL, Lafont BAP, Johnson RF, Roederer M, Sher A, Weiskopf D, Sette A, de Wit E, Hickman HD, Brenchley JM, Via LE, Barber DL. PMID: 35271298; PMCID: PMC8995035.
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Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial. Lancet Microbe. 2022 04; 3(4):e252-e264. Chiuppesi F, Zaia JA, Frankel PH, Stan R, Drake J, Williams B, Acosta AM, Francis K, Taplitz RA, Dickter JK, Dadwal S, Puing AG, Nanayakkara DD, Ash P, Cui Y, Contreras H, La Rosa C, Tiemann K, Park Y, Medina J, Iniguez A, Zhou Q, Karpinski V, Johnson D, Faircloth K, Kaltcheva T, Nguyen J, Kha M, Nguyen VH, Francisco SO, Grifoni A, Wong A, Sette A, Wussow F, Diamond DJ. PMID: 35287430; PMCID: PMC8906816.
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Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period. bioRxiv. 2022 Mar 02. Yu ED, Narowski TM, Wang E, Garrigan E, Mateus J, Frazier A, Weiskopf D, Grifoni A, Premkumar L, da Silva Antunes R, Sette A. PMID: 35262082; PMCID: PMC8902883.
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Limited induction of SARS-CoV-2-specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19. JCI Insight. 2022 02 22; 7(4). Singh V, Obregon-Perko V, Lapp SA, Horner AM, Brooks A, Macoy L, Hussaini L, Lu A, Gibson T, Silvestri G, Grifoni A, Weiskopf D, Sette A, Anderson EJ, Rostad CA, Chahroudi A. PMID: 35044955; PMCID: PMC8876428.
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Development of a T cell-based immunodiagnostic system to effectively distinguish SARS-CoV-2 infection and COVID-19 vaccination status. Cell Host Microbe. 2022 03 09; 30(3):388-399.e3. Yu ED, Wang E, Garrigan E, Goodwin B, Sutherland A, Tarke A, Chang J, Gálvez RI, Mateus J, Ramirez SI, Rawlings SA, Smith DM, Filaci G, Frazier A, Weiskopf D, Dan JM, Crotty S, Grifoni A, Sette A, da Silva Antunes R. PMID: 35172129; PMCID: PMC8824221.
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A booster dose of an inactivated SARS-CoV-2 vaccine increases neutralizing antibodies and T cells that recognize Delta and Omicron variants of concern. medRxiv. 2022 Feb 07. Schultz BM, Melo-González F, Duarte LF, Gálvez NM, Pacheco GA, Soto JA, Berríos-Rojas RV, González LA, Moreno-Tapia D, Rivera-Pérez D, Ríos M, Vázquez Y, Hoppe-Elsholz G, Vallejos OP, Iturriaga C, Urzua M, Navarrete MS, Rojas Á, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Acevedo M, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Grifoni A, Sette A, Zeng G, Meng W, CoronaVac03CL Study Group, González-Aramundiz JV, González PA, Abarca K, Kalergis AM, Bueno SM. PMID: 35441179; PMCID: PMC9016658.
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Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. Cell. 2022 03 17; 185(6):1008-1024.e15. Lederer K, Bettini E, Parvathaneni K, Painter MM, Agarwal D, Lundgreen KA, Weirick M, Muralidharan K, Castaño D, Goel RR, Xu X, Drapeau EM, Gouma S, Ort JT, Awofolaju M, Greenplate AR, Le Coz C, Romberg N, Trofe-Clark J, Malat G, Jones L, Rosen M, Weiskopf D, Sette A, Besharatian B, Kaminiski M, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. PMID: 35202565; PMCID: PMC8808747.
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Combined assessment of MHC binding and antigen abundance improves T cell epitope predictions. iScience. 2022 Feb 18; 25(2):103850. Kosaloglu-Yalçin Z, Lee J, Greenbaum J, Schoenberger SP, Miller A, Kim YJ, Sette A, Nielsen M, Peters B. PMID: 35128348; PMCID: PMC8806398.
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Minimal Information about MHC Multimers (MIAMM). J Immunol. 2022 02 01; 208(3):531-537. Vita R, Mody A, Overton JA, Buus S, Haley ST, Sette A, Mallajosyula V, Davis MM, Long DL, Willis RA, Peters B, Altman JD. PMID: 35042788; PMCID: PMC8830768.
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Trans-ancestral fine-mapping of MHC reveals key amino acids associated with spontaneous clearance of hepatitis C in HLA-DQβ1. Am J Hum Genet. 2022 02 03; 109(2):299-310. Valencia A, Vergara C, Thio CL, Vince N, Douillard V, Grifoni A, Cox AL, Johnson EO, Kral AH, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Price JC, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Wojcik GL, Carrington M, Gourraud PA, Sette A, Thomas DL, Duggal P. PMID: 35090584; PMCID: PMC8874224.
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T cell responses to SARS-CoV-2 spike cross-recognize Omicron. Nature. 2022 03; 603(7901):488-492. Keeton R, Tincho MB, Ngomti A, Baguma R, Benede N, Suzuki A, Khan K, Cele S, Bernstein M, Karim F, Madzorera SV, Moyo-Gwete T, Mennen M, Skelem S, Adriaanse M, Mutithu D, Aremu O, Stek C, du Bruyn E, Van Der Mescht MA, de Beer Z, de Villiers TR, Bodenstein A, van den Berg G, Mendes A, Strydom A, Venter M, Giandhari J, Naidoo Y, Pillay S, Tegally H, Grifoni A, Weiskopf D, Sette A, Wilkinson RJ, de Oliveira T, Bekker LG, Gray G, Ueckermann V, Rossouw T, Boswell MT, Bhiman JN, Moore PL, Sigal A, Ntusi NAB, Burgers WA, Riou C. PMID: 35102311; PMCID: PMC8930768.
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Involvement of Th1Th17 Cell Subpopulations in the Immune Responses of Mothers Who Gave Birth to Children with Congenital Zika Syndrome (CZS). Viruses. 2022 01 26; 14(2). Paiva IA, Familiar-Macedo D, Badolato-Corrêa J, Carvalho FR, Dias HG, Pauvolid-Corrêa A, Santos CFD, Silva AA, Azeredo EL, Vianna RAO, Cardoso CAA, Grifoni A, Sette A, Weiskopf D, de-Oliveira-Pinto LM. PMID: 35215843; PMCID: PMC8879837.
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Current Understanding of the Role of T Cells in Chikungunya, Dengue and Zika Infections. Viruses. 2022 01 25; 14(2). Mapalagamage M, Weiskopf D, Sette A, De Silva AD. PMID: 35215836; PMCID: PMC8878350.
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Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2. BMC Med. 2022 01 25; 20(1):32. Ukey R, Bruiners N, Mishra H, Mishra PK, McCloskey D, Onyuka A, Chen F, Pinter A, Weiskopf D, Sette A, Roy J, Gaur S, Gennaro ML. PMID: 35073931; PMCID: PMC8786593.
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SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron. Cell. 2022 03 03; 185(5):847-859.e11. Tarke A, Coelho CH, Zhang Z, Dan JM, Yu ED, Methot N, Bloom NI, Goodwin B, Phillips E, Mallal S, Sidney J, Filaci G, Weiskopf D, da Silva Antunes R, Crotty S, Grifoni A, Sette A. PMID: 35139340; PMCID: PMC8784649.
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Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant. Nat Med. 2022 03; 28(3):472-476. Gao Y, Cai C, Grifoni A, Müller TR, Niessl J, Olofsson A, Humbert M, Hansson L, Österborg A, Bergman P, Chen P, Olsson A, Sandberg JK, Weiskopf D, Price DA, Ljunggren HG, Karlsson AC, Sette A, Aleman S, Buggert M. PMID: 35042228; PMCID: PMC8938268.
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Lack of evidence of significant homology of SARS-CoV-2 spike sequences to myocarditis-associated antigens. EBioMedicine. 2022 Jan; 75:103807. Marrama D, Mahita J, Sette A, Peters B. PMID: 34998242; PMCID: PMC8733122.
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Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19. PLoS Pathog. 2022 Jan; 18(1):e1010220. Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, Marget M, Peine S, Johansson AM, Sette A, Lütgehetmann M, Kwok WW, Sidney J, Schulze Zur Wiesch J. PMID: 34986197; PMCID: PMC8730411.
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A Population of CD4+CD8+ Double-Positive T Cells Associated with Risk of Plasma Leakage in Dengue Viral Infection. Viruses. 2022 01 05; 14(1). Yu ED, Wang H, da Silva Antunes R, Tian Y, Tippalagama R, Alahakoon SU, Premawansa G, Wijewickrama A, Premawansa S, De Silva AD, Frazier A, Grifoni A, Sette A, Weiskopf D. PMID: 35062294; PMCID: PMC8779337.
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Central and Peripheral Inflammation: Connecting the Immune Responses of Parkinson's Disease. J Parkinsons Dis. 2022; 12(s1):S129-S136. Williams GP, Schonhoff AM, Sette A, Lindestam Arlehamn CS. PMID: 35754290; PMCID: PMC9535591.
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Detection of α-Synuclein-Specific T Cells in Parkinson's Disease. Methods Mol Biol. 2022; 2574:123-131. Dhanwani R, Sette A, Lindestam Arlehamn CS. PMID: 36087199.
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Epitope-Specific T Cell Receptor Data and Tools in the Immune Epitope Database. Methods Mol Biol. 2022; 2574:267-280. Chronister W, Sette A, Peters B. PMID: 36087207.
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T cells, α-synuclein and Parkinson disease. Handb Clin Neurol. 2022; 184:439-455. Garretti F, Monahan C, Sette A, Agalliu D, Sulzer D. PMID: 35034753; PMCID: PMC10193709.
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A promiscuous T cell epitope-based HIV vaccine providing redundant population coverage of the HLA class II elicits broad, polyfunctional T cell responses in nonhuman primates. Vaccine. 2022 01 21; 40(2):239-246. Ribeiro SP, De Moura Mattaraia VG, Almeida RR, Valentine EJG, Sales NS, Ferreira LCS, Sa-Rocha LC, Jacintho LC, Santana VC, Sidney J, Sette A, Rosa DS, Kalil J, Cunha-Neto E. PMID: 34961636.
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CD4+CCR6+ T cells dominate the BCG-induced transcriptional signature. EBioMedicine. 2021 Dec; 74:103746. Singhania A, Dubelko P, Kuan R, Chronister WD, Muskat K, Das J, Phillips EJ, Mallal SA, Seumois G, Vijayanand P, Sette A, Lerm M, Peters B, Lindestam Arlehamn C. PMID: 34902786; PMCID: PMC8671872.
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mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern. Science. 2021 Dec 03; 374(6572):abm0829. Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, UPenn COVID Processing Unit‡, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ. PMID: 34648302; PMCID: PMC9284784.
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Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex. Cell Rep. 2021 11 30; 37(9):110071. Poon MML, Byington E, Meng W, Kubota M, Matsumoto R, Grifoni A, Weiskopf D, Dogra P, Lam N, Szabo PA, Ural BB, Wells SB, Rosenfeld AM, Brusko MA, Brusko TM, Connors TJ, Sette A, Sims PA, Luning Prak ET, Shen Y, Farber DL. PMID: 34852222; PMCID: PMC8719595.
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SARS-CoV-2 infection generates tissue-localized immunological memory in humans. Sci Immunol. 2021 Nov 19; 6(65):eabl9105. Poon MML, Rybkina K, Kato Y, Kubota M, Matsumoto R, Bloom NI, Zhang Z, Hastie KM, Grifoni A, Weiskopf D, Wells SB, Ural BB, Lam N, Szabo PA, Dogra P, Lee YS, Gray JI, Bradley MC, Brusko MA, Brusko TM, Saphire EO, Connors TJ, Sette A, Crotty S, Farber DL. PMID: 34618554; PMCID: PMC8626868.
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High Frequencies of Functional Virus-Specific CD4+ T Cells in SARS-CoV-2 Subjects With Olfactory and Taste Disorders. Front Immunol. 2021; 12:748881. Mele D, Calastri A, Maiorano E, Cerino A, Sachs M, Oliviero B, Mantovani S, Baldanti F, Bruno R, Benazzo M, Grifoni A, Sette A, Mondelli MU, Varchetta S. PMID: 34858405; PMCID: PMC8631501.
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Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine. Front Immunol. 2021; 12:747830. Melo-González F, Soto JA, González LA, Fernández J, Duarte LF, Schultz BM, Gálvez NMS, Pacheco GA, Ríos M, Vázquez Y, Rivera-Pérez D, Moreno-Tapia D, Iturriaga C, Vallejos OP, Berríos-Rojas RV, Hoppe-Elsholz G, Urzúa M, Bruneau N, Fasce RA, Mora J, Grifoni A, Sette A, Weiskopf D, Zeng G, Meng W, González-Aramundiz JV, González PA, Abarca K, Ramírez E, Kalergis AM, Bueno SM. PMID: 34858404; PMCID: PMC8630786.
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Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response. Clin Infect Dis. 2021 11 02; 73(9):e3130-e3132. Murugesan K, Jagannathan P, Pham TD, Pandey S, Bonilla HF, Jacobson K, Parsonnet J, Andrews JR, Weiskopf D, Sette A, Pinsky BA, Singh U, Banaei N. PMID: 33035306; PMCID: PMC7665338.
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Characterization of a library of 20 HBV-specific MHC class II-restricted T cell receptors. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:476-489. Schreiber S, Honz M, Mamozai W, Kurktschiev P, Schiemann M, Witter K, Moore E, Zielinski C, Sette A, Protzer U, Wisskirchen K. PMID: 34853796; PMCID: PMC8605085.
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CD8+ T cells specific for cryptic apoptosis-associated epitopes exacerbate experimental autoimmune encephalomyelitis. Cell Death Dis. 2021 10 29; 12(11):1026. Feizi N, Focaccetti C, Pacella I, Tucci G, Rossi A, Costanza M, Pedotti R, Sidney J, Sette A, La Rocca C, Procaccini C, Matarese G, Barnaba V, Piconese S. PMID: 34716313; PMCID: PMC8556378.
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Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells. Science. 2021 Oct 22; 374(6566):eabj9853. Mateus J, Dan JM, Zhang Z, Rydyznski Moderbacher C, Lammers M, Goodwin B, Sette A, Crotty S, Weiskopf D. PMID: 34519540; PMCID: PMC8542617.
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Risk assessment of latent tuberculosis infection through a multiplexed cytokine biosensor assay and machine learning feature selection. Sci Rep. 2021 10 15; 11(1):20544. Robison HM, Chapman CA, Zhou H, Erskine CL, Theel E, Peikert T, Lindestam Arlehamn CS, Sette A, Bushell C, Welge M, Zhu R, Bailey RC, Escalante P. PMID: 34654869; PMCID: PMC8520014.
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Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner. Cell Host Microbe. 2021 11 10; 29(11):1611-1619.e5. Keeton R, Richardson SI, Moyo-Gwete T, Hermanus T, Tincho MB, Benede N, Manamela NP, Baguma R, Makhado Z, Ngomti A, Motlou T, Mennen M, Chinhoyi L, Skelem S, Maboreke H, Doolabh D, Iranzadeh A, Otter AD, Brooks T, Noursadeghi M, Moon JC, Grifoni A, Weiskopf D, Sette A, Blackburn J, Hsiao NY, Williamson C, Riou C, Goga A, Garrett N, Bekker LG, Gray G, Ntusi NAB, Moore PL, Burgers WA. PMID: 34688376; PMCID: PMC8511649.
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Heterogeneity of magnitude, allergen immunodominance, and cytokine polarization of cockroach allergen-specific T cell responses in allergic sensitized children. Clin Transl Allergy. 2021 Oct; 11(8):e12073. da Silva Antunes R, Sutherland A, Frazier A, Schulten V, Pomés A, Glesner J, Calatroni A, Altman MC, Wood RA, O'Connor GT, Pongracic JA, Khurana Hershey GK, Kercsmar CM, Gruchalla RS, Gill M, Liu AH, Zoratti E, Kattan M, Busse PJ, Bacharier LB, Teach SJ, Wheatley LM, Togias A, Busse WW, Jackson DJ, Sette A. PMID: 34691392; PMCID: PMC8514843.
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Dichotomy between the humoral and cellular responses elicited by mRNA and adenoviral vector vaccines against SARS-CoV-2. medRxiv. 2021 Sep 21. Ukey R, Bruiners N, Mishra H, Mishra PK, McCloskey D, Onyuka A, Chen F, Pinter A, Weiskopf D, Sette A, Roy J, Gaur S, Gennaro ML. PMID: 34580675; PMCID: PMC8475964.
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Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals. medRxiv. 2021 Sep 21. Lederer K, Parvathaneni K, Painter MM, Bettini E, Agarwal D, Lundgreen KA, Weirick M, Goel RR, Xu X, Drapeau EM, Gouma S, Greenplate AR, Coz CL, Romberg N, Jones L, Rosen M, Besharatian B, Kaminiski M, Weiskopf D, Sette A, Hensley SE, Bates P, Wherry EJ, Naji A, Bhoj V, Locci M. PMID: 34580676; PMCID: PMC8475965.
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Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19. PLoS Pathog. 2021 09; 17(9):e1009842. Heide J, Schulte S, Kohsar M, Brehm TT, Herrmann M, Karsten H, Marget M, Peine S, Johansson AM, Sette A, Lütgehetmann M, Kwok WW, Sidney J, Schulze Zur Wiesch J. PMID: 34529740; PMCID: PMC8445433.
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Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted. Blood Adv. 2021 09 14; 5(17):3309-3321. Rubinstein JD, Zhu X, Leemhuis T, Pham G, Ray L, Emberesh S, Jodele S, Thomas S, Cancelas JA, Bollard CM, Hanley PJ, Keller MD, Grimley O, Clark D, Clark T, Lindestam Arlehamn CS, Sette A, Davies SM, Nelson AS, Grimley MS, Lutzko C. PMID: 34473237; PMCID: PMC8525242.
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Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat Med. 2021 11; 27(11):1990-2001. Apostolidis SA, Kakara M, Painter MM, Goel RR, Mathew D, Lenzi K, Rezk A, Patterson KR, Espinoza DA, Kadri JC, Markowitz DM, E Markowitz C, Mexhitaj I, Jacobs D, Babb A, Betts MR, Prak ETL, Weiskopf D, Grifoni A, Lundgreen KA, Gouma S, Sette A, Bates P, Hensley SE, Greenplate AR, Wherry EJ, Li R, Bar-Or A. PMID: 34522051; PMCID: PMC8604727.
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Identification and Characterization of Rift Valley Fever Virus-Specific T Cells Reveals a Dependence on CD40/CD40L Interactions for Prevention of Encephalitis. J Virol. 2021 11 09; 95(23):e0150621. Barbeau DJ, Cartwright HN, Harmon JR, Spengler JR, Spiropoulou CF, Sidney J, Sette A, McElroy AK. PMID: 34495703; PMCID: PMC8577384.
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Characterization of Conserved and Promiscuous Human Rhinovirus CD4 T Cell Epitopes. Cells. 2021 09 02; 10(9). Gomez-Perosanz M, Fiyouzi T, Fernandez-Arquero M, Sidney J, Sette A, Reinherz EL, Lafuente EM, Reche PA. PMID: 34571943; PMCID: PMC8471592.
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Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer. Nature. 2021 09; 597(7875):279-284. Eberhardt CS, Kissick HT, Patel MR, Cardenas MA, Prokhnevska N, Obeng RC, Nasti TH, Griffith CC, Im SJ, Wang X, Shin DM, Carrington M, Chen ZG, Sidney J, Sette A, Saba NF, Wieland A, Ahmed R. PMID: 34471285; PMCID: PMC10201342.
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The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community. Front Immunol. 2021; 12:735609. Kosaloglu-Yalçin Z, Blazeska N, Carter H, Nielsen M, Cohen E, Kufe D, Conejo-Garcia J, Robbins P, Schoenberger SP, Peters B, Sette A. PMID: 34504503; PMCID: PMC8421848.
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mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern. bioRxiv. 2021 Aug 23. Goel RR, Painter MM, Apostolidis SA, Mathew D, Meng W, Rosenfeld AM, Lundgreen KA, Reynaldi A, Khoury DS, Pattekar A, Gouma S, Kuri-Cervantes L, Hicks P, Dysinger S, Hicks A, Sharma H, Herring S, Korte S, Baxter AE, Oldridge DA, Giles JR, Weirick ME, McAllister CM, Awofolaju M, Tanenbaum N, Drapeau EM, Dougherty J, Long S, D'Andrea K, Hamilton JT, McLaughlin M, Williams JC, Adamski S, Kuthuru O, UPenn COVID Processing Unit, Frank I, Betts MR, Vella LA, Grifoni A, Weiskopf D, Sette A, Hensley SE, Davenport MP, Bates P, Luning Prak ET, Greenplate AR, Wherry EJ. PMID: 34462751; PMCID: PMC8404899.
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Generation of a Novel SARS-CoV-2 Sub-genomic RNA Due to the R203K/G204R Variant in Nucleocapsid: Homologous Recombination has Potential to Change SARS-CoV-2 at Both Protein and RNA Level. Pathog Immun. 2021; 6(2):27-49. Leary S, Gaudieri S, Parker MD, Chopra A, James I, Pakala S, Alves E, John M, Lindsey BB, Keeley AJ, Rowland-Jones SL, Swanson MS, Ostrov DA, Bubenik JL, Das SR, Sidney J, Sette A, COVID-19 Genomics UK (COG-UK) consortium, de Silva TI, Phillips E, Mallal S. PMID: 34541432; PMCID: PMC8439434.
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PopCover-2.0. Improved Selection of Peptide Sets With Optimal HLA and Pathogen Diversity Coverage. Front Immunol. 2021; 12:728936. Nilsson JB, Grifoni A, Tarke A, Sette A, Nielsen M. PMID: 34484239; PMCID: PMC8416060.
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Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination. Immunity. 2021 09 14; 54(9):2133-2142.e3. Painter MM, Mathew D, Goel RR, Apostolidis SA, Pattekar A, Kuthuru O, Baxter AE, Herati RS, Oldridge DA, Gouma S, Hicks P, Dysinger S, Lundgreen KA, Kuri-Cervantes L, Adamski S, Hicks A, Korte S, Giles JR, Weirick ME, McAllister CM, Dougherty J, Long S, D'Andrea K, Hamilton JT, Betts MR, Bates P, Hensley SE, Grifoni A, Weiskopf D, Sette A, Greenplate AR, Wherry EJ. PMID: 34453880; PMCID: PMC8361141.
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Profiling Human Cytomegalovirus-Specific T Cell Responses Reveals Novel Immunogenic Open Reading Frames. J Virol. 2021 10 13; 95(21):e0094021. Dhanwani R, Dhanda SK, Pham J, Williams GP, Sidney J, Grifoni A, Picarda G, Lindestam Arlehamn CS, Sette A, Benedict CA. PMID: 34379494; PMCID: PMC8513490.
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Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level. bioRxiv. 2021 Aug 06. Leary S, Gaudieri S, Parker MD, Chopra A, James I, Pakala S, Alves E, John M, Lindsey BB, Keeley AJ, Rowland-Jones SL, Swanson MS, Ostrov DA, Bubenik JL, Das S, Sidney J, Sette A, COVID-19 Genomics UK (COG-UK) consortium, de Silva TI, Phillips E, Mallal S. PMID: 33880475; PMCID: PMC8057240.
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Allele-Specific Thresholds of Eluted Ligands for T-Cell Epitope Prediction. Mol Cell Proteomics. 2021; 20:100122. Reardon B, Kosaloglu-Yalçin Z, Paul S, Peters B, Sette A. PMID: 34303001; PMCID: PMC8724920.
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A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. PMID: 34266981; PMCID: PMC9119307.
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The potential clinical utility of measuring severe acute respiratory syndrome coronavirus 2-specific T-cell responses. Clin Microbiol Infect. 2021 Dec; 27(12):1784-1789. Goletti D, Petrone L, Manissero D, Bertoletti A, Rao S, Ndunda N, Sette A, Nikolayevskyy V. PMID: 34256141; PMCID: PMC8272618.
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Evaluation of ELISA-Based Multiplex Peptides for the Detection of Human Serum Antibodies Induced by Zika Virus Infection across Various Countries. Viruses. 2021 07 08; 13(7). Martinez Viedma MDP, Panossian S, Gifford K, García K, Figueroa I, Parham L, de Moraes L, Nunes Gomes L, García-Salum T, Perret C, Weiskopf D, Tan GS, Augusto Silva A, Boaventura V, Ruiz-Palacios GM, Sette A, De Silva AD, Medina RA, Lorenzana I, Akrami KM, Khouri R, Olson D, Pickett BE. PMID: 34372525; PMCID: PMC8310037.
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Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals. Cell Rep Med. 2021 07 20; 2(7):100355. Tarke A, Sidney J, Methot N, Yu ED, Zhang Y, Dan JM, Goodwin B, Rubiro P, Sutherland A, Wang E, Frazier A, Ramirez SI, Rawlings SA, Smith DM, da Silva Antunes R, Peters B, Scheuermann RH, Weiskopf D, Crotty S, Grifoni A, Sette A. PMID: 34230917; PMCID: PMC8249675.
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Differential T-Cell Reactivity to Endemic Coronaviruses and SARS-CoV-2 in Community and Health Care Workers. J Infect Dis. 2021 07 02; 224(1):70-80. da Silva Antunes R, Pallikkuth S, Williams E, Dawen Yu E, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A. PMID: 33822097; PMCID: PMC8083569.
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HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients. J Immunol. 2021 07 15; 207(2):523-533. Tippalagama R, Singhania A, Dubelko P, Lindestam Arlehamn CS, Crinklaw A, Pomaznoy M, Seumois G, deSilva AD, Premawansa S, Vidanagama D, Gunasena B, Goonawardhana NDS, Ariyaratne D, Scriba TJ, Gilman RH, Saito M, Taplitz R, Vijayanand P, Sette A, Peters B, Burel JG. PMID: 34193602; PMCID: PMC8516689.
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Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates. Mucosal Immunol. 2021 09; 14(5):1055-1066. Sakai S, Lora NE, Kauffman KD, Dorosky DE, Oh S, Namasivayam S, Gomez F, Fleegle JD, Tuberculosis Imaging Program, Arlehamn CSL, Sette A, Sher A, Freeman GJ, Via LE, Barry Iii CE, Barber DL. PMID: 34158594; PMCID: PMC8217205.
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Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals. Sci Immunol. 2021 06 18; 6(60). Jin J, Kim C, Xia Q, Gould TM, Cao W, Zhang H, Li X, Weiskopf D, Grifoni A, Sette A, Weyand CM, Goronzy JJ. PMID: 34145066; PMCID: PMC8422387.
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Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection. J Clin Invest. 2021 06 15; 131(12). Riou C, du Bruyn E, Stek C, Daroowala R, Goliath RT, Abrahams F, Said-Hartley Q, Allwood BW, Hsiao NY, Wilkinson KA, Arlehamn CSL, Sette A, Wasserman S, Wilkinson RJ, HIATUS consortium. PMID: 33945513; PMCID: PMC8203446.
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Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs. Cell. 2021 07 22; 184(15):3962-3980.e17. Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Gallagher KME, Bauer MR, Taylor HB, Dunn WA, Tarr C, Sidney J, Rachimi S, Conway HL, Katsis K, Wang Y, Leistritz-Edwards D, Durkin MR, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Carulli IP, Chea VA, Chandrashekar A, Bozkus CC, Carrington M, MGH COVID-19 Collection & Processing Team, Bhardwaj N, Barouch DH, Sette A, Maus MV, Rice CM, Clauser KR, Keskin DB, Pregibon DC, Hacohen N, Carr SA, Abelin JG, Saeed M, Sabeti PC. PMID: 34171305; PMCID: PMC8173604.
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Pre-existing T Cell Memory against Zika Virus. J Virol. 2021 05 24; 95(12). Schouest B, Grifoni A, Pham J, Mateus J, Sydney J, Brien JD, De Silva AD, Balmaseda A, Harris E, Sette A, Weiskopf D. PMID: 33789994; PMCID: PMC8316092.
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SARS-CoV-2 human T cell epitopes: Adaptive immune response against COVID-19. Cell Host Microbe. 2021 07 14; 29(7):1076-1092. Grifoni A, Sidney J, Vita R, Peters B, Crotty S, Weiskopf D, Sette A. PMID: 34237248; PMCID: PMC8139264.
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Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung. J Clin Invest. 2021 05 17; 131(10). Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ng'oepe A, Karim F, Naidoo T, Khan K, Dullabh KJ, Fehlings M, Lee BH, Nardin A, Lindestam Arlehamn CS, Sette A, Behar SM, Steyn AJ, Madansein R, Kløverpris HN, Elkington PT, Leslie A. PMID: 33848273; PMCID: PMC8121523.
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The Longest Persistence of Viable SARS-CoV-2 With Recurrence of Viremia and Relapsing Symptomatic COVID-19 in an Immunocompromised Patient-A Case Study. Open Forum Infect Dis. 2021 Nov; 8(11):ofab217. Sepulcri C, Dentone C, Mikulska M, Bruzzone B, Lai A, Fenoglio D, Bozzano F, Bergna A, Parodi A, Altosole T, Delfino E, Bartalucci G, Orsi A, Di Biagio A, Zehender G, Ballerini F, Bonora S, Sette A, De Palma R, Silvestri G, De Maria A, Bassetti M. PMID: 34796242; PMCID: PMC8135455.
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Balanced Cellular and Humoral Immune Responses Targeting Multiple Antigens in Adults Receiving a Quadrivalent Inactivated Influenza Vaccine. Vaccines (Basel). 2021 Apr 23; 9(5). Yu ED, Grifoni A, Sutherland A, Voic H, Wang E, Frazier A, Jimenez-Truque N, Yoder S, Welsh S, Wooden S, Koff W, Creech B, Sette A, da Silva Antunes R. PMID: 33922875; PMCID: PMC8146362.
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Backbone Modifications of HLA-A2-Restricted Antigens Induce Diverse Binding and T Cell Activation Outcomes. J Am Chem Soc. 2021 05 05; 143(17):6470-6481. Gibadullin R, Randall CJ, Sidney J, Sette A, Gellman SH. PMID: 33881854; PMCID: PMC8111684.
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A system-view of Bordetella pertussis booster vaccine responses in adults primed with whole-cell versus acellular vaccine in infancy. JCI Insight. 2021 04 08; 6(7). da Silva Antunes R, Soldevila F, Pomaznoy M, Babor M, Bennett J, Tian Y, Khalil N, Qian Y, Mandava A, Scheuermann RH, Cortese M, Pulendran B, Petro CD, Gilkes AP, Purcell LA, Sette A, Peters B. PMID: 33690224; PMCID: PMC8119213.
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T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. Nat Commun. 2021 04 06; 12(1):2055. Ogbe A, Kronsteiner B, Skelly DT, Pace M, Brown A, Adland E, Adair K, Akhter HD, Ali M, Ali SE, Angyal A, Ansari MA, Arancibia-Cárcamo CV, Brown H, Chinnakannan S, Conlon C, de Lara C, de Silva T, Dold C, Dong T, Donnison T, Eyre D, Flaxman A, Fletcher H, Gardner J, Grist JT, Hackstein CP, Jaruthamsophon K, Jeffery K, Lambe T, Lee L, Li W, Lim N, Matthews PC, Mentzer AJ, Moore SC, Naisbitt DJ, Ogese M, Ogg G, Openshaw P, Pirmohamed M, Pollard AJ, Ramamurthy N, Rongkard P, Rowland-Jones S, Sampson O, Screaton G, Sette A, Stafford L, Thompson C, Thomson PJ, Thwaites R, Vieira V, Weiskopf D, Zacharopoulou P, Oxford Immunology Network Covid-19 Response T Cell Consortium, Oxford Protective T Cell Immunology for COVID-19 (OPTIC) Clinical Team, Turtle L, Klenerman P, Goulder P, Frater J, Barnes E, Dunachie S. PMID: 33824342; PMCID: PMC8024333.
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Interim report: Safety and immunogenicity of an inactivated vaccine against SARS-CoV-2 in healthy chilean adults in a phase 3 clinical trial. medRxiv. 2021 Apr 01. Bueno SM, Abarca K, González PA, Gálvez NM, Soto JA, Duarte LF, Schultz BM, Pacheco GA, González LA, Vázquez Y, Ríos M, Melo-González F, Rivera-Pérez D, Iturriaga C, Urzúa M, Dominguez A, Andrade CA, Berrios RV, Canedo-Marroquín G, Covián C, Moreno-Tapia D, Saavedra F, Vallejos OP, Donato P, Espinoza P, Fuentes D, González M, Guzmán P, Muñoz-Venturelli P, Pérez CM, Potin M, Rojas A, Fasce R, Fernández J, Mora J, Ramírez E, Gaete-Argel A, Oyarzún-Arrau A, Valiente-Echeverría F, Soto-Rifo R, Weiskopf D, Sette A, Zeng G, Meng W, González-Aramundiz JV, Kalergis AM. PMID: 35441164; PMCID: PMC9016657.
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An immunologically friendly classification of non-peptidic ligands. Database (Oxford). 2021 03 27; 2021. Edwards L, Jackson R, Overton JA, Vita R, Blazeska N, Peters B, Sette A. PMID: 33772585; PMCID: PMC8001080.
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Development of nasal allergen challenge with cockroach in children with asthma. Pediatr Allergy Immunol. 2021 07; 32(5):971-979. Rudman Spergel AK, Sever ML, Johnson J, Gill MA, Schulten V, Frazier A, Kercsmar CM, Lovinsky-Desir S, Searing DA, Sette A, Shao B, Teach SJ, Gern JE, Busse WW, Togias A, Wood RA, Liu AH, National Institute of Allergy and Infectious Diseases Inner City Asthma Consortium. PMID: 33606312; PMCID: PMC8503840.
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Immune Memory in Mild COVID-19 Patients and Unexposed Donors Reveals Persistent T Cell Responses After SARS-CoV-2 Infection. Front Immunol. 2021; 12:636768. Ansari A, Arya R, Sachan S, Jha SN, Kalia A, Lall A, Sette A, Grifoni A, Weiskopf D, Coshic P, Sharma A, Gupta N. PMID: 33777028; PMCID: PMC7991090.
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TCRMatch: Predicting T-Cell Receptor Specificity Based on Sequence Similarity to Previously Characterized Receptors. Front Immunol. 2021; 12:640725. Chronister WD, Crinklaw A, Mahajan S, Vita R, Kosaloglu-Yalçin Z, Yan Z, Greenbaum JA, Jessen LE, Nielsen M, Christley S, Cowell LG, Sette A, Peters B. PMID: 33777034; PMCID: PMC7991084.
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Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2. Int J Infect Dis. 2021 Dec; 113 Suppl 1:S82-S87. Petrone L, Petruccioli E, Vanini V, Cuzzi G, Gualano G, Vittozzi P, Nicastri E, Maffongelli G, Grifoni A, Sette A, Ippolito G, Migliori GB, Palmieri F, Goletti D. PMID: 33713816; PMCID: PMC7944764.
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Classical CD4 T cells as the cornerstone of antimycobacterial immunity. Immunol Rev. 2021 05; 301(1):10-29. Morgan J, Muskat K, Tippalagama R, Sette A, Burel J, Lindestam Arlehamn CS. PMID: 33751597; PMCID: PMC8252593.
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Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees. bioRxiv. 2021 Mar 01. Tarke A, Sidney J, Methot N, Zhang Y, Dan JM, Goodwin B, Rubiro P, Sutherland A, da Silva Antunes R, Frazier A, Rawlings SA, Smith DM, Peters B, Scheuermann RH, Weiskopf D, Crotty S, Grifoni A, Sette A. PMID: 33688655; PMCID: PMC7941626.
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Immune memory in mild COVID-19 patients and unexposed donors from India reveals persistent T cell responses after SARS-CoV-2 infection. medRxiv. 2021 Feb 26. Ansari A, Arya R, Sachan S, Jha SN, Kalia A, Lall A, Sette A, Grifoni A, Weiskopf D, Coshic P, Sharma A, Gupta N. PMID: 33655267; PMCID: PMC7924292.
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B cells modulate mouse allergen-specific T cells in nonallergic laboratory animal-care workers. JCI Insight. 2021 02 22; 6(4). Yu ED, Westernberg L, Grifoni A, Frazier A, Sutherland A, Wang E, Peters B, da Silva Antunes R, Sette A. PMID: 33616085; PMCID: PMC7934936.
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The role of immune-mediated alterations and disorders in ALS disease. Hum Immunol. 2021 Mar; 82(3):155-161. Rodrigues Lima-Junior J, Sulzer D, Lindestam Arlehamn CS, Sette A. PMID: 33583639; PMCID: PMC7942756.
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Differential Longevity of Memory CD4 and CD8 T Cells in a Cohort of the Mothers With a History of ZIKV Infection and Their Children. Front Immunol. 2021; 12:610456. Badolato-Corrêa J, Carvalho FR, Paiva IA, Familiar-Macedo D, Dias HG, Pauvolid-Corrêa A, Fernandes-Santos C, Lima MDRQ, Gandini M, Silva AA, Baeta Cavalcanti SM, de Oliveira SA, de Oliveira Vianna RA, de Azeredo EL, Cardoso CAA, Grifoni A, Sette A, Weiskopf D, de-Oliveira-Pinto LM. PMID: 33679748; PMCID: PMC7928292.
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IgG Epitopes Processed and Presented by IgG+ B Cells Induce Suppression by Human Thymic-Derived Regulatory T Cells. J Immunol. 2021 03 15; 206(6):1194-1203. Hsieh LE, Sidney J, Burns JC, Boyle DL, Firestein GS, Altman Y, Sette A, Franco A. PMID: 33579724; PMCID: PMC7939040.
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IgE and T Cell Reactivity to a Comprehensive Panel of Cockroach Allergens in Relation to Disease. Front Immunol. 2020; 11:621700. Pomés A, Schulten V, Glesner J, da Silva Antunes R, Sutherland A, Bacharier LB, Beigelman A, Busse P, Frazier A, Sette A. PMID: 33643303; PMCID: PMC7902920.
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Functional Analysis of Immune Signature Genes in Th1* Memory Cells Links ISOC1 and Pyrimidine Metabolism to IFN-γ and IL-17 Production. J Immunol. 2021 03 15; 206(6):1181-1193. Kushnareva Y, Mathews IT, Andreyev AY, Altay G, Lindestam Arlehamn CS, Pandurangan V, Nilsson R, Jain M, Sette A, Peters B, Sharma S. PMID: 33547171; PMCID: PMC7946769.
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Evaluation of the Expression of CCR5 and CX3CR1 Receptors and Correlation with the Functionality of T Cells in Women infected with ZIKV during Pregnancy. Viruses. 2021 01 28; 13(2). Familiar-Macedo D, Amancio Paiva I, Badolato-Corrêa da Silva J, de Carvalho FR, Dias HG, Pauvolid-Corrêa A, Dos Santos CF, Gandini M, Silva AA, Baeta Cavalcanti SM, Artimos de Oliveira S, Artimos de Oliveira Vianna R, Leal de Azeredo E, Grifoni A, Sette A, Weiskopf D, Araújo Cardoso CA, de-Oliveira-Pinto LM. PMID: 33525328; PMCID: PMC7912595.
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Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases. Cell Rep Med. 2021 02 16; 2(2):100204. Tarke A, Sidney J, Kidd CK, Dan JM, Ramirez SI, Yu ED, Mateus J, da Silva Antunes R, Moore E, Rubiro P, Methot N, Phillips E, Mallal S, Frazier A, Rawlings SA, Greenbaum JA, Peters B, Smith DM, Crotty S, Weiskopf D, Grifoni A, Sette A. PMID: 33521695; PMCID: PMC7837622.
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SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Nat Commun. 2021 01 22; 12(1):541. Shaan Lakshmanappa Y, Elizaldi SR, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Verma A, Deere JD, Dutra J, Stone M, Franz S, Sammak RL, Olstad KJ, Rachel Reader J, Ma ZM, Nguyen NK, Watanabe J, Usachenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. PMID: 33483492; PMCID: PMC7822826.
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PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques. Sci Immunol. 2021 01 15; 6(55). Kauffman KD, Sakai S, Lora NE, Namasivayam S, Baker PJ, Kamenyeva O, Foreman TW, Nelson CE, Oliveira-de-Souza D, Vinhaes CL, Yaniv Z, Lindestam Arleham CS, Sette A, Freeman GJ, Moore R, NIAID/DIR Tuberculosis Imaging Program, Sher A, Mayer-Barber KD, Andrade BB, Kabat J, Via LE, Barber DL. PMID: 33452107; PMCID: PMC8300572.
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Differential T cell reactivity to seasonal coronaviruses and SARS-CoV-2 in community and health care workers. medRxiv. 2021 Jan 15. da Silva Antunes R, Pallikkuth S, Williams E, Yu ED, Mateus J, Quiambao L, Wang E, Rawlings SA, Stadlbauer D, Jiang K, Amanat F, Arnold D, Andrews D, Fuego I, Dan JM, Grifoni A, Weiskopf D, Krammer F, Crotty S, Hoffer ME, Pahwa SG, Sette A. PMID: 33469594; PMCID: PMC7814840.
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Corrigendum: T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. Front Neurosci. 2020; 14:641809. Dhanwani R, Pham J, Premlal ALR, Frazier A, Kumar A, Pero ME, Bartolini F, Dutra JR, Marder KS, Peters B, Sulzer D, Sette A, Lindestam Arlehamn CS. PMID: 33519374; PMCID: PMC7841494.
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Adaptive immunity to SARS-CoV-2 and COVID-19. Cell. 2021 02 18; 184(4):861-880. Sette A, Crotty S. PMID: 33497610; PMCID: PMC7803150.
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The TCR repertoire of α-synuclein-specific T cells in Parkinson's disease is surprisingly diverse. Sci Rep. 2021 01 11; 11(1):302. Singhania A, Pham J, Dhanwani R, Frazier A, Rezende Dutra J, Marder KS, Phillips E, Mallal S, Amara AW, Standaert DG, Sulzer D, Peters B, Sette A, Lindestam Arlehamn CS. PMID: 33432042; PMCID: PMC7801678.
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Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science. 2021 02 05; 371(6529). Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S. PMID: 33408181; PMCID: PMC7919858.
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MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies. NPJ Vaccines. 2021 Jan 04; 6(1):4. White AD, Sibley L, Sarfas C, Morrison A, Gullick J, Clark S, Gleeson F, McIntyre A, Arlehamn CL, Sette A, Salguero FJ, Rayner E, Rodriguez E, Puentes E, Laddy D, Williams A, Dennis M, Martin C, Sharpe S. PMID: 33397991; PMCID: PMC7782851.
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Immunological memory to SARS-CoV-2 assessed for up to eight months after infection. bioRxiv. 2020 Dec 18. Dan JM, Mateus J, Kato Y, Hastie KM, Yu ED, Faliti CE, Grifoni A, Ramirez SI, Haupt S, Frazier A, Nakao C, Rayaprolu V, Rawlings SA, Peters B, Krammer F, Simon V, Saphire EO, Smith DM, Weiskopf D, Sette A, Crotty S. PMID: 33442687; PMCID: PMC7805444.
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Comprehensive analysis of T cell immunodominance and immunoprevalence of SARS-CoV-2 epitopes in COVID-19 cases. bioRxiv. 2020 Dec 09. Tarke A, Sidney J, Kidd CK, Dan JM, Ramirez SI, Yu ED, Mateus J, da Silva Antunes R, Moore E, Rubiro P, Methot N, Phillips E, Mallal S, Frazier A, Rawlings SA, Greenbaum JA, Peters B, Smith DM, Crotty S, Weiskopf D, Grifoni A, Sette A. PMID: 33330869; PMCID: PMC7743077.
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Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial. Lancet Respir Med. 2021 04; 9(4):373-386. Day TA, Penn-Nicholson A, Luabeya AKK, Fiore-Gartland A, Du Plessis N, Loxton AG, Vergara J, Rolf TA, Reid TD, Toefy A, Shenje J, Geldenhuys H, Tameris M, Mabwe S, Bilek N, Bekker LG, Diacon A, Walzl G, Ashman J, Frevol A, Sagawa ZK, Lindestam Arlehamn C, Sette A, Reed SG, Coler RN, Scriba TJ, Hatherill M, TBVPX-203 study team. PMID: 33306991.
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In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden. Cytotherapy. 2021 04; 23(4):320-328. Ferrari V, Tarke A, Fields H, Ferrari L, Conley T, Ferrari F, Kosaloglu-Yalçin Z, Sette A, Peters B, McCarthy CL, Bashey A, Tzachanis D, Ball ED, Tanaka TN, Bejar R, Lane TA, Vitiello A. PMID: 33262074.
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Human rhinovirus-specific CD8 T cell responses target conserved and unusual epitopes. FASEB J. 2021 01; 35(1):e21208. Gomez-Perosanz M, Sanchez-Trincado JL, Fernandez-Arquero M, Sidney J, Sette A, Lafuente EM, Reche PA. PMID: 33230881; PMCID: PMC7753581.
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Identification and Characterization of CD4+ T Cell Epitopes after Shingrix Vaccination. J Virol. 2020 11 23; 94(24). Voic H, de Vries RD, Sidney J, Rubiro P, Moore E, Phillips E, Mallal S, Schwan B, Weiskopf D, Sette A, Grifoni A. PMID: 32999027; PMCID: PMC7925171.
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Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19. Front Immunol. 2020; 11:596761. Van Damme KFA, Tavernier S, Van Roy N, De Leeuw E, Declercq J, Bosteels C, Maes B, De Bruyne M, Bogaert D, Bosteels V, Hoste L, Naesens L, Maes P, Grifoni A, Weiskopf D, Sette A, Depuydt P, Van Braeckel E, Haerynck F, Lambrecht BN. PMID: 33329586; PMCID: PMC7714937.
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Identification of Novel Yellow Fever Class II Epitopes in YF-17D Vaccinees. Viruses. 2020 11 12; 12(11). Mateus J, Grifoni A, Voic H, Angelo MA, Phillips E, Mallal S, Sidney J, Sette A, Weiskopf D. PMID: 33198381; PMCID: PMC7697718.
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Comparison of HLA ligand elution data and binding predictions reveals varying prediction performance for the multiple motifs recognized by HLA-DQ2.5. Immunology. 2021 02; 162(2):235-247. Kosaloglu-Yalçin Z, Sidney J, Chronister W, Peters B, Sette A. PMID: 33064841; PMCID: PMC7808151.
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Epitope prediction and identification- adaptive T cell responses in humans. Semin Immunol. 2020 08; 50:101418. Sidney J, Peters B, Sette A. PMID: 33131981; PMCID: PMC7749839.
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HLA tapasin independence: broader peptide repertoire and HIV control. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28232-28238. Bashirova AA, Viard M, Naranbhai V, Grifoni A, Garcia-Beltran W, Akdag M, Yuki Y, Gao X, O'hUigin C, Raghavan M, Wolinsky S, Bream JH, Duggal P, Martinson J, Michael NL, Kirk GD, Buchbinder SP, Haas D, Goedert JJ, Deeks SG, Fellay J, Walker B, Goulder P, Cresswell P, Elliott T, Sette A, Carlson J, Carrington M. PMID: 33097667; PMCID: PMC7668082.
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Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell. 2020 10 29; 183(3):818-834.e13. Wells DK, van Buuren MM, Dang KK, Hubbard-Lucey VM, Sheehan KCF, Campbell KM, Lamb A, Ward JP, Sidney J, Blazquez AB, Rech AJ, Zaretsky JM, Comin-Anduix B, Ng AHC, Chour W, Yu TV, Rizvi H, Chen JM, Manning P, Steiner GM, Doan XC, Tumor Neoantigen Selection Alliance, Merghoub T, Guinney J, Kolom A, Selinsky C, Ribas A, Hellmann MD, Hacohen N, Sette A, Heath JR, Bhardwaj N, Ramsdell F, Schreiber RD, Schumacher TN, Kvistborg P, Defranoux NA. PMID: 33038342; PMCID: PMC7652061.
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Cross-reactive memory T cells and herd immunity to SARS-CoV-2. Nat Rev Immunol. 2020 11; 20(11):709-713. Lipsitch M, Grad YH, Sette A, Crotty S. PMID: 33024281; PMCID: PMC7537578.
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Imbalance of Regulatory and Cytotoxic SARS-CoV-2-Reactive CD4+ T Cells in COVID-19. Cell. 2020 11 25; 183(5):1340-1353.e16. Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Eschweiler S, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. PMID: 33096020; PMCID: PMC7534589.
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Inflammation in Experimental Models of α-Synucleinopathies. Mov Disord. 2021 01; 36(1):37-49. Harms AS, Kordower JH, Sette A, Lindestam Arlehamn CS, Sulzer D, Mach RH. PMID: 33009855; PMCID: PMC8115204.
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Author Correction: Pre-existing immunity to SARS-CoV-2: the knowns and unknowns. Nat Rev Immunol. 2020 Oct; 20(10):644. Sette A, Crotty S. PMID: 32807863; PMCID: PMC7430209.
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Lack of evidence for BCG vaccine protection from severe COVID-19. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25203-25204. Lindestam Arlehamn CS, Sette A, Peters B. PMID: 32994350; PMCID: PMC7568270.
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Lack of evidence supporting a role of IFN-β and TGF-β in differential polarization of Bordetella pertussis specific-T cell responses. Cytokine. 2021 01; 137:155313. da Silva Antunes R, Quiambao LG, Soldevila F, Sutherland A, Peters B, Sette A. PMID: 33002739; PMCID: PMC7726043.
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Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status. Clin Transl Immunology. 2020; 9(9):e1176. Riou C, Du Bruyn E, Ruzive S, Goliath RT, Lindestam Arlehamn CS, Sette A, Sher A, Barber DL, Wilkinson RJ. PMID: 33005414; PMCID: PMC7520805.
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Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. Cell. 2020 11 12; 183(4):996-1012.e19. Rydyznski Moderbacher C, Ramirez SI, Dan JM, Grifoni A, Hastie KM, Weiskopf D, Belanger S, Abbott RK, Kim C, Choi J, Kato Y, Crotty EG, Kim C, Rawlings SA, Mateus J, Tse LPV, Frazier A, Baric R, Peters B, Greenbaum J, Saphire EO, Smith DM, Sette A, Crotty S. PMID: 33010815; PMCID: PMC7494270.
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HLA Class I Binding of Mutant EGFR Peptides in NSCLC Is Associated With Improved Survival. J Thorac Oncol. 2021 01; 16(1):104-112. Dimou A, Grewe P, Sidney J, Sette A, Norman PJ, Doebele RC. PMID: 32927123; PMCID: PMC7797166.
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T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. Front Neurosci. 2020; 14:874. Dhanwani R, Pham J, Premlal ALR, Frazier A, Kumar A, Pero ME, Bartolini F, Dutra JR, Marder KS, Peters B, Sulzer D, Sette A, Lindestam Arlehamn CS. PMID: 32982670; PMCID: PMC7481378.
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COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside. NPJ Parkinsons Dis. 2020; 6:18. Sulzer D, Antonini A, Leta V, Nordvig A, Smeyne RJ, Goldman JE, Al-Dalahmah O, Zecca L, Sette A, Bubacco L, Meucci O, Moro E, Harms AS, Xu Y, Fahn S, Ray Chaudhuri K. PMID: 32885037; PMCID: PMC7441399.
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SARS-CoV-2 infection induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques. Res Sq. 2020 Aug 14. Elizaldi S, Lakshmanappa YS, Roh J, Schmidt B, Carroll T, Weaver K, Smith J, Deere J, Dutra J, Stone M, Franz S, Sammak R, Olstad K, Reader JR, Ma ZM, Nguyen N, Watanabe J, Usachenko J, Immareddy R, Yee J, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley S, Morrison J, Tran N, Simmons G, Busch M, Kozlowsk P, van Rompay K, Miller C, Iyer S. PMID: 32818217; PMCID: PMC7430596.
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Proteome-Wide Zika Virus CD4 T Cell Epitope and HLA Restriction Determination. Immunohorizons. 2020 08 04; 4(8):444-453. Campbell VL, Nguyen L, Snoey E, McClurkan CL, Laing KJ, Dong L, Sette A, Lindestam Arlehamn CS, Altmann DM, Boyton RJ, Roby JA, Gale M, Stone M, Busch MP, Norris PJ, Koelle DM. PMID: 32753403; PMCID: PMC7839664.
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Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. 2020 10 02; 370(6512):89-94. Mateus J, Grifoni A, Tarke A, Sidney J, Ramirez SI, Dan JM, Burger ZC, Rawlings SA, Smith DM, Phillips E, Mallal S, Lammers M, Rubiro P, Quiambao L, Sutherland A, Yu ED, da Silva Antunes R, Greenbaum J, Frazier A, Markmann AJ, Premkumar L, de Silva A, Peters B, Crotty S, Sette A, Weiskopf D. PMID: 32753554; PMCID: PMC7574914.
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Pre-existing immunity to SARS-CoV-2: the knowns and unknowns. Nat Rev Immunol. 2020 08; 20(8):457-458. Sette A, Crotty S. PMID: 32636479; PMCID: PMC7339790.
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A behind-the-scenes tour of the IEDB curation process: an optimized process empirically integrating automation and human curation efforts. Immunology. 2020 10; 161(2):139-147. Salimi N, Edwards L, Foos G, Greenbaum JA, Martini S, Reardon B, Shackelford D, Vita R, Zalman L, Peters B, Sette A. PMID: 32615639; PMCID: PMC7496777.
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Pathogenic Autoimmunity in Atherosclerosis Evolves From Initially Protective Apolipoprotein B100-Reactive CD4+ T-Regulatory Cells. Circulation. 2020 09 29; 142(13):1279-1293. Wolf D, Gerhardt T, Winkels H, Michel NA, Pramod AB, Ghosheh Y, Brunel S, Buscher K, Miller J, McArdle S, Baas L, Kobiyama K, Vassallo M, Ehinger E, Dileepan T, Ali A, Schell M, Mikulski Z, Sidler D, Kimura T, Sheng X, Horstmann H, Hansen S, Mitre LS, Stachon P, Hilgendorf I, Gaddis DE, Hedrick C, Benedict CA, Peters B, Zirlik A, Sette A, Ley K. PMID: 32703007; PMCID: PMC7515473.
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Correction: Quantitative and Qualitative Perturbations of CD8+ MAITs in Healthy Mycobacterium tuberculosis-Infected Individuals. Immunohorizons. 2020 Jul 22; 4(7):442-443. Pomaznoy M, Kuan R, Lindvall M, Burel JG, Seumois G, Vijayanand P, Taplitz R, Gilman RH, Saito M, Lewinsohn DM, Sette A, Peters B, Lindestam Arlehamn CS. PMID: 32699177; PMCID: PMC10202146.
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Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis. Mucosal Immunol. 2021 03; 14(2):491-499. Du Bruyn E, Ruzive S, Lindestam Arlehamn CS, Sette A, Sher A, Barber DL, Wilkinson RJ, Riou C. PMID: 32678272; PMCID: PMC7855386.
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SARS-CoV-2 infection induces germinal center responses with robust stimulation of CD4 T follicular helper cells in rhesus macaques. bioRxiv. 2020 Jul 08. Elizaldi SR, Lakshmanappa YS, Roh JW, Schmidt BA, Carroll TD, Weaver KD, Smith JC, Deere JD, Dutra J, Stone M, Sammak RL, Olstad KJ, Reader JR, Ma ZM, Nguyen NK, Watanabe J, Usachaenko J, Immareddy R, Yee JL, Weiskopf D, Sette A, Hartigan-O'Connor D, McSorley SJ, Morrison JH, Tran NK, Simmons G, Busch MP, Kozlowski PA, Van Rompay KKA, Miller CJ, Iyer SS. PMID: 32676606; PMCID: PMC7359530.
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Single-Cell Transcriptomic Analysis of SARS-CoV-2 Reactive CD4 + T Cells. SSRN. 2020 Jul 07; 3641939. Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. PMID: 32742242; PMCID: PMC7385998.
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Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome. Sci Immunol. 2020 06 26; 5(48). Weiskopf D, Schmitz KS, Raadsen MP, Grifoni A, Okba NMA, Endeman H, van den Akker JPC, Molenkamp R, Koopmans MPG, van Gorp ECM, Haagmans BL, de Swart RL, Sette A, de Vries RD. PMID: 32591408; PMCID: PMC7319493.
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Impact of Cysteine Residues on MHC Binding Predictions and Recognition by Tumor-Reactive T Cells. J Immunol. 2020 07 15; 205(2):539-549. Sachs A, Moore E, Kosaloglu-Yalcin Z, Peters B, Sidney J, Rosenberg SA, Robbins PF, Sette A. PMID: 32571843; PMCID: PMC7413297.
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Persistence of Varicella-Zoster Virus-Specific Plasma Cells in Adult Human Bone Marrow following Childhood Vaccination. J Virol. 2020 06 16; 94(13). Eberhardt CS, Wieland A, Nasti TH, Grifoni A, Wilson E, Schmid DS, Pulendran B, Sette A, Waller EK, Rouphael N, Ahmed R. PMID: 32321817; PMCID: PMC7307153.
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Transient Immune Activation in BCG-Vaccinated Infant Rhesus Macaques Is Not Sufficient to Influence Oral Simian Immunodeficiency Virus Infection. J Infect Dis. 2020 06 16; 222(1):44-53. Wood MP, Wood LF, Templeton M, Fisher B, Lippy A, Jones CI, Lindestam Arlehamn CS, Sette A, Fuller JT, Murapa P, Jaspan HB, Fuller DH, Sodora DL. PMID: 31605528; PMCID: PMC7457186.
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Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4 + T cells. bioRxiv. 2020 Jun 13. Meckiff BJ, Ramírez-Suástegui C, Fajardo V, Chee SJ, Kusnadi A, Simon H, Grifoni A, Pelosi E, Weiskopf D, Sette A, Ay F, Seumois G, Ottensmeier CH, Vijayanand P. PMID: 32587963; PMCID: PMC7310619.
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Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma. Sci Immunol. 2020 06 12; 5(48). Seumois G, Ramírez-Suástegui C, Schmiedel BJ, Liang S, Peters B, Sette A, Vijayanand P. PMID: 32532832; PMCID: PMC7372639.
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The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients. Sci Immunol. 2020 06 11; 5(48). Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Rouphael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. PMID: 32527802; PMCID: PMC7292505.
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Quantitative and Qualitative Perturbations of CD8+ MAITs in Healthy Mycobacterium tuberculosis-Infected Individuals. Immunohorizons. 2020 06 04; 4(6):292-307. Pomaznoy M, Kuan R, Lindvall M, Burel JG, Seumois G, Vijayanand P, Taplitz R, Gilman RH, Saito M, Lewinsohn DM, Sette A, Peters B, Lindestam Arlehamn CS. PMID: 32499216; PMCID: PMC7543048.
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Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system. PLoS Comput Biol. 2020 05; 16(5):e1007757. Paul S, Croft NP, Purcell AW, Tscharke DC, Sette A, Nielsen M, Peters B. PMID: 32453790; PMCID: PMC7274474.
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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell. 2020 06 25; 181(7):1489-1501.e15. Grifoni A, Weiskopf D, Ramirez SI, Mateus J, Dan JM, Moderbacher CR, Rawlings SA, Sutherland A, Premkumar L, Jadi RS, Marrama D, de Silva AM, Frazier A, Carlin AF, Greenbaum JA, Peters B, Krammer F, Smith DM, Crotty S, Sette A. PMID: 32473127; PMCID: PMC7237901.
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The Challenge of Distinguishing Cell-Cell Complexes from Singlet Cells in Non-Imaging Flow Cytometry and Single-Cell Sorting. Cytometry A. 2020 11; 97(11):1127-1135. Burel JG, Pomaznoy M, Lindestam Arlehamn CS, Seumois G, Vijayanand P, Sette A, Peters B. PMID: 32400942; PMCID: PMC7666012.
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The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies. medRxiv. 2020 May 10. Premkumar L, Segovia-Chumbez B, Jadi R, Martinez DR, Raut R, Markmann A, Cornaby C, Bartelt L, Weiss S, Park Y, Edwards CE, Weimer E, Scherer EM, Roupael N, Edupuganti S, Weiskopf D, Tse LV, Hou YJ, Margolis D, Sette A, Collins MH, Schmitz J, Baric RS, de Silva AM. PMID: 32511572; PMCID: PMC7274253.
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T Cell Responses Induced by Attenuated Flavivirus Vaccination Are Specific and Show Limited Cross-Reactivity with Other Flavivirus Species. J Virol. 2020 05 04; 94(10). Grifoni A, Voic H, Dhanda SK, Kidd CK, Brien JD, Buus S, Stryhn A, Durbin AP, Whitehead S, Diehl SA, De Silva AD, Balmaseda A, Harris E, Weiskopf D, Sette A. PMID: 32132233; PMCID: PMC7199411.
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α-Synuclein-specific T cell reactivity is associated with preclinical and early Parkinson's disease. Nat Commun. 2020 04 20; 11(1):1875. Lindestam Arlehamn CS, Dhanwani R, Pham J, Kuan R, Frazier A, Rezende Dutra J, Phillips E, Mallal S, Roederer M, Marder KS, Amara AW, Standaert DG, Goldman JG, Litvan I, Peters B, Sulzer D, Sette A. PMID: 32313102; PMCID: PMC7171193.
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Development and Validation of a Bordetella pertussis Whole-Genome Screening Strategy. J Immunol Res. 2020; 2020:8202067. da Silva Antunes R, Quiambao LG, Sutherland A, Soldevila F, Dhanda SK, Armstrong SK, Brickman TJ, Merkel T, Peters B, Sette A. PMID: 32322598; PMCID: PMC7154976.
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Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination. Sci Adv. 2020 04; 6(14):eaaw7713. Si Y, Zhao F, Beesetty P, Weiskopf D, Li Z, Tian Q, Alegre ML, Sette A, Chong AS, Montgomery CP. PMID: 32270029; PMCID: PMC7112766.
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Characterization of Proinsulin T Cell Epitopes Restricted by Type 1 Diabetes-Associated HLA Class II Molecules. J Immunol. 2020 05 01; 204(9):2349-2359. Ihantola EL, Ilmonen H, Kailaanmäki A, Rytkönen-Nissinen M, Azam A, Maillère B, Lindestam Arlehamn CS, Sette A, Motwani K, Seay HR, Brusko TM, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T. PMID: 32229538; PMCID: PMC9022012.
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Rapid Induction and Maintenance of Virus-Specific CD8+ TEMRA and CD4+ TEM Cells Following Protective Vaccination Against Dengue Virus Challenge in Humans. Front Immunol. 2020; 11:479. Graham N, Eisenhauer P, Diehl SA, Pierce KK, Whitehead SS, Durbin AP, Kirkpatrick BD, Sette A, Weiskopf D, Boyson JE, Botten JW. PMID: 32265929; PMCID: PMC7105617.
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Safety and immunogenicity of the tetravalent, live-attenuated dengue vaccine Butantan-DV in adults in Brazil: a two-step, double-blind, randomised placebo-controlled phase 2 trial. Lancet Infect Dis. 2020 07; 20(7):839-850. Kallas EG, Precioso AR, Palacios R, Thomé B, Braga PE, Vanni T, Campos LMA, Ferrari L, Mondini G, da Graça Salomão M, da Silva A, Espinola HM, do Prado Santos J, Santos CLS, Timenetsky MDCST, Miraglia JL, Gallina NMF, Weiskopf D, Sette A, Goulart R, Salles RT, Maestri A, Sallum AME, Farhat SCL, Sakita NK, Ferreira JCOA, Silveira CGT, Costa PR, Raw I, Whitehead SS, Durbin AP, Kalil J. PMID: 32220283.
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A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2. Cell Host Microbe. 2020 04 08; 27(4):671-680.e2. Grifoni A, Sidney J, Zhang Y, Scheuermann RH, Peters B, Sette A. PMID: 32183941; PMCID: PMC7142693.
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Howard Grey 1932-2019. Nat Immunol. 2020 03; 21(3):242. Sette A. PMID: 32015542; PMCID: PMC7223305.
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Candidate Targets for Immune Responses to 2019-Novel Coronavirus (nCoV): Sequence Homology- and Bioinformatic-Based Predictions. SSRN. 2020 Feb 25; 3541361. Grifoni A, Sidney J, Zhang Y, Scheuermann RH, Peters B, Sette A. PMID: 32714104; PMCID: PMC7366807.
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T Cell Epitope Predictions. Annu Rev Immunol. 2020 04 26; 38:123-145. Peters B, Nielsen M, Sette A. PMID: 32045313; PMCID: PMC10878398.
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Major Histocompatibility Complex Binding, Eluted Ligands, and Immunogenicity: Benchmark Testing and Predictions. Front Immunol. 2019; 10:3151. Paul S, Grifoni A, Peters B, Sette A. PMID: 32117208; PMCID: PMC7012937.
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Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria. Front Immunol. 2019; 10:3037. Heide J, Wildner NH, Ackermann C, Wittner M, Marget M, Sette A, Sidney J, Jacobs T, Schulze Zur Wiesch J. PMID: 32038611; PMCID: PMC6993587.
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Transcriptomic immune profiles of human flavivirus-specific T-cell responses. Immunology. 2020 05; 160(1):3-9. Grifoni A, Tian Y, Sette A, Weiskopf D. PMID: 31778581; PMCID: PMC7160650.
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Epitope-specific airway-resident CD4+ T cell dynamics during experimental human RSV infection. J Clin Invest. 2020 01 02; 130(1):523-538. Guvenel A, Jozwik A, Ascough S, Ung SK, Paterson S, Kalyan M, Gardener Z, Bergstrom E, Kar S, Habibi MS, Paras A, Zhu J, Park M, Dhariwal J, Almond M, Wong EH, Sykes A, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C. PMID: 31815739; PMCID: PMC6934186.
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A structured model for immune exposures. Database (Oxford). 2020 01 01; 2020. Vita R, Overton JA, Dunn P, Cheung KH, Kleinstein SH, Sette A, Peters B. PMID: 32283555; PMCID: PMC7153954.
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Molecular Signatures of Dengue Virus-Specific IL-10/IFN-γ Co-producing CD4 T Cells and Their Association with Dengue Disease. Cell Rep. 2019 12 24; 29(13):4482-4495.e4. Tian Y, Seumois G, De-Oliveira-Pinto LM, Mateus J, Herrera-de la Mata S, Kim C, Hinz D, Goonawardhana NDS, de Silva AD, Premawansa S, Premawansa G, Wijewickrama A, Balmaseda A, Grifoni A, Vijayanand P, Harris E, Peters B, Sette A, Weiskopf D. PMID: 31875555; PMCID: PMC6942518.
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Evolution of the innate and adaptive immune response in women with acute Zika virus infection. Nat Microbiol. 2020 01; 5(1):76-83. Tonnerre P, Melgaço JG, Torres-Cornejo A, Pinto MA, Yue C, Blümel J, de Sousa PSF, de Mello VDM, Moran J, de Filippis AMB, Wolski D, Grifoni A, Sette A, Barouch DH, Hoogeveen RC, Baylis SA, Lauer GM, Lewis-Ximenez LL. PMID: 31792427; PMCID: PMC6938397.
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The Immune Epitope Database and Analysis Resource Program 2003-2018: reflections and outlook. Immunogenetics. 2020 02; 72(1-2):57-76. Martini S, Nielsen M, Peters B, Sette A. PMID: 31761977; PMCID: PMC6970984.
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The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases. Mol Cell Proteomics. 2020 01; 19(1):31-49. Vizcaíno JA, Kubiniok P, Kovalchik KA, Ma Q, Duquette JD, Mongrain I, Deutsch EW, Peters B, Sette A, Sirois I, Caron E. PMID: 31744855; PMCID: PMC6944237.
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An in silico-in vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients. Front Immunol. 2019; 10:2572. Mishto M, Mansurkhodzhaev A, Ying G, Bitra A, Cordfunke RA, Henze S, Paul D, Sidney J, Urlaub H, Neefjes J, Sette A, Zajonc DM, Liepe J. PMID: 31803176; PMCID: PMC6872521.
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Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice. Mucosal Immunol. 2020 01; 13(1):140-148. Patankar YR, Sutiwisesak R, Boyce S, Lai R, Lindestam Arlehamn CS, Sette A, Behar SM. PMID: 31636345; PMCID: PMC7161428.
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Benchmark datasets of immune receptor-epitope structural complexes. BMC Bioinformatics. 2019 Oct 10; 20(1):490. Mahajan S, Yan Z, Jespersen MC, Jensen KK, Marcatili P, Nielsen M, Sette A, Peters B. PMID: 31601176; PMCID: PMC6785892.
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Anti-HIV potency of T-cell responses elicited by dendritic cell therapeutic vaccination. PLoS Pathog. 2019 09; 15(9):e1008011. Surenaud M, Montes M, Lindestam Arlehamn CS, Sette A, Banchereau J, Palucka K, Lelièvre JD, Lacabaratz C, Lévy Y. PMID: 31498845; PMCID: PMC6733439.
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Human T Cell Response to Dengue Virus Infection. Front Immunol. 2019; 10:2125. Tian Y, Grifoni A, Sette A, Weiskopf D. PMID: 31552052; PMCID: PMC6737489.
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Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis. J Infect Dis. 2019 08 30; 220(7):1091-1098. Shah JA, Lindestam Arlehamn CS, Horne DJ, Sette A, Hawn TR. PMID: 31165861; PMCID: PMC6736075.
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A survey of known immune epitopes in the enteroviruses strains associated with acute flaccid myelitis. Hum Immunol. 2019 Nov; 80(11):923-929. Grifoni A, Mahajan S, Sidney J, Martini S, Scheuermann RH, Peters B, Sette A. PMID: 31451291; PMCID: PMC6876747.
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Roles for the adaptive immune system in Parkinson's and Alzheimer's diseases. Curr Opin Immunol. 2019 08; 59:115-120. Lindestam Arlehamn CS, Garretti F, Sulzer D, Sette A. PMID: 31430650; PMCID: PMC6774843.
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Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids. J Immunol. 2019 09 15; 203(6):1619-1628. Cheloha RW, Woodham AW, Bousbaine D, Wang T, Liu S, Sidney J, Sette A, Gellman SH, Ploegh HL. PMID: 31391235; PMCID: PMC6736755.
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A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer. Cytometry A. 2019 09; 95(9):1019-1030. Lee BH, Kelly G, Bradford S, Davila M, Guo XV, Amir ED, Thrash EM, Solga MD, Lannigan J, Sellers B, Candia J, Tsang J, Montgomery RR, Tamaki SJ, Sigdel TK, Sarwal MM, Lanier LL, Tian Y, Kim C, Hinz D, Peters B, Sette A, Rahman AH. PMID: 31364278; PMCID: PMC6750971.
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Characterization of Magnitude and Antigen Specificity of HLA-DP, DQ, and DRB3/4/5 Restricted DENV-Specific CD4+ T Cell Responses. Front Immunol. 2019; 10:1568. Grifoni A, Moore E, Voic H, Sidney J, Phillips E, Jadi R, Mallal S, De Silva AD, De Silva AM, Peters B, Weiskopf D, Sette A. PMID: 31333679; PMCID: PMC6624677.
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IEDB-AR: immune epitope database-analysis resource in 2019. Nucleic Acids Res. 2019 07 02; 47(W1):W502-W506. Dhanda SK, Mahajan S, Paul S, Yan Z, Kim H, Jespersen MC, Jurtz V, Andreatta M, Greenbaum JA, Marcatili P, Sette A, Nielsen M, Peters B. PMID: 31114900; PMCID: PMC6602498.
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Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses. Nat Commun. 2019 06 28; 10(1):2846. Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL. PMID: 31253788; PMCID: PMC6599079.
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Circulating T cell-monocyte complexes are markers of immune perturbations. Elife. 2019 06 25; 8. Burel JG, Pomaznoy M, Lindestam Arlehamn CS, Weiskopf D, da Silva Antunes R, Jung Y, Babor M, Schulten V, Seumois G, Greenbaum JA, Premawansa S, Premawansa G, Wijewickrama A, Vidanagama D, Gunasena B, Tippalagama R, deSilva AD, Gilman RH, Saito M, Taplitz R, Ley K, Vijayanand P, Sette A, Peters B. PMID: 31237234; PMCID: PMC6592685.
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The association of allergic sensitization patterns in early childhood with disease manifestations and immunological reactivity at 10 years of age. Clin Exp Allergy. 2019 08; 49(8):1087-1094. Schulten V, Frazier A, Calatroni A, Kattan M, Bacharier LB, O'Connor GT, Sandel MT, Wood RA, Wheatley LM, Togias A, Visness CM, Dresen A, Gern JE, Sette A. PMID: 31046157; PMCID: PMC6896992.
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Longitudinal Analysis of the Human B Cell Response to Ebola Virus Infection. Cell. 2019 05 30; 177(6):1566-1582.e17. Davis CW, Jackson KJL, McElroy AK, Halfmann P, Huang J, Chennareddy C, Piper AE, Leung Y, Albariño CG, Crozier I, Ellebedy AH, Sidney J, Sette A, Yu T, Nielsen SCA, Goff AJ, Spiropoulou CF, Saphire EO, Cavet G, Kawaoka Y, Mehta AK, Glass PJ, Boyd SD, Ahmed R. PMID: 31104840; PMCID: PMC6908968.
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Widespread Tau-Specific CD4 T Cell Reactivity in the General Population. J Immunol. 2019 07 01; 203(1):84-92. Lindestam Arlehamn CS, Pham J, Alcalay RN, Frazier A, Shorr E, Carpenter C, Sidney J, Dhanwani R, Agin-Liebes J, Garretti F, Amara AW, Standaert DG, Phillips EJ, Mallal SA, Peters B, Sulzer D, Sette A. PMID: 31085590; PMCID: PMC6581570.
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Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses. Eur J Immunol. 2019 08; 49(8):1167-1185. Becerra-Artiles A, Cruz J, Leszyk JD, Sidney J, Sette A, Shaffer SA, Stern LJ. PMID: 31020640.
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Characterization and epitope identification of the T cell response in non-allergic individuals exposed to mouse allergen. World Allergy Organ J. 2019; 12(4):100026. Grifoni A, da Silva Antunes R, Westernberg L, Pham J, Birrueta G, Peters B, Sette A, Schulten V. PMID: 31044023; PMCID: PMC6479169.
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Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes. Front Immunol. 2019; 10:397. Heide J, Vaughan KC, Sette A, Jacobs T, Schulze Zur Wiesch J. PMID: 30949162; PMCID: PMC6438266.
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Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles. J Clin Invest. 2019 03 18; 129(4):1727-1741. Tian Y, Babor M, Lane J, Seumois G, Liang S, Goonawardhana NDS, De Silva AD, Phillips EJ, Mallal SA, da Silva Antunes R, Grifoni A, Vijayanand P, Weiskopf D, Peters B, Sette A. PMID: 30882366; PMCID: PMC6436856.
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New epitopes in ovalbumin provide insights for cancer neoepitopes. JCI Insight. 2019 03 14; 5. Karandikar SH, Sidney J, Sette A, Selby MJ, Korman AJ, Srivastava PK. PMID: 30869653; PMCID: PMC6538383.
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Variability in German Cockroach Extract Composition Greatly Impacts T Cell Potency in Cockroach-Allergic Donors. Front Immunol. 2019; 10:313. Birrueta G, Frazier A, Pomés A, Glesner J, Filep S, Schal C, Jeong KY, McMurtrey C, Vander Schans T, Hildebrand WH, Busse P, Beigelman A, Bacharier LB, Peters B, Sette A, Schulten V. PMID: 30891032; PMCID: PMC6413722.
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Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells. Front Immunol. 2019; 10:303. Garretti F, Agalliu D, Lindestam Arlehamn CS, Sette A, Sulzer D. PMID: 30858851; PMCID: PMC6397885.
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Host Transcriptomics as a Tool to Identify Diagnostic and Mechanistic Immune Signatures of Tuberculosis. Front Immunol. 2019; 10:221. Burel JG, Babor M, Pomaznoy M, Lindestam Arlehamn CS, Khan N, Sette A, Peters B. PMID: 30837989; PMCID: PMC6389658.
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Counter-regulation of regulatory T cells by autoreactive CD8+ T cells in rheumatoid arthritis. J Autoimmun. 2019 05; 99:81-97. Cammarata I, Martire C, Citro A, Raimondo D, Fruci D, Melaiu O, D'Oria V, Carone C, Peruzzi G, Cerboni C, Santoni A, Sidney J, Sette A, Paroli M, Caccavale R, Milanetti E, Riminucci M, Timperi E, Piconese S, Manzo A, Montecucco C, Scrivo R, Valesini G, Cariani E, Barnaba V. PMID: 30777378.
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Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells. Sci Transl Med. 2019 02 06; 11(478). Dan JM, Havenar-Daughton C, Kendric K, Al-Kolla R, Kaushik K, Rosales SL, Anderson EL, LaRock CN, Vijayanand P, Seumois G, Layfield D, Cutress RI, Ottensmeier CH, Lindestam Arlehamn CS, Sette A, Nizet V, Bothwell M, Brigger M, Crotty S. PMID: 30728285; PMCID: PMC6561727.
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Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci U S A. 2019 02 19; 116(8):3112-3117. Croft NP, Smith SA, Pickering J, Sidney J, Peters B, Faridi P, Witney MJ, Sebastian P, Flesch IEA, Heading SL, Sette A, La Gruta NL, Purcell AW, Tscharke DC. PMID: 30718433; PMCID: PMC6386720.
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Poor Antigen Processing of Poxvirus Particles Limits CD4+ T Cell Recognition and Impacts Immunogenicity of the Inactivated Vaccine. J Immunol. 2019 03 01; 202(5):1340-1349. Forsyth KS, DeHaven B, Mendonca M, Paul S, Sette A, Eisenlohr LC. PMID: 30700590; PMCID: PMC6394857.
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Detection of a Broad Range of Low-Level Major Histocompatibility Complex Class II-Restricted, Hepatitis Delta Virus (HDV)-Specific T-Cell Responses Regardless of Clinical Status. J Infect Dis. 2019 01 29; 219(4):568-577. Landahl J, Bockmann JH, Scheurich C, Ackermann C, Matzat V, Heide J, Nuurei T, D'Antonio G, von Felden J, Sette A, Peine S, Lohse AW, Luetgehetmann M, Marget M, Sidney J, Schulze Zur Wiesch J. PMID: 30247653.
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Hepatitis D Virus-Specific CD8+ T Cells Have a Memory-Like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection. Gastroenterology. 2019 05; 156(6):1805-1819.e9. Kefalakes H, Koh C, Sidney J, Amanakis G, Sette A, Heller T, Rehermann B. PMID: 30664876; PMCID: PMC7367679.
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The Immune Epitope Database (IEDB): 2018 update. Nucleic Acids Res. 2019 01 08; 47(D1):D339-D343. Vita R, Mahajan S, Overton JA, Dhanda SK, Martini S, Cantrell JR, Wheeler DK, Sette A, Peters B. PMID: 30357391; PMCID: PMC6324067.
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ZikaPLAN: addressing the knowledge gaps and working towards a research preparedness network in the Americas. Glob Health Action. 2019; 12(1):1666566. Wilder-Smith A, Preet R, Brickley EB, Ximenes RAA, Miranda-Filho DB, Turchi Martelli CM, Araújo TVB, Montarroyos UR, Moreira ME, Turchi MD, Solomon T, Jacobs BC, Villamizar CP, Osorio L, de Filipps AMB, Neyts J, Kaptein S, Huits R, Ariën KK, Willison HJ, Edgar JM, Barnett SC, Peeling R, Boeras D, Guzman MG, de Silva AM, Falconar AK, Romero-Vivas C, Gaunt MW, Sette A, Weiskopf D, Lambrechts L, Dolk H, Morris JK, Orioli IM, O'Reilly KM, Yakob L, Rocklöv J, Soares C, Ferreira MLB, Franca RFO, Precioso AR, Logan J, Lang T, Jamieson N, Massad E. PMID: 31640505; PMCID: PMC6818126.
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Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23. Sci Immunol. 2018 12 21; 3(30). Martínez-Barricarte R, Markle JG, Ma CS, Deenick EK, Ramírez-Alejo N, Mele F, Latorre D, Mahdaviani SA, Aytekin C, Mansouri D, Bryant VL, Jabot-Hanin F, Deswarte C, Nieto-Patlán A, Surace L, Kerner G, Itan Y, Jovic S, Avery DT, Wong N, Rao G, Patin E, Okada S, Bigio B, Boisson B, Rapaport F, Seeleuthner Y, Schmidt M, Ikinciogullari A, Dogu F, Tanir G, Tabarsi P, Bloursaz MR, Joseph JK, Heer A, Kong XF, Migaud M, Lazarov T, Geissmann F, Fleckenstein B, Arlehamn CL, Sette A, Puel A, Emile JF, van de Vosse E, Quintana-Murci L, Di Santo JP, Abel L, Boisson-Dupuis S, Bustamante J, Tangye SG, Sallusto F, Casanova JL. PMID: 30578351; PMCID: PMC6380365.
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A Review on T Cell Epitopes Identified Using Prediction and Cell-Mediated Immune Models for Mycobacterium tuberculosis and Bordetella pertussis. Front Immunol. 2018; 9:2778. Tian Y, da Silva Antunes R, Sidney J, Lindestam Arlehamn CS, Grifoni A, Dhanda SK, Paul S, Peters B, Weiskopf D, Sette A. PMID: 30555469; PMCID: PMC6281829.
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Epitope Specific Antibodies and T Cell Receptors in the Immune Epitope Database. Front Immunol. 2018; 9:2688. Mahajan S, Vita R, Shackelford D, Lane J, Schulten V, Zarebski L, Jespersen MC, Marcatili P, Nielsen M, Sette A, Peters B. PMID: 30515166; PMCID: PMC6255941.
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Limited Pulmonary Mucosal-Associated Invariant T Cell Accumulation and Activation during Mycobacterium tuberculosis Infection in Rhesus Macaques. Infect Immun. 2018 12; 86(12). Kauffman KD, Sallin MA, Hoft SG, Sakai S, Moore R, Wilder-Kofie T, Moore IN, Sette A, Arlehamn CSL, Barber DL. PMID: 30201702; PMCID: PMC6246904.
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Footprints of antigen processing boost MHC class II natural ligand predictions. Genome Med. 2018 11 16; 10(1):84. Barra C, Alvarez B, Paul S, Sette A, Peters B, Andreatta M, Buus S, Nielsen M. PMID: 30446001; PMCID: PMC6240193.
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Investigation of Outbreak-Specific Nonsynonymous Mutations on Ebolavirus GP in the Context of Known Immune Reactivity. J Immunol Res. 2018; 2018:1846207. Vaughan K, Xu X, Peters B, Sette A. PMID: 30581874; PMCID: PMC6276448.
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ImmunomeBrowser: a tool to aggregate and visualize complex and heterogeneous epitopes in reference proteins. Bioinformatics. 2018 11 15; 34(22):3931-3933. Dhanda SK, Vita R, Ha B, Grifoni A, Peters B, Sette A. PMID: 29878047; PMCID: PMC6223373.
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Mapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells. Cancer Immunol Res. 2019 01; 7(1):62-76. Liepe J, Sidney J, Lorenz FKM, Sette A, Mishto M. PMID: 30425108; PMCID: PMC12032831.
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Cutting Edge: Transcriptional Profiling Reveals Multifunctional and Cytotoxic Antiviral Responses of Zika Virus-Specific CD8+ T Cells. J Immunol. 2018 12 15; 201(12):3487-3491. Grifoni A, Costa-Ramos P, Pham J, Tian Y, Rosales SL, Seumois G, Sidney J, de Silva AD, Premkumar L, Collins MH, Stone M, Norris PJ, Romero CME, Durbin A, Ricciardi MJ, Ledgerwood JE, de Silva AM, Busch M, Peters B, Vijayanand P, Harris E, Falconar AK, Kallas E, Weiskopf D, Sette A. PMID: 30413672; PMCID: PMC6287102.
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Peanut-specific T cell responses in patients with different clinical reactivity. PLoS One. 2018; 13(10):e0204620. Birrueta G, Tripple V, Pham J, Manohar M, James EA, Kwok WW, Nadeau KC, Sette A, Peters B, Schulten V. PMID: 30304054; PMCID: PMC6179248.
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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA. Hum Immunol. 2018 Dec; 79(12):821-822. Moore E, Grifoni A, Weiskopf D, Schulten V, Arlehamn CSL, Angelo M, Pham J, Leary S, Sidney J, Broide D, Frazier A, Phillips E, Mallal S, Mack SJ, Sette A. PMID: 30278218; PMCID: PMC6537871.
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Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B. Circulation. 2018 09 11; 138(11):1130-1143. Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K. PMID: 29588316; PMCID: PMC6160361.
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Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression. Nat Microbiol. 2018 11; 3(11):1198-1205. Sallin MA, Kauffman KD, Riou C, Du Bruyn E, Foreman TW, Sakai S, Hoft SG, Myers TG, Gardina PJ, Sher A, Moore R, Wilder-Kofie T, Moore IN, Sette A, Lindestam Arlehamn CS, Wilkinson RJ, Barber DL. PMID: 30202016.
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Allergen content in German cockroach extracts and sensitization profiles to a new expanded set of cockroach allergens determine in vitro extract potency for IgE reactivity. J Allergy Clin Immunol. 2019 04; 143(4):1474-1481.e8. Glesner J, Filep S, Vailes LD, Wünschmann S, Chapman MD, Birrueta G, Frazier A, Jeong KY, Schal C, Bacharier L, Beigelman A, Busse P, Schulten V, Sette A, Pomés A. PMID: 30170124; PMCID: PMC6395535.
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Predicting T cell recognition of MHC class I restricted neoepitopes. Oncoimmunology. 2018; 7(11):e1492508. Kosaloglu-Yalçin Z, Lanka M, Frentzen A, Logandha Ramamoorthy Premlal A, Sidney J, Vaughan K, Greenbaum J, Robbins P, Gartner J, Sette A, Peters B. PMID: 30377561; PMCID: PMC6204999.
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Identification of Mycobacterial Ribosomal Proteins as Targets for CD4+ T Cells That Enhance Protective Immunity in Tuberculosis. Infect Immun. 2018 09; 86(9). Kennedy SC, Johnson AJ, Bharrhan S, Lindestam Arlehamn CS, Xu J, Garforth SJ, Chan J, Jacobs WR, Sette A, Almo SC, Porcelli SA. PMID: 29891545; PMCID: PMC6105890.
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Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency. Nat Immunol. 2018 09; 19(9):973-985. Kong XF, Martinez-Barricarte R, Kennedy J, Mele F, Lazarov T, Deenick EK, Ma CS, Breton G, Lucero KB, Langlais D, Bousfiha A, Aytekin C, Markle J, Trouillet C, Jabot-Hanin F, Arlehamn CSL, Rao G, Picard C, Lasseau T, Latorre D, Hambleton S, Deswarte C, Itan Y, Abarca K, Moraes-Vasconcelos D, Ailal F, Ikinciogullari A, Dogu F, Benhsaien I, Sette A, Abel L, Boisson-Dupuis S, Schröder B, Nussenzweig MC, Liu K, Geissmann F, Tangye SG, Gros P, Sallusto F, Bustamante J, Casanova JL. PMID: 30127434; PMCID: PMC6130844.
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Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands. Front Immunol. 2018; 9:1795. Paul S, Karosiene E, Dhanda SK, Jurtz V, Edwards L, Nielsen M, Sette A, Peters B. PMID: 30127785; PMCID: PMC6087742.
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Development of a novel clustering tool for linear peptide sequences. Immunology. 2018 11; 155(3):331-345. Dhanda SK, Vaughan K, Schulten V, Grifoni A, Weiskopf D, Sidney J, Peters B, Sette A. PMID: 30014462; PMCID: PMC6187223.
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Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters. J Clin Invest. 2018 08 31; 128(9):3853-3865. da Silva Antunes R, Babor M, Carpenter C, Khalil N, Cortese M, Mentzer AJ, Seumois G, Petro CD, Purcell LA, Vijayanand P, Crotty S, Pulendran B, Peters B, Sette A. PMID: 29920186; PMCID: PMC6118631.
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Predicting HLA CD4 Immunogenicity in Human Populations. Front Immunol. 2018; 9:1369. Dhanda SK, Karosiene E, Edwards L, Grifoni A, Paul S, Andreatta M, Weiskopf D, Sidney J, Nielsen M, Peters B, Sette A. PMID: 29963059; PMCID: PMC6010533.
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Minimal Information About an Immuno-Peptidomics Experiment (MIAIPE). Proteomics. 2018 06; 18(12):e1800110. Lill JR, van Veelen PA, Tenzer S, Admon A, Caron E, Elias JE, Heck AJR, Marcilla M, Marino F, Müller M, Peters B, Purcell A, Sette A, Sturm T, Ternette N, Vizcaíno JA, Bassani-Sternberg M. PMID: 29791771; PMCID: PMC6033177.
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The effect of acylation with fatty acids and other modifications on HLA class II:peptide binding and T cell stimulation for three model peptides. PLoS One. 2018; 13(5):e0197407. Schultz HS, Østergaard S, Sidney J, Lamberth K, Sette A. PMID: 29758051; PMCID: PMC5951580.
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Microbiota epitope similarity either dampens or enhances the immunogenicity of disease-associated antigenic epitopes. PLoS One. 2018; 13(5):e0196551. Carrasco Pro S, Lindestam Arlehamn CS, Dhanda SK, Carpenter C, Lindvall M, Faruqi AA, Santee CA, Renz H, Sidney J, Peters B, Sette A. PMID: 29734356; PMCID: PMC5937769.
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Urinary Peptides As a Novel Source of T Cell Allergen Epitopes. Front Immunol. 2018; 9:886. da Silva Antunes R, Pham J, McMurtrey C, Hildebrand WH, Phillips E, Mallal S, Sidney J, Busse P, Peters B, Schulten V, Sette A. PMID: 29755469; PMCID: PMC5932195.
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DAFi: A directed recursive data filtering and clustering approach for improving and interpreting data clustering identification of cell populations from polychromatic flow cytometry data. Cytometry A. 2018 06; 93(6):597-610. Lee AJ, Chang I, Burel JG, Lindestam Arlehamn CS, Mandava A, Weiskopf D, Peters B, Sette A, Scheuermann RH, Qian Y. PMID: 29665244; PMCID: PMC6030426.
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Transcriptomic Analysis of CD4+ T Cells Reveals Novel Immune Signatures of Latent Tuberculosis. J Immunol. 2018 05 01; 200(9):3283-3290. Burel JG, Lindestam Arlehamn CS, Khan N, Seumois G, Greenbaum JA, Taplitz R, Gilman RH, Saito M, Vijayanand P, Sette A, Peters B. PMID: 29602771; PMCID: PMC5991485.
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Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications. BMC Immunol. 2018 03 21; 19(1):12. Sidney J, Vela JL, Friedrich D, Kolla R, von Herrath M, Wesley JD, Sette A. PMID: 29562882; PMCID: PMC5863483.
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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 159 individuals from the Worcester region of the Western Cape province of South Africa. Hum Immunol. 2018 Mar; 79(3):143-144. Grifoni A, Sidney J, Carpenter C, Phillips E, Mallal S, Scriba TJ, Sette A, Lindestam Arlehamn CS. PMID: 29398200.
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Development of Envelope Protein Antigens To Serologically Differentiate Zika Virus Infection from Dengue Virus Infection. J Clin Microbiol. 2018 03; 56(3). Premkumar L, Collins M, Graham S, Liou GA, Lopez CA, Jadi R, Balmaseda A, Brackbill JA, Dietze R, Camacho E, De Silva AD, Giuberti C, Dos Reis HL, Singh T, Heimsath H, Weiskopf D, Sette A, Osorio JE, Permar SR, Miley MJ, Lazear HM, Harris E, de Silva AM. PMID: 29263206; PMCID: PMC5824056.
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Correction: Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. PLoS One. 2018; 13(2):e0193382. da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS. PMID: 29462188; PMCID: PMC5819815.
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Allergen and Epitope Targets of Mouse-Specific T Cell Responses in Allergy and Asthma. Front Immunol. 2018; 9:235. Schulten V, Westernberg L, Birrueta G, Sidney J, Paul S, Busse P, Peters B, Sette A. PMID: 29487600; PMCID: PMC5816932.
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Improved methods for predicting peptide binding affinity to MHC class II molecules. Immunology. 2018 07; 154(3):394-406. Jensen KK, Andreatta M, Marcatili P, Buus S, Greenbaum JA, Yan Z, Sette A, Peters B, Nielsen M. PMID: 29315598; PMCID: PMC6002223.
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Precursors of human CD4+ cytotoxic T lymphocytes identified by single-cell transcriptome analysis. Sci Immunol. 2018 01 19; 3(19). Patil VS, Madrigal A, Schmiedel BJ, Clarke J, O'Rourke P, de Silva AD, Harris E, Peters B, Seumois G, Weiskopf D, Sette A, Vijayanand P. PMID: 29352091; PMCID: PMC5931334.
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The SysteMHC Atlas project. Nucleic Acids Res. 2018 01 04; 46(D1):D1237-D1247. Shao W, Pedrioli PGA, Wolski W, Scurtescu C, Schmid E, Vizcaíno JA, Courcelles M, Schuster H, Kowalewski D, Marino F, Arlehamn CSL, Vaughan K, Peters B, Sette A, Ottenhoff THM, Meijgaarden KE, Nieuwenhuizen N, Kaufmann SHE, Schlapbach R, Castle JC, Nesvizhskii AI, Nielsen M, Deutsch EW, Campbell DS, Moritz RL, Zubarev RA, Ytterberg AJ, Purcell AW, Marcilla M, Paradela A, Wang Q, Costello CE, Ternette N, van Veelen PA, van Els CACM, Heck AJR, de Souza GA, Sollid LM, Admon A, Stevanovic S, Rammensee HG, Thibault P, Perreault C, Bassani-Sternberg M, Aebersold R, Caron E. PMID: 28985418; PMCID: PMC5753376.
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Large-Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata. J Investig Dermatol Symp Proc. 2018 01; 19(1):S54-S56. Lindestam Arlehamn CS, Paul S, Chun Wang EH, de Jong A, Christiano AM, Sette A. PMID: 29273108.
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FAIR principles and the IEDB: short-term improvements and a long-term vision of OBO-foundry mediated machine-actionable interoperability. Database (Oxford). 2018 01 01; 2018. Vita R, Overton JA, Mungall CJ, Sette A, Peters B. PMID: 29688354; PMCID: PMC5819722.
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The Identification of Allergen-Derived T Cell Epitopes. Methods Mol Biol. 2018; 1799:153-163. Schulten V, Sette A. PMID: 29956151.
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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka. Hum Immunol. 2018 Feb; 79(2):87-88. Grifoni A, Weiskopf D, Lindestam Arlehamn CS, Angelo M, Leary S, Sidney J, Frazier A, Phillips E, Mallal S, Mack SJ, Tippalagama R, Goonewardana S, Premawansa S, Premawansa G, Wijewickrama A, De Silva AD, Sette A. PMID: 29289740; PMCID: PMC6378951.
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Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL. PLoS Negl Trop Dis. 2017 12; 11(12):e0006000. Ricciardi MJ, Magnani DM, Grifoni A, Kwon YC, Gutman MJ, Grubaugh ND, Gangavarapu K, Sharkey M, Silveira CGT, Bailey VK, Pedreño-Lopez N, Gonzalez-Nieto L, Maxwell HS, Domingues A, Martins MA, Pham J, Weiskopf D, Altman J, Kallas EG, Andersen KG, Stevenson M, Lichtenberger P, Choe H, Whitehead SS, Sette A, Watkins DI. PMID: 29267278; PMCID: PMC5755934.
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Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy. J Exp Med. 2018 01 02; 215(1):141-157. Chheda ZS, Kohanbash G, Okada K, Jahan N, Sidney J, Pecoraro M, Yang X, Carrera DA, Downey KM, Shrivastav S, Liu S, Lin Y, Lagisetti C, Chuntova P, Watchmaker PB, Mueller S, Pollack IF, Rajalingam R, Carcaboso AM, Mann M, Sette A, Garcia KC, Hou Y, Okada H. PMID: 29203539; PMCID: PMC5748856.
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Prior Dengue Virus Exposure Shapes T Cell Immunity to Zika Virus in Humans. J Virol. 2017 12 15; 91(24). Grifoni A, Pham J, Sidney J, O'Rourke PH, Paul S, Peters B, Martini SR, de Silva AD, Ricciardi MJ, Magnani DM, Silveira CGT, Maestri A, Costa PR, de-Oliveira-Pinto LM, de Azeredo EL, Damasco PV, Phillips E, Mallal S, de Silva AM, Collins M, Durbin A, Diehl SA, Cerpas C, Balmaseda A, Kuan G, Coloma J, Harris E, Crowe JE, Stone M, Norris PJ, Busch M, Vivanco-Cid H, Cox J, Graham BS, Ledgerwood JE, Turtle L, Solomon T, Kallas EG, Watkins DI, Weiskopf D, Sette A. PMID: 28978707; PMCID: PMC5709580.
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Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA. Nat Commun. 2017 11 13; 8(1):1473. Tian Y, Babor M, Lane J, Schulten V, Patil VS, Seumois G, Rosales SL, Fu Z, Picarda G, Burel J, Zapardiel-Gonzalo J, Tennekoon RN, De Silva AD, Premawansa S, Premawansa G, Wijewickrama A, Greenbaum JA, Vijayanand P, Weiskopf D, Sette A, Peters B. PMID: 29133794; PMCID: PMC5684192.
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Influenza-derived peptides cross-react with allergens and provide asthma protection. J Allergy Clin Immunol. 2018 09; 142(3):804-814. Skevaki C, Hudemann C, Matrosovich M, Möbs C, Paul S, Wachtendorf A, Alashkar Alhamwe B, Potaczek DP, Hagner S, Gemsa D, Garn H, Sette A, Renz H. PMID: 29132960.
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Novel Plasmodium antigens identified via genome-based antibody screen induce protection associated with polyfunctional T cell responses. Sci Rep. 2017 11 08; 7(1):15053. Schussek S, Trieu A, Apte SH, Sidney J, Sette A, Doolan DL. PMID: 29118376; PMCID: PMC5678182.
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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua. Hum Immunol. 2018 Jan; 79(1):1-2. Weiskopf D, Grifoni A, Arlehamn CSL, Angelo M, Leary S, Sidney J, Frazier A, Mack SJ, Phillips E, Mallal S, Cerpas C, Balmaseda A, Harris E, Sette A. PMID: 29122684; PMCID: PMC5788571.
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Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells. EMBO Mol Med. 2017 11; 9(11):1605-1621. Draheim M, Wlodarczyk MF, Crozat K, Saliou JM, Alayi TD, Tomavo S, Hassan A, Salvioni A, Demarta-Gatsi C, Sidney J, Sette A, Dalod M, Berry A, Silvie O, Blanchard N. PMID: 28935714; PMCID: PMC5666312.
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Global Assessment of Dengue Virus-Specific CD4+ T Cell Responses in Dengue-Endemic Areas. Front Immunol. 2017; 8:1309. Grifoni A, Angelo MA, Lopez B, O'Rourke PH, Sidney J, Cerpas C, Balmaseda A, Silveira CGT, Maestri A, Costa PR, Durbin AP, Diehl SA, Phillips E, Mallal S, De Silva AD, Nchinda G, Nkenfou C, Collins MH, de Silva AM, Lim MQ, Macary PA, Tatullo F, Solomon T, Satchidanandam V, Desai A, Ravi V, Coloma J, Turtle L, Rivino L, Kallas EG, Peters B, Harris E, Sette A, Weiskopf D. PMID: 29081779; PMCID: PMC5646259.
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Development of a strategy and computational application to select candidate protein analogues with reduced HLA binding and immunogenicity. Immunology. 2018 01; 153(1):118-132. Dhanda SK, Grifoni A, Pham J, Vaughan K, Sidney J, Peters B, Sette A. PMID: 28833085; PMCID: PMC5721253.
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Differential Recognition of Mycobacterium tuberculosis-Specific Epitopes as a Function of Tuberculosis Disease History. Am J Respir Crit Care Med. 2017 09 15; 196(6):772-781. Scriba TJ, Carpenter C, Pro SC, Sidney J, Musvosvi M, Rozot V, Seumois G, Rosales SL, Vijayanand P, Goletti D, Makgotlho E, Hanekom W, Hatherill M, Peters B, Sette A, Arlehamn CSL. PMID: 28759253; PMCID: PMC5620682.
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Erratum: T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. 2017 09 13; 549(7671):292. Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Arlehamn CSL, Sette A. PMID: 28905919; PMCID: PMC10204083.
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Protein nanovaccine confers robust immunity against Toxoplasma. NPJ Vaccines. 2017; 2:24. El Bissati K, Zhou Y, Paulillo SM, Raman SK, Karch CP, Roberts CW, Lanar DE, Reed S, Fox C, Carter D, Alexander J, Sette A, Sidney J, Lorenzi H, Begeman IJ, Burkhard P, McLeod R. PMID: 29263879; PMCID: PMC5627305.
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Large Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata. J Invest Dermatol. 2017 Aug 29. Lindestam Arlehamn CS, Paul S, Wang EHC, de Jong A, Christiano AM, Sette A. PMID: 28864075.
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Deciphering the MHC-associated peptidome: a review of naturally processed ligand data. Expert Rev Proteomics. 2017 09; 14(9):729-736. Vaughan K, Xu X, Caron E, Peters B, Sette A. PMID: 28756714.
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Erratum for Verma et al., "Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection". J Virol. 2017 09 01; 91(17). Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA. PMID: 28798100; PMCID: PMC5553172.
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Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases. Clin Vaccine Immunol. 2017 Jul; 24(7). Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE. PMID: 28490424; PMCID: PMC5498725.
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T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature. 2017 06 29; 546(7660):656-661. Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A. PMID: 28636593; PMCID: PMC5626019.
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Identifying specificity groups in the T cell receptor repertoire. Nature. 2017 07 06; 547(7661):94-98. Glanville J, Huang H, Nau A, Hatton O, Wagar LE, Rubelt F, Ji X, Han A, Krams SM, Pettus C, Haas N, Arlehamn CSL, Sette A, Boyd SD, Scriba TJ, Martinez OM, Davis MM. PMID: 28636589; PMCID: PMC5794212.
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Experimental validation of the RATE tool for inferring HLA restrictions of T cell epitopes. BMC Immunol. 2017 06 21; 18(Suppl 1):20. Paul S, Arlehamn CSL, Schulten V, Westernberg L, Sidney J, Peters B, Sette A. PMID: 28681704; PMCID: PMC5499093.
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Machine learning reveals a non-canonical mode of peptide binding to MHC class II molecules. Immunology. 2017 10; 152(2):255-264. Andreatta M, Jurtz VI, Kaever T, Sette A, Peters B, Nielsen M. PMID: 28542831; PMCID: PMC5588850.
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Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military personnel. Clin Immunol. 2017 08; 181:60-66. Ferlito C, Barnaba V, Abrignani S, Bombaci M, Sette A, Sidney J, Biselli R, Tomao E, Cattaruzza MS, Germano V, Biondo MI, Salerno G, Lulli P, Caporuscio S, Picchianti Diamanti A, Falco M, Biselli V, Cardelli P, Autore A, Lucertini E, De Cesare DP, Peragallo MS, Lista F, Martire C, Salemi S, Nisini R, D'Amelio R. PMID: 28625884.
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A Case of Human Lassa Virus Infection With Robust Acute T-Cell Activation and Long-Term Virus-Specific T-Cell Responses. J Infect Dis. 2017 06 15; 215(12):1862-1872. McElroy AK, Akondy RS, Harmon JR, Ellebedy AH, Cannon D, Klena JD, Sidney J, Sette A, Mehta AK, Kraft CS, Lyon MG, Varkey JB, Ribner BS, Nichol ST, Spiropoulou CF. PMID: 28863472; PMCID: PMC5853890.
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Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis. Cell Host Microbe. 2017 Jun 14; 21(6):695-706.e5. Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB. PMID: 28618268; PMCID: PMC5533182.
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The Immune Epitope Database: How Data Are Entered and Retrieved. J Immunol Res. 2017; 2017:5974574. Fleri W, Vaughan K, Salimi N, Vita R, Peters B, Sette A. PMID: 28634590; PMCID: PMC5467323.
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Bolstering the Number and Function of HSV-1-Specific CD8+ Effector Memory T Cells and Tissue-Resident Memory T Cells in Latently Infected Trigeminal Ganglia Reduces Recurrent Ocular Herpes Infection and Disease. J Immunol. 2017 07 01; 199(1):186-203. Khan AA, Srivastava R, Chentoufi AA, Kritzer E, Chilukuri S, Garg S, Yu DC, Vahed H, Huang L, Syed SA, Furness JN, Tran TT, Anthony NB, McLaren CE, Sidney J, Sette A, Noelle RJ, BenMohamed L. PMID: 28539429; PMCID: PMC5515716.
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Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol. 2018 02; 141(2):775-777.e6. Schulten V, Tripple V, Seumois G, Qian Y, Scheuermann RH, Fu Z, Locci M, Rosales S, Vijayanand P, Sette A, Alam R, Crotty S, Peters B. PMID: 28506846; PMCID: PMC5682232.
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Epitope-specific immunotherapy targeting CD4-positive T cells in coeliac disease: two randomised, double-blind, placebo-controlled phase 1 studies. Lancet Gastroenterol Hepatol. 2017 07; 2(7):479-493. Goel G, King T, Daveson AJ, Andrews JM, Krishnarajah J, Krause R, Brown GJE, Fogel R, Barish CF, Epstein R, Kinney TP, Miner PB, Tye-Din JA, Girardin A, Taavela J, Popp A, Sidney J, Mäki M, Goldstein KE, Griffin PH, Wang S, Dzuris JL, Williams LJ, Sette A, Xavier RJ, Sollid LM, Jabri B, Anderson RP. PMID: 28506538; PMCID: PMC5676538.
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Metabolic Phenotypes of Response to Vaccination in Humans. Cell. 2017 May 18; 169(5):862-877.e17. Li S, Sullivan NL, Rouphael N, Yu T, Banton S, Maddur MS, McCausland M, Chiu C, Canniff J, Dubey S, Liu K, Tran V, Hagan T, Duraisingham S, Wieland A, Mehta AK, Whitaker JA, Subramaniam S, Jones DP, Sette A, Vora K, Weinberg A, Mulligan MJ, Nakaya HI, Levin M, Ahmed R, Pulendran B. PMID: 28502771; PMCID: PMC5711477.
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Citrullination only infrequently impacts peptide binding to HLA class II MHC. PLoS One. 2017; 12(5):e0177140. Sidney J, Becart S, Zhou M, Duffy K, Lindvall M, Moore EC, Moore EL, Rao T, Rao N, Nielsen M, Peters B, Sette A. PMID: 28481943; PMCID: PMC5421785.
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Patterns of Cellular Immunity Associated with Experimental Infection with rDEN2Δ30 (Tonga/74) Support Its Suitability as a Human Dengue Virus Challenge Strain. J Virol. 2017 Apr 15; 91(8). Grifoni A, Angelo M, Sidney J, Paul S, Peters B, de Silva AD, Phillips E, Mallal S, Diehl SA, Botten J, Boyson J, Kirkpatrick BD, Whitehead SS, Durbin AP, Sette A, Weiskopf D. PMID: 28148797; PMCID: PMC5375662.
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Portrait of an optimist. Hum Vaccin Immunother. 2017 06 03; 13(6):1-3. Sette A. PMID: 28350507; PMCID: PMC5489282.
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Identification of Mycobacterial RplJ/L10 and RpsA/S1 Proteins as Novel Targets for CD4+ T Cells. Infect Immun. 2017 04; 85(4). Johnson AJ, Kennedy SC, Lindestam Arlehamn CS, Goldberg MF, Saini NK, Xu J, Paul S, Hegde SS, Blanchard JS, Chan J, Jacobs WR, Sette A, Porcelli SA. PMID: 28115505; PMCID: PMC5364311.
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Peptide-binding motifs of two common equine class I MHC molecules in Thoroughbred horses. Immunogenetics. 2017 05; 69(5):351-358. Bergmann T, Lindvall M, Moore E, Moore E, Sidney J, Miller D, Tallmadge RL, Myers PT, Malaker SA, Shabanowitz J, Osterrieder N, Peters B, Hunt DF, Antczak DF, Sette A. PMID: 28315936; PMCID: PMC5555743.
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Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya. Hum Immunol. 2017 Apr; 78(4):325-326. Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst JD, TBRU-ASTRa Study Team. PMID: 28315719; PMCID: PMC5519768.
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The Immune Epitope Database and Analysis Resource in Epitope Discovery and Synthetic Vaccine Design. Front Immunol. 2017; 8:278. Fleri W, Paul S, Dhanda SK, Mahajan S, Xu X, Peters B, Sette A. PMID: 28352270; PMCID: PMC5348633.
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Identification of Zika virus epitopes reveals immunodominant and protective roles for dengue virus cross-reactive CD8+ T cells. Nat Microbiol. 2017 Mar 13; 2:17036. Wen J, Tang WW, Sheets N, Ellison J, Sette A, Kim K, Shresta S. PMID: 28288094; PMCID: PMC5918137.
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Human CD4+ T Cell Responses to an Attenuated Tetravalent Dengue Vaccine Parallel Those Induced by Natural Infection in Magnitude, HLA Restriction, and Antigen Specificity. J Virol. 2017 03 01; 91(5). Angelo MA, Grifoni A, O'Rourke PH, Sidney J, Paul S, Peters B, de Silva AD, Phillips E, Mallal S, Diehl SA, Kirkpatrick BD, Whitehead SS, Durbin AP, Sette A, Weiskopf D. PMID: 27974563; PMCID: PMC5309943.
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Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination. J Virol. 2017 03 01; 91(5). Nivarthi UK, Kose N, Sapparapu G, Widman D, Gallichotte E, Pfaff JM, Doranz BJ, Weiskopf D, Sette A, Durbin AP, Whitehead SS, Baric R, Crowe JE, de Silva AM. PMID: 28031369; PMCID: PMC5309932.
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Gliadin-Specific CD8+ T Cell Responses Restricted by HLA Class I A*0101 and B*0801 Molecules in Celiac Disease Patients. J Immunol. 2017 03 01; 198(5):1838-1845. Picascia S, Sidney J, Camarca A, Mazzarella G, Giardullo N, Greco L, Auricchio R, Auricchio S, Troncone R, Sette A, Gianfrani C. PMID: 28148736.
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Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2017 02; 214(2):567. Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. PMID: 28096291; PMCID: PMC5294854.
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Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H781-H790. Kimura T, Tse K, McArdle S, Gerhardt T, Miller J, Mikulski Z, Sidney J, Sette A, Wolf D, Ley K. PMID: 28087520; PMCID: PMC5407161.
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Definition of Human Epitopes Recognized in Tetanus Toxoid and Development of an Assay Strategy to Detect Ex Vivo Tetanus CD4+ T Cell Responses. PLoS One. 2017; 12(1):e0169086. da Silva Antunes R, Paul S, Sidney J, Weiskopf D, Dan JM, Phillips E, Mallal S, Crotty S, Sette A, Lindestam Arlehamn CS. PMID: 28081174; PMCID: PMC5230748.
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An Integrated Workflow To Assess Technical and Biological Variability of Cell Population Frequencies in Human Peripheral Blood by Flow Cytometry. J Immunol. 2017 02 15; 198(4):1748-1758. Burel JG, Qian Y, Lindestam Arlehamn C, Weiskopf D, Zapardiel-Gonzalo J, Taplitz R, Gilman RH, Saito M, de Silva AD, Vijayanand P, Scheuermann RH, Sette A, Peters B. PMID: 28069807; PMCID: PMC5296239.
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Better living through ontologies at the Immune Epitope Database. Database (Oxford). 2017 01 01; 2017(1). Vita R, Overton JA, Sette A, Peters B. PMID: 28365732; PMCID: PMC5467561.
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It's a lot of work to be nonallergic. J Allergy Clin Immunol. 2017 03; 139(3):769-770. Sette A, Schulten V. PMID: 27993537; PMCID: PMC5465425.
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Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection. Front Immunol. 2016; 7:531. Tian Y, Sette A, Weiskopf D. PMID: 28003809; PMCID: PMC5141332.
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Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts. Ann Allergy Asthma Immunol. 2016 12; 117(6):680-689.e1. Oseroff C, Pham J, Frazier A, Hinz D, Sidney J, Paul S, Greenbaum JA, Vita R, Peters B, Schulten V, Sette A. PMID: 27979027; PMCID: PMC5172395.
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17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. Nat Commun. 2016 11 16; 7:13426. Schmiedel BJ, Seumois G, Samaniego-Castruita D, Cayford J, Schulten V, Chavez L, Ay F, Sette A, Peters B, Vijayanand P. PMID: 27848966; PMCID: PMC5116091.
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Identifying Candidate Targets of Immune Responses in Zika Virus Based on Homology to Epitopes in Other Flavivirus Species. PLoS Curr. 2016 Nov 15; 8. Xu X, Vaughan K, Weiskopf D, Grifoni A, Diamond MS, Sette A, Peters B. PMID: 28018746; PMCID: PMC5145810.
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Immunoproteomic analysis of house dust mite antigens reveals distinct classes of dominant T cell antigens according to function and serological reactivity. Clin Exp Allergy. 2017 Apr; 47(4):577-592. Oseroff C, Christensen LH, Westernberg L, Pham J, Lane J, Paul S, Greenbaum J, Stranzl T, Lund G, Hoof I, Holm J, Würtzen PA, Meno KH, Frazier A, Schulten V, Andersen PS, Peters B, Sette A. PMID: 27684489; PMCID: PMC5374056.
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A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science. 2016 10 21; 354(6310):354-358. Liepe J, Marino F, Sidney J, Jeko A, Bunting DE, Sette A, Kloetzel PM, Stumpf MP, Heck AJ, Mishto M. PMID: 27846572.
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HIV Interferes with Mycobacterium tuberculosis Antigen Presentation in Human Dendritic Cells. Am J Pathol. 2016 12; 186(12):3083-3093. Singh SK, Andersson AM, Ellegård R, Lindestam Arlehamn CS, Sette A, Larsson M, Stendahl O, Blomgran R. PMID: 27746182.
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Protective Role of Cross-Reactive CD8 T Cells Against Dengue Virus Infection. EBioMedicine. 2016 Nov; 13:284-293. Elong Ngono A, Chen HW, Tang WW, Joo Y, King K, Weiskopf D, Sidney J, Sette A, Shresta S. PMID: 27746192; PMCID: PMC5264312.
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Preventing tumor escape by targeting a post-proteasomal trimming independent epitope. J Exp Med. 2016 10 17; 213(11):2333-2348. Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T. PMID: 27697836; PMCID: PMC5068242.
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Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii. JCI Insight. 2016 09 22; 1(15):e85955. El Bissati K, Chentoufi AA, Krishack PA, Zhou Y, Woods S, Dubey JP, Vang L, Lykins J, Broderick KE, Mui E, Suzuki Y, Sa Q, Bi S, Cardona N, Verma SK, Fraczek L, Reardon CA, Sidney J, Alexander J, Sette A, Vedvick T, Fox C, Guderian JA, Reed S, Roberts CW, McLeod R. PMID: 27699241; PMCID: PMC5033759.
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TepiTool: A Pipeline for Computational Prediction of T Cell Epitope Candidates. Curr Protoc Immunol. 2016 08 01; 114:18.19.1-18.19.24. Paul S, Sidney J, Sette A, Peters B. PMID: 27479659; PMCID: PMC4981331.
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Reply. J Allergy Clin Immunol. 2016 10; 138(4):1237-1238. Westernberg L, Schulten V, Sette A, Peters B. PMID: 27484034.
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HLA-DRB1 Alleles Are Associated With Different Magnitudes of Dengue Virus-Specific CD4+ T-Cell Responses. J Infect Dis. 2016 10 01; 214(7):1117-24. Weiskopf D, Angelo MA, Grifoni A, O'Rourke PH, Sidney J, Paul S, De Silva AD, Phillips E, Mallal S, Premawansa S, Premawansa G, Wijewickrama A, Peters B, Sette A. PMID: 27443615; PMCID: PMC5021234.
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A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. PLoS Pathog. 2016 07; 12(7):e1005760. Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A. PMID: 27409590; PMCID: PMC4943605.
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A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood. J Immunol. 2016 08 01; 197(3):983-93. Dan JM, Lindestam Arlehamn CS, Weiskopf D, da Silva Antunes R, Havenar-Daughton C, Reiss SM, Brigger M, Bothwell M, Sette A, Crotty S. PMID: 27342848; PMCID: PMC4955771.
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Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. J Immunol. 2016 07 15; 197(2):655-64. Seumois G, Zapardiel-Gonzalo J, White B, Singh D, Schulten V, Dillon M, Hinz D, Broide DH, Sette A, Peters B, Vijayanand P. PMID: 27271570; PMCID: PMC4936908.
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Th1 versus Th2 T cell polarization by whole-cell and acellular childhood pertussis vaccines persists upon re-immunization in adolescence and adulthood. Cell Immunol. 2016 Jun-Jul; 304-305:35-43. Bancroft T, Dillon MB, da Silva Antunes R, Paul S, Peters B, Crotty S, Lindestam Arlehamn CS, Sette A. PMID: 27212461; PMCID: PMC4899275.
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Immunodominant Dengue Virus-Specific CD8+ T Cell Responses Are Associated with a Memory PD-1+ Phenotype. J Virol. 2016 May; 90(9):4771-4779. de Alwis R, Bangs DJ, Angelo MA, Cerpas C, Fernando A, Sidney J, Peters B, Gresh L, Balmaseda A, de Silva AD, Harris E, Sette A, Weiskopf D. PMID: 26912627; PMCID: PMC4836325.
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Erratum: RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection. Nat Commun. 2016 Mar 09; 7:11011. Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EH, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C. PMID: 26957359; PMCID: PMC4786878.
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T-cell epitope conservation across allergen species is a major determinant of immunogenicity. J Allergy Clin Immunol. 2016 08; 138(2):571-578.e7. Westernberg L, Schulten V, Greenbaum JA, Natali S, Tripple V, McKinney DM, Frazier A, Hofer H, Wallner M, Sallusto F, Sette A, Peters B. PMID: 26883464; PMCID: PMC4975972.
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T-cell recognition is shaped by epitope sequence conservation in the host proteome and microbiome. Immunology. 2016 May; 148(1):34-9. Bresciani A, Paul S, Schommer N, Dillon MB, Bancroft T, Greenbaum J, Sette A, Nielsen M, Peters B. PMID: 26789414; PMCID: PMC4819143.
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Reproducibility and conflicts in immune epitope data. Immunology. 2016 Mar; 147(3):349-54. Vita R, Vasilevsky N, Bandrowski A, Haendel M, Sette A, Peters B. PMID: 26678806; PMCID: PMC4754615.
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Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove. Elife. 2016 Jan 29; 5. McMurtrey C, Trolle T, Sansom T, Remesh SG, Kaever T, Bardet W, Jackson K, McLeod R, Sette A, Nielsen M, Zajonc DM, Blader IJ, Peters B, Hildebrand W. PMID: 26824387; PMCID: PMC4775218.
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The Length Distribution of Class I-Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele-Specific Binding Preference. J Immunol. 2016 Feb 15; 196(4):1480-7. Trolle T, McMurtrey CP, Sidney J, Bardet W, Osborn SC, Kaever T, Sette A, Hildebrand WH, Nielsen M, Peters B. PMID: 26783342; PMCID: PMC4744552.
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An ontology for major histocompatibility restriction. J Biomed Semantics. 2016; 7:1. Vita R, Overton JA, Seymour E, Sidney J, Kaufman J, Tallmadge RL, Ellis S, Hammond J, Butcher GW, Sette A, Peters B. PMID: 26759709; PMCID: PMC4709943.
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Characterization of the peptide binding specificity of the HLA class I alleles B*38:01 and B*39:06. Immunogenetics. 2016 Mar; 68(3):231-6. Sidney J, Schloss J, Moore C, Lindvall M, Wriston A, Hunt DF, Shabanowitz J, DiLorenzo TP, Sette A. PMID: 26754738; PMCID: PMC4760861.
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RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection. Nat Commun. 2015 Dec 21; 6:10224. Jozwik A, Habibi MS, Paras A, Zhu J, Guvenel A, Dhariwal J, Almond M, Wong EHC, Sykes A, Maybeno M, Del Rosario J, Trujillo-Torralbo MB, Mallia P, Sidney J, Peters B, Kon OM, Sette A, Johnston SL, Openshaw PJ, Chiu C. PMID: 26687547; PMCID: PMC4703893.
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T cell neoepitope discovery in colorectal cancer by high throughput profiling of somatic mutations in expressed genes. Gut. 2017 03; 66(3):454-463. Mennonna D, Maccalli C, Romano MC, Garavaglia C, Capocefalo F, Bordoni R, Severgnini M, De Bellis G, Sidney J, Sette A, Gori A, Longhi R, Braga M, Ghirardelli L, Baldari L, Orsenigo E, Albarello L, Zino E, Fleischhauer K, Mazzola G, Ferrero N, Amoroso A, Casorati G, Parmiani G, Dellabona P. PMID: 26681737; PMCID: PMC5534766.
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Deciphering the human antigenome. Expert Rev Vaccines. 2016; 15(2):167-71. Sette A, Schenkelberg TR, Koff WC. PMID: 26629807.
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The Use of the Immune Epitope Database to Study Autoimmune Epitope Data Related to Alopecia Areata. J Investig Dermatol Symp Proc. 2015 Nov; 17(2):36-41. Sette A, Paul S, Vaughan K, Peters B. PMID: 26551944; PMCID: PMC10198045.
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The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing. J Biol Chem. 2015 Dec 18; 290(51):30417-28. Textoris-Taube K, Keller C, Liepe J, Henklein P, Sidney J, Sette A, Kloetzel PM, Mishto M. PMID: 26507656; PMCID: PMC4683264.
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Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection. J Virol. 2016 01 15; 90(2):650-8. Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA. PMID: 26491148; PMCID: PMC4702662.
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Automatic Generation of Validated Specific Epitope Sets. J Immunol Res. 2015; 2015:763461. Carrasco Pro S, Sidney J, Paul S, Lindestam Arlehamn C, Weiskopf D, Peters B, Sette A. PMID: 26568965; PMCID: PMC4629045.
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The common equine class I molecule Eqca-1*00101 (ELA-A3.1) is characterized by narrow peptide binding and T cell epitope repertoires. Immunogenetics. 2015 Nov; 67(11-12):675-89. Bergmann T, Moore C, Sidney J, Miller D, Tallmadge R, Harman RM, Oseroff C, Wriston A, Shabanowitz J, Hunt DF, Osterrieder N, Peters B, Antczak DF, Sette A. PMID: 26399241; PMCID: PMC4783141.
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Apoptotic Epitope-Specific CD8+ T Cells and Interferon Signaling Intersect in Chronic Hepatitis C Virus Infection. J Infect Dis. 2016 Feb 15; 213(4):674-83. Martini H, Citro A, Martire C, D'Ettorre G, Labbadia G, Accapezzato D, Piconese S, De Marzio P, Cavallari EN, Calvo L, Rizzo F, Severa M, Coccia EM, Grazi GL, Di Filippo S, Sidney J, Vullo V, Sette A, Barnaba V. PMID: 26386427.
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The TB-specific CD4(+) T cell immune repertoire in both cynomolgus and rhesus macaques largely overlap with humans. Tuberculosis (Edinb). 2015 Dec; 95(6):722-735. Mothé BR, Lindestam Arlehamn CS, Dow C, Dillon MBC, Wiseman RW, Bohn P, Karl J, Golden NA, Gilpin T, Foreman TW, Rodgers MA, Mehra S, Scriba TJ, Flynn JL, Kaushal D, O'Connor DH, Sette A. PMID: 26526557; PMCID: PMC4773292.
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A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Tuberculosis (Edinb). 2015 Dec; 95(6):713-721. Carpenter C, Sidney J, Kolla R, Nayak K, Tomiyama H, Tomiyama C, Padilla OA, Rozot V, Ahamed SF, Ponte C, Rolla V, Antas PR, Chandele A, Kenneth J, Laxmi S, Makgotlho E, Vanini V, Ippolito G, Kazanova AS, Panteleev AV, Hanekom W, Mayanja-Kizza H, Lewinsohn D, Saito M, McElrath MJ, Boom WH, Goletti D, Gilman R, Lyadova IV, Scriba TJ, Kallas EG, Murali-Krishna K, Sette A, Lindestam Arlehamn CS. PMID: 26277695; PMCID: PMC4666753.
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Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):E4256-63. Weiskopf D, Bangs DJ, Sidney J, Kolla RV, De Silva AD, de Silva AM, Crotty S, Peters B, Sette A. PMID: 26195744; PMCID: PMC4534238.
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IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science. 2015 Aug 07; 349(6248):606-613. Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CSL, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. PMID: 26160376; PMCID: PMC4668938.
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An open-source computational and data resource to analyze digital maps of immunopeptidomes. Elife. 2015 Jul 08; 4. Caron E, Espona L, Kowalewski DJ, Schuster H, Ternette N, Alpízar A, Schittenhelm RB, Ramarathinam SH, Lindestam Arlehamn CS, Chiek Koh C, Gillet LC, Rabsteyn A, Navarro P, Kim S, Lam H, Sturm T, Marcilla M, Sette A, Campbell DS, Deutsch EW, Moritz RL, Purcell AW, Rammensee HG, Stevanovic S, Aebersold R. PMID: 26154972; PMCID: PMC4507788.
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CD8+ T Cells Specific to Apoptosis-Associated Antigens Predict the Response to Tumor Necrosis Factor Inhibitor Therapy in Rheumatoid Arthritis. PLoS One. 2015; 10(6):e0128607. Citro A, Scrivo R, Martini H, Martire C, De Marzio P, Vestri AR, Sidney J, Sette A, Barnaba V, Valesini G. PMID: 26061065; PMCID: PMC4465029.
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Development and validation of a sample sparing strategy for HLA typing utilizing next generation sequencing. Hum Immunol. 2015 Dec; 76(12):917-22. McKinney DM, Fu Z, Le L, Greenbaum JA, Peters B, Sette A. PMID: 26027778; PMCID: PMC4662932.
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Analysis of Human RSV Immunity at the Molecular Level: Learning from the Past and Present. PLoS One. 2015; 10(5):e0127108. Vaughan K, Ponomarenko J, Peters B, Sette A. PMID: 26001197; PMCID: PMC4441423.
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Human CD8+ T-Cell Responses Against the 4 Dengue Virus Serotypes Are Associated With Distinct Patterns of Protein Targets. J Infect Dis. 2015 Dec 01; 212(11):1743-51. Weiskopf D, Cerpas C, Angelo MA, Bangs DJ, Sidney J, Paul S, Peters B, Sanches FP, Silvera CG, Costa PR, Kallas EG, Gresh L, de Silva AD, Balmaseda A, Harris E, Sette A. PMID: 25980035; PMCID: PMC4633759.
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A population response analysis approach to assign class II HLA-epitope restrictions. J Immunol. 2015 Jun 15; 194(12):6164-6176. Paul S, Dillon MBC, Arlehamn CSL, Huang H, Davis MM, McKinney DM, Scriba TJ, Sidney J, Peters B, Sette A. PMID: 25948811; PMCID: PMC4458389.
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Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes. J Immunol Methods. 2015 Jul; 422:28-34. Paul S, Lindestam Arlehamn CS, Scriba TJ, Dillon MB, Oseroff C, Hinz D, McKinney DM, Carrasco Pro S, Sidney J, Peters B, Sette A. PMID: 25862607; PMCID: PMC4458426.
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Fine specificities of natural regulatory T cells after IVIG therapy in patients with Kawasaki disease. Autoimmunity. 2015 May; 48(3):181-8. Burns JC, Touma R, Song Y, Padilla RL, Tremoulet AH, Sidney J, Sette A, Franco A. PMID: 25822882; PMCID: PMC4784966.
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Human Ebola virus infection results in substantial immune activation. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):4719-24. McElroy AK, Akondy RS, Davis CW, Ellebedy AH, Mehta AK, Kraft CS, Lyon GM, Ribner BS, Varkey J, Sidney J, Sette A, Campbell S, Ströher U, Damon I, Nichol ST, Spiropoulou CF, Ahmed R. PMID: 25775592; PMCID: PMC4403189.
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Automated benchmarking of peptide-MHC class I binding predictions. Bioinformatics. 2015 Jul 01; 31(13):2174-81. Trolle T, Metushi IG, Greenbaum JA, Kim Y, Sidney J, Lund O, Sette A, Peters B, Nielsen M. PMID: 25717196; PMCID: PMC4481849.
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Vaccination to modulate atherosclerosis. Autoimmunity. 2015 May; 48(3):152-60. Kimura T, Tse K, Sette A, Ley K. PMID: 25683179; PMCID: PMC4429861.
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Identification of immunodominant CD4-restricted epitopes co-located with antibody binding sites in individuals vaccinated with ALVAC-HIV and AIDSVAX B/E. PLoS One. 2015; 10(2):e0115582. Ratto-Kim S, de Souza MS, Currier JR, Karasavvas N, Sidney J, Rolland M, Valencia-Micolta A, Madnote S, Sette A, Nitayaphan S, Pitisuttuthum P, Kaewkungwal J, Rerks-Ngarm S, O'Connell R, Michael N, Robb ML, Marovich M, Kim JH. PMID: 25665096; PMCID: PMC4321833.
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Consequences of periodic α-to-β(3) residue replacement for immunological recognition of peptide epitopes. ACS Chem Biol. 2015 Mar 20; 10(3):844-54. Cheloha RW, Sullivan JA, Wang T, Sand JM, Sidney J, Sette A, Cook ME, Suresh M, Gellman SH. PMID: 25559929; PMCID: PMC4372116.
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Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):E147-55. Lindestam Arlehamn CS, Paul S, Mele F, Huang C, Greenbaum JA, Vita R, Sidney J, Peters B, Sallusto F, Sette A. PMID: 25548174; PMCID: PMC4299226.
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New strategies for allergen T cell epitope identification: going beyond IgE. Int Arch Allergy Immunol. 2014; 165(2):75-82. Schulten V, Peters B, Sette A. PMID: 25402674; PMCID: PMC4315360.
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CD4 T cells specific for a latency-associated γ-herpesvirus epitope are polyfunctional and cytotoxic. J Immunol. 2014 Dec 15; 193(12):5827-34. Freeman ML, Burkum CE, Cookenham T, Roberts AD, Lanzer KG, Huston GE, Jensen MK, Sidney J, Peters B, Kohlmeier JE, Woodland DL, van Dyk LF, Sette A, Blackman MA. PMID: 25378595; PMCID: PMC4301266.
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Conservancy of mAb Epitopes in Ebolavirus Glycoproteins of Previous and 2014 Outbreaks. PLoS Curr. 2014 Nov 03; 6. Ponomarenko J, Vaughan K, Sette A, Maurer-Stroh S. PMID: 25642381; PMCID: PMC4234462.
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Allergy-associated T cell epitope repertoires are surprisingly diverse and include non-IgE reactive antigens. World Allergy Organ J. 2014; 7(1):26. Frazier A, Schulten V, Hinz D, Oseroff C, Sidney J, Peters B, Sette A. PMID: 25352946; PMCID: PMC4210551.
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The human CD8+ T cell responses induced by a live attenuated tetravalent dengue vaccine are directed against highly conserved epitopes. J Virol. 2015 Jan; 89(1):120-8. Weiskopf D, Angelo MA, Bangs DJ, Sidney J, Paul S, Peters B, de Silva AD, Lindow JC, Diehl SA, Whitehead S, Durbin A, Kirkpatrick B, Sette A. PMID: 25320311; PMCID: PMC4301095.
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The immune epitope database (IEDB) 3.0. Nucleic Acids Res. 2015 Jan; 43(Database issue):D405-12. Vita R, Overton JA, Greenbaum JA, Ponomarenko J, Clark JD, Cantrell JR, Wheeler DK, Gabbard JL, Hix D, Sette A, Peters B. PMID: 25300482; PMCID: PMC4384014.
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Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity. J Exp Med. 2014 Oct 20; 211(11):2231-48. Duan F, Duitama J, Al Seesi S, Ayres CM, Corcelli SA, Pawashe AP, Blanchard T, McMahon D, Sidney J, Sette A, Baker BM, Mandoiu II, Srivastava PK. PMID: 25245761; PMCID: PMC4203949.
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Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes. PLoS One. 2014; 9(9):e106241. Sedegah M, Hollingdale MR, Farooq F, Ganeshan H, Belmonte M, Kim Y, Peters B, Sette A, Huang J, McGrath S, Abot E, Limbach K, Shi M, Soisson L, Diggs C, Chuang I, Tamminga C, Epstein JE, Villasante E, Richie TL. PMID: 25211344; PMCID: PMC4161338.
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Bispecificity for myelin and neuronal self-antigens is a common feature of CD4 T cells in C57BL/6 mice. J Immunol. 2014 Oct 01; 193(7):3267-77. Lucca LE, Desbois S, Ramadan A, Ben-Nun A, Eisenstein M, Carrié N, Guéry JC, Sette A, Nguyen P, Geiger TL, Mars LT, Liblau RS. PMID: 25135834.
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Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features. J Immunol. 2014 Sep 15; 193(6):2931-40. Arlehamn CL, Seumois G, Gerasimova A, Huang C, Fu Z, Yue X, Sette A, Vijayanand P, Peters B. PMID: 25092889; PMCID: PMC4157075.
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Immunodominance changes as a function of the infecting dengue virus serotype and primary versus secondary infection. J Virol. 2014 Oct; 88(19):11383-94. Weiskopf D, Angelo MA, Sidney J, Peters B, Shresta S, Sette A. PMID: 25056881; PMCID: PMC4178794.
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Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol. 2014 Nov; 134(5):1076-83. Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. PMID: 25042980; PMCID: PMC4253970.
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Dataset size and composition impact the reliability of performance benchmarks for peptide-MHC binding predictions. BMC Bioinformatics. 2014 Jul 14; 15:241. Kim Y, Sidney J, Buus S, Sette A, Nielsen M, Peters B. PMID: 25017736; PMCID: PMC4111843.
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Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses. J Virol. 2014 Sep 01; 88(17):10078-91. Siciliano NA, Hersperger AR, Lacuanan AM, Xu RH, Sidney J, Sette A, Sigal LJ, Eisenlohr LC. PMID: 24965457; PMCID: PMC4136331.
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Antigens for CD4 and CD8 T cells in tuberculosis. Cold Spring Harb Perspect Med. 2014 May 22; 4(7):a018465. Lindestam Arlehamn CS, Lewinsohn D, Sette A, Lewinsohn D. PMID: 24852051; PMCID: PMC4066646.
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Analysis of HLA A*02 association with vaccine efficacy in the RV144 HIV-1 vaccine trial. J Virol. 2014 Aug; 88(15):8242-55. Gartland AJ, Li S, McNevin J, Tomaras GD, Gottardo R, Janes H, Fong Y, Morris D, Geraghty DE, Kijak GH, Edlefsen PT, Frahm N, Larsen BB, Tovanabutra S, Sanders-Buell E, deCamp AC, Magaret CA, Ahmed H, Goodridge JP, Chen L, Konopa P, Nariya S, Stoddard JN, Wong K, Zhao H, Deng W, Maust BS, Bose M, Howell S, Bates A, Lazzaro M, O'Sullivan A, Lei E, Bradfield A, Ibitamuno G, Assawadarachai V, O'Connell RJ, deSouza MS, Nitayaphan S, Rerks-Ngarm S, Robb ML, Sidney J, Sette A, Zolla-Pazner S, Montefiori D, McElrath MJ, Mullins JI, Kim JH, Gilbert PB, Hertz T. PMID: 24829343; PMCID: PMC4135964.
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Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog. 2014 Mar; 10(3):e1004008. Chiu C, McCausland M, Sidney J, Duh FM, Rouphael N, Mehta A, Mulligan M, Carrington M, Wieland A, Sullivan NL, Weinberg A, Levin MJ, Pulendran B, Peters B, Sette A, Ahmed R. PMID: 24675761; PMCID: PMC3968128.
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Definition of CD4 Immunosignatures Associated with MTB. Front Immunol. 2014; 5:124. Lindestam Arlehamn CS, Sette A. PMID: 24715893; PMCID: PMC3970006.
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T-cell immunity to infection with dengue virus in humans. Front Immunol. 2014; 5:93. Weiskopf D, Sette A. PMID: 24639680; PMCID: PMC3945531.
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Substantial gaps in knowledge of Bordetella pertussis antibody and T cell epitopes relevant for natural immunity and vaccine efficacy. Hum Immunol. 2014 May; 75(5):440-51. Vaughan K, Seymour E, Peters B, Sette A. PMID: 24530743; PMCID: PMC4792526.
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Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100. Front Immunol. 2013; 4:493. Tse K, Gonen A, Sidney J, Ouyang H, Witztum JL, Sette A, Tse H, Ley K. PMID: 24416033; PMCID: PMC3873602.
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A molecular view of multiple sclerosis and experimental autoimmune encephalitis: what can we learn from the epitope data? J Neuroimmunol. 2014 Feb 15; 267(1-2):73-85. Vaughan K, Peters B, O'Connor KC, Martin R, Sette A. PMID: 24365494; PMCID: PMC4784960.
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HLA class I alleles are associated with peptide-binding repertoires of different size, affinity, and immunogenicity. J Immunol. 2013 Dec 15; 191(12):5831-9. Paul S, Weiskopf D, Angelo MA, Sidney J, Peters B, Sette A. PMID: 24190657; PMCID: PMC3872965.
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Properties of MHC class I presented peptides that enhance immunogenicity. PLoS Comput Biol. 2013 Oct; 9(10):e1003266. Calis JJ, Maybeno M, Greenbaum JA, Weiskopf D, De Silva AD, Sette A, Kesmir C, Peters B. PMID: 24204222; PMCID: PMC3808449.
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Brucella melitensis T cell epitope recognition in humans with brucellosis in Peru. Infect Immun. 2014 Jan; 82(1):124-31. Cannella AP, Arlehamn CS, Sidney J, Patra KP, Torres K, Tsolis RM, Liang L, Felgner PL, Saito M, Gotuzzo E, Gilman RH, Sette A, Vinetz JM. PMID: 24126518; PMCID: PMC3911835.
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Identification of conserved and HLA promiscuous DENV3 T-cell epitopes. PLoS Negl Trop Dis. 2013; 7(10):e2497. Nascimento EJ, Mailliard RB, Khan AM, Sidney J, Sette A, Guzman N, Paulaitis M, de Melo AB, Cordeiro MT, Gil LV, Lemonnier F, Rinaldo C, August JT, Marques ET. PMID: 24130917; PMCID: PMC3794980.
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Structure-based design of altered MHC class II-restricted peptide ligands with heterogeneous immunogenicity. J Immunol. 2013 Nov 15; 191(10):5097-106. Chen S, Li Y, Depontieu FR, McMiller TL, English AM, Shabanowitz J, Kos F, Sidney J, Sette A, Rosenberg SA, Hunt DF, Mariuzza RA, Topalian SL. PMID: 24108701; PMCID: PMC3888030.
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Evaluating the immunogenicity of protein drugs by applying in vitro MHC binding data and the immune epitope database and analysis resource. Clin Dev Immunol. 2013; 2013:467852. Paul S, Kolla RV, Sidney J, Weiskopf D, Fleri W, Kim Y, Peters B, Sette A. PMID: 24222776; PMCID: PMC3816028.
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Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes. J Immunol. 2013 Nov 15; 191(10):5124-38. Dervillez X, Qureshi H, Chentoufi AA, Khan AA, Kritzer E, Yu DC, Diaz OR, Gottimukkala C, Kalantari M, Villacres MC, Scarfone VM, McKinney DM, Sidney J, Sette A, Nesburn AB, Wechsler SL, BenMohamed L. PMID: 24101547; PMCID: PMC4057607.
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Characterizing monkeypox virus specific CD8+ T cell epitopes in rhesus macaques. Virology. 2013 Dec; 447(1-2):181-6. Song H, Sidney J, Wiseman RW, Josleyn N, Cohen M, Blaney JE, Jahrling PB, Sette A. PMID: 24210113; PMCID: PMC4771384.
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Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity. 2013 Oct 17; 39(4):758-69. Locci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, Su LF, Cubas R, Davis MM, Sette A, Haddad EK, International AIDS Vaccine Initiative Protocol C Principal Investigators, Poignard P, Crotty S. PMID: 24035365; PMCID: PMC3996844.
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CD4(+) T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4(+) T cells during chronic infection. Immunology. 2013 Sep; 140(1):61-9. Dow C, Henderson R, Sette A, Mothé BR. PMID: 23566283; PMCID: PMC3809706.
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HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T cell epitope. J Hepatol. 2014 Jan; 60(1):22-9. Nitschke K, Barriga A, Schmidt J, Timm J, Viazov S, Kuntzen T, Kim AY, Lauer GM, Allen TM, Gaudieri S, Rauch A, Lange CM, Sarrazin C, Eiermann T, Sidney J, Sette A, Thimme R, López D, Neumann-Haefelin C. PMID: 23978718; PMCID: PMC3867523.
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HLA shared epitope and ACPA: just a marker or an active player? Autoimmun Rev. 2013 Oct; 12(12):1182-7. Pratesi F, Petit Teixeira E, Sidney J, Michou L, Puxeddu I, Sette A, Cornelis F, Migliorini P. PMID: 23958703.
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Local CD4 and CD8 T-cell reactivity to HSV-1 antigens documents broad viral protein expression and immune competence in latently infected human trigeminal ganglia. PLoS Pathog. 2013 Aug; 9(8):e1003547. van Velzen M, Jing L, Osterhaus AD, Sette A, Koelle DM, Verjans GM. PMID: 23966859; PMCID: PMC3744444.
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Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis. J Neuroinflammation. 2013 Jul 27; 10:94. Lolli F, Martini H, Citro A, Franceschini D, Portaccio E, Amato MP, Mechelli R, Annibali V, Sidney J, Sette A, Salvetti M, Barnaba V. PMID: 23890271; PMCID: PMC3734107.
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Immunization with apical membrane antigen 1 confers sterile infection-blocking immunity against Plasmodium sporozoite challenge in a rodent model. Infect Immun. 2013 Oct; 81(10):3586-99. Schussek S, Trieu A, Apte SH, Sidney J, Sette A, Doolan DL. PMID: 23836827; PMCID: PMC3811765.
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CD8+ T-cell epitope mapping for pneumonia virus of mice in H-2b mice. J Virol. 2013 Sep; 87(17):9949-52. Walsh KB, Sidney J, Welch M, Fremgen DM, Sette A, Oldstone MB. PMID: 23824814; PMCID: PMC3754129.
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Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control. Nat Med. 2013 Jul; 19(7):930-3. Ranasinghe S, Cutler S, Davis I, Lu R, Soghoian DZ, Qi Y, Sidney J, Kranias G, Flanders MD, Lindqvist M, Kuhl B, Alter G, Deeks SG, Walker BD, Gao X, Sette A, Carrington M, Streeck H. PMID: 23793098; PMCID: PMC3974408.
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Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol. 2013 Jul 15; 191(2):540-4. Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sékaly RP, Kaufmann DE. PMID: 23772031; PMCID: PMC3702641.
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Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP). Malar J. 2013 Jun 05; 12:185. Sedegah M, Kim Y, Ganeshan H, Huang J, Belmonte M, Abot E, Banania JG, Farooq F, McGrath S, Peters B, Sette A, Soisson L, Diggs C, Doolan DL, Tamminga C, Villasante E, Hollingdale MR, Richie TL. PMID: 23738590; PMCID: PMC3683343.
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Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell. 2013 Apr 15; 23(4):516-26. Engels B, Engelhard VH, Sidney J, Sette A, Binder DC, Liu RB, Kranz DM, Meredith SC, Rowley DA, Schreiber H. PMID: 23597565; PMCID: PMC3658176.
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Query enhancement through the practical application of ontology: the IEDB and OBI. J Biomed Semantics. 2013 Apr 15; 4 Suppl 1:S6. Vita R, Overton JA, Greenbaum JA, Sette A, OBI consortium, Peters B. PMID: 23734660; PMCID: PMC3633001.
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Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E2046-53. Weiskopf D, Angelo MA, de Azeredo EL, Sidney J, Greenbaum JA, Fernando AN, Broadwater A, Kolla RV, De Silva AD, de Silva AM, Mattia KA, Doranz BJ, Grey HM, Shresta S, Peters B, Sette A. PMID: 23580623; PMCID: PMC3670335.
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Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest. 2013 May; 123(5):1976-87. Gilchuk P, Spencer CT, Conant SB, Hill T, Gray JJ, Niu X, Zheng M, Erickson JJ, Boyd KL, McAfee KJ, Oseroff C, Hadrup SR, Bennink JR, Hildebrand W, Edwards KM, Crowe JE, Williams JV, Buus S, Sette A, Schumacher TN, Link AJ, Joyce S. PMID: 23543059; PMCID: PMC3635741.
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The nucleocapsid protein of Rift Valley fever virus is a potent human CD8+ T cell antigen and elicits memory responses. PLoS One. 2013; 8(3):e59210. Xu W, Watts DM, Costanzo MC, Tang X, Venegas LA, Jiao F, Sette A, Sidney J, Sewell AK, Wooldridge L, Makino S, Morrill JC, Peters CJ, Kan-Mitchell J. PMID: 23527138; PMCID: PMC3601065.
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Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol. 2013 May; 43(5):1162-72. Spencer CT, Dragovic SM, Conant SB, Gray JJ, Zheng M, Samir P, Niu X, Moutaftsi M, Van Kaer L, Sette A, Link AJ, Joyce S. PMID: 23386199; PMCID: PMC3798073.
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Peptide-binding motifs associated with MHC molecules common in Chinese rhesus macaques are analogous to those of human HLA supertypes and include HLA-B27-like alleles. Immunogenetics. 2013 May; 65(5):371-86. Mothé BR, Southwood S, Sidney J, English AM, Wriston A, Hoof I, Shabanowitz J, Hunt DF, Sette A. PMID: 23417323; PMCID: PMC3633659.
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Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3459-64. Schulten V, Greenbaum JA, Hauser M, McKinney DM, Sidney J, Kolla R, Lindestam Arlehamn CS, Oseroff C, Alam R, Broide DH, Ferreira F, Ferreira-Briza F, Grey HM, Sette A, Peters B. PMID: 23401558; PMCID: PMC3587276.
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A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population. Immunogenetics. 2013 May; 65(5):357-70. McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A. PMID: 23392739; PMCID: PMC3633633.
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Measurement of MHC/peptide interactions by gel filtration or monoclonal antibody capture. Curr Protoc Immunol. 2013 Feb; Chapter 18:Unit 18.3.. Sidney J, Southwood S, Moore C, Oseroff C, Pinilla C, Grey HM, Sette A. PMID: 23392640; PMCID: PMC3626435.
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T-cell memory responses elicited by yellow fever vaccine are targeted to overlapping epitopes containing multiple HLA-I and -II binding motifs. PLoS Negl Trop Dis. 2013; 7(1):e1938. de Melo AB, Nascimento EJ, Braga-Neto U, Dhalia R, Silva AM, Oelke M, Schneck JP, Sidney J, Sette A, Montenegro SM, Marques ET. PMID: 23383350; PMCID: PMC3561163.
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Positional bias of MHC class I restricted T-cell epitopes in viral antigens is likely due to a bias in conservation. PLoS Comput Biol. 2013; 9(1):e1002884. Kim Y, Yewdell JW, Sette A, Peters B. PMID: 23357871; PMCID: PMC3554532.
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Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset. PLoS Pathog. 2013 Jan; 9(1):e1003130. Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A. PMID: 23358848; PMCID: PMC3554618.
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Immunogenic peptides can be detected in whole gluten by transamidating highly susceptible glutamine residues: implication in the search for gluten-free cereals. J Agric Food Chem. 2013 Jan 23; 61(3):747-54. Mamone G, Camarca A, Fierro O, Sidney J, Mazzarella G, Addeo F, Auricchio S, Troncone R, Sette A, Gianfrani C. PMID: 23244345.
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Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB). Immunome Res. 2013; 9(1). Vaughan K, Peters B, Mallone R, von Herrath M, Roep BO, Sette A. PMID: 25140192; PMCID: PMC4134942.
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A comparison of epitope repertoires associated with myasthenia gravis in humans and nonhuman hosts. Autoimmune Dis. 2012; 2012:403915. Vaughan K, Kim Y, Sette A. PMID: 23243503; PMCID: PMC3518085.
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Strategies to query and display allergy-derived epitope data from the immune epitope database. Int Arch Allergy Immunol. 2013; 160(4):334-45. Vaughan K, Peters B, Larche M, Pomes A, Broide D, Sette A. PMID: 23172234; PMCID: PMC3629817.
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The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol. 2013 Jan; 110(1):7-10. Schulten V, Oseroff C, Alam R, Broide D, Vijayanand P, Peters B, Sette A. PMID: 23244651; PMCID: PMC3547526.
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The immune epitope database: a historical retrospective of the first decade. Immunology. 2012 Oct; 137(2):117-23. Salimi N, Fleri W, Peters B, Sette A. PMID: 22681406; PMCID: PMC3461392.
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Broad and cross-clade CD4+ T-cell responses elicited by a DNA vaccine encoding highly conserved and promiscuous HIV-1 M-group consensus peptides. PLoS One. 2012; 7(9):e45267. Almeida RR, Rosa DS, Ribeiro SP, Santana VC, Kallás EG, Sidney J, Sette A, Kalil J, Cunha-Neto E. PMID: 23028895; PMCID: PMC3445454.
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Polyfunctional CD4+ T cell responses to immunodominant epitopes correlate with disease activity of virulent Salmonella. PLoS One. 2012; 7(8):e43481. Maybeno M, Redeker A, Welten SP, Peters B, Loughhead SM, Schoenberger SP, Sette A, Arens R. PMID: 22912884; PMCID: PMC3422266.
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T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts. J Immunol. 2012 Aug 15; 189(4):1800-11. Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A. PMID: 22786768; PMCID: PMC3411923.
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Effect of rheumatoid arthritis (RA) susceptibility genes on the immune response to viral citrullinated peptides in RA. J Rheumatol. 2012 Jul; 39(7):1490-3. Pratesi F, Petit-Teixeira E, Sidney J, Teixeira VH, Puxeddu I, Sette A, Cornelis F, Migliorini P. PMID: 22753806.
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Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease. J Virol. 2012 Sep; 86(18):9748-59. Remakus S, Rubio D, Ma X, Sette A, Sigal LJ. PMID: 22740418; PMCID: PMC3446599.
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Polyfunctional type-1, -2, and -17 CD8⁺ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. PLoS Pathog. 2012; 8(6):e1002759. Franceschini D, Del Porto P, Piconese S, Trella E, Accapezzato D, Paroli M, Morrone S, Piccolella E, Spada E, Mele A, Sidney J, Sette A, Barnaba V. PMID: 22737070; PMCID: PMC3380931.
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Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production. J Immunol. 2012 Jul 15; 189(2):679-88. Oseroff C, Sidney J, Tripple V, Grey H, Wood R, Broide DH, Greenbaum J, Kolla R, Peters B, Pomés A, Sette A. PMID: 22706084; PMCID: PMC3392449.
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A meta-analysis of the existing knowledge of immunoreactivity against hepatitis C virus (HCV). PLoS One. 2012; 7(5):e38028. Kim Y, Vaughan K, Greenbaum J, Peters B, Law M, Sette A. PMID: 22675428; PMCID: PMC3364976.
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Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9959-64. Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B. PMID: 22645359; PMCID: PMC3382472.
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Immune epitope database analysis resource. Nucleic Acids Res. 2012 Jul; 40(Web Server issue):W525-30. Kim Y, Ponomarenko J, Zhu Z, Tamang D, Wang P, Greenbaum J, Lundegaard C, Sette A, Lund O, Bourne PE, Nielsen M, Peters B. PMID: 22610854; PMCID: PMC3394288.
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Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7847-52. Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, Anderson MS. PMID: 22552229; PMCID: PMC3356674.
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Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol. 2012 Jun 01; 188(11):5766-75. Antal Z, Baker JC, Smith C, Jarchum I, Babad J, Mukherjee G, Yang Y, Sidney J, Sette A, Santamaria P, DiLorenzo TP. PMID: 22539795; PMCID: PMC3358524.
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Immunogenicity and cross-reactivity of a representative ancestral sequence in hepatitis C virus infection. J Immunol. 2012 May 15; 188(10):5177-88. Burke KP, Munshaw S, Osburn WO, Levine J, Liu L, Sidney J, Sette A, Ray SC, Cox AL. PMID: 22508927; PMCID: PMC3345099.
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Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ). J Immunol. 2012 May 15; 188(10):5020-31. Arlehamn CS, Sidney J, Henderson R, Greenbaum JA, James EA, Moutaftsi M, Coler R, McKinney DM, Park D, Taplitz R, Kwok WW, Grey H, Peters B, Sette A. PMID: 22504645; PMCID: PMC3345088.
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Spleen cells from young but not old immunized mice eradicate large established cancers. Clin Cancer Res. 2012 May 01; 18(9):2526-33. Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. PMID: 22415314; PMCID: PMC5354938.
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A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules. Immunogenetics. 2012 Jun; 64(6):421-34. Sette A, Sidney J, Southwood S, Moore C, Berry J, Dow C, Bradley K, Hoof I, Lewis MG, Hildebrand WH, McMurtrey CP, Wilson NA, Watkins DI, Mothé BR. PMID: 22322672; PMCID: PMC3349854.
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Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. Front Cell Infect Microbiol. 2012; 2:1. Cannella AP, Tsolis RM, Liang L, Felgner PL, Saito M, Sette A, Gotuzzo E, Vinetz JM. PMID: 22919593; PMCID: PMC3417515.
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Identification of the peptide-binding motif recognized by the pigtail macaque class I MHC molecule Mane-A1*082:01 (Mane A*0301). Immunogenetics. 2012 Jun; 64(6):461-8. Moore C, Sidney J, English AM, Wriston A, Hunt DF, Shabanowitz J, Southwood S, Bradley K, Lafont BA, Mothé BR, Sette A. PMID: 22278177; PMCID: PMC3626442.
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Cost sensitive hierarchical document classification to triage PubMed abstracts for manual curation. BMC Bioinformatics. 2011 Dec 19; 12:482. Seymour E, Damle R, Sette A, Peters B. PMID: 22182279; PMCID: PMC3314711.
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Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1. J Acquir Immune Defic Syndr. 2011 11 01; 58(3):248-52. Friedrich D, Jalbert E, Dinges WL, Sidney J, Sette A, Huang Y, McElrath MJ, Horton H. PMID: 21709567; PMCID: PMC3196811.
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Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice. Hum Immunol. 2012 Jan; 73(1):1-10. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, El Bissati K, Zhou Y, Suzuki Y, Lee D, Woods S, Sommerville C, Henriquez FL, Roberts CW, McLeod R. PMID: 22027386; PMCID: PMC3246109.
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Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations. Hepatology. 2011 Oct; 54(4):1157-66. Neumann-Haefelin C, Oniangue-Ndza C, Kuntzen T, Schmidt J, Nitschke K, Sidney J, Caillet-Saguy C, Binder M, Kersting N, Kemper MW, Power KA, Ingber S, Reyor LL, Hills-Evans K, Kim AY, Lauer GM, Lohmann V, Sette A, Henn MR, Bressanelli S, Thimme R, Allen TM. PMID: 22006856; PMCID: PMC3201753.
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Insights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design. J Immunol. 2011 Oct 15; 187(8):4268-79. Weiskopf D, Yauch LE, Angelo MA, John DV, Greenbaum JA, Sidney J, Kolla RV, De Silva AD, de Silva AM, Grey H, Peters B, Shresta S, Sette A. PMID: 21918184; PMCID: PMC3186824.
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Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection. J Virol. 2011 Nov; 85(22):11770-80. Kotturi MF, Swann JA, Peters B, Arlehamn CL, Sidney J, Kolla RV, James EA, Akondy RS, Ahmed R, Kwok WW, Buchmeier MJ, Sette A. PMID: 21900169; PMCID: PMC3209290.
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High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control. J Virol. 2011 Sep; 85(18):9334-45. Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, Henry LM, Brenchley JM, Ruff LE, Venturi V, Pereyra F, Sidney J, Sette A, Douek DC, Walker BD, Kaufmann DE, Brander C. PMID: 21752903; PMCID: PMC3165743.
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The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection. Immunogenetics. 2011 Dec; 63(12):789-807. Reed JS, Sidney J, Piaskowski SM, Glidden CE, León EJ, Burwitz BJ, Kolar HL, Eernisse CM, Furlott JR, Maness NJ, Walsh AD, Rudersdorf RA, Bardet W, McMurtrey CP, O'Connor DH, Hildebrand WH, Sette A, Watkins DI, Wilson NA. PMID: 21732180; PMCID: PMC3706270.
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Targeting OX40 promotes lung-resident memory CD8 T cell populations that protect against respiratory poxvirus infection. J Virol. 2011 Sep; 85(17):9051-9. Salek-Ardakani S, Moutaftsi M, Sette A, Croft M. PMID: 21715499; PMCID: PMC3165842.
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A computational pipeline to generate MHC binding motifs. Immunome Res. 2011 May; 7(2). Wang P, Sidney J, Sette A, Peters B. PMID: 28747991; PMCID: PMC5524134.
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Defining the herpes simplex virus-specific CD8+ T cell repertoire in C57BL/6 mice. J Immunol. 2011 Apr 01; 186(7):3927-33. St Leger AJ, Peters B, Sidney J, Sette A, Hendricks RL. PMID: 21357536; PMCID: PMC3308013.
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Towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data. J Allergy (Cairo). 2010; 2010:628026. Vaughan K, Greenbaum J, Kim Y, Vita R, Chung J, Peters B, Broide D, Goodman R, Grey H, Sette A. PMID: 21403821; PMCID: PMC3042621.
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Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypes. Immunogenetics. 2011 Jun; 63(6):325-35. Greenbaum J, Sidney J, Chung J, Brander C, Peters B, Sette A. PMID: 21305276; PMCID: PMC3626422.
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Functional analysis of frequently expressed Chinese rhesus macaque MHC class I molecules Mamu-A1*02601 and Mamu-B*08301 reveals HLA-A2 and HLA-A3 supertypic specificities. Immunogenetics. 2011 May; 63(5):275-90. Southwood S, Solomon C, Hoof I, Rudersdorf R, Sidney J, Peters B, Wahl A, Hawkins O, Hildebrand W, Mothé BR, Sette A. PMID: 21274527; PMCID: PMC3068250.
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Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii. Immunome Res. 2010 Dec 03; 6:12. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R. PMID: 21129215; PMCID: PMC3009956.
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Peptide binding predictions for HLA DR, DP and DQ molecules. BMC Bioinformatics. 2010 Nov 22; 11:568. Wang P, Sidney J, Kim Y, Sette A, Lund O, Nielsen M, Peters B. PMID: 21092157; PMCID: PMC2998531.
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Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201. Vaccine. 2011 Jan 17; 29(4):754-62. Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R. PMID: 21095258; PMCID: PMC3014376.
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Applications for T-cell epitope queries and tools in the Immune Epitope Database and Analysis Resource. J Immunol Methods. 2011 Nov 30; 374(1-2):62-9. Kim Y, Sette A, Peters B. PMID: 21047510; PMCID: PMC3041860.
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Reverse vaccinology: developing vaccines in the era of genomics. Immunity. 2010 Oct 29; 33(4):530-41. Sette A, Rappuoli R. PMID: 21029963; PMCID: PMC3320742.
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IEDB-3D: structural data within the immune epitope database. Nucleic Acids Res. 2011 Jan; 39(Database issue):D1164-70. Ponomarenko J, Papangelopoulos N, Zajonc DM, Peters B, Sette A, Bourne PE. PMID: 21030437; PMCID: PMC3013771.
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CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination. J Immunol. 2010 Nov 01; 185(9):5405-16. Yauch LE, Prestwood TR, May MM, Morar MM, Zellweger RM, Peters B, Sette A, Shresta S. PMID: 20870934; PMCID: PMC2962919.
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Divergent motifs but overlapping binding repertoires of six HLA-DQ molecules frequently expressed in the worldwide human population. J Immunol. 2010 Oct 01; 185(7):4189-98. Sidney J, Steen A, Moore C, Ngo S, Chung J, Peters B, Sette A. PMID: 20810981; PMCID: PMC3307390.
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Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein. Malar J. 2010 Aug 24; 9:241. Sedegah M, Kim Y, Peters B, McGrath S, Ganeshan H, Lejano J, Abot E, Banania G, Belmonte M, Sayo R, Farooq F, Doolan DL, Regis D, Tamminga C, Chuang I, Bruder JT, King CR, Ockenhouse CF, Faber B, Remarque E, Hollingdale MR, Richie TL, Sette A. PMID: 20735847; PMCID: PMC2939619.
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A multivalent vaccination strategy for the prevention of Old World arenavirus infection in humans. J Virol. 2010 Oct; 84(19):9947-56. Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Kotturi MF, Sette A, Buchmeier MJ. PMID: 20668086; PMCID: PMC2937778.
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Unexpected diversity of cellular immune responses against Nef and Vif in HIV-1-infected patients who spontaneously control viral replication. PLoS One. 2010 Jul 02; 5(7):e11436. Tarosso LF, Sauer MM, Sanabani S, Giret MT, Tomiyama HI, Sidney J, Piaskowski SM, Diaz RS, Sabino EC, Sette A, Kalil-Filho J, Watkins DI, Kallas EG. PMID: 20625436; PMCID: PMC2896403.
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Generation of robust CD8+ T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes. Eur J Immunol. 2010 Jul; 40(7):1950-62. Schaubert KL, Price DA, Salkowitz JR, Sewell AK, Sidney J, Asher TE, Blondelle SE, Adams S, Marincola FM, Joseph A, Sette A, Douek DC, Ayyavoo V, Storkus W, Leung MY, Ng HL, Yang OO, Goldstein H, Wilson DB, Kan-Mitchell J. PMID: 20432235; PMCID: PMC3086652.
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Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol. 2010 Jul 15; 185(2):943-55. Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. PMID: 20554959; PMCID: PMC3310373.
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Coverage of related pathogenic species by multivalent and cross-protective vaccine design: arenaviruses as a model system. Microbiol Mol Biol Rev. 2010 Jun; 74(2):157-70. Botten J, Sidney J, Mothé BR, Peters B, Sette A, Kotturi MF. PMID: 20508245; PMCID: PMC2884409.
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Meta-analysis of all immune epitope data in the Flavivirus genus: inventory of current immune epitope data status in the context of virus immunity and immunopathology. Viral Immunol. 2010 Jun; 23(3):259-84. Vaughan K, Greenbaum J, Blythe M, Peters B, Sette A. PMID: 20565291; PMCID: PMC2942863.
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The CD4+ T-cell epitope-binding register is a critical parameter when generating functional HLA-DR tetramers with promiscuous peptides. Eur J Immunol. 2010 Jun; 40(6):1603-16. Cecconi V, Moro M, Del Mare S, Sidney J, Bachi A, Longhi R, Sette A, Protti MP, Dellabona P, Casorati G. PMID: 20306469.
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The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype. Immunogenetics. 2010 Jul; 62(7):451-64. Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR. PMID: 20480161; PMCID: PMC2890073.
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Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage. Immunome Res. 2010 May 17; 6:4. Kotturi MF, Botten J, Maybeno M, Sidney J, Glenn J, Bui HH, Oseroff C, Crotty S, Peters B, Grey H, Altmann DM, Buchmeier MJ, Sette A. PMID: 20478058; PMCID: PMC2880318.
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IMMUNOCAT-a data management system for epitope mapping studies. J Biomed Biotechnol. 2010; 2010:856842. Chung JL, Sun J, Sidney J, Sette A, Peters B. PMID: 20490281; PMCID: PMC2871663.
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Structural basis for the presentation of tumor-associated MHC class II-restricted phosphopeptides to CD4+ T cells. J Mol Biol. 2010 Jun 18; 399(4):596-603. Li Y, Depontieu FR, Sidney J, Salay TM, Engelhard VH, Hunt DF, Sette A, Topalian SL, Mariuzza RA. PMID: 20417641; PMCID: PMC2904831.
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TiArA: a virtual appliance for the analysis of Tiling Array data. PLoS One. 2010 Apr 01; 5(4):e9993. Greenbaum JA, Assarsson E, Chung JL, Head S, Sette A, Peters B. PMID: 20376318; PMCID: PMC2848623.
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Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans. Vaccine. 2010 May 21; 28(23):3977-89. Tan TG, Mui E, Cong H, Witola WH, Montpetit A, Muench SP, Sidney J, Alexander J, Sette A, Grigg ME, Maewal A, McLeod R. PMID: 20347630; PMCID: PMC2895808.
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Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus. Hum Immunol. 2010 May; 71(5):468-74. Alexander J, Bilsel P, del Guercio MF, Marinkovic-Petrovic A, Southwood S, Stewart S, Ishioka G, Kotturi MF, Botten J, Sidney J, Newman M, Sette A. PMID: 20156506; PMCID: PMC2856764.
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Design and utilization of epitope-based databases and predictive tools. Immunogenetics. 2010 Apr; 62(4):185-96. Salimi N, Fleri W, Peters B, Sette A. PMID: 20213141; PMCID: PMC2843836.
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Limitations of Ab initio predictions of peptide binding to MHC class II molecules. PLoS One. 2010 Feb 17; 5(2):e9272. Zhang H, Wang P, Papangelopoulos N, Xu Y, Sette A, Bourne PE, Lund O, Ponomarenko J, Nielsen M, Peters B. PMID: 20174654; PMCID: PMC2822856.
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Five HLA-DP molecules frequently expressed in the worldwide human population share a common HLA supertypic binding specificity. J Immunol. 2010 Mar 01; 184(5):2492-503. Sidney J, Steen A, Moore C, Ngo S, Chung J, Peters B, Sette A. PMID: 20139279; PMCID: PMC2935290.
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Two kinetic patterns of epitope-specific CD8 T-cell responses following murine gammaherpesvirus 68 infection. J Virol. 2010 Mar; 84(6):2881-92. Freeman ML, Lanzer KG, Cookenham T, Peters B, Sidney J, Wu TT, Sun R, Woodland DL, Sette A, Blackman MA. PMID: 20053740; PMCID: PMC2826075.
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Definition of epitopes and antigens recognized by vaccinia specific immune responses: their conservation in variola virus sequences, and use as a model system to study complex pathogens. Vaccine. 2009 Dec 30; 27 Suppl 6:G21-6. Sette A, Grey H, Oseroff C, Peters B, Moutaftsi M, Crotty S, Assarsson E, Greenbaum J, Kim Y, Kolla R, Tscharke D, Koelle D, Johnson RP, Blum J, Head S, Sidney J. PMID: 20006135; PMCID: PMC2928716.
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A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease. PLoS Pathog. 2009 Dec; 5(12):e1000695. Kotturi MF, Botten J, Sidney J, Bui HH, Giancola L, Maybeno M, Babin J, Oseroff C, Pasquetto V, Greenbaum JA, Peters B, Ting J, Do D, Vang L, Alexander J, Grey H, Buchmeier MJ, Sette A. PMID: 20019801; PMCID: PMC2787016.
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Derivation of an amino acid similarity matrix for peptide: MHC binding and its application as a Bayesian prior. BMC Bioinformatics. 2009 Nov 30; 10:394. Kim Y, Sidney J, Pinilla C, Sette A, Peters B. PMID: 19948066; PMCID: PMC2790471.
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Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20365-70. Greenbaum JA, Kotturi MF, Kim Y, Oseroff C, Vaughan K, Salimi N, Vita R, Ponomarenko J, Scheuermann RH, Sette A, Peters B. PMID: 19918065; PMCID: PMC2777968.
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The immune epitope database 2.0. Nucleic Acids Res. 2010 Jan; 38(Database issue):D854-62. Vita R, Zarebski L, Greenbaum JA, Emami H, Hoof I, Salimi N, Damle R, Sette A, Peters B. PMID: 19906713; PMCID: PMC2808938.
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Universal influenza DNA vaccine encoding conserved CD4+ T cell epitopes protects against lethal viral challenge in HLA-DR transgenic mice. Vaccine. 2010 Jan 08; 28(3):664-72. Alexander J, Bilsel P, del Guercio MF, Stewart S, Marinkovic-Petrovic A, Southwood S, Crimi C, Vang L, Walker L, Ishioka G, Chitnis V, Sette A, Assarsson E, Hannaman D, Botten J, Newman MJ. PMID: 19895924; PMCID: PMC3364000.
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The smallpox vaccine induces an early neutralizing IgM response. Vaccine. 2009 Dec 10; 28(1):140-7. Moyron-Quiroz JE, McCausland MM, Kageyama R, Sette A, Crotty S. PMID: 19822230; PMCID: PMC2788018.
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Design and preclinical development of a recombinant protein and DNA plasmid mixed format vaccine to deliver HIV-derived T-lymphocyte epitopes. Vaccine. 2009 Nov 23; 27(50):7087-95. Walker LE, Vang L, Shen X, Livingston BD, Post P, Sette A, Godin CS, Newman MJ. PMID: 19786132; PMCID: PMC2783266.
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Classification of the universe of immune epitope literature: representation and knowledge gaps. PLoS One. 2009 Sep 14; 4(9):e6948. Davies V, Vaughan K, Damle R, Peters B, Sette A. PMID: 19774228; PMCID: PMC2747625.
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Quantitating T cell cross-reactivity for unrelated peptide antigens. J Immunol. 2009 Oct 01; 183(7):4337-45. Ishizuka J, Grebe K, Shenderov E, Peters B, Chen Q, Peng Y, Wang L, Dong T, Pasquetto V, Oseroff C, Sidney J, Hickman H, Cerundolo V, Sette A, Bennink JR, McMichael A, Yewdell JW. PMID: 19734234; PMCID: PMC2762195.
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Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. J Clin Immunol. 2010 Jan; 30(1):157-66. Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A, Newman LS, Drake WP. PMID: 19536643; PMCID: PMC2821522.
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Of mice and humans: how good are HLA transgenic mice as a model of human immune responses? Immunome Res. 2009 Jun 17; 5:3. Kotturi MF, Assarsson E, Peters B, Grey H, Oseroff C, Pasquetto V, Sette A. PMID: 19534819; PMCID: PMC2702351.
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Cellular immune response to cryptic epitopes during therapeutic gene transfer. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10770-4. Li C, Goudy K, Hirsch M, Asokan A, Fan Y, Alexander J, Sun J, Monahan P, Seiber D, Sidney J, Sette A, Tisch R, Frelinger J, Samulski RJ. PMID: 19541644; PMCID: PMC2705599.
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Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. J Immunol. 2009 Jun 15; 182(12):7763-75. Loffredo JT, Sidney J, Bean AT, Beal DR, Bardet W, Wahl A, Hawkins OE, Piaskowski S, Wilson NA, Hildebrand WH, Watkins DI, Sette A. PMID: 19494300; PMCID: PMC2701622.
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Diverse recognition of conserved orthopoxvirus CD8+ T cell epitopes in vaccinated rhesus macaques. Vaccine. 2009 Aug 06; 27(36):4990-5000. Walsh SR, Gillis J, Peters B, Mothé BR, Sidney J, Sette A, Johnson RP. PMID: 19531389; PMCID: PMC2765250.
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A protective role for dengue virus-specific CD8+ T cells. J Immunol. 2009 Apr 15; 182(8):4865-73. Yauch LE, Zellweger RM, Kotturi MF, Qutubuddin A, Sidney J, Peters B, Prestwood TR, Sette A, Shresta S. PMID: 19342665; PMCID: PMC2674070.
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Intestinal T cell responses to gluten peptides are largely heterogeneous: implications for a peptide-based therapy in celiac disease. J Immunol. 2009 Apr 01; 182(7):4158-66. Camarca A, Anderson RP, Mamone G, Fierro O, Facchiano A, Costantini S, Zanzi D, Sidney J, Auricchio S, Sette A, Troncone R, Gianfrani C. PMID: 19299713; PMCID: PMC3306175.
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Herpes simplex virus type 2 tegument proteins contain subdominant T-cell epitopes detectable in BALB/c mice after DNA immunization and infection. J Gen Virol. 2009 May; 90(Pt 5):1153-1163. Muller WJ, Dong L, Vilalta A, Byrd B, Wilhelm KM, McClurkan CL, Margalith M, Liu C, Kaslow D, Sidney J, Sette A, Koelle DM. PMID: 19264627; PMCID: PMC2675279.
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Correlates of protection efficacy induced by vaccinia virus-specific CD8+ T-cell epitopes in the murine intranasal challenge model. Eur J Immunol. 2009 Mar; 39(3):717-22. Moutaftsi M, Salek-Ardakani S, Croft M, Peters B, Sidney J, Grey H, Sette A. PMID: 19224639; PMCID: PMC2759087.
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Preferential use of B7.2 and not B7.1 in priming of vaccinia virus-specific CD8 T cells. J Immunol. 2009 Mar 01; 182(5):2909-18. Salek-Ardakani S, Arens R, Flynn R, Sette A, Schoenberger SP, Croft M. PMID: 19234186; PMCID: PMC2707928.
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High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. J Immunol. 2008 Dec 15; 181(12):8215-25. Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, Dowd KA, Clute S, Wang C, Korman A, Sette A, Sidney J, Pardoll DM, Cox AL. PMID: 19050238; PMCID: PMC2773824.
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ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinformatics. 2008 Dec 02; 9:514. Ponomarenko J, Bui HH, Li W, Fusseder N, Bourne PE, Sette A, Peters B. PMID: 19055730; PMCID: PMC2607291.
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OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol. 2008 Dec 01; 181(11):7969-76. Salek-Ardakani S, Moutaftsi M, Crotty S, Sette A, Croft M. PMID: 19017988; PMCID: PMC2729132.
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NetMHCpan, a method for MHC class I binding prediction beyond humans. Immunogenetics. 2009 Jan; 61(1):1-13. Hoof I, Peters B, Sidney J, Pedersen LE, Sette A, Lund O, Buus S, Nielsen M. PMID: 19002680; PMCID: PMC3319061.
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Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects. J Immunol. 2008 Nov 01; 181(9):6604-15. Kim M, Taylor J, Sidney J, Mikloska Z, Bodsworth N, Lagios K, Dunckley H, Byth-Wilson K, Denis M, Finlayson R, Khanna R, Sette A, Cunningham AL. PMID: 18941251; PMCID: PMC3312789.
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Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire. J Immunol. 2008 Nov 01; 181(9):6435-46. Wölfl M, Rutebemberwa A, Mosbruger T, Mao Q, Li HM, Netski D, Ray SC, Pardoll D, Sidney J, Sette A, Allen T, Kuntzen T, Kavanagh DG, Kuball J, Greenberg PD, Cox AL. PMID: 18941234; PMCID: PMC2742502.
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Immunomic analysis of the repertoire of T-cell specificities for influenza A virus in humans. J Virol. 2008 Dec; 82(24):12241-51. Assarsson E, Bui HH, Sidney J, Zhang Q, Glenn J, Oseroff C, Mbawuike IN, Alexander J, Newman MJ, Grey H, Sette A. PMID: 18842709; PMCID: PMC2593359.
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Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. J Virol. 2008 Dec; 82(23):11734-41. Dow C, Oseroff C, Peters B, Nance-Sotelo C, Sidney J, Buchmeier M, Sette A, Mothé BR. PMID: 18829752; PMCID: PMC2583689.
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HLA Class I-T cell epitopes from trans-sialidase proteins reveal functionally distinct subsets of CD8+ T cells in chronic Chagas disease. PLoS Negl Trop Dis. 2008; 2(9):e288. Alvarez MG, Postan M, Weatherly DB, Albareda MC, Sidney J, Sette A, Olivera C, Armenti AH, Tarleton RL, Laucella SA. PMID: 18846233; PMCID: PMC2565697.
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Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J Immunol. 2008 Aug 01; 181(3):2124-33. Kotturi MF, Scott I, Wolfe T, Peters B, Sidney J, Cheroutre H, von Herrath MG, Buchmeier MJ, Grey H, Sette A. PMID: 18641351; PMCID: PMC3319690.
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Quantitative predictions of peptide binding to any HLA-DR molecule of known sequence: NetMHCIIpan. PLoS Comput Biol. 2008 Jul 04; 4(7):e1000107. Nielsen M, Lundegaard C, Blicher T, Peters B, Sette A, Justesen S, Buus S, Lund O. PMID: 18604266; PMCID: PMC2430535.
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Comprehensive analysis of T cell epitope discovery strategies using 17DD yellow fever virus structural proteins and BALB/c (H2d) mice model. Virology. 2008 Aug 15; 378(1):105-17. Maciel M, Kellathur SN, Chikhlikar P, Dhalia R, Sidney J, Sette A, August TJ, Marques ET. PMID: 18579176; PMCID: PMC2615555.
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A detailed analysis of the murine TAP transporter substrate specificity. PLoS One. 2008 Jun 11; 3(6):e2402. Burgevin A, Saveanu L, Kim Y, Barilleau E, Kotturi M, Sette A, van Endert P, Peters B. PMID: 18545702; PMCID: PMC2408963.
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Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve. J Immunol. 2008 Jun 01; 180(11):7193-202. Oseroff C, Peters B, Pasquetto V, Moutaftsi M, Sidney J, Panchanathan V, Tscharke DC, Maillere B, Grey H, Sette A. PMID: 18490718; PMCID: PMC2533852.
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Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity. 2008 Jun; 28(6):847-58. Sette A, Moutaftsi M, Moyron-Quiroz J, McCausland MM, Davies DH, Johnston RJ, Peters B, Rafii-El-Idrissi Benhnia M, Hoffmann J, Su HP, Singh K, Garboczi DN, Head S, Grey H, Felgner PL, Crotty S. PMID: 18549802; PMCID: PMC2504733.
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Immune epitope database analysis resource (IEDB-AR). Nucleic Acids Res. 2008 Jul 01; 36(Web Server issue):W513-8. Zhang Q, Wang P, Kim Y, Haste-Andersen P, Beaver J, Bourne PE, Bui HH, Buus S, Frankild S, Greenbaum J, Lund O, Lundegaard C, Nielsen M, Ponomarenko J, Sette A, Zhu Z, Peters B. PMID: 18515843; PMCID: PMC2447801.
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Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response. J Immunol. 2008 May 15; 180(10):6472-6. Arens R, Wang P, Sidney J, Loewendorf A, Sette A, Schoenberger SP, Peters B, Benedict CA. PMID: 18453564; PMCID: PMC2587066.
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A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput Biol. 2008 Apr 04; 4(4):e1000048. Wang P, Sidney J, Dow C, Mothé B, Sette A, Peters B. PMID: 18389056; PMCID: PMC2267221.
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Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol. 2008 Jun; 82(11):5594-605. Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TM. PMID: 18385228; PMCID: PMC2395179.
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Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques. J Virol. 2008 Jun; 82(11):5245-54. Maness NJ, Yant LJ, Chung C, Loffredo JT, Friedrich TC, Piaskowski SM, Furlott J, May GE, Soma T, León EJ, Wilson NA, Piontkivska H, Hughes AL, Sidney J, Sette A, Watkins DI. PMID: 18385251; PMCID: PMC2395202.
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Analysis of the binding of gluten T-cell epitopes to various human leukocyte antigen class II molecules. Hum Immunol. 2008 Feb; 69(2):94-100. Bergseng E, Sidney J, Sette A, Sollid LM. PMID: 18361933.
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Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2140-5. Assarsson E, Greenbaum JA, Sundström M, Schaffer L, Hammond JA, Pasquetto V, Oseroff C, Hendrickson RC, Lefkowitz EJ, Tscharke DC, Sidney J, Grey HM, Head SR, Peters B, Sette A. PMID: 18245380; PMCID: PMC2542872.
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Analysis of epitope information related to Bacillus anthracis and Clostridium botulinum. Expert Rev Vaccines. 2008 Feb; 7(1):55-74. Zarebski LM, Vaughan K, Sidney J, Peters B, Grey H, Janda KD, Casadevall A, Sette A. PMID: 18251694; PMCID: PMC3319117.
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Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. J Virol. 2008 Apr; 82(7):3751-68. Benhnia MR, McCausland MM, Su HP, Singh K, Hoffmann J, Davies DH, Felgner PL, Head S, Sette A, Garboczi DN, Crotty S. PMID: 18234801; PMCID: PMC2268460.
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Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries. Immunome Res. 2008 Jan 25; 4:2. Sidney J, Assarsson E, Moore C, Ngo S, Pinilla C, Sette A, Peters B. PMID: 18221540; PMCID: PMC2248166.
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HLA class I supertypes: a revised and updated classification. BMC Immunol. 2008 Jan 22; 9:1. Sidney J, Peters B, Frahm N, Brander C, Sette A. PMID: 18211710; PMCID: PMC2245908.
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Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Tuberculosis (Edinb). 2008 Jul; 88(4):366-70. Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. PMID: 18068490; PMCID: PMC2504685.
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An analysis of the epitope knowledge related to Mycobacteria. Immunome Res. 2007 Dec 14; 3:10. Blythe MJ, Zhang Q, Vaughan K, de Castro R, Salimi N, Bui HH, Lewinsohn DM, Ernst JD, Peters B, Sette A. PMID: 18081934; PMCID: PMC2228276.
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Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Nat Med. 2007 Dec; 13(12):1431-9. Rawson PM, Molette C, Videtta M, Altieri L, Franceschini D, Donato T, Finocchi L, Propato A, Paroli M, Meloni F, Mastroianni CM, d'Ettorre G, Sidney J, Sette A, Barnaba V. PMID: 18026114.
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CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation. PLoS One. 2007 Nov 14; 2(11):e1152. Loffredo JT, Friedrich TC, León EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontkivska H, Hughes AL, Sette A, Watkins DI. PMID: 18000532; PMCID: PMC2062500.
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AIDS virus specific CD8+ T lymphocytes against an immunodominant cryptic epitope select for viral escape. J Exp Med. 2007 Oct 29; 204(11):2505-12. Maness NJ, Valentine LE, May GE, Reed J, Piaskowski SM, Soma T, Furlott J, Rakasz EG, Friedrich TC, Price DA, Gostick E, Hughes AL, Sidney J, Sette A, Wilson NA, Watkins DI. PMID: 17954573; PMCID: PMC2118485.
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Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections. J Virol. 2008 Jan; 82(1):435-50. Depla E, Van der Aa A, Livingston BD, Crimi C, Allosery K, De Brabandere V, Krakover J, Murthy S, Huang M, Power S, Babé L, Dahlberg C, McKinney D, Sette A, Southwood S, Philip R, Newman MJ, Meheus L. PMID: 17942551; PMCID: PMC2224390.
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Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines. BMC Bioinformatics. 2007 Sep 26; 8:361. Bui HH, Sidney J, Li W, Fusseder N, Sette A. PMID: 17897458; PMCID: PMC2233646.
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Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. PLoS Pathog. 2007 Sep 21; 3(9):1240-9. Lewinsohn DA, Winata E, Swarbrick GM, Tanner KE, Cook MS, Null MD, Cansler ME, Sette A, Sidney J, Lewinsohn DM. PMID: 17892322; PMCID: PMC2323292.
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Extensive HLA class I allele promiscuity among viral CTL epitopes. Eur J Immunol. 2007 Sep; 37(9):2419-33. Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, Sango K, Brown NV, Pae E, Zaman MT, Bihl F, Khatri A, John M, Mallal S, Marincola FM, Walker BD, Sette A, Heckerman D, Korber BT, Brander C. PMID: 17705138; PMCID: PMC2628559.
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NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequence. PLoS One. 2007 Aug 29; 2(8):e796. Nielsen M, Lundegaard C, Blicher T, Lamberth K, Harndahl M, Justesen S, Røder G, Peters B, Sette A, Lund O, Buus S. PMID: 17726526; PMCID: PMC1949492.
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Automating document classification for the Immune Epitope Database. BMC Bioinformatics. 2007 Jul 26; 8:269. Wang P, Morgan AA, Zhang Q, Sette A, Peters B. PMID: 17655769; PMCID: PMC1965490.
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Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes. J Immunol. 2007 Jul 15; 179(2):1058-67. Mothé BR, Stewart BS, Oseroff C, Bui HH, Stogiera S, Garcia Z, Dow C, Rodriguez-Carreno MP, Kotturi M, Pasquetto V, Botten J, Crotty S, Janssen E, Buchmeier MJ, Sette A. PMID: 17617598.
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A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection. J Immunol. 2007 Jun 15; 178(12):7890-901. Assarsson E, Sidney J, Oseroff C, Pasquetto V, Bui HH, Frahm N, Brander C, Peters B, Grey H, Sette A. PMID: 17548627.
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Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol. 2007 Jun 01; 178(11):6814-20. Moutaftsi M, Bui HH, Peters B, Sidney J, Salek-Ardakani S, Oseroff C, Pasquetto V, Crotty S, Croft M, Lefkowitz EJ, Grey H, Sette A. PMID: 17513729.
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Integrating epitope data into the emerging web of biomedical knowledge resources. Nat Rev Immunol. 2007 Jun; 7(6):485-90. Peters B, Sette A. PMID: 17479127; PMCID: PMC7097317.
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A single minor histocompatibility antigen encoded by UGT2B17 and presented by human leukocyte antigen-A*2902 and -B*4403. Transplantation. 2007 May 15; 83(9):1242-8. Terakura S, Murata M, Warren EH, Sette A, Sidney J, Naoe T, Riddell SR. PMID: 17496542.
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Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflammation in juvenile idiopathic arthritis. Arthritis Rheum. 2007 May; 56(5):1648-57. Massa M, Passalia M, Manzoni SM, Campanelli R, Ciardelli L, Yung GP, Kamphuis S, Pistorio A, Meli V, Sette A, Prakken B, Martini A, Albani S. PMID: 17469159.
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Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools. J Mol Recognit. 2007 Mar-Apr; 20(2):75-82. Greenbaum JA, Andersen PH, Blythe M, Bui HH, Cachau RE, Crowe J, Davies M, Kolaskar AS, Lund O, Morrison S, Mumey B, Ofran Y, Pellequer JL, Pinilla C, Ponomarenko JV, Raghava GP, van Regenmortel MH, Roggen EL, Sette A, Schlessinger A, Sollner J, Zand M, Peters B. PMID: 17205610.
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The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol. 2007 May; 81(10):4928-40. Kotturi MF, Peters B, Buendia-Laysa F, Sidney J, Oseroff C, Botten J, Grey H, Buchmeier MJ, Sette A. PMID: 17329346; PMCID: PMC1900207.
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Protein sequence database for pathogenic arenaviruses. Immunome Res. 2007 Feb 08; 3:1. Bui HH, Botten J, Fusseder N, Pasquetto V, Mothe B, Buchmeier MJ, Sette A. PMID: 17288609; PMCID: PMC1803765.
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Ab and T cell epitopes of influenza A virus, knowledge and opportunities. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):246-51. Bui HH, Peters B, Assarsson E, Mbawuike I, Sette A. PMID: 17200302; PMCID: PMC1765443.
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HLA-A2-restricted protection against lethal lymphocytic choriomeningitis. J Virol. 2007 Mar; 81(5):2307-17. Botten J, Whitton JL, Barrowman P, Sidney J, Whitmire JK, Alexander J, Ting JP, Bui HH, Sette A, Buchmeier MJ. PMID: 17166907; PMCID: PMC1865925.
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Identification of novel consensus CD4 T-cell epitopes from clade B HIV-1 whole genome that are frequently recognized by HIV-1 infected patients. AIDS. 2006 Nov 28; 20(18):2263-73. Fonseca SG, Coutinho-Silva A, Fonseca LA, Segurado AC, Moraes SL, Rodrigues H, Hammer J, Kallás EG, Sidney J, Sette A, Kalil J, Cunha-Neto E. PMID: 17117012.
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Immune epitope mapping in the post-genomic era: lessons for vaccine development. Curr Opin Immunol. 2007 Feb; 19(1):106-10. Sette A, Peters B. PMID: 17113275.
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Immunogenic HLA-B7-restricted peptides of hTRT. Int Immunol. 2006 Dec; 18(12):1707-18. Cortez-Gonzalez X, Sidney J, Adotevi O, Sette A, Millard F, Lemonnier F, Langlade-Demoyen P, Zanetti M. PMID: 17077179.
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Novel pan-DR-binding T cell epitopes of adenovirus induce pro-inflammatory cytokines and chemokines in healthy donors. Int Immunol. 2006 Nov; 18(11):1521-9. Haveman LM, Bierings M, Legger E, Klein MR, de Jager W, Otten HG, Albani S, Kuis W, Sette A, Prakken BJ. PMID: 16954167.
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Identification of protective Lassa virus epitopes that are restricted by HLA-A2. J Virol. 2006 Sep; 80(17):8351-61. Botten J, Alexander J, Pasquetto V, Sidney J, Barrowman P, Ting J, Peters B, Southwood S, Stewart B, Rodriguez-Carreno MP, Mothe B, Whitton JL, Sette A, Buchmeier MJ. PMID: 16912286; PMCID: PMC1563871.
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CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog. 2006 Aug; 2(8):e77. Martin DL, Weatherly DB, Laucella SA, Cabinian MA, Crim MT, Sullivan S, Heiges M, Craven SH, Rosenberg CS, Collins MH, Sette A, Postan M, Tarleton RL. PMID: 16879036; PMCID: PMC1526708.
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Curation of complex, context-dependent immunological data. BMC Bioinformatics. 2006 Jul 12; 7:341. Vita R, Vaughan K, Zarebski L, Salimi N, Fleri W, Grey H, Sathiamurthy M, Mokili J, Bui HH, Bourne PE, Ponomarenko J, de Castro R, Chan RK, Sidney J, Wilson SS, Stewart S, Way S, Peters B, Sette A. PMID: 16836764; PMCID: PMC1534061.
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Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice. J Virol. 2006 Jul; 80(13):6318-23. Tscharke DC, Woo WP, Sakala IG, Sidney J, Sette A, Moss DJ, Bennink JR, Karupiah G, Yewdell JW. PMID: 16775319; PMCID: PMC1488955.
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Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules. Immunogenetics. 2006 Jul; 58(7):559-70. Sidney J, Asabe S, Peters B, Purton KA, Chung J, Pencille TJ, Purcell R, Walker CM, Chisari FV, Sette A. PMID: 16791621.
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T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. Int Immunol. 2006 Jul; 18(7):1179-88. Lichterfeld M, Williams KL, Mui SK, Shah SS, Mothe BR, Sette A, Kim A, Johnston MN, Burgett N, Frahm N, Cohen D, Brander C, Rosenberg ES, Walker BD, Altfeld M, Yu XG. PMID: 16772368.
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A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol. 2006 Jul; 24(7):817-9. Moutaftsi M, Peters B, Pasquetto V, Tscharke DC, Sidney J, Bui HH, Grey H, Sette A. PMID: 16767078.
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A community resource benchmarking predictions of peptide binding to MHC-I molecules. PLoS Comput Biol. 2006 Jun 09; 2(6):e65. Peters B, Bui HH, Frankild S, Nielson M, Lundegaard C, Kostem E, Basch D, Lamberth K, Harndahl M, Fleri W, Wilson SS, Sidney J, Lund O, Buus S, Sette A. PMID: 16789818; PMCID: PMC1475712.
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Immunogenicity of a recombinant protein containing the Plasmodium vivax vaccine candidate MSP1(19) and two human CD4+ T-cell epitopes administered to non-human primates (Callithrix jacchus jacchus). Microbes Infect. 2006 Jul; 8(8):2130-7. Rosa DS, Iwai LK, Tzelepis F, Bargieri DY, Medeiros MA, Soares IS, Sidney J, Sette A, Kalil J, Mello LE, Cunha-Neto E, Rodrigues MM. PMID: 16797207.
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Mapping immune responses to mRBP-3 1-16 peptide with altered peptide ligands. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2027-35. Guyver CJ, Copland DA, Calder CJ, Sette A, Sidney J, Dick AD, Nicholson LB. PMID: 16639012.
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Improving MHC binding peptide prediction by incorporating binding data of auxiliary MHC molecules. Bioinformatics. 2006 Jul 01; 22(13):1648-55. Zhu S, Udaka K, Sidney J, Sette A, Aoki-Kinoshita KF, Mamitsuka H. PMID: 16613909.
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Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses. J Immunol. 2006 Apr 01; 176(7):4094-101. Bihl F, Frahm N, Di Giammarino L, Sidney J, John M, Yusim K, Woodberry T, Sango K, Hewitt HS, Henry L, Linde CH, Chisholm JV, Zaman TM, Pae E, Mallal S, Walker BD, Sette A, Korber BT, Heckerman D, Brander C. PMID: 16547245.
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Predicting population coverage of T-cell epitope-based diagnostics and vaccines. BMC Bioinformatics. 2006 Mar 17; 7:153. Bui HH, Sidney J, Dinh K, Southwood S, Newman MJ, Sette A. PMID: 16545123; PMCID: PMC1513259.
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Immunodominance of poxviral-specific CTL in a human trial of recombinant-modified vaccinia Ankara. J Immunol. 2005 Dec 15; 175(12):8431-7. Smith CL, Mirza F, Pasquetto V, Tscharke DC, Palmowski MJ, Dunbar PR, Sette A, Harris AL, Cerundolo V. PMID: 16339586.
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The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239. J Immunol. 2005 Nov 01; 175(9):5986-97. Loffredo JT, Sidney J, Piaskowski S, Szymanski A, Furlott J, Rudersdorf R, Reed J, Peters B, Hickman-Miller HD, Bardet W, Rehrauer WM, O'Connor DH, Wilson NA, Hildebrand WH, Sette A, Watkins DI. PMID: 16237093.
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HLA-A*0201, HLA-A*1101, and HLA-B*0702 transgenic mice recognize numerous poxvirus determinants from a wide variety of viral gene products. J Immunol. 2005 Oct 15; 175(8):5504-15. Pasquetto V, Bui HH, Giannino R, Banh C, Mirza F, Sidney J, Oseroff C, Tscharke DC, Irvine K, Bennink JR, Peters B, Southwood S, Cerundolo V, Grey H, Yewdell JW, Sette A. PMID: 16210659.
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An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities. Immunome Res. 2005 Sep 20; 1(1):2. Sathiamurthy M, Peters B, Bui HH, Sidney J, Mokili J, Wilson SS, Fleri W, McGuinness DL, Bourne PE, Sette A. PMID: 16305755; PMCID: PMC1287064.
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HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13980-5. Oseroff C, Kos F, Bui HH, Peters B, Pasquetto V, Glenn J, Palmore T, Sidney J, Tscharke DC, Bennink JR, Southwood S, Grey HM, Yewdell JW, Sette A. PMID: 16172378; PMCID: PMC1236582.
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Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol. 2005 Sep 15; 175(6):3603-13. Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. PMID: 16148104.
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Tumor-associated carbohydrate antigens: a possible avenue for cancer prevention. Immunol Cell Biol. 2005 Aug; 83(4):440-8. Xu Y, Sette A, Sidney J, Gendler SJ, Franco A. PMID: 16033540.
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Classification of A1- and A24-supertype molecules by analysis of their MHC-peptide binding repertoires. Immunogenetics. 2005 Jul; 57(6):393-408. Sidney J, Southwood S, Sette A. PMID: 16003466.
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Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis. Lancet. 2005 Jul 2-8; 366(9479):50-6. Kamphuis S, Kuis W, de Jager W, Teklenburg G, Massa M, Gordon G, Boerhof M, Rijkers GT, Uiterwaal CS, Otten HG, Sette A, Albani S, Prakken BJ. PMID: 15993233.
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Cellular immune selection with hepatitis C virus persistence in humans. J Exp Med. 2005 Jun 06; 201(11):1741-52. Cox AL, Mosbruger T, Mao Q, Liu Z, Wang XH, Yang HC, Sidney J, Sette A, Pardoll D, Thomas DL, Ray SC. PMID: 15939790; PMCID: PMC2213263.
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Generating quantitative models describing the sequence specificity of biological processes with the stabilized matrix method. BMC Bioinformatics. 2005 May 31; 6:132. Peters B, Sette A. PMID: 15927070; PMCID: PMC1173087.
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The design and implementation of the immune epitope database and analysis resource. Immunogenetics. 2005 Jun; 57(5):326-36. Peters B, Sidney J, Bourne P, Bui HH, Buus S, Doh G, Fleri W, Kronenberg M, Kubo R, Lund O, Nemazee D, Ponomarenko JV, Sathiamurthy M, Schoenberger SP, Stewart S, Surko P, Way S, Wilson S, Sette A. PMID: 15895191; PMCID: PMC4780685.
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Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics. 2005 Jun; 57(5):304-14. Bui HH, Sidney J, Peters B, Sathiamurthy M, Sinichi A, Purton KA, Mothé BR, Chisari FV, Watkins DI, Sette A. PMID: 15868141.
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Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag77-85. Eur J Immunol. 2005 May; 35(5):1428-37. Boggiano C, Moya R, Pinilla C, Bihl F, Brander C, Sidney J, Sette A, Blondelle SE. PMID: 15789356.
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A CD8+ T cell heptaepitope minigene vaccine induces protective immunity against Chlamydia pneumoniae. J Immunol. 2005 May 01; 174(9):5729-39. Pinchuk I, Starcher BC, Livingston B, Tvninnereim A, Wu S, Appella E, Sidney J, Sette A, Wizel B. PMID: 15843575.
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The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design. J Virol. 2005 Apr; 79(8):5000-5. Altfeld M, Allen TM, Kalife ET, Frahm N, Addo MM, Mothe BR, Rathod A, Reyor LL, Harlow J, Yu XG, Perkins B, Robinson LK, Sidney J, Alter G, Lichterfeld M, Sette A, Rosenberg ES, Goulder PJ, Brander C, Walker BD. PMID: 15795285; PMCID: PMC1069570.
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Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect. 2005 Apr; 7(4):688-97. Fonseca SG, Moins-Teisserenc H, Clave E, Ianni B, Nunes VL, Mady C, Iwai LK, Sette A, Sidney J, Marin ML, Goldberg AC, Guilherme L, Charron D, Toubert A, Kalil J, Cunha-Neto E. PMID: 15848276.
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Rationally engineered therapeutic proteins with reduced immunogenicity. J Immunol. 2005 Mar 15; 174(6):3187-96. Tangri S, Mothé BR, Eisenbraun J, Sidney J, Southwood S, Briggs K, Zinckgraf J, Bilsel P, Newman M, Chesnut R, Licalsi C, Sette A. PMID: 15749848.
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Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity. Immunogenetics. 2005 Apr; 57(1-2):53-68. Sette A, Sidney J, Bui HH, del Guercio MF, Alexander J, Loffredo J, Watkins DI, Mothé BR. PMID: 15747117.
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The immune epitope database and analysis resource: from vision to blueprint. PLoS Biol. 2005 Mar; 3(3):e91. Peters B, Sidney J, Bourne P, Bui HH, Buus S, Doh G, Fleri W, Kronenberg M, Kubo R, Lund O, Nemazee D, Ponomarenko JV, Sathiamurthy M, Schoenberger S, Stewart S, Surko P, Way S, Wilson S, Sette A. PMID: 15760272; PMCID: PMC1065705.
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A roadmap for the immunomics of category A-C pathogens. Immunity. 2005 Feb; 22(2):155-61. Sette A, Fleri W, Peters B, Sathiamurthy M, Bui HH, Wilson S. PMID: 15773067.
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Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J Exp Med. 2005 Jan 03; 201(1):95-104. Tscharke DC, Karupiah G, Zhou J, Palmore T, Irvine KR, Haeryfar SM, Williams S, Sidney J, Sette A, Bennink JR, Yewdell JW. PMID: 15623576; PMCID: PMC2212779.
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Cellular immune responses to the hepatitis B virus polymerase. J Immunol. 2004 Nov 01; 173(9):5863-71. Mizukoshi E, Sidney J, Livingston B, Ghany M, Hoofnagle JH, Sette A, Rehermann B. PMID: 15494540.
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Identification of seventeen new simian immunodeficiency virus-derived CD8+ T cell epitopes restricted by the high frequency molecule, Mamu-A*02, and potential escape from CTL recognition. J Immunol. 2004 Oct 15; 173(8):5064-76. Loffredo JT, Sidney J, Wojewoda C, Dodds E, Reynolds MR, Napoé G, Mothé BR, O'Connor DH, Wilson NA, Watkins DI, Sette A. PMID: 15470050.
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Recognition of variant HIV-1 epitopes from diverse viral subtypes by vaccine-induced CTL. J Immunol. 2004 Aug 01; 173(3):1941-50. McKinney DM, Skvoretz R, Livingston BD, Wilson CC, Anders M, Chesnut RW, Sette A, Essex M, Novitsky V, Newman MJ. PMID: 15265928.
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Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J Virol. 2004 Jul; 78(13):7069-78. Allen TM, Altfeld M, Yu XG, O'Sullivan KM, Lichterfeld M, Le Gall S, John M, Mothe BR, Lee PK, Kalife ET, Cohen DE, Freedberg KA, Strick DA, Johnston MN, Sette A, Rosenberg ES, Mallal SA, Goulder PJ, Brander C, Walker BD. PMID: 15194783; PMCID: PMC421658.
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Development of experimental carbohydrate-conjugate vaccines composed of Streptococcus pneumoniae capsular polysaccharides and the universal helper T-lymphocyte epitope (PADRE). Vaccine. 2004 Jun 23; 22(19):2362-7. Alexander J, del Guercio MF, Frame B, Maewal A, Sette A, Nahm MH, Newman MJ. PMID: 15193395.
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Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J Virol. 2004 May; 78(9):4463-77. Kaufmann DE, Bailey PM, Sidney J, Wagner B, Norris PJ, Johnston MN, Cosimi LA, Addo MM, Lichterfeld M, Altfeld M, Frahm N, Brander C, Sette A, Walker BD, Rosenberg ES. PMID: 15078927; PMCID: PMC387674.
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Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells. Blood. 2004 Aug 01; 104(3):752-9. Lou Q, Kelleher RJ, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH. PMID: 15054043.
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Improved immunogenicity of an immunodominant epitope of the HER-2/neu protooncogene by alterations of MHC contact residues. J Immunol. 2004 Mar 15; 172(6):3501-8. Vertuani S, Sette A, Sidney J, Southwood S, Fikes J, Keogh E, Lindencrona JA, Ishioka G, Levitskaya J, Kiessling R. PMID: 15004150.
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Reversion of CTL escape-variant immunodeficiency viruses in vivo. Nat Med. 2004 Mar; 10(3):275-81. Friedrich TC, Dodds EJ, Yant LJ, Vojnov L, Rudersdorf R, Cullen C, Evans DT, Desrosiers RC, Mothé BR, Sidney J, Sette A, Kunstman K, Wolinsky S, Piatak M, Lifson J, Hughes AL, Wilson N, O'Connor DH, Watkins DI. PMID: 14966520.
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Characterization of MHC- and TCR-binding residues of the myelin oligodendrocyte glycoprotein 38-51 peptide. Eur J Immunol. 2004 Jan; 34(1):165-73. Petersen TR, Bettelli E, Sidney J, Sette A, Kuchroo V, Bäckström BT. PMID: 14971042.
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Conserved hierarchy of helper T cell responses in a chimpanzee during primary and secondary hepatitis C virus infections. J Immunol. 2004 Jan 01; 172(1):483-92. Shoukry NH, Sidney J, Sette A, Walker CM. PMID: 14688358.
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The immune epitope database and analysis resource: from vision to blueprint. Genome Inform. 2004; 15(2):299. Sette A. PMID: 16312048.
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Simultaneous prediction of binding capacity for multiple molecules of the HLA B44 supertype. J Immunol. 2003 Dec 01; 171(11):5964-74. Sidney J, Southwood S, Pasquetto V, Sette A. PMID: 14634108.
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Development of a DNA vaccine designed to induce cytotoxic T lymphocyte responses to multiple conserved epitopes in HIV-1. J Immunol. 2003 Nov 15; 171(10):5611-23. Wilson CC, McKinney D, Anders M, MaWhinney S, Forster J, Crimi C, Southwood S, Sette A, Chesnut R, Newman MJ, Livingston BD. PMID: 14607970.
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Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation. Virology. 2003 Oct 10; 315(1):93-102. van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Sette A, Ahmed R. PMID: 14592762.
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Examining the independent binding assumption for binding of peptide epitopes to MHC-I molecules. Bioinformatics. 2003 Sep 22; 19(14):1765-72. Peters B, Tong W, Sidney J, Sette A, Weng Z. PMID: 14512347.
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Design of multi-epitope, analogue-based cancer vaccines. Expert Opin Biol Ther. 2003 Sep; 3(6):985-93. Fikes JD, Sette A. PMID: 12943457.
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In silico prediction of peptides binding to multiple HLA-DR molecules accurately identifies immunodominant epitopes from gp43 of Paracoccidioides brasiliensis frequently recognized in primary peripheral blood mononuclear cell responses from sensitized individuals. Mol Med. 2003 Sep-Dec; 9(9-12):209-19. Iwai LK, Yoshida M, Sidney J, Shikanai-Yasuda MA, Goldberg AC, Juliano MA, Hammer J, Juliano L, Sette A, Kalil J, Travassos LR, Cunha-Neto E. PMID: 15208742; PMCID: PMC1430984.
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Epitope-based vaccines: an update on epitope identification, vaccine design and delivery. Curr Opin Immunol. 2003 Aug; 15(4):461-70. Sette A, Fikes J. PMID: 12900280.
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Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9952-7. Doolan DL, Southwood S, Freilich DA, Sidney J, Graber NL, Shatney L, Bebris L, Florens L, Dobano C, Witney AA, Appella E, Hoffman SL, Yates JR, Carucci DJ, Sette A. PMID: 12886016; PMCID: PMC187898.
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Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J Immunol. 2003 Jul 15; 171(2):538-41. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. PMID: 12847215.
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Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5342-7. Maverakis E, Beech J, Stevens DB, Ametani A, Brossay L, van den Elzen P, Mendoza R, Thai Q, Macias LH, Ethell D, Campagnoni CW, Campagnoni AT, Sette A, Sercarz EE. PMID: 12707414; PMCID: PMC154347.
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Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope. J Immunol. 2003 Mar 01; 170(5):2719-26. Gianfrani C, Troncone R, Mugione P, Cosentini E, De Pascale M, Faruolo C, Senger S, Terrazzano G, Southwood S, Auricchio S, Sette A. PMID: 12594302.
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MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. Clin Cancer Res. 2003 Mar; 9(3):947-54. Tatsumi T, Kierstead LS, Ranieri E, Gesualdo L, Schena FP, Finke JH, Bukowski RM, Brusic V, Sidney J, Sette A, Logan TF, Kasamon YL, Slingluff CL, Kirkwood JM, Storkus WJ. PMID: 12631591.
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Class I molecules with similar peptide-binding specificities are the result of both common ancestry and convergent evolution. Immunogenetics. 2003 Mar; 54(12):830-41. Sette A, Sidney J, Livingston BD, Dzuris JL, Crimi C, Walker CM, Southwood S, Collins EJ, Hughes AL. PMID: 12671733.
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Derivation of HLA-B*0702 transgenic mice: functional CTL repertoire and recognition of human B*0702-restricted CTL epitopes. Hum Immunol. 2003 Feb; 64(2):211-23. Alexander J, Oseroff C, Sidney J, Sette A. PMID: 12559623.
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Normal tissue depresses while tumor tissue enhances human T cell responses in vivo to a novel self/tumor melanoma antigen, OA1. J Immunol. 2003 Feb 01; 170(3):1579-85. Touloukian CE, Leitner WW, Schnur RE, Robbins PF, Li Y, Southwood S, Sette A, Rosenberg SA, Restifo NP. PMID: 12538723; PMCID: PMC2241741.
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Early induction and maintenance of Env-specific T-helper cells following human immunodeficiency virus type 1 infection. J Virol. 2003 Feb; 77(4):2663-74. Malhotra U, Holte S, Zhu T, Delpit E, Huntsberry C, Sette A, Shankarappa R, Maenza J, Corey L, McElrath MJ. PMID: 12552005; PMCID: PMC141076.
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Diverse repertoire of HIV-1 p24-specific, IFN-gamma-producing CD4+ T cell clones following immune reconstitution on highly active antiretroviral therapy. J Immunol. 2003 Jan 15; 170(2):1106-16. Boritz E, Palmer BE, Livingston B, Sette A, Wilson CC. PMID: 12517980.
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Escape in one of two cytotoxic T-lymphocyte epitopes bound by a high-frequency major histocompatibility complex class I molecule, Mamu-A*02: a paradigm for virus evolution and persistence? J Virol. 2002 Nov; 76(22):11623-36. Vogel TU, Friedrich TC, O'Connor DH, Rehrauer W, Dodds EJ, Hickman H, Hildebrand W, Sidney J, Sette A, Hughes A, Horton H, Vielhuber K, Rudersdorf R, De Souza IP, Reynolds MR, Allen TM, Wilson N, Watkins DI. PMID: 12388723; PMCID: PMC136802.
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The HLA molecules DQA1*0501/B1*0201 and DQA1*0301/B1*0302 share an extensive overlap in peptide binding specificity. J Immunol. 2002 Nov 01; 169(9):5098-108. Sidney J, del Guercio MF, Southwood S, Sette A. PMID: 12391226.
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Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection. J Virol. 2002 Oct; 76(20):10507-11. Allen TM, Jing P, Calore B, Horton H, O'Connor DH, Hanke T, Piekarczyk M, Ruddersdorf R, Mothé BR, Emerson C, Wilson N, Lifson JD, Belyakov IM, Berzofsky JA, Wang C, Allison DB, Montefiori DC, Desrosiers RC, Wolinsky S, Kunstman KJ, Altman JD, Sette A, McMichael AJ, Watkins DI. PMID: 12239328; PMCID: PMC136573.
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Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J Virol. 2002 Sep; 76(17):8609-20. Kakimi K, Isogawa M, Chung J, Sette A, Chisari FV. PMID: 12163580; PMCID: PMC136410.
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Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen. J Immunol. 2002 Sep 01; 169(5):2524-35. Wizel B, Starcher BC, Samten B, Chroneos Z, Barnes PF, Dzuris J, Higashimoto Y, Appella E, Sette A. PMID: 12193722.
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Structural snapshot of aberrant antigen presentation linked to autoimmunity: the immunodominant epitope of MBP complexed with I-Au. Immunity. 2002 Jul; 17(1):83-94. He XL, Radu C, Sidney J, Sette A, Ward ES, Garcia KC. PMID: 12150894.
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Characterization of the peptide-binding specificity of Mamu-B*17 and identification of Mamu-B*17-restricted epitopes derived from simian immunodeficiency virus proteins. J Immunol. 2002 Jul 01; 169(1):210-9. Mothé BR, Sidney J, Dzuris JL, Liebl ME, Fuenger S, Watkins DI, Sette A. PMID: 12077247.
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A decaepitope polypeptide primes for multiple CD8+ IFN-gamma and Th lymphocyte responses: evaluation of multiepitope polypeptides as a mode for vaccine delivery. J Immunol. 2002 Jun 15; 168(12):6189-98. Alexander J, Oseroff C, Dahlberg C, Qin M, Ishioka G, Beebe M, Fikes J, Newman M, Chesnut RW, Morton PA, Fok K, Appella E, Sette A. PMID: 12055232.
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T-lymphocyte epitope identification and their use in vaccine development for HIV-1. Front Biosci. 2002 Jun 01; 7:d1503-15. Newman MJ, Livingston B, McKinney DM, Chesnut RW, Sette A. PMID: 12048179.
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A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes. J Immunol. 2002 Jun 01; 168(11):5499-506. Livingston B, Crimi C, Newman M, Higashimoto Y, Appella E, Sidney J, Sette A. PMID: 12023344.
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Minor structural changes in a mutated human melanoma antigen correspond to dramatically enhanced stimulation of a CD4+ tumor-infiltrating lymphocyte line. J Mol Biol. 2002 May 31; 319(2):449-61. Sundberg EJ, Sawicki MW, Southwood S, Andersen PS, Sette A, Mariuzza RA. PMID: 12051920.
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Epitope identification and vaccine design for cancer immunotherapy. Curr Opin Investig Drugs. 2002 Jan; 3(1):132-9. Sette A, Keogh E, Ishioka G, Sidney J, Tangri S, Livingston B, McKinney D, Newman M, Chesnut R, Fikes J. PMID: 12054064.
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Overcoming T cell tolerance to the hepatitis B virus surface antigen in hepatitis B virus-transgenic mice. J Immunol. 2001 Jan 15; 166(2):1389-97. Sette AD, Oseroff C, Sidney J, Alexander J, Chesnut RW, Kakimi K, Guidotti LG, Chisari FV. PMID: 11145724.
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