Michelle J. Hooth, Ph.D., D.A.B.T. | National Institute of Environmental Health Sciences
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Michelle J. Hooth, Ph.D., D.A.B.T.
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Office of Program Operations
Michelle J. Hooth, Ph.D., D.A.B.T.
Deputy Director for Program Operations, Division of Translational Toxicology;
Director, Office of Program Operations
Tel 984-202-4309
[email protected]
Michelle Hooth, Ph.D., D.A.B.T. is a toxicologist and Director of the Office of Program Operations in the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. The Office of Program Operations provides tactical support for the DTT research portfolio by coordinating and managing intramural and research and development budgets, contracts and Interagency Agreements, providing program/project management expertise, and delivering certain Division-shared services like chemistry, ADME/TK, and scientific reporting of DTT/NTP’s research. Hooth is responsible for directing the work of chemists and toxicologists that also implement research activities under DTT contracts.
Hooth manages and participates in multidisciplinary teams of NIEHS/DTT scientists to develop research programs to address a broad array of toxicological study needs. She led initiatives to understand the potential toxicity and carcinogenicity of hexavalent chromium, cobalt, botanical dietary supplements and drinking water disinfection by-products and contributes to numerous peer-reviewed technical reports providing scientific data to regulatory agencies and the public.
Hooth received a B.S. (summa cum laude) in Biological Sciences from Michigan State University in 1990 and a Ph.D. in Toxicology from the University of North Carolina at Chapel Hill in 1996. She completed postdoctoral training in the Environmental Carcinogenesis Division of the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency. She joined the NTP in 2000 and became a Diplomate of the American Board of Toxicology (ABT) in 2003. She has served on various committees of the Society of Toxicology and is a prior ABT Board Member.
Recent Publications
Wyde M, Capstick M, Hall S, Hooth M, Kuster N, Ladbury J, Roberts G, Shipkowski K, Shockley K, Smith-Roe S, Stout M, Walker N. Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents
2025 Aug [Epub ahead of print].
Abstract
Wyde M, Capstick M, Hall S, Hooth M, Kuster N, Ladbury J, Roberts G, Shipkowski K, Shockley K, Smith-Roe S, Stout M, Walker N. Development and Testing of a Novel Whole-body Exposure System for Investigative Studies of Radiofrequency Radiation in Rodents . 2025 Aug
Soucy N, Masten S, Caro C, Arthur A, Moore N, Hooth M, Mitkus R. Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice.
International journal of toxicology
2023 Sep;42(5):430-444.
Abstract
Soucy N, Masten S, Caro C, Arthur A, Moore N, Hooth M, Mitkus R. Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice. International journal of toxicology. 2023 Sep
Waidyanatha S, Weber F, Fallacara D, Harrington J, Levine K, Robinson V, Sparrow B, Stout M, Fernando R, Hooth M, Xie G, Roberts G. Corrigendum to "Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water" [Toxicol. Lett. 360 (2022) 53-61].
Toxicology letters
2023 Jan 15;373:210.
Abstract
Waidyanatha S, Weber F, Fallacara D, Harrington J, Levine K, Robinson V, Sparrow B, Stout M, Fernando R, Hooth M, Xie G, Roberts G. Corrigendum to "Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water" [Toxicol. Lett. 360 (2022) 53-61]. Toxicology letters. 2023 Jan 15
Waidyanatha S, Weber F, Fallacara D, Harrington J, Levine K, Robinson V, Sparrow B, Stout M, Fernando R, Hooth M, Xie G, Roberts G. Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water.
Toxicology letters
2022 May 01;360:53-61.
Abstract
Waidyanatha S, Weber F, Fallacara D, Harrington J, Levine K, Robinson V, Sparrow B, Stout M, Fernando R, Hooth M, Xie G, Roberts G. Systemic exposure and urinary excretion of vanadium following perinatal subchronic exposure to vanadyl sulfate and sodium metavanadate via drinking water. Toxicology letters. 2022 May 01
Frawley R, Germolec D, Johnson V, Gulledge T, Manheng W, White K, Shockley K, Harris S, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids.
Journal of applied toxicology : JAT
2022 Mar;42(3):392-408.
Abstract
Frawley R, Germolec D, Johnson V, Gulledge T, Manheng W, White K, Shockley K, Harris S, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. Journal of applied toxicology : JAT. 2022 Mar
NTP Reports
National Toxicology Program. Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice.
Toxicity report series
2024 Oct [Epub ahead of print].
Abstract
National Toxicology Program. Toxicity study of Stachybotrys chartarum (CASRN 67892-26-6) administered by inhalation to B6C3F1/N mice. Toxicity report series. 2024 Oct
National Toxicology Program. Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice.
National Toxicology Program technical report series
2023 Dec [Epub ahead of print].
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of black cohosh root extract (CASRN 84776-26-1) administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats and female B6C3F1/N mice. National Toxicology Program technical report series. 2023 Dec
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
National Toxicology Program technical report series
2023 Jun [Epub ahead of print].
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.
Toxicity report series
2023 Mar [Epub ahead of print].
Abstract
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar
National Toxicology Program. Toxicity studies of sodium metavanadate and vanadyl sulfate administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Toxicity report series
2023 Feb [Epub ahead of print].
Abstract
National Toxicology Program. Toxicity studies of sodium metavanadate and vanadyl sulfate administered in drinking water to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity report series. 2023 Feb
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Last Reviewed: February 20, 2026