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MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis. Genes Dev. 2025 Dec 01; 39(23-24):1451-1467. Muncie-Vasic JM, Sinha T, Clark AP, Brower EF, Saucerman JJ, Black BL, Bruneau BG. PMID: 40883017; PMCID: PMC12412991.
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Lineage Tracing Reveals a Shared Cellular Origin for Supraclavicular Brown and Inguinal Beige Adipocytes. bioRxiv. 2025 Oct 03. Ran Y, Zhang K, Shen YT, Mo Q, Wang Z, Yalamanchili HK, John S, Kogiso M, Gao X, Wang C, Sinha T, Black BL, Chen MH. PMID: 41256459; PMCID: PMC12621668.
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Abstract Thu062: Clonal Fate Mapping of Sinoatrial Node Progenitors. Circulation Research. 2025 Aug 1; 137(Suppl_1). Kethana KK, Galang GG, Chouhan CG, Mandla MR, Sinha ST, Devine DW, Mohan MR, Soe SA, Vedantham VV, Black BB. .
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Abstract NBT202: Heart Tube Morphogenesis Is Regulated By Segment-Specific Gene Regulatory Networks Controlled By MEF2C. Circulation Research. 2025 Aug 1; 137(Suppl_1). Muncie-Vasic MJ, Sinha ST, Clark CA, Brower BE, Saucerman SJ, Black BB, Bruneau BB. .
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MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis. bioRxiv. 2025 Mar 27. Muncie-Vasic JM, Sinha T, Clark AP, Brower EF, Saucerman JJ, Black BL, Bruneau BG. PMID: 39554149; PMCID: PMC11566030.
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Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats. Proc Natl Acad Sci U S A. 2024 Jul 30; 121(31):e2220020121. Celona B, Salomonsson SE, Wu H, Dang B, Kratochvil HT, Clelland CD, DeGrado WF, Black BL. PMID: 39042693; PMCID: PMC11295049.
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An injury-responsive mmp14b enhancer is required for heart regeneration. Sci Adv. 2023 12; 9(48):eadh5313. Zlatanova I, Sun F, Wu RS, Chen X, Lau BH, Colombier P, Sinha T, Celona B, Xu SM, Materna SC, Huang GN, Black BL. PMID: 38019918; PMCID: PMC10686572.
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Correction: Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. Elife. 2023 Aug 08; 12. Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AAB, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Cooper MA, Gambin Y, Francois M. PMID: 37551662; PMCID: PMC10409503.
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ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment. Cell Rep. 2023 06 27; 42(6):112665. Steimle JD, Kim C, Rowton M, Nadadur RD, Wang Z, Stocker M, Hoffmann AD, Hanson E, Kweon J, Sinha T, Choi K, Black BL, Cunningham JM, Moskowitz IP, Ikegami K. PMID: 37330911; PMCID: PMC10592526.
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A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors. Development. 2023 05 01; 150(9). Krup AL, Winchester SAB, Ranade SS, Agrawal A, Devine WP, Sinha T, Choudhary K, Dominguez MH, Thomas R, Black BL, Srivastava D, Bruneau BG. PMID: 36994838; PMCID: PMC10259516.
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TCF7L1 Exacerbates Abdominal Aortic Aneurysm Prevalence and Severity. JACC Basic Transl Sci. 2023 Feb; 8(2):171-173. Khachigian LM, Black BL. PMID: 36908666; PMCID: PMC9999003.
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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair. Cell Stem Cell. 2023 01 05; 30(1):96-111.e6. Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. PMID: 36516837; PMCID: PMC9830588.
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Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor. Sci Transl Med. 2022 09 14; 14(662):eabj8670. Smith GA, Padmanabhan A, Lau BH, Pampana A, Li L, Lee CY, Pelonero A, Nishino T, Sadagopan N, Xia VQ, Jain R, Natarajan P, Wu RS, Black BL, Srivastava D, Shokat KM, Chorba JS. PMID: 36103516; PMCID: PMC10174261.
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Transcription Factor GATA4 Regulates Cell Type-Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitors. Circulation. 2022 09 06; 146(10):770-787. Zhu L, Choudhary K, Gonzalez-Teran B, Ang YS, Thomas R, Stone NR, Liu L, Zhou P, Zhu C, Ruan H, Huang Y, Jin S, Pelonero A, Koback F, Padmanabhan A, Sadagopan N, Hsu A, Costa MW, Gifford CA, van Bemmel JG, Hüttenhain R, Vedantham V, Conklin BR, Black BL, Bruneau BG, Steinmetz L, Krogan NJ, Pollard KS, Srivastava D. PMID: 35938400; PMCID: PMC9452483.
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Transcriptional regulation of vascular smooth muscle cell proliferation, differentiation and senescence: Novel targets for therapy. Vascul Pharmacol. 2022 10; 146:107091. Khachigian LM, Black BL, Ferdinandy P, De Caterina R, Madonna R, Geng YJ. PMID: 35896140.
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Differential Etv2 threshold requirement for endothelial and erythropoietic development. Cell Rep. 2022 05 31; 39(9):110881. Sinha T, Lammerts van Bueren K, Dickel DE, Zlatanova I, Thomas R, Lizama CO, Xu SM, Zovein AC, Ikegami K, Moskowitz IP, Pollard KS, Pennacchio LA, Black BL. PMID: 35649376; PMCID: PMC9203129.
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Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022 03 03; 185(5):794-814.e30. Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D. PMID: 35182466; PMCID: PMC8923057.
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Abstract 11332: Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes. Circulation. 2021 Nov 16; 144(Suppl_1):a11332-a11332. Teran TB, Pittman PM, Thomas TR, Felix FF, Richmond-Buccola RD, Choudhary CK, Moroni ME, Giorgio GC, Padmanabhan PA, Costa CM, Huang HY, Alexanian AM, Lee LC, Cole CB, Samse-Knapp SK, McGregor MM, Gifford GC, Huttenhain HR, Gelb GB, Conklin CB, Black BB, Bruneau BB, Krogan KN, Pollard PK, Srivastava SD. .
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Comprehensive cell type decomposition of circulating cell-free DNA with CelFiE. Nat Commun. 2021 05 11; 12(1):2717. Caggiano C, Celona B, Garton F, Mefford J, Black BL, Henderson R, Lomen-Hoerth C, Dahl A, Zaitlen N. PMID: 33976150; PMCID: PMC8113516.
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Control of ribosomal protein synthesis by the Microprocessor complex. Sci Signal. 2021 02 23; 14(671). Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A. PMID: 33622983; PMCID: PMC8012103.
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Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer. Circ Res. 2020 12 04; 127(12):1522-1535. van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott IC, Christoffels VM. PMID: 33040635; PMCID: PMC8153223.
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ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function. Circ Res. 2020 12 04; 127(12):1502-1518. Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V. PMID: 33044128; PMCID: PMC7720845.
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Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection. Neuron. 2020 07 08; 107(1):95-111.e6. Orr BO, Hauswirth AG, Celona B, Fetter RD, Zunino G, Kvon EZ, Zhu Y, Pennacchio LA, Black BL, Davis GW. PMID: 32380032; PMCID: PMC7529479.
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Estimating the Rate of Cell Type Degeneration from Epigenetic Sequencing of Cell-Free DNA. . 2020 Jan 1; 12074:240-242. Caggiano CC, Celona CB, Garton GF, Mefford MJ, Black BB, Lomen-Hoerth LC, Dahl DA, Zaitlen ZN. .
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Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 12 02; 129(12):5374-5380. Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. PMID: 31513549; PMCID: PMC6877301.
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Noncoding deletions reveal a gene that is critical for intestinal function. Nature. 2019 07; 571(7763):107-111. Oz-Levi D, Olender T, Bar-Joseph I, Zhu Y, Marek-Yagel D, Barozzi I, Osterwalder M, Alkelai A, Ruzzo EK, Han Y, Vos ESM, Reznik-Wolf H, Hartman C, Shamir R, Weiss B, Shapiro R, Pode-Shakked B, Tatarskyy P, Milgrom R, Schvimer M, Barshack I, Imai DM, Coleman-Derr D, Dickel DE, Nord AS, Afzal V, van Bueren KL, Barnes RM, Black BL, Mayhew CN, Kuhar MF, Pitstick A, Tekman M, Stanescu HC, Wells JM, Kleta R, de Laat W, Goldstein DB, Pras E, Visel A, Lancet D, Anikster Y, Pennacchio LA. PMID: 31217582; PMCID: PMC7061489.
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Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin. Elife. 2019 02 08; 8. Poltavski DM, Colombier P, Hu J, Duron A, Black BL, Makita T. PMID: 30735130; PMCID: PMC6389285.
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Cardiovascular development and survival require Mef2c function in the myocardial but not the endothelial lineage. Dev Biol. 2019 01 15; 445(2):170-177. Materna SC, Sinha T, Barnes RM, Lammerts van Bueren K, Black BL. PMID: 30521808; PMCID: PMC6370303.
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Genomic analysis of transcriptional networks directing progression of cell states during MGE development. Neural Dev. 2018 09 14; 13(1):21. Sandberg M, Taher L, Hu J, Black BL, Nord AS, Rubenstein JLR. PMID: 30217225; PMCID: PMC6138899.
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Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites. Development. 2017 04 01; 144(7):1235-1241. Anderson CM, Hu J, Thomas R, Gainous TB, Celona B, Sinha T, Dickel DE, Heidt AB, Xu SM, Bruneau BG, Pollard KS, Pennacchio LA, Black BL. PMID: 28351867; PMCID: PMC5399617.
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Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice. Elife. 2017 01 31; 6. Overman J, Fontaine F, Moustaqil M, Mittal D, Sierecki E, Sacilotto N, Zuegg J, Robertson AAB, Holmes K, Salim AA, Mamidyala S, Butler MS, Robinson AS, Lesieur E, Johnston W, Alexandrov K, Black BL, Hogan BM, De Val S, Capon RJ, Carroll JS, Bailey TL, Koopman P, Jauch R, Cooper MA, Gambin Y, Francois M. PMID: 28137359; PMCID: PMC5283831.
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Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Elife. 2017 01 10; 6. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL. PMID: 28072389; PMCID: PMC5283830.
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Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11237-11242. Marín-Juez R, Marass M, Gauvrit S, Rossi A, Lai SL, Materna SC, Black BL, Stainier DY. PMID: 27647901; PMCID: PMC5056108.
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Modulation of tissue repair by regeneration enhancer elements. Nature. 2016 Apr 14; 532(7598):201-6. Kang J, Hu J, Karra R, Dickson AL, Tornini VA, Nachtrab G, Gemberling M, Goldman JA, Black BL, Poss KD. PMID: 27049946; PMCID: PMC4844022.
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MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016 Mar 01; 143(5):774-9. Barnes RM, Harris IS, Jaehnig EJ, Sauls K, Sinha T, Rojas A, Schachterle W, McCulley DJ, Norris RA, Black BL. PMID: 26811383; PMCID: PMC4813332.
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Nodal Signaling and Congenital Heart Defects. Etiology and Morphogenesis of Congenital Heart Disease. 2016 Jan 1; 183-192. Barnes BR, Black BB. .
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Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway. Development. 2015 Aug 15; 142(16):2775-80. Hu J, Verzi MP, Robinson AS, Tang PL, Hua LL, Xu SM, Kwok PY, Black BL. PMID: 26160899; PMCID: PMC4550968.
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Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2016 Jan-Feb; 18(1):31-40. Tapaltsyan V, Charles C, Hu J, Mindell D, Ahituv N, Wilson GM, Black BL, Viriot L, Klein OD. PMID: 26086993; PMCID: PMC4826035.
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Developmental biology: Diversity in the lymphatic vasculature. Nature. 2015 Jun 04; 522(7554):37-8. Hogan BM, Black BL. PMID: 25992543.
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Mef2c-F10N enhancer driven β-galactosidase (LacZ) and Cre recombinase mice facilitate analyses of gene function and lineage fate in neural crest cells. Dev Biol. 2015 Jun 01; 402(1):3-16. Aoto K, Sandell LL, Butler Tjaden NE, Yuen KC, Watt KE, Black BL, Durnin M, Trainor PA. PMID: 25794678; PMCID: PMC4433593.
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Myocyte enhancer factor 2C function in skeletal muscle is required for normal growth and glucose metabolism in mice. Skelet Muscle. 2015; 5:7. Anderson CM, Hu J, Barnes RM, Heidt AB, Cornelissen I, Black BL. PMID: 25789156; PMCID: PMC4364460.
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NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity. Cell Rep. 2014 Sep 25; 8(6):1639-1648. Ehlers ML, Celona B, Black BL. PMID: 25242327; PMCID: PMC4180018.
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An arterial-specific enhancer of the human endothelin converting enzyme 1 (ECE1) gene is synergistically activated by Sox17, FoxC2, and Etv2. Dev Biol. 2014 Nov 15; 395(2):379-389. Robinson AS, Materna SC, Barnes RM, De Val S, Xu SM, Black BL. PMID: 25179465; PMCID: PMC4252918.
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Specification of the mouse cardiac conduction system in the absence of Endothelin signaling. Dev Biol. 2014 Sep 15; 393(2):245-254. Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D, Black BL. PMID: 25050930; PMCID: PMC4143461.
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Abstract 327: ETS Factors Regulate the VEGF-Dependent, Arterial-Specific Expression of Dll4. Arteriosclerosis Thrombosis and Vascular Biology. 2014 May 1; 34(suppl_1). Dang DL, Wythe WJ, Devine DP, Boudreau BE, Artap AS, He HD, Schachterle SW, Stainier SD, Oettgen OP, Black BB, Bruneau BB, Fish FJ. .
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Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17921-6. Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR, Akiyama JA, van Bueren KL, Chines PS, Narisu N, NISC Comparative Sequencing Program, Black BL, Visel A, Pennacchio LA, Collins FS, National Institutes of Health Intramural Sequencing Center Comparative Sequencing Program Authors, NISC Comparative Sequencing Program Authors. PMID: 24127591; PMCID: PMC3816444.
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ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013 Jul 15; 26(1):45-58. Wythe JD, Dang LT, Devine WP, Boudreau E, Artap ST, He D, Schachterle W, Stainier DY, Oettgen P, Black BL, Bruneau BG, Fish JE. PMID: 23830865; PMCID: PMC3754838.
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Regulation of endothelial and hematopoietic development by the ETS transcription factor Etv2. Curr Opin Hematol. 2012 May; 19(3):199-205. Lammerts van Bueren K, Black BL. PMID: 22406820.
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Transcription factor pathways and congenital heart disease. Curr Top Dev Biol. 2012; 100:253-77. McCulley DJ, Black BL. PMID: 22449847; PMCID: PMC3684448.
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Chapter 3 Cardiac Myocyte Specification and Differentiation. Muscle. 2012 Jan 1; 25-34. Bruneau BB, Black BB. .
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Large-scale discovery of enhancers from human heart tissue. Nat Genet. 2011 Dec 04; 44(1):89-93. May D, Blow MJ, Kaplan T, McCulley DJ, Jensen BC, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Afzal V, Simpson PC, Rubin EM, Black BL, Bristow J, Pennacchio LA, Visel A. PMID: 22138689; PMCID: PMC3246570.
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Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development. 2011 Nov; 138(21):4721-32. Palencia-Desai S, Kohli V, Kang J, Chi NC, Black BL, Sumanas S. PMID: 21989916; PMCID: PMC3190385.
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ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15; 361(2):439-49. Schachterle W, Rojas A, Xu SM, Black BL. PMID: 22056786; PMCID: PMC3246565.
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Etsrp/Etv2 initiates endothelial/endocardial and inhibits myocardial differentiation by two distinct mechanisms in zebrafish embryos. Developmental Biology. 2011 Aug 1; 356(1):173. Palencia-Desai PS, Kohli KV, Kang KJ, Chi CN, Black BB, Sumanas SS. .
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FGF-dependent regulation of VEGF receptor 2 expression in mice. J Clin Invest. 2011 Jul; 121(7):2668-78. Murakami M, Nguyen LT, Hatanaka K, Schachterle W, Chen PY, Zhuang ZW, Black BL, Simons M. PMID: 21633168; PMCID: PMC3223828.
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The MADS box transcription factor MEF2C regulates melanocyte development and is a direct transcriptional target and partner of SOX10. Development. 2011 Jun; 138(12):2555-65. Agarwal P, Verzi MP, Nguyen T, Hu J, Ehlers ML, McCulley DJ, Xu SM, Dodou E, Anderson JP, Wei ML, Black BL. PMID: 21610032; PMCID: PMC3100711.
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Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 01; 351(1):62-9. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. PMID: 21185281; PMCID: PMC3039109.
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Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell. 2010 Dec 14; 19(6):903-12. Wang J, Greene SB, Bonilla-Claudio M, Tao Y, Zhang J, Bai Y, Huang Z, Black BL, Wang F, Martin JF. PMID: 21145505; PMCID: PMC3010389.
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ChIP-Seq identification of weakly conserved heart enhancers. Nat Genet. 2010 Sep; 42(9):806-10. Blow MJ, McCulley DJ, Li Z, Zhang T, Akiyama JA, Holt A, Plajzer-Frick I, Shoukry M, Wright C, Chen F, Afzal V, Bristow J, Ren B, Black BL, Rubin EM, Visel A, Pennacchio LA. PMID: 20729851; PMCID: PMC3138496.
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Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer. Dev Biol. 2010 Oct 15; 346(2):346-55. Rojas A, Schachterle W, Xu SM, Martín F, Black BL. PMID: 20692247; PMCID: PMC2945415.
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Development of the endocardium. Pediatr Cardiol. 2010 Apr; 31(3):391-9. Harris IS, Black BL. PMID: 20135106; PMCID: PMC2836465.
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Chapter 9.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease. Heart Development and Regeneration. 2010 Jan 1; 673-699. Black BB, Cripps CR. .
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An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo. Dev Dyn. 2009 Oct; 238(10):2588-98. Rojas A, Schachterle W, Xu SM, Black BL. PMID: 19777593; PMCID: PMC2827249.
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Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1. Pharmacogenet Genomics. 2009 Oct; 19(10):770-80. Ha Choi J, Wah Yee S, Kim MJ, Nguyen L, Ho Lee J, Kang JO, Hesselson S, Castro RA, Stryke D, Johns SJ, Kwok PY, Ferrin TE, Goo Lee M, Black BL, Ahituv N, Giacomini KM. PMID: 19745787; PMCID: PMC2976711.
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Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 03; 461(7260):95-8. Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG. PMID: 19727199; PMCID: PMC2753965.
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Erratum: Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature. 2009 Sep 1; 461(7263):550-550. Koshiba-Takeuchi KK, Mori MA, Kaynak KB, Cebra-Thomas CJ, Sukonnik ST, Georges GR, Latham LS, Beck BL, Henkelman HR, Black BB, Olson OE, Wade WJ, Takeuchi TJ, Nemer NM, Gilbert GS, Bruneau BB. .
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Isl1 is a direct transcriptional target of Forkhead transcription factors in second-heart-field-derived mesoderm. Dev Biol. 2009 Oct 15; 334(2):513-22. Kang J, Nathan E, Xu SM, Tzahor E, Black BL. PMID: 19580802; PMCID: PMC2928383.
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Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Dev Biol. 2009 Jul 15; 331(2):270-80. Lee Y, Hami D, De Val S, Kagermeier-Schenk B, Wills AA, Black BL, Weidinger G, Poss KD. PMID: 19445916; PMCID: PMC2821826.
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Transcriptional control of endothelial cell development. Dev Cell. 2009 Feb; 16(2):180-95. De Val S, Black BL. PMID: 19217421; PMCID: PMC2728550.
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Identification and characterization of proximal promoter polymorphisms in the human concentrative nucleoside transporter 2 (SLC28A2). J Pharmacol Exp Ther. 2009 Mar; 328(3):699-707. Yee SW, Shima JE, Hesselson S, Nguyen L, De Val S, Lafond RJ, Kawamoto M, Johns SJ, Stryke D, Kwok PY, Ferrin TE, Black BL, Gurwitz D, Ahituv N, Giacomini KM. PMID: 19098160; PMCID: PMC2682268.
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Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell. 2008 Dec 12; 135(6):1053-64. De Val S, Chi NC, Meadows SM, Minovitsky S, Anderson JP, Harris IS, Ehlers ML, Agarwal P, Visel A, Xu SM, Pennacchio LA, Dubchak I, Krieg PA, Stainier DY, Black BL. PMID: 19070576; PMCID: PMC2782666.
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BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development. Dev Dyn. 2008 Nov; 237(11):3200-9. McCulley DJ, Kang JO, Martin JF, Black BL. PMID: 18924235; PMCID: PMC2728547.
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A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17067-72. Khiem D, Cyster JG, Schwarz JJ, Black BL. PMID: 18955699; PMCID: PMC2579379.
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Genetic and functional interaction between transcription factors MEF2C and Dlx5/6 is required for craniofacial development. Developmental Biology. 2008 Jul 1; 319(2):595. Agarwal AP, Verzi VM, Black BB. .
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GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol. 2008 Sep; 28(17):5420-31. Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL. PMID: 18591257; PMCID: PMC2519727.
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Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev. 2008 Mar 15; 22(6):734-9. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY. PMID: 18347092; PMCID: PMC2275426.
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Transcriptional pathways in heart development. The FASEB Journal. 2008 Mar 1; 22:384.1-384.1. Black BB, Kang KJ, Harris HI, Schachterle SW. .
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Determinants of myogenic specificity within MyoD are required for noncanonical E box binding. Mol Cell Biol. 2007 Aug; 27(16):5910-20. Heidt AB, Rojas A, Harris IS, Black BL. PMID: 17562853; PMCID: PMC1952131.
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Transcriptional control of second heart field development. Developmental Biology. 2007 Jun 1; 306(1):291. Black BB, Kang KJ, Harris HI, Schachterle SW, Rojas RA. .
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The transcription factor MEF2C is required for craniofacial development. Dev Cell. 2007 Apr; 12(4):645-52. Verzi MP, Agarwal P, Brown C, McCulley DJ, Schwarz JJ, Black BL. PMID: 17420000; PMCID: PMC1920108.
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The heart's Da Vinci code: a Renaissance at Keystone. Development. 2007 May; 134(9):1631-3. Bruneau BG, Black BL. PMID: 17395645.
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An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007 Mar 09; 128(5):947-59. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. PMID: 17350578; PMCID: PMC2092439.
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Model systems for the study of heart development and disease. Seminars in Cell and Developmental Biology. 2007 Feb 1; 18(1):1-2. Schulz SR, Black BB. .
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Transcriptional pathways in second heart field development. Semin Cell Dev Biol. 2007 Feb; 18(1):67-76. Black BL. PMID: 17276708; PMCID: PMC1855211.
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Transcriptional Control of Cardiac Boundary Formation. Cardiovascular Development. 2007 Jan 1; 18:93-115. Rojas RA, Black BB. .
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In vivo enhancer analysis of human conserved non-coding sequences. Nature. 2006 Nov 23; 444(7118):499-502. Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, Minovitsky S, Dubchak I, Holt A, Lewis KD, Plajzer-Frick I, Akiyama J, De Val S, Afzal V, Black BL, Couronne O, Eisen MB, Visel A, Rubin EM. PMID: 17086198.
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Increased susceptibility to isoproterenol-induced cardiac hypertrophy and impaired weight gain in mice lacking the histidine-rich calcium-binding protein. Mol Cell Biol. 2006 Dec; 26(24):9315-26. Jaehnig EJ, Heidt AB, Greene SB, Cornelissen I, Black BL. PMID: 17030629; PMCID: PMC1698540.
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Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. Dev Biol. 2006 Aug 15; 296(2):437-49. Ai D, Liu W, Ma L, Dong F, Lu MF, Wang D, Verzi MP, Cai C, Gage PJ, Evans S, Black BL, Brown NA, Martin JF. PMID: 16836994; PMCID: PMC5851592.
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Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development. 2006 Jun; 133(12):2419-33. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, Frank DU, Moon AM. PMID: 16720879; PMCID: PMC1780034.
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A single mutation causes a spectrum of cardiovascular defects: the potential role of genetic modifiers, epigenetic influences, and stochastic events in phenotypic variability. J Mol Cell Cardiol. 2006 Feb; 40(2):201-4. Black BL. PMID: 16337649.
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The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol. 2005 Nov 01; 287(1):134-45. Verzi MP, McCulley DJ, De Val S, Dodou E, Black BL. PMID: 16188249.
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Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development. 2005 Aug; 132(15):3405-17. Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL. PMID: 15987774.
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Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis. 2005 May; 42(1):28-32. Heidt AB, Black BL. PMID: 15828002.
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Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005 May; 132(10):2463-74. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. PMID: 15843409.
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Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development. 2005 May; 132(10):2451-62. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. PMID: 15843414.
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Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol. 2004 Nov 15; 275(2):424-34. De Val S, Anderson JP, Heidt AB, Khiem D, Xu SM, Black BL. PMID: 15501228.
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Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development. 2004 Aug; 131(16):3931-42. Dodou E, Verzi MP, Anderson JP, Xu SM, Black BL. PMID: 15253934.
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HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. Mol Cell Biol. 2004 May; 24(9):3757-68. Anderson JP, Dodou E, Heidt AB, De Val SJ, Jaehnig EJ, Greene SB, Olson EN, Black BL. PMID: 15082771; PMCID: PMC387749.
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mef2c is activated directly by myogenic basic helix-loop-helix proteins during skeletal muscle development in vivo. Mech Dev. 2003 Sep; 120(9):1021-32. Dodou E, Xu SM, Black BL. PMID: 14550531.
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Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med. 2002 Nov; 8(11):1303-9. Naya FJ, Black BL, Wu H, Bassel-Duby R, Richardson JA, Hill JA, Olson EN. PMID: 12379849.
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N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Dev Biol. 2002 Sep 01; 249(1):174-90. Verzi MP, Anderson JP, Dodou E, Kelly KK, Greene SB, North BJ, Cripps RM, Black BL. PMID: 12217327.
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Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol. 1999 Apr; 19(4):2853-62. Wilson-Rawls J, Molkentin JD, Black BL, Olson EN. PMID: 10082551; PMCID: PMC84078.
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8 Control of Cardiac Development by the MEF2 Family of Transcription Factors. Heart Development. 1999 Jan 1; (J. Biol. Chem.2701995):131-142. Black BB, Olson OE. .
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Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2. Mol Cell Biol. 1998 Jan; 18(1):69-77. Black BL, Molkentin JD, Olson EN. PMID: 9418854; PMCID: PMC121453.
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Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol. 1998; 14:167-96. Black BL, Olson EN. PMID: 9891782.
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The MEF2A 3' untranslated region functions as a cis-acting translational repressor. Mol Cell Biol. 1997 May; 17(5):2756-63. Black BL, Lu J, Olson EN. PMID: 9111346; PMCID: PMC232126.
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Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996 Oct 25; 271(43):26659-63. Black BL, Ligon KL, Zhang Y, Olson EN. PMID: 8900141.
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MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 1996 Jul; 16(7):3814-24. Molkentin JD, Firulli AB, Black BL, Martin JF, Hustad CM, Copeland N, Jenkins N, Lyons G, Olson EN. PMID: 8668199; PMCID: PMC231378.
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Mutational analysis of the DNA binding, dimerization, and transcriptional activation domains of MEF2C. Mol Cell Biol. 1996 Jun; 16(6):2627-36. Molkentin JD, Black BL, Martin JF, Olson EN. PMID: 8649370; PMCID: PMC231253.
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Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins. Cell. 1995 Dec 29; 83(7):1125-36. Molkentin JD, Black BL, Martin JF, Olson EN. PMID: 8548800.
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The mouse MRF4 promoter is trans-activated directly and indirectly by muscle-specific transcription factors. J Biol Chem. 1995 Feb 17; 270(7):2889-92. Black BL, Martin JF, Olson EN. PMID: 7852366.
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Effect of vesicular stomatitis virus matrix protein on host-directed translation in vivo. J Virol. 1994 Jan; 68(1):555-60. Black BL, Brewer G, Lyles DS. PMID: 8254771; PMCID: PMC236321.
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The role of vesicular stomatitis virus matrix protein in inhibition of host-directed gene expression is genetically separable from its function in virus assembly. J Virol. 1993 Aug; 67(8):4814-21. Black BL, Rhodes RB, McKenzie M, Lyles DS. PMID: 8392615; PMCID: PMC237868.
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Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders. Biol Psychiatry. 1993 Apr 15-May 1; 33(8-9):647-50. Stein MB, Black B, Brown TM, Uhde TW. PMID: 8329495.
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Vesicular stomatitis virus matrix protein inhibits host cell-directed transcription of target genes in vivo. J Virol. 1992 Jul; 66(7):4058-64. Black BL, Lyles DS. PMID: 1318397; PMCID: PMC241208.
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Focal toxicity of oxysterols in vascular smooth muscle cell culture. A model of the atherosclerotic core region. Am J Pathol. 1990 Aug; 137(2):425-34. Guyton JR, Black BL, Seidel CL. PMID: 2201200; PMCID: PMC1877599.
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