Pluvicto® Extends Life of NC Man with Metastatic Prostate Cancer | Duke Health
Source: http://www.dukemedicine.org/blog/pluvicto-metastatic-prostate-cancer
Archived: 2026-04-23 17:25
Pluvicto® Extends Life of NC Man with Metastatic Prostate Cancer | Duke Health
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Ned Steele stands in the front yard of his Greensboro, NC home. Steele is being treated at Duke for metastatic prostate cancer.
Ned Steele has tried many treatments in the 18 years he’s been living with
prostate cancer
, but none has worked better than PLUVICTO®. Thanks to the efforts of Duke Health medical oncologist
Daniel George, MD
, and the team at
Duke Cancer Institute
, Steele was an early user of
PLUVICTO
for prostate cancer, receiving treatment through a clinical trial before it was FDA-approved in 2022. “PLUVICTO is a miracle drug,” said Steele.
Becoming a Duke Patient
Steele’s prostate cancer was already advanced when he was diagnosed in 2008. He sought treatment near his home in Greensboro and found early success with oral medication and brachytherapy, which places radioactive seeds inside the prostate.
His prostate cancer was under control for several years, until Steele’s prostate-specific antigen (PSA) levels -- a marker of prostate cancer -- started rising again. His doctor recommended cryotherapy, using extreme cold to freeze the cancer, but unfortunately, Steele had a rare reaction and his prostate exploded. He was rushed to Duke, where Duke Health urologist
Andrew C. Peterson, MD
, performed an 11-hour reconstructive surgery to improve Steele’s quality of life.
After surgery, Steele began working with Dr. George, who used a variety of treatments to manage his metastatic prostate cancer. Then Dr. George suggested PLUVICTO. “He told me there’s a new drug coming out that’s had incredible results and they were going to put me on the waiting list,” said Steele, now 76. A few months later, he was approved for treatment.
Hear Ned Steele's experience with PLUVICTO for treatment of his metastatic prostate cancer.
Incredible Results with Minimal Side Effects
Steele received the standard six doses of PLUVICTO -- an infusion given once every six weeks. “It would take about 45 minutes, if that,” said Steele. On PLUVICTO, Steele’s PSA levels plummeted and, other than some fatigue, he experienced no side effects. That’s because PLUVICTO is highly targeted, only seeking out tissue with prostate-specific membrane antigen (PSMA) -- a protein found on the surface of most prostate cancer cells. It attaches to PSMA and enters prostate cancer cells to deliver a high dose of radiation, which kills cancerous cells and bypasses healthy cells, unlike chemotherapy. This means fewer side effects like nausea, vomiting, and hair loss. “Ned’s story is a testament to how patients who persevere can often live long enough to benefit from treatments that didn’t even exist when their journey started,” said Dr. George.
Trying Again
Steele saw great results on PLUVICTO, but when he finished the six doses, his PSA levels started rising again. “I said, ‘Okay, Dr. George, what’s your next miracle?’” asked Steele. “I don't know how he did it, but he got me approved for PLUVICTO again.”
Today Steele has completed four additional rounds of PLUVICTO with two more to go. After experiencing first-hand the benefits of prostate cancer research, he is hopeful that researchers will continue to make new treatments like PLUVICTO so he and others like him can enjoy more years of life with metastatic prostate cancer. “We’re fighting the good fight,” said Steele.
Learn More About
PLUVICTO
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Daniel J. George, MD
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As a returning patient for this doctor, please schedule an appointment using your My Duke Health (MyChart) account.
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Don't have a My Duke Health (MyChart) account?
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If you have trouble logging in, have questions about how to use My Duke Health (MyChart), need more information about
your account, or need to contact customer service, please
view our FAQs
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Home
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Cancer Care Articles
Ready for an appointment?
New Appointments Within 48 Hours
866-832-3685
Ned Steele stands in the front yard of his Greensboro, NC home. Steele is being treated at Duke for metastatic prostate cancer.
Ned Steele has tried many treatments in the 18 years he’s been living with
prostate cancer
, but none has worked better than PLUVICTO®. Thanks to the efforts of Duke Health medical oncologist
Daniel George, MD
, and the team at
Duke Cancer Institute
, Steele was an early user of
PLUVICTO
for prostate cancer, receiving treatment through a clinical trial before it was FDA-approved in 2022. “PLUVICTO is a miracle drug,” said Steele.
Becoming a Duke Patient
Steele’s prostate cancer was already advanced when he was diagnosed in 2008. He sought treatment near his home in Greensboro and found early success with oral medication and brachytherapy, which places radioactive seeds inside the prostate.
His prostate cancer was under control for several years, until Steele’s prostate-specific antigen (PSA) levels -- a marker of prostate cancer -- started rising again. His doctor recommended cryotherapy, using extreme cold to freeze the cancer, but unfortunately, Steele had a rare reaction and his prostate exploded. He was rushed to Duke, where Duke Health urologist
Andrew C. Peterson, MD
, performed an 11-hour reconstructive surgery to improve Steele’s quality of life.
After surgery, Steele began working with Dr. George, who used a variety of treatments to manage his metastatic prostate cancer. Then Dr. George suggested PLUVICTO. “He told me there’s a new drug coming out that’s had incredible results and they were going to put me on the waiting list,” said Steele, now 76. A few months later, he was approved for treatment.
Hear Ned Steele's experience with PLUVICTO for treatment of his metastatic prostate cancer.
Incredible Results with Minimal Side Effects
Steele received the standard six doses of PLUVICTO -- an infusion given once every six weeks. “It would take about 45 minutes, if that,” said Steele. On PLUVICTO, Steele’s PSA levels plummeted and, other than some fatigue, he experienced no side effects. That’s because PLUVICTO is highly targeted, only seeking out tissue with prostate-specific membrane antigen (PSMA) -- a protein found on the surface of most prostate cancer cells. It attaches to PSMA and enters prostate cancer cells to deliver a high dose of radiation, which kills cancerous cells and bypasses healthy cells, unlike chemotherapy. This means fewer side effects like nausea, vomiting, and hair loss. “Ned’s story is a testament to how patients who persevere can often live long enough to benefit from treatments that didn’t even exist when their journey started,” said Dr. George.
Trying Again
Steele saw great results on PLUVICTO, but when he finished the six doses, his PSA levels started rising again. “I said, ‘Okay, Dr. George, what’s your next miracle?’” asked Steele. “I don't know how he did it, but he got me approved for PLUVICTO again.”
Today Steele has completed four additional rounds of PLUVICTO with two more to go. After experiencing first-hand the benefits of prostate cancer research, he is hopeful that researchers will continue to make new treatments like PLUVICTO so he and others like him can enjoy more years of life with metastatic prostate cancer. “We’re fighting the good fight,” said Steele.
Learn More About
PLUVICTO
SHARE:
Featured Doctors
Featured Doctors Images
Daniel J. George, MD
Medical Oncologist
Featured Doctors Images
Andrew C. Peterson, MD
Urologist
Schedule Online
New to This Doctor
I've Seen This Doctor Before
Related Doctors
You May Also Be Interested In...
Can I Get an Erection After a Prostatectomy?
Erectile dysfunction and urinary incontinence are common concerns after a radical prostatectomy because surgery can affect the nerves needed to achieve an erection and control your bladder. Fortunately, Duke Health surgeons are expertly equipped in techniques that spare those nerves, and offer a penile rehabilitation program to help you recover faster. Here, urologic oncologist Tara Morgan, MD, explains what you need to know if your doctor recommends a prostatectomy.
Read Article
Support Group Helps Men Cope with Prostate Cancer
Read Article
PSMA PET/CT Scan Improves Prostate Cancer Detection and...
Read Article
What You Should Know About Prostate Cancer
Read Article
Featured Doctors
Featured Doctors Images
Daniel J. George, MD
Medical Oncologist
Featured Doctors Images
Andrew C. Peterson, MD
Urologist
Schedule Online
New to This Doctor
I've Seen This Doctor Before
Related Doctors
Back to Top
Support Duke Health research or honor a loved one with a tribute gift.
Giving to Duke Health