Comparative & Molecular Pathogenesis Branch | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/cmp
Archived: 2026-04-23 17:22
Comparative & Molecular Pathogenesis Branch | National Institute of Environmental Health Sciences
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
The Comparative and Molecular Pathogenesis Branch (CMPB) provides toxicologic pathology leadership and laboratory animal medicine expertise to meet the goals of the NIEHS
Division of Translational Toxicology
(DTT) using new technologies in biomedical research. DTT is a team-based scientific organization, and its mission is to improve public health through development of data and knowledge that are translatable, predictive, and timely.
A major function of the Branch is to provide a translational and mechanistic context to pathology outcomes with the integration of scientific data across all DTT branches and offices. In addition, CMPB trains pathology and laboratory animal medicine fellows to be leaders in multidisciplinary research.
CMPB scientists and staff are responsible for the following general functions:
Developing and sharing educational and training materials that enhance the understanding and practice of toxicologic pathology with the international community through the publicly available online
DTT Global Toxicologic Pathology Training Program
.
Developing new methods, approaches, and technologies in pathology and laboratory animal medicine.
Directing, managing, evaluating, and interpreting all pathology data generated during the conduct of DTT toxicity and carcinogenicity studies.
Directing the DTT laboratory animal medicine program.
Establishing standards, terminology, and diagnostic criteria for rodent pathology (
NTP Nonneoplastic Lesion Atlas
).
Investigating molecular mechanisms of spontaneous and chemically induced nonneoplastic and neoplastic lesions in DTT studies.
Leading state-of the-science core pathology laboratories which include:
Clinical chemistry
Electron Microscopy
Hematology
Histology
Imaging Sciences/Artificial Intelligence
Immunohistochemistry
Laser Capture Microdissection
Mouse Embryo Phenotyping
Necropsies
Overseeing the scientific activities of the DTT archives and frozen tissue bank.
Providing diagnostic pathology expertise and collaborations with NIEHS investigators and the NIEHS laboratory animal colony.
CMPB is organized into eight scientific groups that are led by board certified pathologists and laboratory animal medicine scientists, and fellows of the International Academy of Toxicologic Pathology.
Clinical Pathology Group
Comparative Medicine Group
Imaging Sciences and Artificial Intelligence Group
Laser Capture Microdissection Group
Molecular Pathology Group
Mouse Embryo Phenotyping and Special Techniques Group
Pathology Evaluation and Peer Review Group
Pathology Support Group
CMPB scientists contribute to
NTP report and monograph series
and publish findings in the
NIEHS report series
and peer-reviewed scientific literature.
Staff publications can be viewed on the webpage
.
Chief
Robert C. Sills, D.V.M., Ph.D.
Chief, Comparative and Molecular Pathogenesis Branch
Tel 984-287-3839
[email protected]
Related Links
Global Toxicologic Pathology Training Program
NTP Nonneoplastic Lesion Atlas
NTP Rodent Ultrastructure Atlas
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to Top
Last Reviewed: February 19, 2026
Skip Navigation
Comparative & Molecular Pathogenesis Branch
Close the left navigation
Add
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
The Comparative and Molecular Pathogenesis Branch (CMPB) provides toxicologic pathology leadership and laboratory animal medicine expertise to meet the goals of the NIEHS
Division of Translational Toxicology
(DTT) using new technologies in biomedical research. DTT is a team-based scientific organization, and its mission is to improve public health through development of data and knowledge that are translatable, predictive, and timely.
A major function of the Branch is to provide a translational and mechanistic context to pathology outcomes with the integration of scientific data across all DTT branches and offices. In addition, CMPB trains pathology and laboratory animal medicine fellows to be leaders in multidisciplinary research.
CMPB scientists and staff are responsible for the following general functions:
Developing and sharing educational and training materials that enhance the understanding and practice of toxicologic pathology with the international community through the publicly available online
DTT Global Toxicologic Pathology Training Program
.
Developing new methods, approaches, and technologies in pathology and laboratory animal medicine.
Directing, managing, evaluating, and interpreting all pathology data generated during the conduct of DTT toxicity and carcinogenicity studies.
Directing the DTT laboratory animal medicine program.
Establishing standards, terminology, and diagnostic criteria for rodent pathology (
NTP Nonneoplastic Lesion Atlas
).
Investigating molecular mechanisms of spontaneous and chemically induced nonneoplastic and neoplastic lesions in DTT studies.
Leading state-of the-science core pathology laboratories which include:
Clinical chemistry
Electron Microscopy
Hematology
Histology
Imaging Sciences/Artificial Intelligence
Immunohistochemistry
Laser Capture Microdissection
Mouse Embryo Phenotyping
Necropsies
Overseeing the scientific activities of the DTT archives and frozen tissue bank.
Providing diagnostic pathology expertise and collaborations with NIEHS investigators and the NIEHS laboratory animal colony.
CMPB is organized into eight scientific groups that are led by board certified pathologists and laboratory animal medicine scientists, and fellows of the International Academy of Toxicologic Pathology.
Clinical Pathology Group
Comparative Medicine Group
Imaging Sciences and Artificial Intelligence Group
Laser Capture Microdissection Group
Molecular Pathology Group
Mouse Embryo Phenotyping and Special Techniques Group
Pathology Evaluation and Peer Review Group
Pathology Support Group
CMPB scientists contribute to
NTP report and monograph series
and publish findings in the
NIEHS report series
and peer-reviewed scientific literature.
Staff publications can be viewed on the webpage
.
Chief
Robert C. Sills, D.V.M., Ph.D.
Chief, Comparative and Molecular Pathogenesis Branch
Tel 984-287-3839
[email protected]
Related Links
Global Toxicologic Pathology Training Program
NTP Nonneoplastic Lesion Atlas
NTP Rodent Ultrastructure Atlas
Back
to Top
Last Reviewed: February 19, 2026