Pathology Support Group | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/cmp/path-support
Archived: 2026-04-23 17:39
Pathology Support Group | National Institute of Environmental Health Sciences
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Pathology Support Group
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Necropsy, Histology, Electron Microscopy, Immunohistochemistry, & Imaging Sciences
Ronald A. Herbert, D.V.M., Ph.D., F.I.A.T.P.
Senior Scientist;
Head, Pathology Support Group, Comparative & Molecular Pathogenesis Branch
Tel 984-287-3841
[email protected]
Research Summary
The Pathology Support Group, within the Comparative & Molecular Pathogenesis Branch, provides technical, collaborative and consultative pathology support for NIEHS research programs. For over 25 years, the Pathology Support Group has been a valuable resource for research programs throughout the NIEHS Division of Intramural Research (DIR) and the Division of Translational Toxicology (DTT). The Group consists of five technical laboratories that are essential components of the DTT and NIEHS research programs.
Our primary mission is to maintain a group of centralized, in-house, pathology Core Laboratories that use the latest technologies to provide a broad range of critical cost effective, routine and specialized, pathology related, technical support for research programs across NIEHS. In addition to technical support, the group also serves as a consultative and collaborative resource for NIEHS scientists related to the technical services provided.
The Group consists of five core laboratories, including:
Electron Microscopy
Histology
Imaging Sciences
Digital Imaging
Artificial Intelligence
lmmunohistochemistry
Necropsy
The laboratories are staffed by highly experienced, professional, and technical personnel that include board certified, veterinary toxicologic pathologists, technical biologists, and on-site technical contractors.
Ronald Herbert, D.V.M., Ph.D., F.I.A.T.P., leads the Pathology Support Group within the Comparative & Molecular Pathogenesis Branch. He is a veterinary pathologist with over 30 years’ experience in anatomic and diagnostic toxicologic pathology and pathology peer review of short- and long-term rodent toxicity and carcinogenicity studies. Herbert is a graduate of Tuskegee University where he earned Bachelor of Science degrees in Biology, and Animal and Poultry Science, and a Doctor of Veterinary Medicine (D.V.M.) from the Tuskegee University College of Veterinary Medicine in 1985. He completed a residency/fellowship and a Ph.D. in anatomic and comparative pathology at the Purdue University School of Veterinary Medicine, graduating in 1991. Subsequently, Herbert completed a 3-year postdoctoral fellowship in toxicologic pathology in the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS) and joined as an NTP staff scientist in 1994. He has authored or co-authored numerous peer-reviewed articles in leading biomedical journals as well as several book chapters and NTP technical reports . His areas of interest include chemical-induced toxicity and carcinogenesis, and toxicologic pathology with emphasis in pathology peer review, and pathology of the respiratory and female reproductive systems, digital pathology and Artificial Intelligence for qualitative and quantitative pathology evaluations and analyses.
Core Laboratory Capabilities
Electron Microsopy
Consultation
Digital Micrographics
Interpretive Evaluation
Grid Preparation
Report Preparation
TEM and SEM
Tissue Collection
Tissue Embedding
Resin
Tissue Fixation
Tissue Microtomy
Thick (500-800nm)
Thin (70-90nm)
Tissue Processing
Manual/Automated
Tissue Staining
Toluidine Blue
Uranyl Acetate/Lead Citrate
Ultrastructural Microscopy
Histology
100% Quality Control
Consultation
Histopathological Evaluation
CMPB Pathologists
Contractor Pathologists
Report Preparation
Tissue Embedding
Paraffin Only
Tissue Microtomy
Tissue Processing
Automated
Tissue Staining
Manual/Automated
Routine H&E
Specialized
Unstained Sections
Imaging Sciences
Consultation
Digital Imaging
Whole Slide Scanning
Image Processing
Image Analysis and Artificial Intelligence
Qualitative/Quantitative Analysis
Deep/Machine Learning
Create CNN Algorithms
Report Preparation
Immunohistochemistry
Consultation
Cryosectioning
Development/Optimizations
Commercially Available Antibodies
Novel Antibodies
Evaluation and Interpretation
Immunofluorescence
Report Preparation
RNAscope
Routine Stains
Commercially Available Antibodies
Tissue Staining
Cell Pellets/Suspensions
Cyto Preps
FFPE Tissue
Frozen Tissue
Manual/Automated
Organoids
Single and Dual
Necropsy
Blood Collection
Body Weights/Organ Weights
Bone Decalcifying
Complete/Partial
Consultation
Cryopreservation
Gross Photography
Tissue Collection
Sterile Media
RNAse Free
Freezing
Tissue Fixation
Immersion
Whole-Body Perfusion
Tissue Trimming
Recent Publications
Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype.
Experimental and molecular pathology
.
2022 Oct;128:104812.
[
Abstract
Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct
]
Ton T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice.
Archives of toxicology
.
2021 Oct;95(10):3171-3190.
[
Abstract
Ton T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice. Archives of toxicology. 2021 Oct
]
Jiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Journal of immunology (Baltimore, Md. : 1950)
.
2021 May 15;206(10):2468-2477.
[
Abstract
Jiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2021 May 15
]
Riva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice.
Nature genetics
.
2020 Nov;52(11):1189-1197.
[
Abstract
Riva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice. Nature genetics. 2020 Nov
]
Willard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.
Toxicologic pathology
.
2019 Aug;47(6):665-783.
[
Abstract
Willard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicologic pathology. 2019 Aug
]
NTP Reports
National Toxicology Program. Toxicity studies of fullerene C60 (1 μm and 50 nm) administered by nose-only inhalation to Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of fullerene C60 (1 μm and 50 nm) administered by nose-only inhalation to Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice. Toxicity report series. 2020 Jul
]
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Toxicity report series. 2020 Jul
]
National Toxicology Program. Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
National Toxicology Program technical report series
.
2020 May [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). National Toxicology Program technical report series. 2020 May
]
National Toxicology Program. Toxicity studies of 1020 Long Multiwalled Carbon Nanotubes (L-MWNT-1020) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Toxicity report series
.
2019 Nov [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of 1020 Long Multiwalled Carbon Nanotubes (L-MWNT-1020) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity report series. 2019 Nov
]
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Toxicity report series
.
2019 Aug [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Toxicity report series. 2019 Aug
]
More Recent Publications from PubMed
Related Links
The Digitized Atlas of Mouse Liver Lesions
NTP Nonneoplastic Lesion Atlas
NTP Rodent Ultrastructure Atlas
Scientists and Staff
Back
to Top
Last Reviewed: December 29, 2025
Skip Navigation
Pathology Support Group
Close the left navigation
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Necropsy, Histology, Electron Microscopy, Immunohistochemistry, & Imaging Sciences
Ronald A. Herbert, D.V.M., Ph.D., F.I.A.T.P.
Senior Scientist;
Head, Pathology Support Group, Comparative & Molecular Pathogenesis Branch
Tel 984-287-3841
[email protected]
Research Summary
The Pathology Support Group, within the Comparative & Molecular Pathogenesis Branch, provides technical, collaborative and consultative pathology support for NIEHS research programs. For over 25 years, the Pathology Support Group has been a valuable resource for research programs throughout the NIEHS Division of Intramural Research (DIR) and the Division of Translational Toxicology (DTT). The Group consists of five technical laboratories that are essential components of the DTT and NIEHS research programs.
Our primary mission is to maintain a group of centralized, in-house, pathology Core Laboratories that use the latest technologies to provide a broad range of critical cost effective, routine and specialized, pathology related, technical support for research programs across NIEHS. In addition to technical support, the group also serves as a consultative and collaborative resource for NIEHS scientists related to the technical services provided.
The Group consists of five core laboratories, including:
Electron Microscopy
Histology
Imaging Sciences
Digital Imaging
Artificial Intelligence
lmmunohistochemistry
Necropsy
The laboratories are staffed by highly experienced, professional, and technical personnel that include board certified, veterinary toxicologic pathologists, technical biologists, and on-site technical contractors.
Ronald Herbert, D.V.M., Ph.D., F.I.A.T.P., leads the Pathology Support Group within the Comparative & Molecular Pathogenesis Branch. He is a veterinary pathologist with over 30 years’ experience in anatomic and diagnostic toxicologic pathology and pathology peer review of short- and long-term rodent toxicity and carcinogenicity studies. Herbert is a graduate of Tuskegee University where he earned Bachelor of Science degrees in Biology, and Animal and Poultry Science, and a Doctor of Veterinary Medicine (D.V.M.) from the Tuskegee University College of Veterinary Medicine in 1985. He completed a residency/fellowship and a Ph.D. in anatomic and comparative pathology at the Purdue University School of Veterinary Medicine, graduating in 1991. Subsequently, Herbert completed a 3-year postdoctoral fellowship in toxicologic pathology in the National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS) and joined as an NTP staff scientist in 1994. He has authored or co-authored numerous peer-reviewed articles in leading biomedical journals as well as several book chapters and NTP technical reports . His areas of interest include chemical-induced toxicity and carcinogenesis, and toxicologic pathology with emphasis in pathology peer review, and pathology of the respiratory and female reproductive systems, digital pathology and Artificial Intelligence for qualitative and quantitative pathology evaluations and analyses.
Core Laboratory Capabilities
Electron Microsopy
Consultation
Digital Micrographics
Interpretive Evaluation
Grid Preparation
Report Preparation
TEM and SEM
Tissue Collection
Tissue Embedding
Resin
Tissue Fixation
Tissue Microtomy
Thick (500-800nm)
Thin (70-90nm)
Tissue Processing
Manual/Automated
Tissue Staining
Toluidine Blue
Uranyl Acetate/Lead Citrate
Ultrastructural Microscopy
Histology
100% Quality Control
Consultation
Histopathological Evaluation
CMPB Pathologists
Contractor Pathologists
Report Preparation
Tissue Embedding
Paraffin Only
Tissue Microtomy
Tissue Processing
Automated
Tissue Staining
Manual/Automated
Routine H&E
Specialized
Unstained Sections
Imaging Sciences
Consultation
Digital Imaging
Whole Slide Scanning
Image Processing
Image Analysis and Artificial Intelligence
Qualitative/Quantitative Analysis
Deep/Machine Learning
Create CNN Algorithms
Report Preparation
Immunohistochemistry
Consultation
Cryosectioning
Development/Optimizations
Commercially Available Antibodies
Novel Antibodies
Evaluation and Interpretation
Immunofluorescence
Report Preparation
RNAscope
Routine Stains
Commercially Available Antibodies
Tissue Staining
Cell Pellets/Suspensions
Cyto Preps
FFPE Tissue
Frozen Tissue
Manual/Automated
Organoids
Single and Dual
Necropsy
Blood Collection
Body Weights/Organ Weights
Bone Decalcifying
Complete/Partial
Consultation
Cryopreservation
Gross Photography
Tissue Collection
Sterile Media
RNAse Free
Freezing
Tissue Fixation
Immersion
Whole-Body Perfusion
Tissue Trimming
Recent Publications
Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype.
Experimental and molecular pathology
.
2022 Oct;128:104812.
[
Abstract
Dunnick J, Pandiri A, Shockley K, Herbert R, Mav D, Phadke D, Shah R, Merrick B. Single nucleotide polymorphism patterns associated with a cancer resistant phenotype. Experimental and molecular pathology. 2022 Oct
]
Ton T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice.
Archives of toxicology
.
2021 Oct;95(10):3171-3190.
[
Abstract
Ton T, Kovi R, Peddada T, Chhabria R, Shockley K, Flagler N, Gerrish K, Herbert R, Behl M, Hoenerhoff M, Sills R, Pandiri A. Cobalt-induced oxidative stress contributes to alveolar/bronchiolar carcinogenesis in B6C3F1/N mice. Archives of toxicology. 2021 Oct
]
Jiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Journal of immunology (Baltimore, Md. : 1950)
.
2021 May 15;206(10):2468-2477.
[
Abstract
Jiang C, Zhao M, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M. The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma. Journal of immunology (Baltimore, Md. : 1950). 2021 May 15
]
Riva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice.
Nature genetics
.
2020 Nov;52(11):1189-1197.
[
Abstract
Riva L, Pandiri A, Li Y, Droop A, Hewinson J, Quail M, Iyer V, Shepherd R, Herbert R, Campbell P, Sills R, Alexandrov L, Balmain A, Adams D. The mutational signature profile of known and suspected human carcinogens in mice. Nature genetics. 2020 Nov
]
Willard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System.
Toxicologic pathology
.
2019 Aug;47(6):665-783.
[
Abstract
Willard-Mack C, Elmore S, Hall W, Harleman J, Kuper C, Losco P, Rehg J, Rühl-Fehlert C, Ward J, Weinstock D, Bradley A, Hosokawa S, Pearse G, Mahler B, Herbert R, Keenan C. Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System. Toxicologic pathology. 2019 Aug
]
NTP Reports
National Toxicology Program. Toxicity studies of fullerene C60 (1 μm and 50 nm) administered by nose-only inhalation to Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of fullerene C60 (1 μm and 50 nm) administered by nose-only inhalation to Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice. Toxicity report series. 2020 Jul
]
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats.
Toxicity report series
.
2020 Jul [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of abrasive blasting agents administered by inhalation to F344/NTac rats and Sprague Dawley (Hsd:Sprague Dawley SD) Rats. Toxicity report series. 2020 Jul
]
National Toxicology Program. Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
National Toxicology Program technical report series
.
2020 May [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). National Toxicology Program technical report series. 2020 May
]
National Toxicology Program. Toxicity studies of 1020 Long Multiwalled Carbon Nanotubes (L-MWNT-1020) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
Toxicity report series
.
2019 Nov [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of 1020 Long Multiwalled Carbon Nanotubes (L-MWNT-1020) administered by inhalation to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. Toxicity report series. 2019 Nov
]
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised).
Toxicity report series
.
2019 Aug [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of perfluoroalkyl sulfonates administered by gavage to Sprague Dawley (Hsd:Sprague Dawley SD) rats (revised). Toxicity report series. 2019 Aug
]
More Recent Publications from PubMed
Related Links
The Digitized Atlas of Mouse Liver Lesions
NTP Nonneoplastic Lesion Atlas
NTP Rodent Ultrastructure Atlas
Scientists and Staff
Back
to Top
Last Reviewed: December 29, 2025