TRlad Multi-Maker | National Institute of Environmental Health Sciences Skip Navigation TRlad Multi-Maker Close the left navigation Add The TRIad Multi-Marker (TRIMM) program performs max_Z2, and sum_log(P) tests, association tests for a child's or mother's genetic effects using multiple markers from triad families. Statistical significance is evaluated via permutation. It also outputs the nominated risk-haplotype-tagging alleles. For details, see Shi M Umbach DM Weinberg CR "Identification of Risk-related Haplotypes Using Multiple SNPs from Nuclear Families". trimm.zip (27KB) is the ZIPPED set of the following 5 files: R source code: TRIMM.r Program documentation: TRIMM_Documentation.pdf 3 Example files: geno.m geno.f geno.c Contact Min Shi, M.D., Ph.D. Staff Scientist Tel 984-287-3720 [email protected] David M. Umbach, Ph.D. Staff Scientist Tel 984-287-3703 [email protected] Clarice R. Weinberg, Ph.D. Principal Investigator Tel 984-287-3697 [email protected] Back to Top Last Reviewed: December 31, 2025