Selected Publications | National Institute of Environmental Health Sciences

Selected Publications | National Institute of Environmental Health Sciences
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DNA Repair & Nucleic Acid Enzymology Group
Wilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-1536, 1972.  [
Abstract
Wilson, S.H. and Kuff, E.L. A novel DNA polymerase activity found in association with intracisternal A-type particles. Proc. Natl. Acad. Sci. USA, 69:1531-1536, 1972.
Matsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974. [
Abstract
Matsukage, A., Bohn, E.W., and Wilson, S.H. Multiple forms of DNA polymerase in mouse myeloma. Proc. Natl. Acad. Sci. USA, 71:578-582, 1974.
Tanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979. [
Abstract
Tanabe, K., Bohn, E.W., and Wilson, S.H. Steady-state kinetics of mouse DNA polymerase β. Biochemistry, 18:3401-3407, 1979.
Zmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986. [
Abstract
Zmudzka, B.Z., SenGupta, D., Matsukage, A., Cobianchi, F., Kumar, P., and Wilson, S.H. Structure of rat DNA polymerase β revealed by partial amino acid sequencing and cDNA cloning. Proc. Natl. Acad. Sci. USA, 83:5106-5110, 1986.
Widen, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988.  [
Abstract
Widen, S., Kedar, P., and Wilson, S.H. Human β-polymerase gene: Structure of the 5' flanking region and active promoter. J. Biol. Chem., 263:16992-16998, 1988.
Beard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993.  [
Abstract
Beard, W.A. and Wilson, S.H. Kinetic analysis of template primer interactions with recombinant forms of HIV-1 reverse transcriptase. Biochemistry, 32:9745-9753, 1993.
Narayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994. [
Abstract
Narayan, S., Widen, S.G., Beard, W.A., and Wilson, S.H. RNA polymerse II transcription: Rate of promoter clearance is enhanced by a purified activating transcription factor/cAMP response element-binding protein. J. Biol. Chem., 269, 12755-12763, 1994.
Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994. [
Abstract
Sawaya, M.R., Pelletier, H., Kumar, A., Wilson, S.H., and Kraut, J. Crystal structure of rat DNA polymerase β: Evidence for a common polymerase mechanism. Science, 264:1930-1935, 1994.
Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994. [
Abstract
Pelletier, H., Sawaya, M.R., Kumar, A., Wilson, S.H., and Kraut, J. Structures of ternary complexes of rat DNA polymerase β, a DNA template-primer, and ddCTP. Science, 264:1891-1903, 1994.
Singhal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995. [
Abstract
Singhal, R.K., Prasad, R., and Wilson, S.H. DNA polymerase β conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract. J. Biol. Chem., 270:949-957, 1995.
Kunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996. [
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Kunkel, T.A. and Wilson, S.H. DNA Repair. Push and pull of base flipping. Nature, 384:25-26, 1996.
Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996. [
Abstract
Sobol, R.W., Horton, J.K., Kühn, R., Gu, H., Singhal, R.K., Prasad, R., Rajewsky, K., and Wilson, S.H. Requirement of mammalian DNA polymerase-β in base-excision repair. Nature, 379:183-186, 1996.
He, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996. [
Abstract
He, F., Narayan, S., and Wilson, S.H. Purification and characterization of a DNA polymerase β promoter initiator element-binding transcription factor from bovine testis. Biochemistry, 35:1775-1782, 1996.
Srivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996. [
Abstract
Srivastava, D.K., Evans, R.K., Kumar, A., Beard, W.A., and Wilson, S.H. dNTP binding site in rat DNA polymerase β revealed by controlled proteolysis and azido photoprobe cross-linking. Biochemistry, 35:3728-3734, 1996.
Beard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996. [
Abstract
Beard, W.A., Osheroff, W.P., Prasad, R., Jaju, M., Sawaya, M.R., Wood, T.G., Kraut, J., Kunkel, T.A., and Wilson, S.H. Enzyme-DNA interactions required for efficient nucleotide incorporation and discrimination in human DNA polymerase β. J. Biol. Chem., 271:12141-12144, 1996.
Beard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996. [
Abstract
Beard, W.A., Minnick, D., Wade, C., Prasad, R., Won, R.L., Kumar, A., Kunkel, T.A., and Wilson, S.H. Role of the "Helix Clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis. J. Biol. Chem., 271: 12213-12220, 1996.
Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996. [
Abstract
Liu, D., Prasad, R., Wilson, S.H., DeRose, E.F., and Mullen, G.P. Three-dimensional solution structure of the N-terminal domain of DNA polymerase β and mapping of the ssDNA interaction interface. Biochemistry, 35:6188-6200, 1996.
Chyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996.  [
Abstract
Chyan, Y.-J., Strauss, P.R., Wood, T.G., and Wilson, S.H. Identification of novel mRNA isoforms for human DNA polymerase β. DNA and Cell Biology, 15:653-659, 1996.
Oda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996. [
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Oda, N., Saxena, J.K., Jenkins, T.M., Prasad, R., Wilson, S.H., and Ackerman, E.J. DNA polymerases β and β are required for DNA repair in an efficient nuclear extract from Xenopus oocytes. J. Biol. Chem., 271:13816-13820, 1996.
Prasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996. [
Abstract
Prasad, R., Singhal, R.K., Srivastava, D.K., Tomkinson, A.E., and Wilson, S.H. Specific interaction of DNA polymerase β and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem., 271:16000-16007, 1996.
Piersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996. [
Abstract
Piersen, C.E., Prasad, R., Wilson, S.H., and Lloyd, R.S. Evidence for an imino intermediate in the DNA polymerase β deoxyribose phosphate excision reaction. J. Biol. Chem., 271:17811-17815, 1996.
Narayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996. [
Abstract
Narayan, S., He, F., and Wilson, S.H. Activation of the human DNA polymerase β promoter by a DNA-alkylating agent through induced phosphorylation of CREB-1. J. Biol. Chem., 271:18508-18513, 1996.
Lavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996. [
Abstract
Lavrik, O.I., Prasad, R., Beard, W.A., Safronov, I.V., Dobrikov, M.I., Srivastava, D.K., Shishkin, G.V., Wood, T.G., and Wilson, S.H. dNTP binding to HIV-1 reverse transcriptase and mammalian DNA polymerase β as revealed by affinity labeling with a photoreactive dNTP analog. J. Biol. Chem., 271:21891-21897, 1996.
Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996. [
Abstract
Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. Crystal structures of human DNA polymerase β complexed with DNA: Implications for catalytic mechanism, processivity, and fidelity. Biochemistry, 35:12742-12761, 1996.
Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996. [
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Pelletier, H., Sawaya, M.R., Wolfle, W., Wilson, S.H., and Kraut, J. A structural basis for metal ion mutagenicity and nucleotide selectivity in human DNA polymerase β. Biochemistry, 35:12762-12777, 1996.
Reha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996. [
Abstract
Reha-Krantz, L.J., Nonay, R.L., Day III, R.S., and Wilson, S.H. Replication of O6-Methylguanine-containing DNA by repair and replicative DNA polymerases. J. Biol. Chem., 271:20088-20095, 1996.
Mullen, G.P. and Wilson, S.H. Repair activity in DNA polymerases: a structurally conserved helix-hairpin-helix motif in base excision repair enzymes and in DNA polymerase β. IN: Hickson, I.D. (ed), Base Excision Repair of DNA Damage. Landes Bioscience, 1997, pp. 121-135.
Strauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997. [
Abstract
Strauss, P.R., Beard, W.A., Patterson, T.A., and Wilson, S.H. Substrate binding by human apurinic/apyrimidinic endonuclease indicates a Briggs-Haldane Mechanism. J. Biol. Chem., 272:1302-1307, 1997.
Efrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997. [
Abstract
Efrati, E., Tocco, G., Eritja, R., Wilson, S.H., and Goodman, M.F. Abasic translesion synthesis by DNA polymerase β violates the "A-Rule": Novel types of nucleotide incorporation by human DNA polymerase β at an abasic lesion in different sequence contexts. J. Biol. Chem., 272:2559-2569, 1997.
Forgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997. [
Abstract
Forgacs, E., Latham, G., Beard, W.A., Prasad, R., Bebenek, K., Kunkel, T.A., Wilson, S.H., and Lloyd, R.S. Probing structure/function relationships of HIV-1 reverse transcriptase with styrene oxide N2-Guanine adducts. J. Biol. Chem., 272:8525-8530, 1997.
Kim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997. [
Abstract
Kim, S., Merrill, B.M., Rajpurohit, R., Kumar, A., Stone, K.L., Papov, V.V., Schneidersm J.M., Szer, W., Wilson, S.H., Paik, W.K., and Williams, K.R. Identification of NG-Methylarginine residues in human heterogeneous RNP protein A1: Phe/Gly-Gly-Gly-Arg-Gly-Gly-Gly/Phe is a preferred recognition motif. Biochemistry, 36:5185-5192, 1997.
Mullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997. [
Abstract
Mullen, G.P. and Wilson, S.H. DNA polymerase β in abasic site repair: a structurally conserved helix-hairpin-helix motif in lesion detection by base excision repair enzymes. Biochemistry, 36:4713-4717, 1997.
Bebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997. [
Abstract
Bebenek, K., Beard, W.A., Darden, T.A., Li, L., Prasad, R., Luxon, B.A., Gorenstein, D.G., Wilson, S.H., and Kunkel, T.A. A minor groove binding track in reverse transcriptase. Nat. Struct. Biol., 4:194-197, 1997.
Butler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997. [
Abstract
Butler, A.P., Johnson, D.G., Kumar, A.P., Narayan, S., Wilson, S.H., and MacLeod, M.C. Disruption of transcription in vitro and gene expression in vivo by DNA adducts derived from a benzo[a]pyrene diol epoxide located in heterologous sequences. Carcinogenesis, 18:239-244, 1997.
Mullen, G.P., Antuch, W., Maciejewski, M.W., Prasad, R., and Wilson, S.H. Insights into the mechanism of the β-elimination catalyzed by the N-terminal domain of DNA polymerase β. Tetrahedron, 53:12057-12066, 1997.
Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997. [
Abstract
Sawaya, M.R., Prasad, R., Wilson, S.H., Kraut, J., and Pelletier, H. Crystal structures of human DNA polymerase β complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry, 36:11205-11215, 1997.
Yang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997. [
Abstract
Yang, X-P., He, F., Rawson, T.Y., and Wilson, S.H. Human DNA polymerase β promoter: Phorbol ester activation is mediated through the cAMP response element and cAMP-response-element-binding protein. J. Biomed. Sci., 4:279-288, 1997.
Wilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155. [
Abstract
Wilson, S.H., Sobol, R.W., Beard, W.A., Horton, J.K., Prasad, R., and Vande Berg, B.J. DNA polymerase-β and mammalian base excision repair. IN: Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory Press, 2000, Vol. 65, pp. 143-155.
Beard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002. [
Abstract
Beard, W.A., Shock, D.D., Yang, X.-P., DeLauder, S.F., and Wilson, S.H. Loss of DNA polymerase β stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity. J. Biol. Chem., 277:8235-8242, 2002.
Beard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002. [
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Beard, W.A., Shock, D.D., Vande Berg, B.J., and Wilson, S.H. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J. Biol. Chem., 277:47393-47398, 2002.
Beard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003. [
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Beard, W.A., and Wilson, S.H. Structural insights into the origins of DNA polymerase fidelity. Structure (Camb.), 11:489-496, 2003.
Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005. [
Abstract
Horton, J.K., Stefanick, D.F., Naron, J.M., Kedar, P.S., and Wilson, S.H. Poly(ADP-ribose) polymerase activity prevents signaling pathways for cell cycle arrest following DNA methylating agent exposure. J. Biol. Chem., 280:15773-15785, 2005.
Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005.  [
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Batra, V.K., Beard, W.A., Shock, D.D., Pedersen, L.C., and Wilson, S.H. Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate. Structure (Camb.), 13:1225-1233, 2005.
Prasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005. [
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Prasad, R., Batra, V.K., Yang, X.-P., Krahn, J.M., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Structural insight into the DNA polymerase β deoxyribose phosphate lyase mechanism. DNA Repair (Amst.), 4:1347-1357, 2005.
Kirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005. [
Abstract
Kirby, T.W., DeRose, E.F., Beard, W.A., Wilson, S.H., and London, R.E. A thymine isostere in the templating position disrupts assembly of the closed DNA polymerase β ternary complex. Biochemistry, 44:15230-15237, 2005.
Beard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006. [
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Beard, W.A. and Wilson, S.H. Structure and mechanism of DNA polymerase β. Chemical Reviews, "DNA Damage and Repair," 106:361-382, 2006.
Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006. [
Abstract
Batra, V.K., Beard, W.A., Shock, D.D., Krahn, J.M., Pedersen, L.C., and Wilson, S.H. Magnesium-induced assembly of a complete DNA polymerase catalytic complex. Structure (Camb.), 14:757-766, 2006.
Yoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006. [
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Yoshimura, M., Kohzaki, M., Nakamura, J., Asagoshi, K., Sonoda, E., Hou, E., Prasad, R., Wilson, S.H., Tano, K., Yasui, A., Lan, L., Seki, M., Wood, R.D., Arakawa, H. Buerstedde, J.-M., Hochegger, H., Okada, T., Hiraoka, M., and Takeda, S. Vertebrate PolQ and Polβ cooperate in base excision repair of oxidative DNA damage. Mol. Cell, 24:115-125, 2006.
Lin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006. [
Abstract
Lin, P., Pedersen, L.C., Batra, V.K., Beard, W.A., Wilson, S.H., and Pedersen, L.G. Energy analysis of chemistry for correct nucleotide insertion by DNA polymerase β. Proc. Natl. Acad. Sci. USA, 103:13294-13299, 2006.
Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006. [
Abstract
Batra, V.K., Shock, D.D., Prasad, R., Beard, W.A., Hou, E.W., Pedersen, L.C., Sayer, J.M., Yagi, H., Kumar, S., Jerina, D.M., and Wilson, S.H. Structure of DNA polymerase β with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. Proc. Natl. Acad. Sci. USA, 103:17231-17236, 2006.
Radhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006. [
Abstract
Radhakrishnan, R., Arora, K., Wang, Y., Beard, W.A., Wilson, S.H., and Schlick, T. Regulation of DNA repair fidelity by molecular checkpoints: "Gates" in DNA polymerase β’s substrate selection. Biochemistry, 45:15142-15156, 2006.
Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T. NEIL2-Initiated, APE-independent repair of oxidated bases in DNA: Evidence for a repair complex in human cell. DNA repair 5(12):1439-1448, 2006. [
Abstract
Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T. NEIL2-Initiated, APE-independent repair of oxidated bases in DNA: Evidence for a repair complex in human cell. DNA repair 5(12):1439-1448, 2006.
Horton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.), 6(6):742-50, 2007. [
Abstract
Horton, J.K., Stefanick, D.F., Kedar, P.S., and Wilson, S.H. ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. DNA Repair (Amst.), 6(6):742-50, 2007.
Wang Y., Reddy S., Beard W.A., Wilson S.H., Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal, 9: 3063-3070, 2007. [
Abstract
Wang Y., Reddy S., Beard W.A., Wilson S.H., Schlick T. Differing conformational pathways before and after chemistry for insertion of dATP vs. dCTP opposite 8-oxoG in DNA polymerase beta. Biophysical journal, 9: 3063-3070, 2007.
Das S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry, 282(39):28474-28484, 2007. [
Abstract
Das S., Chattopadhyay R., Bhakat K.K., Boldogh I., Kohno K., Prasad R., Wilson S.H., Hazra T.K. Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress. The Journal of biological chemistry, 282(39):28474-28484, 2007.
Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair, 6(12):1709-1725, 2007. [
Abstract
Moon, A.F., Garcia-Diaz, M., Batra, V.K., Beard, W.A., Bebenek, K., Kunkel, T.A., Wilson, S.H., Pedersen, L.C. The X family portrait: structural insights into biological functions of X family polymerases. DNA repair, 6(12):1709-1725, 2007.
Kovtun, I.V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S.H., McMurray, C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature, 447(7143):447-452, 2007. [
Abstract
Kovtun, I.V., Liu, Y., Bjoras, M., Klungland, A., Wilson, S.H., McMurray, C.T. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature, 447(7143):447-452, 2007.
Liu, Y., Prasad, R., Beard, W.A., Kedar, P.S., Hou, E.W., Shock, D.D., Wilson, S.H. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry, 282(18):13532-13541, 2007. [
Abstract
Liu, Y., Prasad, R., Beard, W.A., Kedar, P.S., Hou, E.W., Shock, D.D., Wilson, S.H. Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase β. The Journal of biological chemistry, 282(18):13532-13541, 2007.
Nakanishi, S., Prasad R., Wilson S.H., Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research, 35(13):4313-4321, 2007. [
Abstract
Nakanishi, S., Prasad R., Wilson S.H., Smerdon M. Different structural states in oligonucleosomes are required for early versus late steps of base excision repair. Nucleic Acids Research, 35(13):4313-4321, 2007.
Palma, N., Cinelli S., Sapora O., Wilson S.H., Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress. Chemical research in toxicology, 20(7):1031-1037, 2007. [
Abstract
Palma, N., Cinelli S., Sapora O., Wilson S.H., Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with production of oxidative stress. Chemical research in toxicology, 20(7):1031-1037, 2007.
Tano, K., Nakamura J., Asagoshi K., Arakawa H., Sonoda E., Braithwaite E.K., Prasad R., Buerstedde J.-M., Takeda S., Watanabe M., Wilson S.H. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair, 6(6):869-875, 2007. [
Abstract
Tano, K., Nakamura J., Asagoshi K., Arakawa H., Sonoda E., Braithwaite E.K., Prasad R., Buerstedde J.-M., Takeda S., Watanabe M., Wilson S.H. Interplay between DNA polymerases beta and lambda in repair of oxidation DNA damage in chicken DT40 cells. DNA repair, 6(6):869-875, 2007.
Oelschlaeger, P., Klahn M., Beard W.A., Wilson S.H., Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology, 366(2):687-701, 2007. [
Abstract
Oelschlaeger, P., Klahn M., Beard W.A., Wilson S.H., Warshel A. Magnesium-cationic dummy atom molecules enhance representation of DNA polymerase beta in molecular dynamics simulations: Improved accuracy in studies of structural features and mutational effects. Journal of molecular biology, 366(2):687-701, 2007.
Hou, E.W., Prasad R., Asagoshi K., Masaoka A., Wilson S.H. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research, 35(17):e112, 2007. [
Abstract
Hou, E.W., Prasad R., Asagoshi K., Masaoka A., Wilson S.H. Comparative assessment of plasmid and oligonucleotide DNA substrates in measurement of in vitro base excision repair activity. Nucleic acids research, 35(17):e112, 2007.
McKenna, C.E., Kashemirov B.A., Upton T.G., Batra V.K., Goodman M.F., Pedersen L.C., Beard W.A., Wilson S.H. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society, 129(50):15412-15413, 2007. [
Abstract
McKenna, C.E., Kashemirov B.A., Upton T.G., Batra V.K., Goodman M.F., Pedersen L.C., Beard W.A., Wilson S.H. (R)-beta,gamma-fluoromethylene-dGTP-DNA ternary complex with DNA polymerase beta. Journal of the American Chemical Society, 129(50):15412-15413, 2007.
Prasad, R., Liu Y., Deterding L.J., Poltoratsky V.P., Kedar P.S., Horton J.K., Kanno S.I., Asagoshi K., Hou E.W., Khodyreva S.N., Lavrik O.I., Tomer K.B., Yasui A., Wilson S.H. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell, 27(5):829-841, 2007. [
Abstract
Prasad, R., Liu Y., Deterding L.J., Poltoratsky V.P., Kedar P.S., Horton J.K., Kanno S.I., Asagoshi K., Hou E.W., Khodyreva S.N., Lavrik O.I., Tomer K.B., Yasui A., Wilson S.H. HMGB1 is a co-factor in mammalian base excision repair. Molecular cell, 27(5):829-841, 2007.
Wilson SH. DNA Damage Recognition, W. Siede, W. Kow, P. Doetsch (Eds.), Taylor & Francis Group. New York (2006) ISBN: 10-0-8247-5961-3; 13:978-0-8247-5961-2. DNA Repair 2007.
Horton, J.K., Watson M., Stefanick D.F., Shaughnessy D.T., Taylor J.A., Wilson S.H. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research, 18(1):48-63, 2008. [
Abstract
Horton, J.K., Watson M., Stefanick D.F., Shaughnessy D.T., Taylor J.A., Wilson S.H. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell research, 18(1):48-63, 2008.
Xiang, Y., Goodman M.F., Beard W.A., Wilson S.H., Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins, 70(1):231-247, 2008. [
Abstract
Xiang, Y., Goodman M.F., Beard W.A., Wilson S.H., Warshel A. Exploring the role of large conformational changes in the fidelity of DNA Polymerase beta. Proteins, 70(1):231-247, 2008.
Batra, V.K., Beard W.A., Shock D.D., Pedersen L.C., Wilson S.H. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell, 30(3):315-324, 2008. [
Abstract
Batra, V.K., Beard W.A., Shock D.D., Pedersen L.C., Wilson S.H. Structures of DNA polymerase beta with active site mismatches suggest a transient abasic site intermediate during misincorporation. Molecular cell, 30(3):315-324, 2008.
Kronenberg, G., Harms C., Sobol R.W., Cardozo-Pelaez F., Linhart H., Winter B., Balkaya M., Gertz K., Gay S.B., Cox D., Eckart S., Ahmadi M., Juckel G., Kempermann G., Hellweg R., Sorh R., Hortnagl H., Wilson S.H., Jaenisch R., Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience: the official journal of the Society for Neuroscience. 28(28):7219-7230, 2008. [
Abstract
Kronenberg, G., Harms C., Sobol R.W., Cardozo-Pelaez F., Linhart H., Winter B., Balkaya M., Gertz K., Gay S.B., Cox D., Eckart S., Ahmadi M., Juckel G., Kempermann G., Hellweg R., Sorh R., Hortnagl H., Wilson S.H., Jaenisch R., Endres M. Folate deficiency induces neurodegeneration and brain dysfunction in mice lacking uracil DNA glycosylase. The Journal of neuroscience: the official journal of the Society for Neuroscience. 28(28):7219-7230, 2008.
Kedar, P.S., Stefanick D.F., Horton J.K., Wilson S.H. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair, 7(11):1787-1798, 2008. [
Abstract
Kedar, P.S., Stefanick D.F., Horton J.K., Wilson S.H. Interaction between PARP-1 and ATR in mouse fibroblasts is blocked by PARP inhibition. DNA repair, 7(11):1787-1798, 2008.
Allen, D., Herbert D.C., McMahan C.A., Rotrekl V., Sobol R.W., Wilson S.H., Walter C.A. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction, 79(5):824-831, 2008. [
Abstract
Allen, D., Herbert D.C., McMahan C.A., Rotrekl V., Sobol R.W., Wilson S.H., Walter C.A. Mutagenesis is elevated in male germs cells obtained from DNA polymerase-beta heterozygous mice. Biology of reproduction, 79(5):824-831, 2008.
Poltoratsky, V.P., Horton, J.K., Prasad, R., Beard, W.A., Woodgate, R., Wilson, S.H. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair, 7(6):830-833, 2008. [
Abstract
Poltoratsky, V.P., Horton, J.K., Prasad, R., Beard, W.A., Woodgate, R., Wilson, S.H. Negligible impact of pol iota expression on the alkylation sensitivity of pol beta-deficient mouse fibroblast cells. DNA repair, 7(6):830-833, 2008.
Liang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W.A., Wilson, S.H., Chiarelli, N.P., Cho, B.P. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of medicinal chemistry, 51(20):6460-6470, 2008. [
Abstract
Liang, F., Jain, N., Hutchens, T., Shock, D.D., Beard, W.A., Wilson, S.H., Chiarelli, N.P., Cho, B.P. Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT. Journal of medicinal chemistry, 51(20):6460-6470, 2008.
Carrozza, M., Stefanick, D.F., Horton, J.K., Kedar, P.S., Wilson, S.H. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA Repair, 8(11):1264-1272, 2009. [
Abstract
Carrozza, M., Stefanick, D.F., Horton, J.K., Kedar, P.S., Wilson, S.H. PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM. DNA Repair, 8(11):1264-1272, 2009.
Liu, Y., Prasad R., Beard W.A., Hou E.W., Horton J.K., McMurray C.T., Wilson S.H. Coordination between Pol ² and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry, 284(41):28352-28366, 2009. [
Abstract
Liu, Y., Prasad R., Beard W.A., Hou E.W., Horton J.K., McMurray C.T., Wilson S.H. Coordination between Pol ² and FEN1 can modulate CAG repeat expansion. The Journal of biological chemistry, 284(41):28352-28366, 2009.
Dorjsuren, D., Wilson III D.M., Beard W.A., McDonald J.P., Austin C.P., Woodgate R., Wilson S.H., Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research, 37(19):e128, 2009. [
Abstract
Dorjsuren, D., Wilson III D.M., Beard W.A., McDonald J.P., Austin C.P., Woodgate R., Wilson S.H., Simeonov A. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic acids research, 37(19):e128, 2009.
Yoshizawa, K., Jelezcova E., Brown A.R., Foley J.F., Nyska A., Cui X., Hofseth L., Maronpot R., Wilson S.H., Sepulveda A.R., Sobol R.W. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one, 4(8):e6493, 2009. [
Abstract
Yoshizawa, K., Jelezcova E., Brown A.R., Foley J.F., Nyska A., Cui X., Hofseth L., Maronpot R., Wilson S.H., Sepulveda A.R., Sobol R.W. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta. PloS one, 4(8):e6493, 2009.
Simonelli, V., D'Errico M., Palli D., Prasad R., Wilson S.H., Dogliotti E. Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research, 670(1-2):79-87, 2009. [
Abstract
Simonelli, V., D'Errico M., Palli D., Prasad R., Wilson S.H., Dogliotti E. Characterization of DNA polymerase beta splicing variants in gastric cancer: the most frequent exon 2-deleted isoform is a non-coding RNA. Mutation research, 670(1-2):79-87, 2009.
Prasad, R., Longley, M.J., Sharief, F.S., Hou, E.W., Copeland, W.C., and Wilson S.H. Human DNA polymerase theta¸ possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research, 37(6):1868-1877, 2009. [
Abstract
Prasad, R., Longley, M.J., Sharief, F.S., Hou, E.W., Copeland, W.C., and Wilson S.H. Human DNA polymerase theta¸ possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro. Nucleic acids research, 37(6):1868-1877, 2009.
Masaoka, A., Horton, J.K., Beard, W.A., and Wilson, S.H. DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair, 8(11):1290-1299, 2009. [
Abstract
Masaoka, A., Horton, J.K., Beard, W.A., and Wilson, S.H. DNA polymerase beta and PARP activities in base excision repair in living cells. DNA repair, 8(11):1290-1299, 2009.
Beard, W.A., Shock, D.D., Batra, V.K., Pedersen, L.C., and Wilson, S.H. DNA Polymerase Beta Substrate Specificity: Side chain modulation of the 'A-rule'. The Journal of biological chemistry, 284(46):31680-31689, 2009. [
Abstract
Beard, W.A., Shock, D.D., Batra, V.K., Pedersen, L.C., and Wilson, S.H. DNA Polymerase Beta Substrate Specificity: Side chain modulation of the 'A-rule'. The Journal of biological chemistry, 284(46):31680-31689, 2009.
Upton, T.G., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Prakash, G.K., Kultyshev, R., Batra, V.K., Shock, D.D., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters, 11(9):1883-1886, 2009. [
Abstract
Upton, T.G., Kashemirov, B.A., McKenna, C.E., Goodman, M.F., Prakash, G.K., Kultyshev, R., Batra, V.K., Shock, D.D., Pedersen, L.C., Beard, W.A., and Wilson, S.H. Alpha,beta-difluoromethylene deoxynucleoside 5'-triphosphates: a convenient synthesis of useful probes for DNA polymerase beta structure and function. Organic Letters, 11(9):1883-1886, 2009.
Tano, K., Chastain II, P.D., Asagoshi, K., Adachi, N., Sonoda, E., Kikuchi, K., Koyama, H., Nagata, K., Kaufman, D.G., Takeda, S., Wilson, S.H., Watanabe, M., Swenberg, J.A., and Nakamura, J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Molecular cancer research, 8(2):204-215, 2010. [
Abstract
Tano, K., Chastain II, P.D., Asagoshi, K., Adachi, N., Sonoda, E., Kikuchi, K., Koyama, H., Nagata, K., Kaufman, D.G., Takeda, S., Wilson, S.H., Watanabe, M., Swenberg, J.A., and Nakamura, J. FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells. Molecular cancer research, 8(2):204-215, 2010.
Asagoshi, K., Liu, Y., Masaoka, A., Lan, L., Prasad, R., Horton, J.K., Brown, A.R., Wang, X.H., Sobol, R.W., Bdour, H.M., Taylor, J.S., Yasui, A., and Wilson, S.H. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair, 9(2):109-119, 2010. [
Abstract
Asagoshi, K., Liu, Y., Masaoka, A., Lan, L., Prasad, R., Horton, J.K., Brown, A.R., Wang, X.H., Sobol, R.W., Bdour, H.M., Taylor, J.S., Yasui, A., and Wilson, S.H. DNA polymerase beta-dependent long patch base excision repair in living cells. DNA repair, 9(2):109-119, 2010.
Lui, Y., Prasad, R., and Wilson, S.H. HMGB1: Roles in base excision repair and related function. Biochimica et biophysica acta, 1799(1-2):119-130, 2010. [
Abstract
Lui, Y., Prasad, R., and Wilson, S.H. HMGB1: Roles in base excision repair and related function. Biochimica et biophysica acta, 1799(1-2):119-130, 2010.
Heacock, M., Stefanick, D., Horton, J.K. and Wilson, S.H. Alkylation damage combined with PARP inhibition in cells results in S-phase dependent double-strand breaks. DNA repair, 9(8):929-936, 2010. [
Abstract
Heacock, M., Stefanick, D., Horton, J.K. and Wilson, S.H. Alkylation damage combined with PARP inhibition in cells results in S-phase dependent double-strand breaks. DNA repair, 9(8):929-936, 2010.
Batra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., and Wilson, S.H. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology, 17(7):889-890, 2010. [
Abstract
Batra, V.K., Beard, W.A., Hou, E.W., Pedersen, L.C., Prasad, R., and Wilson, S.H. Mutagenic conformation of 8-oxo-7,8-dihydro-2'-dGTP in the confines of a DNA polymerase active site. Nature structural & molecular biology, 17(7):889-890, 2010.
Poltoratsky, V., Heacock, M., Kissling, G.E., Prasad, R., Wilson, S.H. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology 48(1-3):164-170, 2010. [
Abstract
Poltoratsky, V., Heacock, M., Kissling, G.E., Prasad, R., Wilson, S.H. Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand break. Molecular immunology 48(1-3):164-170, 2010.
Khodyreva, S.N., Prasad, R., Ilina, E.S., Sukhanova, M.M., Kutuzov, Y., Liu, Y., Hou, E.W., Wilson, S.H., Lavrik, O.I. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America 107(51):22090-22095, 2010. [
Abstract
Khodyreva, S.N., Prasad, R., Ilina, E.S., Sukhanova, M.M., Kutuzov, Y., Liu, Y., Hou, E.W., Wilson, S.H., Lavrik, O.I. Apurinic/apyrimidinic (AP) site recognition by the 5'-dRP/AP lyase in poly(ADP-ribose) polymerase-1 (PARP-1). Proceedings of the National Academy of Sciences of the United States of America 107(51):22090-22095, 2010.
Braithwaite, E.K., Kedar, P.S., Stumpo, D.J., Bertocci, B., Freedman, J.H., Samson, L.D., Wilson, S.H. DNA Polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one 5(8):e12229-, 2010. [
Abstract
Braithwaite, E.K., Kedar, P.S., Stumpo, D.J., Bertocci, B., Freedman, J.H., Samson, L.D., Wilson, S.H. DNA Polymerases beta and lambda mediate overlapping and independent roles in base excision repair in mouse embryonic fibroblasts. PloS one 5(8):e12229-, 2010.
Cavanaugh, N.A., Beard, W.A., and Wilson, S.H. DNA Polymerase beta ribonucleotide discrimination: Insertion, misinsertion, extension, and coding. The Journal of biological chemistry, 285(32):24457-24465, 2010. [
Abstract
Cavanaugh, N.A., Beard, W.A., and Wilson, S.H. DNA Polymerase beta ribonucleotide discrimination: Insertion, misinsertion, extension, and coding. The Journal of biological chemistry, 285(32):24457-24465, 2010.
Prasad R, Shock DD, Beard WA, Wilson SH. Passing the baton: Substrate channeling in mammalian base excision repair pathways. The Journal of biological chemistry 285(52):40479-40488, 2010. [
Abstract
Prasad R, Shock DD, Beard WA, Wilson SH. Passing the baton: Substrate channeling in mammalian base excision repair pathways. The Journal of biological chemistry 285(52):40479-40488, 2010.
Beard, WA, Batra, VK, Wilson, SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research 703(1):18-23, 2010. [
Abstract
Beard, WA, Batra, VK, Wilson, SH. DNA polymerase structure-based insight on the mutagenic properties of 8-oxoguanine. Mutation research 703(1):18-23, 2010.
Surya-Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertel, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America 107(36):15693-15698, 2010. [
Abstract
Surya-Prakash, G.K., Zibinsky, M., Upton, T.G., Kashemirov, B.A., McKenna, C.E., Oertel, K., Goodman, M.F., Batra, V.K., Pedersen, L.C., Beard, W.A., Shock, D.D., Wilson, S.H., Olah, G.A. Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid. Proceedings of the National Academy of Sciences of the United States of America 107(36):15693-15698, 2010.
Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA , Prasad R, Hou EW, Liu Y, Asagoshi, K, Horton JK, Stefanick DF, Kedar PS , Carrozza, MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and molecular life sciences  67(21):3633-47, 2010. [
Abstract
Wilson SH, Beard WA, Shock DD, Batra VK, Cavanaugh NA , Prasad R, Hou EW, Liu Y, Asagoshi, K, Horton JK, Stefanick DF, Kedar PS , Carrozza, MJ, Masaoka A, Heacock ML. Base excision repair and design of small molecule inhibitors of human DNA polymerase β. Cellular and molecular life sciences  67(21):3633-47, 2010.
Horton, J.K., Stefanick, D.F., Zeng, J.Y., Carrozza, M.J., Wilson, S.H. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair 10(2):225-234, 2011. [
Abstract
Horton, J.K., Stefanick, D.F., Zeng, J.Y., Carrozza, M.J., Wilson, S.H. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA repair 10(2):225-234, 2011.
Cavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.C., Wilson, S.H. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry 286(36):31650-31660, 2011. [
Abstract
Cavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.C., Wilson, S.H. Molecular insights into DNA polymerase deterrents for ribonucleotide insertion. The Journal of biological chemistry 286(36):31650-31660, 2011.
Prasad, R., Beard, W.A., Batra, V.K., Liu, Y., Shock, D.D., Wilson, S.H. A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Mol. Biol. 45(4):586-600, 2011. [
Abstract
Prasad, R., Beard, W.A., Batra, V.K., Liu, Y., Shock, D.D., Wilson, S.H. A review of recent experiments on step-to-step "hand-off" of the DNA intermediates in mammalian base excision repair pathways. Mol. Biol. 45(4):586-600, 2011.
Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. 2011. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.
PLoS One
. 6(9):e23679. doi: 10.1371/journal.pone.0023679. [
Abstract
Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, Wilson SH, Waring MJ. 2011. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One. 6(9):e23679. doi: 10.1371/journal.pone.0023679.
Kedar, P.S., Stefanick, D.F., Horton, J.K. and Wilson, S.H. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research 10:360-368, 2012. [
Abstract
Kedar, P.S., Stefanick, D.F., Horton, J.K. and Wilson, S.H. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Molecular Cancer Research 10:360-368, 2012.
Liu, Y. and Wilson, S.H. Linkage between trinucleotide repeat expansion, oxidative stress and base excision repair. Trends in Biochemical Sciences 37:162-172, 2012.
Kirby, T., DeRose, E., Cavanaugh, N., Beard, W.A., Shock, D.D., Mueller, G., Wilson, S.H. and London, R. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research 40: 2974-2983, 2012.
Abstract
Kirby, T., DeRose, E., Cavanaugh, N., Beard, W.A., Shock, D.D., Mueller, G., Wilson, S.H. and London, R. Metal-induced DNA translocation leads to DNA polymerase conformational activation. Nucleic Acids Research 40: 2974-2983, 2012.
Batra, V.K., Shock, D.D., Beard,W.A., McKenna, Charles E. and Wilson, S.H. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences, USA 109:113-118, 2012. [
Abstract
Batra, V.K., Shock, D.D., Beard,W.A., McKenna, Charles E. and Wilson, S.H. Binary complex crystal structure of DNA polymerase β reveals multiple conformations of the templating 8-oxoguanine lesion. Proceedings of the National Academy of Sciences, USA 109:113-118, 2012.
Asagoshi, K., Lehmann, W., Braithwaite, E.K., Santana-Santos, L., Prasad, R., Freedman, J.K., Van Houten, B., and Wilson, S.H. Single nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research 40:670-681, 2012 [
Abstract
Asagoshi, K., Lehmann, W., Braithwaite, E.K., Santana-Santos, L., Prasad, R., Freedman, J.K., Van Houten, B., and Wilson, S.H. Single nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β. Nucleic Acids Research 40:670-681, 2012
Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F. and Wilson, S.H. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. ChemBioChem 13:528-530, 2012. [
Abstract
Chamberlain, B.T., Batra, V.K., Beard, W.A., Kadina, A.P., Shock, D.D., Kashemirov, B.A., McKenna, C.E., Goodman, M.F. and Wilson, S.H. Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β. ChemBioChem 13:528-530, 2012.
Nakano H, Free ME, Whitehead GS, Maruoka S, Wison RH, Nakano K, Cook DN. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal immunology 5(1):53-65, 2012. [
Abstract
Nakano H, Free ME, Whitehead GS, Maruoka S, Wison RH, Nakano K, Cook DN. Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal immunology 5(1):53-65, 2012.
Liu Y, Wilson SH. DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences,  37(4):162-72, 2012. [
Abstract
Liu Y, Wilson SH. DNA base excision repair: a mechanism of trinucleotide repeat expansion. Trends in biochemical sciences,  37(4):162-72, 2012.
Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLOS ONE 7(11):e49301, 2012. [
Abstract
Gassman NR, Stefanick DF, Kedar PS, Horton JK, Wilson SH. Hyperactivation of PARP triggers nonhomologous end-joining in repair-deficient mouse fibroblasts. PLOS ONE 7(11):e49301, 2012.
Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England: 1993) 20(11):1829-1837, 2012. [
Abstract
Freudenthal BD, Beard WA, Wilson SH. Structures of dNTP intermediate states during DNA polymerase active site assembly. Structure (London, England: 1993) 20(11):1829-1837, 2012.
Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β [beta],γ[gamma]-CHF- and β [beta],γ[gamma]-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society 134(21):8734-8737, 2012.  [
Abstract
Wu Y, Zakharova VM, Kashemirov BA, Goodman MF, Batra VK, Wilson SH, McKenna CE. β [beta],γ[gamma]-CHF- and β [beta],γ[gamma]-CHCl-dGTP diastereomers: synthesis, discrete 31P NMR signatures, and absolute configurations of new stereochemical probes for DNA polymerases. Journal of the American Chemical Society 134(21):8734-8737, 2012.
Masaoka A, Gassman NR, Kedar PS, Prasad R, Hou E, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry, 287(22):27648-27658, 2012. [
Abstract
Masaoka A, Gassman NR, Kedar PS, Prasad R, Hou E, Horton JK, Bustin M, Wilson SH. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. The Journal of biological chemistry, 287(22):27648-27658, 2012.
Sassa A, Beard W.A., Prasad R., Wilson S.H. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry 287(44):36702-36710, 2012. [
Abstract
Sassa A, Beard W.A., Prasad R., Wilson S.H. DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase. The Journal of biological chemistry 287(44):36702-36710, 2012.
Freudenthal B.D., Beard W.A., and Wilson S.H. DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-Oxoguanine Lesion. Nucleic acids research 41(3):1848-1858, 2013. [
Abstract
Freudenthal B.D., Beard W.A., and Wilson S.H. DNA Polymerase Minor Groove Interactions Modulate Mutagenic Bypass of a Templating 8-Oxoguanine Lesion. Nucleic acids research 41(3):1848-1858, 2013.
Horton JK, Wilson SH. Predicting Enhanced Cell Killing through PARP Inhibition. Molecular cancer research: MCR 11(1):13-18, 2013. [
Abstract
Horton JK, Wilson SH. Predicting Enhanced Cell Killing through PARP Inhibition. Molecular cancer research: MCR 11(1):13-18, 2013.
Sassa A, Beard WA, Shock DD, Wilson SH. Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity. Journal of visualized experiments: JoVE 78:e50695, 2013.  [
Abstract
Sassa A, Beard WA, Shock DD, Wilson SH. Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity. Journal of visualized experiments: JoVE 78:e50695, 2013.
Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair 2013 12(9):774-785. [
Abstract
Horton JK, Stefanick DF, Gassman NR, Williams JG, Gabel SA, Cuneo MJ, Prasad R, Kedar PS, Derose EF, Hou EW, London RE, Wilson SH. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA repair 2013 12(9):774-785.
An C, Beard WA, Chen D, Wilson SH, Makridakis NM. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer.
International journal of oncology
43(4):1131-1140, 2013. [
Abstract
An C, Beard WA, Chen D, Wilson SH, Makridakis NM. Understanding the loss-of-function in a triple missense mutant of DNA polymerase β found in prostate cancer. International journal of oncology 43(4):1131-1140, 2013.
Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell 2013 154(1):157-168. [
Abstract
Freudenthal BD, Beard WA, Shock DD, Wilson SH. Observing a DNA polymerase choose right from wrong. Cell 2013 154(1):157-168.
Chary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo
[a]
Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. PloS one 2013 8(9):e72131-. [
Abstract
Chary P, Beard WA, Wilson SH, Lloyd RS. Inhibition of HIV-1 reverse transcriptase-catalyzed synthesis by intercalated DNA Benzo
[a]
Pyrene 7,8-Dihydrodiol-9,10-Epoxide adducts. PloS one 2013 8(9):e72131-.
Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP. 2013. Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.
J Biol Chem
. 288(32):23573-85. doi: 10.1074/jbc.M113.476150. [
Abstract
Vaidyanathan VG, Liang F, Beard WA, Shock DD, Wilson SH, Cho BP. 2013. Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site. J Biol Chem. 288(32):23573-85. doi: 10.1074/jbc.M113.476150.
Horton JK, Wilson SH. 2013. Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity.
Front Oncol
. 3:257. doi: 10.3389/fonc.2013.00257. [
Abstract
Horton JK, Wilson SH. 2013. Strategic Combination of DNA-Damaging Agent and PARP Inhibitor Results in Enhanced Cytotoxicity. Front Oncol. 3:257. doi: 10.3389/fonc.2013.00257.
Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition. Molecular cancer research: MCR 2014 12(8):11281139-1139. [
Abstract
Horton JK, Stefanick DF, Prasad R, Gassman NR, Kedar PS, Wilson SH. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition. Molecular cancer research: MCR 2014 12(8):11281139-1139.
Cağlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol. 2014 May;21(5):497-9. doi: 10.1038/nsmb.2818. [
Abstract
Cağlayan M, Batra VK, Sassa A, Prasad R, Wilson SH. Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair. Nat Struct Mol Biol. 2014 May;21(5):497-9. doi: 10.1038/nsmb.2818.
Sassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem. 2014 May 16;289(20):13996-4008. [
Abstract
Sassa A, Çağlayan M, Dyrkheeva NS, Beard WA, Wilson SH. Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem. 2014 May 16;289(20):13996-4008.
Beard WA, Shock DD, Batra VK, Prasad R, Wilson SH. 2014. Substrate-induced DNA polymerase β activation.
J Biol Chem
. 289(45):31411-22. doi: 10.1074/jbc.M114.607432. [
Abstract
Beard WA, Shock DD, Batra VK, Prasad R, Wilson SH. 2014. Substrate-induced DNA polymerase β activation. J Biol Chem. 289(45):31411-22. doi: 10.1074/jbc.M114.607432.
Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one 2015 10(2):e0118819-. [
Abstract
Gassman NR, Coskun E, Stefanick DF, Horton JK, Jaruga P, Dizdaroglu M, Wilson SH. Bisphenol a promotes cell survival following oxidative DNA damage in mouse fibroblasts. PloS one 2015 10(2):e0118819-.
Çağlayan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res. 2015 Feb 27;43(4):2271-81. doi: 10.1093/nar/gkv079. [
Abstract
Çağlayan M, Horton JK, Prasad R, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Res. 2015 Feb 27;43(4):2271-81. doi: 10.1093/nar/gkv079.
Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature 2015 517(7536):635-639. [
Abstract
Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH. Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature 2015 517(7536):635-639.
Gassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair.
DNA repair
2015 31():52-63. [
Abstract
Gassman NR, Wilson SH. Micro-irradiation tools to visualize base excision repair and single-strand break repair. DNA repair 2015 31():52-63.
Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst). 2015 Nov;35:85-9. doi: 10.1016/j.dnarep.2015.09.010. Epub 2015 Sep 16. [
Abstract
Caglayan M., Wilson S.H. Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair. DNA Repair (Amst). 2015 Nov;35:85-9. doi: 10.1016/j.dnarep.2015.09.010. Epub 2015 Sep 16.
Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH. 2015. DNA polymerase β-dependent cell survival independent of XRCC1 expression.
DNA Repair (Amst)
. 26:23-9. doi: 10.1016/j.dnarep.2014.11.008. [
Abstract
Horton JK, Gassman NR, Dunigan BD, Stefanick DF, Wilson SH. 2015. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 26:23-9. doi: 10.1016/j.dnarep.2014.11.008.
Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of ribonucleotide backbone on translesion synthesis and repair of 7,8-Dihydro-8-oxoguanine.
Journal of Biological Chemistry
(2016) 291: 24314 – 24323. [
Abstract
Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M. Impact of ribonucleotide backbone on translesion synthesis and repair of 7,8-Dihydro-8-oxoguanine. Journal of Biological Chemistry (2016) 291: 24314 – 24323.
Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.
Nucleic Acids Research
(2017) 17: 10079 – 10088. [
Abstract
Caglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH. Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research (2017) 17: 10079 – 10088.
Caglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure.
Journal of Radiation Research -
Review article (2017) 1093: 1 – 5. [
Abstract
Caglayan M, Wilson SH. Role of DNA polymerase β oxidized nucleotide insertion in DNA ligation failure. Journal of Radiation Research - Review article (2017) 1093: 1 – 5.
Caglayan M, Horton JK, Da-Peng D, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.
Nature Communications
(2017) 8: 14045. [
Abstract
Caglayan M, Horton JK, Da-Peng D, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications (2017) 8: 14045.
Prasad R, Caglayan M, Da-Peng D, Nadalutti CA, Gassman NR, Zhao M, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: The missing link of the base excision repair machinery in mammalian mitochondria.
DNA Repair
(2017) 60: 77 – 88. [
Abstract
Prasad R, Caglayan M, Da-Peng D, Nadalutti CA, Gassman NR, Zhao M, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH. DNA polymerase β: The missing link of the base excision repair machinery in mammalian mitochondria. DNA Repair (2017) 60: 77 – 88.
Çağlayan M, Horton JK, Dai D-P, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair.
Nature Communications
2017 8):14045-. [
Abstract
Çağlayan M, Horton JK, Dai D-P, Stefanick DF, Wilson SH. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications 2017 8):14045-.
Perera L, Beard WA, Pedersen LG, Wilson SH. 2017. Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites.
Inorg Chem
. 56(1):313-320. doi: 10.1021/acs.inorgchem.6b02189. [
Abstract
Perera L, Beard WA, Pedersen LG, Wilson SH. 2017. Hiding in Plain Sight: The Bimetallic Magnesium Covalent Bond in Enzyme Active Sites. Inorg Chem. 56(1):313-320. doi: 10.1021/acs.inorgchem.6b02189.
Horton JK, Stefanick DF, Caglayan M, Zhao ML, Gassman NR, Wilson SH. Cellular aprataxin deadenylation activity is stimulated by phosphorylated XRCC1.
DNA Repair
(2018) – 64: 26 – 33. [
Abstract
Horton JK, Stefanick DF, Caglayan M, Zhao ML, Gassman NR, Wilson SH. Cellular aprataxin deadenylation activity is stimulated by phosphorylated XRCC1. DNA Repair (2018) – 64: 26 – 33.
Howard M, Wilson SH. DNA scanning by base excision repair enzymes and implications for pathway coordination.
DNA repair
2018 71():101-107. [
Abstract
Howard M, Wilson SH. DNA scanning by base excision repair enzymes and implications for pathway coordination. DNA repair 2018 71():101-107.
Batra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.
Biochemistry
2018 57(26):3934-3944. [
Abstract
Batra VK, Oertell K, Beard WA, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH. Mapping Functional Substrate-Enzyme Interactions in the pol β Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs. Biochemistry 2018 57(26):3934-3944.
Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.
Biochemistry
2018 57(26):3925-3933. [
Abstract
Oertell K, Kashemirov BA, Negahbani A, Minard C, Haratipour P, Alnajjar KS, Sweasy JB, Batra VK, Beard WA, Wilson SH, McKenna CE, Goodman MF. Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State. Biochemistry 2018 57(26):3925-3933.
Çağlayan M, Wilson SH. 2018. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nat Commun. 9(1):4213. doi: 10.1038/s41467-018-06700-5. [
Abstract
Çağlayan M, Wilson SH. 2018. Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals promutagenic DNA repair intermediate. Nat Commun. 9(1):4213. doi: 10.1038/s41467-018-06700-5.
Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition.
Nucleic Acids Research
2019 47(6):3197-3207. [
Abstract
Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH. A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition. Nucleic Acids Research 2019 47(6):3197-3207.
Prasad R, Horton JK, Dai DP, Wilson SH. Repair pathway for PARP-1 DNA-protein crosslinks.
DNA Repair
2019 73():71-77. [
Abstract
Prasad R, Horton JK, Dai DP, Wilson SH. Repair pathway for PARP-1 DNA-protein crosslinks. DNA Repair 2019 73():71-77.
Oertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. 2019. A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β.
Biochemistry
. 58(13):1764-1773. doi: 10.1021/acs.biochem.9b00087. [
Abstract
Oertell K, Florián J, Haratipour P, Crans DC, Kashemirov BA, Wilson SH, McKenna CE, Goodman MF. 2019. A Transition-State Perspective on Y-Family DNA Polymerase η Fidelity in Comparison with X-Family DNA Polymerases λ and β. Biochemistry. 58(13):1764-1773. doi: 10.1021/acs.biochem.9b00087.
Howard MJ, Foley KG, Shock DD, Batra VK, Wilson SH. 2019. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β.
J Biol Chem
. 294(18):7194-7201. doi: 10.1074/jbc.RA118.006809. [
Abstract
Howard MJ, Foley KG, Shock DD, Batra VK, Wilson SH. 2019. Molecular basis for the faithful replication of 5-methylcytosine and its oxidized forms by DNA polymerase β. J Biol Chem. 294(18):7194-7201. doi: 10.1074/jbc.RA118.006809.
Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. 2019. Damage sensor role of UV-DDB during base excision repair.
Nat Struct Mol Biol
. 26(8):695-703. doi: 10.1038/s41594-019-0261-7. [
Abstract
Jang S, Kumar N, Beckwitt EC, Kong M, Fouquerel E, Rapić-Otrin V, Prasad R, Watkins SC, Khuu C, Majumdar C, David SS, Wilson SH, Bruchez MP, Opresko PL, Van Houten B. 2019. Damage sensor role of UV-DDB during base excision repair. Nat Struct Mol Biol. 26(8):695-703. doi: 10.1038/s41594-019-0261-7.
Rodriguez Y, Horton JK, Wilson SH. 2019. Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles. Biochemistry. 58(35):3646-3655. [
Abstract
Rodriguez Y, Horton JK, Wilson SH. 2019. Histone H3 lysine 56 acetylation enhances AP endonuclease 1-mediated repair of AP sites in nucleosome core particles. Biochemistry. 58(35):3646-3655.
Nadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, Wilson SH. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts.
Sci Rep
2020. doi: 10.1038/s41598-020-61477-2 [Online 27 March 2020]. [
Abstract
Nadalutti CA, Stefanick DF, Zhao ML, Horton JK, Prasad R, Brooks AM, Griffith JD, Wilson SH. Mitochondrial dysfunction and DNA damage accompany enhanced levels of formaldehyde in cultured primary human fibroblasts. Sci Rep 2020. doi: 10.1038/s41598-020-61477-2 [Online 27 March 2020].
Liu Y, Rodriguez Y, Ross RL, Zhao R, Watts JA, Grunseich C, Bruzel A, Li D, Burdick JT, Prasad R, Crouch RJ, Limbach PA, Wilson SH, Cheung VG. 2020. RNA abasic sites in yeast and human cells.
Proc Natl Acad Sci U S A
; 117(34):20689-20695. [
Abstract
Liu Y, Rodriguez Y, Ross RL, Zhao R, Watts JA, Grunseich C, Bruzel A, Li D, Burdick JT, Prasad R, Crouch RJ, Limbach PA, Wilson SH, Cheung VG. 2020. RNA abasic sites in yeast and human cells. Proc Natl Acad Sci U S A; 117(34):20689-20695.
Beard WA. 2020. DNA polymerase β: Closing the gap between structure and function.
DNA Repair (Amst).
93:102910. [
Abstract
Beard WA. 2020. DNA polymerase β: Closing the gap between structure and function. DNA Repair (Amst). 93:102910.
Jiang Z, Lai Y, Beaver JM, Tsegay PS, Zhao ML, Horton JK, Zamora M, Rein HL, Miralles F, Shaver M, Hutcheson JD, Agoulnik I, Wilson SH, Liu Y. 2020. Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase. Cells. 9(1):225. doi: 10.3390/cells9010225. [
Abstract
Jiang Z, Lai Y, Beaver JM, Tsegay PS, Zhao ML, Horton JK, Zamora M, Rein HL, Miralles F, Shaver M, Hutcheson JD, Agoulnik I, Wilson SH, Liu Y. 2020. Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase β and a de novo DNA Methyltransferase. Cells. 9(1):225. doi: 10.3390/cells9010225.
Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. 2020. Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
Biochemistry
. 59(8):955-963. doi: 10.1021/acs.biochem.9b01072. [
Abstract
Batra VK, Alnajjar KS, Sweasy JB, McKenna CE, Goodman MF, Wilson SH. 2020. Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography. Biochemistry. 59(8):955-963. doi: 10.1021/acs.biochem.9b01072.
Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B. 2020. Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.
DNA Repair (Amst)
. 87:102773. doi: 10.1016/j.dnarep.2019.102773. [
Abstract
Quiñones JL, Thapar U, Wilson SH, Ramsden DA, Demple B. 2020. Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair. DNA Repair (Amst). 87:102773. doi: 10.1016/j.dnarep.2019.102773.
Perera L, Beard WA, Pedersen LG, Shock DD, Wilson SH. 2020. Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate. ACS Omega. 5(25):15317-15324. doi: 10.1021/acsomega.0c01345. [
Abstract
Perera L, Beard WA, Pedersen LG, Shock DD, Wilson SH. 2020. Preferential DNA Polymerase β Reverse Reaction with Imidodiphosphate. ACS Omega. 5(25):15317-15324. doi: 10.1021/acsomega.0c01345.
Batra VK, Wilson SH. 2020. Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus.
Commun Biol
. 3(1):348. doi: 10.1038/s42003-020-1080-4. [
Abstract
Batra VK, Wilson SH. 2020. Structure of a DNA polymerase abortive complex with the 8OG:dA base pair at the primer terminus. Commun Biol. 3(1):348. doi: 10.1038/s42003-020-1080-4.
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Last Reviewed: April 10, 2026