Collaborative Studies | National Institute of Environmental Health Sciences Skip Navigation Collaborative Studies PEGS: Personalized Environment and Genes Study Close the left navigation Add About PEGS Data Snapshots Explore PEGS with i2b2 Frequently Asked Questions Results Explorer Study Data Study Design Study Participants Scientific Collaborations Collaboration Guidelines Collaborative Studies Policies and Process Submit a Proposal Leadership Team & Advisory Groups News & Updates Publications Researchers may collaborate with PEGS principal investigators (PIs) to conduct collaborative research studies. Investigators who wish to collaborate with PEGS should follow the Policies and Process Researchers can obtain data and samples from collaborative or add-on studies on a case-by-case basis. Study PIs and the PEGS Executive Leadership Committee (ELC) members can provide specifics on the types of data that have been collected, data available for new investigations and requests for additional data collection. Collaborative Studies Conducted Using the PEGS/EPR Data Project Investigator APOL1 Modulation of the Innate Immune Response in Human Disease Michael Fessler, M.D. A Prospective Natural History Study of Smoking, Immune Cell Profiles, Epigenetics, and COVID-19 Stavros Grantziotis, M.D. Black Cohosh Study Kristine Witt, M.S. Calorie Restriction, Environement and Fitness: Reproductive Effects Evalutation Study (CaREFRE) Study Janet Hall, M.D., M.S. CHDH (Choline Dehydrogenase) Male Fertility Study Tracy Clement, Ph.D. COPE Collaboration COVID-19 Andrew Chan, M.D., M.P.H. CXCL10/CXCR3 Regulation of Ozone-Induced Epithelial Permeability (Genetics in Ozone Lung Response) Robert Tighe, M.D. Demystifying a Girl's First Period Natalie Shaw, M.D. Drug Metabolism SNPs in the Lumbee Indian Population (DMETPlus) Howard McLeod, Pharm.D. Duke Medical Record Collaborations Svati Shah, M.D., M.H.S. E-cigs and Smoking Study Douglas Bell, Ph.D. Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage Daniel Menendez Rendon, Ph.D. Environmental Risk Factors for the Anti-synthetase Syndrome (Myorisk) Frederick Miller, M.D., Ph.D. EPR TNF-α SNP Genotyped Participants for Recruitment and Analyses of Race- and Gender-specific Associations of TNF-α SNP rs1800629 With Asthma Activity Shepherd Schurman, M.D. Ethical Approaches to Genotype Driven Reseach Recruitment Patricia Chulada, Ph.D. Genetic Basis for Susceptibility to Influenza Virus Illona Jaspers, Ph.D. Genetic Variants and Environmental Factors of Fatigue Leorey Saligan, Ph.D. Genotype-phenotype Environmental Relational Study Javed Mostafa, Ph.D. GIS Analysis of the NIEHS EPR Marie Lynn Miranda, Ph.D. Housing Characteristics and Sleep Health: Findings From the Environmental Polymorphisms Registry Chandra Jackson, Ph.D., M.S. Identifying the Role of Rubicon in Autoimmune Diseases (Rubicon) Jennifer Martinez, Ph.D. In vitro Modeling of Pulmonary Fibrosis Gene Variants (IPF) Stavros Grantziotis, M.D. Integrated Clinical and Environmental Exposures Service (ICEES)+ COVID Karamarie Fecho, Ph.D. Interaction Between LEP G2548A / LEPR Q223R Polymorphisms and Dietary Behaviors Montserrat Ayala-Ramirez, M.D., M.P.H. Investigation of Common Risk Factors for Immune Mediated Diseases Frederick Miller, M.D., Ph.D. Lung Inflammation Darryl Zeldin, M.D. Molecular Markers of Human Sperm Function Carmen Williams, M.D., Ph.D. Monarch Initiative Anne Thessen, M.D. Natural History of Asthma with Longitudinal Environmental Sampling (NHALES) Stavros Grantzioti, M.D. P2ry14 Polymorphisms and Asthma Donald Cook, Ph.D. Pilot: Detection of Somatic Genome Changes in Different Types of Cells and in Cell Free DNA Dmitry Gordenin, P.D. PPIP5K (diphosphoinositol pentakisphosphate kinase 2) Study Stephen Shears, P.D. Psoriasis Study Stavros Grantzioti, M.D. Right Not To Know (RNTK) Incidental Genetic Findings Survey Benjamin Berkman, J.D., M.P.H. Role of MDC1 in Repair of DNA Damage James Mason, P.D. Role of TGF-β in Asthmatic Epithelial Cell Susceptibility to RSV Infection (The Bronch Study) Stavros Grantzioti, M.D. Sample Registry: Microbiome Project Stavros Grantzioti, M.D. Smith-Lemli-Opitz Syndrome (SLOS) Study Pediatric Controls Michael Fessler, Ph.D. Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin Michael Fessler, Ph.D. The Detection of Mitochondrial DNA Deletions Using Next Generation Sequencing and a Novel Analysis Approach to Identify and Quantify Mitochondrial DNA Heteroplasmy William Copeland, Ph.D. The p53 Tumor Suppressor Enhances the Human Innate Immune Response to RSV Via a TLR8 SNP Daniel Menendez Rendon, Ph.D. The Role of Functionally Relevant Cyclooxygenase-2 (COX-2) Gene Single Nucleotide Polymorphisms -765G>C and 8473T>C in Lymphocyte Differentiation Darryl Zeldin, M.D. The Role of Glucocorticoid Receptor SNPs in Receptor Function and Metabolic Disease Stavros Grantziotis, M.D. The Role of the Functionally Relevant Single Nucleotide Polymorphisms CYP2J2-50G>T (CYP2J2*7) and EPHX2 9846A>G (EPHX2 K55R) in Human Endothelial Function (FMD) Darryl Zeldin, M.D. Toll-like Receptor 4 Pathway Polymorphisms Interact With Pollution to Influence Asthma Diagnosis and Severity (TLR4) Stavros Grantziotis, M.D. UNC Cystic Fibrosis Study 2007 Michael Knowles, M.D. UNC Joint Studies Bradford Powell, M.D., Ph.D. UNC Patient Record Linking David Borland, Ph.D., M.S. Understanding Participation in Genetic Research: The Experience of the Environmental Polymorphisms Registry Arlene Davis, J.D. Whole Genome Sequencing / Whole Exome Sequencing (WGS/WES) Pilot Study Trevor Archer, Ph.D. Back to Top Last Reviewed: February 04, 2026