Christopher McPherson, Ph.D. | National Institute of Environmental Health Sciences

Christopher McPherson, Ph.D. | National Institute of Environmental Health Sciences
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Christopher McPherson, Ph.D.
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Mechanistic Toxicology Branch
Christopher A. McPherson, Ph.D.
Biologist
Tel 984-287-4185
[email protected]
Christopher McPherson, Ph.D. is a staff scientist in the NIEHS Division of Translational Toxicology (DTT) in the Mechanistic Toxicology Branch. He specializes in neurotoxicology and neurobiology. Christopher McPherson’s research examines
in vitro
and
in vivo
mechanisms of neurotoxicity throughout the lifespan, with a focus on characterizing inflammatory and molecular alterations due to contaminant exposure. His other interests include the use of high-throughput and high-content models to assess the neurotoxic potential of chemicals.
Christopher McPherson obtained his B.S. in Life Sciences from Arizona State University, followed by a Ph.D. in Toxicology from the University of North Carolina at Chapel Hill.
Recent Publications
Kendricks D, Stallone J, Thomas D, Aksu L, Kirkwood-Donelson K, Jarmusch A, McPherson C, Cushman J. Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice.
Neurotoxicology
2025 Sep;110:132-144.
Abstract
Kendricks D, Stallone J, Thomas D, Aksu L, Kirkwood-Donelson K, Jarmusch A, McPherson C, Cushman J. Neurobehavioral and metabolic effects of prenatal low-dose chlorpyrifos in C57BL/6J mice. Neurotoxicology. 2025 Sep
Kanungo J, Sorkin B, Krzykwa J, Mitchell C, Embry M, Spencer P, Harry G, Cannon J, Liu F, McPherson C, Gafner S, Westerink R. Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety.
Expert opinion on drug metabolism & toxicology
2024 Jul;20(7):629-646.
Abstract
Kanungo J, Sorkin B, Krzykwa J, Mitchell C, Embry M, Spencer P, Harry G, Cannon J, Liu F, McPherson C, Gafner S, Westerink R. Screening tools to evaluate the neurotoxic potential of botanicals: building a strategy to assess safety. Expert opinion on drug metabolism & toxicology. 2024 Jul
McPherson C, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry G. High Content Imaging and Quantification of Microglia Phagocytosis In Vitro.
Current protocols
2023 Jan;3(1):e638.
Abstract
McPherson C, Kelly-Rajan K, Lefebvre d'Hellencourt C, Harry G. High Content Imaging and Quantification of Microglia Phagocytosis In Vitro. Current protocols. 2023 Jan
Bowen C, Childers G, Perry C, Martin N, McPherson C, Lauten T, Santos J, Harry G. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells.
Chemosphere
2020 Sep;255:126919.
Abstract
Bowen C, Childers G, Perry C, Martin N, McPherson C, Lauten T, Santos J, Harry G. Mitochondrial-related effects of pentabromophenol, tetrabromobisphenol A, and triphenyl phosphate on murine BV-2 microglia cells. Chemosphere. 2020 Sep
Goulding D, Kraft A, Mouton P, McPherson C, Avdoshina V, Mocchetti I, Harry G. Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats.
Neurotoxicity research
2019 Oct;36(3):563-582.
Abstract
Goulding D, Kraft A, Mouton P, McPherson C, Avdoshina V, Mocchetti I, Harry G. Age-Related Decrease in Tyrosine Hydroxylase Immunoreactivity in the Substantia Nigra and Region-Specific Changes in Microglia Morphology in HIV-1 Tg Rats. Neurotoxicity research. 2019 Oct
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Last Reviewed: December 19, 2025