David Eisenberg | UCLA Profiles

In Vitro and In Vivo Evaluation of Small-Molecule Disassemblers of Pathological Tau Fibrils. ACS Chem Neurosci. 2026 Jan 21; 17(2):450-464. Pan H, Cheng X, Zhang J, Hou K, Murray KA, Manglani K, Zhu C, Hsu HK, Mekkittikul M, Halladay T, Mirbaha H, Elezi G, Abskharon R, Sawaya MR, Bombino A, Williams CK, DeTure M, Dickson DW, Vinters HV, Whitelegge JP, Harran PG, Cole GM, Frautschy SA, Eisenberg DS. PMID: 41486697.

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How Sup35 monomer conformation and amyloid fibril polymorphism determine yeast strain phenotypes. Res Sq. 2025 Nov 03. Tanaka M, Nomura T, Boyer D, Komi Y, Ge P, Maillard RA, Rodriguez P, Yamagata A, Shirouzu M, Legname G, Samori B, Eisenberg D. PMID: 41282265; PMCID: PMC12637829.

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Genetic and structural aspects of amyloid diseases. Sci Transl Med. 2025 Oct; 17(818):eadp3378. Rosenberg GM, Murray KA, Sawaya MR, Jiang YX, Geschwind DH, Eisenberg DS. PMID: 41032625.

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Leveraging structure-informed machine learning for fast steric zipper propensity prediction across whole proteomes. PLoS Comput Biol. 2025 Aug; 21(8):e1013395. Zink S, Qu S, Holton T, Shankar E, Stanley P, Eisenberg DS, Sawaya MR, Rodriguez JA. PMID: 40853992; PMCID: PMC12413084.

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A Biomimetic Twisting Strategy Enables Efficient Electrocatalytic Oxidation of Energy-Dense Hydrazine Hydrate on FeN2+2C4+4 Sites. J Am Chem Soc. 2025 Sep 03; 147(35):31731-31740. Offen-Polak I, Samala NR, Burshtein TY, Zahan SM, Xiang S, Shahaf Y, Studnik C, Ni L, Delgado-Jaime MU, Kramm U, Dekel DR, Vogt C, Frenkel AI, Grinberg I, Eisenberg D. PMID: 40839880; PMCID: PMC12412151.

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A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants. bioRxiv. 2025 Aug 07. Fernandez-Ramirez MDC, Afrin S, An Nguyen B, Singh V, Pekala M, Singh P, Ahmed Y, Pedretti R, Lemoff A, Kluve-Beckerman B, Chhapra F, Eisenberg D, Saelices L. PMID: 40799554; PMCID: PMC12340799.

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How short peptides disassemble tau fibrils in Alzheimer's disease. Nature. 2025 Aug; 644(8078):1020-1027. Hou K, Ge P, Sawaya MR, Lutter L, Dolinsky JL, Yang Y, Jiang YX, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Abskharon R, Yang S, Yu Z, Feigon J, Eisenberg DS. PMID: 40634605; PMCID: PMC12369647.

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A structure-guided antibody detects SOD1 oligomers in diverse ALS genotypes. bioRxiv. 2025 May 08. Sangwan S, Rieder HE, Moore D, Khanlou N, Novitch B, Geisberg M, Eisenberg DS. PMID: 40654973; PMCID: PMC12247632.

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Liganded magnetic nanoparticles for magnetic resonance imaging of α-synuclein. NPJ Parkinsons Dis. 2025 Apr 23; 11(1):88. Pan H, Balbirnie M, Hou K, Sta Maria NS, Sahay S, Denver P, Lepore S, Jones M, Zuo X, Zhu C, Mirbaha H, Shahpasand-Kroner H, Mekkittikul M, Lu J, Hu CJ, Cheng X, Abskharon R, Sawaya MR, Williams CK, Vinters HV, Jacobs RE, Harris NG, Cole GM, Frautschy SA, Eisenberg DS. PMID: 40268938; PMCID: PMC12019173.

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Formation of rippled β-sheets from mixed chirality linear and cyclic peptides-new structural motifs based on the pauling-corey rippled β-sheet. Chem Sci. 2025 Apr 02; 16(14):5907-5917. Hazari A, Sawaya MR, Lee H, Sajimon M, Kim H, Goddard Iii WA, Eisenberg D, Raskatov JA. PMID: 40060095; PMCID: PMC11884330.

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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. bioRxiv. 2024 Nov 04. Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Bravo CP, Bose R, Travaglini KJ, Lam VL, Goodness D, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan H, Carroll EC, Lawrence RE, Gestwicki JE, Eisenberg D, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. PMID: 37398204; PMCID: PMC10312804.

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How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. Res Sq. 2024 May 08. Eisenberg D, Hou K, Ge P, Sawaya M, Dolinsky J, Yang Y, Jiang YX, Lutter L, Boyer D, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J. PMID: 38766197; PMCID: PMC11100904.

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D-peptide-magnetic nanoparticles fragment tau fibrils and rescue behavioral deficits in a mouse model of Alzheimer's disease. Sci Adv. 2024 05 03; 10(18):eadl2991. Hou K, Pan H, Shahpasand-Kroner H, Hu C, Abskharon R, Seidler P, Mekkittikul M, Balbirnie M, Lantz C, Sawaya MR, Dolinsky JL, Jones M, Zuo X, Loo JA, Frautschy S, Cole G, Eisenberg DS. PMID: 38691615; PMCID: PMC11062580.

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How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. bioRxiv. 2024 Mar 29. Hou K, Ge P, Sawaya MR, Dolinsky JL, Yang Y, Jiang YX, Lutter L, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Yang S, Yu Z, Feigon J, Eisenberg DS. PMID: 38585812; PMCID: PMC10996594.

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DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity. bioRxiv. 2024 Jan 23. Ryder BD, Ustyantseva E, Boyer DR, Mendoza-Oliva A, Kuska M, Wydorski PM, Macierzynska P, Morgan N, Sawaya MR, Diamond MI, Kampinga HH, Joachimiak L. PMID: 36945632; PMCID: PMC10028812.

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Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy. Nat Commun. 2024 Jan 17; 15(1):581. Nguyen BA, Singh V, Afrin S, Yakubovska A, Wang L, Ahmed Y, Pedretti R, Fernandez-Ramirez MDC, Singh P, Pekala M, Cabrera Hernandez LO, Kumar S, Lemoff A, Gonzalez-Prieto R, Sawaya MR, Eisenberg DS, Benson MD, Saelices L. PMID: 38233397; PMCID: PMC10794703.

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Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J Biol Chem. 2024 02; 300(2):105531. Lu J, Ge P, Sawaya MR, Hughes MP, Boyer DR, Cao Q, Abskharon R, Cascio D, Tayeb-Fligelman E, Eisenberg DS. PMID: 38072051; PMCID: PMC10844680.

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Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. PNAS Nexus. 2023 Dec; 2(12):pgad402. Rosenberg GM, Abskharon R, Boyer DR, Ge P, Sawaya MR, Eisenberg DS. PMID: 38077690; PMCID: PMC10703350.

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Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 10 10; 120(41):e2300258120. Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 37801475; PMCID: PMC10576031.

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Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 2023 04 25; 14(1):2379. Tayeb-Fligelman E, Bowler JT, Tai CE, Sawaya MR, Jiang YX, Garcia G, Griner SL, Cheng X, Salwinski L, Lutter L, Seidler PM, Lu J, Rosenberg GM, Hou K, Abskharon R, Pan H, Zee CT, Boyer DR, Li Y, Anderson DH, Murray KA, Falcon G, Cascio D, Saelices L, Damoiseaux R, Arumugaswami V, Guo F, Eisenberg DS. PMID: 37185252; PMCID: PMC10127185.

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Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 02 14; 120(7):e2217835120. Murray KA, Hu CJ, Pan H, Lu J, Abskharon R, Bowler JT, Rosenberg GM, Williams CK, Elezi G, Balbirnie M, Faull KF, Vinters HV, Seidler PM, Eisenberg DS. PMID: 36757890; PMCID: PMC9963379.

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Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 09 16; 13(1):5451. Seidler PM, Murray KA, Boyer DR, Ge P, Sawaya MR, Hu CJ, Cheng X, Abskharon R, Pan H, DeTure MA, Williams CK, Dickson DW, Vinters HV, Eisenberg DS. PMID: 36114178; PMCID: PMC9481533.

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Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets. J Biol Chem. 2022 10; 298(10):102396. Bowler JT, Sawaya MR, Boyer DR, Cascio D, Bali M, Eisenberg DS. PMID: 35988647; PMCID: PMC9556795.

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De novo designed protein inhibitors of amyloid aggregation and seeding. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2206240119. Murray KA, Hu CJ, Griner SL, Pan H, Bowler JT, Abskharon R, Rosenberg GM, Cheng X, Seidler PM, Eisenberg DS. PMID: 35969734; PMCID: PMC9407671.

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The rippled β-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey. Chem Sci. 2022 Aug 10; 13(31):8947-8952. Hazari A, Sawaya MR, Vlahakis N, Johnstone TC, Boyer D, Rodriguez J, Eisenberg D, Raskatov JA. PMID: 36091211; PMCID: PMC9365095.

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Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies. Nat Struct Mol Biol. 2022 06; 29(6):529-536. Murray KA, Hughes MP, Hu CJ, Sawaya MR, Salwinski L, Pan H, French SW, Seidler PM, Eisenberg DS. PMID: 35637421; PMCID: PMC9205782.

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Bioinformatic identification of previously unrecognized amyloidogenic proteins. J Biol Chem. 2022 05; 298(5):101920. Rosenberg GM, Murray KA, Salwinski L, Hughes MP, Abskharon R, Eisenberg DS. PMID: 35405097; PMCID: PMC9108986.

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Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2119952119. Abskharon R, Sawaya MR, Boyer DR, Cao Q, Nguyen BA, Cascio D, Eisenberg DS. PMID: 35377792; PMCID: PMC9169762.

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Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature. 2022 05; 605(7909):304-309. Jiang YX, Cao Q, Sawaya MR, Abskharon R, Ge P, DeTure M, Dickson DW, Fu JY, Ogorzalek Loo RR, Loo JA, Eisenberg DS. PMID: 35344984; PMCID: PMC9844993.

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Atomic view of an amyloid dodecamer exhibiting selective cellular toxic vulnerability in acute brain slices. Protein Sci. 2022 03; 31(3):716-727. Gray ALH, Sawaya MR, Acharyya D, Lou J, Edington EM, Best MD, Prosser RA, Eisenberg DS, Do TD. PMID: 34954854; PMCID: PMC8862425.

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Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils. J Biol Chem. 2021 10; 297(4):101194. Hughes MP, Goldschmidt L, Eisenberg DS. PMID: 34537246; PMCID: PMC8551513.

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The expanding amyloid family: Structure, stability, function, and pathogenesis. Cell. 2021 09 16; 184(19):4857-4873. Sawaya MR, Hughes MP, Rodriguez JA, Riek R, Eisenberg DS. PMID: 34534463; PMCID: PMC8772536.

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Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores. Nat Struct Mol Biol. 2021 09; 28(9):724-730. Cao Q, Boyer DR, Sawaya MR, Abskharon R, Saelices L, Nguyen BA, Lu J, Murray KA, Kandeel F, Eisenberg DS. PMID: 34518699; PMCID: PMC10396428.

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Trichomonas vaginalis Detection in Urogenital Specimens from Symptomatic and Asymptomatic Men and Women by Use of the cobas TV/MG Test. J Clin Microbiol. 2021 09 20; 59(10):e0026421. Van Der Pol B, Rao A, Nye MB, Chavoustie S, Ermel A, Kaplan C, Eisenberg D, Chan PA, Mena L, Pacheco S, Waites KB, Xiao L, Krishnamurthy S, Mohan R, Bertuzis R, McGowin CL, Arcenas R, Marlowe EM, Taylor SN. PMID: 34319805; PMCID: PMC8451429.

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Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 2021 Mar 18. Tayeb-Fligelman E, Cheng X, Tai C, Bowler JT, Griner S, Sawaya MR, Seidler PM, Jiang YX, Lu J, Rosenberg GM, Salwinski L, Abskharon R, Zee CT, Hou K, Li Y, Boyer DR, Murray KA, Falcon G, Anderson DH, Cascio D, Saelices L, Damoiseaux R, Guo F, Eisenberg DS. PMID: 33688654; PMCID: PMC7941625.

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Intrinsic electronic conductivity of individual atomically resolved amyloid crystals reveals micrometer-long hole hopping via tyrosines. Proc Natl Acad Sci U S A. 2021 01 12; 118(2). Shipps C, Kelly HR, Dahl PJ, Yi SM, Vu D, Boyer D, Glynn C, Sawaya MR, Eisenberg D, Batista VS, Malvankar NS. PMID: 33372136; PMCID: PMC7812754.

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CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nat Commun. 2020 08 14; 11(1):4090. Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS. PMID: 32796831; PMCID: PMC7427792.

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Half a century of amyloids: past, present and future. Chem Soc Rev. 2020 Aug 07; 49(15):5473-5509. Ke PC, Zhou R, Serpell LC, Riek R, Knowles TPJ, Lashuel HA, Gazit E, Hamley IW, Davis TP, Fändrich M, Otzen DE, Chapman MR, Dobson CM, Eisenberg DS, Mezzenga R. PMID: 32632432; PMCID: PMC7445747.

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Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils. Nat Struct Mol Biol. 2020 07; 27(7):653-659. Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. PMID: 32541896; PMCID: PMC8579859.

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Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 2020 07 31; 295(31):10662-10676. Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. PMID: 32493775; PMCID: PMC7397112.

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Mycoplasma genitalium Detection in Urogenital Specimens from Symptomatic and Asymptomatic Men and Women by Use of the cobas TV/MG Test. J Clin Microbiol. 2020 05 26; 58(6). Van Der Pol B, Waites KB, Xiao L, Taylor SN, Rao A, Nye M, Chavoustie S, Ermel A, Kaplan C, Eisenberg D, Chan PA, Mena L, Pacheco S, Krishnamurthy S, Mohan R, Bertuzis R, McGowin CL, Arcenas R, Marlowe EM. PMID: 32213558; PMCID: PMC7269414.

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Cryo-EM structure of a human prion fibril with a hydrophobic, protease-resistant core. Nat Struct Mol Biol. 2020 05; 27(5):417-423. Glynn C, Sawaya MR, Ge P, Gallagher-Jones M, Short CW, Bowman R, Apostol M, Zhou ZH, Eisenberg DS, Rodriguez JA. PMID: 32284600; PMCID: PMC7338044.

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The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3592-3602. Boyer DR, Li B, Sun C, Fan W, Zhou K, Hughes MP, Sawaya MR, Jiang L, Eisenberg DS. PMID: 32015135; PMCID: PMC7035510.

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Inhibition of synucleinopathic seeding by rationally designed inhibitors. Elife. 2020 01 02; 9. Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. PMID: 31895037; PMCID: PMC6977966.

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Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid. Nat Commun. 2019 11 20; 10(1):5256. Basavalingappa V, Bera S, Xue B, Azuri I, Tang Y, Tao K, Shimon LJW, Sawaya MR, Kolusheva S, Eisenberg DS, Kronik L, Cao Y, Wei G, Gazit E. PMID: 31748568; PMCID: PMC6868146.

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Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat Struct Mol Biol. 2019 11; 26(11):1044-1052. Boyer DR, Li B, Sun C, Fan W, Sawaya MR, Jiang L, Eisenberg DS. PMID: 31695184; PMCID: PMC6907165.

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Structure-based inhibitors of amyloid beta core suggest a common interface with tau. Elife. 2019 10 15; 8. Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. PMID: 31612856; PMCID: PMC6850776.

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Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2019 Oct; 26(10):988. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 31530939; PMCID: PMC7103477.

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Non-proteinaceous hydrolase comprised of a phenylalanine metallo-supramolecular amyloid-like structure. Nat Catal. 2019 Nov; 2(11):977-985. Makam P, Yamijala SSRKC, Tao K, Shimon LJW, Eisenberg DS, Sawaya MR, Wong BM, Gazit E. PMID: 31742246; PMCID: PMC6861134.

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Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples. J Biol Chem. 2019 11 01; 294(44):16451-16464. Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. PMID: 31537646; PMCID: PMC6827308.

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Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nat Commun. 2019 07 26; 10(1):3357. Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. PMID: 31350392; PMCID: PMC6659688.

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Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nat Struct Mol Biol. 2019 07; 26(7):619-627. Cao Q, Boyer DR, Sawaya MR, Ge P, Eisenberg DS. PMID: 31235914; PMCID: PMC7047951.

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Structure-Based Peptide Inhibitor Design of Amyloid-β Aggregation. Front Mol Neurosci. 2019; 12:54. Lu J, Cao Q, Wang C, Zheng J, Luo F, Xie J, Li Y, Ma X, He L, Eisenberg D, Nowick J, Jiang L, Li D. PMID: 30886570; PMCID: PMC6409328.

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A pair of peptides inhibits seeding of the hormone transporter transthyretin into amyloid fibrils. J Biol Chem. 2019 04 12; 294(15):6130-6141. Saelices L, Nguyen BA, Chung K, Wang Y, Ortega A, Lee JH, Coelho T, Bijzet J, Benson MD, Eisenberg DS. PMID: 30733338; PMCID: PMC6463714.

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Humans

Author Correction: Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1267. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. PMID: 30420778; PMCID: PMC7124629.

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Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems. J Mol Biol. 2019 01 18; 431(2):289-307. Tuukkanen AT, Freire D, Chan S, Arbing MA, Reed RW, Evans TJ, Zenkeviciute G, Kim J, Kahng S, Sawaya MR, Chaton CT, Wilmanns M, Eisenberg D, Parret AHA, Korotkov KV. PMID: 30419243; PMCID: PMC6331215.

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PubMed

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8  

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Cells

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018 11; 563(7732):508-513. Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. PMID: 30464263; PMCID: PMC6324568.

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   Mentions:

125  

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Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis. J Biol Chem. 2018 12 21; 293(51):19659-19671. Brumshtein B, Esswein SR, Sawaya MR, Rosenberg G, Ly AT, Landau M, Eisenberg DS. PMID: 30355736; PMCID: PMC6314132.

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   Mentions:

18  

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Cells

Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design. Nat Chem. 2018 12; 10(12):1213-1221. Cao Q, Shin WS, Chan H, Vuong CK, Dubois B, Li B, Murray KA, Sawaya MR, Feigon J, Black DL, Eisenberg DS, Jiang L. PMID: 30297750; PMCID: PMC6250578.

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36  

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Assessment of the effects of transthyretin peptide inhibitors in Drosophila models of neuropathic ATTR. Neurobiol Dis. 2018 12; 120:118-125. Saelices L, Pokrzywa M, Pawelek K, Eisenberg DS. PMID: 30213731; PMCID: PMC6186191.

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8  

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HumansAnimals

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel. Nat Commun. 2018 09 06; 9(1):3609. Li B, Ge P, Murray KA, Sheth P, Zhang M, Nair G, Sawaya MR, Shin WS, Boyer DR, Ye S, Eisenberg DS, Zhou ZH, Jiang L. PMID: 30190461; PMCID: PMC6127345.

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   Mentions:

317  

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HumansAnimalsCells

Atomic insights into the genesis of cellular filaments by globular proteins. Nat Struct Mol Biol. 2018 08; 25(8):705-714. McPartland L, Heller DM, Eisenberg DS, Hochschild A, Sawaya MR. PMID: 30076408; PMCID: PMC6185745.

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Cells

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Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6741-E6750. Saelices L, Chung K, Lee JH, Cohn W, Whitelegge JP, Benson MD, Eisenberg DS. PMID: 29954863; PMCID: PMC6055172.

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   Mentions:

49  

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Humans

Crystal structures of amyloidogenic segments of human transthyretin. Protein Sci. 2018 07; 27(7):1295-1303. Saelices L, Sievers SA, Sawaya MR, Eisenberg DS. PMID: 29626847; PMCID: PMC6032358.

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   Mentions:

11  

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HumansCells

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nat Struct Mol Biol. 2018 06; 25(6):463-471. Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. PMID: 29786080; PMCID: PMC5990464.

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   Mentions:

131  

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Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nat Struct Mol Biol. 2018 04; 25(4):311-319. Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. PMID: 29531287; PMCID: PMC6056015.

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   Mentions:

55  

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HumansCells

Atomic structures of corkscrew-forming segments of SOD1 reveal varied oligomer conformations. Protein Sci. 2018 07; 27(7):1231-1242. Sangwan S, Sawaya MR, Murray KA, Hughes MP, Eisenberg DS. PMID: 29453800; PMCID: PMC6032342.

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HumansCells

Distal amyloid β-protein fragments template amyloid assembly. Protein Sci. 2018 07; 27(7):1181-1190. Do TD, Sangwan S, de Almeida NEC, Ilitchev AI, Giammona M, Sawaya MR, Buratto SK, Eisenberg DS, Bowers MT. PMID: 29349888; PMCID: PMC6032360.

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4  

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HumansCells

Cooperative Surface-Particle Catalysis: The Role of the "Active Doughnut" in Catalytic Oxidation. ChemCatChem. 2018 May 24; 10(10):2119-2124. Slot TK, Eisenberg D, Rothenberg G. PMID: 29937944; PMCID: PMC6001523.

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   Mentions:

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Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science. 2018 02 09; 359(6376):698-701. Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. PMID: 29439243; PMCID: PMC6192703.

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239  

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Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nat Struct Mol Biol. 2018 02; 25(2):131-134. Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, Gonen T, Rodriguez JA. PMID: 29335561; PMCID: PMC6170007.

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49  

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Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils. J Phys Chem B. 2018 01 11; 122(1):8-18. Hanczyc P, Mikhailovsky A, Boyer DR, Sawaya MR, Heeger A, Eisenberg D. PMID: 29237120; PMCID: PMC11721640.

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   Mentions:

3  

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Cells

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors. J Biol Chem. 2018 02 23; 293(8):2888-2902. Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. PMID: 29282295; PMCID: PMC5827424.

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36  

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Asparagine and glutamine ladders promote cross-species prion conversion. J Biol Chem. 2017 11 17; 292(46):19076-19086. Kurt TD, Aguilar-Calvo P, Jiang L, Rodriguez JA, Alderson N, Eisenberg DS, Sigurdson CJ. PMID: 28931606; PMCID: PMC5704488.

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   Mentions:

14  

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Toward the Atomic Structure of PrPSc. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). Rodriguez JA, Jiang L, Eisenberg DS. PMID: 28096267; PMCID: PMC5585850.

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Boosting the Supercapacitance of Nitrogen-Doped Carbon by Tuning Surface Functionalities. ChemSusChem. 2017 10 23; 10(20):4018-4024. Biemolt J, Denekamp IM, Slot TK, Rothenberg G, Eisenberg D. PMID: 28586123; PMCID: PMC5724695.

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   Mentions:

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Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8770-8775. Sangwan S, Zhao A, Adams KL, Jayson CK, Sawaya MR, Guenther EL, Pan AC, Ngo J, Moore DM, Soriaga AB, Do TD, Goldschmidt L, Nelson R, Bowers MT, Koehler CM, Shaw DE, Novitch BG, Eisenberg DS. PMID: 28760994; PMCID: PMC5565441.

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47  

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AnimalsCells

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327  

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HumansAnimalsCells

Neurodegeneration: Taming tangled tau. Nature. 2017 07 13; 547(7662):170-171. Eisenberg DS, Sawaya MR. PMID: 28678777; PMCID: PMC6400062.

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Humans

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18  

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HumansCells

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Cells

Atomic-resolution structures from fragmented protein crystals with the cryoEM method MicroED. Nat Methods. 2017 Feb 13; 14(4):399-402. de la Cruz MJ, Hattne J, Shi D, Seidler P, Rodriguez J, Reyes FE, Sawaya MR, Cascio D, Weiss SC, Kim SK, Hinck CS, Hinck AP, Calero G, Eisenberg D, Gonen T. PMID: 28192420; PMCID: PMC5376236.

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In memoriam-Rainer Jaenicke. Protein Sci. 2017 03; 26(3):394-395. Buchner J, Eisenberg D, Schmid F. PMID: 27977893; PMCID: PMC5326554.

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   Mentions:

241  

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Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 2017 01 03; 6. Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, Eisenberg DS. PMID: 28045370; PMCID: PMC5207774.

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61  

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201  

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De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure. Nature. 2016 11 03; 539(7627):43-47. Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, Koglin JE, Hunter MS, Park HW, Uervirojnangkoorn M, Bideshi DK, Brunger AT, Federici BA, Sauter NK, Eisenberg DS. PMID: 27680699; PMCID: PMC5161637.

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   Mentions:

65  

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Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):11232-11236. Sawaya MR, Rodriguez J, Cascio D, Collazo MJ, Shi D, Reyes FE, Hattne J, Gonen T, Eisenberg DS. PMID: 27647903; PMCID: PMC5056061.

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63  

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Cells

Implications for Alzheimer's disease of an atomic resolution structure of amyloid-β(1-42) fibrils. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9398-400. Eisenberg DS, Sawaya MR. PMID: 27506787; PMCID: PMC5003263.

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13  

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Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. BMC Struct Biol. 2016 Feb 27; 16:5. Wagner JM, Chan S, Evans TJ, Kahng S, Kim J, Arbing MA, Eisenberg D, Korotkov KV. PMID: 26922638; PMCID: PMC4769845.

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14  

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Cells

Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets. J Phys Chem B. 2016 07 07; 120(26):5810-6. Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D. PMID: 26629790; PMCID: PMC4936935.

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32  

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Amyloid β-Protein C-Terminal Fragments: Formation of Cylindrins and β-Barrels. J Am Chem Soc. 2016 Jan 20; 138(2):549-57. Do TD, LaPointe NE, Nelson R, Krotee P, Hayden EY, Ulrich B, Quan S, Feinstein SC, Teplow DB, Eisenberg D, Shea JE, Bowers MT. PMID: 26700445; PMCID: PMC4741107.

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51  

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Cells

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17  

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Health-related Culinary Education: A Summary of Representative Emerging Programs for Health Professionals and Patients. Glob Adv Health Med. 2016 Jan; 5(1):61-8. Polak R, Phillips EM, Nordgren J, La Puma J, La Barba J, Cucuzzella M, Graham R, Harlan TS, Burg T, Eisenberg D. PMID: 26937315; PMCID: PMC4756781.

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   Mentions:

55  

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Cells

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11; 29(1):90-103. Soragni A, Janzen DM, Johnson LM, Lindgren AG, Thai-Quynh Nguyen A, Tiourin E, Soriaga AB, Lu J, Jiang L, Faull KF, Pellegrini M, Memarzadeh S, Eisenberg DS. PMID: 26748848; PMCID: PMC4733364.

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   Mentions:

178  

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Ketones block amyloid entry and improve cognition in an Alzheimer's model. Neurobiol Aging. 2016 Mar; 39:25-37. Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J. PMID: 26923399.

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   Mentions:

74  

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Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife. 2015 Nov 18; 4:e10935. Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS. PMID: 26576950; PMCID: PMC4758944.

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Uncovering the Mechanism of Aggregation of Human Transthyretin. J Biol Chem. 2015 Nov 27; 290(48):28932-43. Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS. PMID: 26459562; PMCID: PMC4661406.

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81  

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Structure of the toxic core of α-synuclein from invisible crystals. Nature. 2015 Sep 24; 525(7570):486-90. Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, Brewster AS, Messerschmidt M, Boutet S, Sauter NK, Gonen T, Eisenberg DS. PMID: 26352473; PMCID: PMC4791177.

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319  

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Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Jun; 125(6):2548. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25961458; PMCID: PMC4497774.

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Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Mol Cell. 2015 Mar 19; 57(6):1011-1021. Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, Riekel C, Colletier JP, Riek R, Eisenberg DS, Simon HU. PMID: 25728769; PMCID: PMC4904734.

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55  

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Human prion protein sequence elements impede cross-species chronic wasting disease transmission. J Clin Invest. 2015 Apr; 125(4):1485-96. Kurt TD, Jiang L, Fernández-Borges N, Bett C, Liu J, Yang T, Spraker TR, Castilla J, Eisenberg D, Kong Q, Sigurdson CJ. PMID: 25705888; PMCID: PMC4396485.

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43  

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Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns. Acta Crystallogr D Biol Crystallogr. 2015 Feb; 71(Pt 2):357-66. Brewster AS, Sawaya MR, Rodriguez J, Hattne J, Echols N, McFarlane HT, Cascio D, Adams PD, Eisenberg DS, Sauter NK. PMID: 25664747; PMCID: PMC4321489.

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Cells

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31  

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Formation of amyloid fibers by monomeric light chain variable domains. J Biol Chem. 2014 Oct 03; 289(40):27513-25. Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS. PMID: 25138218; PMCID: PMC4183792.

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24  

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Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12769-74. Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, Shoeman RL, DePonte DP, Park HW, Federici BA, Sauter NK, Schlichting I, Eisenberg DS. PMID: 25136092; PMCID: PMC4156696.

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50  

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Factors that drive peptide assembly from native to amyloid structures: experimental and theoretical analysis of [leu-5]-enkephalin mutants. J Phys Chem B. 2014 Jul 03; 118(26):7247-56. Do TD, LaPointe NE, Sangwan S, Teplow DB, Feinstein SC, Sawaya MR, Eisenberg DS, Bowers MT. PMID: 24915112; PMCID: PMC4084844.

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The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1562-70. Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. PMID: 24711386; PMCID: PMC4000792.

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113  

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A synthetic biochemistry system for the in vitro production of isoprene from glycolysis intermediates. Protein Sci. 2014 May; 23(5):576-85. Korman TP, Sahachartsiri B, Li D, Vinokur JM, Eisenberg D, Bowie JU. PMID: 24623472; PMCID: PMC4005709.

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19  

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A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC. J Biol Chem. 2014 Apr 11; 289(15):10660-10667. Kurt TD, Jiang L, Bett C, Eisenberg D, Sigurdson CJ. PMID: 24596090; PMCID: PMC4036184.

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Cells

Designed amyloid fibers as materials for selective carbon dioxide capture. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):191-6. Li D, Furukawa H, Deng H, Liu C, Yaghi OM, Eisenberg DS. PMID: 24367077; PMCID: PMC3890842.

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   Mentions:

21  

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CellsPHPublic Health

Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):197-201. Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS. PMID: 24344300; PMCID: PMC3890817.

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77  

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Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. PLoS One. 2013; 8(11):e81753. Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D. PMID: 24312350; PMCID: PMC3843698.

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Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta. Elife. 2013 Jul 16; 2:e00857. Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS. PMID: 23878726; PMCID: PMC3713518.

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62  

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Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure. 2013 Apr 02; 21(4):627-37. Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. PMID: 23523424; PMCID: PMC3791866.

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21  

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Cells

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20913-8. Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. PMID: 23213214; PMCID: PMC3529048.

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HumansCells

The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Sci. 2012 Nov; 21(11):1754-67. Min AB, Miallau L, Sawaya MR, Habel J, Cascio D, Eisenberg D. PMID: 23011806; PMCID: PMC3527712.

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PubMed

   Mentions:

38  

   Fields: 

   Translation:

Cells

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. Nat Chem. 2012 Nov; 4(11):927-33. Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS. PMID: 23089868; PMCID: PMC3481199.

View in:

PubMed

   Mentions:

96  

   Fields: 

   Translation:

HumansAnimalsCells

Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell. 2012 May 11; 149(4):753-67. Kato M, Han TW, Xie S, Shi K, Du X, Wu LC, Mirzaei H, Goldsmith EJ, Longgood J, Pei J, Grishin NV, Frantz DE, Schneider JW, Chen S, Li L, Sawaya MR, Eisenberg D, Tycko R, McKnight SL. PMID: 22579281; PMCID: PMC6347373.

View in:

PubMed

   Mentions:

1141  

   Fields: 

   Translation:

AnimalsCells

Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7717-22. Stroud JC, Liu C, Teng PK, Eisenberg D. PMID: 22547798; PMCID: PMC3356606.

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PubMed

   Mentions:

131  

   Fields: 

   Translation:

Cells

The amyloid state of proteins in human diseases. Cell. 2012 Mar 16; 148(6):1188-203. Eisenberg D, Jucker M. PMID: 22424229; PMCID: PMC3353745.

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PubMed

   Mentions:

733  

   Fields: 

   Translation:

HumansAnimalsCells

Atomic view of a toxic amyloid small oligomer. Science. 2012 Mar 09; 335(6073):1228-31. Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. PMID: 22403391; PMCID: PMC3959867.

View in:

PubMed

   Mentions:

280  

   Fields: 

   Translation:

Cells

Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation. Protein Sci. 2012 Jan; 21(1):26-37. Teng PK, Anderson NJ, Goldschmidt L, Sawaya MR, Sambashivan S, Eisenberg D. PMID: 22095666; PMCID: PMC3323778.

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PubMed

   Mentions:

12  

   Fields: 

   Translation:

AnimalsCells

Molecular basis for amyloid-beta polymorphism. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):16938-43. Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. PMID: 21949245; PMCID: PMC3193189.

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PubMed

   Mentions:

154  

   Fields: 

   Translation:

HumansCells

PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods. 2011 Jun 29; 8(7):528-9. Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las Rivas J, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H. PMID: 21716279; PMCID: PMC3246345.

View in:

PubMed

   Mentions:

155  

   Fields: 

   Translation:

HumansAnimalsCells

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature. 2011 Jun 15; 475(7354):96-100. Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D. PMID: 21677644; PMCID: PMC4073670.

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PubMed

   Mentions:

201  

   Fields: 

   Translation:

Cells

Towards a pharmacophore for amyloid. PLoS Biol. 2011 Jun; 9(6):e1001080. Landau M, Sawaya MR, Faull KF, Laganowsky A, Jiang L, Sievers SA, Liu J, Barrio JR, Eisenberg D. PMID: 21695112; PMCID: PMC3114762.

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PubMed

   Mentions:

84  

   Fields: 

   Translation:

Cells

Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation. Protein Sci. 2011 Jun; 20(6):996-1004. Zhao M, Cascio D, Sawaya MR, Eisenberg D. PMID: 21462277; PMCID: PMC3104229.

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PubMed

   Mentions:

19  

   Fields: 

   Translation:

HumansCells

Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic β-sheet mimics. J Am Chem Soc. 2011 May 04; 133(17):6736-44. Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D. PMID: 21473620; PMCID: PMC3124511.

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PubMed

   Mentions:

39  

   Fields: 

   Translation:

HumansCells

Atomic structures suggest determinants of transmission barriers in mammalian prion disease. Biochemistry. 2011 Apr 05; 50(13):2456-63. Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D. PMID: 21323366; PMCID: PMC3068218.

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PubMed

   Mentions:

25  

   Fields: 

   Translation:

HumansAnimalsCells

Macrocyclic β-sheet peptides that inhibit the aggregation of a tau-protein-derived hexapeptide. J Am Chem Soc. 2011 Mar 09; 133(9):3144-57. Zheng J, Liu C, Sawaya MR, Vadla B, Khan S, Woods RJ, Eisenberg D, Goux WJ, Nowick JS. PMID: 21319744; PMCID: PMC3048834.

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PubMed

   Mentions:

50  

   Fields: 

   Translation:

HumansCells

The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb). 2011 Mar; 91(2):155-72. Chim N, Habel JE, Johnston JM, Krieger I, Miallau L, Sankaranarayanan R, Morse RP, Bruning J, Swanson S, Kim H, Kim CY, Li H, Bulloch EM, Payne RJ, Manos-Turvey A, Hung LW, Baker EN, Lott JS, James MN, Terwilliger TC, Eisenberg DS, Sacchettini JC, Goulding CW. PMID: 21247804; PMCID: PMC3310434.

View in:

PubMed

   Mentions:

21  

   Fields: 

   Translation:

HumansCells

β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol. 2011 Jan; 18(1):49-55. Liu C, Sawaya MR, Eisenberg D. PMID: 21131979; PMCID: PMC3058263.

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PubMed

   Mentions:

56  

   Fields: 

   Translation:

HumansCells

The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. Protein Sci. 2010 Sep; 19(9):1692-703. Arbing MA, Kaufmann M, Phan T, Chan S, Cascio D, Eisenberg D. PMID: 20629176; PMCID: PMC2975133.

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PubMed

   Mentions:

19  

   Fields: 

   Translation:

Cells

X-ray crystallographic structure of an artificial beta-sheet dimer. J Am Chem Soc. 2010 Aug 25; 132(33):11622-8. Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. PMID: 20669960; PMCID: PMC2929266.

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PubMed

   Mentions:

11  

   Fields: 

   Translation:

Cells

Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease. J Biol Chem. 2010 Sep 24; 285(39):29671-5. Apostol MI, Sawaya MR, Cascio D, Eisenberg D. PMID: 20685658; PMCID: PMC2943325.

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PubMed

   Mentions:

30  

   Fields: 

   Translation:

HumansCells

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PubMed

   Mentions:

16  

   Fields: 

   

Two amyloid States of the prion protein display significantly different folding patterns. J Mol Biol. 2010 Jul 23; 400(4):908-21. Ostapchenko VG, Sawaya MR, Makarava N, Savtchenko R, Nilsson KP, Eisenberg D, Baskakov IV. PMID: 20553730; PMCID: PMC2908243.

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PubMed

   Mentions:

49  

   Fields: 

   Translation:

AnimalsCells

Multidimensional structure-activity relationship of a protein in its aggregated states. Angew Chem Int Ed Engl. 2010 May 25; 49(23):3904-8. Wang L, Schubert D, Sawaya MR, Eisenberg D, Riek R. PMID: 20397175; PMCID: PMC3004770.

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PubMed

   Mentions:

25  

   Fields: 

   Translation:

Cells

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Sci. 2010 May; 19(5):1031-43. Laganowsky A, Benesch JL, Landau M, Ding L, Sawaya MR, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. PMID: 20440841; PMCID: PMC2868245.

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PubMed

   Mentions:

141  

   Fields: 

   Translation:

HumansAnimalsCells

Identifying the amylome, proteins capable of forming amyloid-like fibrils. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3487-92. Goldschmidt L, Teng PK, Riek R, Eisenberg D. PMID: 20133726; PMCID: PMC2840437.

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PubMed

   Mentions:

382  

   Fields: 

   Translation:

Cells

Detecting coordinated regulation of multi-protein complexes using logic analysis of gene expression. BMC Syst Biol. 2009 Dec 14; 3:115. Sprinzak E, Cokus SJ, Yeates TO, Eisenberg D, Pellegrini M. PMID: 20003439; PMCID: PMC2804736.

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PubMed

   Mentions:

9  

   Fields: 

   Translation:

AnimalsCells

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PubMed

   Mentions:

32  

   Fields: 

   

Molecular basis for insulin fibril assembly. Proc Natl Acad Sci U S A. 2009 Nov 10; 106(45):18990-5. Ivanova MI, Sievers SA, Sawaya MR, Wall JS, Eisenberg D. PMID: 19864624; PMCID: PMC2776439.

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PubMed

   Mentions:

115  

   Fields: 

   Translation:

Cells

Molecular mechanisms for protein-encoded inheritance. Nat Struct Mol Biol. 2009 Sep; 16(9):973-8. Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D. PMID: 19684598; PMCID: PMC3640378.

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PubMed

   Mentions:

127  

   Fields: 

   Translation:

HumansAnimalsCells

Short protein segments can drive a non-fibrillizing protein into the amyloid state. Protein Eng Des Sel. 2009 Aug; 22(8):531-6. Teng PK, Eisenberg D. PMID: 19602569; PMCID: PMC2719503.

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PubMed

   Mentions:

56  

   Fields: 

   Translation:

HumansAnimalsCells

Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process. Protein Sci. 2009 Jul; 18(7):1521-30. Wiltzius JJ, Sievers SA, Sawaya MR, Eisenberg D. PMID: 19475663; PMCID: PMC2775219.

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PubMed

   Mentions:

101  

   Fields: 

   Translation:

HumansCells

Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. PMID: 19541956; PMCID: PMC2865899.

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PubMed

   Mentions:

447  

   Fields: 

   Translation:

HumansAnimalsCells

Expanding metabolism for biosynthesis of nonnatural alcohols. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20653-8. Zhang K, Sawaya MR, Eisenberg DS, Liao JC. PMID: 19064911; PMCID: PMC2634914.

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PubMed

   Mentions:

98  

   Fields: 

   Translation:

Cells

Annotating proteins with generalized functional linkages. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17700-5. Llewellyn R, Eisenberg DS. PMID: 19004787; PMCID: PMC2584710.

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PubMed

   Mentions:

10  

   Fields: 

   

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PubMed

   Mentions:

2  

   Fields: 

   

Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J Biol Chem. 2009 Jan 02; 284(1):276-283. Miallau L, Faller M, Chiang J, Arbing M, Guo F, Cascio D, Eisenberg D. PMID: 18952600; PMCID: PMC2610494.

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PubMed

   Mentions:

70  

   Fields: 

   Translation:

Cells

A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell. 2008 Sep 19; 134(6):1007-18. Sawaya MR, Wojtowicz WM, Andre I, Qian B, Wu W, Baker D, Eisenberg D, Zipursky SL. PMID: 18805093; PMCID: PMC2701508.

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PubMed

   Mentions:

68  

   Fields: 

   Translation:

AnimalsCells

Identifying cognate binding pairs among a large set of paralogs: the case of PE/PPE proteins of Mycobacterium tuberculosis. PLoS Comput Biol. 2008 Sep 12; 4(9):e1000174. Riley R, Pellegrini M, Eisenberg D. PMID: 18787688; PMCID: PMC2519833.

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PubMed

   Mentions:

25  

   Fields: 

   Translation:

Cells

Bacterial inclusion bodies contain amyloid-like structure. PLoS Biol. 2008 Aug 05; 6(8):e195. Wang L, Maji SK, Sawaya MR, Eisenberg D, Riek R. PMID: 18684013; PMCID: PMC2494559.

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PubMed

   Mentions:

86  

   Fields: 

   Translation:

HumansAnimalsCells

Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J Clin Invest. 2008 Aug; 118(8):2917-28. Cruz D, Watson AD, Miller CS, Montoya D, Ochoa MT, Sieling PA, Gutierrez MA, Navab M, Reddy ST, Witztum JL, Fogelman AM, Rea TH, Eisenberg D, Berliner J, Modlin RL. PMID: 18636118; PMCID: PMC2467381.

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PubMed

   Mentions:

89  

   Fields: 

   

The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 2008 Sep; 17(9):1617-23. Guo Z, Eisenberg D. PMID: 18552127; PMCID: PMC2525518.

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PubMed

   Mentions:

7  

   Fields: 

   Translation:

Cells

Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin). Protein Sci. 2008 Sep; 17(9):1467-74. Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D. PMID: 18556473; PMCID: PMC2525530.

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PubMed

   Mentions:

147  

   Fields: 

   Translation:

HumansCells

Using inferred residue contacts to distinguish between correct and incorrect protein models. Bioinformatics. 2008 Jul 15; 24(14):1575-82. Miller CS, Eisenberg D. PMID: 18511466; PMCID: PMC2638260.

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PubMed

   Mentions:

22  

   Fields: 

   Translation:

Cells

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PubMed

   Mentions:

186  

   Fields: 

   Translation:

HumansCells

Draft crystal structure of the vault shell at 9-A resolution. PLoS Biol. 2007 Nov; 5(11):e318. Anderson DH, Kickhoefer VA, Sievers SA, Rome LH, Eisenberg D. PMID: 18044992; PMCID: PMC2229873.

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PubMed

   Mentions:

21  

   Fields: 

   Translation:

AnimalsCells

Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions. BMC Biol. 2007 Oct 09; 5:44. Kerrien S, Orchard S, Montecchi-Palazzi L, Aranda B, Quinn AF, Vinod N, Bader GD, Xenarios I, Wojcik J, Sherman D, Tyers M, Salama JJ, Moore S, Ceol A, Chatr-Aryamontri A, Oesterheld M, Stümpflen V, Salwinski L, Nerothin J, Cerami E, Cusick ME, Vidal M, Gilson M, Armstrong J, Woollard P, Hogue C, Eisenberg D, Cesareni G, Apweiler R, Hermjakob H. PMID: 17925023; PMCID: PMC2189715.

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PubMed

   Mentions:

142  

   Fields: 

   

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PubMed

   Mentions:

1  

   Fields: 

   Translation:

Cells

Toward rational protein crystallization: A Web server for the design of crystallizable protein variants. Protein Sci. 2007 Aug; 16(8):1569-76. Goldschmidt L, Cooper DR, Derewenda ZS, Eisenberg D. PMID: 17656576; PMCID: PMC2203352.

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PubMed

   Mentions:

164  

   Fields: 

   Translation:

HumansAnimalsCells

The minimum information required for reporting a molecular interaction experiment (MIMIx). Nat Biotechnol. 2007 Aug; 25(8):894-8. Orchard S, Salwinski L, Kerrien S, Montecchi-Palazzi L, Oesterheld M, Stümpflen V, Ceol A, Chatr-aryamontri A, Armstrong J, Woollard P, Salama JJ, Moore S, Wojcik J, Bader GD, Vidal M, Cusick ME, Gerstein M, Gavin AC, Superti-Furga G, Greenblatt J, Bader J, Uetz P, Tyers M, Legrain P, Fields S, Mulder N, Gilson M, Niepmann M, Burgoon L, De Las Rivas J, Prieto C, Perreau VM, Hogue C, Mewes HW, Apweiler R, Xenarios I, Eisenberg D, Cesareni G, Hermjakob H. PMID: 17687370.

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   Mentions:

113  

   Fields: 

   Translation:

Humans

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   Mentions:

10  

   Fields: 

   

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PubMed

   Mentions:

907  

   Fields: 

   Translation:

Cells

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PubMed

   Mentions:

2  

   Fields: 

   Translation:

HumansCells

The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol. 2007 Mar; 5(3):e16. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC. PMID: 17355171; PMCID: PMC1821046.

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PubMed

   Mentions:

339  

   Fields: 

   Translation:

PHPublic Health

Cooperative hydrogen bonding in amyloid formation. Protein Sci. 2007 Apr; 16(4):761-4. Tsemekhman K, Goldschmidt L, Eisenberg D, Baker D. PMID: 17327394; PMCID: PMC2203343.

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   Mentions:

52  

   Fields: 

   Translation:

Cells

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   Mentions:

4  

   Fields: 

   

A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen. 2007 Feb; 12(1):100-5. White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM. PMID: 17175524.

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   Mentions:

27  

   Fields: 

   Translation:

Cells

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   Mentions:

119  

   Fields: 

   Translation:

HumansAnimalsCells

The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function. J Mol Biol. 2007 Jan 12; 365(2):275-83. Goulding CW, Bowers PM, Segelke B, Lekin T, Kim CY, Terwilliger TC, Eisenberg D. PMID: 17064730.

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PubMed

   Mentions:

21  

   Fields: 

   Translation:

Cells

The structural biology of protein aggregation diseases: Fundamental questions and some answers. Acc Chem Res. 2006 Sep; 39(9):568-75. Eisenberg D, Nelson R, Sawaya MR, Balbirnie M, Sambashivan S, Ivanova MI, Madsen AØ, Riekel C. PMID: 16981672; PMCID: PMC3017558.

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PubMed

   Mentions:

55  

   Fields: 

   Translation:

Cells

Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8042-7. Guo Z, Eisenberg D. PMID: 16698921; PMCID: PMC1472426.

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PubMed

   Mentions:

38  

   Fields: 

   Translation:

Cells

Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8060-5. Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D. PMID: 16690741; PMCID: PMC1472429.

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   Mentions:

469  

   Fields: 

   Translation:

Cells

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   Mentions:

101  

   Fields: 

   Translation:

HumansCells

Bioinformatic challenges for the next decade(s). Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29; 361(1467):525-7. Eisenberg D, Marcotte E, McLachlan AD, Pellegrini M. PMID: 16524841; PMCID: PMC1609334.

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   Mentions:

4  

   Fields: 

   

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   Mentions:

127  

   Fields: 

   Translation:

Cells

A systematic screen of beta(2)-microglobulin and insulin for amyloid-like segments. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4079-82. Ivanova MI, Thompson MJ, Eisenberg D. PMID: 16537488; PMCID: PMC1449649.

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PubMed

   Mentions:

57  

   Fields: 

   Translation:

HumansCells

The 3D profile method for identifying fibril-forming segments of proteins. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4074-8. Thompson MJ, Sievers SA, Karanicolas J, Ivanova MI, Baker D, Eisenberg D. PMID: 16537487; PMCID: PMC1449648.

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   Mentions:

192  

   Fields: 

   Translation:

HumansAnimalsCells

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. PMID: 16497887.

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   Mentions:

1554  

   Fields: 

   Translation:

HumansCells

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   Mentions:

22  

   Fields: 

   Translation:

Cells

Unique transcriptome signature of Mycobacterium tuberculosis in pulmonary tuberculosis. Infect Immun. 2006 Feb; 74(2):1233-42. Rachman H, Strong M, Ulrichs T, Grode L, Schuchhardt J, Mollenkopf H, Kosmiadi GA, Eisenberg D, Kaufmann SH. PMID: 16428773; PMCID: PMC1360294.

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   Mentions:

119  

   Fields: 

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HumansCells

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   Mentions:

25  

   Fields: 

   Translation:

Cells

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   Mentions:

68  

   Fields: 

   Translation:

Cells

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   Mentions:

27  

   Fields: 

   Translation:

Humans

Utilizing logical relationships in genomic data to decipher cellular processes. FEBS J. 2005 Oct; 272(20):5110-8. Bowers PM, O'Connor BD, Cokus SJ, Sprinzak E, Yeates TO, Eisenberg D. PMID: 16218945.

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PubMed

   Mentions:

11  

   Fields: 

   Translation:

HumansAnimals

Inferring protein domain interactions from databases of interacting proteins. Genome Biol. 2005; 6(10):R89. Riley R, Lee C, Sabatti C, Eisenberg D. PMID: 16207360; PMCID: PMC1257472.

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   Mentions:

65  

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HumansAnimalsCells

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   Mentions:

100  

   Fields: 

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Cells

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   Mentions:

2  

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Structure of the cross-beta spine of amyloid-like fibrils. Nature. 2005 Jun 09; 435(7043):773-8. Nelson R, Sawaya MR, Balbirnie M, Madsen AØ, Riekel C, Grothe R, Eisenberg D. PMID: 15944695; PMCID: PMC1479801.

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863  

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17  

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Cells

Regulation by oligomerization in a mycobacterial folate biosynthetic enzyme. J Mol Biol. 2005 May 27; 349(1):61-72. Goulding CW, Apostol MI, Sawaya MR, Phillips M, Parseghian A, Eisenberg D. PMID: 15876368.

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21  

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7  

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Detection of parallel functional modules by comparative analysis of genome sequences. Nat Biotechnol. 2005 Feb; 23(2):253-60. Li H, Pellegrini M, Eisenberg D. PMID: 15696156.

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13  

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   Mentions:

87  

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Use of logic relationships to decipher protein network organization. Science. 2004 Dec 24; 306(5705):2246-9. Bowers PM, Cokus SJ, Eisenberg D, Yeates TO. PMID: 15618515.

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27  

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An amyloid-forming segment of beta2-microglobulin suggests a molecular model for the fibril. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10584-9. Ivanova MI, Sawaya MR, Gingery M, Attinger A, Eisenberg D. PMID: 15249659; PMCID: PMC489978.

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68  

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12  

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A web-based comparative genomics tutorial for investigating microbial genomes. Microbiol Educ. 2004 May; 5:30-5. Strong M, Cascio D, Eisenberg D. PMID: 23653555; PMCID: PMC3633132.

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2  

Prolinks: a database of protein functional linkages derived from coevolution. Genome Biol. 2004; 5(5):R35. Bowers PM, Pellegrini M, Thompson MJ, Fierro J, Yeates TO, Eisenberg D. PMID: 15128449; PMCID: PMC416471.

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126  

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236  

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PFIT and PFRIT: bioinformatic algorithms for detecting glycosidase function from structure and sequence. Protein Sci. 2004 Jan; 13(1):221-9. Kleiger G, Panina EM, Mallick P, Eisenberg D. PMID: 14691237; PMCID: PMC2286537.

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The Database of Interacting Proteins: 2004 update. Nucleic Acids Res. 2004 Jan 01; 32(Database issue):D449-51. Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D. PMID: 14681454; PMCID: PMC308820.

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   Mentions:

900  

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Visualization and interpretation of protein networks in Mycobacterium tuberculosis based on hierarchical clustering of genome-wide functional linkage maps. Nucleic Acids Res. 2003 Dec 15; 31(24):7099-109. Strong M, Graeber TG, Beeby M, Pellegrini M, Thompson MJ, Yeates TO, Eisenberg D. PMID: 14654685; PMCID: PMC291866.

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Cells

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11  

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Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30; 279(5):3516-24. Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. PMID: 14597624.

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33  

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The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12420-5. Hsu T, Hingley-Wilson SM, Chen B, Chen M, Dai AZ, Morin PM, Marks CB, Padiyar J, Goulding C, Gingery M, Eisenberg D, Russell RG, Derrick SC, Collins FM, Morris SL, King CH, Jacobs WR. PMID: 14557547; PMCID: PMC218773.

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   Mentions:

388  

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Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12; 301(5639):1527-30. Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M, Burdick A, Sarno EN, Wagner M, Röllinghoff M, Rea TH, Colonna M, Stenger S, Bloom BR, Eisenberg D, Modlin RL. PMID: 12970564.

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72  

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The discovery of the alpha-helix and beta-sheet, the principal structural features of proteins. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11207-10. Eisenberg D. PMID: 12966187; PMCID: PMC208735.

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62  

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Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophys Chem. 2003 Sep; 105(2-3):361-70. Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D. PMID: 14499904.

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12  

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Inference of protein function and protein linkages in Mycobacterium tuberculosis based on prokaryotic genome organization: a combined computational approach. Genome Biol. 2003; 4(9):R59. Strong M, Mallick P, Pellegrini M, Thompson MJ, Eisenberg D. PMID: 12952538; PMCID: PMC193659.

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40  

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42  

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AnimalsCells

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42  

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Heterogeneity of molecular targets on clonal cancer lines derived from a novel hormone-refractory prostate cancer tumor system. Prostate. 2003 Jun 01; 55(4):299-307. Freedland SJ, Pantuck AJ, Paik SH, Zisman A, Graeber TG, Eisenberg D, McBride WH, Nguyen D, Tso CL, Belldegrun AS. PMID: 12712409.

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6  

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33  

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Sharing publication-related data and materials: responsibilities of authorship in the life sciences. Plant Physiol. 2003 May; 132(1):19-24. Cech TR, Eddy SR, Eisenberg D, Hersey K, Holtzman SH, Poste GH, Raikhel NV, Scheller RH, Singer DB, Waltham MC, National Academics Committee on Responsibilities of Authorship in the Biological Sciences. PMID: 12746507; PMCID: PMC1540310.

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11  

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Crystal structures of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate. Protein Sci. 2003 May; 12(5):1097-108. Wang S, Eisenberg D. PMID: 12717031; PMCID: PMC2323879.

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26  

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The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs). Protein Sci. 2003 Apr; 12(4):832-47. Mura C, Kozhukhovsky A, Gingery M, Phillips M, Eisenberg D. PMID: 12649441; PMCID: PMC2323858.

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24  

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Structure and assembly of an augmented Sm-like archaeal protein 14-mer. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4539-44. Mura C, Phillips M, Kozhukhovsky A, Eisenberg D. PMID: 12668760; PMCID: PMC404694.

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21  

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Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity. J Mol Biol. 2003 Mar 07; 326(5):1559-75. Mura C, Katz JE, Clarke SG, Eisenberg D. PMID: 12595266.

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Selective dimerization of a C2H2 zinc finger subfamily. Mol Cell. 2003 Feb; 11(2):459-70. McCarty AS, Kleiger G, Eisenberg D, Smale ST. PMID: 12620233.

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51  

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Granulysin crystal structure and a structure-derived lytic mechanism. J Mol Biol. 2003 Jan 10; 325(2):355-65. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. PMID: 12488100.

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The directional atomic solvation energy: an atom-based potential for the assignment of protein sequences to known folds. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16041-6. Mallick P, Weiss R, Eisenberg D. PMID: 12461172; PMCID: PMC138561.

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8  

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Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution. Protein Sci. 2002 Dec; 11(12):2887-93. Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D. PMID: 12441386; PMCID: PMC2373750.

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Genomic evidence that the intracellular proteins of archaeal microbes contain disulfide bonds. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9679-84. Mallick P, Boutz DR, Eisenberg D, Yeates TO. PMID: 12107280; PMCID: PMC124975.

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72  

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Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Biochemistry. 2002 Jun 04; 41(22):6920-7. Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D. PMID: 12033924.

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24  

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The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord. 2002 Jun; 2(2):121-41. Goulding CW, Apostol M, Anderson DH, Gill HS, Smith CV, Kuo MR, Yang JK, Waldo GS, Suh SW, Chauhan R, Kale A, Bachhawat N, Mande SC, Johnston JM, Lott JS, Baker EN, Arcus VL, Leys D, McLean KJ, Munro AW, Berendzen J, Sharma V, Park MS, Eisenberg D, Sacchettini J, Alber T, Rupp B, Jacobs W, Terwilliger TC. PMID: 12462144.

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25  

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3D domain swapping: as domains continue to swap. Protein Sci. 2002 Jun; 11(6):1285-99. Liu Y, Eisenberg D. PMID: 12021428; PMCID: PMC2373619.

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   Mentions:

273  

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A hierarchic approach to the design of hexameric helical barrels. J Mol Biol. 2002 May 24; 319(1):243-53. Ghirlanda G, Lear JD, Ogihara NL, Eisenberg D, DeGrado WF. PMID: 12051949.

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89  

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220  

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Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets. Acta Crystallogr D Biol Crystallogr. 2002 Apr; 58(Pt 4):571-8. Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D. PMID: 11914479.

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11  

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Structures of the two 3D domain-swapped RNase A trimers. Protein Sci. 2002 Feb; 11(2):371-80. Liu Y, Gotte G, Libonati M, Eisenberg D. PMID: 11790847; PMCID: PMC2373430.

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43  

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AnimalsCells

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12  

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Cells

DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 2002 Jan 01; 30(1):303-5. Xenarios I, Salwínski L, Duan XJ, Higney P, Kim SM, Eisenberg D. PMID: 11752321; PMCID: PMC99070.

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   Mentions:

549  

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   Mentions:

219  

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Animals

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   Mentions:

139  

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2  

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