Portfolio Strategy | National Institute of Environmental Health Sciences

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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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Office of Portfolio Strategy and Research Management
Scott A. Masten, Ph.D.
Director, Office of Portfolio Strategy & Research Management
Tel 984-287-3156
[email protected]
Scott Masten, Ph.D., D.A.B.T., is Director of Office of Portfolio Strategy within Office of Portfolio Strategy and Research Management within the Division of the Translational Toxicology at the National Institute of Environmental Health Sciences (NIEHS). His primary responsibility is implementing a strategic research portfolio that efficiently and effectively leverages the breadth of Divisional scientific capabilities and advances the scientific mission of the DTT. Other important activities within the OPS include portfolio, program and project management, analysis and evaluation, and coordination of priority scientific initiatives within the Division.
In research prioritization and planning, Masten actively interfaces with a variety of stakeholders on public health issues of national and international significance. He engages with scientific advisory committees, federal and state agencies, commercial entities and advocacy organizations. He represents the NIEHS and NTP on interagency coordinating groups focused on a range of topics including disaster research and dietary supplements, and the National Science and Technology Council (NSTC) Sustainable Chemistry Strategy Team.
Masten is a Diplomate of the
American Board of Toxicology
and has broad research interests in toxicology testing strategies, predictive toxicology, safer alternatives, and regulatory decision-making. Masten received a B.S. in Marine Biology from the University of North Carolina at Wilmington and his Ph.D. in Pharmacology and Toxicology from the University of Florida. He came to NIEHS in 1995 for post-doctoral training in the Laboratory of Computational Biology and Risk Analysis and joined the NIEHS as a Research Fellow in 1998.
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ResearchGate
Recent Publications
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems.
Toxicological sciences : an official journal of the Society of Toxicology
2026 Mar 02;209(3):.
Abstract
Smith-Roe S, DeVito M, Co C, Ramaiahgari S, Easterling M, Rice J, Dunlap P, Crizer D, Zhou Z, Merrick B, Xie G, Harris S, Shockley K, Tandon A, Oktay A, Mav D, Shah R, Borrel A, Gombar V, Masten S, Paules R, Ferguson S. Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems. Toxicological sciences : an official journal of the Society of Toxicology. 2026 Mar 02
Panzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11
NIEHS Report Series
2024 Oct [Epub ahead of print].
Abstract
Panzacchi S, Belpoggi F, Bua L, Bucher J, Cora M, De Angelis L, Falcioni L, Gnudi F, Mandrioli D, Manservigi M, Manzoli I, Masten S, Menghetti I, Mutlu E, Roberts G, Shipkowski K, Sills R, Stout M, Strollo V, Tibaldi E, Tracy J, Vornoli A, Waidyanatha S. NIEHS Report on the Toxicity Studies of Nicotine Bitartrate Dihydrate (CASRN 6019-06-3) Administered in Drinking Water to Sprague Dawley Rats and Swiss Mice: NIEHS Report 11 NIEHS Report Series. 2024 Oct
Soucy N, Masten S, Caro C, Arthur A, Moore N, Hooth M, Mitkus R. Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice.
International journal of toxicology
2023 Sep;42(5):430-444.
Abstract
Soucy N, Masten S, Caro C, Arthur A, Moore N, Hooth M, Mitkus R. Updating the Standards of Professional Competence in the Field of Toxicology: The Second Generation of Best Practice. International journal of toxicology. 2023 Sep
Shipkowski K, Cora M, Cesta M, Robinson V, Waidyanatha S, Witt K, Vallant M, Fallacara D, Hejtmancik M, Masten S, Cooper S, Fernando R, Blystone C. Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage.
Toxicology reports
2021;8:581-591.
Abstract
Shipkowski K, Cora M, Cesta M, Robinson V, Waidyanatha S, Witt K, Vallant M, Fallacara D, Hejtmancik M, Masten S, Cooper S, Fernando R, Blystone C. Comparison of sulfolane effects in Sprague Dawley rats, B6C3F1/N mice, and Hartley guinea pigs after 28 days of exposure via oral gavage. Toxicology reports. 2021
Pelch K, Wignall J, Goldstone A, Ross P, Blain R, Shapiro A, Holmgren S, Hsieh J, Svoboda D, Auerbach S, Parham F, Masten S, Walker V, Rooney A, Thayer K. A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives.
Toxicology
2019 Aug 01;424:152235.
Abstract
Pelch K, Wignall J, Goldstone A, Ross P, Blain R, Shapiro A, Holmgren S, Hsieh J, Svoboda D, Auerbach S, Parham F, Masten S, Walker V, Rooney A, Thayer K. A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives. Toxicology. 2019 Aug 01
NTP Reports
National Toxicology Program. NTP Immunotoxicity Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice: Immunotoxicity Report 01
NTP Immunotoxicity Reports
2020 Jul [Epub ahead of print].
Abstract
National Toxicology Program. NTP Immunotoxicity Technical Report on the Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) and Crude 4-Methylcyclohexanemethanol Administered Topically to Female BALB/c Mice: Immunotoxicity Report 01 NTP Immunotoxicity Reports. 2020 Jul
National Toxicology Program. NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): DART Report 02
NTP Developmental and Reproductive Toxicity Reports
2020 Jun [Epub ahead of print].
Abstract
National Toxicology Program. NTP Developmental and Reproductive Toxicity Technical Report on the Prenatal Development Studies of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies): DART Report 02 NTP Developmental and Reproductive Toxicity Reports. 2020 Jun
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Toxicity report series
2019 Aug [Epub ahead of print].
Abstract
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Toxicity report series. 2019 Aug
National Toxicology Program. Toxicity studies of perfluoroalkyl carboxylates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Toxicity report series
2019 Aug [Epub ahead of print].
Abstract
National Toxicology Program. Toxicity studies of perfluoroalkyl carboxylates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Toxicity report series. 2019 Aug
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14
NTP Research Reports
2019 Jul [Epub ahead of print].
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14 NTP Research Reports. 2019 Jul
More Recent Publications from PubMed
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Pamela Bayles
Contractor
Tel 984-287-4497
[email protected]
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Last Reviewed: December 22, 2025