E-Cigs and Smoking Study | National Institute of Environmental Health Sciences Skip Navigation E-Cigs and Smoking Study Close the left navigation Add Study Background This study is no longer accepting participants. To find studies that are currently recruiting, please visit the Join an NIEHS Study website For More Information ClinicalTrials.gov NIH Clinical Studies According to the Centers for Disease Control and Prevention, cigarette smoking causes more than 480,000 deaths each year in the United States, which translates to causing nearly one of every five deaths. Although the health impacts of smoking, such as cardiovascular and respiratory disease, cancer, and reduced fertility are well-documented, the goal of the E-Cigs and Smoking Study is to develop new biomarkers of tobacco smoke exposure or e-cigarette use. The biomarkers will be based on analysis of DNA methylation, which is the addition of methyl groups to DNA and is one of several epigenetic processes that occur in cells. Eligibility Criteria Healthy men and women aged 18-55 Current cigarette smokers or users of nicotine-containing e-cigarettes (can be using both) Principal Investigator Douglas A. Bell, Ph.D. (Retired) Special Volunteer Tel 984-287-3862 [email protected] Back to Top Last Reviewed: December 30, 2025