Epigenetics & RNA Biology Laboratory | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/erbl
Archived: 2026-04-23 17:11
Epigenetics & RNA Biology Laboratory | National Institute of Environmental Health Sciences
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Epigenetics & RNA Biology Laboratory
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Paul A. Wade, Ph.D.
Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-4133
Fax 919-541-0146
[email protected]
Traci M. Hall, Ph.D.
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-3556
Fax 301-480-3055
[email protected]
Research Summary
The Epigenetics and RNA Biology Laboratory investigates fundamental mechanisms by which epigenetics — non-genetic modulation and alterations — influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches.
Shared and Core Facilities
For more information about facilities that support research activities at the NIEHS campus, please see
Shared and Core Facilities
.
In addition to the cutting edge hypothesis driven research of its investigators the laboratory provides leadership and support to the NIEHS in areas of genomics, epigenomics, mass spectrometry, and bioinformatics analyses. These endeavors build and research strengths established in the prior Laboratory of Molecular Carcinogenesis and extend the scope of the research beyond cancer to examine a broad range of environmental impacts on human health and development.
Principal Investigators
Chromatin & Gene Expression
Trevor K. Archer, Ph.D.
Deputy Director, NIEHS;
NIH Distinguished Investigator
Tel 984-287-4000
Fax 919-316-4566
[email protected]
Eukaryotic Transcriptional Regulation
Paul A. Wade, Ph.D.
Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-4133
Fax 919-541-0146
[email protected]
Macromolecular Structure
Traci M. Hall, Ph.D.
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-3556
Fax 301-480-3055
[email protected]
Molecular & Genetic Epidemiology
Jack A. Taylor, M.D., Ph.D. (Retired)
Scientist Emeritus
Tel 984-287-3684
[email protected]
Single Cell Dynamics
Joseph Rodriguez, Ph.D.
Principal Investigator
Tel 984-287-3104
[email protected]
Stem Cell Biology
Guang Hu, Ph.D.
Senior Investigator
Tel 984-287-4144
[email protected]
Systems Biology
Raja Jothi, Ph.D.
Senior Investigator
Tel 984-287-3696
[email protected]
Transcriptional Responses in Disease
Jason A. Watts, M.D., Ph.D.
Stadtman Investigator
Tel 984-287-4528
Fax 301-480-5525
[email protected]
Scientific Support Staff
Donald L. Cox Jr
Administrative Specialist
Tel 984-287-4005
[email protected]
Derrick L. Raynor
Administrative Technician
Tel 984-287-4006
[email protected]
Publications
Recent Publications
Zhou H, Zhai X, Zhou C, Chen J, Wang X, Li L, Shi W, Sun S, Chen G, Hu G, Zuo E, Zhang M. Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state.
Cell research
.
2026 May;36(5):381-384.
[
Abstract
Zhou H, Zhai X, Zhou C, Chen J, Wang X, Li L, Shi W, Sun S, Chen G, Hu G, Zuo E, Zhang M. Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state. Cell research. 2026 May
]
Stevens D, Hinton K, O'Brien K, Buckley J, Welch B, Watts J, Calafat A, Botelho J, Sinkovskaya E, Przybylska A, Saade G, Abuhamad A, Ferguson K. Considerations for the Analysis of Urinary Environmental Chemical Concentrations During Pregnancy.
Epidemiology (Cambridge, Mass.)
.
2026 May 01;37(3):325-335.
[
Abstract
Stevens D, Hinton K, O'Brien K, Buckley J, Welch B, Watts J, Calafat A, Botelho J, Sinkovskaya E, Przybylska A, Saade G, Abuhamad A, Ferguson K. Considerations for the Analysis of Urinary Environmental Chemical Concentrations During Pregnancy. Epidemiology (Cambridge, Mass.). 2026 May 01
]
Wang D, Wang X, Malki S, Chan Y, Bennett B, Feng J, Tang J, Chen X, McKim D, Zhang C, Tao L, Xu J, Chen Y, Hu G, Ying Q. GSK3α functions as a stemness checkpoint across multiple stem cell states.
Cell research
.
2026 Apr 09 [Epub ahead of print].
[
Abstract
Wang D, Wang X, Malki S, Chan Y, Bennett B, Feng J, Tang J, Chen X, McKim D, Zhang C, Tao L, Xu J, Chen Y, Hu G, Ying Q. GSK3α functions as a stemness checkpoint across multiple stem cell states. Cell research. 2026 Apr 09
]
Yasar P, Day C, Bennett B, Hoffman J, Kammel L, Archer T, Rodriguez J. Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells.
bioRxiv : the preprint server for biology
.
2026 Mar 23 [Epub ahead of print].
[
Abstract
Yasar P, Day C, Bennett B, Hoffman J, Kammel L, Archer T, Rodriguez J. Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells. bioRxiv : the preprint server for biology. 2026 Mar 23
]
Diaz-Jimenez D, Oakley R, Hoffman J, Bortner C, Lih F, Li J, Williams J, Scappini E, Gerrish K, Garantziotis S, Archer T, Cidlowski J. Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
.
2026 Feb 15;40(3):e71510.
[
Abstract
Diaz-Jimenez D, Oakley R, Hoffman J, Bortner C, Lih F, Li J, Williams J, Scappini E, Gerrish K, Garantziotis S, Archer T, Cidlowski J. Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2026 Feb 15
]
More Recent Publications from PubMed
Back
to Top
Last Reviewed: April 22, 2026
Skip Navigation
Epigenetics & RNA Biology Laboratory
Close the left navigation
Add
Paul A. Wade, Ph.D.
Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-4133
Fax 919-541-0146
[email protected]
Traci M. Hall, Ph.D.
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-3556
Fax 301-480-3055
[email protected]
Research Summary
The Epigenetics and RNA Biology Laboratory investigates fundamental mechanisms by which epigenetics — non-genetic modulation and alterations — influences chromatin architecture, transcription and gene expression in normal, cancer and embryonic stem cells and provides insights into biological processes that modulate the effects of environmental exposures. It also focuses on the molecular basis of self-renewal and pluripotency in embryonic stem (ES) cells and induced pluripotency stem (iPS) cells, as well as gene regulatory pathways using genomic, molecular, biochemical, computational and structural approaches.
Shared and Core Facilities
For more information about facilities that support research activities at the NIEHS campus, please see
Shared and Core Facilities
.
In addition to the cutting edge hypothesis driven research of its investigators the laboratory provides leadership and support to the NIEHS in areas of genomics, epigenomics, mass spectrometry, and bioinformatics analyses. These endeavors build and research strengths established in the prior Laboratory of Molecular Carcinogenesis and extend the scope of the research beyond cancer to examine a broad range of environmental impacts on human health and development.
Principal Investigators
Chromatin & Gene Expression
Trevor K. Archer, Ph.D.
Deputy Director, NIEHS;
NIH Distinguished Investigator
Tel 984-287-4000
Fax 919-316-4566
[email protected]
Eukaryotic Transcriptional Regulation
Paul A. Wade, Ph.D.
Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-4133
Fax 919-541-0146
[email protected]
Macromolecular Structure
Traci M. Hall, Ph.D.
Deputy Chief, Epigenetics & RNA Biology Laboratory and Principal Investigator
Tel 984-287-3556
Fax 301-480-3055
[email protected]
Molecular & Genetic Epidemiology
Jack A. Taylor, M.D., Ph.D. (Retired)
Scientist Emeritus
Tel 984-287-3684
[email protected]
Single Cell Dynamics
Joseph Rodriguez, Ph.D.
Principal Investigator
Tel 984-287-3104
[email protected]
Stem Cell Biology
Guang Hu, Ph.D.
Senior Investigator
Tel 984-287-4144
[email protected]
Systems Biology
Raja Jothi, Ph.D.
Senior Investigator
Tel 984-287-3696
[email protected]
Transcriptional Responses in Disease
Jason A. Watts, M.D., Ph.D.
Stadtman Investigator
Tel 984-287-4528
Fax 301-480-5525
[email protected]
Scientific Support Staff
Donald L. Cox Jr
Administrative Specialist
Tel 984-287-4005
[email protected]
Derrick L. Raynor
Administrative Technician
Tel 984-287-4006
[email protected]
Publications
Recent Publications
Zhou H, Zhai X, Zhou C, Chen J, Wang X, Li L, Shi W, Sun S, Chen G, Hu G, Zuo E, Zhang M. Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state.
Cell research
.
2026 May;36(5):381-384.
[
Abstract
Zhou H, Zhai X, Zhou C, Chen J, Wang X, Li L, Shi W, Sun S, Chen G, Hu G, Zuo E, Zhang M. Chemical reprogramming directly resets mouse post-implantation epiblast cells to a totipotent state. Cell research. 2026 May
]
Stevens D, Hinton K, O'Brien K, Buckley J, Welch B, Watts J, Calafat A, Botelho J, Sinkovskaya E, Przybylska A, Saade G, Abuhamad A, Ferguson K. Considerations for the Analysis of Urinary Environmental Chemical Concentrations During Pregnancy.
Epidemiology (Cambridge, Mass.)
.
2026 May 01;37(3):325-335.
[
Abstract
Stevens D, Hinton K, O'Brien K, Buckley J, Welch B, Watts J, Calafat A, Botelho J, Sinkovskaya E, Przybylska A, Saade G, Abuhamad A, Ferguson K. Considerations for the Analysis of Urinary Environmental Chemical Concentrations During Pregnancy. Epidemiology (Cambridge, Mass.). 2026 May 01
]
Wang D, Wang X, Malki S, Chan Y, Bennett B, Feng J, Tang J, Chen X, McKim D, Zhang C, Tao L, Xu J, Chen Y, Hu G, Ying Q. GSK3α functions as a stemness checkpoint across multiple stem cell states.
Cell research
.
2026 Apr 09 [Epub ahead of print].
[
Abstract
Wang D, Wang X, Malki S, Chan Y, Bennett B, Feng J, Tang J, Chen X, McKim D, Zhang C, Tao L, Xu J, Chen Y, Hu G, Ying Q. GSK3α functions as a stemness checkpoint across multiple stem cell states. Cell research. 2026 Apr 09
]
Yasar P, Day C, Bennett B, Hoffman J, Kammel L, Archer T, Rodriguez J. Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells.
bioRxiv : the preprint server for biology
.
2026 Mar 23 [Epub ahead of print].
[
Abstract
Yasar P, Day C, Bennett B, Hoffman J, Kammel L, Archer T, Rodriguez J. Layered Single-Cell Heterogeneity in Hormone Receptor Signaling Across Mouse Organoids and Human ERα+ Cancer Cells. bioRxiv : the preprint server for biology. 2026 Mar 23
]
Diaz-Jimenez D, Oakley R, Hoffman J, Bortner C, Lih F, Li J, Williams J, Scappini E, Gerrish K, Garantziotis S, Archer T, Cidlowski J. Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
.
2026 Feb 15;40(3):e71510.
[
Abstract
Diaz-Jimenez D, Oakley R, Hoffman J, Bortner C, Lih F, Li J, Williams J, Scappini E, Gerrish K, Garantziotis S, Archer T, Cidlowski J. Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2026 Feb 15
]
More Recent Publications from PubMed
Back
to Top
Last Reviewed: April 22, 2026