…16I T24506G S982A G24914C D1118H Orf8 C27972T Q27stop G28048T R52I A28111G Y73C 28280 GAT->CTA D3L C28977T S235F Outside of spike, the ORF8 Q27stop mutation truncates the ORF8 protein or renders it inactive and thus allows further downstream mutations to accrue. Early on during t…