Cynthia Rider, Ph.D. | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/stb/staff/rider
Archived: 2026-04-23 17:13
Cynthia Rider, Ph.D. | National Institute of Environmental Health Sciences
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Cynthia Rider, Ph.D.
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Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Systems Toxicology Branch
Cynthia V. Rider, Ph.D.
Chief, Systems Toxicology Branch
Tel 984-287-3175
[email protected]
Cynthia Rider, Ph.D., is Chief of the Systems Toxicology Branch (STB) of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences (NIEHS). In this role, she supports STB staff in generating, evaluating, and reporting high quality toxicology data for use in public health decision making.
As a study scientist, she designs and evaluates results from toxicological studies of chemicals selected for investigation by the DTT. She is particularly interested in developing and refining methods for evaluating the toxicity of mixtures to inform risk assessment. Currently, she is the project leader for polycyclic aromatic compounds, which are being used as a case study to evaluate the joint action of chemicals with component-based approaches (e.g., dose addition models). She is also leading an effort to inform the safety evaluation of complex mixtures. Toward this goal, she is using botanical dietary supplements, such as
Ginkgo biloba
extract, to develop methods for determining sufficient similarity of complex mixtures.
Rider received her B.S. from Tulane University, New Orleans, LA in Environmental Studies and Biology and her Ph.D. from North Carolina State University, Raleigh, NC in Environmental Toxicology. She completed post doctoral training in the Reproductive Toxicology Branch of the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency and the Nicholas School of the Environment at Duke University. She joined the DTT in 2010.
Recent Publications
Eccles K, Gaston K, Green E, Waidyanatha S, Stiffler B, Harris S, Rider C, Medlock Kakaley E. Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents.
Environmental science & technology
.
2026 Feb 03;60(4):2976-2987.
[
Abstract
Eccles K, Gaston K, Green E, Waidyanatha S, Stiffler B, Harris S, Rider C, Medlock Kakaley E. Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents. Environmental science & technology. 2026 Feb 03
]
Johnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice.
Frontiers in toxicology
.
2025;7:1558639.
[
Abstract
Johnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice. Frontiers in toxicology. 2025
]
Payton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research.
Frontiers in toxicology
.
2025;7:1535098.
[
Abstract
Payton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research. Frontiers in toxicology. 2025
]
Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system.
Toxicological sciences : an official journal of the Society of Toxicology
.
2025 May 01;205(1):191-204.
[
Abstract
Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system. Toxicological sciences : an official journal of the Society of Toxicology. 2025 May 01
]
Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets.
Environmental and molecular mutagenesis
.
2025 Mar;66(3):99-121.
[
Abstract
Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar
]
NTP Reports
National Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice.
Toxicity report series
.
2016 May [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice. Toxicity report series. 2016 May
]
More Recent Publications from PubMed
Related Links
Innovative research into cancer, mixtures headlines DNTP board meeting
- Environmental Factor, March 2021
Back
to Top
Last Reviewed: March 19, 2026
Skip Navigation
Cynthia Rider, Ph.D.
Close the left navigation
Add
Much of the work carried out by DTT is in support of the National Toxicology Program (NTP), an interagency partnership of the Food and Drug Administration, National Institute for Occupational Safety and Health, and NIEHS.
Visit the NTP Website
Systems Toxicology Branch
Cynthia V. Rider, Ph.D.
Chief, Systems Toxicology Branch
Tel 984-287-3175
[email protected]
Cynthia Rider, Ph.D., is Chief of the Systems Toxicology Branch (STB) of the Division of Translational Toxicology (DTT) at the National Institute of Environmental Health Sciences (NIEHS). In this role, she supports STB staff in generating, evaluating, and reporting high quality toxicology data for use in public health decision making.
As a study scientist, she designs and evaluates results from toxicological studies of chemicals selected for investigation by the DTT. She is particularly interested in developing and refining methods for evaluating the toxicity of mixtures to inform risk assessment. Currently, she is the project leader for polycyclic aromatic compounds, which are being used as a case study to evaluate the joint action of chemicals with component-based approaches (e.g., dose addition models). She is also leading an effort to inform the safety evaluation of complex mixtures. Toward this goal, she is using botanical dietary supplements, such as
Ginkgo biloba
extract, to develop methods for determining sufficient similarity of complex mixtures.
Rider received her B.S. from Tulane University, New Orleans, LA in Environmental Studies and Biology and her Ph.D. from North Carolina State University, Raleigh, NC in Environmental Toxicology. She completed post doctoral training in the Reproductive Toxicology Branch of the National Health and Environmental Effects Research Laboratory, U. S. Environmental Protection Agency and the Nicholas School of the Environment at Duke University. She joined the DTT in 2010.
Recent Publications
Eccles K, Gaston K, Green E, Waidyanatha S, Stiffler B, Harris S, Rider C, Medlock Kakaley E. Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents.
Environmental science & technology
.
2026 Feb 03;60(4):2976-2987.
[
Abstract
Eccles K, Gaston K, Green E, Waidyanatha S, Stiffler B, Harris S, Rider C, Medlock Kakaley E. Challenging Additivity: Comparing Predicted and Observed AhR Activity of Polycyclic Aromatic Compound (PAC) Mixtures Containing Active and Inactive Constituents. Environmental science & technology. 2026 Feb 03
]
Johnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice.
Frontiers in toxicology
.
2025;7:1558639.
[
Abstract
Johnson V, Rider C, Luster M, Willson C, Harris S, Stiffler B, Blake J, Mutlu E, Godfrey V, Burback B, Fernando R, Waidyanatha S, Burleson G, Germolec D. Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice. Frontiers in toxicology. 2025
]
Payton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research.
Frontiers in toxicology
.
2025;7:1535098.
[
Abstract
Payton A, Hickman E, Chappel J, Roell K, Koval L, Eaves L, Chou C, Spring A, Miller S, Avenbuan O, Boyles R, Kruse P, Rider C, Patlewicz G, Ring C, Ward-Caviness C, Reif D, Jaspers I, Fry R, Rager J. TAME 2.0: expanding and improving online data science training for environmental health research. Frontiers in toxicology. 2025
]
Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system.
Toxicological sciences : an official journal of the Society of Toxicology
.
2025 May 01;205(1):191-204.
[
Abstract
Parham F, Eccles K, Rider C, Sakamuru S, Xia M, Huang R, Tice R, Dinse G, DeVito M. Lessons learned from evaluating defined chemical mixtures in a high-throughput estrogen receptor assay system. Toxicological sciences : an official journal of the Society of Toxicology. 2025 May 01
]
Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets.
Environmental and molecular mutagenesis
.
2025 Mar;66(3):99-121.
[
Abstract
Carberry C, Hartwell H, Rider C, Wheeler M, Auerbach S, Rager J. Extracellular Vesicle (EV) Mechanisms of Toxicity for Per and Polyfluoroalkyl Substances: Comparing Transcriptomic Points of Departure Across Global Versus EV Regulatory Gene Sets. Environmental and molecular mutagenesis. 2025 Mar
]
NTP Reports
National Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice.
Toxicity report series
.
2016 May [Epub ahead of print].
[
Abstract
National Toxicology Program. Toxicity studies of α-pinene administered by inhalation to F344/N rats and B6C3F1/N mice. Toxicity report series. 2016 May
]
More Recent Publications from PubMed
Related Links
Innovative research into cancer, mixtures headlines DNTP board meeting
- Environmental Factor, March 2021
Back
to Top
Last Reviewed: March 19, 2026