Recommended Reading | National Institute of Environmental Health Sciences
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Archived: 2026-04-23 17:15
Recommended Reading | National Institute of Environmental Health Sciences
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Recommended Reading
Environmental Health Language Collaborative
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Recommended Reading
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Speaking the Same Language
Environmental Health Use Cases
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Concluded Use Case Working Groups
Data Discovery Use Case
Data Harmonization Use Case
The select publications below offer background and further insights regarding the value of
speaking the same language
in environmental health sciences research.
Adverse Outcome Pathways and Aggregate Exposure Pathways
Mortensen H, Hench V, Nymark P et al. The Environmental Health Language Collaborative (EHLC) Adverse Outcome Pathway (AOP) Standards Workshop Report [version 1; peer review: not peer reviewed]. F1000Research 2026, 15:323.
[
Abstract
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849.
]
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849. [
Abstract
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849.
]
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci. 142(2): 312-320. [
Abstract
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci. 142(2): 312-320.
]
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway development II: best practices. Toxicol Sci. 142(2): 321-330. [
Abstract
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway development II: best practices. Toxicol Sci. 142(2): 321-330.
]
Environmental Epidemiology
Brook JR, Doiron D, Setton E, Lakerveld J. 2021. Centralizing environmental datasets to support (inter)national chronic disease research: Values, challenges, and recommendations. Environ Epidemiol. 5(1):e129. [
Abstract
Brook JR, Doiron D, Setton E, Lakerveld J. 2021. Centralizing environmental datasets to support (inter)national chronic disease research: Values, challenges, and recommendations. Environ Epidemiol. 5(1):e129.
]
Burns CJ, Lakind JS, Mattison DR, Alcala CS, Branch F, Castillo J, Clark A, Clougherty JE, Darney SP, Erickson H, Goodman M, Greiner M, Jurek AM, Miller A, Rooney AA, Zidek A. 2019. A matrix for bridging the epidemiology and risk assessment gap. Global Epidemiology. 1: 100005 [
Abstract
Burns CJ, Lakind JS, Mattison DR, Alcala CS, Branch F, Castillo J, Clark A, Clougherty JE, Darney SP, Erickson H, Goodman M, Greiner M, Jurek AM, Miller A, Rooney AA, Zidek A. 2019. A matrix for bridging the epidemiology and risk assessment gap. Global Epidemiology. 1: 100005
]
Exposome
Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF. 2017. From the exposome to mechanistic understanding of chemical-induced adverse effects. Environ Int. 99:97-106. [
Abstract
Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF. 2017. From the exposome to mechanistic understanding of chemical-induced adverse effects. Environ Int. 99:97-106.
]
Manrai AK, Cui Y, Bushel PR, et al. 2017. Informatics and data analytics to support exposome-based discovery for public health. Annual Review of Public Health. 20(38): 279-294. [
Abstract
Manrai AK, Cui Y, Bushel PR, et al. 2017. Informatics and data analytics to support exposome-based discovery for public health. Annual Review of Public Health. 20(38): 279-294.
]
Integrative Platforms
Davis AP, Grondin CJ, Johnson RJ, et al. 2021. Comparative Toxicogenomics Database (CTD): Update 2021. Nucleic Acids Research. 49(D1): D1138-D1143. [
Abstract
Davis AP, Grondin CJ, Johnson RJ, et al. 2021. Comparative Toxicogenomics Database (CTD): Update 2021. Nucleic Acids Research. 49(D1): D1138-D1143.
]
Mungall CJ, McMurry JA, Köhler S, et al. 2017. The Monarch Initiative: An integrative data and analytic platform connecting phenotypes to genotypes across species. Nucleic Acids Research. 45(D1): D712-D722. [
Abstract
Mungall CJ, McMurry JA, Köhler S, et al. 2017. The Monarch Initiative: An integrative data and analytic platform connecting phenotypes to genotypes across species. Nucleic Acids Research. 45(D1): D712-D722.
]
Ontologies
Whaley P, Edwards SW, Kraft A, et al. 2020. Knowledge organization systems for systematic chemical assessments. Environmental Health Perspectives. 128(12): 125001. [
Abstract
Whaley P, Edwards SW, Kraft A, et al. 2020. Knowledge organization systems for systematic chemical assessments. Environmental Health Perspectives. 128(12): 125001.
]
Boyles RR, Thessen AE, and Haendel MA. 2019. Ontology-based data integration for advancing toxicological knowledge. Current Opinion in Toxicology. 16: 67-74. [
Abstract
Boyles RR, Thessen AE, and Haendel MA. 2019. Ontology-based data integration for advancing toxicological knowledge. Current Opinion in Toxicology. 16: 67-74.
]
Price P and Leonard J. 2019. A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways. Current Opinion in Toxicology. 16 (Aug): 58-66. [
Abstract
Price P and Leonard J. 2019. A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways. Current Opinion in Toxicology. 16 (Aug): 58-66.
]
Köhler S, Doelken SC, Mungall CJ, et al. 2014. The Human Phenotype Ontology project: Linking molecular biology and disease through phenotype data. Nucleic Acids Research. 42(D1): D966-D974. [
Abstract
Köhler S, Doelken SC, Mungall CJ, et al. 2014. The Human Phenotype Ontology project: Linking molecular biology and disease through phenotype data. Nucleic Acids Research. 42(D1): D966-D974.
]
Hardy B, Apic G, Carthew P, et al. 2012. A toxicology ontology roadmap. ALTEX. 29(20): 129-37. [
Abstract
Hardy B, Apic G, Carthew P, et al. 2012. A toxicology ontology roadmap. ALTEX. 29(20): 129-37.
]
Mattingly CJ, McKone TE, Callahan MA, et al. 2012. Providing the missing link: The Exposure Science Ontology ExO. Environmental Science & Technology. 46(6): 3046-3053. [
Abstract
Mattingly CJ, McKone TE, Callahan MA, et al. 2012. Providing the missing link: The Exposure Science Ontology ExO. Environmental Science & Technology. 46(6): 3046-3053.
]
Back
to Top
Last Reviewed: February 26, 2026
Skip Navigation
Recommended Reading
Environmental Health Language Collaborative
Close the left navigation
Add
Home
About EHLC
Executive Committee
Events
Get Involved
Resources
Common Language Glossary
Recommended Reading
Recommended Viewing
Speaking the Same Language
Environmental Health Use Cases
Biomarkers and Biological Processes of Exposure Use Case
Concluded Use Case Working Groups
Data Discovery Use Case
Data Harmonization Use Case
The select publications below offer background and further insights regarding the value of
speaking the same language
in environmental health sciences research.
Adverse Outcome Pathways and Aggregate Exposure Pathways
Mortensen H, Hench V, Nymark P et al. The Environmental Health Language Collaborative (EHLC) Adverse Outcome Pathway (AOP) Standards Workshop Report [version 1; peer review: not peer reviewed]. F1000Research 2026, 15:323.
[
Abstract
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849.
]
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849. [
Abstract
Hines DE, Edwards SW, Conolly RB, Jarabek AM. 2018. A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA). Environ Sci Technol. doi: 10.1021/acs.est.7b04940. 52(2): 839-849.
]
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci. 142(2): 312-320. [
Abstract
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway (AOP) development I: strategies and principles. Toxicol Sci. 142(2): 312-320.
]
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway development II: best practices. Toxicol Sci. 142(2): 321-330. [
Abstract
Villeneuve DL, Crump D, Garcia-Reyero N, Hecker M, Hutchinson TH, LaLone CA, Landesmann B, Lettieri T, Munn S, Nepelska M, Ottinger MA, Vergauwen L, Whelan M. 2014. Adverse outcome pathway development II: best practices. Toxicol Sci. 142(2): 321-330.
]
Environmental Epidemiology
Brook JR, Doiron D, Setton E, Lakerveld J. 2021. Centralizing environmental datasets to support (inter)national chronic disease research: Values, challenges, and recommendations. Environ Epidemiol. 5(1):e129. [
Abstract
Brook JR, Doiron D, Setton E, Lakerveld J. 2021. Centralizing environmental datasets to support (inter)national chronic disease research: Values, challenges, and recommendations. Environ Epidemiol. 5(1):e129.
]
Burns CJ, Lakind JS, Mattison DR, Alcala CS, Branch F, Castillo J, Clark A, Clougherty JE, Darney SP, Erickson H, Goodman M, Greiner M, Jurek AM, Miller A, Rooney AA, Zidek A. 2019. A matrix for bridging the epidemiology and risk assessment gap. Global Epidemiology. 1: 100005 [
Abstract
Burns CJ, Lakind JS, Mattison DR, Alcala CS, Branch F, Castillo J, Clark A, Clougherty JE, Darney SP, Erickson H, Goodman M, Greiner M, Jurek AM, Miller A, Rooney AA, Zidek A. 2019. A matrix for bridging the epidemiology and risk assessment gap. Global Epidemiology. 1: 100005
]
Exposome
Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF. 2017. From the exposome to mechanistic understanding of chemical-induced adverse effects. Environ Int. 99:97-106. [
Abstract
Escher BI, Hackermüller J, Polte T, Scholz S, Aigner A, Altenburger R, Böhme A, Bopp SK, Brack W, Busch W, Chadeau-Hyam M, Covaci A, Eisenträger A, Galligan JJ, Garcia-Reyero N, Hartung T, Hein M, Herberth G, Jahnke A, Kleinjans J, Klüver N, Krauss M, Lamoree M, Lehmann I, Luckenbach T, Miller GW, Müller A, Phillips DH, Reemtsma T, Rolle-Kampczyk U, Schüürmann G, Schwikowski B, Tan YM, Trump S, Walter-Rohde S, Wambaugh JF. 2017. From the exposome to mechanistic understanding of chemical-induced adverse effects. Environ Int. 99:97-106.
]
Manrai AK, Cui Y, Bushel PR, et al. 2017. Informatics and data analytics to support exposome-based discovery for public health. Annual Review of Public Health. 20(38): 279-294. [
Abstract
Manrai AK, Cui Y, Bushel PR, et al. 2017. Informatics and data analytics to support exposome-based discovery for public health. Annual Review of Public Health. 20(38): 279-294.
]
Integrative Platforms
Davis AP, Grondin CJ, Johnson RJ, et al. 2021. Comparative Toxicogenomics Database (CTD): Update 2021. Nucleic Acids Research. 49(D1): D1138-D1143. [
Abstract
Davis AP, Grondin CJ, Johnson RJ, et al. 2021. Comparative Toxicogenomics Database (CTD): Update 2021. Nucleic Acids Research. 49(D1): D1138-D1143.
]
Mungall CJ, McMurry JA, Köhler S, et al. 2017. The Monarch Initiative: An integrative data and analytic platform connecting phenotypes to genotypes across species. Nucleic Acids Research. 45(D1): D712-D722. [
Abstract
Mungall CJ, McMurry JA, Köhler S, et al. 2017. The Monarch Initiative: An integrative data and analytic platform connecting phenotypes to genotypes across species. Nucleic Acids Research. 45(D1): D712-D722.
]
Ontologies
Whaley P, Edwards SW, Kraft A, et al. 2020. Knowledge organization systems for systematic chemical assessments. Environmental Health Perspectives. 128(12): 125001. [
Abstract
Whaley P, Edwards SW, Kraft A, et al. 2020. Knowledge organization systems for systematic chemical assessments. Environmental Health Perspectives. 128(12): 125001.
]
Boyles RR, Thessen AE, and Haendel MA. 2019. Ontology-based data integration for advancing toxicological knowledge. Current Opinion in Toxicology. 16: 67-74. [
Abstract
Boyles RR, Thessen AE, and Haendel MA. 2019. Ontology-based data integration for advancing toxicological knowledge. Current Opinion in Toxicology. 16: 67-74.
]
Price P and Leonard J. 2019. A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways. Current Opinion in Toxicology. 16 (Aug): 58-66. [
Abstract
Price P and Leonard J. 2019. A proposal for creating a taxonomy of chemical interactions using concepts from the aggregate exposure and adverse outcome pathways. Current Opinion in Toxicology. 16 (Aug): 58-66.
]
Köhler S, Doelken SC, Mungall CJ, et al. 2014. The Human Phenotype Ontology project: Linking molecular biology and disease through phenotype data. Nucleic Acids Research. 42(D1): D966-D974. [
Abstract
Köhler S, Doelken SC, Mungall CJ, et al. 2014. The Human Phenotype Ontology project: Linking molecular biology and disease through phenotype data. Nucleic Acids Research. 42(D1): D966-D974.
]
Hardy B, Apic G, Carthew P, et al. 2012. A toxicology ontology roadmap. ALTEX. 29(20): 129-37. [
Abstract
Hardy B, Apic G, Carthew P, et al. 2012. A toxicology ontology roadmap. ALTEX. 29(20): 129-37.
]
Mattingly CJ, McKone TE, Callahan MA, et al. 2012. Providing the missing link: The Exposure Science Ontology ExO. Environmental Science & Technology. 46(6): 3046-3053. [
Abstract
Mattingly CJ, McKone TE, Callahan MA, et al. 2012. Providing the missing link: The Exposure Science Ontology ExO. Environmental Science & Technology. 46(6): 3046-3053.
]
Back
to Top
Last Reviewed: February 26, 2026