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Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology. JAMA Netw Open. 2026 Feb 02; 9(2):e2559113. Gray SL, Yu O, Gatto NM, Marcum ZA, Latimer CS, Postupna N, Su YR, Barthold D, van Dalen JW, Richard E, Keene CD, Shaw PA, McEvoy LK, Larson EB, Crane PK. PMID: 41670993; PMCID: PMC12895290.
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Evaluating the association of apolipoprotein E genotype and cognitive resilience in SuperAgers. Alzheimers Dement. 2026 Jan; 22(1):e71024. Durant A, Mukherjee S, Lee ML, Choi SE, Scollard P, Klinedinst BS, Trittschuh EH, Mez J, Farrer LA, Gifford KA, Cruchaga C, Hassenstab J, Naj AC, Wang LS, Johnson SC, Engelman CD, Kukull WA, Keene CD, Saykin AJ, Cuccaro ML, Kunkle BW, Pericak-Vance MA, Martin ER, Bennett DA, Barnes LL, Schneider JA, Bush WS, Haines JL, Mayeux R, Vardarajan BN, Albert MS, Thompson PM, Jefferson AL, Alzheimer's Disease Neuroimaging Initiative (ADNI)*Alzheimer's Disease Genetics Consortium (ADGC)The, Crane PK, Dumitrescu L, Archer DB, Hohman TJ, Gaynor LS. PMID: 41542929; PMCID: PMC12809718.
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Single-cell landscape of sex-specific drivers of Alzheimer's disease. Alzheimers Dement. 2025 Dec; 21(12):e71041. Wu Y, Travaglini KJ, Gabitto M, Keene CD, Dunn AR, Kaczorowski CC, De Jager PL, Menon V, Schneider JA, Bennett DA, Dumitrescu L, Hohman TJ. PMID: 41457042; PMCID: PMC12745176.
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Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort. J Neuropathol Exp Neurol. 2025 Dec 01; 84(12):1174-1190. Selmanovic E, Seifert AC, Delman BN, Pruyser A, Thorn EL, Nolan AL, Keene CD, Walker JM, Crary JF, Hof PR, Folkerth RD, Dams-O'Connor K. PMID: 41108192; PMCID: PMC12713551.
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Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B. Alzheimers Dement. 2025 Nov; 21(11):e70760. Godrich D, Pasteris J, Martin ER, Kunkle B, Naj AC, Hamilton K, Wang H, Lee WP, Dumitrescu L, Hohman TJ, Mayeux R, Larson EB, Crane PK, Keene CD, Latimer C, Mukherjee S, Kofler J, Kamboh MI, Bennett DA, Molina-Porcel L, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Rundek T, Kukull W, Montine T, Beecham GW, Alzheimer's Disease Genetics Consortium (ADGC). PMID: 41208712; PMCID: PMC12598407.
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The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols. Alzheimers Dement. 2025 Sep; 21(9):e70630. McGrath S, Hull E, Dunbar MD, Prescott J, Keyser AJ, MacLean E, Darvas M, Latimer C, Moreno J, MacCoss MJ, Kauffman M, Litwin P, Castelhano M, Kaeberlein M, Keene CD, Dog Aging Project Consortium. PMID: 40995864; PMCID: PMC12461415.
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Tri-snRNP activity modulates tauopathy phenotypes. NAR Mol Med. 2025 Jul; 2(3):ugaf032. LeBlanc KR, Eck RJ, Saxton AD, McMillan PJ, Wheeler JM, Liachko NF, Keene CD, Latimer CS, Kow RL, Kraemer BC. PMID: 41256288; PMCID: PMC12469191.
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Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer's disease. Brain Commun. 2025; 7(3):fcaf245. Barsoum S, Latimer CS, Nolan AL, Barrett A, Chang K, Troncoso JC, Keene CD, Benjamini D. PMID: 40585810; PMCID: PMC12203664.
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Prevention of concussion and long-term effects of repetitive traumatic brain injury: Unanimous consensus from the Cantu Concussion Summit. PM R. 2025 May; 17(5):563-566. Cantu RC, Sills AK, Alosco ML, Arbogast KB, Bazarian JJ, Bieniek KF, Crandall JR, Iverson GL, Katz DI, Keene CD, Leddy JJ, Mack CD, McKee AC, Meehan WP, Mez J, Nowinski CJ, Okonkwo DO, Solomon GS, Stein TD, Tartaglia MC, Zafonte RD, Daneshvar DH. PMID: 40040623.
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Data-independent acquisition proteomic analysis of the brain microvasculature in Alzheimer's disease identifies major pathways of dysfunction and upregulation of cytoprotective responses. Fluids Barriers CNS. 2024 Oct 21; 21(1):84. Erickson MA, Johnson RS, Damodarasamy M, MacCoss MJ, Keene CD, Banks WA, Reed MJ. PMID: 39434151; PMCID: PMC11492478.
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Hereditary spastic paraplegia with thin corpus callosum and SPG11 mutation: A neuropathological evaluation. Neuropathology. 2025 Apr; 45(2):123-134. Scherpelz KP, Yoda RA, Jayadev S, Davis MY, Hincks JC, Liachko NF, Bragg RM, Cochoit A, MacDonald CL, Keene CD, Bird TD, Latimer CS. PMID: 39391989; PMCID: PMC12005084.
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SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease. Nat Aging. 2024 Oct; 4(10):1331-1334. Hawrylycz M, Kaplan ES, Travaglini KJ, Gabitto MI, Miller JA, Ng L, Close JL, Hodge RD, Long B, Mollenkopf T, Mufti S, Gatto NM, Larson EB, Crane PK, Grabowski TJ, Keene CD, Lein ES. PMID: 39402332; PMCID: PMC11577961.
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B-BIND: Biophysical Bayesian Inference for Neurodegenerative Dynamics. bioRxiv. 2024 Jul 31. Agrawal A, Rachleff VM, Travaglini KJ, Mukherjee S, Crane PK, Hawrylycz M, Keene CD, Lein E, Mena GE, Gabitto MI. PMID: 38915664; PMCID: PMC11195076.
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mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease. PLoS Genet. 2024 Jul; 20(7):e1011359. Smukowski SN, Danyko C, Somberg J, Kaufman EJ, Course MM, Postupna N, Barker-Haliski M, Keene CD, Valdmanis PN. PMID: 39074152; PMCID: PMC11309398.
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Suppression of eEF2 phosphorylation alleviates synaptic failure and cognitive deficits in mouse models of Down syndrome. Alzheimers Dement. 2024 08; 20(8):5357-5374. Wang X, Yang Q, Zhou X, Keene CD, Ryazanov AG, Ma T. PMID: 38934363; PMCID: PMC11350057.
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Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer's disease. Acta Neuropathol. 2024 06 19; 147(1):105. Ollen-Bittle N, Pejhan S, Pasternak SH, Keene CD, Zhang Q, Whitehead SN. PMID: 38896306; PMCID: PMC11577574.
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Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. Elife. 2024 Jun 19; 12. Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, Williams-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, Oakley DH, Frosch MP, Young SI, Van Leemput K, Dalca AV, Fischl B, MacDonald CL, Keene CD, Hyman BT, Iglesias JE. PMID: 38896568; PMCID: PMC11186625.
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Evidence of mutant huntingtin and tau-related pathology within neuronal grafts in Huntington's disease cases. Neurobiol Dis. 2024 08; 198:106542. Salem S, Kilgore MD, Anwer M, Maxan A, Child D, Bird TD, Keene CD, Cicchetti F, Latimer C. PMID: 38810948; PMCID: PMC12448652.
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α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden. Alzheimers Dement. 2024 06; 20(6):4351-4365. Levin J, Baiardi S, Quadalti C, Rossi M, Mammana A, Vöglein J, Bernhardt A, Perrin RJ, Jucker M, Preische O, Hofmann A, Höglinger GU, Cairns NJ, Franklin EE, Chrem P, Cruchaga C, Berman SB, Chhatwal JP, Daniels A, Day GS, Ryan NS, Goate AM, Gordon BA, Huey ED, Ibanez L, Karch CM, Lee JH, Llibre-Guerra J, Lopera F, Masters CL, Morris JC, Noble JM, Renton AE, Roh JH, Frosch MP, Keene CD, McLean C, Sanchez-Valle R, Schofield PR, Supnet-Bell C, Xiong C, Giese A, Hansson O, Bateman RJ, McDade E, Dominantly Inherited Alzheimer Network, Parchi P. PMID: 38666355; PMCID: PMC11180868.
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Mapping human tissues with highly multiplexed RNA in situ hybridization. Nat Commun. 2024 Mar 20; 15(1):2511. Kalhor K, Chen CJ, Lee HS, Cai M, Nafisi M, Que R, Palmer CR, Yuan Y, Zhang Y, Li X, Song J, Knoten A, Lake BB, Gaut JP, Keene CD, Lein E, Kharchenko PV, Chun J, Jain S, Fan JB, Zhang K. PMID: 38509069; PMCID: PMC10954689.
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Clinical Outcomes After Traumatic Brain Injury and Exposure to Extracranial Surgery: A TRACK-TBI Study. JAMA Surg. 2024 03 01; 159(3):248-259. Roberts CJ, Barber J, Temkin NR, Dong A, Robertson CS, Valadka AB, Yue JK, Markowitz AJ, Manley GT, Nelson LD, Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators, Badjatia N, Diaz-Arrastia R, Duhaime AC, Feeser VR, Gopinath S, Grandhi R, Jha R, Keene CD, Madden C, McCrea M, Merchant R, Ngwenya LB, Rodgers RB, Schnyer D, Taylor SR, Zafonte R. PMID: 38091011; PMCID: PMC10719833.
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Co-registration of MALDI-MSI and histology demonstrates gangliosides co-localize with amyloid beta plaques in Alzheimer's disease. Res Sq. 2024 Feb 27. Ollen-Bittle N, Pejhan S, Pasternak SH, Keene CD, Zhang Q, Whitehead SN. PMID: 38463949; PMCID: PMC10925476.
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Lewy body pathology modifies risk factors for cerebral amyloid angiopathy when comorbid with Alzheimer's disease pathology. Alzheimers Dement. 2024 04; 20(4):2564-2574. Pillai JA, Bena J, Tousi B, Rothenberg K, Keene CD, Leverenz JB. PMID: 38353367; PMCID: PMC11032524.
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APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's disease pathology. Neuron. 2024 Apr 03; 112(7):1110-1116.e5. Chemparathy A, Le Guen Y, Chen S, Lee EG, Leong L, Gorzynski JE, Jensen TD, Ferrasse A, Xu G, Xiang H, Belloy ME, Kasireddy N, Peña-Tauber A, Williams K, Stewart I, Talozzi L, Wingo TS, Lah JJ, Jayadev S, Hales CM, Peskind E, Child DD, Roeber S, Keene CD, Cong L, Ashley EA, Yu CE, Greicius MD. PMID: 38301647; PMCID: PMC10994769.
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Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. bioRxiv. 2024 Jan 30. Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, William-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, Oakley DH, Frosch MP, Young SI, Van Leemput K, Dalca AV, FIschl B, Mac Donald CL, Keene CD, Hyman BT, Iglesias JE. PMID: 37333251; PMCID: PMC10274889.
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Advancements in high-resolution 3D microscopy analysis of endosomal morphology in postmortem Alzheimer's disease brains. Front Neurosci. 2023; 17:1321680. Rose SE, Williams CA, Hailey DW, Mishra S, Kirkland A, Keene CD, Garden GA, Jayadev S, Young JE. PMID: 38292900; PMCID: PMC10824887.
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Neuropathologic Burden and Dementia in Nonagenarians and Centenarians: Comparison of 2 Community-Based Cohorts Neurology. 2024 02 13; 102(3):e208060. Cholerton B, Latimer CS, Crane PK, Corrada MM, Gibbons LE, Larson EB, Kawas CH, Keene CD, Montine TJ. PMID: 38175995; PMCID: PMC11097771.
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Profiles of Cognitive Functioning at 6 Months After Traumatic Brain Injury Among Patients in Level I Trauma Centers: A TRACK-TBI Study. JAMA Netw Open. 2023 12 01; 6(12):e2349118. Bryant AM, Rose NB, Temkin NR, Barber JK, Manley GT, McCrea MA, Nelson LD, TRACK-TBI Investigators, Badjatia N, Gopinath S, Keene CD, Madden C, Ngwenya LB, Puccio A, Robertson C, Schnyer D, Taylor SR, Yue JK. PMID: 38147333; PMCID: PMC10751593.
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Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease. Proc Natl Acad Sci U S A. 2023 11 07; 120(45):e2301534120. Niere F, Uneri A, McArdle CJ, Deng Z, Egido-Betancourt HX, Cacheaux LP, Namjoshi SV, Taylor WC, Wang X, Barth SH, Reynoldson C, Penaranda J, Stierer MP, Heaney CF, Craft S, Keene CD, Ma T, Raab-Graham KF. PMID: 37903257; PMCID: PMC10636362.
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Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex. Science. 2023 10 13; 382(6667):eadf0805. Chartrand T, Dalley R, Close J, Goriounova NA, Lee BR, Mann R, Miller JA, Molnar G, Mukora A, Alfiler L, Baker K, Bakken TE, Berg J, Bertagnolli D, Braun T, Brouner K, Casper T, Csajbok EA, Dee N, Egdorf T, Enstrom R, Galakhova AA, Gary A, Gelfand E, Goldy J, Hadley K, Heistek TS, Hill D, Jorstad N, Kim L, Kocsis AK, Kruse L, Kunst M, Leon G, Long B, Mallory M, McGraw M, McMillen D, Melief EJ, Mihut N, Ng L, Nyhus J, Oláh G, Ozsvár A, Omstead V, Peterfi Z, Pom A, Potekhina L, Rajanbabu R, Rozsa M, Ruiz A, Sandle J, Sunkin SM, Szots I, Tieu M, Toth M, Trinh J, Vargas S, Vumbaco D, Williams G, Wilson J, Yao Z, Barzo P, Cobbs C, Ellenbogen RG, Esposito L, Ferreira M, Gouwens NW, Grannan B, Gwinn RP, Hauptman JS, Jarsky T, Keene CD, Ko AL, Koch C, Ojemann JG, Patel A, Ruzevick J, Silbergeld DL, Smith K, Sorensen SA, Tasic B, Ting JT, Waters J, de Kock CPJ, Mansvelder HD, Tamas G, Zeng H, Kalmbach B, Lein ES. PMID: 37824667; PMCID: PMC11864503.
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Single-cell DNA methylation and 3D genome architecture in the human brain. Science. 2023 10 13; 382(6667):eadf5357. Tian W, Zhou J, Bartlett A, Zeng Q, Liu H, Castanon RG, Kenworthy M, Altshul J, Valadon C, Aldridge A, Nery JR, Chen H, Xu J, Johnson ND, Lucero J, Osteen JK, Emerson N, Rink J, Lee J, Li YE, Siletti K, Liem M, Claffey N, O'Connor C, Yanny AM, Nyhus J, Dee N, Casper T, Shapovalova N, Hirschstein D, Ding SL, Hodge R, Levi BP, Keene CD, Linnarsson S, Lein E, Ren B, Behrens MM, Ecker JR. PMID: 37824674; PMCID: PMC10572106.
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A comparative atlas of single-cell chromatin accessibility in the human brain. Science. 2023 10 13; 382(6667):eadf7044. Li YE, Preissl S, Miller M, Johnson ND, Wang Z, Jiao H, Zhu C, Wang Z, Xie Y, Poirion O, Kern C, Pinto-Duarte A, Tian W, Siletti K, Emerson N, Osteen J, Lucero J, Lin L, Yang Q, Zhu Q, Zemke N, Espinoza S, Yanny AM, Nyhus J, Dee N, Casper T, Shapovalova N, Hirschstein D, Hodge RD, Linnarsson S, Bakken T, Levi B, Keene CD, Shang J, Lein E, Wang A, Behrens MM, Ecker JR, Ren B. PMID: 37824643; PMCID: PMC10852054.
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Interindividual variation in human cortical cell type abundance and expression. Science. 2023 10 13; 382(6667):eadf2359. Johansen N, Somasundaram S, Travaglini KJ, Yanny AM, Shumyatcher M, Casper T, Cobbs C, Dee N, Ellenbogen R, Ferreira M, Goldy J, Guzman J, Gwinn R, Hirschstein D, Jorstad NL, Keene CD, Ko A, Levi BP, Ojemann JG, Pham T, Shapovalova N, Silbergeld D, Sulc J, Torkelson A, Tung H, Smith K, Lein ES, Bakken TE, Hodge RD, Miller JA. PMID: 37824649; PMCID: PMC11702338.
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Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex. Science. 2023 10 13; 382(6667):eadf6484. Lee BR, Dalley R, Miller JA, Chartrand T, Close J, Mann R, Mukora A, Ng L, Alfiler L, Baker K, Bertagnolli D, Brouner K, Casper T, Csajbok E, Donadio N, Driessens SLW, Egdorf T, Enstrom R, Galakhova AA, Gary A, Gelfand E, Goldy J, Hadley K, Heistek TS, Hill D, Hou WH, Johansen N, Jorstad N, Kim L, Kocsis AK, Kruse L, Kunst M, León G, Long B, Mallory M, Maxwell M, McGraw M, McMillen D, Melief EJ, Molnar G, Mortrud MT, Newman D, Nyhus J, Opitz-Araya X, Ozsvár A, Pham T, Pom A, Potekhina L, Rajanbabu R, Ruiz A, Sunkin SM, Szöts I, Taskin N, Thyagarajan B, Tieu M, Trinh J, Vargas S, Vumbaco D, Waleboer F, Walling-Bell S, Weed N, Williams G, Wilson J, Yao S, Zhou T, Barzó P, Bakken T, Cobbs C, Dee N, Ellenbogen RG, Esposito L, Ferreira M, Gouwens NW, Grannan B, Gwinn RP, Hauptman JS, Hodge R, Jarsky T, Keene CD, Ko AL, Korshoej AR, Levi BP, Meier K, Ojemann JG, Patel A, Ruzevick J, Silbergeld DL, Smith K, Sørensen JC, Waters J, Zeng H, Berg J, Capogna M, Goriounova NA, Kalmbach B, de Kock CPJ, Mansvelder HD, Sorensen SA, Tamas G, Lein ES, Ting JT. PMID: 37824669; PMCID: PMC12229143.
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Mapping the individual human cortex using multidimensional MRI and unsupervised learning. Brain Commun. 2023; 5(6):fcad258. Kundu S, Barsoum S, Ariza J, Nolan AL, Latimer CS, Keene CD, Basser PJ, Benjamini D. PMID: 37953850; PMCID: PMC10638106.
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Unveiling Resilience to Alzheimer's Disease: Insights From Brain Regional Proteomic Markers. Neurosci Insights. 2023; 18:26331055231201600. Huang Z, Merrihew GE, Larson EB, Park J, Plubell D, Fox EJ, Montine KS, Keene CD, Latimer CS, Zou JY, MacCoss MJ, Montine TJ. PMID: 37810186; PMCID: PMC10557413.
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Ferroptosis of Microglia in Aging Human White Matter Injury. Ann Neurol. 2023 12; 94(6):1048-1066. Adeniyi PA, Gong X, MacGregor E, Degener-O'Brien K, McClendon E, Garcia M, Romero O, Russell J, Srivastava T, Miller J, Keene CD, Back SA. PMID: 37605362; PMCID: PMC10840747.
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Adipocyte-Derived Small Extracellular Vesicles from Patients with Alzheimer Disease Carry miRNAs Predicted to Target the CREB Signaling Pathway in Neurons. Int J Mol Sci. 2023 Sep 13; 24(18). Batabyal RA, Bansal A, Cechinel LR, Authelet K, Goldberg M, Nadler E, Keene CD, Jayadev S, Domoto-Reilly K, Li G, Peskind E, Hashimoto-Torii K, Buchwald D, Freishtat RJ. PMID: 37762325; PMCID: PMC10530811.
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Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2. Acta Neuropathol. 2023 11; 146(5):771-775. Song H, Tomasevich A, Acheampong KK, Schaff DL, Shaffer SM, Dolle JP, Johnson VE, Mikytuck B, Lee EB, Nolan A, Keene CD, Weiss SR, Stewart W, Smith DH. PMID: 37624381; PMCID: PMC10592095.
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Cross-species comparative analysis of single presynapses. Sci Rep. 2023 08 24; 13(1):13849. Berson E, Gajera CR, Phongpreecha T, Perna A, Bukhari SA, Becker M, Chang AL, De Francesco D, Espinosa C, Ravindra NG, Postupna N, Latimer CS, Shively CA, Register TC, Craft S, Montine KS, Fox EJ, Keene CD, Bendall SC, Aghaeepour N, Montine TJ. PMID: 37620363; PMCID: PMC10449792.
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Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain. 2023 08 01; 146(8):3206-3220. McMillan PJ, Benbow SJ, Uhrich R, Saxton A, Baum M, Strovas T, Wheeler JM, Baker J, Liachko NF, Keene CD, Latimer CS, Kraemer BC. PMID: 36732296; PMCID: PMC10393409.
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Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. medRxiv. 2023 Jul 08. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, Kuksa PP, Li D, Lucio da Fonseca E, Mez JB, Palmer EL, Pillai J, Sherva RM, Song YE, Zhang X, Iqbal T, Pathak O, Valladares O, Kuzma AB, Abner E, Adams PM, Aguirre A, Albert MS, Albin RL, Allen M, Alvarez L, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Ayres G, Baldwin CT, Barber RC, Barnes LL, Barral S, Beach TG, Becker JT, Beecham GW, Beekly D, Benitez BA, Bennett D, Bertelson J, Bird TD, Blacker D, Boeve BF, Bowen JD, Boxer A, Brewer J, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cantwell LB, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Chasse S, Chesselet MF, Chin NA, Chui HC, Chung J, Craft S, Crane PK, Cribbs DH, Crocco EA, Cruchaga C, Cuccaro ML, Cullum M, Darby E, Davis B, De Jager PL, DeCarli C, DeToledo J, Dick M, Dickson DW, Dombroski BA, Doody RS, Duara R, Ertekin-Taner N, Evans DA, Faber KM, Fairchild TJ, Fallon KB, Fardo DW, Farlow MR, Fernandez-Hernandez V, Ferris S, Foroud TM, Frosch MP, Fulton-Howard B, Galasko DR, Gamboa A, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Goate AM, Grabowski TJ, Graff-Radford NR, Green RC, Growdon JH, Hakonarson H, Hall J, Hamilton RL, Harari O, Hardy J, Harrell LE, Head E, Henderson VW, Hernandez M, Hohman T, Honig LS, Huebinger RM, Huentelman MJ, Hulette CM, Hyman BT, Hynan LS, Ibanez L, Jarvik GP, Jayadev S, Jin LW, Johnson K, Johnson L, Kamboh MI, Karydas AM, Katz MJ, Kauwe JS, Kaye JA, Keene CD, Khaleeq A, Kim R, Knebl J, Kowall NW, Kramer JH, Kukull WA, LaFerla FM, Lah JJ, Larson EB, Lerner A, Leverenz JB, Levey AI, Lieberman AP, Lipton RB, Logue M, Lopez OL, Lunetta KL, Lyketsos CG, Mains D, Margaret FE, Marson DC, Martin ERR, Martiniuk F, Mash DC, Masliah E, Massman P, Masurkar A, McCormick WC, McCurry SM, McDavid AN, McDonough S, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Montine TJ, Monuki ES, Morris JC, Mukherjee S, Myers AJ, Nguyen T, O'Bryant S, Olichney JM, Ory M, Palmer R, Parisi JE, Paulson HL, Pavlik V, Paydarfar D, Perez V, Peskind E, Petersen RC, Pierce A, Polk M, Poon WW, Potter H, Qu L, Quiceno M, Quinn JF, Raj A, Raskind M, Reiman EM, Reisberg B, Reisch JS, Ringman JM, Roberson ED, Rodriguear M, Rogaeva E, Rosen HJ, Rosenberg RN, Royall DR, Sager MA, Sano M, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Slifer SH, Small S, Smith AG, Smith JP, Sonnen JA, Spina S, St George-Hyslop P, Stern RA, Stevens AB, Strittmatter SM, Sultzer D, Swerdlow RH, Tanzi RE, Tilson JL, Trojanowski JQ, Troncoso JC, Tsuang DW, Van Deerlin VM, van Eldik LJ, Vance JM, Vardarajan BN, Vassar R, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Whitehead PL, Wijsman EM, Wilhelmsen KC, Williams B, Williamson J, Wilms H, Wingo TS, Wisniewski T, et al. PMID: 37461624; PMCID: PMC10350126.
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Performance of a condensed protocol to assess limbic-predominant age-related TDP-43 encephalopathy neuropathologic change. J Neuropathol Exp Neurol. 2023 06 20; 82(7):611-619. Maioli H, Mittenzwei R, Shofer JB, Scherpelz KP, Marshall D, Nolan AL, Nelson PT, Keene CD, Latimer CS. PMID: 37195467; PMCID: PMC10280345.
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Clonal hematopoiesis is associated with protection from Alzheimer's disease. Nat Med. 2023 07; 29(7):1662-1670. Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, Ma L, Chrostek MR, Ahmad H, Nachun D, Yao W, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Beiser A, Bick AG, Bis JC, Fornage M, Longstreth WT, Lopez OL, Natarajan P, Psaty BM, Satizabal CL, Weinstock J, Larson EB, Crane PK, Keene CD, Seshadri S, Satpathy AT, Montine TJ, Jaiswal S. PMID: 37322115; PMCID: PMC10353941.
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Target cell-specific synaptic dynamics of excitatory to inhibitory neuron connections in supragranular layers of human neocortex. Elife. 2023 05 30; 12. Kim MH, Radaelli C, Thomsen ER, Monet D, Chartrand T, Jorstad NL, Mahoney JT, Taormina MJ, Long B, Baker K, Bakken TE, Campagnola L, Casper T, Clark M, Dee N, D'Orazi F, Gamlin C, Kalmbach BE, Kebede S, Lee BR, Ng L, Trinh J, Cobbs C, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Sorensen SA, Berg J, Smith KA, Nicovich PR, Jarsky T, Zeng H, Ting JT, Levi BP, Lein E. PMID: 37249212; PMCID: PMC10332811.
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Human microglia show unique transcriptional changes in Alzheimer's disease. Nat Aging. 2023 07; 3(7):894-907. Prater KE, Green KJ, Mamde S, Sun W, Cochoit A, Smith CL, Chiou KL, Heath L, Rose SE, Wiley J, Keene CD, Kwon RY, Snyder-Mackler N, Blue EE, Logsdon B, Young JE, Shojaie A, Garden GA, Jayadev S. PMID: 37248328; PMCID: PMC10353942.
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Integrated multimodal cell atlas of Alzheimer's disease. Res Sq. 2023 May 23. Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Brouner K, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Compos J, Cool J, Valera Cuevas NJ, Dalley R, Darvas M, Ding SL, Dolbeare T, Mac Donald CL, Egdorf T, Esposito L, Ferrer R, Gala R, Gary A, Gloe J, Guilford N, Guzman J, Ho W, Jarksy T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore M, Kirkland A, Kunst M, Lee BR, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus J, Olsen PA, Pacleb M, Pham T, Pom CA, Postupna N, Ruiz A, Schantz AM, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting J, Torkelson A, Tran T, Wang MQ, Waters J, Wilson AM, Haynor D, Gatto N, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith K, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES. PMID: 37292694; PMCID: PMC10246227.
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Alzheimer's Disease-Related Dementias Summit 2022: National Research Priorities for the Investigation of Post-Traumatic Brain Injury Alzheimer's Disease and Related Dementias. J Neurotrauma. 2023 08; 40(15-16):1512-1523. Dams-O'Connor K, Awwad HO, Hoffman S, Pugh MJ, Johnson VE, Keene CD, McGavern L, Mukherjee P, Opanashuk L, Umoh N, Sopko G, Zetterberg H. PMID: 36927167; PMCID: PMC10494902.
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A peptide-centric quantitative proteomics dataset for the phenotypic assessment of Alzheimer's disease. Sci Data. 2023 04 14; 10(1):206. Merrihew GE, Park J, Plubell D, Searle BC, Keene CD, Larson EB, Bateman R, Perrin RJ, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Montine TJ, MacCoss MJ. PMID: 37059743; PMCID: PMC10104800.
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Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures. J Neuroinflammation. 2023 Mar 07; 20(1):60. Aloi MS, Prater KE, Sánchez REA, Beck A, Pathan JL, Davidson S, Wilson A, Keene CD, de la Iglesia H, Jayadev S, Garden GA. PMID: 36879321; PMCID: PMC9990295.
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The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. Lancet Healthy Longev. 2023 03; 4(3):e115-e125. Nichols E, Merrick R, Hay SI, Himali D, Himali JJ, Hunter S, Keage HAD, Latimer CS, Scott MR, Steinmetz JD, Walker JM, Wharton SB, Wiedner CD, Crane PK, Keene CD, Launer LJ, Matthews FE, Schneider J, Seshadri S, White L, Brayne C, Vos T. PMID: 36870337; PMCID: PMC9977689.
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The status of digital pathology and associated infrastructure within Alzheimer's Disease Centers. J Neuropathol Exp Neurol. 2023 02 21; 82(3):202-211. Scalco R, Hamsafar Y, White CL, Schneider JA, Reichard RR, Prokop S, Perrin RJ, Nelson PT, Mooney S, Lieberman AP, Kukull WA, Kofler J, Keene CD, Kapasi A, Irwin DJ, Gutman DA, Flanagan ME, Crary JF, Chan KC, Murray ME, Dugger BN. PMID: 36692179; PMCID: PMC9941826.
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Association of Traumatic Brain Injury with Late Life Neuropathological Outcomes in a Community-Based Cohort. J Alzheimers Dis. 2023; 93(3):949-961. Gibbons LE, Power MC, Walker RL, Kumar RG, Murphy A, Latimer CS, Nolan AL, Melief EJ, Beller A, Bogdani M, Keene CD, Larson EB, Crane PK, Dams-O'Connor K. PMID: 37125552; PMCID: PMC10860614.
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Protocol for the Systematic Fixation, Circuit-Based Sampling, and Qualitative and Quantitative Neuropathological Analysis of Human Brain Tissue. Methods Mol Biol. 2023; 2561:3-30. Latimer CS, Melief EJ, Ariza-Torres J, Howard K, Keen AR, Keene LM, Schantz AM, Sytsma TM, Wilson AM, Grabowski TJ, Darvas M, O'Connor KD, Nolan AL, Edlow BL, Mac Donald CL, Keene CD. PMID: 36399262.
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Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change. Acta Neuropathol. 2023 03; 145(3):303-324. Scaduto P, Lauterborn JC, Cox CD, Fracassi A, Zeppillo T, Gutierrez BA, Keene CD, Crane PK, Mukherjee S, Russell WK, Taglialatela G, Limon A. PMID: 36538112; PMCID: PMC9925531.
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LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2023 02; 145(2):159-173. Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tomé SO, Troncoso JC, Wang SJ, White CL, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. PMID: 36512061; PMCID: PMC9849315.
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SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. Proc Natl Acad Sci U S A. 2022 12 13; 119(50):e2213157119. Shea D, Colasurdo E, Smith A, Paschall C, Jayadev S, Keene CD, Galasko D, Ko A, Li G, Peskind E, Daggett V. PMID: 36490316; PMCID: PMC9897489.
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Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2212954119. Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. PMID: 36343257; PMCID: PMC9674250.
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A single-cell based precision medicine approach using glioblastoma patient-specific models. NPJ Precis Oncol. 2022 Aug 08; 6(1):55. Park JH, Feroze AH, Emerson SN, Mihalas AB, Keene CD, Cimino PJ, de Lomana ALG, Kannan K, Wu WJ, Turkarslan S, Baliga NS, Patel AP. PMID: 35941215; PMCID: PMC9360428.
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Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathol. 2022 07; 144(1):27-44. Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J, Dickson DW, Dugger BN, Ervin JF, Fleming J, Graff-Radford J, Grinberg LT, Hokkanen SRK, Hunter S, Kapasi A, Kawas CH, Keage HAD, Keene CD, Kero M, Knopman DS, Kouri N, Kovacs GG, Labuzan SA, Larson EB, Latimer CS, Leite REP, Matchett BJ, Matthews FE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Nelson RS, Neltner JH, Nguyen AT, Petersen RC, Polvikoski T, Reichard RR, Rodriguez RD, Suemoto CK, Wang SJ, Wharton SB, White L, Schneider JA. PMID: 35697880; PMCID: PMC9552938.
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Cis- and trans-resveratrol have opposite effects on histone serine-ADP-ribosylation and tyrosine induced neurodegeneration. Nat Commun. 2022 06 10; 13(1):3244. Jhanji M, Rao CN, Massey JC, Hope MC, Zhou X, Keene CD, Ma T, Wyatt MD, Stewart JA, Sajish M. PMID: 35688816; PMCID: PMC9187644.
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Association of cerebral microvascular dysfunction and white matter injury in Alzheimer's disease. Geroscience. 2022 08; 44(4):1-14. Bagi Z, Kroenke CD, Fopiano KA, Tian Y, Filosa JA, Sherman LS, Larson EB, Keene CD, Degener O'Brien K, Adeniyi PA, Back SA. PMID: 35612774; PMCID: PMC9617002.
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Detection of astrocytic tau pathology facilitates recognition of chronic traumatic encephalopathy neuropathologic change. Acta Neuropathol Commun. 2022 04 11; 10(1):50. Ameen-Ali KE, Bretzin A, Lee EB, Folkerth R, Hazrati LN, Iacono D, Keene CD, Kofler J, Kovacs GG, Nolan A, Perl DP, Priemer DS, Smith DH, Wiebe DJ, Stewart W, CONNECT-TBI Investigators. PMID: 35410438; PMCID: PMC8996534.
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TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans. Dis Model Mech. 2022 04 01; 15(4). Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, Kraemer BC, Liachko NF. PMID: 35178571; PMCID: PMC9066518.
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Local connectivity and synaptic dynamics in mouse and human neocortex. Science. 2022 03 11; 375(6585):eabj5861. Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T. PMID: 35271334; PMCID: PMC9970277.
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Author Correction: Human neocortical expansion involves glutamatergic neuron diversification. Nature. 2022 Jan; 601(7893):E12. Berg J, Sorensen SA, Ting JT, Miller JA, Chartrand T, Buchin A, Bakken TE, Budzillo A, Dee N, Ding SL, Gouwens NW, Hodge RD, Kalmbach B, Lee C, Lee BR, Alfiler L, Baker K, Barkan E, Beller A, Berry K, Bertagnolli D, Bickley K, Bomben J, Braun T, Brouner K, Casper T, Chong P, Crichton K, Dalley R, de Frates R, Desta T, Lee SD, D'Orazi F, Dotson N, Egdorf T, Enstrom R, Farrell C, Feng D, Fong O, Furdan S, Galakhova AA, Gamlin C, Gary A, Glandon A, Goldy J, Gorham M, Goriounova NA, Gratiy S, Graybuck L, Gu H, Hadley K, Hansen N, Heistek TS, Henry AM, Heyer DB, Hill D, Hill C, Hupp M, Jarsky T, Kebede S, Keene L, Kim L, Kim MH, Kroll M, Latimer C, Levi BP, Link KE, Mallory M, Mann R, Marshall D, Maxwell M, McGraw M, McMillen D, Melief E, Mertens EJ, Mezei L, Mihut N, Mok S, Molnar G, Mukora A, Ng L, Ngo K, Nicovich PR, Nyhus J, Olah G, Oldre A, Omstead V, Ozsvar A, Park D, Peng H, Pham T, Pom CA, Potekhina L, Rajanbabu R, Ransford S, Reid D, Rimorin C, Ruiz A, Sandman D, Sulc J, Sunkin SM, Szafer A, Szemenyei V, Thomsen ER, Tieu M, Torkelson A, Trinh J, Tung H, Wakeman W, Waleboer F, Ward K, Wilbers R, Williams G, Yao Z, Yoon JG, Anastassiou C, Arkhipov A, Barzo P, Bernard A, Cobbs C, de Witt Hamer PC, Ellenbogen RG, Esposito L, Ferreira M, Gwinn RP, Hawrylycz MJ, Hof PR, Idema S, Jones AR, Keene CD, Ko AL, Murphy GJ, Ng L, Ojemann JG, Patel AP, Phillips JW, Silbergeld DL, Smith K, Tasic B, Yuste R, Segev I, de Kock CPJ, Mansvelder HD, Tamas G, Zeng H, Koch C, Lein ES. PMID: 34992294; PMCID: PMC8770134.
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Multispectral LEDs Eliminate Lipofuscin-Associated Autofluorescence for Immunohistochemistry and CD44 Variant Detection by in Situ Hybridization in Aging Human, non-Human Primate, and Murine Brain. ASN Neuro. 2022 Jan-Dec; 14:17590914221123138. Adeniyi PA, Fopiano KA, Banine F, Garcia M, Gong X, Keene CD, Sherman LS, Bagi Z, Back SA. PMID: 36164936; PMCID: PMC9520168.
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Mass Synaptometry: Applying Mass Cytometry to Single Synapse Analysis. Methods Mol Biol. 2022; 2417:69-88. Gajera CR, Fernandez R, Postupna N, Montine KS, Keene CD, Bendall SC, Montine TJ. PMID: 35099792; PMCID: PMC8820390.
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Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Sci Adv. 2021 Dec 17; 7(51):eabk0473. Phongpreecha T, Gajera CR, Liu CC, Vijayaragavan K, Chang AL, Becker M, Fallahzadeh R, Fernandez R, Postupna N, Sherfield E, Tebaykin D, Latimer C, Shively CA, Register TC, Craft S, Montine KS, Fox EJ, Poston KL, Keene CD, Angelo M, Bendall SC, Aghaeepour N, Montine TJ. PMID: 34910503; PMCID: PMC8673771.
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Prostate Cancer Risk Stratification via Nondestructive 3D Pathology with Deep Learning-Assisted Gland Analysis. Cancer Res. 2022 01 15; 82(2):334-345. Xie W, Reder NP, Koyuncu C, Leo P, Hawley S, Huang H, Mao C, Postupna N, Kang S, Serafin R, Gao G, Han Q, Bishop KW, Barner LA, Fu P, Wright JL, Keene CD, Vaughan JC, Janowczyk A, Glaser AK, Madabhushi A, True LD, Liu JTC. PMID: 34853071; PMCID: PMC8803395.
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Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. JAMA Netw Open. 2021 12 01; 4(12):e2140191. Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, TRACK-TBI Investigators, Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. PMID: 34964854; PMCID: PMC8717106.
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Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease. J Proteome Res. 2022 01 07; 21(1):118-131. Hubbard EE, Heil LR, Merrihew GE, Chhatwal JP, Farlow MR, McLean CA, Ghetti B, Newell KL, Frosch MP, Bateman RJ, Larson EB, Keene CD, Perrin RJ, Montine TJ, MacCoss MJ, Julian RR. PMID: 34818016; PMCID: PMC8741752.
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Viable human brain microvessels for the study of aging and neurodegenerative diseases. Microvasc Res. 2022 03; 140:104282. Damodarasamy M, Khaing ZZ, Hyde J, Keene CD, Bentov I, Banks WA, Reed MJ. PMID: 34813858; PMCID: PMC8846932.
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Spinal cord-predominant neuropathology in an adult-onset case of POLR3A-related spastic ataxia. Neuropathology. 2022 Feb; 42(1):58-65. Sytsma TM, Chen DH, Rolf B, Dorschner M, Jayadev S, Keene CD, Zhang J, Bird TD, Latimer CS. PMID: 34753215; PMCID: PMC8810698.
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Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathol. 2022 01; 143(1):33-53. Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF. PMID: 34719765; PMCID: PMC8786260.
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Comparative cellular analysis of motor cortex in human, marmoset and mouse. Nature. 2021 10; 598(7879):111-119. Bakken TE, Jorstad NL, Hu Q, Lake BB, Tian W, Kalmbach BE, Crow M, Hodge RD, Krienen FM, Sorensen SA, Eggermont J, Yao Z, Aevermann BD, Aldridge AI, Bartlett A, Bertagnolli D, Casper T, Castanon RG, Crichton K, Daigle TL, Dalley R, Dee N, Dembrow N, Diep D, Ding SL, Dong W, Fang R, Fischer S, Goldman M, Goldy J, Graybuck LT, Herb BR, Hou X, Kancherla J, Kroll M, Lathia K, van Lew B, Li YE, Liu CS, Liu H, Lucero JD, Mahurkar A, McMillen D, Miller JA, Moussa M, Nery JR, Nicovich PR, Niu SY, Orvis J, Osteen JK, Owen S, Palmer CR, Pham T, Plongthongkum N, Poirion O, Reed NM, Rimorin C, Rivkin A, Romanow WJ, Sedeño-Cortés AE, Siletti K, Somasundaram S, Sulc J, Tieu M, Torkelson A, Tung H, Wang X, Xie F, Yanny AM, Zhang R, Ament SA, Behrens MM, Bravo HC, Chun J, Dobin A, Gillis J, Hertzano R, Hof PR, Höllt T, Horwitz GD, Keene CD, Kharchenko PV, Ko AL, Lelieveldt BP, Luo C, Mukamel EA, Pinto-Duarte A, Preissl S, Regev A, Ren B, Scheuermann RH, Smith K, Spain WJ, White OR, Koch C, Hawrylycz M, Tasic B, Macosko EZ, McCarroll SA, Ting JT, Zeng H, Zhang K, Feng G, Ecker JR, Linnarsson S, Lein ES. PMID: 34616062; PMCID: PMC8494640.
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Human neocortical expansion involves glutamatergic neuron diversification. Nature. 2021 10; 598(7879):151-158. Berg J, Sorensen SA, Ting JT, Miller JA, Chartrand T, Buchin A, Bakken TE, Budzillo A, Dee N, Ding SL, Gouwens NW, Hodge RD, Kalmbach B, Lee C, Lee BR, Alfiler L, Baker K, Barkan E, Beller A, Berry K, Bertagnolli D, Bickley K, Bomben J, Braun T, Brouner K, Casper T, Chong P, Crichton K, Dalley R, de Frates R, Desta T, Lee SD, D'Orazi F, Dotson N, Egdorf T, Enstrom R, Farrell C, Feng D, Fong O, Furdan S, Galakhova AA, Gamlin C, Gary A, Glandon A, Goldy J, Gorham M, Goriounova NA, Gratiy S, Graybuck L, Gu H, Hadley K, Hansen N, Heistek TS, Henry AM, Heyer DB, Hill D, Hill C, Hupp M, Jarsky T, Kebede S, Keene L, Kim L, Kim MH, Kroll M, Latimer C, Levi BP, Link KE, Mallory M, Mann R, Marshall D, Maxwell M, McGraw M, McMillen D, Melief E, Mertens EJ, Mezei L, Mihut N, Mok S, Molnar G, Mukora A, Ng L, Ngo K, Nicovich PR, Nyhus J, Olah G, Oldre A, Omstead V, Ozsvar A, Park D, Peng H, Pham T, Pom CA, Potekhina L, Rajanbabu R, Ransford S, Reid D, Rimorin C, Ruiz A, Sandman D, Sulc J, Sunkin SM, Szafer A, Szemenyei V, Thomsen ER, Tieu M, Torkelson A, Trinh J, Tung H, Wakeman W, Waleboer F, Ward K, Wilbers R, Williams G, Yao Z, Yoon JG, Anastassiou C, Arkhipov A, Barzo P, Bernard A, Cobbs C, de Witt Hamer PC, Ellenbogen RG, Esposito L, Ferreira M, Gwinn RP, Hawrylycz MJ, Hof PR, Idema S, Jones AR, Keene CD, Ko AL, Murphy GJ, Ng L, Ojemann JG, Patel AP, Phillips JW, Silbergeld DL, Smith K, Tasic B, Yuste R, Segev I, de Kock CPJ, Mansvelder HD, Tamas G, Zeng H, Koch C, Lein ES. PMID: 34616067; PMCID: PMC8494638.
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Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons. Neuron. 2021 09 15; 109(18):2914-2927.e5. Kalmbach BE, Hodge RD, Jorstad NL, Owen S, de Frates R, Yanny AM, Dalley R, Mallory M, Graybuck LT, Radaelli C, Keene CD, Gwinn RP, Silbergeld DL, Cobbs C, Ojemann JG, Ko AL, Patel AP, Ellenbogen RG, Bakken TE, Daigle TL, Dee N, Lee BR, McGraw M, Nicovich PR, Smith K, Sorensen SA, Tasic B, Zeng H, Koch C, Lein ES, Ting JT. PMID: 34534454; PMCID: PMC8570452.
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Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain. Alzheimers Dement. 2022 05; 18(5):942-954. Logsdon AF, Francis KL, Richardson NE, Hu SJ, Faber CL, Phan BA, Nguyen V, Setthavongsack N, Banks WA, Woltjer RL, Keene CD, Latimer CS, Schwartz MW, Scarlett JM, Alonge KM. PMID: 34482642; PMCID: PMC8897514.
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Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA Neurol. 2021 09 01; 78(9):1137-1148. Yuh EL, Jain S, Sun X, Pisica D, Harris MH, Taylor SR, Markowitz AJ, Mukherjee P, Verheyden J, Giacino JT, Levin HS, McCrea M, Stein MB, Temkin NR, Diaz-Arrastia R, Robertson CS, Lingsma HF, Okonkwo DO, Maas AIR, Manley GT, TRACK-TBI Investigators for the CENTER-TBI Investigators, Adeoye O, Badjatia N, Boase K, Bodien Y, Corrigan JD, Crawford K, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Keene CD, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Nelson L, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Toga A, Valadka A, Vassar M, Zafonte R. PMID: 34279565; PMCID: PMC8290344.
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Leveraging Neuroimaging Tools to Assess Precision and Accuracy in an Alzheimer's Disease Neuropathologic Sampling Protocol. Front Neurosci. 2021; 15:693242. Webster JM, Grabowski TJ, Madhyastha TM, Gibbons LE, Keene CD, Latimer CS. PMID: 34483821; PMCID: PMC8416420.
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Isoform-specific dysregulation of AMP-activated protein kinase signaling in a non-human primate model of Alzheimer's disease. Neurobiol Dis. 2021 10; 158:105463. Wang X, Zhou X, Uberseder B, Lee J, Latimer CS, Furdui CM, Keene CD, Montine TJ, Register TC, Craft S, Shively CA, Ma T. PMID: 34363967; PMCID: PMC8440492.
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Functional Outcomes Over the First Year After Moderate to Severe Traumatic Brain Injury in the Prospective, Longitudinal TRACK-TBI Study. JAMA Neurol. 2021 08 01; 78(8):982-992. McCrea MA, Giacino JT, Barber J, Temkin NR, Nelson LD, Levin HS, Dikmen S, Stein M, Bodien YG, Boase K, Taylor SR, Vassar M, Mukherjee P, Robertson C, Diaz-Arrastia R, Okonkwo DO, Markowitz AJ, Manley GT, TRACK-TBI Investigators, Adeoye O, Badjatia N, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Goldman D, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Ngwenya LB, Noel F, Nolan A, Palacios E, Perl D, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sherer M, Toga A, Valadka A, Wang K, Yue JK, Yuh E, Zafonte R. PMID: 34228047; PMCID: PMC8261688.
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Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta Neuropathol Commun. 2021 06 29; 9(1):117. McMillan PJ, Strovas TJ, Baum M, Mitchell BK, Eck RJ, Hendricks N, Wheeler JM, Latimer CS, Keene CD, Kraemer BC. PMID: 34187600; PMCID: PMC8243890.
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Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis. Proc Natl Acad Sci U S A. 2021 06 22; 118(25). Wu Z, Chen C, Kang SS, Liu X, Gu X, Yu SP, Keene CD, Cheng L, Ye K. PMID: 34140411; PMCID: PMC8237621.
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Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Biol Psychiatry. 2022 03 01; 91(5):498-507. Brett BL, Gardner RC, Godbout J, Dams-O'Connor K, Keene CD. PMID: 34364650; PMCID: PMC8636548.
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Application of deep learning to understand resilience to Alzheimer's disease pathology. Brain Pathol. 2021 11; 31(6):e12974. Lee CS, Latimer CS, Henriksen JC, Blazes M, Larson EB, Crane PK, Keene CD, Lee AY. PMID: 34009663; PMCID: PMC8549025.
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Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease. Nat Commun. 2021 05 10; 12(1):2603. Lauterborn JC, Scaduto P, Cox CD, Schulmann A, Lynch G, Gall CM, Keene CD, Limon A. PMID: 33972518; PMCID: PMC8110554.
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Theoretical impact of the AT(N) framework on dementia using a community autopsy sample. Alzheimers Dement. 2021 12; 17(12):1879-1891. Burke BT, Latimer C, Keene CD, Sonnen JA, McCormick W, Bowen JD, McCurry SM, Larson EB, Crane PK. PMID: 33900044; PMCID: PMC8875276.
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Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression. Nat Biotechnol. 2021 07; 39(7):819-824. Wu SJ, Furlan SN, Mihalas AB, Kaya-Okur HS, Feroze AH, Emerson SN, Zheng Y, Carson K, Cimino PJ, Keene CD, Sarthy JF, Gottardo R, Ahmad K, Henikoff S, Patel AP. PMID: 33846646; PMCID: PMC8277750.
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Aging-related Alzheimer's disease-like neuropathology and functional decline in captive vervet monkeys (Chlorocebus aethiops sabaeus). Am J Primatol. 2021 11; 83(11):e23260. Frye BM, Craft S, Latimer CS, Keene CD, Montine TJ, Register TC, Orr ME, Kavanagh K, Macauley SL, Shively CA. PMID: 33818801; PMCID: PMC8626867.
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Mass-tag barcoding for multiplexed analysis of human synaptosomes and other anuclear events. Cytometry A. 2021 09; 99(9):939-945. Gajera CR, Fernandez R, Montine KS, Fox EJ, Mrdjen D, Postupna NO, Keene CD, Bendall SC, Montine TJ. PMID: 33818911; PMCID: PMC8590852.
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Association of Sex and Age With Mild Traumatic Brain Injury-Related Symptoms: A TRACK-TBI Study. JAMA Netw Open. 2021 04 01; 4(4):e213046. Levin HS, Temkin NR, Barber J, Nelson LD, Robertson C, Brennan J, Stein MB, Yue JK, Giacino JT, McCrea MA, Diaz-Arrastia R, Mukherjee P, Okonkwo DO, Boase K, Markowitz AJ, Bodien Y, Taylor S, Vassar MJ, Manley GT, TRACK-TBI Investigators, Adeoye O, Badjatia N, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Nolan A, Ngwenya LB, Noel F, Palacios E, Puccio A, Rabinowitz M, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Sun X, Toga A, Valadka A, Wang K, Yuh E, Zafonte R. PMID: 33822070; PMCID: PMC8025125.
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Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex. Cell Rep. 2021 03 30; 34(13):108754. Mich JK, Graybuck LT, Hess EE, Mahoney JT, Kojima Y, Ding Y, Somasundaram S, Miller JA, Kalmbach BE, Radaelli C, Gore BB, Weed N, Omstead V, Bishaw Y, Shapovalova NV, Martinez RA, Fong O, Yao S, Mortrud M, Chong P, Loftus L, Bertagnolli D, Goldy J, Casper T, Dee N, Opitz-Araya X, Cetin A, Smith KA, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Keene CD, Silbergeld DL, Sunkin SM, Gradinaru V, Horwitz GD, Zeng H, Tasic B, Lein ES, Ting JT, Levi BP. PMID: 33789096; PMCID: PMC8163032.
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The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample. Front Neurol. 2021; 12:624696. Postupna N, Rose SE, Gibbons LE, Coleman NM, Hellstern LL, Ritchie K, Wilson AM, Cudaback E, Li X, Melief EJ, Beller AE, Miller JA, Nolan AL, Marshall DA, Walker R, Montine TJ, Larson EB, Crane PK, Ellenbogen RG, Lein ES, Dams-O'Connor K, Keene CD. PMID: 33796061; PMCID: PMC8008107.
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COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI). Acta Neuropathol Commun. 2021 03 01; 9(1):32. Smith DH, Dollé JP, Ameen-Ali KE, Bretzin A, Cortes E, Crary JF, Dams-O'Connor K, Diaz-Arrastia R, Edlow BL, Folkerth R, Hazrati LN, Hinds SR, Iacono D, Johnson VE, Keene CD, Kofler J, Kovacs GG, Lee EB, Manley G, Meaney D, Montine T, Okonkwo DO, Perl DP, Trojanowski JQ, Wiebe DJ, Yaffe K, McCabe T, Stewart W. PMID: 33648593; PMCID: PMC7919306.
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Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury: Findings From the TRACK-TBI Study. JAMA Netw Open. 2021 03 01; 4(3):e213467. Brett BL, Kramer MD, Whyte J, McCrea MA, Stein MB, Giacino JT, Sherer M, Markowitz AJ, Manley GT, Nelson LD, TRACK-TBI Investigators, Adeoye O, Badjatia N, Boase K, Barber J, Bodien Y, Bullock MR, Chesnut R, Corrigan JD, Crawford K, Diaz-Arrastia R, Dikmen S, Duhaime AC, Ellenbogen R, Feeser VR, Ferguson AR, Foreman B, Gardner R, Gaudette E, Gonzalez L, Gopinath S, Gullapalli R, Hemphill JC, Hotz G, Jain S, Keene CD, Korley FK, Kramer J, Kreitzer N, Levin H, Lindsell C, Machamer J, Madden C, Martin A, McAllister T, Merchant R, Mukherjee P, Ngwenya LB, Noel F, Okonkwo D, Palacios E, Puccio A, Rabinowitz M, Robertson C, Rosand J, Sander A, Satris G, Schnyer D, Seabury S, Taylor S, Temkin N, Toga A, Valadka A, Vassar M, Wang K, Yue JK, Yuh E, Zafonte R. PMID: 33783518; PMCID: PMC8010589.
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The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol. 2021 02 22; 80(3):210-219. Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Dams-O'Connor K, Gordon WA, Tripodis Y, Alvarez VE, Mez J, Alosco ML, McKee AC, TBI/CTE Research Group. PMID: 33611507; PMCID: PMC7899277.
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Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study. J Neurotrauma. 2021 06 15; 38(12):1620-1631. Nolan AL, Petersen C, Iacono D, Mac Donald CL, Mukherjee P, van der Kouwe A, Jain S, Stevens A, Diamond BR, Wang R, Markowitz AJ, Fischl B, Perl DP, Manley GT, Keene CD, Diaz-Arrastia R, Edlow BL, TRACK-TBI Investigators. PMID: 33412995; PMCID: PMC8165468.
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Genetic Insights into Alzheimer's Disease. Annu Rev Pathol. 2021 01 24; 16:351-376. Latimer CS, Lucot KL, Keene CD, Cholerton B, Montine TJ. PMID: 33497263; PMCID: PMC8664069.
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Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol. 2021 01 20; 80(2):102-111. Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, Fischer P, Flanagan ME, Franklin E, Gearing M, Glass J, Hansen LA, Haroutunian V, Hof PR, Honig L, Kawas C, Keene CD, Kofler J, Kovacs GG, Lee EB, Lutz MI, Mao Q, Masliah E, McKee AC, McMillan CT, Mesulam MM, Murray M, Nelson PT, Perrin R, Pham T, Poon W, Purohit DP, Rissman RA, Sakai K, Sano M, Schneider JA, Stein TD, Teich AF, Trojanowski JQ, Troncoso JC, Vonsattel JP, Weintraub S, Wolk DA, Woltjer RL, Yamada M, Yu L, White CL, Crary JF. PMID: 33367843; PMCID: PMC8453611.
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Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146. Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, Montine TJ, Morgello S, Phelps C, Safar J, Schneider JA, Schonberger LB, Sigurdson C, Silverberg N, Trojanowski JQ, Frosch MP. PMID: 33000167; PMCID: PMC7577514.
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Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiol Dis. 2021 01; 147:105148. Kow RL, Strovas TJ, McMillan PJ, Jacobi AM, Behlke MA, Saxton AD, Latimer CS, Keene CD, Kraemer BC. PMID: 33184027; PMCID: PMC8092974.
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The microvascular extracellular matrix in brains with Alzheimer's disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA). Fluids Barriers CNS. 2020 Sep 29; 17(1):60. Damodarasamy M, Vernon RB, Pathan JL, Keene CD, Day AJ, Banks WA, Reed MJ. PMID: 32993718; PMCID: PMC7525948.
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Clinician-judged hearing impairment and associations with neuropathologic burden. Neurology. 2020 09 22; 95(12):e1640-e1649. Brenowitz WD, Besser LM, Kukull WA, Keene CD, Glymour MM, Yaffe K. PMID: 32759190; PMCID: PMC7713726.
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Chronic elevation of plasma vascular endothelial growth factor-A (VEGF-A) is associated with a history of blast exposure. J Neurol Sci. 2020 Oct 15; 417:117049. Meabon JS, Cook DG, Yagi M, Terry GE, Cross DJ, Muzi M, Pagulayan KF, Logsdon AF, Schindler AG, Ghai V, Wang K, Fallen S, Zhou Y, Kim TK, Lee I, Banks WA, Carlson ES, Mayer C, Hendrickson RC, Raskind MA, Marshall DA, Perl DP, Keene CD, Peskind ER. PMID: 32758764; PMCID: PMC7492467.
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Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice. J Clin Invest. 2020 07 01; 130(7):3511-3527. Zimmermann HR, Yang W, Kasica NP, Zhou X, Wang X, Beckelman BC, Lee J, Furdui CM, Keene CD, Ma T. PMID: 32213711; PMCID: PMC7324210.
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Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study. EJNMMI Res. 2020 Jun 15; 10(1):65. Pontecorvo MJ, Keene CD, Beach TG, Montine TJ, Arora AK, Devous MD, Navitsky M, Kennedy I, Joshi AD, Lu M, Serrano GE, Sue LI, Intorcia AJ, Rose SE, Wilson A, Hellstern L, Coleman N, Flitter M, Aldea P, Fleisher AS, Mintun MA, Siderowf A. PMID: 32542468; PMCID: PMC7295920.
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Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury. Sci Rep. 2020 06 10; 10(1):9420. Logsdon AF, Schindler AG, Meabon JS, Yagi M, Herbert MJ, Banks WA, Raskind MA, Marshall DA, Keene CD, Perl DP, Peskind ER, Cook DG. PMID: 32523011; PMCID: PMC7287110.
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Concordance of Clinical Alzheimer Diagnosis and Neuropathological Features at Autopsy. J Neuropathol Exp Neurol. 2020 05 01; 79(5):465-473. Gauthreaux K, Bonnett TA, Besser LM, Brenowitz WD, Teylan M, Mock C, Chen YC, Chan KCG, Keene CD, Zhou XH, Kukull WA. PMID: 32186726; PMCID: PMC7160616.
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The application of in vitro-derived human neurons in neurodegenerative disease modeling. J Neurosci Res. 2021 01; 99(1):124-140. D'Souza GX, Rose SE, Knupp A, Nicholson DA, Keene CD, Young JE. PMID: 32170790; PMCID: PMC7487003.
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Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667. Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Keene CD, Kamboh MI, Kofler JK, Duque L, Gilbert JR, Gwirtsman HE, Buxbaum JD, Dickson DW, Frosch MP, Ghetti BF, Lunetta KL, Wang LS, Hyman BT, Kukull WA, Foroud T, Haines JL, Mayeux RP, Pericak-Vance MA, Schneider JA, Trojanowski JQ, Farrer LA, Schellenberg GD, Beecham GW, Montine TJ, Jun GR, Alzheimer’s Disease Genetics Consortium. PMID: 32015339; PMCID: PMC6997393.
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Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease. PLoS One. 2020; 15(1):e0227667. Lee EG, Tulloch J, Chen S, Leong L, Saxton AD, Kraemer B, Darvas M, Keene CD, Shutes-David A, Todd K, Millard S, Yu CE. PMID: 31978088; PMCID: PMC6980611.
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Maximizing Safety in the Conduct of Alzheimer's Disease Fluid Biomarker Research in the Era of COVID-19. J Alzheimers Dis. 2020; 76(1):27-31. Schindler SE, Jicha GA, Nelson PT, Keene CD, Blennow K, Molinuevo JL, Masters CL, Hansson O, Teunissen CE, Galasko D, Shaw LM, Levey AI, Silverberg N. PMID: 32568212; PMCID: PMC7995336.
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Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Sci Transl Med. 2019 12 18; 11(523). Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, Lee VMY, Wang LS, Keene CD, Bird T, Schellenberg GD, Kraemer B. PMID: 31852801; PMCID: PMC7311111.
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Genome wide analysis reveals heparan sulfate epimerase modulates TDP-43 proteinopathy. PLoS Genet. 2019 12; 15(12):e1008526. Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Keene CD, Bird TD, Kraemer BC. PMID: 31834878; PMCID: PMC6934317.
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Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma. Brain. 2019 Dec 01; 142(12):3672-3693. Iverson GL, Gardner AJ, Shultz SR, Solomon GS, McCrory P, Zafonte R, Perry G, Hazrati LN, Keene CD, Castellani RJ. PMID: 31670780; PMCID: PMC6906593.
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Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. Prog Neurobiol. 2020 02; 185:101730. Wu Z, Wang ZH, Liu X, Zhang Z, Gu X, Yu SP, Keene CD, Cheng L, Ye K. PMID: 31778772.
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Quantitative analysis of chondroitin sulfate disaccharides from human and rodent fixed brain tissue by electrospray ionization-tandem mass spectrometry. Glycobiology. 2019 11 20; 29(12):847-860. Alonge KM, Logsdon AF, Murphree TA, Banks WA, Keene CD, Edgar JS, Whittington D, Schwartz MW, Guttman M. PMID: 31361007; PMCID: PMC6861844.
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Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma. J Neuropathol Exp Neurol. 2019 11 01; 78(11):1002-1010. Yoda RA, Marxen T, Longo L, Ene C, Wirsching HG, Keene CD, Holland EC, Cimino PJ. PMID: 31529048.
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Targeted Quantitative Proteomic Approach for High-Throughput Quantitative Profiling of Small GTPases in Brain Tissues of Alzheimer's Disease Patients. Anal Chem. 2019 10 01; 91(19):12307-12314. Huang M, Darvas M, Keene CD, Wang Y. PMID: 31460748; PMCID: PMC6939614.
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Cross species application of quantitative neuropathology assays developed for clinical Alzheimer's disease samples. Pathobiol Aging Age Relat Dis. 2019; 9(1):1657768. Urfer SR, Latimer CS, Ladiges W, Keene CD, Benbow S, Harrison B, Promislow DEL, Kaeberlein M, Kraemer BC, Wang A, Guscetti F, Darvas M. PMID: 31528297; PMCID: PMC6735310.
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Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Uitterlinden AGA, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, et al. PMID: 31417202; PMCID: PMC7265117.
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Sex differences in the genetic predictors of Alzheimer's pathology. Brain. 2019 09 01; 142(9):2581-2589. Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Deming Y, Chao MJ, Huentelman M, Martin ER, Hamilton-Nelson K, Shaw LM, Trojanowski JQ, Peskind ER, Cruchaga C, Pericak-Vance MA, Goate AM, Cox NJ, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative, Bennett DA, Schneider JA, Jefferson AL, Hohman TJ. PMID: 31497858; PMCID: PMC6736148.
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Reply: LATE to the PART-y. Brain. 2019 09 01; 142(9):e48. Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Fardo DW, Flanagan ME, Halliday G, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murray ME, Nag S, Seeley WW, Sperling RA, White CL, Schneider JA. PMID: 31359039; PMCID: PMC6931389.
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A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease. Acta Neuropathol Commun. 2019 07 30; 7(1):124. Smith BR, Nelson KM, Kemper LJ, Leinonen-Wright K, Petersen A, Keene CD, Ashe KH. PMID: 31362787; PMCID: PMC6668119.
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Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta Neuropathol Commun. 2019 06 07; 7(1):91. Latimer CS, Burke BT, Liachko NF, Currey HN, Kilgore MD, Gibbons LE, Henriksen J, Darvas M, Domoto-Reilly K, Jayadev S, Grabowski TJ, Crane PK, Larson EB, Kraemer BC, Bird TD, Keene CD. PMID: 31174609; PMCID: PMC6556006.
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Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain. 2019 06 01; 142(6):1503-1527. Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, Hokkanen SRK, Hunter S, Jicha GA, Katsumata Y, Kawas CH, Keene CD, Kovacs GG, Kukull WA, Levey AI, Makkinejad N, Montine TJ, Murayama S, Murray ME, Nag S, Rissman RA, Seeley WW, Sperling RA, White CL, Yu L, Schneider JA. PMID: 31039256; PMCID: PMC6536849.
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Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Sci Transl Med. 2019 05 01; 11(490). Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB. PMID: 31043574; PMCID: PMC6640844.
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Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia. Am J Hum Genet. 2019 05 02; 104(5):936-947. Oosterhof N, Chang IJ, Karimiani EG, Kuil LE, Jensen DM, Daza R, Young E, Astle L, van der Linde HC, Shivaram GM, Demmers J, Latimer CS, Keene CD, Loter E, Maroofian R, van Ham TJ, Hevner RF, Bennett JT. PMID: 30982608; PMCID: PMC6506793.
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Alternative splicing in a presenilin 2 variant associated with Alzheimer disease. Ann Clin Transl Neurol. 2019 Apr; 6(4):762-777. Braggin JE, Bucks SA, Course MM, Smith CL, Sopher B, Osnis L, Shuey KD, Domoto-Reilly K, Caso C, Kinoshita C, Scherpelz KP, Cross C, Grabowski T, Nik SHM, Newman M, Garden GA, Leverenz JB, Tsuang D, Latimer C, Gonzalez-Cuyar LF, Keene CD, Morrison RS, Rhoads K, Wijsman EM, Dorschner MO, Lardelli M, Young JE, Valdmanis PN, Bird TD, Jayadev S. PMID: 31020001; PMCID: PMC6469258.
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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430. Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujic-Comic H, Frosch MP, Thonberg H, Maier W, Roshchupkin G, Ghetti B, Giedraitis V, Kawalia A, Li S, Huebinger RM, Kilander L, Moebus S, Hernández I, Kamboh MI, Brundin R, Turton J, Yang Q, Katz MJ, Concari L, Lord J, Beiser AS, Keene CD, Helisalmi S, Kloszewska I, Kukull WA, Koivisto AM, Lynch A, Tarraga L, Larson EB, Haapasalo A, Lawlor B, Mosley TH, Lipton RB, Solfrizzi V, Gill M, Longstreth WT, Montine TJ, Frisardi V, Diez-Fairen M, Rivadeneira F, Petersen RC, Deramecourt V, Alvarez I, Salani F, Ciaramella A, Boerwinkle E, Reiman EM, Fievet N, Rotter JI, Reisch JS, Hanon O, Cupidi C, Andre Uitterlinden AG, Royall DR, Dufouil C, Maletta RG, de Rojas I, Sano M, Brice A, Cecchetti R, George-Hyslop PS, Ritchie K, Tsolaki M, Tsuang DW, Dubois B, Craig D, Wu CK, Soininen H, Avramidou D, Albin RL, Fratiglioni L, Germanou A, Apostolova LG, Keller L, Koutroumani M, Arnold SE, Panza F, Gkatzima O, Asthana S, Hannequin D, Whitehead P, Atwood CS, Caffarra P, Hampel H, Quintela I, Carracedo Á, Lannfelt L, Rubinsztein DC, Barnes LL, Pasquier F, Frölich L, Barral S, McGuinness B, Beach TG, Johnston JA, Becker JT, Passmore P, Bigio EH, Schott JM, Bird TD, Warren JD, Boeve BF, Lupton MK, Bowen JD, Proitsi P, Boxer A, Powell JF, Burke JR, Kauwe JSK, Burns JM, Mancuso M, Buxbaum JD, Bonuccelli U, Cairns NJ, McQuillin A, Cao C, Livingston G, Carlson CS, Bass NJ, Carlsson CM, Hardy J, Carney RM, Bras J, Carrasquillo MM, Guerreiro R, Allen M, Chui HC, Fisher E, Masullo C, Crocco EA, DeCarli C, Bisceglio G, Dick M, Ma L, Duara R, Graff-Radford NR, Evans DA, Hodges A, Faber KM, Scherer M, Fallon KB, Riemenschneider M, Fardo DW, Heun R, Farlow MR, Kölsch H, Ferris S, Leber M, Foroud TM, Heuser I, Galasko DR, Giegling I, Gearing M, Hüll M, Geschwind DH, Gilbert JR, Morris J, Green RC, Mayo K, Growdon JH, Feulner T, Hamilton RL, Harrell LE, Drichel D, Honig LS, Cushion TD, Huentelman MJ, Hollingworth P, Hulette CM, Hyman BT, Marshall R, Jarvik GP, Meggy A, Abner E, Menzies GE, Jin LW, Leonenko G, Real LM, Jun GR, Baldwin CT, Grozeva D, Karydas A, Russo G, Kaye JA, Kim R, Jessen F, Kowall NW, Vellas B, Kramer JH, Vardy E, LaFerla FM, Jöckel KH, Lah JJ, Dichgans M, Leverenz JB, Mann D, Levey AI, Pickering-Brown S, Lieberman AP, Klopp N, Lunetta KL, Wichmann HE, Lyketsos CG, Morgan K, Marson DC, et al. PMID: 30820047; PMCID: PMC6463297.
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Primum non nocere: a call for balance when reporting on CTE. Lancet Neurol. 2019 03; 18(3):231-233. Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH. PMID: 30784550; PMCID: PMC6594011.
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Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice. J Clin Invest. 2019 02 01; 129(2):820-833. Beckelman BC, Yang W, Kasica NP, Zimmermann HR, Zhou X, Keene CD, Ryazanov AG, Ma T. PMID: 30667373; PMCID: PMC6355242.
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Increased Hyaluronan and TSG-6 in Association with Neuropathologic Changes of Alzheimer's Disease. J Alzheimers Dis. 2019; 67(1):91-102. Reed MJ, Damodarasamy M, Pathan JL, Chan CK, Spiekerman C, Wight TN, Banks WA, Day AJ, Vernon RB, Keene CD. PMID: 30507579; PMCID: PMC6398602.
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Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain. J Alzheimers Dis. 2019; 68(3):1071-1083. Aiello Bowles EJ, Crane PK, Walker RL, Chubak J, LaCroix AZ, Anderson ML, Rosenberg D, Keene CD, Larson EB. PMID: 30909217; PMCID: PMC8357030.
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Luminex-based quantification of Alzheimer's disease neuropathologic change in formalin-fixed post-mortem human brain tissue. Lab Invest. 2019 07; 99(7):1056-1067. Keene CD, Wilson AM, Kilgore MD, Bruner LT, Postupna NO, Darvas M. PMID: 30573871; PMCID: PMC6586549.
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Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry. 2020 11; 25(11):2942-2951. Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, EPAD Study Group, Investigators from ACT, Investigators from ROS, Investigators from MAP, Investigators from ADNI, Investigators from the University of Pittsburgh ADRC, Crane PK. PMID: 30514930; PMCID: PMC6548676.
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Mass synaptometry: High-dimensional multi parametric assay for single synapses. J Neurosci Methods. 2019 01 15; 312:73-83. Gajera CR, Fernandez R, Postupna N, Montine KS, Fox EJ, Tebaykin D, Angelo M, Bendall SC, Keene CD, Montine TJ. PMID: 30465796; PMCID: PMC6363340.
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A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis. Alzheimers Dement. 2019 01; 15(1):93-105. Latimer CS, Shively CA, Keene CD, Jorgensen MJ, Andrews RN, Register TC, Montine TJ, Wilson AM, Neth BJ, Mintz A, Maldjian JA, Whitlow CT, Kaplan JR, Craft S. PMID: 30467082; PMCID: PMC6383152.
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h-Channels Contribute to Divergent Intrinsic Membrane Properties of Supragranular Pyramidal Neurons in Human versus Mouse Cerebral Cortex. Neuron. 2018 12 05; 100(5):1194-1208.e5. Kalmbach BE, Buchin A, Long B, Close J, Nandi A, Miller JA, Bakken TE, Hodge RD, Chong P, de Frates R, Dai K, Maltzer Z, Nicovich PR, Keene CD, Silbergeld DL, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Koch C, Anastassiou CA, Lein ES, Ting JT. PMID: 30392798; PMCID: PMC6447369.
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Modeling Alzheimer's disease in progeria mice. An age-related concept. Pathobiol Aging Age Relat Dis. 2018; 8(1):1524815. Sharma K, Darvas M, Keene CD, Niedernhofer LJ, Ladiges W. PMID: 30319737; PMCID: PMC6179061.
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Flow cytometric evaluation of crude synaptosome preparation as a way to study synaptic alteration in neurodegenerative diseases. Neuromethods. 2018; 141:297-310. Postupna NO, Latimer CS, Keene CD, Montine KS, Montine TJ, Darvas M. PMID: 32139977; PMCID: PMC7058378.
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Glia-specific APOE epigenetic changes in the Alzheimer's disease brain. Brain Res. 2018 11 01; 1698:179-186. Tulloch J, Leong L, Thomson Z, Chen S, Lee EG, Keene CD, Millard SP, Yu CE. PMID: 30081037; PMCID: PMC6388639.
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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. JAMA Neurol. 2018 08 01; 75(8):989-998. Hohman TJ, Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Bennett DA, Schneider JA, Jefferson AL, Alzheimer’s Disease Genetics Consortium and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 29801024; PMCID: PMC6142927.
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Localized crystal-storing histiocytosis of the posterior fossa. Neuropathology. 2018 Oct; 38(5):529-534. Flanagan ME, Keene CD, Louis DN, Juric-Sekhar G. PMID: 30066398; PMCID: PMC6172157.
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Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathol. 2018 12; 136(6):857-872. Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, Montine TJ, Schellenberg GD, Haines JL, Zetterberg H, Blennow K, Larson EB, Johnson SC, Albert M, Moghekar A, Del Aguila JL, Fernandez MV, Budde J, Hassenstab J, Fagan AM, Riemenschneider M, Petersen RC, Minthon L, Chao MJ, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Peskind ER, Li G, Davis LK, Sealock JM, Cox NJ, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Genetics Consortium (ADGC), Goate AM, Bennett DA, Schneider JA, Jefferson AL, Cruchaga C, Hohman TJ. PMID: 29967939; PMCID: PMC6280657.
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A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits. Sci Rep. 2018 05 30; 8(1):8407. Ting JT, Kalmbach B, Chong P, de Frates R, Keene CD, Gwinn RP, Cobbs C, Ko AL, Ojemann JG, Ellenbogen RG, Koch C, Lein E. PMID: 29849137; PMCID: PMC5976666.
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An anatomic transcriptional atlas of human glioblastoma. Science. 2018 05 11; 360(6389):660-663. Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD. PMID: 29748285; PMCID: PMC6414061.
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Leptomeninges-Derived Induced Pluripotent Stem Cells and Directly Converted Neurons From Autopsy Cases With Varying Neuropathologic Backgrounds. J Neuropathol Exp Neurol. 2018 05 01; 77(5):353-360. Rose SE, Frankowski H, Knupp A, Berry BJ, Martinez R, Dinh SQ, Bruner LT, Willis SL, Crane PK, Larson EB, Grabowski T, Darvas M, Keene CD, Young JE. PMID: 29474672; PMCID: PMC6018913.
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Psychosis in Spinocerebellar Ataxias: a Case Series and Study of Tyrosine Hydroxylase in Substantia Nigra. Cerebellum. 2018 04; 17(2):143-151. Turk KW, Flanagan ME, Josephson S, Keene CD, Jayadev S, Bird TD. PMID: 28887803; PMCID: PMC5843512.
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APOE DNA methylation is altered in Lewy body dementia. Alzheimers Dement. 2018 07; 14(7):889-894. Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, Leverenz JB, Yu CE, Tsuang D. PMID: 29544979; PMCID: PMC6050144.
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Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry. 2018 09 15; 84(6):401-412. Locke TM, Soden ME, Miller SM, Hunker A, Knakal C, Licholai JA, Dhillon KS, Keene CD, Zweifel LS, Carlson ES. PMID: 29478701; PMCID: PMC6072628.
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DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease. J Hum Genet. 2018 Apr; 63(4):459-471. Shao Y, Shaw M, Todd K, Khrestian M, D'Aleo G, Barnard PJ, Zahratka J, Pillai J, Yu CE, Keene CD, Leverenz JB, Bekris LM. PMID: 29371683; PMCID: PMC6466631.
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The Need to Separate Chronic Traumatic Encephalopathy Neuropathology from Clinical Features. J Alzheimers Dis. 2018; 61(1):17-28. Iverson GL, Keene CD, Perry G, Castellani RJ. PMID: 29103039; PMCID: PMC5734127.
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Associations between Use of Specific Analgesics and Concentrations of Amyloid-β 42 or Phospho-Tau in Regions of Human Cerebral Cortex. J Alzheimers Dis. 2018; 61(2):653-662. Flanagan ME, Larson EB, Walker RL, Keene CD, Postupna N, Cholerton B, Sonnen JA, Dublin S, Crane PK, Montine TJ. PMID: 29226863; PMCID: PMC5745256.
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Vasodilator dysfunction and oligodendrocyte dysmaturation in aging white matter. Ann Neurol. 2018 01; 83(1):142-152. Bagi Z, Brandner DD, Le P, McNeal DW, Gong X, Dou H, Fulton DJ, Beller A, Ngyuen T, Larson EB, Montine TJ, Keene CD, Back SA. PMID: 29283444; PMCID: PMC5876126.
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Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis. 2018; 65(2):607-616. Gray SL, Anderson ML, Hanlon JT, Dublin S, Walker RL, Hubbard RA, Yu O, Montine TJ, Crane PK, Sonnen JA, Keene CD, Larson EB. PMID: 30056417; PMCID: PMC6154381.
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First confirmed case of chronic traumatic encephalopathy in a professional bull rider. Acta Neuropathol. 2018 02; 135(2):303-305. Keene CD, Latimer CS, Steele LM, Mac Donald CL. PMID: 29285625; PMCID: PMC5773642.
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Application of the condensed protocol for the NIA-AA guidelines for the neuropathological assessment of Alzheimer's disease in an academic clinical practice. Histopathology. 2018 Feb; 72(3):433-440. Bharadwaj R, Cimino PJ, Flanagan ME, Latimer CS, Gonzalez-Cuyar LF, Juric-Sekhar G, Montine TJ, Marshall DA, Keene CD. PMID: 28815699; PMCID: PMC5771846.
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Neuropathological and transcriptomic characteristics of the aged brain. Elife. 2017 11 09; 6. Miller JA, Guillozet-Bongaarts A, Gibbons LE, Postupna N, Renz A, Beller AE, Sunkin SM, Ng L, Rose SE, Smith KA, Szafer A, Barber C, Bertagnolli D, Bickley K, Brouner K, Caldejon S, Chapin M, Chua ML, Coleman NM, Cudaback E, Cuhaciyan C, Dalley RA, Dee N, Desta T, Dolbeare TA, Dotson NI, Fisher M, Gaudreault N, Gee G, Gilbert TL, Goldy J, Griffin F, Habel C, Haradon Z, Hejazinia N, Hellstern LL, Horvath S, Howard K, Howard R, Johal J, Jorstad NL, Josephsen SR, Kuan CL, Lai F, Lee E, Lee F, Lemon T, Li X, Marshall DA, Melchor J, Mukherjee S, Nyhus J, Pendergraft J, Potekhina L, Rha EY, Rice S, Rosen D, Sapru A, Schantz A, Shen E, Sherfield E, Shi S, Sodt AJ, Thatra N, Tieu M, Wilson AM, Montine TJ, Larson EB, Bernard A, Crane PK, Ellenbogen RG, Keene CD, Lein E. PMID: 29120328; PMCID: PMC5679757.
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Blood-Based Bioenergetic Profiling Reflects Differences in Brain Bioenergetics and Metabolism. Oxid Med Cell Longev. 2017; 2017:7317251. Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Shively C, Andrews RN, Neth B, Keene CD, Mintz A, Craft S, Molina AJA. PMID: 29098063; PMCID: PMC5643153.
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Mixed neuropathologies and associations with domain-specific cognitive decline. Neurology. 2017 Oct 24; 89(17):1773-1781. Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. PMID: 28939667; PMCID: PMC5664309.
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, ARUK Consortium, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, et al. PMID: 28714976; PMCID: PMC5669039.
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Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. Alzheimers Dement. 2017 Dec; 13(12):1307-1316. Crane PK, Trittschuh E, Mukherjee S, Saykin AJ, Sanders RE, Larson EB, McCurry SM, McCormick W, Bowen JD, Grabowski T, Moore M, Bauman J, Gross AL, Keene CD, Bird TD, Gibbons LE, Mez J, Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators. PMID: 28623677; PMCID: PMC5723557.
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Resistance to Alzheimer Disease Neuropathologic Changes and Apparent Cognitive Resilience in the Nun and Honolulu-Asia Aging Studies. J Neuropathol Exp Neurol. 2017 Jun 01; 76(6):458-466. Latimer CS, Keene CD, Flanagan ME, Hemmy LS, Lim KO, White LR, Montine KS, Montine TJ. PMID: 28499012; PMCID: PMC6334750.
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Human Striatal Dopaminergic and Regional Serotonergic Synaptic Degeneration with Lewy Body Disease and Inheritance of APOE ε4. Am J Pathol. 2017 Apr; 187(4):884-895. Postupna N, Latimer CS, Larson EB, Sherfield E, Paladin J, Shively CA, Jorgensen MJ, Andrews RN, Kaplan JR, Crane PK, Montine KS, Craft S, Keene CD, Montine TJ. PMID: 28212814; PMCID: PMC5397713.
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Immunohistochemical profiling including beta-catenin in conjunctival melanocytic lesions. Exp Mol Pathol. 2017 04; 102(2):198-202. Reddy HS, Keene CD, Chang SH, Jian-Amadi A, Cimino PJ. PMID: 28161440.
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Alzheimer's disease neuropathologic change, Lewy body disease, and vascular brain injury in clinic- and community-based samples. Neurobiol Aging. 2017 May; 53:83-92. Brenowitz WD, Keene CD, Hawes SE, Hubbard RA, Longstreth WT, Woltjer RL, Crane PK, Larson EB, Kukull WA. PMID: 28236716; PMCID: PMC5385292.
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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol. 2017 Jan; 16(1):55-65. Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, Leverenz JB, Tsuang D, Longfellow K, Yearout D, Kukull W, Keene CD, Montine TJ, Zabetian CP, Trojanowski JQ. PMID: 27979356; PMCID: PMC5181646.
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Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis. 2017; 59(4):1307-1315. Bettcher BM, Ard MC, Reed BR, Benitez A, Simmons A, Larson EB, Sonnen JA, Montine TJ, Li G, Keene CD, Crane PK, Mungas D. PMID: 28731431; PMCID: PMC5604311.
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Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son. J Huntingtons Dis. 2017; 6(4):337-348. Latimer CS, Flanagan ME, Cimino PJ, Jayadev S, Davis M, Hoffer ZS, Montine TJ, Gonzalez-Cuyar LF, Bird TD, Keene CD. PMID: 29036832; PMCID: PMC5832043.
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Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease. J Neuropathol Exp Neurol. 2017 01 01; 76(1):39-43. Flanagan ME, Marshall DA, Shofer JB, Montine KS, Nelson PT, Montine TJ, Keene CD. PMID: 28062571; PMCID: PMC6251587.
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Mixed neuropathologies and estimated rates of clinical progression in a large autopsy sample. Alzheimers Dement. 2017 Jun; 13(6):654-662. Brenowitz WD, Hubbard RA, Keene CD, Hawes SE, Longstreth WT, Woltjer RL, Kukull WA. PMID: 27870939; PMCID: PMC5438283.
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Genome sequencing in a case of Niemann-Pick type C. Cold Spring Harb Mol Case Stud. 2016 11; 2(6):a001222. Dougherty M, Lazar J, Klein JC, Diaz K, Gobillot T, Grunblatt E, Hasle N, Lawrence D, Maurano M, Nelson M, Olson G, Srivatsan S, Shendure J, Keene CD, Bird T, Horwitz MS, Marshall DA. PMID: 27900365; PMCID: PMC5111003.
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Dysregulation of Elongation Factor 1A Expression is Correlated with Synaptic Plasticity Impairments in Alzheimer's Disease. J Alzheimers Dis. 2016 09 06; 54(2):669-78. Beckelman BC, Day S, Zhou X, Donohue M, Gouras GK, Klann E, Keene CD, Ma T. PMID: 27567813; PMCID: PMC5439429.
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Association of Traumatic Brain Injury With Late-Life Neurodegenerative Conditions and Neuropathologic Findings. JAMA Neurol. 2016 09 01; 73(9):1062-9. Crane PK, Gibbons LE, Dams-O'Connor K, Trittschuh E, Leverenz JB, Keene CD, Sonnen J, Montine TJ, Bennett DA, Leurgans S, Schneider JA, Larson EB. PMID: 27400367; PMCID: PMC5319642.
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Glucose levels during life and neuropathologic findings at autopsy among people never treated for diabetes. Neurobiol Aging. 2016 12; 48:72-82. Crane PK, Walker RL, Sonnen J, Gibbons LE, Melrose R, Hassenstab J, Keene CD, Postupna N, Montine TJ, Larson EB. PMID: 27644076; PMCID: PMC5441884.
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The phosphatase calcineurin regulates pathological TDP-43 phosphorylation. Acta Neuropathol. 2016 10; 132(4):545-61. Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Currey HN, Taylor LM, Wheeler JM, Oblak AL, Ghetti B, Montine TJ, Keene CD, Raskind MA, Bird TD, Kraemer BC. PMID: 27473149; PMCID: PMC5026939.
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Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines. Pathobiol Aging Age Relat Dis. 2016; 6:32397. Keene CD, Darvas M, Kraemer B, Liggitt D, Sigurdson C, Ladiges W. PMID: 27317189; PMCID: PMC4912600.
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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 2016 05 18; 90(4):724-39. Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. PMID: 27196974; PMCID: PMC4898967.
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Mutational status of IDH1 in uveal melanoma. Exp Mol Pathol. 2016 06; 100(3):476-81. Cimino PJ, Kung Y, Warrick JI, Chang SH, Keene CD. PMID: 27155448.
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Unbiased Stereological Analysis of Reactive Astrogliosis to Estimate Age-Associated Cerebral White Matter Injury. J Neuropathol Exp Neurol. 2016 06; 75(6):539-54. McNeal DW, Brandner DD, Gong X, Postupna NO, Montine TJ, Keene CD, Back SA. PMID: 27142644; PMCID: PMC6250206.
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Unusually long duration and delayed penetrance in a family with FTD and mutation in MAPT (V337M). Am J Med Genet B Neuropsychiatr Genet. 2017 01; 174(1):70-74. Domoto-Reilly K, Davis MY, Keene CD, Bird TD. PMID: 26990251; PMCID: PMC5297469.
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Precision Medicine: Clarity for the Complexity of Dementia. Am J Pathol. 2016 Mar; 186(3):500-6. Cholerton B, Larson EB, Quinn JF, Zabetian CP, Mata IF, Keene CD, Flanagan M, Crane PK, Grabowski TJ, Montine KS, Montine TJ. PMID: 26724389; PMCID: PMC4816691.
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Importance of home study visit capacity in dementia studies. Alzheimers Dement. 2016 Apr; 12(4):419-26. Crane PK, Gibbons LE, McCurry SM, McCormick W, Bowen JD, Sonnen J, Keene CD, Grabowski T, Montine TJ, Larson EB. PMID: 26602628; PMCID: PMC4841701.
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Multiplexed In-cell Immunoassay for Same-sample Protein Expression Profiling. Sci Rep. 2015 Sep 02; 5:13651. Shang J, Zrazhevskiy P, Postupna N, Keene CD, Montine TJ, Gao X. PMID: 26328896; PMCID: PMC4556981.
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Clinical-pathologic correlations in vascular cognitive impairment and dementia. Biochim Biophys Acta. 2016 05; 1862(5):945-51. Flanagan M, Larson EB, Latimer CS, Cholerton B, Crane PK, Montine KS, White LR, Keene CD, Montine TJ. PMID: 26319420; PMCID: PMC4769968.
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Corrigendum: Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 Sep 24; 525(7570):552. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA. PMID: 26176914; PMCID: PMC6451649.
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Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. J Neuropathol Exp Neurol. 2015 Jul; 74(7):672-87. Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. PMID: 26083568; PMCID: PMC4471879.
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Relative contributions of severe dopaminergic neuron ablation and dopamine depletion to cognitive impairment. Exp Neurol. 2015 Sep; 271:205-14. Morgan RG, Gibbs JT, Melief EJ, Postupna NO, Sherfield EE, Wilson A, Keene CD, Montine TJ, Palmiter RD, Darvas M. PMID: 26079646; PMCID: PMC4586402.
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Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature. 2015 May 21; 521(7552):E1-4. Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, Xu P, Tran S, Knobbe W, Leko V, Britt J, Starwalt R, McDaniel L, Ward CS, Parra D, Newcomb B, Lao U, Nourigat C, Flowers DA, Cullen S, Jorstad NL, Yang Y, Glaskova L, Vingeau S, Vigneau S, Kozlitina J, Yetman MJ, Jankowsky JL, Reichardt SD, Reichardt HM, Gärtner J, Bartolomei MS, Fang M, Loeb K, Keene CD, Bernstein I, Goodell M, Brat DJ, Huppke P, Neul JL, Bedalov A, Pieper AA. PMID: 25993969; PMCID: PMC4684952.
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Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 2015 Jul; 138(Pt 7):2005-19. Wang DB, Kinoshita Y, Kinoshita C, Uo T, Sopher BL, Cudaback E, Keene CD, Bilousova T, Gylys K, Case A, Jayadev S, Wang HG, Garden GA, Morrison RS. PMID: 25981964; PMCID: PMC4836404.
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Partial depletion of striatal dopamine enhances penetrance of cognitive deficits in a transgenic mouse model of Alzheimer's disease. J Neurosci Res. 2015 Sep; 93(9):1413-22. Melief EJ, Cudaback E, Jorstad NL, Sherfield E, Postupna N, Wilson A, Darvas M, Montine KS, Keene CD, Montine TJ. PMID: 25824456; PMCID: PMC4504797.
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Cerebral cortical Aβ42 and PHF-τ in 325 consecutive brain autopsies stratified by diagnosis, location, and APOE. J Neuropathol Exp Neurol. 2015 Feb; 74(2):100-9. Postupna N, Keene CD, Crane PK, Gonzalez-Cuyar LF, Sonnen JA, Hewitt J, Rice S, Howard K, Montine KS, Larson EB, Montine TJ. PMID: 25575135; PMCID: PMC4294957.
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Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB J. 2015 May; 29(5):1754-62. Li X, Montine KS, Keene CD, Montine TJ. PMID: 25593125; PMCID: PMC4415020.
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The APOE Gene is Differentially Methylated in Alzheimer's Disease. J Alzheimers Dis. 2015; 48(3):745-55. Foraker J, Millard SP, Leong L, Thomson Z, Chen S, Keene CD, Bekris LM, Yu CE. PMID: 26402071; PMCID: PMC6469491.
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Prostaglandin E2 receptor subtype 2 regulation of scavenger receptor CD36 modulates microglial Aβ42 phagocytosis. Am J Pathol. 2015 Jan; 185(1):230-9. Li X, Melief E, Postupna N, Montine KS, Keene CD, Montine TJ. PMID: 25452117; PMCID: PMC4278245.
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Wild-type bone marrow transplant partially reverses neuroinflammation in progranulin-deficient mice. Lab Invest. 2014 Nov; 94(11):1224-36. Yang Y, Aloi MS, Cudaback E, Josephsen SR, Rice SJ, Jorstad NL, Keene CD, Montine TJ. PMID: 25199051; PMCID: PMC4218738.
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APOE genotype-dependent modulation of astrocyte chemokine CCL3 production. Glia. 2015 Jan; 63(1):51-65. Cudaback E, Yang Y, Montine TJ, Keene CD. PMID: 25092803; PMCID: PMC4237722.
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Flow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease. Lab Invest. 2014 Oct; 94(10):1161-72. Postupna NO, Keene CD, Latimer C, Sherfield EE, Van Gelder RD, Ojemann JG, Montine TJ, Darvas M. PMID: 25068655; PMCID: PMC4184945.
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Therapeutic implications of the prostaglandin pathway in Alzheimer's disease. Biochem Pharmacol. 2014 Apr 15; 88(4):565-72. Cudaback E, Jorstad NL, Yang Y, Montine TJ, Keene CD. PMID: 24434190; PMCID: PMC3972296.
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The co-occurrence of Alzheimer's disease and Huntington's disease: a neuropathological study of 15 elderly Huntington's disease subjects. J Huntingtons Dis. 2014; 3(2):209-17. Davis MY, Keene CD, Jayadev S, Bird T. PMID: 25062863.
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Epigenetic signature and enhancer activity of the human APOE gene. Hum Mol Genet. 2013 Dec 15; 22(24):5036-47. Yu CE, Cudaback E, Foraker J, Thomson Z, Leong L, Lutz F, Gill JA, Saxton A, Kraemer B, Navas P, Keene CD, Montine T, Bekris LM. PMID: 23892237; PMCID: PMC3836480.
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APOE3, but not APOE4, bone marrow transplantation mitigates behavioral and pathological changes in a mouse model of Alzheimer disease. Am J Pathol. 2013 Sep; 183(3):905-17. Yang Y, Cudaback E, Jorstad NL, Hemingway JF, Hagan CE, Melief EJ, Li X, Yoo T, Khademi SB, Montine KS, Montine TJ, Keene CD. PMID: 23831297; PMCID: PMC3763765.
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Suppressed retinal degeneration in aged wild type and APPswe/PS1ΔE9 mice by bone marrow transplantation. PLoS One. 2013; 8(6):e64246. Yang Y, Shiao C, Hemingway JF, Jorstad NL, Shalloway BR, Chang R, Keene CD. PMID: 23750207; PMCID: PMC3672108.
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Perivascular, but not parenchymal, cerebral engraftment of donor cells after non-myeloablative bone marrow transplantation. Exp Mol Pathol. 2013 Aug; 95(1):7-17. Yang Y, Jorstad NL, Shiao C, Cherne MK, Khademi SB, Montine KS, Montine TJ, Keene CD. PMID: 23567123; PMCID: PMC3706527.
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A diagnostic dilemma: infectious versus noninfectious multifocal choroiditis with panuveitis. J Ophthalmic Inflamm Infect. 2013 Jan 28; 3(1):26. Ongchin S, Keene CD, Van Gelder R, Vemulakonda GA. PMID: 23514267; PMCID: PMC3605086.
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Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease. Exp Mol Pathol. 2013 Apr; 94(2):366-71. Cimino PJ, Yang Y, Li X, Hemingway JF, Cherne MK, Khademi SB, Fukui Y, Montine KS, Montine TJ, Keene CD. PMID: 23318649; PMCID: PMC3602334.
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Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models. Eur J Neurosci. 2013 Feb; 37(3):429-40. Horne EA, Coy J, Swinney K, Fung S, Cherry AE, Marrs WR, Naydenov AV, Lin YH, Sun X, Keene CD, Grouzmann E, Muchowski P, Bates GP, Mackie K, Stella N. PMID: 23167744; PMCID: PMC3699342.
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Gravin is a transitory effector of polo-like kinase 1 during cell division. Mol Cell. 2012 Nov 30; 48(4):547-59. Canton DA, Keene CD, Swinney K, Langeberg LK, Nguyen V, Pelletier L, Pawson T, Wordeman L, Stella N, Scott JD. PMID: 23063527; PMCID: PMC3513578.
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Apolipoprotein C-I is an APOE genotype-dependent suppressor of glial activation. J Neuroinflammation. 2012 Aug 10; 9:192. Cudaback E, Li X, Yang Y, Yoo T, Montine KS, Craft S, Montine TJ, Keene CD. PMID: 22883744; PMCID: PMC3490924.
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Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro. J Neuroimmune Pharmacol. 2013 Mar; 8(1):87-93. Li X, Rose SE, Montine KS, Keene CD, Montine TJ. PMID: 22718277; PMCID: PMC3700810.
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Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor. FASEB J. 2012 Jul; 26(7):3075-83. Li X, Cudaback E, Breyer RM, Montine KS, Keene CD, Montine TJ. PMID: 22499581; PMCID: PMC3382097.
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Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons. PLoS One. 2011; 6(11):e28168. Beutler LR, Eldred KC, Quintana A, Keene CD, Rose SE, Postupna N, Montine TJ, Palmiter RD. PMID: 22132236; PMCID: PMC3221701.
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Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults. Brain Pathol. 2012 Jul; 22(4):472-84. Postupna N, Rose SE, Bird TD, Gonzalez-Cuyar LF, Sonnen JA, Larson EB, Keene CD, Montine TJ. PMID: 21999410; PMCID: PMC3295908.
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Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment. Curr Neurol Neurosci Rep. 2011 Oct; 11(5):455-63. Gonzalez-Cuyar LF, Sonnen JA, Montine KS, Keene CD, Montine TJ. PMID: 21725901; PMCID: PMC3213691.
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Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease. Curr Opin Neurobiol. 2011 Dec; 21(6):920-8. Keene CD, Cudaback E, Li X, Montine KS, Montine TJ. PMID: 21907569; PMCID: PMC3237894.
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Apolipoprotein E isoform-dependent microglia migration. FASEB J. 2011 Jun; 25(6):2082-91. Cudaback E, Li X, Montine KS, Montine TJ, Keene CD. PMID: 21385991; PMCID: PMC3101033.
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Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation. Glia. 2011 Apr; 59(4):569-76. Li X, Cudaback E, Keene CD, Breyer RM, Montine TJ. PMID: 21319223; PMCID: PMC3082133.
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Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow. Am J Pathol. 2010 Jul; 177(1):346-54. Keene CD, Chang RC, Lopez-Yglesias AH, Shalloway BR, Sokal I, Li X, Reed PJ, Keene LM, Montine KS, Breyer RM, Rockhill JK, Montine TJ. PMID: 20522650; PMCID: PMC2893677.
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Protection of hippocampal neurogenesis from toll-like receptor 4-dependent innate immune activation by ablation of prostaglandin E2 receptor subtype EP1 or EP2. Am J Pathol. 2009 Jun; 174(6):2300-9. Keene CD, Chang R, Stephen C, Nivison M, Nutt SE, Look A, Breyer RM, Horner PJ, Hevner R, Montine TJ. PMID: 19389932; PMCID: PMC2684194.
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A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions. Acta Neuropathol. 2009 Mar; 117(3):329-38. Keene CD, Chang RC, Leverenz JB, Kopyov O, Perlman S, Hevner RF, Born DE, Bird TD, Montine TJ. PMID: 19057918; PMCID: PMC2676786.
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Proteomics of human neurodegenerative diseases. J Neuropathol Exp Neurol. 2008 Oct; 67(10):923-32. Zhang J, Keene CD, Pan C, Montine KS, Montine TJ. PMID: 18800015; PMCID: PMC2710115.
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Therapeutic targets in prostaglandin E2 signaling for neurologic disease. Curr Med Chem. 2008; 15(19):1863-9. Cimino PJ, Keene CD, Breyer RM, Montine KS, Montine TJ. PMID: 18691044; PMCID: PMC2693919.
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Biomarkers for Alzheimer's disease. Expert Rev Neurother. 2007 Aug; 7(8):1021-8. Sonnen JA, Keene CD, Montine KS, Li G, Peskind ER, Zhang J, Montine TJ. PMID: 17678497.
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