Hepatocyte Hypertrophy | National Institute of Environmental Health Sciences Skip Navigation Hepatocyte Hypertrophy Close the left navigation Add The Digitized Atlas of Mouse Liver Lesions Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS. Visit the NTP Website Centrilobular hepatocellular hypertrophy in a CD-1 mouse. Centrilobular hepatocytomegaly (hypertrophy) in a mouse given phenobarbital for 8 months. Note the prominent eosinophilic cytoplasm reflective of smooth endoplasmic reticulum proliferation. Back to Top Last Reviewed: February 04, 2026