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Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy. J Immunother Cancer. 2026 Feb 04; 14(2). Marrocco R, Patel J, Medari R, Salu P, Lucero-Meza E, Maia C, Brunel S, Martsinkovskiy A, Sun S, Gulay K, Jaljuli M, Mose E, Lowy A, Benedict C, Hurtado de Mendoza T. PMID: 41638871; PMCID: PMC12927352.
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Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug. Proc Natl Acad Sci U S A. 2026 Jan 27; 123(4):e2511733123. Antonucci L, Watari K, Feng Y, Qi J, Zhu M, Wang T, Ng I, Vucic EA, Riahi I, Huang L, Hosseini M, Mose E, French R, Weitz J, Bar-Sagi D, Dawson DW, Sun B, Tiriac H, Xu J, Xu S, Lowy AM, Karin M. PMID: 41564125; PMCID: PMC12849708.
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Chronic pancreatitis patient-derived organoids reveal new paths to precision therapeutics. bioRxiv. 2025 Nov 14. Osorio-Vasquez V, Zhu J, Lumibao JC, Lande K, Peck KL, Stamp MK, Okhovat SR, Song H, Ogawa S, Kubota C, Pantazopoulou V, Dai Y, Rock A, Bottomley C, Thomas E, Hsu J, Morales AH, Fowler A, McGriff T, Evensen KG, Larsen S, Abdulla M, Greer P, Gibson J, Downes M, Evans R, Lowy AM, Whitcomb DC, Zou J, Molinolo A, Oh TG, White R, Bellin M, Tiriac H, Engle DD. PMID: 41279927; PMCID: PMC12633304.
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A Novel Adjuvant Chemoradiotherapy/Immunotherapy for Resected Biliary Cancer. JAMA Oncol. 2025 Sep 01; 11(9):1029-1030. Ben-Josef E, Lowy AM. PMID: 40638103.
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Experimental models of pancreas cancer: what has been the impact for precision medicine? J Clin Invest. 2025 Aug 15; 135(16). Pantazopoulou V, Kubota CS, Ogawa S, Gulay KCM, Lin X, Song H, Weitz JR, Tiriac H, Lowy AM, Engle DD. PMID: 40829173; PMCID: PMC12352895.
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ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC. Nat Chem Biol. 2026 Feb; 22(2):260-273. Tran NL, Jiang J, Ma M, Gadbois GE, Gulay KCM, Verano AL, Schiavon CR, Rebollo E, Zhou H, Huang CT, Murad R, Scott DA, Manor U, Bang AG, Tiriac H, Lowy AM, Wang ES, Ferguson FM. PMID: 40789946.
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer. Cancer Cell. 2025 Sep 08; 43(9):1677-1696.e15. Zhang Y, Ling L, Murad R, Maganti S, Manceau A, Hetrick HA, Neff M, Galapate CM, Grenier SF, Carrette F, Duong-Polk K, Bagchi A, Scott DA, Altman Y, Hope JL, Lowy AM, Bradley LM, Commisso C. PMID: 40712568; PMCID: PMC12313264.
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Evolving concepts in adjuvant/neoadjuvant therapy for resectable pancreas cancer. J Clin Invest. 2025 Jul 15; 135(14). Bryant JM, Ruffolo L, Soares K, Hoffe S, Lowy AM. PMID: 40662364; PMCID: PMC12259248.
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Author Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2025 Jul; 643(8071):E10. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner DA, Sun B, Karin M. PMID: 40533566; PMCID: PMC12240813.
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Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer. Nat Cancer. 2025 Jul; 6(7):1263-1282. Antonucci L, Li N, Duran A, Cobo I, Nicoletti C, Watari K, Nandi SP, Zhu F, Zhao Y, Riahi I, Tsuda M, Shah VM, Morgan T, Waugh T, Caputo L, Liu Y, Rundberg Nilsson A, Xian H, Todoric J, Gu L, Sanchez-Lopez E, Eibl G, Vucic EA, Krawczyk M, Xu Q, Lowy AM, Hatzivassiliou G, Roose-Girma M, Skowronska-Krawczyk D, Scott DA, Bar-Sagi D, Tamayo P, Wu Y, Sears RC, Glass CK, Alexandrov LB, Puri PL, Dawson DW, Hu Y, Diaz-Meco MT, Moscat J, Karin M. PMID: 40588523; PMCID: PMC12331375.
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Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer. bioRxiv. 2025 Jun 05. Dufresne S, Kuna RS, Wong K, Komarla A, Rock A, Rosada-Encarnación J, Shen C, Mondal P, Parham LR, Izidro Layng F, Peck KL, Fowler A, Lowy AM, Engle D, Tiriac H, Shaw R, Cosford N, Metallo C, Towers C. PMID: 40501952; PMCID: PMC12154929.
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Redirecting cytomegalovirus immunity against pancreas cancer for immunotherapy. bioRxiv. 2025 May 19. Marrocco R, Patel J, Medari R, Salu P, Lucero ME, Brunel S, Martsinkovskiy A, Sun S, Gulay K, Jaljuli M, Mose E, Lowy AM, Benedict CA, Hurtado de MT. PMID: 40475479; PMCID: PMC12139863.
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Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer. Nature. 2025 Jun; 642(8066):212-221. Pei G, Min J, Rajapakshe KI, Branchi V, Liu Y, Selvanesan BC, Thege F, Sadeghian D, Zhang D, Cho KS, Chu Y, Dai E, Han G, Li M, Yee C, Takahashi K, Garg B, Tiriac H, Bernard V, Semaan A, Grem JL, Caffrey TC, Burks JK, Lowy AM, Aguirre AJ, Grandgenett PM, Hollingsworth MA, Guerrero PA, Wang L, Maitra A. PMID: 40269162.
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Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma. J Pharmacol Exp Ther. 2025 May; 392(5):103573. Salmerón C, Tomás Bort E, Sriram K, Javadi-Paydar M, Smitham JE, Pham K, Grose RP, McCormick PJ, DiNardo A, Weitz J, Tiriac H, Lowy AM, Insel PA. PMID: 40288207.
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Correction to: Survival Outcomes Between Minimally Invasive and Open Gastrectomy in Early and Locally Advanced Gastric Adenocarcinoma in a Western Center. J Gastrointest Cancer. 2025 Apr 02; 56(1):91. Kalavacherla S, Neel N, Jagadeesh V, Bouvet M, Lowy A, Horgan S, Mehtsun WT, Kelly KJ. PMID: 40175861.
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MICAL2 Promotes Pancreatic Cancer Growth and Metastasis. Cancer Res. 2025 Mar 14; 85(6):1049-1063. Garg B, Khan S, Courelli AS, Panneerpandian P, Sheik Pran Babu D, Mose ES, Gulay KCM, Sharma S, Sood D, Wenzel AT, Martsinkovskiy A, Rajbhandari N, Patel J, Jaquish D, Esparza E, Jaque K, Aggarwal N, Lambies G, D'Ippolito A, Austgen K, Johnston B, Orlando DA, Jang GH, Gallinger S, Goodfellow E, Brodt P, Commisso C, Tamayo P, Mesirov JP, Tiriac H, Lowy AM. PMID: 39745352; PMCID: PMC11907191.
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Incorporating Circulating Tumor DNA Testing Into Clinical Trials: A Position Paper by the National Cancer Institute GI Oncology Circulating Tumor DNA Working Group. JCO Precis Oncol. 2025 Mar; 9:e2400489. Rajdev L, King GG, Lieu CH, Cohen SA, Pant S, Uboha NV, Deming D, Malla M, Kasi A, Klute K, Spencer KR, Dasari A, Morris VK, Botta G, Lowy AM, O'Hara MH, Eads J, King D, Shah MA, Hong TS, Parikh A, Klempner SJ, Jabbour SK, Chawla A, Molena D, George TJ, Gibson MK, Allegra C, Goodman K, Eng C, Philip PA. PMID: 40048671; PMCID: PMC11893001.
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Survival Outcomes Between Minimally Invasive and Open Gastrectomy in Early and Locally Advanced Gastric Adenocarcinoma in a Western Center. J Gastrointest Cancer. 2025 Feb 20; 56(1):68. Kalavacherla S, Neel N, Jagadeesh V, Bouvet M, Lowy A, Horgan S, Kelly KJ, Mehtsun WT. PMID: 39979489.
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Defining a 'cells to society' research framework for appendiceal tumours. Nat Rev Cancer. 2025 Apr; 25(4):293-315. Holowatyj AN, Overman MJ, Votanopoulos KI, Lowy AM, Wagner P, Washington MK, Eng C, Foo WC, Goldberg RM, Hosseini M, Idrees K, Johnson DB, Shergill A, Ward E, Zachos NC, Shelton D, Appendix Cancer Pseudomyxoma Peritonei (ACPMP) Research Foundation. PMID: 39979656; PMCID: PMC12427072.
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Chemotherapy dose density is prognostic for overall survival in patients with resectable pancreas cancer: A landmark analysis of SWOG 1505. Cancer. 2025 Feb 15; 131(4):e35759. Patel SH, Colby S, Sohal D, Guthrie KA, Kachnic LA, Chiorean EG, Lowy AM, Rocha FG, Hochster HS, Philip PA, Ahmad SA. PMID: 39932777; PMCID: PMC11812894.
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Macropinocytosis controls metabolic stress-driven CAF subtype identity in pancreatic cancer. bioRxiv. 2024 Dec 05. Zhang Y, Ling L, Maganti S, Hope JL, Galapate CM, Carrette F, Duong-Polk K, Bagchi A, Scott DA, Lowy AM, Bradley LM, Commisso C. PMID: 39677772; PMCID: PMC11642790.
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Quantification of PD-L1 expression and tumor mutational burden in biologically distinct advanced pancreatic cancers responding to pembrolizumab: case reports. Front Immunol. 2024; 15:1452543. Li KY, Lowy AM, Fanta P. PMID: 39687619; PMCID: PMC11646977.
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Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment. Mol Cancer Ther. 2024 Nov 04; 23(11):1597-1612. Erdem S, Lee HJ, Shankara Narayanan JSN, Tharuka MDN, De la Torre J, Ren T, Kuang Y, Abeywardana T, Li K, Berger AJ, Lowy AM, White RR, Chen Y. PMID: 39150446; PMCID: PMC11534524.
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Cyclin-Dependent Kinase 4/6 Inhibition as a Novel Therapy for Peritoneal Mucinous Carcinomatosis With GNAS Mutations. J Clin Oncol. 2025 Feb 20; 43(6):705-715. Weitz J, Nishizaki D, Liau J, Patel J, Ng I, Sun S, Ramms D, Zou J, Wishart B, Rull J, Baumgartner J, Kelly K, White R, Veerapong J, Hosseini M, Patel H, Botta G, Gutkind JS, Tiriac H, Kato S, Lowy AM. PMID: 39413348; PMCID: PMC11829827.
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MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis. bioRxiv. 2024 Jun 30. Garg B, Khan S, Babu DS, Mose E, Gulay K, Sharma S, Sood D, Wenzel AT, Martsinkovskiy A, Patel J, Jaquish D, Lambies G, D'Ippolito A, Austgen K, Johnston B, Orlando D, Jang GH, Gallinger S, Goodfellow E, Brodt P, Commisso C, Tamayo P, Mesirov JP, Tiriac H, Lowy AM. PMID: 38979336; PMCID: PMC11230455.
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ZBTB11 Depletion Targets Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC. bioRxiv. 2024 May 21. Tran NL, Jiang J, Ma M, Gadbois GE, Gulay KCM, Verano A, Zhou H, Huang CT, Scott DA, Bang AG, Tiriac H, Lowy AM, Wang ES, Ferguson FM. PMID: 38826238; PMCID: PMC11142081.
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The Pancreatic Cancer Early Detection (PRECEDE) Study is a Global Effort to Drive Early Detection: Baseline Imaging Findings in High-Risk Individuals. J Natl Compr Canc Netw. 2024 04; 22(3):158-166. Zogopoulos G, Haimi I, Sanoba SA, Everett JN, Wang Y, Katona BW, Farrell JJ, Grossberg AJ, Paiella S, Klute KA, Bi Y, Wallace MB, Kwon RS, Stoffel EM, Wadlow RC, Sussman DA, Merchant NB, Permuth JB, Golan T, Raitses-Gurevich M, Lowy AM, Liau J, Jeter JM, Lindberg JM, Chung DC, Earl J, Brentnall TA, Schrader KA, Kaul V, Huang C, Chandarana H, Smerdon C, Graff JJ, Kastrinos F, Kupfer SS, Lucas AL, Sears RC, Brand RE, Parmigiani G, Simeone DM, PRECEDE Consortium. PMID: 38626807; PMCID: PMC12344727.
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A Randomized Trial of Two Remote Health Care Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study. Gastroenterology. 2024 05; 166(5):872-885.e2. Rodriguez NJ, Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Fortes I, Caruso A, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Zhou AY, Coffin TB, Uno H, Horiguchi M, Ocean AJ, McAllister F, Lowy AM, Klein AP, Madlensky L, Petersen GM, Garber JE, Lippman SM, Goggins MG, Maitra A, Syngal S. PMID: 38320723; PMCID: PMC11034726.
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Body composition measurements and clinical outcomes in patients with resectable pancreatic adenocarcinoma - analysis from SWOG S1505. J Gastrointest Surg. 2024 Mar; 28(3):232-235. Sohal DPS, Boutin RD, Lenchik L, Kim J, Beg MS, Wang-Gillam A, Wade JL, Guthrie KA, Chiorean EG, Ahmad SA, Lowy AM, Philip PA, Chang VT. PMID: 38445914.
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Intratumoral Cell Neighborhoods Coordinate Outcomes in Pancreatic Ductal Adenocarcinoma. Gastroenterology. 2024 06; 166(6):1114-1129. Wattenberg MM, Colby S, Garrido-Laguna I, Xue Y, Chang R, Delman D, Lee J, Affolter K, Mulvihill SJ, Beg MS, Wang-Gillam A, Wade JL, Guthrie KA, Chiorean EG, Ahmad SA, Lowy AM, Philip PA, Sohal DPS, Beatty GL. PMID: 38244727; PMCID: PMC11102852.
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The effect of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. JCI Insight. 2024 01 09; 9(1). Lumibao JC, Okhovat SR, Peck KL, Lin X, Lande K, Yomtoubian S, Ng I, Tiriac H, Lowy AM, Zou J, Engle DD. PMID: 38051586; PMCID: PMC10906458.
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Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project. Cancer Res Commun. 2023 10 10; 3(10):2062-2073. Semaan A, Bernard V, Wong J, Makino Y, Swartzlander DB, Rajapakshe KI, Lee JJ, Officer A, Schmidt CM, Wu HH, Scaife CL, Affolter KE, Nachmanson D, Firpo MA, Yip-Schneider M, Lowy AM, Harismendy O, Sen S, Maitra A, Jakubek YA, Guerrero PA. PMID: 37721516; PMCID: PMC10563795.
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Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma. Nat Cancer. 2024 01; 5(1):100-113. Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, Maganti S, Duong-Polk K, Bhullar D, Naeem R, Scott DA, Lowy AM, Tiriac H, Commisso C. PMID: 37814011; PMCID: PMC10956382.
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Single-cell mapping identifies MSI+ cells as a common origin for diverse subtypes of pancreatic cancer. Cancer Cell. 2023 11 13; 41(11):1989-2005.e9. Rajbhandari N, Hamilton M, Quintero CM, Ferguson LP, Fox R, Schürch CM, Wang J, Nakamura M, Lytle NK, McDermott M, Diaz E, Pettit H, Kritzik M, Han H, Cridebring D, Wen KW, Tsai S, Goggins MG, Lowy AM, Wechsler-Reya RJ, Von Hoff DD, Newman AM, Reya T. PMID: 37802055; PMCID: PMC10836835.
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Dual Inhibition of KRASG12D and Pan-ERBB Is Synergistic in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2023 09 15; 83(18):3001-3012. Gulay KCM, Zhang X, Pantazopoulou V, Patel J, Esparza E, Pran Babu DS, Ogawa S, Weitz J, Ng I, Mose ES, Pu M, Engle DD, Lowy AM, Tiriac H. PMID: 37378556; PMCID: PMC10502451.
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A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023 09 06; 14(1):5195. Antal CE, Oh TG, Aigner S, Luo EC, Yee BA, Campos T, Tiriac H, Rothamel KL, Cheng Z, Jiao H, Wang A, Hah N, Lenkiewicz E, Lumibao JC, Truitt ML, Estepa G, Banayo E, Bashi S, Esparza E, Munoz RM, Diedrich JK, Sodir NM, Mueller JR, Fraser CR, Borazanci E, Propper D, Von Hoff DD, Liddle C, Yu RT, Atkins AR, Han H, Lowy AM, Barrett MT, Engle DD, Evan GI, Yeo GW, Downes M, Evans RM. PMID: 37673892; PMCID: PMC10482938.
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Syk Inhibition Reprograms Tumor-Associated Macrophages and Overcomes Gemcitabine-Induced Immunosuppression in Pancreatic Ductal Adenocarcinoma. Cancer Res. 2023 08 15; 83(16):2675-2689. Rohila D, Park IH, Pham TV, Weitz J, Hurtado de Mendoza T, Madheswaran S, Ishfaq M, Beaman C, Tapia E, Sun S, Patel J, Tamayo P, Lowy AM, Joshi S. PMID: 37306759; PMCID: PMC10416758.
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Pancreatic ductal adenocarcinoma induces neural injury that promotes a transcriptomic and functional repair signature by peripheral neuroglia. Oncogene. 2023 08; 42(34):2536-2546. Weitz J, Garg B, Martsinkovskiy A, Patel S, Tiriac H, Lowy AM. PMID: 37433986; PMCID: PMC10880465.
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Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023 07; 21(7):753-782. Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD. PMID: 37433437.
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Tumor-resident regulatory T cells in pancreatic cancer express the αvβ5 integrin as a targetable activation marker. bioRxiv. 2023 May 24. Suzuki K, Kunisada Y, Miyamura N, Eikawa S, Hurtado de Mendoza T, Mose ES, Lu C, Kuroda Y, Ruoslahti E, Lowy AM, Sugahara KN. PMID: 37292693; PMCID: PMC10245898.
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A pancreatic cancer mouse model with human immunity. bioRxiv. 2023 May 24. Miyamura N, Suzuki K, Friedman RA, Floratos A, Kunisada Y, Masuda K, Lowy AM, Tsuji M, Sugahara KN. PMID: 37292766; PMCID: PMC10245824.
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Pancreatic Ductal Adenocarcinoma Induces Neural Injury that Promotes a Transcriptomic and Functional Repair Signature by Peripheral Neuroglia. Res Sq. 2023 Mar 28. Weitz J, Garg B, Tiriac H, Martsinkovskiy A, Patel S, Lowy A. PMID: 37034696; PMCID: PMC10081383.
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Publisher Correction: Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2023 Mar; 615(7953):E24. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner D, Sun B, Karin M. PMID: 36882540; PMCID: PMC10033397.
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Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinoma. Nat Commun. 2023 01 18; 14(1):292. Ferguson LP, Gatchalian J, McDermott ML, Nakamura M, Chambers K, Rajbhandari N, Lytle NK, Rosenthal SB, Hamilton M, Albini S, Wartenberg M, Zlobec I, Galván JA, Karamitopoulou E, Vavinskaya V, Wascher A, Lowy AM, Schürch CM, Puri PL, Bruneau BG, Hargreaves DC, Reya T. PMID: 36653361; PMCID: PMC9849267.
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Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation. Nat Cell Biol. 2023 02; 25(2):309-322. Wu C, Rakhshandehroo T, Wettersten HI, Campos A, von Schalscha T, Jain S, Yu Z, Tan J, Mose E, Childers BG, Lowy AM, Weis SM, Cheresh DA. PMID: 36646789; PMCID: PMC10280815.
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Culture and Imaging of Ex Vivo Organotypic Pseudomyxoma Peritonei Tumor Slices from Resected Human Tumor Specimens. J Vis Exp. 2022 12 09; (190). Weitz J, Montecillo Gulay KC, Hurtado de Mendoza T, Tiriac H, Baumgartner J, Kelly K, Veerapong J, Lowy AM. PMID: 36571414; PMCID: PMC10880464.
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Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a prospective clinical trial and comparative analysis. Surg Endosc. 2023 07; 37(7):5644-5651. Cho CY, Veerapong J, Baumgartner JM, Murphy JD, Lowy AM, Kelly KJ. PMID: 36477643; PMCID: PMC10322763.
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A Preclinical and Phase Ib Study of Palbociclib plus Nab-Paclitaxel in Patients with Metastatic Adenocarcinoma of the Pancreas. Cancer Res Commun. 2022 11; 2(11):1326-1333. Hidalgo M, Garcia-Carbonero R, Lim KH, Messersmith WA, Garrido-Laguna I, Borazanci E, Lowy AM, Medina Rodriguez L, Laheru D, Salvador-Barbero B, Malumbres M, Shields DJ, Grossman JE, Huang X, Tammaro M, Martini JF, Yu Y, Kern K, Macarulla T. PMID: 36970055; PMCID: PMC10035387.
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An Ex Vivo Organotypic Culture Platform for Functional Interrogation of Human Appendiceal Cancer Reveals a Prominent and Heterogenous Immunological Landscape. Clin Cancer Res. 2022 11 01; 28(21):4793-4806. Weitz J, Hurtado de Mendoza T, Tiriac H, Lee J, Sun S, Garg B, Patel J, Li K, Baumgartner J, Kelly KJ, Veerapong J, Hosseini M, Chen Y, Lowy AM. PMID: 36067351.
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Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC? Ann Surg Oncol. 2023 Feb; 30(2):768-773. Khan S, Doan NH, Hosseini M, Kelly K, Veerapong J, Lowy AM, Baumgartner J. PMID: 36305990; PMCID: PMC9807473.
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Alvimopan for Enhanced Gastrointestinal Recovery after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: A Randomized Controlled Trial. J Am Coll Surg. 2022 11 01; 235(5):693-701. Baumgartner JM, Chen R, Messer K, Veerapong J, Kelly KJ, Ramamoorthy S, Lowy AM. PMID: 36102565.
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Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. Nature. 2022 10; 610(7931):366-372. Su H, Yang F, Fu R, Trinh B, Sun N, Liu J, Kumar A, Baglieri J, Siruno J, Le M, Li Y, Dozier S, Nair A, Filliol A, Sinchai N, Rosenthal SB, Santini J, Metallo CM, Molina A, Schwabe RF, Lowy AM, Brenner DA, Sun B, Karin M. PMID: 36198801; PMCID: PMC9588640.
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The MST1R/RON Tyrosine Kinase in Cancer: Oncogenic Functions and Therapeutic Strategies. Cancers (Basel). 2022 Apr 18; 14(8). Cazes A, Childers BG, Esparza E, Lowy AM. PMID: 35454943; PMCID: PMC9027306.
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Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test. Commun Med (Lond). 2022; 2:29. Hinestrosa JP, Kurzrock R, Lewis JM, Schork NJ, Schroeder G, Kamat AM, Lowy AM, Eskander RN, Perrera O, Searson D, Rastegar K, Hughes JR, Ortiz V, Clark I, Balcer HI, Arakelyan L, Turner R, Billings PR, Adler MJ, Lippman SM, Krishnan R. PMID: 35603292; PMCID: PMC9053211.
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Fluorescent Anti-MUC5AC Brightly Targets Pancreatic Cancer in a Patient-derived Orthotopic Xenograft. In Vivo. 2022 Jan-Feb; 36(1):57-62. Turner MA, Hollandsworth HM, Nishino H, Amirfakhri S, Lwin TM, Lowy AM, Kaur S, Natarajan G, Mallya K, Hoffman RM, Batra SK, Bouvet M. PMID: 34972700; PMCID: PMC8765132.
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Establishment of Patient-Derived Pancreatic Cancer Organoids from Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsies. Gut Liver. 2022 07 15; 16(4):625-636. Lee JH, Kim H, Lee SH, Ku JL, Chun JW, Seo HY, Kim SC, Paik WH, Ryu JK, Lee SK, Lowy AM, Kim YT. PMID: 34916338; PMCID: PMC9289822.
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Author Correction: Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2021 Dec; 600(7889):E18. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 34848876.
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Palbociclib as a Novel Therapy for Low-Grade Mucinous Carcinomatosis Peritonei of Appendiceal Origin. JCO Precis Oncol. 2021 11; 5:1069-1072. Childers BG, Sood D, Patel R, Mose ES, Hosseini M, Kato S, Baumgartner JM, Lowy AM. PMID: 34994628.
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Novel Models of Genetic Education and Testing for Pancreatic Cancer Interception: Preliminary Results from the GENERATE Study. Cancer Prev Res (Phila). 2021 11; 14(11):1021-1032. Furniss CS, Yurgelun MB, Ukaegbu C, Constantinou PE, Lafferty CC, Talcove-Berko ER, Schwartz AN, Stopfer JE, Underhill-Blazey M, Kenner B, Nelson SH, Okumura S, Law S, Zhou AY, Coffin TB, Rodriguez NJ, Uno H, Ocean AJ, McAllister F, Lowy AM, Lippman SM, Klein AP, Madlensky L, Petersen GM, Garber JE, Goggins MG, Maitra A, Syngal S. PMID: 34625409; PMCID: PMC8563400.
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Using Organotypic Tissue Slices to Investigate the Microenvironment of Pancreatic Cancer: Pharmacotyping and Beyond. Cancers (Basel). 2021 Oct 05; 13(19). Weitz JR, Tiriac H, Hurtado de Mendoza T, Wascher A, Lowy AM. PMID: 34638476; PMCID: PMC8507648.
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Randomized Phase II Study of PARP Inhibitor ABT-888 (Veliparib) with Modified FOLFIRI versus FOLFIRI as Second-line Treatment of Metastatic Pancreatic Cancer: SWOG S1513. Clin Cancer Res. 2021 12 01; 27(23):6314-6322. Chiorean EG, Guthrie KA, Philip PA, Swisher EM, Jalikis F, Pishvaian MJ, Berlin J, Noel MS, Suga JM, Garrido-Laguna I, Cardin DB, Radke MR, Duong M, Bellasea S, Lowy AM, Hochster HS. PMID: 34580114; PMCID: PMC8639715.
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Targeting the IGF-Axis Potentiates Immunotherapy for Pancreatic Ductal Adenocarcinoma Liver Metastases by Altering the Immunosuppressive Microenvironment. Mol Cancer Ther. 2021 12; 20(12):2469-2482. Hashimoto M, Konda JD, Perrino S, Celia Fernandez M, Lowy AM, Brodt P. PMID: 34552012; PMCID: PMC8677570.
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Tri-modal management of primary small cell carcinoma of the pancreas (SCCP): a rare neuroendocrine carcinoma (NEC). BMC Gastroenterol. 2021 Sep 03; 21(1):340. Elzein S, Bao F, Lin R, Schnickel G, Lowy AM, Botta GP. PMID: 34479480; PMCID: PMC8414857.
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Ki67 does not predict recurrence for low-grade appendiceal mucinous neoplasms with peritoneal dissemination after cytoreductive surgery and HIPEC. Hum Pathol. 2021 Jul; 113:104-110. Ward EP, Okamuro L, Khan S, Hosseini M, Valasek MA, Ronquillo N, Kelly KJ, Veerapong J, Lowy AM, Baumgartner J. PMID: 33905776.
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Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2021 04 01; 19(4):439-457. Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, Chiorean EG, Chung V, Czito B, Del Chiaro M, Dillhoff M, Donahue TR, Dotan E, Ferrone CR, Fountzilas C, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Moravek C, Nakakura EK, Narang AK, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Vollmer C, Wolff RA, Wolpin BM, Lynn B, George GV. PMID: 33845462.
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Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer Cell. 2021 05 10; 39(5):678-693.e11. Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B, Karin M. PMID: 33740421; PMCID: PMC8119368.
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Tumor-penetrating therapy for β5 integrin-rich pancreas cancer. Nat Commun. 2021 03 09; 12(1):1541. Hurtado de Mendoza T, Mose ES, Botta GP, Braun GB, Kotamraju VR, French RP, Suzuki K, Miyamura N, Teesalu T, Ruoslahti E, Lowy AM, Sugahara KN. PMID: 33750829; PMCID: PMC7943581.
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Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness. Cancer Discov. 2021 07; 11(7):1808-1825. Zhang Y, Recouvreux MV, Jung M, Galenkamp KMO, Li Y, Zagnitko O, Scott DA, Lowy AM, Commisso C. PMID: 33653692; PMCID: PMC8292164.
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Clinical Data Prediction Model to Identify Patients With Early-Stage Pancreatic Cancer. JCO Clin Cancer Inform. 2021 03; 5:279-287. Chen Q, Cherry DR, Nalawade V, Qiao EM, Kumar A, Lowy AM, Simpson DR, Murphy JD. PMID: 33739856; PMCID: PMC8462624.
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Efficacy of Perioperative Chemotherapy for Resectable Pancreatic Adenocarcinoma: A Phase 2 Randomized Clinical Trial. JAMA Oncol. 2021 03 01; 7(3):421-427. Sohal DPS, Duong M, Ahmad SA, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS. PMID: 33475684; PMCID: PMC7821078.
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Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis. Oncogene. 2021 03; 40(11):1957-1973. Yoon H, Tang CM, Banerjee S, Yebra M, Noh S, Burgoyne AM, Torre J, Siena M, Liu M, Klug LR, Choi YY, Hosseini M, Delgado AL, Wang Z, French RP, Lowy A, DeMatteo RP, Heinrich MC, Molinolo AA, Gutkind JS, Harismendy O, Sicklick JK. PMID: 33603171; PMCID: PMC7979540.
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Phase I Trial of Stereotactic Body Radiation Therapy Dose Escalation in Pancreatic Cancer. Int J Radiat Oncol Biol Phys. 2021 Jul 15; 110(4):1003-1012. Courtney PT, Paravati AJ, Atwood TF, Raja N, Zimmerman CT, Fanta PT, Lowy AM, Simpson DR, Xu R, Murphy JD. PMID: 33571625.
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Neoadjuvant Checkpoint Blockade in Lynch Syndrome-Related Pancreatic Adenocarcinoma. Pancreas. 2021 02 01; 50(2):e22-e24. Childers BG, Valasek MA, Patel H, Lowy AM. PMID: 33565809.
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A Multi-institutional Study of Peritoneal Recurrence Following Resection of Low-grade Appendiceal Mucinous Neoplasms. Ann Surg Oncol. 2021 Aug; 28(8):4685-4694. Baumgartner JM, Srivastava A, Melnitchouk N, Drage MG, Huber AR, Gonzalez RS, Bell P, Wu E, Resnick M, Turaga K, Poli E, Esquivel J, Deneve J, Kelly KJ, Veerapong J, Lowy AM. PMID: 33415564.
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Preoperative bevacizumab does not increase complications following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. PLoS One. 2020; 15(12):e0243252. King BH, Baumgartner JM, Kelly KJ, Marmor RA, Lowy AM, Veerapong J. PMID: 33270763; PMCID: PMC7714141.
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Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer. J Exp Med. 2020 09 07; 217(9). Recouvreux MV, Moldenhauer MR, Galenkamp KMO, Jung M, James B, Zhang Y, Lowy A, Bagchi A, Commisso C. PMID: 32510550; PMCID: PMC7478719.
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Surgical Outcome Results From SWOG S1505: A Randomized Clinical Trial of mFOLFIRINOX Versus Gemcitabine/Nab-paclitaxel for Perioperative Treatment of Resectable Pancreatic Ductal Adenocarcinoma. Ann Surg. 2020 09 01; 272(3):481-486. Ahmad SA, Duong M, Sohal DPS, Gandhi NS, Beg MS, Wang-Gillam A, Wade JL, Chiorean EG, Guthrie KA, Lowy AM, Philip PA, Hochster HS. PMID: 32740235; PMCID: PMC7856053.
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Prognostic Utility of Pre- and Postoperative Circulating Tumor DNA Liquid Biopsies in Patients with Peritoneal Metastases. Ann Surg Oncol. 2020 Sep; 27(9):3259-3267. Baumgartner JM, Riviere P, Lanman RB, Kelly KJ, Veerapong J, Lowy AM, Kurzrock R. PMID: 32767050; PMCID: PMC7470602.
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Institutional variation in recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: An opportunity for enhanced recovery pathways. J Surg Oncol. 2020 Oct; 122(5):980-985. Eng OS, Blakely AM, Lafaro KJ, Fournier KF, Fackche NT, Johnston FM, Dineen S, Powers B, Hendrix R, Lambert LA, Ronnekleiv-Kelly S, Walle KV, Grotz TE, Leiting JL, Patel SH, Dhar VK, Baumgartner JM, Lowy AM, Clarke CN, Mogal H, Zaidi MY, Staley CA, Kimbrough C, Cloyd JM, Lee B, Raoof M. PMID: 32627199.
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Results of the NRG Oncology/RTOG 0848 Adjuvant Chemotherapy Question-Erlotinib+Gemcitabine for Resected Cancer of the Pancreatic Head: A Phase II Randomized Clinical Trial. Am J Clin Oncol. 2020 03; 43(3):173-179. Abrams RA, Winter KA, Safran H, Goodman KA, Regine WF, Berger AC, Gillin MT, Philip PA, Lowy AM, Wu A, DiPetrillo TA, Corn BW, Seaward SA, Haddock MG, Song S, Jiang Y, Fisher BJ, Katz AW, Mehta S, Willett CG, Crane CH. PMID: 31985516; PMCID: PMC7280743.
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Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases. Nat Commun. 2019 12 17; 10(1):5745. Milette S, Hashimoto M, Perrino S, Qi S, Chen M, Ham B, Wang N, Istomine R, Lowy AM, Piccirillo CA, Brodt P. PMID: 31848339; PMCID: PMC6917725.
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Precision Chemoradiotherapy for HER2 Tumors Using Antibody Conjugates of an Auristatin Derivative with Reduced Cell Permeability. Mol Cancer Ther. 2020 01; 19(1):157-167. Hingorani DV, Doan MK, Camargo MF, Aguilera J, Song SM, Pizzo D, Scanderbeg DJ, Cohen EEW, Lowy AM, Adams SR, Advani SJ. PMID: 31597712; PMCID: PMC6946877.
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Detection and Quantification of GPCR mRNA: An Assessment and Implications of Data from High-Content Methods. ACS Omega. 2019 Oct 15; 4(16):17048-17059. Sriram K, Wiley SZ, Moyung K, Gorr MW, Salmerón C, Marucut J, French RP, Lowy AM, Insel PA. PMID: 31646252; PMCID: PMC6796235.
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Association of an acute pain service with postoperative outcomes following pancreaticoduodenectomy. J Perioper Pract. 2019 10; 30(10):309-314. Said ET, Sztain JF, Swisher MW, Martin EI, Sood D, Lowy AM, Gabriel RA. PMID: 31524066.
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Optimal Surveillance Frequency After CRS/HIPEC for Appendiceal and Colorectal Neoplasms: A Multi-institutional Analysis of the US HIPEC Collaborative. Ann Surg Oncol. 2020 Jan; 27(1):134-146. Gamboa AC, Zaidi MY, Lee RM, Speegle S, Switchenko JM, Lipscomb J, Cloyd JM, Ahmed A, Grotz T, Leiting J, Fournier K, Lee AJ, Dineen S, Powers BD, Lowy AM, Kotha NV, Clarke C, Gamblin TC, Patel SH, Lee TC, Lambert L, Hendrix RJ, Abbott DE, Vande Walle K, Lafaro K, Lee B, Johnston FM, Greer J, Russell MC, Staley CA, Maithel SK. PMID: 31243668; PMCID: PMC6925634.
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Obstruction-Free Survival Following Operative Intervention for Malignant Bowel Obstruction in Appendiceal Cancer. Ann Surg Oncol. 2019 Oct; 26(11):3611-3617. Baumgartner JM, Marmor R, Hsu A, Veerapong J, Kelly KJ, Lowy AM. PMID: 31190209.
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Incidence, Risk Factors, and Prevention Strategies for Venous Thromboembolism after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2019 Jul; 26(7):2276-2284. Khan S, Kelly KJ, Veerapong J, Lowy AM, Baumgartner JM. PMID: 31065960.
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Primary Tumor Sidedness is Predictive of Survival in Colon Cancer Patients Treated with Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy: A US HIPEC Collaborative Study. Ann Surg Oncol. 2019 Jul; 26(7):2234-2240. Kotha NV, Baumgartner JM, Veerapong J, Cloyd JM, Ahmed A, Grotz TE, Leiting JL, Fournier K, Lee AJ, Dineen SP, Dessureault S, Clarke C, Mogal H, Zaidi MY, Russell MC, Patel SH, Sussman JJ, Dhar V, Lambert LA, Hendrix RJ, Abbott DE, Pokrzywa C, Lafaro K, Lee B, Greer JB, Fackche N, Lowy AM, Kelly KJ. PMID: 31016486.
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Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring. Nature. 2019 05; 569(7754):131-135. Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann AM, Ridinger-Saison M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm TP, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Reya T, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, Hunter T. PMID: 30996350; PMCID: PMC6565370.
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MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages. Oncogene. 2019 07; 38(28):5599-5611. Babicky ML, Harper MM, Chakedis J, Cazes A, Mose ES, Jaquish DV, French RP, Childers B, Alakus H, Schmid MC, Foubert P, Miyamoto J, Holman PJ, Walterscheid ZJ, Tang CM, Varki N, Sicklick JK, Messer K, Varner JA, Waltz SE, Lowy AM. PMID: 30967626; PMCID: PMC6625868.
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A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell. 2019 04 18; 177(3):572-586.e22. Lytle NK, Ferguson LP, Rajbhandari N, Gilroy K, Fox RG, Deshpande A, Schürch CM, Hamilton M, Robertson N, Lin W, Noel P, Wartenberg M, Zlobec I, Eichmann M, Galván JA, Karamitopoulou E, Gilderman T, Esparza LA, Shima Y, Spahn P, French R, Lewis NE, Fisch KM, Sasik R, Rosenthal SB, Kritzik M, Von Hoff D, Han H, Ideker T, Deshpande AJ, Lowy AM, Adams PD, Reya T. PMID: 30955884; PMCID: PMC6711371.
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Pancreatic Adenocarcinoma, Version 1.2019. J Natl Compr Canc Netw. 2019 03 01; 17(3):202-210. Tempero MA, Malafa MP, Chiorean EG, Czito B, Scaife C, Narang AK, Fountzilas C, Wolpin BM, Al-Hawary M, Asbun H, Behrman SW, Benson AB, Binder E, Cardin DB, Cha C, Chung V, Dillhoff M, Dotan E, Ferrone CR, Fisher G, Hardacre J, Hawkins WG, Ko AH, LoConte N, Lowy AM, Moravek C, Nakakura EK, O'Reilly EM, Obando J, Reddy S, Thayer S, Wolff RA, Burns JL, Zuccarino-Catania G. PMID: 30865919.
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Exosomes from Pancreatic Juice: A Step Closer to the Holy Grail? Ann Surg Oncol. 2019 Jul; 26(7):1961-1962. Lowy AM. PMID: 30820788; PMCID: PMC6545269.
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Does Primary Tumor Side Matter in Patients with Metastatic Colon Cancer Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy? Ann Surg Oncol. 2019 May; 26(5):1421-1427. Kelly KJ, Alsayadnasser M, Vaida F, Veerapong J, Baumgartner JM, Patel S, Ahmad S, Barone R, Lowy AM. PMID: 30815802.
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BAP1 haploinsufficiency predicts a distinct immunogenic class of malignant peritoneal mesothelioma. Genome Med. 2019 02 18; 11(1):8. Shrestha R, Nabavi N, Lin YY, Mo F, Anderson S, Volik S, Adomat HH, Lin D, Xue H, Dong X, Shukin R, Bell RH, McConeghy B, Haegert A, Brahmbhatt S, Li E, Oo HZ, Hurtado-Coll A, Fazli L, Zhou J, McConnell Y, McCart A, Lowy A, Morin GB, Chen T, Daugaard M, Sahinalp SC, Hach F, Le Bihan S, Gleave ME, Wang Y, Churg A, Collins CC. PMID: 30777124; PMCID: PMC6378747.
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Inhibition of invasive pancreatic cancer: restoring cell apoptosis by activating mitochondrial p53. Am J Cancer Res. 2019; 9(2):390-405. Cheng J, Okolotowicz KJ, Ryan D, Mose E, Lowy AM, Cashman JR. PMID: 30906636; PMCID: PMC6405982.
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Genomic Landscape of Appendiceal Neoplasms. JCO Precis Oncol. 2018; 2. Ang CS, Shen JP, Hardy-Abeloos CJ, Huang JK, Ross JS, Miller VA, Jacobs MT, Chen IL, Xu D, Ali SM, Baumgartner J, Lowy A, Fanta P, Ideker T, Millis SZ, Harismendy O. PMID: 32913983; PMCID: PMC7446344.
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Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab. Am J Clin Oncol. 2018 07; 41(7):716-721. Meredith RF, Torgue JJ, Rozgaja TA, Banaga EP, Bunch PW, Alvarez RD, Straughn JM, Dobelbower MC, Lowy AM. PMID: 27906723; PMCID: PMC5449266.
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Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival. Ann Surg Oncol. 2018 Aug; 25(8):2400-2408. Baumgartner JM, Raymond VM, Lanman RB, Tran L, Kelly KJ, Lowy AM, Kurzrock R. PMID: 29948422; PMCID: PMC6044413.
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GPCRomics: GPCR Expression in Cancer Cells and Tumors Identifies New, Potential Biomarkers and Therapeutic Targets. Front Pharmacol. 2018; 9:431. Insel PA, Sriram K, Wiley SZ, Wilderman A, Katakia T, McCann T, Yokouchi H, Zhang L, Corriden R, Liu D, Feigin ME, French RP, Lowy AM, Murray F. PMID: 29872392; PMCID: PMC5972277.
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E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol. 2018; 6(2):181-198. Scully KM, Lahmy R, Signaevskaia L, Sasik R, Medal R, Kim H, French R, James B, Wu Y, Lowy AM, Itkin-Ansari P. PMID: 30003124; PMCID: PMC6039985.
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Cirrhosis is not a contraindication to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in highly selected patients. World J Surg Oncol. 2018 Apr 26; 16(1):87. Weiss A, Ward EP, Baumgartner JM, Lowy AM, Kelly KJ. PMID: 29699564; PMCID: PMC5922306.
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GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells. FASEB J. 2018 03; 32(3):1170-1183. Wiley SZ, Sriram K, Liang W, Chang SE, French R, McCann T, Sicklick J, Nishihara H, Lowy AM, Insel PA. PMID: 29092903; PMCID: PMC5892729.
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Histologic Predictors of Recurrence in Mucinous Appendiceal Tumors with Peritoneal Dissemination after HIPEC. Ann Surg Oncol. 2018 Mar; 25(3):702-708. Reghunathan M, Kelly KJ, Valasek MA, Lowy AM, Baumgartner JM. PMID: 29282599.
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Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy. PLoS One. 2017; 12(12):e0189051. Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Spike BT, Shokhirev MN, Liddle C, Yu RT, Downes M, Evans RM, Saghatelian A, Lowy AM, Wahl GM. PMID: 29211796; PMCID: PMC5718507.
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Clinical Management: Resectable Disease. Cancer J. 2017 Nov/Dec; 23(6):343-349. White RR, Lowy AM. PMID: 29189330.
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Factors Associated with 60-Day Readmission Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2018 Jan; 25(1):91-97. Kelly KJ, Cajas L, Baumgartner JM, Lowy AM. PMID: 29090402.
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An Intergroup Randomized Phase II Study of Bevacizumab or Cetuximab in Combination with Gemcitabine and in Combination with Chemoradiation in Patients with Resected Pancreatic Carcinoma: A Trial of the ECOG-ACRIN Cancer Research Group (E2204). Oncology. 2018; 94(1):39-46. Berlin JD, Feng Y, Catalano P, Abbruzzese JL, Philip PA, McWilliams RR, Lowy AM, Benson AB, Blackstock AW. PMID: 29040974; PMCID: PMC5828967.
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Prophylactic enoxaparin doses may be inadequate in patients undergoing abdominal cancer surgery. J Surg Res. 2018 01; 221:183-189. Baumgartner JM, McKenzie S, Block S, Costantini TW, Lowy AM. PMID: 29229126.
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Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2017 08; 15(8):1028-1061. Tempero MA, Malafa MP, Al-Hawary M, Asbun H, Bain A, Behrman SW, Benson AB, Binder E, Cardin DB, Cha C, Chiorean EG, Chung V, Czito B, Dillhoff M, Dotan E, Ferrone CR, Hardacre J, Hawkins WG, Herman J, Ko AH, Komanduri S, Koong A, LoConte N, Lowy AM, Moravek C, Nakakura EK, O'Reilly EM, Obando J, Reddy S, Scaife C, Thayer S, Weekes CD, Wolff RA, Wolpin BM, Burns J, Darlow S. PMID: 28784865.
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A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer. Oncotarget. 2017 Aug 08; 8(32):53154-53167. Villarino N, Signaevskaia L, van Niekerk J, Medal R, Kim H, Lahmy R, Scully K, Pinkerton A, Kim S, Lowy A, Itkin-Ansari P. PMID: 28881801; PMCID: PMC5581100.
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Molecular Pathways: Targeting the Microenvironment of Liver Metastases. Clin Cancer Res. 2017 Nov 01; 23(21):6390-6399. Milette S, Sicklick JK, Lowy AM, Brodt P. PMID: 28615370; PMCID: PMC5668192.
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Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS One. 2017; 12(6):e0179216. Valasek MA, Thung I, Gollapalle E, Hodkoff AA, Kelly KJ, Baumgartner JM, Vavinskaya V, Lin GY, Tipps AP, Hosseini MV, Lowy AM. PMID: 28591173; PMCID: PMC5462425.
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Hyaluronan-binding peptide for targeting peritoneal carcinomatosis. Tumour Biol. 2017 May; 39(5):1010428317701628. Ikemoto H, Lingasamy P, Anton Willmore AM, Hunt H, Kurm K, Tammik O, Scodeller P, Simón-Gracia L, Kotamraju VR, Lowy AM, Sugahara KN, Teesalu T. PMID: 28468593; PMCID: PMC5697747.
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TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function. Oncogene. 2017 07 27; 36(30):4336-4348. Principe DR, Diaz AM, Torres C, Mangan RJ, DeCant B, McKinney R, Tsao MS, Lowy A, Munshi HG, Jung B, Grippo PJ. PMID: 28368414; PMCID: PMC5537609.
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Effect of Selumetinib and MK-2206 vs Oxaliplatin and Fluorouracil in Patients With Metastatic Pancreatic Cancer After Prior Therapy: SWOG S1115 Study Randomized Clinical Trial. JAMA Oncol. 2017 Apr 01; 3(4):516-522. Chung V, McDonough S, Philip PA, Cardin D, Wang-Gillam A, Hui L, Tejani MA, Seery TE, Dy IA, Al Baghdadi T, Hendifar AE, Doyle LA, Lowy AM, Guthrie KA, Blanke CD, Hochster HS. PMID: 27978579; PMCID: PMC5665683.
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Preoperative Modified FOLFIRINOX Treatment Followed by Capecitabine-Based Chemoradiation for Borderline Resectable Pancreatic Cancer: Alliance for Clinical Trials in Oncology Trial A021101. JAMA Surg. 2016 08 17; 151(8):e161137. Katz MH, Shi Q, Ahmad SA, Herman JM, Marsh Rde W, Collisson E, Schwartz L, Frankel W, Martin R, Conway W, Truty M, Kindler H, Lowy AM, Bekaii-Saab T, Philip P, Talamonti M, Cardin D, LoConte N, Shen P, Hoffman JP, Venook AP. PMID: 27275632; PMCID: PMC5210022.
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Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget. 2016 Jul 19; 7(29):45959-45975. Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, Holman P, Howard H, Miyamoto J, Porras P, Walterscheid Z, Schultz-Fademrecht C, Esdar C, Schadt O, Eickhoff J, Lowy AM. PMID: 27323855; PMCID: PMC5216774.
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Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature. 2016 06 16; 534(7607):407-411. Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T. PMID: 27281208; PMCID: PMC4998062.
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Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression. Cancer Discov. 2016 08; 6(8):870-85. Kaneda MM, Cappello P, Nguyen AV, Ralainirina N, Hardamon CR, Foubert P, Schmid MC, Sun P, Mose E, Bouvet M, Lowy AM, Valasek MA, Sasik R, Novelli F, Hirsch E, Varner JA. PMID: 27179037; PMCID: PMC5091937.
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PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction. Oncotarget. 2016 May 10; 7(19):28218-34. Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F. PMID: 27058416; PMCID: PMC5053722.
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Urokinase-controlled tumor penetrating peptide. J Control Release. 2016 06 28; 232:188-95. Braun GB, Sugahara KN, Yu OM, Kotamraju VR, Mölder T, Lowy AM, Ruoslahti E, Teesalu T. PMID: 27106816; PMCID: PMC5359125.
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FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine. BMC Cancer. 2016 Jan 16; 16:24. Yeo D, He H, Patel O, Lowy AM, Baldwin GS, Nikfarjam M. PMID: 26774265; PMCID: PMC4715347.
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A Novel Tool for Predicting Major Complications After Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy. Ann Surg Oncol. 2016 May; 23(5):1609-17. Baumgartner JM, Kwong TG, Ma GL, Messer K, Kelly KJ, Lowy AM. PMID: 26678406; PMCID: PMC5841914.
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Laparoscopy is Safe and Accurate to Evaluate Peritoneal Surface Metastasis Prior to Cytoreductive Surgery. Ann Surg Oncol. 2016 May; 23(5):1461-7. Marmor RA, Kelly KJ, Lowy AM, Baumgartner JM. PMID: 26542584.
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A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. Oncogene. 2016 06 23; 35(25):3249-59. Chakedis J, French R, Babicky M, Jaquish D, Howard H, Mose E, Lam R, Holman P, Miyamoto J, Walterscheid Z, Lowy AM. PMID: 26477314; PMCID: PMC4837108.
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A tumor-penetrating peptide enhances circulation-independent targeting of peritoneal carcinomatosis. J Control Release. 2015 Aug 28; 212:59-69. Sugahara KN, Scodeller P, Braun GB, de Mendoza TH, Yamazaki CM, Kluger MD, Kitayama J, Alvarez E, Howell SB, Teesalu T, Ruoslahti E, Lowy AM. PMID: 26071630; PMCID: PMC4508207.
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SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma. J Clin Oncol. 2015 Aug 20; 33(24):2617-22. Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD. PMID: 25964250; PMCID: PMC4534524.
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Approach to patients with pancreatic cancer without detectable metastases. J Clin Oncol. 2015 Jun 01; 33(16):1770-8. Heestand GM, Murphy JD, Lowy AM. PMID: 25918279.
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BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. J Transl Med. 2015 Apr 16; 13:122. Alakus H, Yost SE, Woo B, French R, Lin GY, Jepsen K, Frazer KA, Lowy AM, Harismendy O. PMID: 25889843; PMCID: PMC4422481.
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Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 01; 75(7):1376-1387. Buckel L, Savariar EN, Crisp JL, Jones KA, Hicks AM, Scanderbeg DJ, Nguyen QT, Sicklick JK, Lowy AM, Tsien RY, Advani SJ. PMID: 25681274; PMCID: PMC4458508.
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Single-incision laparoscopic surgery through an ostomy site: a natural approach by an unnatural orifice. Surg Laparosc Endosc Percutan Tech. 2015 Feb; 25(1):74-78. Lopez NE, Peterson CY, Ramamoorthy SL, McLemore EC, Sedrak MF, Lowy AM, Horgan S, Talamini MA, Sicklick JK. PMID: 24743670.
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Laparoscopic evacuation of mucinous ascites for palliation of pseudomyxoma peritonei. Ann Surg Oncol. 2015 May; 22(5):1722-5. Kelly KJ, Baumgartner JM, Lowy AM. PMID: 25395145.
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Tumor-penetrating iRGD peptide inhibits metastasis. Mol Cancer Ther. 2015 Jan; 14(1):120-8. Sugahara KN, Braun GB, de Mendoza TH, Kotamraju VR, French RP, Lowy AM, Teesalu T, Ruoslahti E. PMID: 25392370; PMCID: PMC4297196.
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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov; 20(11):1340-1347. Schönhuber N, Seidler B, Schuck K, Veltkamp C, Schachtler C, Zukowska M, Eser S, Feyerabend TB, Paul MC, Eser P, Klein S, Lowy AM, Banerjee R, Yang F, Lee CL, Moding EJ, Kirsch DG, Scheideler A, Alessi DR, Varela I, Bradley A, Kind A, Schnieke AE, Rodewald HR, Rad R, Schmid RM, Schneider G, Saur D. PMID: 25326799; PMCID: PMC4270133.
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Long-term outcomes after total pancreatectomy and islet cell autotransplantation: is it a durable operation? Ann Surg. 2014 Oct; 260(4):659-65; discussion 665-7. Wilson GC, Sutton JM, Abbott DE, Smith MT, Lowy AM, Matthews JB, Rilo HL, Schmulewitz N, Salehi M, Choe K, Brunner J, Hanseman DJ, Sussman JJ, Edwards MJ, Ahmad SA. PMID: 25203883.
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A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 2014 Nov 15; 74(22):6671-81. Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke RL. PMID: 25261239; PMCID: PMC4233190.
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Predictors of progression in high-grade appendiceal or colorectal peritoneal carcinomatosis after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. 2015 May; 22(5):1716-21. Baumgartner JM, Tobin L, Heavey SF, Kelly KJ, Roeland EJ, Lowy AM. PMID: 25145504.
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Borderline resectable pancreatic cancer: definitions and management. World J Gastroenterol. 2014 Aug 21; 20(31):10740-51. Lopez NE, Prendergast C, Lowy AM. PMID: 25152577; PMCID: PMC4138454.
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The American Society of Peritoneal Surface Malignancies evaluation of HIPEC with Mitomycin C versus Oxaliplatin in 539 patients with colon cancer undergoing a complete cytoreductive surgery. J Surg Oncol. 2014 Dec; 110(7):779-85. Prada-Villaverde A, Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spiliotis J, Torres-Melero J, Turaga K, Trout R. PMID: 25088304.
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Pancreatic adenocarcinoma, version 2.2014: featured updates to the NCCN guidelines. J Natl Compr Canc Netw. 2014 Aug; 12(8):1083-93. Tempero MA, Malafa MP, Behrman SW, Benson AB, Casper ES, Chiorean EG, Chung V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ, Muscarella P, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP, Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. PMID: 25099441.
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Correction: Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(7):53. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 25228923; PMCID: PMC4165363.
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Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727). Cancer. 2014 Oct 01; 120(19):2980-5. Philip PA, Goldman B, Ramanathan RK, Lenz HJ, Lowy AM, Whitehead RP, Wakatsuki T, Iqbal S, Gaur R, Benedetti JK, Blanke CD. PMID: 25041791; PMCID: PMC4284963.
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Homozygous GNAS 393C-allele carriers with locally advanced esophageal cancer fail to benefit from platinum-based preoperative chemoradiotherapy. Ann Surg Oncol. 2014 Dec; 21(13):4375-82. Alakus H, Bollschweiler E, Hölscher AH, Warnecke-Eberz U, Frazer KA, Harismendy O, Lowy AM, Mönig SP, Eberz PM, Maus M, Drebber U, Siffert W, Metzger R. PMID: 24986238.
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Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin. Genome Med. 2014; 6(5):43. Alakus H, Babicky ML, Ghosh P, Yost S, Jepsen K, Dai Y, Arias A, Samuels ML, Mose ES, Schwab RB, Peterson MR, Lowy AM, Frazer KA, Harismendy O. PMID: 24944587; PMCID: PMC4062050.
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The American Society of Peritoneal Surface Malignancies (ASPSM) Multiinstitution Evaluation of the Peritoneal Surface Disease Severity Score (PSDSS) in 1,013 Patients with Colorectal Cancer with Peritoneal Carcinomatosis. Ann Surg Oncol. 2014 Dec; 21(13):4195-201. Esquivel J, Lowy AM, Markman M, Chua T, Pelz J, Baratti D, Baumgartner JM, Berri R, Bretcha-Boix P, Deraco M, Flores-Ayala G, Glehen O, Gomez-Portilla A, González-Moreno S, Goodman M, Halkia E, Kusamura S, Moller M, Passot G, Pocard M, Salti G, Sardi A, Senthil M, Spilioitis J, Torres-Melero J, Turaga K, Trout R. PMID: 24854493.
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An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat Cell Biol. 2014 May; 16(5):457-68. Seguin L, Kato S, Franovic A, Camargo MF, Lesperance J, Elliott KC, Yebra M, Mielgo A, Lowy AM, Husain H, Cascone T, Diao L, Wang J, Wistuba II, Heymach JV, Lippman SM, Desgrosellier JS, Anand S, Weis SM, Cheresh DA. PMID: 24747441; PMCID: PMC4105198.
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Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population-based analysis. JAMA Surg. 2014 Mar; 149(3):237-43. Tran Cao HS, Lopez N, Chang DC, Lowy AM, Bouvet M, Baumgartner JM, Talamini MA, Sicklick JK. PMID: 24402232; PMCID: PMC4383084.
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The RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapies. Pancreas. 2014 Mar; 43(2):183-9. Kang CM, Babicky ML, Lowy AM. PMID: 24518495; PMCID: PMC4009395.
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Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor. J Transl Med. 2014 Feb 10; 12:41. Sicklick JK, Leonard SY, Babicky ML, Tang CM, Mose ES, French RP, Jaquish DV, Hoh CK, Peterson M, Schwab R, Lowy AM. PMID: 24507750; PMCID: PMC3930355.
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Enteral stenting for gastric outlet obstruction and afferent limb syndrome following pancreaticoduodenectomy. Ann Gastroenterol. 2014; 27(4):413-417. Kwong WT, Fehmi SM, Lowy AM, Savides TJ. PMID: 25332208; PMCID: PMC4188946.
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A dual-color genetically engineered mouse model for multispectral imaging of the pancreatic microenvironment. Pancreas. 2013 Aug; 42(6):952-8. Snyder CS, Harrington AR, Kaushal S, Mose E, Lowy AM, Hoffman RM, Bouvet M. PMID: 23648841; PMCID: PMC3713119.
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Consensus guidelines from The American Society of Peritoneal Surface Malignancies on standardizing the delivery of hyperthermic intraperitoneal chemotherapy (HIPEC) in colorectal cancer patients in the United States. Ann Surg Oncol. 2014 May; 21(5):1501-5. Turaga K, Levine E, Barone R, Sticca R, Petrelli N, Lambert L, Nash G, Morse M, Adbel-Misih R, Alexander HR, Attiyeh F, Bartlett D, Bastidas A, Blazer T, Chu Q, Chung K, Dominguez-Parra L, Espat NJ, Foster J, Fournier K, Garcia R, Goodman M, Hanna N, Harrison L, Hoefer R, Holtzman M, Kane J, Labow D, Li B, Lowy A, Mansfield P, Ong E, Pameijer C, Pingpank J, Quinones M, Royal R, Salti G, Sardi A, Shen P, Skitzki J, Spellman J, Stewart J, Esquivel J. PMID: 23793364.
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Therapeutic advances in pancreatic cancer. Gastroenterology. 2013 Jun; 144(6):1316-26. Paulson AS, Tran Cao HS, Tempero MA, Lowy AM. PMID: 23622141.
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PI3Kα activates integrin α4β1 to establish a metastatic niche in lymph nodes. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9042-7. Garmy-Susini B, Avraamides CJ, Desgrosellier JS, Schmid MC, Foubert P, Ellies LG, Lowy AM, Blair SL, Vandenberg SR, Datnow B, Wang HY, Cheresh DA, Varner J. PMID: 23671068; PMCID: PMC3670313.
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Borderline resectable pancreatic cancer: need for standardization and methods for optimal clinical trial design. Ann Surg Oncol. 2013 Aug; 20(8):2787-95. Katz MH, Marsh R, Herman JM, Shi Q, Collison E, Venook AP, Kindler HL, Alberts SR, Philip P, Lowy AM, Pisters PW, Posner MC, Berlin JD, Ahmad SA. PMID: 23435609; PMCID: PMC5600517.
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Changing the way we do business: recommendations to accelerate biomarker development in pancreatic cancer. Clin Cancer Res. 2013 Feb 01; 19(3):538-40. Tempero MA, Klimstra D, Berlin J, Hollingsworth T, Kim P, Merchant N, Moore M, Pleskow D, Wang-Gillam A, Lowy AM. PMID: 23344262.
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Efficacy of dimethylaminoparthenolide and sulindac in combination with gemcitabine in a genetically engineered mouse model of pancreatic cancer. Pancreas. 2013 Jan; 42(1):160-7. Yip-Schneider MT, Wu H, Hruban RH, Lowy AM, Crooks PA, Schmidt CM. PMID: 22699205.
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KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012 May 15; 72(10):2554-64. Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL. PMID: 22589274; PMCID: PMC3366503.
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Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. J Transl Med. 2012 Apr 02; 10:68. Heinrich EL, Lee W, Lu J, Lowy AM, Kim J. PMID: 22472349; PMCID: PMC3342892.
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The RON-receptor regulates pancreatic cancer cell migration through phosphorylation-dependent breakdown of the hemidesmosome. Int J Cancer. 2012 Oct 15; 131(8):1744-54. Yu PT, Babicky M, Jaquish D, French R, Marayuma K, Mose E, Niessen S, Hoover H, Shields D, Cheresh D, Cravatt BF, Lowy AM. PMID: 22275185; PMCID: PMC3424378.
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Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo. Oncotarget. 2011 Nov; 2(11):862-73. Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia-Carracedo D, Wang WM, Kuo CY, Chen D, Arking DE, Lowy AM, Hruban RH, Remotti HE, Su GH. PMID: 22113502; PMCID: PMC3259996.
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IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration. Carcinogenesis. 2011 Aug; 32(8):1151-6. Jaquish DV, Yu PT, Shields DJ, French RP, Maruyama KP, Niessen S, Hoover H, A Cheresh D, Cravatt B, Lowy AM. PMID: 21565828; PMCID: PMC3149203.
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The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma. Mol Cancer Res. 2011 Jun; 9(6):782-90. Lee SH, Hao E, Kiselyuk A, Shapiro J, Shields DJ, Lowy A, Levine F, Itkin-Ansari P. PMID: 21498546; PMCID: PMC3954712.
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Oncogenic Ras/Src cooperativity in pancreatic neoplasia. Oncogene. 2011 May 05; 30(18):2123-34. Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA. PMID: 21242978; PMCID: PMC3104672.
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Effects on blood pressure and cardiovascular risk of variations in patients' adherence to prescribed antihypertensive drugs: role of duration of drug action. Int J Clin Pract. 2011 Jan; 65(1):41-53. Lowy A, Munk VC, Ong SH, Burnier M, Vrijens B, Tousset EP, Urquhart J. PMID: 21091596.
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Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clin Cancer Res. 2010 Jul 15; 16(14):3684-95. Tseng WW, Winer D, Kenkel JA, Choi O, Shain AH, Pollack JR, French R, Lowy AM, Engleman EG. PMID: 20534740; PMCID: PMC3085509.
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Integrin alpha4beta1 signaling is required for lymphangiogenesis and tumor metastasis. Cancer Res. 2010 Apr 15; 70(8):3042-51. Garmy-Susini B, Avraamides CJ, Schmid MC, Foubert P, Ellies LG, Barnes L, Feral C, Papayannopoulou T, Lowy A, Blair SL, Cheresh D, Ginsberg M, Varner JA. PMID: 20388801; PMCID: PMC2856096.
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The RON tyrosine kinase receptor regulates vascular endothelial growth factor production in pancreatic cancer cells. Pancreas. 2010 Apr; 39(3):301-7. Thomas RM, Jaquish DV, French RP, Lowy AM. PMID: 20358644; PMCID: PMC2849173.
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Cystic neoplasms of the pancreas. Surg Oncol Clin N Am. 2010 Apr; 19(2):267-95. Tran Cao HS, Kellogg B, Lowy AM, Bouvet M. PMID: 20159515; PMCID: PMC4383087.
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Pancreatic cancer: preface. Surg Oncol Clin N Am. 2010 Apr; 19(2):xv-xvi. Lowy AM. PMID: 20159512.
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Neoadjuvant therapy may lead to successful surgical resection and improved survival in patients with borderline resectable pancreatic cancer. HPB (Oxford). 2010 Feb; 12(1):73-9. McClaine RJ, Lowy AM, Sussman JJ, Schmulewitz N, Grisell DL, Ahmad SA. PMID: 20495649; PMCID: PMC2814408.
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Silencing of RON receptor signaling promotes apoptosis and gemcitabine sensitivity in pancreatic cancers. Cancer Res. 2010 Feb 01; 70(3):1130-40. Logan-Collins J, Thomas RM, Yu P, Jaquish D, Mose E, French R, Stuart W, McClaine R, Aronow B, Hoffman RM, Waltz SE, Lowy AM. PMID: 20103639; PMCID: PMC2943733.
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Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways. Pancreas. 2010 Jan; 39(1):81-7. Shen X, Artinyan A, Jackson D, Thomas RM, Lowy AM, Kim J. PMID: 19820417.
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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):246-51. Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR, Sansom OJ. PMID: 20018721; PMCID: PMC2806749.
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Case report: focal nesidioblastosis ("nesidioblastoma") in an adult. Hum Pathol. 2010 Mar; 41(3):447-51. McElroy MK, Lowy AM, Weidner N. PMID: 20004945.
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A comparison of pancreaticoduodenectomy and duodenum-preserving head resection for the treatment of chronic pancreatitis. HPB (Oxford). 2009 Dec; 11(8):677-83. McClaine RJ, Lowy AM, Matthews JB, Schmulewitz N, Sussman JJ, Ingraham AM, Ahmad SA. PMID: 20495636; PMCID: PMC2799621.
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Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol. 2009 Nov 20; 27(33):5660-9. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N, Emens L, O'Reilly E, Korc M, Ellis L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese J, Simeone D, Hingorani S, Berlin J, Tepper J. PMID: 19858397; PMCID: PMC7587401.
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CC chemokine receptor 9 enhances proliferation in pancreatic intraepithelial neoplasia and pancreatic cancer cells. J Gastrointest Surg. 2009 Nov; 13(11):1955-62; discussion 1962. Shen X, Mailey B, Ellenhorn JD, Chu PG, Lowy AM, Kim J. PMID: 19756884.
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Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009 Jul; 17(1):62-74. Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM. PMID: 19619492; PMCID: PMC2734336.
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Combined modality treatment of resectable and borderline resectable pancreas cancer: expert consensus statement. Ann Surg Oncol. 2009 Jul; 16(7):1751-6. Abrams RA, Lowy AM, O'Reilly EM, Wolff RA, Picozzi VJ, Pisters PW. PMID: 19390900.
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Treatment of T3 gallbladder cancer. J Gastrointest Surg. 2009 Nov; 13(11):2040-2. Dai M, Fong Y, Lowy A. PMID: 19194769.
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Left-sided pancreatectomy: a multicenter comparison of laparoscopic and open approaches. Ann Surg. 2008 Sep; 248(3):438-46. Kooby DA, Gillespie T, Bentrem D, Nakeeb A, Schmidt MC, Merchant NB, Parikh AA, Martin RC, Scoggins CR, Ahmad S, Kim HJ, Park J, Johnston F, Strouch MJ, Menze A, Rymer J, McClaine R, Strasberg SM, Talamonti MS, Staley CA, McMasters KM, Lowy AM, Byrd-Sellers J, Wood WC, Hawkins WG. PMID: 18791364.
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The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia. Gut. 2008 Nov; 57(11):1555-60. Thomas RM, Kim J, Revelo-Penafiel MP, Angel R, Dawson DW, Lowy AM. PMID: 18664506; PMCID: PMC8634735.
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Beyond the ivory tower: outcomes following surgery for ampullary cancer. Ann Surg Oncol. 2008 Jul; 15(7):1813-4. Lowy AM. PMID: 18425553; PMCID: PMC2467499.
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The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology. 2008 Jul; 135(1):152-62. Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy AM, Groden J. PMID: 18474248; PMCID: PMC2832605.
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Neoadjuvant therapy for pancreatic cancer. J Gastrointest Surg. 2008 Sep; 12(9):1600-8. Lowy AM. PMID: 18259825.
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Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2008 Jul 01; 71(3):741-7. Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. PMID: 18164837; PMCID: PMC4741525.
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Large pancreatic serous cystadenoma presenting with biliary obstruction. Gastrointest Endosc. 2007 Dec; 66(6):1229-30; discussion 1230. O'Toole T, Lowy A, Rabkin E, Chauhan S. PMID: 18061724.
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VEGF expression predicts survival in patients with peritoneal surface metastases from mucinous adenocarcinoma of the appendix and colon. Ann Surg Oncol. 2008 Mar; 15(3):738-44. Logan-Collins JM, Lowy AM, Robinson-Smith TM, Kumar S, Sussman JJ, James LE, Ahmad SA. PMID: 18043973.
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Interstitial brachytherapy for soft tissue sarcoma: A single institution experience. Brachytherapy. 2007 Oct-Dec; 6(4):298-303. Mierzwa ML, McCluskey CM, Barrett WL, Lowy A, Sussman J, Sorger J. PMID: 17959424.
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Fistulojejunostomy for the management of refractory pancreatic fistula. Surgery. 2007 Oct; 142(4):636-42; discussion 642.e1. Nair RR, Lowy AM, McIntyre B, Sussman JJ, Matthews JB, Ahmad SA. PMID: 17950358.
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Mucinous cancer of the appendix: challenges in diagnosis and treatment. J Chemother. 2007 Aug; 19(4):451-4. Andreopoulou E, Yee H, Warycha MA, Macari M, Berman R, Lowy A, Muggia F. PMID: 17855191.
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The RON receptor tyrosine kinase mediates oncogenic phenotypes in pancreatic cancer cells and is increasingly expressed during pancreatic cancer progression. Cancer Res. 2007 Jul 01; 67(13):6075-82. Thomas RM, Toney K, Fenoglio-Preiser C, Revelo-Penafiel MP, Hingorani SR, Tuveson DA, Waltz SE, Lowy AM. PMID: 17616662.
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Intraoperative margin re-resection for colorectal liver metastases. J Surg Educ. 2007 May-Jun; 64(3):150-7. Wray CJ, Lowy AM, Matthews JB, James LE, Mammen JM, Choe KA, Hanto DW, Ahmad SA. PMID: 17574176.
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Wnt/beta-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol. 2007 Jan 12; 7:4. Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM. PMID: 17222338; PMCID: PMC1783845.
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Technology for the delivery of hyperthermic intraoperative intraperitoneal chemotherapy: a survey of techniques. Recent Results Cancer Res. 2007; 169:75-82. Sarnaik AA, Sussman JJ, Ahmad SA, McIntyre BC, Lowy AM. PMID: 17506250.
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A phase II study of sequential neoadjuvant gemcitabine and paclitaxel, radiation therapy with cisplatin and 5-fluorouracil and surgery in locally advanced esophageal carcinoma. Am J Clin Oncol. 2006 Dec; 29(6):555-61. Lowy AM, Firdaus I, Roychowdhury D, Redmond K, Howington JA, Sussman JJ, Safa M, Ahmad SA, Reed MF, Rose P, James L, Jazieh AR. PMID: 17148991.
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Cerebral edema in a patient following cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemoperfusion. World J Surg Oncol. 2006 Nov 30; 4:85. Nair RL, Tobias J, Stemmerman G, Lowy AM. PMID: 17137499; PMCID: PMC1697813.
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Sentinel lymph node biopsy in thin melanoma patients. J Surg Oncol. 2006 Mar 15; 93(4):279-85. Hershko DD, Robb BW, Lowy AM, Ahmad SA, Ramadas GH, Soldano DA, Sussman JJ. PMID: 16496355.
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Chronic pancreatitis: recent advances and ongoing challenges. Curr Probl Surg. 2006 Mar; 43(3):127-238. Ahmed SA, Wray C, Rilo HL, Choe KA, Gelrud A, Howington JA, Lowy AM, Matthews JB. PMID: 16530053.
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Putting the chemo in chemoradiation for pancreatic cancer. Ann Surg Oncol. 2006 Feb; 13(2):135-6. Lowy AM. PMID: 16411142.
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Forequarter amputation for recurrent breast cancer: a case report and review of the literature. J Surg Oncol. 2005 Nov 01; 92(2):134-41. Goodman MD, McIntyre B, Shaughnessy EA, Lowy AM, Ahmad SA. PMID: 16231376.
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Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis. J Am Coll Surg. 2005 Nov; 201(5):680-7. Ahmad SA, Lowy AM, Wray CJ, D'Alessio D, Choe KA, James LE, Gelrud A, Matthews JB, Rilo HL. PMID: 16256909.
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Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions. Pancreatology. 2005; 5(6):562-9. Wray CJ, Ahmad SA, Lowy AM, D'Alessio DA, Gelrud A, Choe KA, Soldano DA, Matthews JB, Rodriguez-Rilo HL. PMID: 16110254.
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Costs of treatment of Swiss patients with HIV on antiretroviral therapy in hospital-based and general practice-based care: a prospective cohort study. AIDS Care. 2005 Aug; 17(6):698-710. Lowy A, Page J, Jaccard R, Ledergerber B, Somaini B, Weber R, Szucs T. PMID: 16036256.
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Surgery for pancreatic cancer: recent controversies and current practice. Gastroenterology. 2005 May; 128(6):1626-41. Wray CJ, Ahmad SA, Matthews JB, Lowy AM. PMID: 15887155.
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The significance and clinical factors associated with a subcentimeter resection of colorectal liver metastases. Ann Surg Oncol. 2005 May; 12(5):374-80. Wray CJ, Lowy AM, Mathews JB, Park S, Choe KA, Hanto DW, James LE, Soldano DA, Ahmad SA. PMID: 15915371.
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Does size matter most? Reassessing clinical staging for pancreatic cancer. Ann Surg Oncol. 2005 Feb; 12(2):100-1. Lowy AM. PMID: 15827787.
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Pancreaticoduodenectomy. J Gastrointest Surg. 2005 Jan; 9(1):138-43. Ahmad SA, Lowy AM, McIntyre BC, Matthews JB. PMID: 15623455.
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Multiple focal nodular hyperplasia of the liver in a 21-year-old woman. J Gastrointest Surg. 2004 Jul-Aug; 8(5):591-5. Kim J, Nikiforov YE, Moulton JS, Lowy AM. PMID: 15239996.
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Reduced morbidity following cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion. Ann Surg Oncol. 2004 Apr; 11(4):387-92. Ahmad SA, Kim J, Sussman JJ, Soldano DA, Pennington LJ, James LE, Lowy AM. PMID: 15070598.
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Uncommon anal neoplasms. Surg Oncol Clin N Am. 2004 Apr; 13(2):375-88. Billingsley KG, Stern LE, Lowy AM, Kahlenberg MS, Thomas CR. PMID: 15137963.
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From bad to worse: prognostic factors in pancreatic cancer. Ann Surg Oncol. 2004 Feb; 11(2):117-8. Lowy AM. PMID: 14761910.
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An algorithm for the accurate identification of benign liver lesions. Am J Surg. 2004 Feb; 187(2):274-9. Kim J, Ahmad SA, Lowy AM, Buell JF, Pennington LJ, Moulton JS, Matthews JB, Hanto DW. PMID: 14769319.
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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 2003 Dec; 4(6):437-50. Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. PMID: 14706336.
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Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis. J Gastrointest Surg. 2003 Dec; 7(8):978-89. Rodriguez Rilo HL, Ahmad SA, D'Alessio D, Iwanaga Y, Kim J, Choe KA, Moulton JS, Martin J, Pennington LJ, Soldano DA, Biliter J, Martin SP, Ulrich CD, Somogyi L, Welge J, Matthews JB, Lowy AM. PMID: 14675707.
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Increased biliary fistulas after liver resection with the harmonic scalpel. Am Surg. 2003 Sep; 69(9):815-9. Kim J, Ahmad SA, Lowy AM, Buell JF, Pennington LJ, Soldano DA, James LE, Matthews JB, Hanto DW. PMID: 14509335.
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Ampullary carcinoid tumors: rationale for an aggressive surgical approach. J Gastrointest Surg. 2003 Sep-Oct; 7(6):773-6. Clements WM, Martin SP, Stemmerman G, Lowy AM. PMID: 13129555.
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Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors. Clin Colorectal Cancer. 2003 Aug; 3(2):113-20. Clements WM, Lowy AM, Groden J. PMID: 12952568.
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Technology of intraperitoneal chemotherapy administration: a survey of techniques with a review of morbidity and mortality. Surg Oncol Clin N Am. 2003 Jul; 12(3):849-63. Sarnaik AA, Sussman JJ, Ahmad SA, Lowy AM. PMID: 14567036.
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Osteoclast-like giant cell tumor of the pancreas associated with a mucinous cystadenocarcinoma. Surgery. 2003 Jun; 133(6):700-1. Sarnaik AA, Saad AG, Mutema GK, Martin SP, Attar A, Lowy AM. PMID: 12796742.
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Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma. Ann Surg Oncol. 2003 Apr; 10(3):284-90. Lowy AM, Fenoglio-Preiser C, Kim OJ, Kordich J, Gomez A, Knight J, James L, Groden J. PMID: 12679314.
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Duodenal gangliocytic paraganglioma with lymph node metastasis: a case report and review of the literature. Arch Pathol Lab Med. 2003 Mar; 127(3):e139-41. Sundararajan V, Robinson-Smith TM, Lowy AM. PMID: 12653602.
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Transgenic models of pancreatic cancer. Int J Gastrointest Cancer. 2003; 33(1):71-8. Lowy AM. PMID: 12909739.
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Pathologic quiz case: A 43-year-old woman with a subcutaneous mass in the upper arm. Arch Pathol Lab Med. 2003 Jan; 127(1):113-4. Gebrail F, Lowy A, Cualing H. PMID: 12562278.
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SMAD4 is a predictive marker for 5-fluorouracil-based chemotherapy in patients with colorectal cancer. Br J Cancer. 2002 Sep 09; 87(6):630-4. Boulay JL, Mild G, Lowy A, Reuter J, Lagrange M, Terracciano L, Laffer U, Herrmann R, Rochlitz C. PMID: 12237773; PMCID: PMC2364238.
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Restoration of E-cadherin/beta-catenin expression in pancreatic cancer cells inhibits growth by induction of apoptosis. Surgery. 2002 Aug; 132(2):141-8. Lowy AM, Knight J, Groden J. PMID: 12219004.
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beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res. 2002 Jun 15; 62(12):3503-6. Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J, Lowy AM. PMID: 12067995.
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Surgery as adjuvant therapy? The treatment of peritoneal metastases from gastrointestinal malignancy. Ann Surg Oncol. 2001 Dec; 8(10):754-5. Lowy AM. PMID: 11776486.
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Response shift in the perception of health for utility evaluation. an explorative investigation. Eur J Cancer. 2001 Sep; 37(14):1729-35. Bernhard J, Lowy A, Maibach R, Hürny C, Swiss Group for Clinical Cancer Research (SAKK) and the Swiss Institute for Applied Cancer Research . PMID: 11549425.
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Numerous colonic adenomas in an individual with Bloom's syndrome. Gastroenterology. 2001 Aug; 121(2):435-9. Lowy AM, Kordich JJ, Gismondi V, Varesco L, Blough RI, Groden J. PMID: 11487553.
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Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. Genes Chromosomes Cancer. 2001 Jul; 31(3):240-7. Boulay JL, Mild G, Reuter J, Lagrange M, Terracciano L, Lowy A, Laffer U, Orth B, Metzger U, Stamm B, Martinoli S, Herrmann R, Rochlitz C. PMID: 11391794.
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A pilot study of preoperative chemoradiotherapy for resectable gastric cancer. Ann Surg Oncol. 2001 Jul; 8(6):519-24. Lowy AM, Feig BW, Janjan N, Rich TA, Pisters PW, Ajani JA, Mansfield PF. PMID: 11456051.
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Features of primary care associated with variations in process and outcome of care of people with diabetes. Br J Gen Pract. 2001 May; 51(466):356-60. Khunti K, Ganguli S, Baker R, Lowy A. PMID: 11360698; PMCID: PMC1313998.
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A distinct splice form of APC is highly expressed in neurones but not commonly mutated in neuroepithelial tumours. J Med Genet. 2001 Apr; 38(4):257-62. Steigerwald K, Santoro IM, Kordich JJ, Gismondi V, Trzepacz C, Badiali M, Giangaspero F, Balko MG, Graham JS, Ratner N, Lowy AM, Varesco L, Groden J. PMID: 11370631; PMCID: PMC1734854.
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Inequalities in provision of systematic care for patients with diabetes. Fam Pract. 2001 Feb; 18(1):27-32. Khunti K, Ganguli S, Lowy A. PMID: 11145624.
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Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle. J Clin Endocrinol Metab. 2000 Nov; 85(11):4293-7. Lapsys NM, Kriketos AD, Lim-Fraser M, Poynten AM, Lowy A, Furler SM, Chisholm DJ, Cooney GJ. PMID: 11095470.
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Surgical management of hereditary pancreatic cancer. Med Clin North Am. 2000 May; 84(3):749-59. Davis B, Lowy AM. PMID: 10872430.
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Adjuvant/neoadjuvant chemoradiation for gastric and pancreatic cancer. Oncology (Williston Park). 1999 Oct; 13(10 Suppl 5):121-30. Lowy AM, Leach SD. PMID: 10550836.
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Pancreatic cancer: can we screen? How should we stage? Curr Gastroenterol Rep. 1999 Apr; 1(2):166-74. Parikh AA, Lowy AM. PMID: 10980945.
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Response to neoadjuvant chemotherapy best predicts survival after curative resection of gastric cancer. Ann Surg. 1999 Mar; 229(3):303-8. Lowy AM, Mansfield PF, Leach SD, Pazdur R, Dumas P, Ajani JA. PMID: 10077040; PMCID: PMC1191693.
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Survival following pancreaticoduodenectomy with resection of the superior mesenteric-portal vein confluence for adenocarcinoma of the pancreatic head. Br J Surg. 1998 May; 85(5):611-7. Leach SD, Lee JE, Charnsangavej C, Cleary KR, Lowy AM, Fenoglio CJ, Pisters PW, Evans DB. PMID: 9635805.
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Beta-blockers and antithrombotic treatment for secondary prevention after acute myocardial infarction. Towards an understanding of factors influencing clinical practice. The European Secondary Prevention Study Group. Eur Heart J. 1998 Jan; 19(1):74-9. Woods KL, Ketley D, Lowy A, Agusti A, Hagn C, Kala R, Karatzas NB, Leizorowicz A, Reikvam A, Schilling J, Seabra-Gomes R, Vasiliauskas D, Wilhelmsen L. PMID: 9503178.
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Prospective, randomized trial of octreotide to prevent pancreatic fistula after pancreaticoduodenectomy for malignant disease. Ann Surg. 1997 Nov; 226(5):632-41. Lowy AM, Lee JE, Pisters PW, Davidson BS, Fenoglio CJ, Stanford P, Jinnah R, Evans DB. PMID: 9389397; PMCID: PMC1191125.
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Phosphorylation of the tumor suppressor adenomatous polyposis coli (APC) by the cyclin-dependent kinase p34. J Biol Chem. 1997 Aug 29; 272(35):21681-4. Trzepacz C, Lowy AM, Kordich JJ, Groden J. PMID: 9268294.
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Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodenectomy for adenocarcinoma of the pancreas. J Clin Oncol. 1997 Mar; 15(3):928-37. Spitz FR, Abbruzzese JL, Lee JE, Pisters PW, Lowy AM, Fenoglio CJ, Cleary KR, Janjan NA, Goswitz MS, Rich TA, Evans DB. PMID: 9060530.
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Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem. 1996 Nov 15; 271(46):29380-5. Hao M, Lowy AM, Kapoor M, Deffie A, Liu G, Lozano G. PMID: 8910602.
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Reoperative pancreaticoduodenectomy for periampullary carcinoma. Am J Surg. 1996 Nov; 172(5):432-7; discussion 437-8. Robinson EK, Lee JE, Lowy AM, Fenoglio CJ, Pisters PW, Evans DB. PMID: 8942539.
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Association of gastric adenocarcinoma with the HLA class II gene DQB10301. Gastroenterology. 1996 Aug; 111(2):426-32. Lee JE, Lowy AM, Thompson WA, Lu M, Loflin PT, Skibber JM, Evans DB, Curley SA, Mansfield PF, Reveille JD. PMID: 8690208.
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Laparoscopic staging for gastric cancer. Surgery. 1996 Jun; 119(6):611-4. Lowy AM, Mansfield PF, Leach SD, Ajani J. PMID: 8650600.
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Clinical and preclinical trials of isolated liver perfusion for advanced liver tumors: primary liver tumors. Surg Oncol Clin N Am. 1996 Apr; 5(2):429-41. Lowy AM, Curley SA. PMID: 9019362.
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Preoperative infusional chemoradiation, selective intraoperative radiation, and resection for locally advanced pelvic recurrence of colorectal adenocarcinoma. Ann Surg. 1996 Feb; 223(2):177-85. Lowy AM, Rich TA, Skibber JM, Dubrow RA, Curley SA. PMID: 8597512; PMCID: PMC1235094.
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Gastric carcinoma. N Engl J Med. 1995 Nov 23; 333(21):1426-7; author reply 1428. Lowy AM, Mansfield PF. PMID: 7477137.
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Significance of peritoneal cytology in patients with potentially resectable adenocarcinoma of the pancreatic head. Surgery. 1995 Sep; 118(3):472-8. Leach SD, Rose JA, Lowy AM, Lee JE, Charnsangavej C, Abbruzzese JL, Katz RL, Evans DB. PMID: 7652681.
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Adjuvant therapy for resectable gastric adenocarcinoma: preoperative and postoperative chemotherapy trials. J Infus Chemother. 1995; 5(3):104-11. Leach SD, Lowy AM, Mansfield PF, Ajani JA. PMID: 8528966.
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Laparotomy in patients infected with human immunodeficiency virus: indications and outcome. Br J Surg. 1994 Jul; 81(7):942-5. Lowy AM, Barie PS. PMID: 7922084.
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Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3846-50. Sy MS, Lowy A, HayGlass K, Janeway CA, Gurish M, Greene MI, Benacerraf B. PMID: 6233614; PMCID: PMC345318.
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Genetically restricted antigen presentation for immunological tolerance and suppression. Nature. 1984 Mar 22-28; 308(5957):373-5. Lowy A, Drebin JA, Monroe JG, Granstein RD, Greene MI. PMID: 6231484.
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