David M. Crizer, Ph.D. | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/mtb/staff/crizer
Archived: 2026-04-23 17:30
David M. Crizer, Ph.D. | National Institute of Environmental Health Sciences
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David M. Crizer, Ph.D.
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Mechanistic Toxicology Branch
David M. Crizer, Ph.D.
Chemist
Tel 984-287-4221
[email protected]
David Crizer, Ph.D., is a chemist in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Before joining DTT he completed his doctorate in Analytical Chemistry at the University of North Carolina at Chapel Hill under the direction of Gary Glish. At UNC his dissertation research focused on the use of mass spectrometry, differential ion mobility, and theoretical chemistry to understand novel ion chemistries.
His work at DTT is focused on the development of mass spectrometry-based untargeted metabolomic methods to aid in the screening of potentially toxic substances. His research also includes analytical method development for hepatic clearance assays, specific activity assays, and metabolite profiling assays. Other interests include the investigation of in silico metabolite prediction and how predictions compare to
in vitro
data.
Crizer obtained his B.S. in Chemistry from James Madison University followed by a Ph.D. in Analytical Chemistry from University of North Carolina at Chapel Hill.
Recent Publications
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems.
Toxicological sciences : an official journal of the Society of Toxicology
.
2026 Mar 02;209(3):.
[
Abstract
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems. Toxicological sciences : an official journal of the Society of Toxicology. 2026 Mar 02
]
Scherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays.
Environmental science & technology
.
2026 Feb 17;60(6):4869-4877.
[
Abstract
Scherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays. Environmental science & technology. 2026 Feb 17
]
Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories.
Toxics
.
2024 Sep 14;12(9):.
[
Abstract
Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14
]
Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay.
Chemical research in toxicology
.
2024 Jun 17;37(6):923-934.
[
Abstract
Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay. Chemical research in toxicology. 2024 Jun 17
]
Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.
Archives of toxicology
.
2024 Apr;98(4):1111-1123.
[
Abstract
Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr
]
NTP Reports
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul
]
More Recent Publications from PubMed
Related Links
Insight into how metabolites affect health aided by new data platforms
- Environmental Factor, January 2022
To study metabolome, a hybrid approach is needed, expert says
- Environmental Factor, August 2021
Novel toxicity assessment strategies highlighted at DNTP board meeting
- Environmental Factor, July 2021
Back
to Top
Last Reviewed: December 19, 2025
Skip Navigation
David M. Crizer, Ph.D.
Close the left navigation
Add
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Mechanistic Toxicology Branch
David M. Crizer, Ph.D.
Chemist
Tel 984-287-4221
[email protected]
David Crizer, Ph.D., is a chemist in the Mechanistic Toxicology Branch, Division of Translational Toxicology (DTT). Before joining DTT he completed his doctorate in Analytical Chemistry at the University of North Carolina at Chapel Hill under the direction of Gary Glish. At UNC his dissertation research focused on the use of mass spectrometry, differential ion mobility, and theoretical chemistry to understand novel ion chemistries.
His work at DTT is focused on the development of mass spectrometry-based untargeted metabolomic methods to aid in the screening of potentially toxic substances. His research also includes analytical method development for hepatic clearance assays, specific activity assays, and metabolite profiling assays. Other interests include the investigation of in silico metabolite prediction and how predictions compare to
in vitro
data.
Crizer obtained his B.S. in Chemistry from James Madison University followed by a Ph.D. in Analytical Chemistry from University of North Carolina at Chapel Hill.
Recent Publications
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems.
Toxicological sciences : an official journal of the Society of Toxicology
.
2026 Mar 02;209(3):.
[
Abstract
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems. Toxicological sciences : an official journal of the Society of Toxicology. 2026 Mar 02
]
Scherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays.
Environmental science & technology
.
2026 Feb 17;60(6):4869-4877.
[
Abstract
Scherer M, Feshuk M, Armitage J, Arnot J, Crizer D, DeVito M, Ferguson S, Freeman K, Honda G, Harrill J, Sangion A, Tebes-Stevens C, Paul Friedman K, Wambaugh J. Characterizing Accuracy of Model Predictions for Chemical Concentration in High Throughput Screening Assays. Environmental science & technology. 2026 Feb 17
]
Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories.
Toxics
.
2024 Sep 14;12(9):.
[
Abstract
Crizer D, Rice J, Smeltz M, Lavrich K, Ravindra K, Wambaugh J, DeVito M, Wetmore B. In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories. Toxics. 2024 Sep 14
]
Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay.
Chemical research in toxicology
.
2024 Jun 17;37(6):923-934.
[
Abstract
Sostare E, Bowen T, Lawson T, Freier A, Li X, Lloyd G, Najdekr L, Jankevics A, Smith T, Varshavi D, Ludwig C, Colbourne J, Weber R, Crizer D, Auerbach S, Bucher J, Viant M. Metabolomics Simultaneously Derives Benchmark Dose Estimates and Discovers Metabolic Biotransformations in a Rat Bioassay. Chemical research in toxicology. 2024 Jun 17
]
Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.
Archives of toxicology
.
2024 Apr;98(4):1111-1123.
[
Abstract
Viant M, Amstalden E, Athersuch T, Bouhifd M, Camuzeaux S, Crizer D, Driemert P, Ebbels T, Ekman D, Flick B, Giri V, Gómez-Romero M, Haake V, Herold M, Kende A, Lai F, Leonards P, Lim P, Lloyd G, Mosley J, Namini C, Rice J, Romano S, Sands C, Smith M, Sobanski T, Southam A, Swindale L, van Ravenzwaay B, Walk T, Weber R, Zickgraf F, Kamp H. Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice. Archives of toxicology. 2024 Apr
]
NTP Reports
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul
]
More Recent Publications from PubMed
Related Links
Insight into how metabolites affect health aided by new data platforms
- Environmental Factor, January 2022
To study metabolome, a hybrid approach is needed, expert says
- Environmental Factor, August 2021
Novel toxicity assessment strategies highlighted at DNTP board meeting
- Environmental Factor, July 2021
Back
to Top
Last Reviewed: December 19, 2025