David M. Reif, Ph.D. | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/ptb/staff/reif
Archived: 2026-04-23 17:16
David M. Reif, Ph.D. | National Institute of Environmental Health Sciences
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David M. Reif, Ph.D.
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Predictive Toxicology Branch
David M. Reif, Ph.D.
Chief, Predictive Toxicology Branch
Tel 984-287-3195
[email protected]
David M. Reif, Ph.D., joined the NIEHS in 2022 as Chief of the Predictive Toxicology Branch (PTB) in the Division of Translational Toxicology (DTT). In this role, he will leverage expertise of the branch in artificial intelligence / machine learning (AI/ML), data science, toxicogenomics, spatiotemporal exposures and toxicology, computational methods development, and new approach methods (NAMs) to advance predictive toxicology applications with partners across NIEHS, the interagency
Tox21 Program
and the
Interagency Coordinating Committee on the Validation of Alternative Methods
(ICCVAM).
Prior to joining NIEHS in 2022, Reif was a professor of bioinformatics at North Carolina State University, in the Department of Biological Sciences. His lab focused on integrated analysis of high-dimensional data from diverse sources to understand the complex interactions between human health and the environment and included trainees from degree programs in bioinformatics, genetics, toxicology, and statistics. Before North Carolina State University, David was a principal investigator (PI) with the U.S. EPA's National Center for Computational Toxicology. His efforts in research (
publications
), teaching, and outreach have been recognized with several honors, including the
Presidential Early Career Award for Scientists and Engineers
(PECASE), awarded by The White House as the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers. He has also been selected to serve on expert committees, including those for the National Academy of Sciences, the World Health Organization's International Agency for Research on Cancer, and the U.S. EPA Science Advisory Committee on Chemicals.
Reif earned his B.S. in biology (with a minor in finance) from the College of William and Mary, where he was a Monroe Scholar. He earned his M.S. in applied statistics and Ph.D. in human genetics from Vanderbilt University. He then completed postdoctoral training in exposure science and computational toxicology at the U.S EPA.
Recent Publications
Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.
Chemical research in toxicology
.
2026 Apr 20;39(4):624-635.
[
Abstract
Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study. Chemical research in toxicology. 2026 Apr 20
]
Luo X, Zhao J, Sakamuru S, Xia M, Xu T, Travers J, Klumpp-Thomas C, Zhu H, Hall M, Ferguson S, Reif D, Huang R. Integrating qHTS and QSAR Models to Identify Safe GPCR-Targeted Compounds: A Focus on hERG-Dependent Cardiotoxicity.
Journal of chemical information and modeling
.
2026 Mar 09;66(5):2474-2487.
[
Abstract
Luo X, Zhao J, Sakamuru S, Xia M, Xu T, Travers J, Klumpp-Thomas C, Zhu H, Hall M, Ferguson S, Reif D, Huang R. Integrating qHTS and QSAR Models to Identify Safe GPCR-Targeted Compounds: A Focus on hERG-Dependent Cardiotoxicity. Journal of chemical information and modeling. 2026 Mar 09
]
Luo X, Zhang L, Sakamuru S, Adesina P, Zhao J, Xia M, Xu T, Ngan D, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson S, Zhu H, Hall M, Reif D, Huang R. Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
Toxicology and applied pharmacology
.
2025 Sep 14;505:117567.
[
Abstract
Luo X, Zhang L, Sakamuru S, Adesina P, Zhao J, Xia M, Xu T, Ngan D, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson S, Zhu H, Hall M, Reif D, Huang R. Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity. Toxicology and applied pharmacology. 2025 Sep 14
]
Boatman A, Chappel J, Kirkwood-Donelson K, Fleming J, Reif D, Schymanski E, Rager J, Baker E. Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.
Environmental science & technology
.
2025 Aug 26;59(33):17711-17721.
[
Abstract
Boatman A, Chappel J, Kirkwood-Donelson K, Fleming J, Reif D, Schymanski E, Rager J, Baker E. Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry. Environmental science & technology. 2025 Aug 26
]
Sakamuru S, Travers J, Klumpp-Thomas C, Huang R, Witt K, Ferguson S, Simmons S, Reif D, Simeonov A, Xia M. Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes.
International journal of molecular sciences
.
2025 May 22;26(11):.
[
Abstract
Sakamuru S, Travers J, Klumpp-Thomas C, Huang R, Witt K, Ferguson S, Simmons S, Reif D, Simeonov A, Xia M. Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes. International journal of molecular sciences. 2025 May 22
]
More Recent Publications from PubMed
Related Links
Comparing the Potential Health Effects of Chemicals
- Environmental Factor, February 2024
Scientists Talk Precision Medicine, Environmental Health at NC Event
- Environmental Factor, June 2023
Scientific Journeys: From Genetics to the Environment and Back
- Environmental Factor, April 2023
Back
to Top
Last Reviewed: December 19, 2025
Skip Navigation
David M. Reif, Ph.D.
Close the left navigation
Add
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Predictive Toxicology Branch
David M. Reif, Ph.D.
Chief, Predictive Toxicology Branch
Tel 984-287-3195
[email protected]
David M. Reif, Ph.D., joined the NIEHS in 2022 as Chief of the Predictive Toxicology Branch (PTB) in the Division of Translational Toxicology (DTT). In this role, he will leverage expertise of the branch in artificial intelligence / machine learning (AI/ML), data science, toxicogenomics, spatiotemporal exposures and toxicology, computational methods development, and new approach methods (NAMs) to advance predictive toxicology applications with partners across NIEHS, the interagency
Tox21 Program
and the
Interagency Coordinating Committee on the Validation of Alternative Methods
(ICCVAM).
Prior to joining NIEHS in 2022, Reif was a professor of bioinformatics at North Carolina State University, in the Department of Biological Sciences. His lab focused on integrated analysis of high-dimensional data from diverse sources to understand the complex interactions between human health and the environment and included trainees from degree programs in bioinformatics, genetics, toxicology, and statistics. Before North Carolina State University, David was a principal investigator (PI) with the U.S. EPA's National Center for Computational Toxicology. His efforts in research (
publications
), teaching, and outreach have been recognized with several honors, including the
Presidential Early Career Award for Scientists and Engineers
(PECASE), awarded by The White House as the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers. He has also been selected to serve on expert committees, including those for the National Academy of Sciences, the World Health Organization's International Agency for Research on Cancer, and the U.S. EPA Science Advisory Committee on Chemicals.
Reif earned his B.S. in biology (with a minor in finance) from the College of William and Mary, where he was a Monroe Scholar. He earned his M.S. in applied statistics and Ph.D. in human genetics from Vanderbilt University. He then completed postdoctoral training in exposure science and computational toxicology at the U.S EPA.
Recent Publications
Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.
Chemical research in toxicology
.
2026 Apr 20;39(4):624-635.
[
Abstract
Ngan D, Ye L, Hsieh J, Xu T, Zhao J, Sakamuru S, Tao D, LeClair C, Zhao T, Rossoshek A, Reif D, Simeonov A, Xia M, Huang R. Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study. Chemical research in toxicology. 2026 Apr 20
]
Luo X, Zhao J, Sakamuru S, Xia M, Xu T, Travers J, Klumpp-Thomas C, Zhu H, Hall M, Ferguson S, Reif D, Huang R. Integrating qHTS and QSAR Models to Identify Safe GPCR-Targeted Compounds: A Focus on hERG-Dependent Cardiotoxicity.
Journal of chemical information and modeling
.
2026 Mar 09;66(5):2474-2487.
[
Abstract
Luo X, Zhao J, Sakamuru S, Xia M, Xu T, Travers J, Klumpp-Thomas C, Zhu H, Hall M, Ferguson S, Reif D, Huang R. Integrating qHTS and QSAR Models to Identify Safe GPCR-Targeted Compounds: A Focus on hERG-Dependent Cardiotoxicity. Journal of chemical information and modeling. 2026 Mar 09
]
Luo X, Zhang L, Sakamuru S, Adesina P, Zhao J, Xia M, Xu T, Ngan D, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson S, Zhu H, Hall M, Reif D, Huang R. Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity.
Toxicology and applied pharmacology
.
2025 Sep 14;505:117567.
[
Abstract
Luo X, Zhang L, Sakamuru S, Adesina P, Zhao J, Xia M, Xu T, Ngan D, Travers J, Wood S, Sukhawanit R, Garrison A, Klumpp-Thomas C, Ferguson S, Zhu H, Hall M, Reif D, Huang R. Systematic evaluation of Tox21 compounds that target β-adrenergic receptors and their role in cardiotoxicity. Toxicology and applied pharmacology. 2025 Sep 14
]
Boatman A, Chappel J, Kirkwood-Donelson K, Fleming J, Reif D, Schymanski E, Rager J, Baker E. Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry.
Environmental science & technology
.
2025 Aug 26;59(33):17711-17721.
[
Abstract
Boatman A, Chappel J, Kirkwood-Donelson K, Fleming J, Reif D, Schymanski E, Rager J, Baker E. Updated Guidance for Communicating PFAS Identification Confidence with Ion Mobility Spectrometry. Environmental science & technology. 2025 Aug 26
]
Sakamuru S, Travers J, Klumpp-Thomas C, Huang R, Witt K, Ferguson S, Simmons S, Reif D, Simeonov A, Xia M. Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes.
International journal of molecular sciences
.
2025 May 22;26(11):.
[
Abstract
Sakamuru S, Travers J, Klumpp-Thomas C, Huang R, Witt K, Ferguson S, Simmons S, Reif D, Simeonov A, Xia M. Profiling the Tox21 Compound Library for Their Inhibitory Effects on Cytochrome P450 Enzymes. International journal of molecular sciences. 2025 May 22
]
More Recent Publications from PubMed
Related Links
Comparing the Potential Health Effects of Chemicals
- Environmental Factor, February 2024
Scientists Talk Precision Medicine, Environmental Health at NC Event
- Environmental Factor, June 2023
Scientific Journeys: From Genetics to the Environment and Back
- Environmental Factor, April 2023
Back
to Top
Last Reviewed: December 19, 2025