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Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening. Nat Commun. 2025 01 02; 16(1):152. Liu H, Zask A, Forouhar F, Iketani S, Williams A, Vaz DR, Habashi D, Choi K, Resnick SJ, Hong SJ, Lovett DH, Bai T, Chavez A, Ho DD, Stockwell BR. PMID: 39747827; PMCID: PMC11696555.
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Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility. J Biomed Mater Res A. 2020 08 01; 108(8):1736-1746. Spaulding KA, Zhu Y, Takaba K, Ramasubramanian A, Badathala A, Haraldsson H, Collins A, Aguayo E, Shah C, Wallace AW, Ziats NP, Lovett DH, Baker AJ, Healy KE, Ratcliffe MB. PMID: 32270584; PMCID: PMC8174154.
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Nonsurgical Periodontal Therapy in CKD: Findings of the Kidney and Periodontal Disease (KAPD) Pilot Randomized Controlled Trial. Kidney Med. 2020 Jan-Feb; 2(1):49-58. Grubbs V, Garcia F, Vittinghoff E, Jue BL, Ryder M, Lovett DH, Offenbacher S, Taylor G, Ganz P, Bibbins-Domingo K, Powe NR. PMID: 32734226; PMCID: PMC7380373.
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Enhanced cardiac expression of two isoforms of matrix metalloproteinase-2 in experimental diabetes mellitus. PLoS One. 2019; 14(8):e0221798. Lee HW, Lee SJ, Lee MY, Park MW, Kim SS, Shin N, Lovett DH, Bae SS, Ahn J, Park JS, Oh JH, Choi JH, Lee HC, Cha KS, Hong TJ, Song SH. PMID: 31461499; PMCID: PMC6713391.
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Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments and Tendons Journal. 2019 Jan 1; 03(01):35. Zhang ZQ, Joshi JS, Lovett LD, Manzano MG, Kim KH, Liu LX. .
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Reversal of right ventricular failure by chronic α1A-subtype adrenergic agonist therapy. Am J Physiol Heart Circ Physiol. 2019 01 01; 316(1):H224-H232. Cowley PM, Wang G, Swigart PM, Raghunathan A, Reddy N, Dulam P, Lovett DH, Simpson PC, Baker AJ. PMID: 30412439; PMCID: PMC6859419.
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The expression of two isoforms of matrix metalloproteinase-2 in aged mouse models of diabetes mellitus and chronic kidney disease. Kidney Res Clin Pract. 2018 Sep; 37(3):222-229. Rhee H, Han M, Kim SS, Kim IY, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. PMID: 30254846; PMCID: PMC6147188.
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The two isoforms of matrix metalloproteinase- 2 have distinct renal spatial and temporal distributions in murine models of types 1 and 2 diabetes mellitus. BMC Nephrol. 2018 09 25; 19(1):248. Kim IY, Kim SS, Lee HW, Bae SS, Ha HK, Jung ES, Lee MY, Han M, Rhee H, Seong EY, Lee DW, Lee SB, Lovett DH, Song SH. PMID: 30253743; PMCID: PMC6156952.
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Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility. PLoS One. 2018; 13(2):e0192720. Spaulding K, Takaba K, Collins A, Faraji F, Wang G, Aguayo E, Ge L, Saloner D, Wallace AW, Baker AJ, Lovett DH, Ratcliffe MB. PMID: 29432443; PMCID: PMC5809072.
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α1A-Subtype adrenergic agonist therapy for the failing right ventricle. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1109-H1118. Cowley PM, Wang G, Joshi S, Swigart PM, Lovett DH, Simpson PC, Baker AJ. PMID: 28822963; PMCID: PMC5814653.
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Hyperpolarized 13 C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017 Oct; 30(10). Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. PMID: 28708304; PMCID: PMC5618802.
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Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Physiol Rep. 2017 Jun; 5(11). Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP. PMID: 28596300; PMCID: PMC5471444.
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MP501A SPATIAL DISTRIBUTION OF TWO ISOFORMS OF MATRIX METALLOPROTEINASE-2 IN DIABETIC KIDNEY ACCORDING TO THE TIME OF DIABETIC MILIEU. Nephrology,Dialysis and Transplantation. 2017 May 1; 32(suppl_3):iii612-iii613. Song SS, Rhee RH, Kim KI, Seong SE, Lee LD, Lee LS, Kwak KI, Lee LM, Bang BS, Lovett LD. .
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a1A-Subtype Adrenergic Agonist Therapy for Failing Right Ventricle. The FASEB Journal. 2017 Apr 1; 31(S1). Cowley CP, Wang WG, Swigart SP, Lovett LD, Simpson SP, Baker BA. .
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An intracellular matrix metalloproteinase-2 isoform induces tubular regulated necrosis: implications for acute kidney injury. Am J Physiol Renal Physiol. 2017 06 01; 312(6):F1166-F1183. Ceron CS, Baligand C, Joshi S, Wanga S, Cowley PM, Walker JP, Song SH, Mahimkar R, Baker AJ, Raffai RL, Wang ZJ, Lovett DH. PMID: 28331061; PMCID: PMC5495883.
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Enhanced expression of two discrete isoforms of matrix metalloproteinase-2 in experimental and human diabetic nephropathy. PLoS One. 2017; 12(2):e0171625. Kim SS, Shin N, Bae SS, Lee MY, Rhee H, Kim IY, Seong EY, Lee DW, Lee SB, Kwak IS, Lovett DH, Song SH. PMID: 28178341; PMCID: PMC5298282.
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The Kidney and Periodontal Disease (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on chronic kidney disease. Contemp Clin Trials. 2017 02; 53:143-150. Grubbs V, Garcia F, Jue BL, Vittinghoff E, Ryder M, Lovett D, Carrillo J, Offenbacher S, Ganz P, Bibbins-Domingo K, Powe NR. PMID: 28011387; PMCID: PMC6237429.
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a1A-Subtype Adrenergic Therapy is Beneficial for Failing Right Ventricle (RV). The FASEB Journal. 2016 Apr 1; 30(S1). Cowley CP, Wang WG, Joshi JS, Lovett LD, Simpson SP, Baker BA. .
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Immunosuppression With FTY720 Reverses Cardiac Dysfunction in Hypomorphic ApoE Mice Deficient in SR-BI Expression That Survive Myocardial Infarction Caused by Coronary Atherosclerosis. J Cardiovasc Pharmacol. 2016 Jan; 67(1):47-56. Luk FS, Kim RY, Li K, Ching D, Wong DK, Joshi SK, Imhof I, Honbo N, Hoover H, Zhu BQ, Lovett DH, Karliner JS, Raffai RL. PMID: 26322923; PMCID: PMC4703534.
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Abstract 17311: Molecular Memory and the Epigenetic Regulation of Cardiac Intracellular Matrix Metalloproteinase-2. Circulation. 2015 Nov 10; 132(suppl_3). Lovett LD, Luk LS, Uttarwar UL, Joshi JS, RAffai RR. .
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Two Distinct Isoforms of Matrix Metalloproteinase-2 Are Associated with Human Delayed Kidney Graft Function. PLoS One. 2015; 10(9):e0136276. Wanga S, Ceron CS, Delgado C, Joshi SK, Spaulding K, Walker JP, Song S, Olson JL, Lovett DH. PMID: 26379248; PMCID: PMC4574928.
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The α1A-adrenergic receptor subtype mediates increased contraction of failing right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2015 Sep; 309(5):H888-96. Cowley PM, Wang G, Chang AN, Makwana O, Swigart PM, Lovett DH, Stull JT, Simpson PC, Baker AJ. PMID: 26116709; PMCID: PMC4591405.
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RR15. Renal Progression in the Advanced Chronic Kidney Disease Populations: Creation of the ESRD Prediction Scorecard. Journal of Vascular Surgery. 2015 Jun 1; 61(6):195s. Lau LM, Meier MJ, Gasper GW, Lovett LD, Velez VP, Owens OC. .
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FP458THE EXPRESSION OF FULL LENGTH MMP-2 AND INTRACELLULAR N-TERMINAL TRUNCATED MMP-2 ISOFORM IN DIABETIC KIDNEY DISEASE. Nephrology,Dialysis and Transplantation. 2015 May 1; 30(suppl_3):iii224-iii224. Song SS, Kwak KI, Lee LM, Seong SE, Rhee RH, Kim KI, Lee LD, Lee LS, Lovett LD. .
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Abstract 23: Immunosuppression with FTY720 Reverses Cardiac Dysfunction to Prevent Chronic Heart Failure in Mice that Survive Diet-induced Myocardial Infarction. Arteriosclerosis Thrombosis and Vascular Biology. 2015 May 1; 35(suppl_1). Luk LF, Kim KR, Li LK, Ching CD, Joshi JS, Honbo HN, Imhof II, Zhu ZB, Lovett LD, Karliner KJ, Raffai RR. .
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The nucleus is an intracellular propagator of tensile forces in NIH 3T3 fibroblasts. J Cell Sci. 2015 May 15; 128(10):1901-11. Alam SG, Lovett D, Kim DI, Roux KJ, Dickinson RB, Lele TP. PMID: 25908852; PMCID: PMC4457156.
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Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Oct-Dec; 4(4):446-54. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim HT, Liu X. PMID: 25767782; PMCID: PMC4327354.
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Upregulation of a1A-Subtype Adrenergic Signaling is Beneficial in Failing Right Ventricle (RV). Biophysical Journal. 2015 Jan 1; 108(2):293a-294a. Cowley CP, Wang WG, Chang CA, Lovett LD, Stull SJ, Simpson SP, Baker BA. .
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Navigating toward research success in times of uncertainty: funding opportunities for early career investigators in nephrology. Am J Kidney Dis. 2015 Mar; 65(3):381-3. Ikizler TA, Lovett DH, Chertow GM, Mitch WE, Schiller B. PMID: 25542413.
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Matrix metalloproteinase-2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscles Ligaments Tendons J. 2014 Jul; 4(3):362-70. Zhang Q, Joshi SK, Lovett DH, Zhang B, Bodine S, Kim H, Liu X. PMID: 25489556; PMCID: PMC4241429.
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A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium. Front Physiol. 2014; 5:363. Lovett DH, Chu C, Wang G, Ratcliffe MB, Baker AJ. PMID: 25309453; PMCID: PMC4174733.
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Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1150-8. Shimkunas R, Makwana O, Spaulding K, Bazargan M, Khazalpour M, Takaba K, Soleimani M, Myagmar BE, Lovett DH, Simpson PC, Ratcliffe MB, Baker AJ. PMID: 25128171; PMCID: PMC4200338.
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Abstract 363: Prolonged Upregulation of Proinflammatory and Profibrotic Genes is Characteristic of Successful Arteriovenous Fistula Maturation. Arteriosclerosis Thrombosis and Vascular Biology. 2014 May 1; 34(suppl_1). Walker WJ, Toy TR, Thomas TS, Conte CM, Eichler EC, Lovett LD, Gasper GW, Owens OC. .
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Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease. J Vasc Surg. 2014 Jul; 60(1):176-83. Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD. PMID: 24582700; PMCID: PMC4074433.
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N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic heart failure. PLoS One. 2013; 8(7):e68154. Lovett DH, Mahimkar R, Raffai RL, Cape L, Zhu BQ, Jin ZQ, Baker AJ, Karliner JS. PMID: 23874529; PMCID: PMC3712965.
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Original article Muscle extracellular matrix degradation and contractibility following tendon rupture and disuse. Muscles Ligaments Tendons J. 2013 Jan; 3(1):35-41. Zhang Q, Joshi SK, Manzano G, Lovett DH, Kim HT, Liu X. PMID: 23885343; PMCID: PMC3676162.
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Vitamin D Deficiency Is Associated With Mortality and Adverse Vascular Access Outcomes in the ESRD Population. Journal of Vascular Surgery. 2013 May 1; 57(5):101s. Walker WJ, Hiramoto HJ, Auyang AP, Alley AH, Conte CM, Lovett LD, Rapp RJ, Owens OC. .
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Intraventricular and interventricular cellular heterogeneity of inotropic responses to α(1)-adrenergic stimulation. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H946-53. Chu C, Thai K, Park KW, Wang P, Makwana O, Lovett DH, Simpson PC, Baker AJ. PMID: 23355341; PMCID: PMC3625891.
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mTOR regulates fatty infiltration through SREBP-1 and PPARγ after a combined massive rotator cuff tear and suprascapular nerve injury in rats. J Orthop Res. 2013 May; 31(5):724-30. Joshi SK, Liu X, Samagh SP, Lovett DH, Bodine SC, Kim HT, Feeley BT. PMID: 23239524; PMCID: PMC4393845.
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Connective tissue growth factor regulates retinal neovascularization through p53 protein-dependent transactivation of the matrix metalloproteinase (MMP)-2 gene. J Biol Chem. 2012 Nov 23; 287(48):40570-85. Chintala H, Liu H, Parmar R, Kamalska M, Kim YJ, Lovett D, Grant MB, Chaqour B. PMID: 23048035; PMCID: PMC3504771.
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A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS One. 2012; 7(4):e34177. Lovett DH, Mahimkar R, Raffai RL, Cape L, Maklashina E, Cecchini G, Karliner JS. PMID: 22509276; PMCID: PMC3317925.
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The safety of an adenosine A(1)-receptor antagonist, rolofylline, in patients with acute heart failure and renal impairment: findings from PROTECT. Drug Saf. 2012 Mar 01; 35(3):233-44. Teerlink JR, Iragui VJ, Mohr JP, Carson PE, Hauptman PJ, Lovett DH, Miller AB, Piña IL, Thomson S, Varosy PD, Zile MR, Cleland JG, Givertz MM, Metra M, Ponikowski P, Voors AA, Davison BA, Cotter G, Wolko D, Delucca P, Salerno CM, Mansoor GA, Dittrich H, O'Connor CM, Massie BM. PMID: 22339573.
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Abstract 18433: A Novel Intracellular Isoform of Matrix Metalloproteinase-2 Activates Innate Immunity and Leads to Cardiac Failure. Circulation. 2011 Nov 22; 124(suppl_21). Lovett LD, Mahimkar MR, Maklashina ME, Cecchini CG, Karliner KJ. .
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Graded activation of the MEK1/MT1-MMP axis determines renal epithelial cell tumor phenotype. Carcinogenesis. 2011 Dec; 32(12):1806-14. Mahimkar R, Alfonso-Jaume MA, Cape LM, Dahiya R, Lovett DH. PMID: 21965271; PMCID: PMC3220610.
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Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):253-60. Findeisen HM, Gizard F, Zhao Y, Cohn D, Heywood EB, Jones KL, Lovett DH, Howatt DA, Daugherty A, Bruemmer D. PMID: 21088250; PMCID: PMC3025410.
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Transgenic expression of matrix metalloproteinase-2 induces coronary artery ectasia. Int J Exp Pathol. 2011 Feb; 92(1):50-6. Dahi S, Karliner JS, Sarkar R, Lovett DH. PMID: 21039989; PMCID: PMC3052756.
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YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis. Biochem Biophys Res Commun. 2010 Jul 30; 398(3):482-8. Lovett DH, Cheng S, Cape L, Pollock AS, Mertens PR. PMID: 20599698; PMCID: PMC2925540.
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Mechanisms of matrix metalloproteinase-2 (mmp-2) transcriptional repression by progesterone in jar choriocarcinoma cells. Reprod Biol Endocrinol. 2009 May 09; 7:41. Goldman S, Lovett DH, Shalev E. PMID: 19426551; PMCID: PMC2687445.
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Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous valve degeneration: a potential model of mitral valve prolapse disease. Cardiovasc Pathol. 2009 Sep-Oct; 18(5):253-61. Mahimkar R, Nguyen A, Mann M, Yeh CC, Zhu BQ, Karliner JS, Lovett DH. PMID: 18835790; PMCID: PMC3367668.
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Associations of interleukin-6, C-reactive protein and serum amyloid A with mortality in haemodialysis patients. Nephrology (Carlton). 2008 Oct; 13(7):593-600. Wetmore JB, Lovett DH, Hung AM, Cook-Wiens G, Mahnken JD, Sen S, Johansen KL. PMID: 18826487; PMCID: PMC3375899.
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Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H205-12. McCloskey DT, Turcato S, Wang GY, Turnbull L, Zhu BQ, Bambino T, Nguyen AP, Lovett DH, Nissenson RA, Karliner JS, Baker AJ. PMID: 17965283; PMCID: PMC3372085.
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Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):189-95. Zhou HZ, Ma X, Gray MO, Zhu BQ, Nguyen AP, Baker AJ, Simonis U, Cecchini G, Lovett DH, Karliner JS. PMID: 17475219; PMCID: PMC3423089.
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Regulation of MMP-2 gene transcription in dermal wounds. J Invest Dermatol. 2007 Jul; 127(7):1762-7. Jansen PL, Rosch R, Jansen M, Binnebösel M, Junge K, Alfonso-Jaume A, Klinge U, Lovett DH, Mertens PR. PMID: 17344928.
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Polymeric meshes induce zonal regulation of matrix metalloproteinase-2 gene expression by macrophages and fibroblasts. FASEB J. 2007 Apr; 21(4):1047-57. Jansen PL, Kever M, Rosch R, Krott E, Jansen M, Alfonso-Jaume A, Dooley S, Klinge U, Lovett DH, Mertens PR. PMID: 17215487.
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Biomaterials: Disturbing Factors in Cell Cross-Talk and Gene Regulation. Recurrent Hernia. 2007 Jan 1; 63-67. Lynen-Jansen LP, Klinge KU, Lovett LD, Mertens MP. .
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Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction. Am J Physiol Heart Circ Physiol. 2007 Apr; 292(4):H1847-60. Bergman MR, Teerlink JR, Mahimkar R, Li L, Zhu BQ, Nguyen A, Dahi S, Karliner JS, Lovett DH. PMID: 17158653.
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Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J. 2006 Sep; 20(11):1898-900. Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH. PMID: 16891619.
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An angiotensin converting enzyme haplotype predicts survival in patients with end stage renal disease. Hum Genet. 2006 Sep; 120(2):201-10. Wetmore JB, Johansen KL, Sen S, Hung AM, Lovett DH. PMID: 16791616.
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Selective spatiotemporal induction of matrix metalloproteinase-2 and matrix metalloproteinase-9 transcription after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2216-28. Mukherjee R, Mingoia JT, Bruce JA, Austin JS, Stroud RE, Escobar GP, McClister DM, Allen CM, Alfonso-Jaume MA, Fini ME, Lovett DH, Spinale FG. PMID: 16766634.
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Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Am J Physiol Heart Circ Physiol. 2006 Oct; 291(4):H1838-46. Alfonso-Jaume MA, Bergman MR, Mahimkar R, Cheng S, Jin ZQ, Karliner JS, Lovett DH. PMID: 16699069.
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Intronic regulation mediates ischemia-induced MMP-2 transcription. Journal of Surgical Research. 2006 Feb 1; 130(2):184-185. Lee LJ, Lovett LD, Dahi DS. .
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Response element 1 reguliert die Expression der MMP-2 in der Wundheilung Ergebnisse aus dem transgenen Mausmodell. Chirurgisches Forum 2006. 2006 Jan 1; 35:9-11. Jansen JP, Hungol HM, Krott KE, Jansen JM, Lovett LD, Klinge KU, Mertens MP. .
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Intronic regulation of matrix metalloproteinase-2 revealed by in vivo transcriptional analysis in ischemia. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16345-50. Lee JG, Dahi S, Mahimkar R, Tulloch NL, Alfonso-Jaume MA, Lovett DH, Sarkar R. PMID: 16258061; PMCID: PMC1283457.
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Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility. Cardiovasc Res. 2006 Feb 15; 69(3):688-96. Wang GY, Bergman MR, Nguyen AP, Turcato S, Swigart PM, Rodrigo MC, Simpson PC, Karliner JS, Lovett DH, Baker AJ. PMID: 16183043.
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Differential transcriptional activation of matrix metalloproteinase-2 and membrane type-1 matrix metalloproteinase by experimental deep venous thrombosis and thrombin. J Vasc Surg. 2005 Sep; 42(3):539-45. Dahi S, Lee JG, Lovett DH, Sarkar R. PMID: 16171603.
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Interleukin-1 gene cluster polymorphisms predict risk of ESRD. Kidney Int. 2005 Jul; 68(1):278-84. Wetmore JB, Hung AM, Lovett DH, Sen S, Quershy O, Johansen KL. PMID: 15954918.
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Renin-angiotensin system gene polymorphisms predict the progression to renal insufficiency among Asians with lupus nephritis. Genes Immun. 2005 May; 6(3):217-24. Parsa A, Lovett DH, Peden EA, Zhu L, Seldin MF, Criswell LA. PMID: 15789057.
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The disintegrin domain of ADAM9: a ligand for multiple beta1 renal integrins. Biochem J. 2005 Jan 15; 385(Pt 2):461-8. Mahimkar RM, Visaya O, Pollock AS, Lovett DH. PMID: 15361064; PMCID: PMC1134717.
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Alloplastische Netzmaterialien induzieren die MMP-2 Promotoraktivität — Ergebnisse aus dem transgenen Mausmodell. Chirurgisches Forum 2005. 2005 Jan 1; 34:381-382. Jansen JP, Jansen JM, Hungol HM, Krott KE, Lovett LD, Mertens MP, Klinge KU. .
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Transcription factor YB-1 mediates DNA polymerase alpha gene expression. J Biol Chem. 2005 Mar 04; 280(9):7702-11. En-Nia A, Yilmaz E, Klinge U, Lovett DH, Stefanidis I, Mertens PR. PMID: 15615704.
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P53, YB-1 and the AP-1 family of transcription factors mediate MMP-2 transcription induced by skeletal muscle ischemia. Journal of the American College of Surgeons. 2004 Sep 1; 199(3):103. Sarkar SR, Lee LJ, Mahimkar MR, Lovett LD. .
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Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Biochem J. 2004 Jun 15; 380(Pt 3):735-47. Alfonso-Jaume MA, Mahimkar R, Lovett DH. PMID: 14979875; PMCID: PMC1224202.
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Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol. 2003 Jun; 162(6):1937-49. Cheng S, Lovett DH. PMID: 12759250; PMCID: PMC1868144.
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Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. J Biol Chem. 2003 Jun 06; 278(23):20490-9. Harendza S, Lovett DH, Panzer U, Lukacs Z, Kuhnl P, Stahl RA. PMID: 12657623.
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A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem J. 2003 Feb 01; 369(Pt 3):485-96. Bergman MR, Cheng S, Honbo N, Piacentini L, Karliner JS, Lovett DH. PMID: 12371906; PMCID: PMC1223099.
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The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells. FASEB J. 2003 Feb; 17(2):203-13. Pollock AS, Turck J, Lovett DH. PMID: 12554699.
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Tumour metastasis suppressor, nm23-beta, inhibits gelatinase A transcription by interference with transactivator Y-box protein-1 (YB-1). Biochem J. 2002 Sep 15; 366(Pt 3):807-16. Cheng S, Alfonso-Jaume MA, Mertens PR, Lovett DH. PMID: 12010125; PMCID: PMC1222814.
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Transcription factor Ets-1 regulates gelatinase a gene expression in mesangial cells. J Am Soc Nephrol. 2002 Jun; 13(6):1568-78. Reisdorff J, En-Nia A, Stefanidis I, Floege J, Lovett DH, Mertens PR. PMID: 12039986.
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Combinatorial interactions of p53, activating protein-2, and YB-1 with a single enhancer element regulate gelatinase A expression in neoplastic cells. J Biol Chem. 2002 Jul 12; 277(28):24875-82. Mertens PR, Steinmann K, Alfonso-Jaume MA, En-Nia A, Sun Y, Lovett DH. PMID: 11973333.
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Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem. 2002 May 24; 277(21):19206-12. Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC. PMID: 11884411.
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Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem. 2002 Feb 01; 277(5):3606-13. Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL. PMID: 11723120.
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The hematopoietic transcription factor PU.1 represses gelatinase A transcription in glomerular mesangial cells. J Biol Chem. 2000 Jun 30; 275(26):19552-9. Harendza S, Lovett DH, Stahl RA. PMID: 10867017.
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Identification, cellular distribution and potential function of the metalloprotease-disintegrin MDC9 in the kidney. J Am Soc Nephrol. 2000 Apr; 11(4):595-603. Mahimkar RM, Baricos WH, Visaya O, Pollock AS, Lovett DH. PMID: 10752518.
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YB-1 regulation of the human and rat gelatinase A genes via similar enhancer elements. J Am Soc Nephrol. 1999 Dec; 10(12):2480-7. Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH. PMID: 10589685.
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A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription. J Biol Chem. 1998 Dec 04; 273(49):32957-65. Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH. PMID: 9830047.
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Regulated expression of matrix metalloproteinases and TIMP in nephrogenesis. Dev Dyn. 1998 Sep; 213(1):121-9. Tanney DC, Feng L, Pollock AS, Lovett DH. PMID: 9733107.
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Glomerular mesangial cell-specific transactivation of matrix metalloproteinase 2 transcription is mediated by YB-1. J Biol Chem. 1997 Sep 05; 272(36):22905-12. Mertens PR, Harendza S, Pollock AS, Lovett DH. PMID: 9278454.
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Gelatinase A is a glomerular mesangial cell growth and differentiation factor. Kidney Int. 1997 May; 51(5):1397-400. Turck J, Pollock AS, Lovett DH. PMID: 9150450.
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The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):508-13. Stevenson FT, Turck J, Locksley RM, Lovett DH. PMID: 9012814; PMCID: PMC19543.
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Pharmacological inhibition of gelatinase B induction and tumor cell invasion. Int J Cancer. 1996 Aug 07; 67(4):523-31. McMillan JI, Weeks R, West JW, Bursten S, Rice GC, Lovett DH. PMID: 8759612.
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Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. J Biol Chem. 1996 Jun 21; 271(25):15074-83. Turck J, Pollock AS, Lee LK, Marti HP, Lovett DH. PMID: 8663054.
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Characterization of a glomerular epithelial cell metalloproteinase as matrix metalloproteinase-9 with enhanced expression in a model of membranous nephropathy. J Clin Invest. 1996 Feb 15; 97(4):1094-101. McMillan JI, Riordan JW, Couser WG, Pollock AS, Lovett DH. PMID: 8613533; PMCID: PMC507157.
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Tissue-specific enhancer-promoter interactions regulate high level constitutive expression of matrix metalloproteinase 2 by glomerular mesangial cells. J Biol Chem. 1995 Aug 11; 270(32):18786-96. Harendza S, Pollock AS, Mertens PR, Lovett DH. PMID: 7642529.
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Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest. 1995 Aug; 96(2):953-64. Lee LK, Meyer TW, Pollock AS, Lovett DH. PMID: 7635988; PMCID: PMC185283.
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Immunologic glomerular disease--new prospects for specific therapy. West J Med. 1994 May; 160(5):481-2. Lovett DH. PMID: 8048244; PMCID: PMC1022505.
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Role of oxidants and proteases in glomerular injury. Kidney Int. 1994 Feb; 45(2):352-9. Johnson RJ, Lovett D, Lehrer RI, Couser WG, Klebanoff SJ. PMID: 8164419.
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Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J Biol Chem. 1994 Jan 21; 269(3):2032-40. Gaire M, Magbanua Z, McDonnell S, McNeil L, Lovett DH, Matrisian LM. PMID: 8294454.
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Transforming growth factor-beta 1 stimulates glomerular mesangial cell synthesis of the 72-kd type IV collagenase. Am J Pathol. 1994 Jan; 144(1):82-94. Marti HP, Lee L, Kashgarian M, Lovett DH. PMID: 8291614; PMCID: PMC1887110.
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In vivo gene transfer, Koch's postulates, and renal disease. J Clin Invest. 1993 Dec; 92(6):2568. Johnson RJ, Lovett D. PMID: 8254014; PMCID: PMC288451.
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Asymmetric origins of the mature glomerular basement membrane. J Cell Physiol. 1993 Oct; 157(1):169-77. Lee LK, Pollock AS, Lovett DH. PMID: 8408235.
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The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7245-9. Stevenson FT, Bursten SL, Fanton C, Locksley RM, Lovett DH. PMID: 8346241; PMCID: PMC47113.
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Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Biochem J. 1993 Apr 15; 291 ( Pt 2):441-6. Marti HP, McNeil L, Davies M, Martin J, Lovett DH. PMID: 7916617; PMCID: PMC1132545.
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[Current aspects in the pathogenesis and therapy of glomerulonephritis: significance of glomerular metalloproteinases]. Schweiz Med Wochenschr. 1992 Nov 07; 122(45):1701-7. Marti HP, Lovett DH. PMID: 1439688.
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Myristyl acylation of the tumor necrosis factor alpha precursor on specific lysine residues. J Exp Med. 1992 Oct 01; 176(4):1053-62. Stevenson FT, Bursten SL, Locksley RM, Lovett DH. PMID: 1402651; PMCID: PMC2119375.
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Interleukin 1: the patterns of translation and intracellular distribution support alternative secretory mechanisms. J Cell Physiol. 1992 Aug; 152(2):223-31. Stevenson FT, Torrano F, Locksley RM, Lovett DH. PMID: 1639857.
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Molecular characterization of a low-molecular-mass matrix metalloproteinase secreted by glomerular mesangial cells as PUMP-1. Biochem J. 1992 Aug 01; 285 ( Pt 3):899-905. Marti HP, McNeil L, Thomas G, Davies M, Lovett DH. PMID: 1497627; PMCID: PMC1132880.
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Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am J Pathol. 1992 Jul; 141(1):85-98. Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG. PMID: 1321565; PMCID: PMC1886574.
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Expression of phosphoenolpyruvate carboxykinase (PEPCK) chimeras in renal epithelial cells. Retention of appropriate physiological responsiveness using enhancerless retroviral vectors. Biochem J. 1992 Jun 15; 284 ( Pt 3):725-32. Pollock AS, Lovett DH. PMID: 1377912; PMCID: PMC1132599.
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Glomerular epithelial cells secrete a glomerular basement membrane-degrading metalloproteinase. J Am Soc Nephrol. 1992 Mar; 2(9):1388-97. Johnson R, Yamabe H, Chen YP, Campbell C, Gordon K, Baker P, Lovett D, Couser WG. PMID: 1627762.
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Proteinases and glomerular matrix turnover. Kidney Int. 1992 Mar; 41(3):671-8. Davies M, Martin J, Thomas GJ, Lovett DH. PMID: 1573845.
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Lipid A activation of glomerular mesangial cells: mimicry of the bioactive lipid, phosphatidic acid. Am J Physiol. 1992 Feb; 262(2 Pt 1):C328-38. Bursten SL, Harris WE, Resch K, Lovett DH. PMID: 1539625.
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Interleukin-1 rapidly stimulates lysophosphatidate acyltransferase and phosphatidate phosphohydrolase activities in human mesangial cells. J Biol Chem. 1991 Nov 05; 266(31):20732-43. Bursten SL, Harris WE, Bomsztyk K, Lovett D. PMID: 1657935.
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Mesangial cell activation by bacterial endotoxin. Induction of rapid cytoskeletal reorganization and gene expression. Am J Pathol. 1991 Aug; 139(2):371-82. Bursten SL, Stevenson F, Torrano F, Lovett DH. PMID: 1867323; PMCID: PMC1886077.
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Proteinases and the glomerulus: their role in glomerular diseases. Klin Wochenschr. 1990 Nov 16; 68(22):1145-9. Davies M, Coles GA, Thomas GJ, Martin J, Lovett DH. PMID: 2280577.
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Particles from dialysis tubing stimulate interleukin-1 secretion by macrophages. Nephrol Dial Transplant. 1990; 5(3):208-13. Bommer J, Weinreich T, Lovett DH, Bouillon R, Ritz E, Gemsa D. PMID: 2113649.
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Human mesangial cells secrete a GBM-degrading neutral proteinase and a specific inhibitor. Kidney Int. 1989 Nov; 36(5):790-801. Martin J, Davies M, Thomas G, Lovett DH. PMID: 2559235.
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Characterization of the interleukin-1-induced tyrosine phosphorylation of a 41-kDa plasma membrane protein of the human tumor cell line K 562. Eur J Biochem. 1989 Mar 15; 180(2):343-50. Martin M, Lovett DH, Szamel M, Resch K. PMID: 2784384.
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Modulation of mesangial cell migration by extracellular matrix components. Inhibition by heparinlike glycosaminoglycans. Am J Pathol. 1988 Dec; 133(3):609-14. Person JM, Lovett DH, Raugi GJ. PMID: 3202119; PMCID: PMC1880797.
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Activation of glomerular mesangial cells by gram-negative bacterial cell wall components. Am J Pathol. 1988 Dec; 133(3):472-84. Lovett DH, Bursten SL, Gemsa D, Bessler W, Resch K, Ryan JL. PMID: 3059803; PMCID: PMC1880810.
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Insulin and insulin-like growth factor I binding to cultured rat glomerular mesangial cells. Endocrinology. 1988 Nov; 123(5):2432-9. Abrass CK, Raugi GJ, Gabourel LS, Lovett DH. PMID: 3049050.
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Acylation of monocyte and glomerular mesangial cell proteins. Myristyl acylation of the interleukin 1 precursors. J Clin Invest. 1988 Nov; 82(5):1479-88. Bursten SL, Locksley RM, Ryan JL, Lovett DH. PMID: 3263392; PMCID: PMC442712.
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Cell cycle-dependent interleukin 1 gene expression by cultured glomerular mesangial cells. J Clin Invest. 1988 Jul; 82(1):115-22. Lovett DH, Larsen A. PMID: 3260603; PMCID: PMC303484.
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Interleukin 1 and the glomerular mesangium. III. IL-1-dependent stimulation of mesangial cell protein kinase activity. Kidney Int. 1988 Jul; 34(1):26-35. Lovett DH, Martin M, Bursten S, Szamel M, Gemsa D, Resch K. PMID: 3262785.
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The purification and characterization of a glomerular-basement-membrane-degrading neutral proteinase from rat mesangial cells. Biochem J. 1988 Apr 15; 251(2):419-25. Davies M, Thomas GJ, Martin J, Lovett DH. PMID: 2840892; PMCID: PMC1149019.
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Interleukin I and the glomerular mesangium. II. Monokine stimulation of mesangial cell prostanoid secretion. Am J Pathol. 1987 Dec; 129(3):543-51. Lovett DH, Resch K, Gemsa D. PMID: 3322024; PMCID: PMC1899818.
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Thrombospondin secretion by cultured human glomerular mesangial cells. Am J Pathol. 1987 Nov; 129(2):364-72. Raugi GJ, Lovett DH. PMID: 3314532; PMCID: PMC1899722.
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Activation of glomerular mesangial cells by the terminal membrane attack complex of complement. J Immunol. 1987 Apr 15; 138(8):2473-80. Lovett DH, Haensch GM, Goppelt M, Resch K, Gemsa D. PMID: 3494069.
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Mesangial cell hillocks. Nodular foci of exaggerated growth of cells and matrix in prolonged culture. Am J Pathol. 1986 Oct; 125(1):130-40. Sterzel RB, Lovett DH, Foellmer HG, Perfetto M, Biemesderfer D, Kashgarian M. PMID: 3535527; PMCID: PMC1888434.
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The receptor for interleukin 1 in plasma membranes of the human leukemia cell K 562: biological and biochemical characterization. Immunobiology. 1986 Sep; 172(3-5):336-45. Resch K, Martin M, Lovett DH, Kyas U, Gemsa D. PMID: 2948903.
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Cell culture approaches to the analysis of glomerular inflammation. Kidney Int. 1986 Aug; 30(2):246-54. Lovett DH, Sterzel RB. PMID: 3531678.
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Enhancement of glomerular mesangial cell neutral proteinase secretion by macrophages: role of interleukin 1. J Immunol. 1986 Jul 15; 137(2):525-9. Martin J, Lovett DH, Gemsa D, Sterzel RB, Davies M. PMID: 3013993.
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Interleukin 1 and the glomerular mesangium. I. Purification and characterization of a mesangial cell-derived autogrowth factor. J Immunol. 1986 May 15; 136(10):3700-5. Lovett DH, Szamel M, Ryan JL, Sterzel RB, Gemsa D, Resch K. PMID: 3486219.
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Interleukin 1 induces specific phosphorylation of a 41 kDa plasma membrane protein from the human tumor cell line K 562. Immunobiology. 1986 Apr; 171(3):165-9. Martin M, Lovett D, Resch K. PMID: 3486814.
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Macrophage cytotoxicity: interleukin 1 as a mediator of tumor cytostasis. J Immunol. 1986 Jan; 136(1):340-7. Lovett D, Kozan B, Hadam M, Resch K, Gemsa D. PMID: 2999248.
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Measurement of interleukin-1 by growth inhibition of the human tumor cell K562; receptor studies. Lymphokine Res. 1986; 5 Suppl 1:S81-6. Resch K, Martin M, Lovett DH, Gemsa D. PMID: 2946904.
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Release of Prostaglandins and Modulation of Leukocyte Functions. Advances in Immunopharmacology. 1986 Jan 1; 127-136. GEMSA GD, NAIN NM, HÄNSCH HG, LOVETT LD, KRAMMER KP, RESCH RK. .
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Studies on the mechanism whereby cyclosporin A inhibits T-lymphocyte activation. Immunobiology. 1985 Feb; 169(1):83-96. Stoeck M, Wildhagen K, Szamel M, Lovett D, Resch K. PMID: 2580777.
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Production of an endogenous pyrogen by glomerular mesangial cells. J Immunol. 1985 Feb; 134(2):670-2. Lovett DH, Sterzel RB, Ryan JL, Atkins E. PMID: 3871212.
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Stimulation of rat mesangial cell proliferation by macrophage interleukin 1. J Immunol. 1983 Dec; 131(6):2830-6. Lovett DH, Ryan JL, Sterzel RB. PMID: 6605992.
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A thymocyte-activating factor derived from glomerular mesangial cells. J Immunol. 1983 Apr; 130(4):1796-801. Lovett DH, Ryan JL, Sterzel RB. PMID: 6601138.
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Neutral proteinase activity produced in vitro by cells of the glomerular mesangium. Kidney Int. 1983 Feb; 23(2):342-9. Lovett DH, Sterzel RB, Kashgarian M, Ryan JL. PMID: 6405073.
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The mesangium and glomerulonephritis. Klin Wochenschr. 1982 Sep 15; 60(18):1077-94. Sterzel RB, Lovett DH, Stein HD, Kashgarian M. PMID: 7144055.
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Lysosomal enzymes in glomerular cells of the rat. Am J Pathol. 1982 May; 107(2):161-6. Lovett DH, Ryan JL, Kashgarian M, Sterzel RB. PMID: 6282126; PMCID: PMC1916002.
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Angioimmunoblastic lymphadenopathy evolution to a Burkitt-like lymphoma. Am J Med. 1979 Aug; 67(2):317-24. Mazur EM, Lovett DH, Enriquez RE, Breg WR, Papac RJ. PMID: 313708.
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