Developmental Neurotoxicity Screening Assay Chemical List | National Institute of Environmental Health Sciences

Developmental Neurotoxicity Screening Assay Chemical List | National Institute of Environmental Health Sciences
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Table of Contents
Phase 1 (2021) - 115 Chemicals
Phase 2 (2023) - 108 Chemicals
Phase 1 (2021) - 115 Chemicals
CASRN
DTXSID
Chemical Name
Category
NOCAS_09864
DTXSID801336159
Fu Zi (Zhi) (Aconitum Lateralis) root extract1
Botanical
8063-12-5
DTXSID901018461
Aconite Root Straight Powder1
Botanical
NOCAS_09845
DTXSID301334841
Bupleurum2
Botanical
NOCAS_09845
DTXSID301334841
Bupleurum Root Powder2
Botanical
NOCAS_09845
DTXSID301334841
Bupleurum Root Straight Powder2
Botanical
NOCAS_09844
DTXSID101336160
Guarana3
Botanical
84929-28-2
DTXSID501018738
Guarana Extract3
Botanical
84929-28-2
DTXSID501018738
Guarana Seed 22%3
Botanical
NOCAS_09844
DTXSID001335119
Guarana Seed Powder3
Botanical
NOCAS_09857
DTXSID001334842
Kratom Leaf Straight Powder4
Botanical
NOCAS_09857
DTXSID001334842
Kratom Whole Dry Leaf (Lot 1142201210)4
Botanical
NOCAS_09857
DTXSID001334842
Kratom Whole Dry Leaf (Lot 1110201210)4
Botanical
NOCAS_09853
DTXSID701334843
Wormwood5
Botanical
NOCAS_09885
DTXSID301335118
Wormwood Herb 10:1 5
Botanical
NOCAS_09853
DTXSID601335117
Wormwood HERB Powder Organic5
Botanical
NOCAS_09853
DTXSID601335117
Wormwood Powder5
Botanical
85117-22-2
DTXSID4032291
Yohimbe Bark 8%6
Botanical
85117-22-2
DTXSID4032291
Yohimbe Bark Extract6
Botanical
85117-22-2
DTXSID4032291
Yohimbe Extract6
Botanical
85117-22-2
DTXSID4032291
Yohimbe Extract 450 mg6
Botanical
50-81-7
DTXSID5020106
L-ascorbic acid
Negative Control
82385-42-0
DTXSID7021992
Saccharin Sodium hydrate
Negative Control
115-09-3
DTXSID5020813
Methyl mercuric chloride
Positive Control
83-79-4
DTXSID6021248
Rotenone
Positive Control
320-67-2
DTXSID9020116
5-Azacytidine
Drug
134523-03-8
DTXSID6044303
Atorvastatin calcium salt
Drug
15663-27-1
DTXSID4024983
Cisplatin
Drug
69-74-9
DTXSID5024891
Cytarabine hydrochloride
Drug
1051375-16-6
DTXSID90909356
Dolutegravir
Drug
84371-65-3
DTXSID5023322
Mifepristone
Drug
6153-64-6
DTXSID4023412
Oxytetracycline dihydrate
Drug
25637-99-4
DTXSID8025383
Hexabromocyclododecane (HBCD)
Flame Retardant
13674-84-5
DTXSID5026259
Tris (chloropropyl) phosphate
Flame Retardant
131860-33-8
DTXSID0032520
Azoxystrobin
Fungicide
188425-85-6
DTXSID6034392
Boscalid
Fungicide
10605-21-7
DTXSID4024729
Carbendazim
Fungicide
120116-88-3
DTXSID9034492
Cyazofamid
Fungicide
131807-57-3
DTXSID8034588
Famoxadone
Fungicide
79622-59-6
DTXSID7032551
Fluazinam
Fungicide
361377-29-9
DTXSID2034625
Fluoxastrobin
Fungicide
143390-89-0
DTXSID2032558
Kresoxim-methyl
Fungicide
117428-22-5
DTXSID9047542
Picoxystrobin
Fungicide
12071-83-9
DTXSID1052741
Propineb
Fungicide
178928-70-6
DTXSID4034869
Prothioconazole
Fungicide
175013-18-0
DTXSID7032638
Pyraclostrobin
Fungicide
137-26-8
DTXSID5021332
Thiram
Fungicide
43121-43-3
DTXSID3023897
Triadimefon
Fungicide
141517-21-7
DTXSID4032580
Trifloxystrobin
Fungicide
50471-44-8
DTXSID4022361
Vinclozolin
Fungicide
94-75-7
DTXSID0020442
2,4-Dichlorophenoxy acetic acid (2,4-D)
Herbicide
129909-90-6
DTXSID3034329
Amicarbazone (MKH 3586)
Herbicide
741-58-2
DTXSID9032329
Bensulide
Herbicide
20243-81-6
DTXSID2037500
Bensulide oxon
Herbicide
105512-06-9
DTXSID6032354
Clodinafop-propargyl (CGA-184927)
Herbicide
CASRN
DTXSID
Chemical Name
Category
759-94-4
DTXSID1024091
EPTC (S-Ethyl dipropylthiocarbamate)
Herbicide
55283-68-6
DTXSID8032386
Ethalfluralin
Herbicide
141112-29-0
DTXSID5034723
Isoxaflutole
Herbicide
29450-45-1
DTXSID5034698
MCPA.EHE (2-ethyl hexyl ester)
Herbicide
104206-82-8
DTXSID7032424
Mesotrione
Herbicide
2212-67-1
DTXSID6024206
Molinate
Herbicide
42874-03-3
DTXSID7024241
Oxyfluorfen
Herbicide
365400-11-9
DTXSID2044343
Pyrasulfotole (AE 0317309)
Herbicide
447399-55-5
DTXSID4058104
Pyroxasulfone (KIH-485)
Herbicide
78-48-8
DTXSID1024174
Tribufos
Herbicide
31142-56-0
DTXSID3030711
Aluminum citrate
Industrial
95-16-9
DTXSID7024586
Benzothiazole
Industrial
85-68-7
DTXSID3020205
Benzyl butyl phthalate
Industrial
117-81-7
DTXSID5020607
Di(2-ethylhexyl) phthalate
Industrial
84-74-2
DTXSID2021781
Di(n-butyl) phthalate
Industrial
84-69-5
DTXSID9022522
Diisobutyl phthalate
Industrial
100-41-4
DTXSID3020596
Ethylbenzene
Industrial
67-63-0
DTXSID7020762
Isopropanol
Industrial
3622-84-2
DTXSID7027540
N-Butylbenzenesulfonamide
Industrial
159989-65-8
DTXSID2033736
Nelfinavir mesylate
Industrial
563-68-8
DTXSID6024331
Thallium (I) acetate
Industrial
126-73-8
DTXSID3021986
Tributyl phosphate (TNBP)
Industrial
112-35-6
DTXSID5026912
Triethylene Glycol Monomethyl Ether (TGME)
Industrial
13252-13-6
DTXSID70880215
GenX (HFPO-DA/ hexafluoropropylene oxide dimer acid
Industrial-PFAS
375-73-5
DTXSID5030030
Perfluorobutanesulfonic acid (PFBS)
Industrial-PFAS
3871-99-6
DTXSID3037709
Perfluorohexanesulfonic acid potassium salt (PFHSKslt)
Industrial-PFAS
1763-23-1
DTXSID3031864
Perfluorooctanesulfonic acid (PFOS)
Industrial-PFAS
335-67-1
DTXSID8031865
Perfluorooctanoic acid (PFOA)
Industrial-PFAS
134-62-3
DTXSID2021995
DEET
Insect repellant
105726-67-8
DTXSID5032440
N-Methylneodecanamide (MNDA)
Insect repellant
3564-98-5
DTXSID5035084
p-methane-3,8-diol (Cyclohexanemethanol)
Insect repellant
71751-41-2
DTXSID8023892
Abamectin 1 and 2
Insecticide
68359-37-5
DTXSID5035957
Baythroid
Insecticide
82657-04-3
DTXSID9020160
Bifenthrin
Insecticide
1563-66-2
DTXSID9020249
Carbofuran
Insecticide
54593-83-8
DTXSID2032344
Chlorethoxyfos
Insecticide
3957-63-9
DTXSID7037509
Chlorethoxyfos oxon
Insecticide
122453-73-0
DTXSID9032533
Chlorfenapyr
Insecticide
1315501-18-8
DTXSID40274167
Cypermethrin zeta
Insecticide
962-58-3
DTXSID5037523
Diazoxon
Insecticide
62-73-7
DTXSID5020449
Dichlorvos (DDVP)
Insecticide
155569-91-8
DTXSID0034566
Emamectin benzoate
Insecticide
13194-48-4
DTXSID4032611
Ethoprop
Insecticide
22224-92-6
DTXSID3024102
Fenamiphos
Insecticide
111812-58-9
DTXSID2032550
Fenpyroximate (Z,E)
Insecticide
69770-45-2
DTXSID8058166
Flumethrin
Insecticide
300-76-5
DTXSID1024209
Naled
Insecticide
298-02-2
DTXSID4032459
Phorate
Insecticide
2600-69-3
DTXSID4037586
Phorate oxon
Insecticide
732-11-6
DTXSID5024261
Phosmet
Insecticide
3735-33-9
DTXSID6042286
Phosmet oxon
Insecticide
96489-71-3
DTXSID5032573
Pyridaben
Insecticide
96182-53-5
DTXSID1032482
Tebupirimfos
Insecticide
1035330-36-9
DTXSID5037602
Tebupirimphos oxon (OMAT)
Insecticide
13071-79-9
DTXSID2022254
Terbufos
Insecticide
56070-14-5
DTXSID0037601
Terbufos oxon
Insecticide
10548-10-4
DTXSID6042444
Terbufos sulfoxide
Insecticide
22248-79-9
DTXSID1032648
Tetrachlorvinphos
Insecticide
118712-89-3
DTXSID4046812
Transfluthrin
Insecticide
997-55-7
DTXSID40897219
N-Acetyl-L-aspartic acid
Miscellaneous
994-36-5
DTXSID1027348
Sodium citrate
Miscellaneous
1
Aconite (Aconitum spp)
2
Bupleurum (Bupleurum chinensis)
3
Guarana (Paullinia cupana)
4
Kratom (Mitragyna speciosa)
5
Wormwood (Artemisia absinthium L.)
6
Yohimbe (Pausinystalia yohimbe)
Stock solvents: dimethyl sulfoxide (DMSO) or water (if insoluble DMSO).
Stock concentrations: target is 100 mM but ≤ 100 mM depending on solubility with 20 mM minimum except for botanicals.
For botanicals the molecular weight is unknown; stock concentrations range from 0.7 to 65 mg/mL.
Phase 2 (2023) - 108 Chemicals
CASRN
DTXSID
Chemical Name
Category
50-81-7
DTXSID5020106
L-Ascorbic acid
Neg Control
81-81-2
DTXSID5023742
Warfarin
Neg Control
34552-83-5
DTXSID00880006
Loperamide hydrochloride
Neg Control
73590-58-6
DTXSID6021080
Omeprazole
Neg Control
14611-52-0
DTXSID9044584
Selegiline hydrochloride
Neg Control
103-90-2
DTXSID2020006
Acetaminophen (4-hydroxyacetanilide) (paracetamol)
Neg Control
62571-86-2
DTXSID1037197
Captopril
Neg Control
69-65-8
DTXSID1023235
D-Mannitol
Neg Control
486-56-6
DTXSID1047576
Cotinine
Neg Control
132-98-9
DTXSID7021102
Penicillin VK
Neg Control
69-53-4
DTXSID4022602
Ampicillin
Neg Control
114-07-8
DTXSID4022991
Erythromycin
Neg Control
127-69-5
DTXSID6021292
Sulfisoxazole
Neg Control
108-95-2
DTXSID5021124
Phenol
Neg Control
1772-03-8
DTXSID4031356
Galactosamine hydrochloride
Neg Control
133-90-4
DTXSID2020262
Chloramben
Neg Control
111-46-6
DTXSID8020462
Diethylene glycol
Neg Control
54-11-5
DTXSID1020930
Nicotine
Pos Control
75365-73-0
DTXSID001044510
Paraquat dichloride hydrate
Pos Control
120983-64-4
DTXSID3044338
Prothioconazole-desthio
Pos Control
365400-11-9
DTXSID2044343
Pyrasulfotole (AE 0317309)
Pos Control
92456-72-9
DTXSID301019166
Cassava (
Manihot esculenta
) leaf extract
Botanical
84929-39-5
DTXSID201042091
oleander (Nerium oleander L)
Botanical
554-35-8
DTXSID8052857
Linamarin
Botanical, component
1244-58-2
DTXSID80154318
Cannabidiolic acid
Cannabinoid
24274-48-4
DTXSID801019159
Cannabidivarin
Cannabinoid
25654-31-3
DTXSID701014168
Cannabigerol
Cannabinoid
25555-57-1
DTXSID401315426
Cannabigerolic acid
Cannabinoid
521-35-7
DTXSID3048996
cannabinol
Cannabinoid
13956-29-1
DTXSID00871959
Cannabidiol
Cannabinoid
20675-51-8
DTXSID80942873
Cannabichromene
Cannabinoid
185505-15-1
DTXSID301336859
(+,-) Cannabichromenic acid
Cannabinoid
5957-75-5
DTXSID20878586
Δ8-tetrahydrocannabinol
Cannabinoid
1972-08-3
DTXSID6021327
Δ9-tetrahydrocannabinol
Cannabinoid
31262-37-0
DTXSID10893920
Tetrahydrocannabivarin
Cannabinoid
23978-85-0
DTXSID30178701
Tetrahydrocannabinolic acid-A
Cannabinoid
95543-62-7
DTXSID401038856
(9R) Δ10-tetrahydrocannabinol
Cannabinoid
58-08-2
DTXSID0020232
Caffeine
Drug
7681-49-4
DTXSID2020630
Sodium fluoride
Drug
134678-17-4
DTXSID7023194
Lamivudine
Drug
58-55-9
DTXSID5021336
Theophylline
Drug
33419-42-0
DTXSID5023035
Etoposide
Drug
7220-79-3
DTXSID0025600
Methylene blue trihydrate
Drug
532-32-1
DTXSID1020140
Sodium benzoate
Drug, Food
Additive
5897-16-5
DTXSID70207706
Calcium cyclamate dihydrate
Food
Additive
94-49-5
DTXSID60877972
Ethylene dibenzoate
Food
Additive
80863-62-3
DTXSID3043780
Alitame
Food
Additive
82385-42-0
DTXSID7021992
Sodium Saccharin hydrate
Food
Additive
25956-17-6
DTXSID4024436
Allura Red C.I. 16035 (FD&C Red No. 40)
Food dye
1934-21-0
DTXSID1021455
FD&C Yellow No. 5 (Tartrazine)
Food dye
16423-68-0
DTXSID7021233
FD&C Red No. 3 (Erythrosine)
Food dye
2783-94-0
DTXSID6021456
FD&C Yellow No. 6 (Sunset Yellow FCF)
Food dye
3844-45-9
DTXSID2020189
FD&C Blue No. 1 (Brilliant Blue FCF)
Food dye
860-22-0
DTXSID1020190
FD&C Blue No. 2 (Indigo carmine)
Food dye
2353-45-9
DTXSID3020673
FD&C Green No. 3 (Fast Green FCF)
Food dye
67306-00-7
DTXSID9058157
Fenpropidin
Fungicide
149961-52-4
DTXSID3057981
Dimoxystrobin
Fungicide
81591-81-3
DTXSID5034939
Glyphosate trimesium
Herbicide
950782-86-2
DTXSID0058223
Indaziflam (BCS-AA10717)
Herbicide
951659-40-8
DTXSID10872811
Flupyradifurone (BYI 02960)
Insecticide
33089-61-1
DTXSID5023871
Amitraz
Insecticide
120738-89-8
DTXSID3058292
Nitenpyram
Insecticide
39515-41-8
DTXSID0024002
Fenpropathrin
Insecticide
39515-40-7
DTXSID4032536
Cyphenothrin
Insecticide
13410-01-0
DTXSID5032076
Sodium selenate
Insecticide
100-42-5
DTXSID2021284
Styrene
Industrial
103-23-1
DTXSID0020606
Bis(2-Ethylhexyl) adipate
Industrial
75-25-2
DTXSID1021374
Tribromomethane (Bromoform)
Industrial
2451-62-9
DTXSID4026262
Triglycidyl isocyanurate
Industrial
288-88-0
DTXSID6027131
1,2,4-Triazole
Industrial
101-14-4
DTXSID5020865
4,4'-Methylene bis(2-chloroaniline)
Industrial
140-66-9
DTXSID9022360
4-tert-Octylphenol (4-(1,1,3,3-
Tetramethylbutyl)-phenol)
Industrial
17540-75-9
DTXSID8029315
4-sec-Butyl-2,6-di-tert-butylphenol
Industrial
91-94-1
DTXSID6020432
3,3'-Dichlorobenzidine
Industrial, dyes
612-83-9
DTXSID1020433
3,3'-Dichlorobenzidine dihydrochloride
Industrial, dyes
183658-27-7
DTXSID9052686
2-Ethylhexyl 2,3,4,5- tetrabromobenzoate (TBB)
Industrial,
Flame
retardant
3278-89-5
DTXSID3044918
1,3,5-Tribromo-2-(prop-2-en-1yloxy)benzene
Industrial
Flame
retardant
10034-96-5
DTXSID4020795
Manganese (II) sulfate monohydrate
Metal
10026-24-1
DTXSID7020340
Cobalt sulfate heptahydrate
Metal
10101-97-0
DTXSID7020928
Nickel sulfate hexahydrate
Metal
10108-64-2
DTXSID6020226
Cadmium chloride
Metal,
Pos control
60-57-1
DTXSID9020453
Dieldrin
Mixture*
5436-43-1
DTXSID3030056
2,2',4,4'-Tetrabromodiphenyl ether
(BDE-47)
Mixture*
107534-96-3
DTXSID9032113
Tebuconazole
Mixture*
80-05-7
DTXSID7020182
Bisphenol A (BPA)
Mixture*
2921-88-2
DTXSID4020458
Chlorpyrifos
Mixture*
70-30-4
DTXSID6020690
Hexachlorophene
Mixture*
115-09-3
DTXSID5020813
Methyl mercuric (II) chloride
Mixture*
79-06-1
DTXSID5020027
Acrylamide
Mixture*
NOCAS_
1354859
DTXSID101354859
Dieldrin + BDE-47 (2:1 molarity (Dieldrin:BDE-47))
Mixture*
NOCAS_
1354860
DTXSID401354860
Tebuconazole + Chlorpyrifos (10:1 molarity (Tebuconazole:Chlorpyrifos))
Mixture*
NOCAS_
1354861
DTXSID101354861
Hexachlorophene + Methyl mercuric
(II) chloride (1:5 molarity
(Hexachlorophene :Methyl mercuric (II)
chloride))
Mixture*
NOCAS_
1354862
DTXSID801354862
Bisphenol A + Acrylamide (1:10 molarity (Bisphenol A:Acrylamide))
Mixture*
NOCAS_
1354863
DTXSID501354863
BDE-47 + Chlorpyrifos (5:1 molarity (BDE-47:Chlorpyrifos))
Mixture*
NOCAS_
1354864
DTXSID201354864
BDE-47 + Methyl mercuric (II) chloride
(2:1 molarity (BDE-47:Methyl mercuric
(II) chloride))
Mixture*
NOCAS_
1354865
DTXSID901354865
BDE-47 + Bisphenol A (1:1 molarity (BDE-47:Bisphenol A))
Mixture*
NOCAS_
1354866
DTXSID601354866
Methyl mercuric (II) chloride + Chlorpyrifos (1:10 molarity (Methyl mercuric (II) chloride:Chlorpyrifos))
Mixture*
NOCAS_
1354867
DTXSID301354867
Methyl mercuric (II) chloride + Bisphenol A (1:100 molarity (Methyl mercuric (II) chloride:Bisphenol A))
Mixture*
NOCAS_
1354868
DTXSID001354868
CEM ratio 1 (1:1:1:1:1:1:1:1 molarity of Dieldrin:BDE47:Tebuconazole:Chlorpyrifos: Hexachlorophene :Methyl mercuric (II) chloride: Bisphenol A: Acrylamide)
Mixture*
NOCAS_
1354869
DTXSID701354869
CEM ratio 2 (1:10:20:100:5:5:10:200 molarity of Dieldrin:BDE-47:Tebuconazole: Chlorpyrifos:Hexachlorophene:Methyl mercuric (II) chloride: Bisphenol A:
Acrylamide)
Mixture*
NOCAS_
1354870
DTXSID001354870
CEM ratio 3 (10:10:20:10:1:1:10:20 molarity of Dieldrin:BDE-47:Tebuconazole: Chlorpyrifos:Hexachlorophene :Methyl mercuric (II) chloride: Bisphenol A:
Acrylamide)
Mixture*
376-90-9
DTXSID3059927
Hexafluoroamylene glycol
PFAS
336-08-3
DTXSID4059833
Perfluorohexanedioic acid
PFAS
422-05-9
DTXSID4059966
2:1 Fluorotelomer alcohol
PFAS
2706-90-3
DTXSID6062599
Perfluoropentanoic acid (PFPeA)
PFAS
375-22-4
DTXSID4059916
Perfluorobutanoic acid (PFBA)
PFAS
749836-
20-2
DTXSID10892352
Perfluoro-2-{[perfluoro-3-(perfluoroethoxy)-2propanyl]oxy}ethanesulfonic acid (Nafion byproduct 2)
PFAS
29311-67-
9
DTXSID30892354
Perfluoro-3,6-dioxa-4-methyl-7-octene-1sulfonic acid (Nafion by-product 1)
PFAS
1
Mixture* = Mixture or mixture component
2
Linamarin is a botanical component of Cassava.
3
Manihot esculenta
is an alternate name for Manihot ultilissima which are both synonyms for the U.S. Plant Database name for Cassava, Manihot esculenta Crantz.
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Last Reviewed: February 03, 2026