Serological Surveillance for COVID-19 in Central North Carolina | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/crb/studies/closed-studies/covid
Archived: 2026-04-23 17:22
Serological Surveillance for COVID-19 in Central North Carolina | National Institute of Environmental Health Sciences
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Study Background
This study is no longer accepting participants.
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ClinicalTrials.gov
NIH Clinical Studies
It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-CoV-2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population. Identifying exposures can be accomplished through analysis of serum during an outbreak to identify those with specific antibodies to the pathogen. The knowledge of the level of exposures could greatly impact the response to current and future pandemics.
This study is a prospective, longitudinal, observational, single-center, exploratory, natural history study to collect samples and data from individuals to identify the presence and rate of development of anti- SARS-CoV-2 antibodies in North Carolina.
Primary Objectives: To characterize the proportion of people with detectable antibodies to SARS-CoV-2 from a sampling of adults in North Carolina.
Objectives:
To identify the incidence of newly detectable antibodies to SARS-CoV-2 in the recruited cohort of adults in North Carolina over 12 months after enrollment
To identify the rate of asymptomatic carriers of SARS-CoV-2 (PCR positive) among participants with detectable antibodies to SARS-CoV-2
To associate presence or absence of detectable antibodies to SARS-CoV-2 with respiratory symptoms and future diagnosis with COVID-19
To determine the natural history of antibody titers among the participants who are found to have detectable antibodies
To associate demographic and medical factors with incidence of newly detectable antibodies to SARS-CoV-2
Eligibility Criteria
Adults 18 years or older
Sexes Eligible for Study: All
Able to read and speak English
Able to provide informed Consent
Able to communicate via email
Able to travel to study visits at the NIEHS CRU for required study visits
Stated willingness to comply with all study procedures and availability for the duration of the study
Seminar Recording
Principal Investigator
Stavros Garantziotis, M.D.
Tenure Track Investigator; Immunity, Inflammation, and Disease Laboratory
Tel 984-287-4412
Fax 919-541-9854
[email protected]
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Last Reviewed: December 30, 2025
Skip Navigation
Serological Surveillance for COVID-19 in Central North Carolina
Close the left navigation
Add
Study Background
This study is no longer accepting participants.
To find studies that are currently recruiting, please visit the
Join an
NIEHS Study
website
For More Information
ClinicalTrials.gov
NIH Clinical Studies
It has been demonstrated that respiratory virus outbreaks and pandemics, such as influenza, SARS, MERS, and now the newly emerged SARS-CoV-2 virus, have a major impact on morbidity and mortality worldwide, as well as having devastating global economic and societal impact. During these outbreaks it is critical to gain a rapid understanding of the exposures and immunity in the general population. Identifying exposures can be accomplished through analysis of serum during an outbreak to identify those with specific antibodies to the pathogen. The knowledge of the level of exposures could greatly impact the response to current and future pandemics.
This study is a prospective, longitudinal, observational, single-center, exploratory, natural history study to collect samples and data from individuals to identify the presence and rate of development of anti- SARS-CoV-2 antibodies in North Carolina.
Primary Objectives: To characterize the proportion of people with detectable antibodies to SARS-CoV-2 from a sampling of adults in North Carolina.
Objectives:
To identify the incidence of newly detectable antibodies to SARS-CoV-2 in the recruited cohort of adults in North Carolina over 12 months after enrollment
To identify the rate of asymptomatic carriers of SARS-CoV-2 (PCR positive) among participants with detectable antibodies to SARS-CoV-2
To associate presence or absence of detectable antibodies to SARS-CoV-2 with respiratory symptoms and future diagnosis with COVID-19
To determine the natural history of antibody titers among the participants who are found to have detectable antibodies
To associate demographic and medical factors with incidence of newly detectable antibodies to SARS-CoV-2
Eligibility Criteria
Adults 18 years or older
Sexes Eligible for Study: All
Able to read and speak English
Able to provide informed Consent
Able to communicate via email
Able to travel to study visits at the NIEHS CRU for required study visits
Stated willingness to comply with all study procedures and availability for the duration of the study
Seminar Recording
Principal Investigator
Stavros Garantziotis, M.D.
Tenure Track Investigator; Immunity, Inflammation, and Disease Laboratory
Tel 984-287-4412
Fax 919-541-9854
[email protected]
Back
to Top
Last Reviewed: December 30, 2025