MRC Laboratory of Molecular Biology
Source: http://www.mrc-centre.cam.ac.uk
Archived: 2026-04-23 15:31
MRC Laboratory of Molecular Biology
LMB email addresses have changed to @mrclmb.ac.uk
Discovering
how life works
This 3D rendering shows the neural connections in a fruit fly brain, which is less than 1 mm across.
Read more about the rendering, Greg Jefferis’s group and the FlyWire Consortium
.
Research that spans the breadth of biology
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of fundamental biological processes at the levels of atoms, molecules, cells and organisms. The knowledge we provide is crucial to solving key problems in human health.
Our Science
A 3D image of the human replisome, the molecular machinery that copies our DNA, captured using electron cryomicroscopy.
Discover more about the research exploring how these complexes work
.
Latest News
LMB News
Manu Hegde elected to the American Academy of Arts and Sciences
LMB News
Race Equality Lead Nic Farmer receives their CMI Level 6 Award in Professional Management and Leadership Practice
LMB News
Showcasing the intricate beauty of biology at the Cambridge Festival
Insight on Research
First telomerase structure identified in yeast
Insight on Research
A long and dangerous journey: how primordial germ cells migrate in mouse embryos
LMB News
Madeline Lancaster wins 2026 Suffrage Science Award
View All
Next
An unsurpassed environment for researchers
The LMB comprises over 50 scientific groups pursuing ambitious research, supported by cutting-edge scientific facilities and generous core-funding by the MRC/UKRI. We occupy an inspiring, purpose-built building on the thriving Cambridge Biomedical Campus.
Working at the LMB
Public Engagement
How we connect with society and inspire the next generation.
Upcoming Events
other seminar
23 / 04 / 2026
International Women’s Day Talk: Professor Julie Ahringer
Julie Ahringer, University of Cambridge
lmb seminar
27 / 04 / 2026
LMB Seminar: Mechanisms of mRNA packaging and export
Clemens Plaschka, Research Institute of Molecular Pathology, Vienna
divisional seminar
01 / 05 / 2026
Stabilization of excised introns in yeast
Glenn Wei Li, Whitehead Institute and MIT
lmb named seminar
11 / 05 / 2026
César Milstein Lecture: Life with Two X Chromosomes: mechanisms of silencing and escape during X-chromosome inactivation
Edith Heard, CEO, Francis Crick Institute
divisional seminar
12 / 05 / 2026
Structural Complexity
Dr Sebastian Ahnert, Department of Chemical Engineering & Biotechnology, University of Cambridge
lmb named seminar
18 / 05 / 2026
CANCELLED John Kendrew Lecture
Elena Conti, Max Planck Institute of Biochemistry
View All
Next
Progressing science for over 60 years
Since our origins in 1947, the LMB has pioneered the molecular biology revolution and is a world-leading source of new ideas, scientific advances and technology. Our discoveries have led to highly successful commercialisations and medical advances that have improved human life.
Explore Our History Timeline
An axon bundle growing from a human brain organoid within a micropatterned device.
Read more about research into axon growth and human brain development
.
Latest Publications
Assembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts.
(20th Apr 2026)
Nellaepalli S, Baretić D, Brandner AF, Kubis-Waller S, Xu D, Soufi Z, Cheng S, Kodru S, Fang J, Flores-Pérez Ú, Ravikumar V, Pulido P, Fournier M, Ahel I, Khalid S, Jarvis RP
Nat Commun
• doi: 10.1038/s41467-026-71676-6
Songbird connectome reveals tunneling of migratory neurons in the adult striatum.
(17th Apr 2026)
Shvedov NR, Castonguay SJ, Rother A, Schick DE, Kornfeld J, Scott BB
Curr Biol
• doi: 10.1016/j.cub.2026.03.057
Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge.
(17th Apr 2026)
Makuyana N, Seldeslachts L, Michiels L, Burton OT, Hernandez AR, Ghodsinia A, Rahman E, Kops LM, Singh K, Naranjo F, Ali M, Dashwood A, Achkir M, Kouser L, Lienart S, Guillaume S, Naesens L, Linterman MA, Wauters J, Joulia R, Humblet-Baron S, Vande Velde G, Dooley J, Liston A
Sci Immunol
• 11(118):eadv7969 • doi: 10.1126/sciimmunol.adv7969
Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex.
(4th May 2026)
Turner NN, Zhang Z, Yang J, Muir KW, McLaughlin SH, Morgan T, Barford D
J Cell Biol
• 225(5) • doi: 10.1083/jcb.202506015
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.
Burr SP, Auckland K, Glynos A, Dhawanjewar A, Ryall C, Wei W, Hynes-Allen A, Prater M, Sczaniecka-Clift M, Prudent J, Chinnery PF, van den Ameele J
Nat Struct Mol Biol
• 33(4):711-723 • doi: 10.1038/s41594-026-01779-7
MDA5 generates compact ribonucleoprotein complexes via ATP-dependent double-stranded RNA unwinding.
(19th Mar 2026)
Quack S, Maity S, America PPB, Klein M, Herrero Del Valle A, Singh R, Joiner JD, Rashid ZM, Smitskamp Q, Rivas P, Papini FS, Broedersz CP, Roos WH, Modis Y, Dulin D
Nucleic Acids Res
• 54(6) • doi: 10.1093/nar/gkag274
Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines.
(20th Apr 2026)
Pavlinek A, Guerrisi S, O'Driscoll K, Polit LD, Nagy R, Lancaster MA, Vernon AC, Srivastava DP
Cell Rep Methods
• 6(4):101371 • doi: 10.1016/j.crmeth.2026.101371
Adhesion G protein-coupled receptors.
(16th Jan 2026)
Langenhan T, Anderson GR, Araç D, Aust G, Avila-Zozaya M, Bagger SM, Barth P, Berndt S, Blacklow SC, Blanco-Redondo B, Boucard AA, Bridges JP, Brodmerkel LS, Caron KM, Chung YK, Dates AN, de Araujo Farias V, Del Toro D, Duman JG, Engel FB, Favara DM, Formstone CJ, Fu C, Garcia De Las Bayonas A, Georgiadi A, Gloriam DE, Hall RA, Hamann J, Hildebrand PW, Hsiao CC, Huang BX, Javitch JA, Kim HY, Kittel RJ, Kleinau G, Leduc R, Liebscher I, Lin HH, Linnert J, Ludwig MG, Martinelli DC, Mathiasen S, Matúš D, Melkumyan M, Moreno-Salinas AL, Mulder J, Nash MA, Pal K, Pederick DT, Perry-Hauser NA, Piao X, Ping YQ, Placantonakis DG, Pohl F, Prömel S, Rosenkilde MM, Sabbagh L, Sando RC, Scheerer P, Schöneberg T, Seiradake E, Selcho M, Seufert F, Singh AK, Skiniotis G, Spiess K, Sträter N, Strutt D, Südhof TC, Sun J, Tall GG, Thor D, Tilley DG, Tolias KF, Vallon M, Van Meir EG, Vanhollebeke B, Wiggin GR, Wolfrum U, Yan J, Zaidman NA, Zou Y, Scholz N
Pharmacol Rev
• 78(3):100116 • doi: 10.1016/j.pharmr.2026.100116
Search Published Research
Loading...
LMB email addresses have changed to @mrclmb.ac.uk
Discovering
how life works
This 3D rendering shows the neural connections in a fruit fly brain, which is less than 1 mm across.
Read more about the rendering, Greg Jefferis’s group and the FlyWire Consortium
.
Research that spans the breadth of biology
The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of fundamental biological processes at the levels of atoms, molecules, cells and organisms. The knowledge we provide is crucial to solving key problems in human health.
Our Science
A 3D image of the human replisome, the molecular machinery that copies our DNA, captured using electron cryomicroscopy.
Discover more about the research exploring how these complexes work
.
Latest News
LMB News
Manu Hegde elected to the American Academy of Arts and Sciences
LMB News
Race Equality Lead Nic Farmer receives their CMI Level 6 Award in Professional Management and Leadership Practice
LMB News
Showcasing the intricate beauty of biology at the Cambridge Festival
Insight on Research
First telomerase structure identified in yeast
Insight on Research
A long and dangerous journey: how primordial germ cells migrate in mouse embryos
LMB News
Madeline Lancaster wins 2026 Suffrage Science Award
View All
Next
An unsurpassed environment for researchers
The LMB comprises over 50 scientific groups pursuing ambitious research, supported by cutting-edge scientific facilities and generous core-funding by the MRC/UKRI. We occupy an inspiring, purpose-built building on the thriving Cambridge Biomedical Campus.
Working at the LMB
Public Engagement
How we connect with society and inspire the next generation.
Upcoming Events
other seminar
23 / 04 / 2026
International Women’s Day Talk: Professor Julie Ahringer
Julie Ahringer, University of Cambridge
lmb seminar
27 / 04 / 2026
LMB Seminar: Mechanisms of mRNA packaging and export
Clemens Plaschka, Research Institute of Molecular Pathology, Vienna
divisional seminar
01 / 05 / 2026
Stabilization of excised introns in yeast
Glenn Wei Li, Whitehead Institute and MIT
lmb named seminar
11 / 05 / 2026
César Milstein Lecture: Life with Two X Chromosomes: mechanisms of silencing and escape during X-chromosome inactivation
Edith Heard, CEO, Francis Crick Institute
divisional seminar
12 / 05 / 2026
Structural Complexity
Dr Sebastian Ahnert, Department of Chemical Engineering & Biotechnology, University of Cambridge
lmb named seminar
18 / 05 / 2026
CANCELLED John Kendrew Lecture
Elena Conti, Max Planck Institute of Biochemistry
View All
Next
Progressing science for over 60 years
Since our origins in 1947, the LMB has pioneered the molecular biology revolution and is a world-leading source of new ideas, scientific advances and technology. Our discoveries have led to highly successful commercialisations and medical advances that have improved human life.
Explore Our History Timeline
An axon bundle growing from a human brain organoid within a micropatterned device.
Read more about research into axon growth and human brain development
.
Latest Publications
Assembly of two functionally-distinct protein import complexes in the outer membrane of plant chloroplasts.
(20th Apr 2026)
Nellaepalli S, Baretić D, Brandner AF, Kubis-Waller S, Xu D, Soufi Z, Cheng S, Kodru S, Fang J, Flores-Pérez Ú, Ravikumar V, Pulido P, Fournier M, Ahel I, Khalid S, Jarvis RP
Nat Commun
• doi: 10.1038/s41467-026-71676-6
Songbird connectome reveals tunneling of migratory neurons in the adult striatum.
(17th Apr 2026)
Shvedov NR, Castonguay SJ, Rother A, Schick DE, Kornfeld J, Scott BB
Curr Biol
• doi: 10.1016/j.cub.2026.03.057
Gene delivery of immunomodulatory cytokines to the lung preserves respiratory function during inflammatory challenge.
(17th Apr 2026)
Makuyana N, Seldeslachts L, Michiels L, Burton OT, Hernandez AR, Ghodsinia A, Rahman E, Kops LM, Singh K, Naranjo F, Ali M, Dashwood A, Achkir M, Kouser L, Lienart S, Guillaume S, Naesens L, Linterman MA, Wauters J, Joulia R, Humblet-Baron S, Vande Velde G, Dooley J, Liston A
Sci Immunol
• 11(118):eadv7969 • doi: 10.1126/sciimmunol.adv7969
Assembly and phosphoregulatory mechanisms of the budding yeast outer kinetochore KMN complex.
(4th May 2026)
Turner NN, Zhang Z, Yang J, Muir KW, McLaughlin SH, Morgan T, Barford D
J Cell Biol
• 225(5) • doi: 10.1083/jcb.202506015
MitoPerturb-Seq identifies gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy.
Burr SP, Auckland K, Glynos A, Dhawanjewar A, Ryall C, Wei W, Hynes-Allen A, Prater M, Sczaniecka-Clift M, Prudent J, Chinnery PF, van den Ameele J
Nat Struct Mol Biol
• 33(4):711-723 • doi: 10.1038/s41594-026-01779-7
MDA5 generates compact ribonucleoprotein complexes via ATP-dependent double-stranded RNA unwinding.
(19th Mar 2026)
Quack S, Maity S, America PPB, Klein M, Herrero Del Valle A, Singh R, Joiner JD, Rashid ZM, Smitskamp Q, Rivas P, Papini FS, Broedersz CP, Roos WH, Modis Y, Dulin D
Nucleic Acids Res
• 54(6) • doi: 10.1093/nar/gkag274
Electrophysiological development and functional plasticity in dissociated human cerebral organoids across multiple cell lines.
(20th Apr 2026)
Pavlinek A, Guerrisi S, O'Driscoll K, Polit LD, Nagy R, Lancaster MA, Vernon AC, Srivastava DP
Cell Rep Methods
• 6(4):101371 • doi: 10.1016/j.crmeth.2026.101371
Adhesion G protein-coupled receptors.
(16th Jan 2026)
Langenhan T, Anderson GR, Araç D, Aust G, Avila-Zozaya M, Bagger SM, Barth P, Berndt S, Blacklow SC, Blanco-Redondo B, Boucard AA, Bridges JP, Brodmerkel LS, Caron KM, Chung YK, Dates AN, de Araujo Farias V, Del Toro D, Duman JG, Engel FB, Favara DM, Formstone CJ, Fu C, Garcia De Las Bayonas A, Georgiadi A, Gloriam DE, Hall RA, Hamann J, Hildebrand PW, Hsiao CC, Huang BX, Javitch JA, Kim HY, Kittel RJ, Kleinau G, Leduc R, Liebscher I, Lin HH, Linnert J, Ludwig MG, Martinelli DC, Mathiasen S, Matúš D, Melkumyan M, Moreno-Salinas AL, Mulder J, Nash MA, Pal K, Pederick DT, Perry-Hauser NA, Piao X, Ping YQ, Placantonakis DG, Pohl F, Prömel S, Rosenkilde MM, Sabbagh L, Sando RC, Scheerer P, Schöneberg T, Seiradake E, Selcho M, Seufert F, Singh AK, Skiniotis G, Spiess K, Sträter N, Strutt D, Südhof TC, Sun J, Tall GG, Thor D, Tilley DG, Tolias KF, Vallon M, Van Meir EG, Vanhollebeke B, Wiggin GR, Wolfrum U, Yan J, Zaidman NA, Zou Y, Scholz N
Pharmacol Rev
• 78(3):100116 • doi: 10.1016/j.pharmr.2026.100116
Search Published Research
Loading...