Erik Tokar, Ph.D. | National Institute of Environmental Health Sciences
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Mechanistic Toxicology Branch
Erik J. Tokar, Ph.D.
Biologist
Tel 984-287-4173
[email protected]
Erik Tokar, Ph.D., leads the Stem Cell Toxicology Group in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). His group’s current research involves developing pluripotent stem cell-based models to examine
in vitro
mechanisms of developmental toxicology. The group also develops
in vitro
models of carcinogenesis which are used to investigate the roles and mechanisms of possible or known environmental human carcinogens.
Tokar obtained his Bachelor of Science in biology from University of Michigan, followed by a Ph.D. in cancer biology from Michigan State University. He did postdoctoral fellowship with NCI at NIEHS before starting his current position at DTT.
Recent Publications
Silver B, Murphy C, Tokar E, Sinha B. Ferroptosis Suppressor Protein 1 (FSP1)-CoQ10-NADPH-Axis Is Responsible for Erastin Resistance in MCF-7 Breast Cancer Cells.
Antioxidants (Basel, Switzerland)
2026 Feb 11;15(2):.
Abstract
Silver B, Murphy C, Tokar E, Sinha B. Ferroptosis Suppressor Protein 1 (FSP1)-CoQ10-NADPH-Axis Is Responsible for Erastin Resistance in MCF-7 Breast Cancer Cells. Antioxidants (Basel, Switzerland). 2026 Feb 11
Silver B, Fannin R, Gerrish K, Tokar E. Characterization of extracellular vesicles and miRNA released by cerebral organoids.
Current research in toxicology
2025;8:100229.
Abstract
Silver B, Fannin R, Gerrish K, Tokar E. Characterization of extracellular vesicles and miRNA released by cerebral organoids. Current research in toxicology. 2025
Chapman L, Hall M, Foster A, Baird D, Harmon Q, Wright R, Landero J, Heffron R, Wise L, Wegienka G, Geller R, Wesselink A, Schildroth S, Hall J, Tokar E, Upson K. Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals.
Environmental research
2025 Dec 01;286(Pt 3):122935.
Abstract
Chapman L, Hall M, Foster A, Baird D, Harmon Q, Wright R, Landero J, Heffron R, Wise L, Wegienka G, Geller R, Wesselink A, Schildroth S, Hall J, Tokar E, Upson K. Estrogen-containing contraceptive use and blood lead concentrations in a cohort of premenopausal individuals. Environmental research. 2025 Dec 01
Pacheco-Castillo N, Gómez-Montalvo J, Olivares-Illana V, Recillas-Targa F, Tokar E, Avendaño-Vázquez S, Escudero-Lourdes C. Inorganic Arsenic Induces Elevated p53 Levels with Altered Functionality Impacting the Expression of Toll-like Receptor 3 and Other Target Genes in Immortalized Prostate Epithelial Cells.
International journal of molecular sciences
2025 Apr 29;26(9):.
Abstract
Pacheco-Castillo N, Gómez-Montalvo J, Olivares-Illana V, Recillas-Targa F, Tokar E, Avendaño-Vázquez S, Escudero-Lourdes C. Inorganic Arsenic Induces Elevated p53 Levels with Altered Functionality Impacting the Expression of Toll-like Receptor 3 and Other Target Genes in Immortalized Prostate Epithelial Cells. International journal of molecular sciences. 2025 Apr 29
Wu X, Kreutz A, Dixon D, Tokar E. Engineering human cerebral organoids to explore mechanisms of arsenic-induced developmental neurotoxicity.
Toxicology and applied pharmacology
2025 Mar;496:117230.
Abstract
Wu X, Kreutz A, Dixon D, Tokar E. Engineering human cerebral organoids to explore mechanisms of arsenic-induced developmental neurotoxicity. Toxicology and applied pharmacology. 2025 Mar
NTP Reports
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12
NTP Research Reports
2019 Jul [Epub ahead of print].
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul
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Last Reviewed: December 19, 2025