Nuclear Magnetic Resonance Group | National Institute of Environmental Health Sciences
Source: https://www.niehs.nih.gov/research/atniehs/labs/gisbl/nmr
Archived: 2026-04-23 17:14
Nuclear Magnetic Resonance Group | National Institute of Environmental Health Sciences
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Nuclear Magnetic Resonance Group
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NMR & Ligand-Macromolecule Interactions
Geoffrey A. Mueller, Ph.D.
Director, Nuclear Magnetic Resonance Research Core Facility and Principal Investigator
Tel 984-287-3589
Fax 919-541-5707
[email protected]
DNA Polymerase Beta
DNA Repair Complexes
HIV-RT monomer
HIV Reverse Transcriptase
Cockroach allergen Bla g 1
Allergic Diseases and Allergens
Research Summary
Geoffrey Mueller, Ph.D., leads the Nuclear Magnetic Resonance Group and serves as Director of the NIEHS NMR Research Core Facility. Mueller does independent research on the molecular determinants of allergic disease. Primarily, the research is focused on allergens, which stimulate the symptoms of allergic disease. The goals of the research are:
To better understand why certain proteins are allergens
To improve allergen exposure measurements
To search for predictive components of allergy therapy
To better diagnosis cross-reactivity among allergens
To design novel immunotherapeutics
The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern. As part of the Genome Integrity and Structural Biology Laboratory, our primary focus has been the evaluation of structural, conformational and dynamic responses of proteins to substrates, cofactors, allosteric effectors, other proteins, putative environmental toxins, nucleic acids, etc. In addition, we are interested in various aspects of allergic disease including the characterization of allergens and metabolomic analyses of pollens.
Major areas of research:
DNA repair complexes
HIV reverse transcriptase
Allergic Disease and Allergens
Current projects:
Structural and dynamic characterization of enzymes involved in DNA polymerization
Nuclear localization signals of DNA repair enzymes
Accessory proteins in DNA repair
Studies or HIV reverse transcriptase
Characterization of Allergens
Metabolomic analyses of pollens
Mueller received his Ph.D. in biophysics from the University of Virginia in 1998. He trained as a postdoctoral fellow with Lewis Kay, Ph.D., and Julie Forman-Kay, Ph.D., at the University of Toronto until 2001, researching the application of Nuclear Magnetic Resonance (NMR). London recruited Mueller to join the NMR group as a Staff Scientist. In 2020, Mueller became the Director of the NMR Research Core Facility and head of the Nuclear Magnetic Resonance Group.
Video
Related Links
Why Immunotherapy for Peanut Allergy Works for Some, Not Everyone
- Environmental Factor, February 2023
NIEHS Scientist Reshaping Future of Allergy Treatments
- Environmental Factor, June 2022
Insect study may lead to treatments for life-threatening viruses
- Environmental Factor, April 2021
Back
to Top
Last Reviewed: April 10, 2026
Skip Navigation
Nuclear Magnetic Resonance Group
Close the left navigation
Add
NMR & Ligand-Macromolecule Interactions
Geoffrey A. Mueller, Ph.D.
Director, Nuclear Magnetic Resonance Research Core Facility and Principal Investigator
Tel 984-287-3589
Fax 919-541-5707
[email protected]
DNA Polymerase Beta
DNA Repair Complexes
HIV-RT monomer
HIV Reverse Transcriptase
Cockroach allergen Bla g 1
Allergic Diseases and Allergens
Research Summary
Geoffrey Mueller, Ph.D., leads the Nuclear Magnetic Resonance Group and serves as Director of the NIEHS NMR Research Core Facility. Mueller does independent research on the molecular determinants of allergic disease. Primarily, the research is focused on allergens, which stimulate the symptoms of allergic disease. The goals of the research are:
To better understand why certain proteins are allergens
To improve allergen exposure measurements
To search for predictive components of allergy therapy
To better diagnosis cross-reactivity among allergens
To design novel immunotherapeutics
The Nuclear Magnetic Resonance (NMR) Group performs fundamental research on biological systems aimed at providing insight into the molecular mechanisms that underlie problems of environmental concern. As part of the Genome Integrity and Structural Biology Laboratory, our primary focus has been the evaluation of structural, conformational and dynamic responses of proteins to substrates, cofactors, allosteric effectors, other proteins, putative environmental toxins, nucleic acids, etc. In addition, we are interested in various aspects of allergic disease including the characterization of allergens and metabolomic analyses of pollens.
Major areas of research:
DNA repair complexes
HIV reverse transcriptase
Allergic Disease and Allergens
Current projects:
Structural and dynamic characterization of enzymes involved in DNA polymerization
Nuclear localization signals of DNA repair enzymes
Accessory proteins in DNA repair
Studies or HIV reverse transcriptase
Characterization of Allergens
Metabolomic analyses of pollens
Mueller received his Ph.D. in biophysics from the University of Virginia in 1998. He trained as a postdoctoral fellow with Lewis Kay, Ph.D., and Julie Forman-Kay, Ph.D., at the University of Toronto until 2001, researching the application of Nuclear Magnetic Resonance (NMR). London recruited Mueller to join the NMR group as a Staff Scientist. In 2020, Mueller became the Director of the NMR Research Core Facility and head of the Nuclear Magnetic Resonance Group.
Video
Related Links
Why Immunotherapy for Peanut Allergy Works for Some, Not Everyone
- Environmental Factor, February 2023
NIEHS Scientist Reshaping Future of Allergy Treatments
- Environmental Factor, June 2022
Insect study may lead to treatments for life-threatening viruses
- Environmental Factor, April 2021
Back
to Top
Last Reviewed: April 10, 2026