William Gwinn, Ph.D. | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/stb/staff/gwinn
Archived: 2026-04-23 17:31
William Gwinn, Ph.D. | National Institute of Environmental Health Sciences
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Systems Toxicology Branch
William M. Gwinn, Ph.D.
Biologist
Tel 984-287-4216
[email protected]
William Gwinn, Ph.D. is an inhalation toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. He serves as a study scientist for chemicals selected for toxicity and carcinogenicity evaluation by the NTP. His expertise is in respiratory toxicology, immunology, and inflammation, and he serves primarily as a project lead for inhalation studies within the DTT including the application of in vitro lung models to inhalation toxicology.
Gwinn received a B.S. in Biology from The College of William and Mary, Williamsburg, VA in 1997, a M.S. in Pathology from Duke University, Durham, NC in 2001, and a Ph.D. in Immunology from The George Washington University School of Medicine and Health Sciences, Washington, DC in 2006. He completed postdoctoral training at Duke University and within the DIR and DNTP at NIEHS.
Recent Publications
Le Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays.
Archives of toxicology
.
2026 Mar 05 [Epub ahead of print].
[
Abstract
Le Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays. Archives of toxicology. 2026 Mar 05
]
Cao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives.
In vitro cellular & developmental biology. Animal
.
2021 Feb;57(2):104-132.
[
Abstract
Cao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives. In vitro cellular & developmental biology. Animal. 2021 Feb
]
Gwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes.
Toxicological sciences : an official journal of the Society of Toxicology
.
2020 Aug 01;176(2):343-354.
[
Abstract
Gwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicological sciences : an official journal of the Society of Toxicology. 2020 Aug 01
]
Morgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10
NTP Research Reports
.
2019 Aug [Epub ahead of print].
[
Abstract
Morgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10 NTP Research Reports. 2019 Aug
]
Gwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7
NTP Research Reports
.
2018 Dec [Epub ahead of print].
[
Abstract
Gwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7 NTP Research Reports. 2018 Dec
]
NTP Reports
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2023 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar
]
National Toxicology Program. Toxicity studies of trimethylsilyldiazomethane administered by nose-only inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Toxicity report series
.
2021 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of trimethylsilyldiazomethane administered by nose-only inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity report series. 2021 Mar
]
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Toxicity report series. 2020 Jul
]
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14 NTP Research Reports. 2019 Jul
]
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul
]
More Recent Publications from PubMed
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Last Reviewed: December 18, 2025
Skip Navigation
William Gwinn, Ph.D.
Close the left navigation
Add
Systems Toxicology Branch
William M. Gwinn, Ph.D.
Biologist
Tel 984-287-4216
[email protected]
William Gwinn, Ph.D. is an inhalation toxicologist in the Systems Toxicology Branch of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences. He serves as a study scientist for chemicals selected for toxicity and carcinogenicity evaluation by the NTP. His expertise is in respiratory toxicology, immunology, and inflammation, and he serves primarily as a project lead for inhalation studies within the DTT including the application of in vitro lung models to inhalation toxicology.
Gwinn received a B.S. in Biology from The College of William and Mary, Williamsburg, VA in 1997, a M.S. in Pathology from Duke University, Durham, NC in 2001, and a Ph.D. in Immunology from The George Washington University School of Medicine and Health Sciences, Washington, DC in 2006. He completed postdoctoral training at Duke University and within the DIR and DNTP at NIEHS.
Recent Publications
Le Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays.
Archives of toxicology
.
2026 Mar 05 [Epub ahead of print].
[
Abstract
Le Y, Sun Y, Li X, Wynne R, Twaddle N, Bishop M, Beland F, Gwinn W, Heflich R, Cao X, Wang Y. Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays. Archives of toxicology. 2026 Mar 05
]
Cao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives.
In vitro cellular & developmental biology. Animal
.
2021 Feb;57(2):104-132.
[
Abstract
Cao X, Coyle J, Xiong R, Wang Y, Heflich R, Ren B, Gwinn W, Hayden P, Rojanasakul L. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives. In vitro cellular & developmental biology. Animal. 2021 Feb
]
Gwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes.
Toxicological sciences : an official journal of the Society of Toxicology
.
2020 Aug 01;176(2):343-354.
[
Abstract
Gwinn W, Auerbach S, Parham F, Stout M, Waidyanatha S, Mutlu E, Collins B, Paules R, Merrick B, Ferguson S, Ramaiahgari S, Bucher J, Sparrow B, Toy H, Gorospe J, Machesky N, Shah R, Balik-Meisner M, Mav D, Phadke D, Roberts G, DeVito M. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicological sciences : an official journal of the Society of Toxicology. 2020 Aug 01
]
Morgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10
NTP Research Reports
.
2019 Aug [Epub ahead of print].
[
Abstract
Morgan D, Flake G, Gwinn W, Johnson C. NTP Research Report on Respiratory Tract Toxicity of the Flavoring Agent 2,3-Hexanedione in Mice Exposed by Inhalation: Research Report 10 NTP Research Reports. 2019 Aug
]
Gwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7
NTP Research Reports
.
2018 Dec [Epub ahead of print].
[
Abstract
Gwinn W, Bousquet R, Perry C, Urbano N, Auerbach S. NTP Research Report on the Preliminary Evaluation of 4-Methylcyclohexylmethanol in an In Vitro Human Airway Model: Research Report 7 NTP Research Reports. 2018 Dec
]
NTP Reports
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2023 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar
]
National Toxicology Program. Toxicity studies of trimethylsilyldiazomethane administered by nose-only inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Toxicity report series
.
2021 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of trimethylsilyldiazomethane administered by nose-only inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity report series. 2021 Mar
]
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Toxicity report series. 2020 Jul
]
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: 14-Day Exposure Characterization Studies of Crumb Rubber in Female Mice Housed on Mixed Bedding or Dosed via Feed or Oral Gavage: Research Report 14 NTP Research Reports. 2019 Jul
]
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12
NTP Research Reports
.
2019 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. NTP Research Report on Synthetic Turf/Recycled Tire Crumb Rubber: Characterization of the Biological Activity of Crumb Rubber In Vitro: Research Report 12 NTP Research Reports. 2019 Jul
]
More Recent Publications from PubMed
Back
to Top
Last Reviewed: December 18, 2025