The Digitized Atlas of Mouse Liver Lesions | National Institute of Environmental Health Sciences

The Digitized Atlas of Mouse Liver Lesions | National Institute of Environmental Health Sciences
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The Digitized Atlas of Mouse Liver Lesions
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
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This Digitized Atlas of Mouse Liver Lesions provides color photomicrographs illustrating examples of some spontaneous, aging as well as chemically induced non-neoplastic and neoplastic histopathological hepatobiliary lesions commonly observed in B6C3F1 and Genetically Modified mice from acute, subchronic and chronic toxicity and/or carcinogenicity studies conducted by the
National Toxicology Program
. In addition to the color photomicrographs, content includes internationally accepted (standardized) diagnostic nomenclature as well of descriptions for some of the lesions.
Search by Pathology:
Normal
Congenital Lesions of the Liver
Degenerative Lesions of the Liver
Necrotic, Inflammatory and Vascular Lesions of the Liver
Hyperplastic and Neoplastic Lesions of the Liver
Bile Duct Hyperplasia - Intravascular Hepatocytes
Hemangioma - Histiocytic Sarcoma
Lipomatous Lesions - Malignant Melanoma
Oval Cell Hyperplasia - Ovarian Teratomas
Miscellaneous Lesions of the Liver
Toxicologic Lesions of the Liver
Lesions of the Gallbladder
Unique Liver Lesions of Genetically Altered Mice
Filter by First Letter:
A
Adenoma
Alb-uPA mice - hepatocellular adenoma
Alb-uPA mice - nodular regeneration
Alb-uPA transgenic mice
AL-TAg mice
AL-ras x AL-myc bitransgenic mice
AL-TAgxAL-myc dual transgenic mice
AL-TAgxAL-myc mice - anaplasia
AL-TAgxAL-myc mice - biliary cysts
AL-TAgxAL-myc mice - basophilic focus
AL-TAgxAL-myc mice - bile duct adenocarcinoma
AL-TAgxAL-myc mice - bile duct adenoma
AL-TAgxAL-myc mice - bile duct proliferation
AL-TAgxAL-myc mice - bromodeoxyuridine
AL-TAgxAL-myc mice - cholangiocarcinoma
AL-TAgxAL-myc mice - ductular formation
AL-TAgxAL-myc mice - foci of cellular alteration
AL-TAgxAL-myc mice - hepatocellular adenoma
AL-TAgxAL-myc mice - hepatocellular carcinoma
AL-TAgxAL-myc mice - hepatocellular neoplasm
AL-TAgxAL-myc mice - hepatocytomegaly
AL-TAgxAL-myc mice - karyomegaly
Amyloidosis
Anaplasia - AL-TAgxAL-myc mice
Anaplasia of hepatocytes & oval cell proliferation
Angiectasis
Apoptosis
Apoptosis - TGF alpha mice
Apoptotic bodies
B
Basophilic focus
Basophilic focus - AL-TAgxAL-myc mice
Bile duct adenocarcinoma - AL-TAgxAL-myc mice
Bile duct adenoma - AL-TAgxAL-myc mice
Bile duct hyperplasia
Bile duct proliferation - AL-TAgxAL-myc mice
Biliary cysts - AL-TAgxAL-myc mice
Binucleate hepatocytes
Bromodeoxyuridine - AL-TAgxAL-myc mice
C
Carcinoma in adenoma
Chlordane
Cholangiocarcinoma
Cholangiocarcinoma - AL-TAgxAL-myc mice
Cholangiocarcinoma - scirrhous reaction
Cholangioma
Cholecystitis
Clear cell focus
Coagulation necrosis
Congenital lesions of the liver
Crystalline inclusions - gallbladder
Cyst - gallbladder
Cystic degeneration
Cytomegaly
Cytomegaly associated with chlordane exposure
Cytomegaly associated with Helicobacter
Cytomegaly of hepatocytes & oval cell proliferation<
Cytoplasmic alteration
Cytoplasmic vacuolation
D
Degeneration of hepatocytes & oval cell proliferation
Degenerative lesions of the liver
Ductular formation - AL-TAg mice
Ductual formation - AL-TAgxAL-myc mice
Dysplasia - AL-TAg mice
E
Ectopic kidney
Ectopic pancreas in the gallbladder
Endothelial cell proliferation
Endothelial hyperplasia
Eosinophilic focus
Erythroleukemia
Erythroleukemia - Tg.AC mice
Erythrophagocytosis
Erythropoiesis
Extramedullary hematopoiesis
F
Fatty change
Fatty metamorphosis
Focus
Focus of cellular alteration
Focus of cellular alteration - AL-TAgxAL-myc mice
G
Gallbladder
Gallbladder - crystalline inclusions
Gallbladder - cyst
Gallbladder - ectopic pancreas
Gallbladder - hyaline degeneration
Gallbladder - hyperplasia
Gallbladder - inclusions
Gallbladder - inflammation
Gallbladder - papillary adenoma
Gallbladder - papillary hyperplasia
Genetically altered mice
Giant cells in histiocytic sarcoma
Glycogen Deposition
H
HBV transgenic mice
HBV transgenic mice - hepatic neoplasia, gross
HBV transgenic mice - hepatocellular adenoma
Helicobacter hepaticus
Hemangioma
Hemangiosarcoma
Hematopoiesis
Hepatic atrophy with Ito cell tumors
Hepatitis
Hepatitis B
Hepatoblastoma
Hepatocellular adenoma
Hepatocellular adenoma - Alb-uPA mice
Hepatocellular adenoma - AL-TAgxAL-myc mice
Hepatocellular adenoma - HBV transgenic mice
Hepatocellular adenoma - TGFalpha mice
Hepatocellular carcinoma
Hepatocellular carcinoma - AL-TAgxAL-myc mice
Hepatocellular hypertrophy
Hepatocholangiocarcinoma
Hepatocyte atrophy with hemangiosarcoma
Hepatocyte degeneration in fatty change
Hepatocytomegaly - AL-TAgxAL-myc mice
Hepatocytomegaly - TGF alpha mice
Hepatodiaphragmatic nodule
Hepatopathy
Histiocytic sarcoma
Histiocytosis
Hyaline bodies
Hyaline change
Hyaline degeneration
Hyaline degeneration - gallbladder
Hyperplasia - gallbladder
Hyperplastic lesions of the liver
I
Inclusions - gallbladder
Infarct
Inflammation - gallbladder
Inflammatory lesions of the liver
Intrahepatic erythrocytes
Intravascular hepatocytes
Ito cells in cystic degeneration
Ito cell lesions
Ito cell tumor
K
Karyomegaly associated with Helicobacter
Karyomegaly associated with oval cell hyperplasia
Karyomegaly associated with cytomegaly
Karyomegaly - AL-TAgxAL-myc mice
Karyomegaly - TGFalpha mice
Kupffer cell hyperplasia
Kupffer cell hyperplasia - toxic change
Kupffer cell pigment
Kupffer cell sarcoma
L
Lipomatous lesions
Lymphoma
Lymphosarcoma
M
Malignant lymphoma
Malignant melanoma
Mast cell tumor
Melanoma
Metastatic tumor, ovarian teratoma
Metastatic tumor, malignant melanoma
Metastatic tumor, lymphoma
Microgranuloma
Microinvasion
Microvesicular fatty change
Miscellaneous lesions of the liver
Mixed focus
Myelodysplasia - Tg.AC mice
Myelopoiesis
Myeloproliferation - Tg.AC mice
N
Necrosis
Necrotic lesions of the liver
Neoplastic lesions of the liver
Nodular regeneration - Alb-uPA mice
Normal gallbladder
Normal liver, fixation, fasted
Normal liver, fixation, nonfasted
Normal liver vs. polyploidy
Normal liver, gross
Normal liver, lobes
Normal liver, perfused, nonfasted
O
Oval cell hyperplasia
Oval cell hyperplasia - toxic change
Oval cell proliferation associated with Helicobacter
Ovarian teratoma
P
Papillary adenoma - gallbladder
Papillary hyperplasia - gallbladder
Peliosis associated with hemangiosarcoma
Peliosis hepatis
Perisinusoidal lining cells
Periodic acid Schiff stain
Pigment - toxic change
Ploidy
Polyploidy
Polyploidy associated with apoptosis
Polyploidy associated with hepatocyte hypertrophy
Pseudoinclusion with oval cell hyperplasia
S
Sarcoma, NOS
Scirrhous reaction - cholangiocarcinoma
Spongiosis hepatis
T
Telangiectasis
Tension lipidosis
Teratoma
Tg.AC mice
TGF alpha mice - apoptosis
Tg.AC mice - myeloproliferation
Tg.AC mice - myelodysplasia
Tg.AC mice - erythroleukemia
TGF alpha
TGF alpha mice
TGF alpha mice - hepatocellular adenoma
TGF alpha mice - hepatomegaly
TGF alpha mice - karyomegaly
Torsion
Toxic change
Toxic change - Kupffer cell hyperplasia
Toxic change - oval cell hyperplasia
Toxic change - pigment
Toxicologic lesions of the liver
Trabecular carcinoma
Transgenic mice
Transgenic mice - Alb-uPA mice
Transgenic mice - AL-TAg mice
Transgenic mice - AL-TAgxAL-myc
Transgenic mice - AL-ras x AL-myc
Transgenic mice - HBV
Transgenic mice - hepatocellular adenoma
Transgenic mice - Tg.AC mice
Transgenic mice - TGF alpha
U
Urokinase-plasminogen activator
V
Vacuolated focus
Vacuolation
Vascular lesions of the liver
Contact
Ronald A. Herbert, D.V.M., Ph.D., F.I.A.T.P.
Senior Scientist;
Head, Pathology Support Group, Comparative & Molecular Pathogenesis Branch
Tel 984-287-3841
[email protected]
Related Links
Cellular & Molecular Pathology - Digital Imaging/Analysis
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Last Reviewed: December 22, 2025