Laser Capture Microdissection Group | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/cmp/laser-capture
Archived: 2026-04-23 17:10
Laser Capture Microdissection Group | National Institute of Environmental Health Sciences
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Laser Capture Microdissection Group
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Arun Kumar R. Pandiri, B.V.Sc. & A.H., M.S., Ph.D., D.A.C.V.P., D.A.B.T.
Group Leader - Pathologist
Tel 984-287-3861
[email protected]
Laser Microdissection core laboratory aids in the extraction of defined cells and tissues to allow target-based research. The laboratory will also assist in the extraction of DNA, RNA or protein from specific cells or tissues of interest to aid the NIEHS investigators in their research. The LCM lab works closely with the Pathology Support Core Laboratory, Microarray Core Laboratory, Epigenomics and DNA Sequencing Core Laboratory and Mass Spectrometry Research and Support Group to develop protocols for the analysis of biomolecules in frozen or formalin-fixed paraffin-embedded tissues.
Recent Publications
Wu X, Williams J, Liang H, Gruzdev A, Hartsell J, Shpargel J, Mainali R, Fang Y, Ji M, Duval C, Xu X, Zhang Z, Winter H, Pediaditakis P, Pandiri A, Migaud M, Jarmusch A, Yu H, Liu X, Li J, Xu X, Shats I, Li X. NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis.
Nature communications
.
2026 Feb 10 [Epub ahead of print].
[
Abstract
Wu X, Williams J, Liang H, Gruzdev A, Hartsell J, Shpargel J, Mainali R, Fang Y, Ji M, Duval C, Xu X, Zhang Z, Winter H, Pediaditakis P, Pandiri A, Migaud M, Jarmusch A, Yu H, Liu X, Li J, Xu X, Shats I, Li X. NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis. Nature communications. 2026 Feb 10
]
Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion.
Cell reports
.
2025 Jul 22;44(7):115978.
[
Abstract
Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 22
]
Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models.
Cancer research
.
2025 May 15;85(10):1769-1783.
[
Abstract
Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer research. 2025 May 15
]
Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.
PloS one
.
2024;19(1):e0296699.
[
Abstract
Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024
]
Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver.
Toxicologic pathology
.
2023 Oct;51(7-8):470-481.
[
Abstract
Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver. Toxicologic pathology. 2023 Oct
]
NTP Reports
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
National Toxicology Program technical report series
.
2023 Jun [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun
]
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2023 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar
]
National Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies).
National Toxicology Program technical report series
.
2018 Jun [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2018 Jun
]
National Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies).
National Toxicology Program technical report series
.
2017 Dec [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2017 Dec
]
National Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies).
National Toxicology Program technical report series
.
2016 Apr [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Apr
]
More Recent Publications from PubMed
Back
to Top
Last Reviewed: December 29, 2025
Skip Navigation
Laser Capture Microdissection Group
Close the left navigation
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Arun Kumar R. Pandiri, B.V.Sc. & A.H., M.S., Ph.D., D.A.C.V.P., D.A.B.T.
Group Leader - Pathologist
Tel 984-287-3861
[email protected]
Laser Microdissection core laboratory aids in the extraction of defined cells and tissues to allow target-based research. The laboratory will also assist in the extraction of DNA, RNA or protein from specific cells or tissues of interest to aid the NIEHS investigators in their research. The LCM lab works closely with the Pathology Support Core Laboratory, Microarray Core Laboratory, Epigenomics and DNA Sequencing Core Laboratory and Mass Spectrometry Research and Support Group to develop protocols for the analysis of biomolecules in frozen or formalin-fixed paraffin-embedded tissues.
Recent Publications
Wu X, Williams J, Liang H, Gruzdev A, Hartsell J, Shpargel J, Mainali R, Fang Y, Ji M, Duval C, Xu X, Zhang Z, Winter H, Pediaditakis P, Pandiri A, Migaud M, Jarmusch A, Yu H, Liu X, Li J, Xu X, Shats I, Li X. NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis.
Nature communications
.
2026 Feb 10 [Epub ahead of print].
[
Abstract
Wu X, Williams J, Liang H, Gruzdev A, Hartsell J, Shpargel J, Mainali R, Fang Y, Ji M, Duval C, Xu X, Zhang Z, Winter H, Pediaditakis P, Pandiri A, Migaud M, Jarmusch A, Yu H, Liu X, Li J, Xu X, Shats I, Li X. NAPRT-mediated deamidated NAD biosynthesis enhances colon tissue resiliency and suppresses tumorigenesis. Nature communications. 2026 Feb 10
]
Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion.
Cell reports
.
2025 Jul 22;44(7):115978.
[
Abstract
Xu M, Li J, Hsiao Y, Kovi R, Li J, Klimczak L, Riva L, Adams D, Bushel P, Merrick B, Gordenin D, Bucher J, Sills R, Pandiri A. Environmental carcinogens often exacerbate endogenous mutagenic processes to enhance tumor promotion. Cell reports. 2025 Jul 22
]
Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models.
Cancer research
.
2025 May 15;85(10):1769-1783.
[
Abstract
Cai L, Wu F, Zhou Q, Gao Y, Yao B, DeBerardinis R, Acquaah-Mensah G, Aidinis V, Beane J, Biswal S, Chen T, Concepcion-Crisol C, Grüner B, Jia D, Jones R, Kurie J, Lee M, Lindahl P, Lissanu Y, Lorz C, MacPherson D, Martinelli R, Mazur P, Mazzilli S, Mii S, Moll H, Moorehead R, Morrisey E, Ng S, Oser M, Pandiri A, Powell C, Ramadori G, Santos M, Snyder E, Sotillo R, Su K, Taki T, Taparra K, Tran P, Xia Y, van Veen J, Winslow M, Xiao G, Rudin C, Oliver T, Xie Y, Minna J. The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models. Cancer research. 2025 May 15
]
Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel.
PloS one
.
2024;19(1):e0296699.
[
Abstract
Brooks A, Vornoli A, Kovi R, Ton T, Xu M, Mashal A, Tibaldi E, Gnudi F, Li J, Sills R, Bucher J, Mandrioli D, Belpoggi F, Pandiri A. Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. PloS one. 2024
]
Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver.
Toxicologic pathology
.
2023 Oct;51(7-8):470-481.
[
Abstract
Pandiri A, Auerbach S, Stevens J, Blomme E. Toxicogenomics Approaches to Address Toxicity and Carcinogenicity in the Liver. Toxicologic pathology. 2023 Oct
]
NTP Reports
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice.
National Toxicology Program technical report series
.
2023 Jun [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of an isomeric mixture of tris(chloropropyl) phosphate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice. National Toxicology Program technical report series. 2023 Jun
]
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice.
Toxicity report series
.
2023 Mar [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of acetoin and 2,3-pentanedione administered by inhalation to Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice. Toxicity report series. 2023 Mar
]
National Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies).
National Toxicology Program technical report series
.
2018 Jun [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of p-chloro-α,α,α-trifluorotoluene in Sprague Dawley (Hsd:Sprague Dawley SD) rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2018 Jun
]
National Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies).
National Toxicology Program technical report series
.
2017 Dec [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology and carcinogenesis studies of antimony trioxide in Wistar Han [Crl:WI (Han)] rats and B6C3F1/N mice (inhalation studies). National Toxicology Program technical report series. 2017 Dec
]
National Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies).
National Toxicology Program technical report series
.
2016 Apr [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicology studies of green tea extract in F344/NTac rats and B6C3F1/N mice and toxicology and carcinogenesis studies of green tea extract in Wistar Han [Crl:WI(Han)] rats and B6C3F1/N mice (gavage studies). National Toxicology Program technical report series. 2016 Apr
]
More Recent Publications from PubMed
Back
to Top
Last Reviewed: December 29, 2025