BRCA2 hypomorphic missense variants confer moderate risks of breast cancer - PMC

¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

²Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

³Genotoxic Stress and Cancer, Institut Curie, Orsay, France

⁴Department of Human Genetics, University of Chicago, Chicago, IL, USA

⁵Research Center, Institute Curie, Orsay, France

⁶Cancer Control and Population Sciences, University of Utah, Salt Lake City, UT, USA

⁷Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA

⁸Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands

⁹Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

¹⁰Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada

¹¹Department of Molecular Genetics, University of Toronto, Toronto, Canada

¹²Department of Epidemiology, University of California Irvine, Irvine, CA, USA

¹³Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

¹⁴Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

¹⁵Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain

¹⁶Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain

¹⁷Department of Radiation Oncology, Hannover Medical School, Hannover, Germany

¹⁸Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

¹⁹Copenhagen General Population Study, Herlevand Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

²⁰Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

²¹Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

²²Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

²³Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway

²⁴K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

²⁵Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany

²⁶University of Tübingen, Tübingen, Germany

²⁷German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany

²⁸International Agency for Research on Cancer, Lyon, France

²⁹Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany

³⁰Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands

³¹Laboratory of Experimental Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium

³²Department of General Medical Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

³³Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany

³⁴Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany

³⁵Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

³⁶Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

³⁷University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

³⁸Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

³⁹Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore

⁴⁰Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

⁴¹Cancer Research Institute, Seoul National University, Seoul, Korea

⁴²Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

⁴³Sheffield Cancer Research, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK

⁴⁴Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK

⁴⁵Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

⁴⁶Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

⁴⁷Department of Oncology, University of Cambridge, Cambridge, UK

⁴⁸David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, USA

⁴⁹Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh, UK

⁵⁰Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA

⁵¹Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

⁵²Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia

⁵³Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia

⁵⁴Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France

⁵⁵Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

⁵⁶Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

⁵⁷Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

⁵⁸Department of Surgery, National University Health System, Singapore, Singapore

⁵⁹Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

⁶⁰Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

⁶¹Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

⁶²Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

⁶³Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

⁶⁴Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland

⁶⁵Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland

⁶⁶Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland

⁶⁷Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway

⁶⁸Cancer Research Initiatives Foundation, Subang Jaya, Selangor, Malaysia

⁶⁹Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia

⁷⁰Vesalius Research Center, Leuven, Belgium

⁷¹Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium

⁷²University of Hawaii Cancer Center, Honolulu, HI, USA

⁷³Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

⁷⁴Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK

⁷⁵Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic

⁷⁶Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden

⁷⁷National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany

⁷⁸Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan

⁷⁹Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

⁸⁰Institute of Population Health, University of Manchester, Manchester, UK

⁸¹Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA

⁸²Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

⁸³Department of Genetics, University of Groningen, Groningen, The Netherlands

⁸⁴IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy

⁸⁵Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland

⁸⁶Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland

⁸⁷Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy

⁸⁸Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

⁸⁹National Cancer Institute, Bangkok, Thailand

⁹⁰Research Oncology, Guy’s Hospital, King's College London, London, UK

⁹¹Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK

⁹²Division of Breast Cancer Research, The Institute of Cancer Research, London, UK

⁹³School of Public Health, China Medical University, Taichung, Taiwan

⁹⁴Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan

⁹⁵Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA

⁹⁶Department of Pathology, The University of Melbourne, Melbourne, Australia

⁹⁷Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK

⁹⁸Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia

⁹⁹Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan

¹⁰⁰Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China

¹⁰¹Westmead Millenium Institute for Medical Research, University of Sydney, Sydney, Australia

¹⁰²Department of Pathology, University of Otago, Christchurch, New Zealand

¹⁰³Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), Athens, Greece

¹⁰⁴Center for Medical Genetics, Ghent University Hospita, Ghent, Belgium

¹⁰⁵Unit of Hereditary Cancers, IRCCS AOU San Martino, Genova, Italy

¹⁰⁶Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia

¹⁰⁷Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

¹⁰⁸Department of Oncologic Science, University of South Florida, Tampa, FL, USA

¹⁰⁹Huntsman Cancer Institute and Department of Dermatology, University of Utah, Salt lake City, UT, USA