Molecular Endocrinology Group | National Institute of Environmental Health Sciences
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Molecular Endocrinology Group
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Molecular & Cellular Biology Laboratory
John A. Cidlowski, Ph.D.
Deputy Chief, Molecular & Cellular Biology Laboratory;
Senior Investigator
Tel 984-287-3545
[email protected]
Research Summary
The illustration depicts an overview of the group’s research.
John A. Cidlowski, Ph.D., is Deputy Chief of the Signal Transduction Laboratory and head of the Molecular Endocrinology Group.
The group studies steroid hormones, which regulate tissue-specific gene expression in animals via receptor dependent intracellular signal transduction pathways.
A second major interest of the laboratory focuses on evaluating the mechanisms involved in the regulation of apoptosis in normal and neoplastic cells. Research is aimed at the identification and cloning of genes that are responsible for both the initiation and execution of apoptosis.
Major areas of research:
Glucocorticoid receptors and their actions on the inflammatory response
Regulation of apoptosis in normal and neoplastic cells
Genetically modified animal models for studying glucocorticoid actions
Current projects:
The role of glucocorticoid receptor phosphorylation in signal transduction
The transcriptional and translational regulation of glucocorticoid receptor gene expression
The involvement of the glucocorticoid receptors in inflammation and innate immunity
Defining tissue and cell type specific roles for glucocorticoids in health and disease
The role of cell volume regulation and ion channels in apoptosis
Interview With John Cidlowski, Ph.D.
Interview with John Cidlowski, Ph.D., conducted on Sept. 8, 2017 can be found on the
NIH Office of History - NIEHS Interviews
webpage.
Cidlowski received his Ph.D. in 1975 from Medical College of Georgia in Endocrinology. He has published over 350 peer-reviewed articles in leading biomedical journals, as well as several book chapters.  He served as Professor of Physiology and Biochemistry at University of North Carolina at Chapel Hill before joining the NIEHS in 1995.
Related Links
Male hormones regulate stomach inflammation in mice
- Environmental Factor, June 2021
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Last Reviewed: April 14, 2026