Frank G. Chao, Ph.D. | National Institute of Environmental Health Sciences
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Toxicoinformatics Group
Frank G. Chao, Ph.D.
Computational Biologist
Tel 984-287-4066
[email protected]
Frank Chao, Ph.D., is a Computational Biologist in the Predictive Toxicology Branch of the Division of Translational Toxicology (DTT). His primary responsibilities include developing and applying methods to identify relationships between apical toxicological effects and transcriptional responses in target organs. He leverages R’s powerful statistical capabilities and advanced visualization tools to predict metabolic pathways in humans based on rat in vivo microarray expression data, utilizing the Enrichr application.
Before joining DTT in 2019, Chao earned his B.S. in Biology from Peking University in China and his Ph.D. in Toxicology from the University of Missouri at Columbia. He then worked at Duke University Medical Center from 2002 to 2005, focusing on detecting single nucleotide polymorphisms (SNPs). Starting in May 2005, he joined the NIEHS research groups in the Molecular Genetics Core Facility and the Clinical Research Unit (CRU), where he concentrated on pulmonary gene analysis and patient sample data until December 2019.
Recent Publications
Cong G, Patton R, Chao F, Svoboda D, Erickson J, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S. Transplatformer: translating toxicogenomic profiles between generations of platforms.
BMC bioinformatics
2026 Jan 30;27(1):.
Abstract
Cong G, Patton R, Chao F, Svoboda D, Erickson J, Balik-Meisner M, Mav D, Phadke D, Scholl E, Shah R, Auerbach S. Transplatformer: translating toxicogenomic profiles between generations of platforms. BMC bioinformatics. 2026 Jan 30
Richter K, Burch L, Chao F, Henke D, Jiang C, Daly J, Zhao M, Kissling G, Diaz M. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein.
The Journal of biological chemistry
2012 Sep 14;287(38):31856-65.
Abstract
Richter K, Burch L, Chao F, Henke D, Jiang C, Daly J, Zhao M, Kissling G, Diaz M. Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein. The Journal of biological chemistry. 2012 Sep 14
Burch L, Zhang L, Chao F, Xu H, Drake J. The bacteriophage T4 rapid-lysis genes and their mutational proclivities.
Journal of bacteriology
2011 Jul;193(14):3537-45.
Abstract
Burch L, Zhang L, Chao F, Xu H, Drake J. The bacteriophage T4 rapid-lysis genes and their mutational proclivities. Journal of bacteriology. 2011 Jul
Burch L, Yang Y, Sterling J, Roberts S, Chao F, Xu H, Zhang L, Walsh J, Resnick M, Mieczkowski P, Gordenin D. Damage-induced localized hypermutability.
Cell cycle (Georgetown, Tex.)
2011 Apr 01;10(7):1073-85.
Abstract
Burch L, Yang Y, Sterling J, Roberts S, Chao F, Xu H, Zhang L, Walsh J, Resnick M, Mieczkowski P, Gordenin D. Damage-induced localized hypermutability. Cell cycle (Georgetown, Tex.). 2011 Apr 01
Burch L, Yang I, Whitehead G, Chao F, Berman K, Schwartz D. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment.
American journal of physiology. Lung cellular and molecular physiology
2006 Oct;291(4):L677-82.
Abstract
Burch L, Yang I, Whitehead G, Chao F, Berman K, Schwartz D. The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. American journal of physiology. Lung cellular and molecular physiology. 2006 Oct
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Last Reviewed: December 19, 2025