Shimadzu Core Laboratory

Shimadzu Core Laboratory
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Shimadzu Core Laboratory for Academic and Research Excellence
The Shimadzu Core Laboratory is a multidisciplinary science research center containing
over 2000 square feet of presentation, research, and collaboration space housed in
the College of Arts, Sciences and Education. The instruments installed in the lab
are a combination of highly sensitive and accurate spectroscopic and spectrometric
instruments used for characterizing and measuring compounds in a variety of sample
types. The laboratory has a MALDI-TOF Mass Spectrometer which can be used to characterize
proteins, polymers, and image tissues for different compounds. One of the instruments
in the lab which will be in constant use is a gas chromatography mass spectrometer
which can be used to identify and quantify compounds in samples ranging from contaminants
in the local water system to compounds being bioengineered by the faculty in the College
of Pharmacy.
The laboratory also has advanced liquid chromatography capabilities with a triple
quadrupole mass spectrometer (LC-MS/MS). This instrument has the capability to carry
out experiments for a variety of faculty doing everything from pharmacokinetics to
forensic analysis. Some other instruments in the lab include UV-vis spectrometers,
FT-IR spectrometer and other preparatory chromatography systems.
Educational Space
This formal instructional space occupies approximately one third of the SCL laboratory.
It is fully equipped with A/V equipment, a computer and tables and chairs. It is well-suited
for class lectures on instrumentation techniques as well as community education projects.
Services Offered
Sample Analysis
Course Module Development and Implementation Planning
Experimental Design Consultations
Laboratory Instruments
The Shimadzu Core Laboratory facility is supported by a $500,000 in-kind grant from
Shimadzu, a Japanese maker of precision instruments, including high-sensitivity spectroscopic
and spectrometric equipment. This facility provides faculty and students with access
to state of the art instrumentation that rivals research-intensive institutions. Click
here for more information on available lab instrumentation:
Pictures and Descriptions of Laboratory Instruments
Lab Policies and Procedures
Core Lab User Policy and Procedure:
This document is intended to provide users of the Shimadzu Core Lab (SCL) with detailed
information about the use of this facility. As a campus-wide resource, the SCL provides
specialized equipment and services not routinely available in individual laboratories.
The lab has limited staffing available for provide training and technical assistance
for the operation of equipment available in the lab. This document provides general
expectations for core lab users, including the policies that govern the operation
and use of the lab. Faculty, students, and staff who use the lab will be expected
to read and observe the following operating procedures. Continued access to these
resources will be contingent upon appropriate interaction with staff, and responsible
use of all equipment as well as payment of charges incurred if applicable.
NMR Standard Operating Procedure "Basic Operations for the Bruker 500 MHz NMR"
: This written SOP is designed to provide a standard operation procedure for approved
faculty, staff, student, and student employees to operate the NMR in the Core Laboratory.
This SOP addresses only the basic operations of the NMR and does not address any NMR
maintenance including the use of cryogens, spectrometer modifications repair or emergency
procedures.
Recent Lab Publications
McNair J, Lane M, Hart J, Porter A, Briggs S, Southwell B, Sivy T, Szlag D, Scull
B, Pike S, Dreelin E, Verier C, Carter B, Sharp J, Nowlin P, Rediske R. Validity assessment
of Michigan's proposed qPCR threshold value for rapid water-quality monitoring of
E. Coli contamination.
Water Research
2022; 226:119235.
Validity assessment of Michigan's proposed qPCR threshold value for rapid water-quality
monitoring of E. coli contamination
Shultz C, Swanson MA, Dowling TC, Bachmann AS. Probenecid increases renal retention
and antitumor activity of DFMO in neuroblastoma.
Cancer Chemother Pharmacol
2021;8:607-617.
Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
VonSeggern M, Szarowicz C, Swanson M, Cavotta S, Pike S, Lamberts J. Purine molecules
in Parkinson's disease: Analytical techniques and clinical implications.
Neurochem Int
2020; 139: 104793.
Purine molecules in Parkinson's disease: Analytical techniques and clinical implications
Lane M, Rediske R, McNair J, Briggs S, Rhodes G, Dreelin E, Sivy T, Flood M, Szlag
D, Southwell B, Isaacs N, Pike S. A comparison of E. Coli concentration estimates
quantified by the EPA and Michigan laboratory network using EPA Draft Method C.
J Microb Methods
2020; 170: 106086.
A comparison of E. coli concentration estimates quantified by the EPA and a Michigan
laboratory network using EPA Draft Method C
Nybo SE, Saunders J, McCormick SP. Metabolic engineering of
Escherichia coli
for production of valerenadiene.
J Biotechnology
2017;262:60-66.
Metabolic engineering of Escherichia coli for production of valerenadiene
Medina-Moreno S, Dowling TC, Zapata JC, Le NM, Sausville E, Bryant J, Redfield RR,
Heredia A. Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces
HIV viremia in chronically infected humanized mice.
PLoS ONE
2017; 12(8):e0183425.
Targeting of CDK9 with indirubin 3’-monoxime safely and durably reduces HIV viremia
in chronically infected humanized mice
Contact
Dr. Schuyler (Sky) Pike
Director, Shimadzu Core Lab
[email protected]
Ferris State University
College of Arts, Sciences and Education
820 Campus Drive
ASC 0010
(231) 591-3670
Contact
Office of Research & Sponsored Programs
Ferris Library for Information, Technology and Education (FLITE)
Ferris State University
1010 Campus Drive, FLITE 410 D & F
Big Rapids, MI 49307
(231) 591-2547
[email protected]
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