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Ionization Sources: Electrospray Ionization (ESI), Heated Electrospray Ionization (HESI), Nanoelectrospray Ionization (NSI), Atmospheric Pressure Chemical Ionization (APCI)
Chromatography: Nano-scale Flow Liquid Chromatography (NanoLC), Ultra-high Performance Liquid Chromatography (UHPLC), Supercritical Fluid Chromatography (SFC)
Ion Mobility Spectrometry (IMS): Trapped Ion Mobility Spectrometry (TIMS)
Mass Spectrometry (MS): Triple Quadrupole MS (QqQ), Quadrupole Time-of-Flight (qToF), Orbitrap (Orbi)
Tandem Mass Spectrometry (MS/MS or MSn): collision-induced dissociation (CID), higher-energy collisional dissociation (HCD), electron transfer dissociation (ETD)
Measurement Systems
High Resolution Mass Spectrometry (HRMS)
Ion Mobility Spectrometry – Mass Spectrometry (IMS-MS)
Ultra-high Performance Liquid Chromatography – Mass Spectrometry (UHPLC-MS)
Ultra-high Performance Liquid Chromatography – High Resolution Mass Spectrometry (UHPLC-HRMS)
Ultra-high Performance Liquid Chromatography – High Resolution Tandem Mass Spectrometry (UHPLC-HRMS/MS)
Ultra-high Performance Liquid Chromatography – Ion Mobility Spectrometry – Mass Spectrometry (UPHLC-IMS-MS)
Ultra-high Performance Liquid Chromatography – Ion Mobility Spectrometry – Tandem Mass Spectrometry (UPHLC-IMS-MS/MS)
Equipment
Thermo Vanquish Horizon UHPLC – Thermo Orbitrap Fusion Tribrid MS
Thermo Vanquish Horizon UHPLC – Thermo Orbitrap Fusion Lumos Tribrid MS
Thermo Vanquish Neo UHPLC – Thermo Orbitrap Ascend Tribrid MS with ETD
Thermo Vanquish Horizon UHPLC – Thermo Q Exactive+ MS
Waters Acquity M-Class nano-UPLC – Thermo Q Exactive+ MS
Thermo Vanquish Horizon UHPLC – Thermo TSQ Quantiva Triple Quadrupole MS
Dionex UltiMate 3000 UHPLC – Thermo TSQ Qantive Triple Quadrupole MS
Bruker Elute UHPLC – Bruker timsTOF Pro MS • Shimadzu LC-40D – SCIEX 7500 Triple Quadrupole MS
Shimadzu LC-40D – SCIEX 7500 Triple Quadrupole MS
SCIEX Exion UHPLC – SCIEX 6500+ QTrap MS with SelexION differential mobility filter
Thermo Trace 1300 GC – Thermo TSQ 8000 Triple Quadrupole MS
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Last Reviewed: February 18, 2026