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Omnidirectional 3D Printing of Anisotropic Nanofibrous Peptide Hydrogels. bioRxiv. 2025 Nov 08. Farsheed AC, Makhoul JT, Chew-Martinez D, Maldonado E, Liu J, Yu LT, Gorostieta-Salas E, Jones JR, Gage FH, Hartgerink JD. PMID: 41278881; PMCID: PMC12637642.
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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2025 Oct 10; 26(1):60. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. PMID: 41073908; PMCID: PMC12512934.
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Differential effects of lithium on metabolic dysfunctions in astrocytes derived from bipolar disorder patients. Mol Psychiatry. 2025 Dec; 30(12):5833-5848. Baek GH, Kim D, Son G, Do H, Yeon GB, Lee MJ, Ji M, Son JH, Ju M, Ahn I, Kang CS, Lee H, Choi S, Suh JM, Seo J, Gage FH, Paik MJ, Park Y, Kim DS, Han J. PMID: 40847005; PMCID: PMC12602366.
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ROS-dependent localization of glycolytic enzymes to mitochondria. Redox Biol. 2025 10; 86:103812. Esparza-Moltó PB, Goswami AV, Bozkurt S, Münch C, Newman LE, Moyzis AG, Rojas GR, Guan D, Jones JR, Gage FH, Shadel GS. PMID: 40803248; PMCID: PMC12359183.
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CK2 inhibition suppresses glial inflammation in the brain. bioRxiv. 2025 Aug 07. Da Silva IIN, Ramirez D, Parylak SL, Wallace LA, Tucker JK, Erberich JM, Katariya R, McDonald AH, Gallina IS, Tucker AL, Burgado J, Jaeger BN, Barron JJ, Pratt JM, Pena M, Racha V, Lim CK, Fernandes S, Benassi S, Randolph-Moore L, Vadodaria KC, Marchetto MC, Allen NJ, Gage FH. PMID: 41030967; PMCID: PMC12478410.
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Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity. Bioorg Med Chem. 2025 Sep 01; 127:118196. Tucker JK, Da Silva IIN, Gage FH. PMID: 40367913.
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Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice. iScience. 2025 May 16; 28(5):112354. Liu YN, Wang QW, Lu SY, Shen W, Guo C, Xing Z, Li C, Sun S, Sui SF, Mi S, Gage FH, Yao J. PMID: 40330888; PMCID: PMC12053657.
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New neurons are born in the adult human brain. Nat Med. 2025 Feb; 31(2):356-357. Gage FH. PMID: 39915679.
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Adult Neurogenesis in the Human Dentate Gyrus. Hippocampus. 2025 Jan; 35(1):e23655. Gage FH. PMID: 39648699.
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A framework for neural organoids, assembloids and transplantation studies. Nature. 2025 Mar; 639(8054):315-320. Pa?ca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. PMID: 39653126.
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miR-124 coordinates metabolic regulators acting at early stages of human neurogenesis. Commun Biol. 2024 Oct 25; 7(1):1393. Son G, Na Y, Kim Y, Son JH, Clemenson GD, Schafer ST, Yoo JY, Parylak SL, Paquola A, Do H, Kim D, Ahn I, Ju M, Kang CS, Ju Y, Jung E, McDonald AH, Park Y, Kim G, Paik SB, Hur J, Kim J, Han YM, Lee SH, Gage FH, Kim JS, Han J. PMID: 39455851; PMCID: PMC11511827.
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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. Science. 2024 08 23; 385(6711):eabm6131. Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Wang Q, Mhatre SD, Uenaka T, Crapser J, Conley T, Ennerfelt H, Jung YJ, Liu L, Prasad P, Jenkins BC, Ay YA, Matrongolo M, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Yang T, Ullian EM, Serrano GE, Beach TG, Wernig M, Rabinowitz JD, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. PMID: 39172838; PMCID: PMC12313320.
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Modeling Alzheimer's disease using human cell derived brain organoids and 3D models. Front Neurosci. 2024; 18:1434945. Fernandes S, Revanna J, Pratt J, Hayes N, Marchetto MC, Gage FH. PMID: 39156632; PMCID: PMC11328153.
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Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies. bioRxiv. 2024 Jun 28. Minhas PS, Jones JR, Latif-Hernandez A, Sugiura Y, Durairaj AS, Uenaka T, Wang Q, Mhatre SD, Liu L, Conley T, Ennerfelt H, Jung YJ, Prasad P, Jenkins BC, Goodman R, Newmeyer T, Heard K, Kang A, Wilson EN, Ullian EM, Serrano GE, Beach TG, Rabinowitz JD, Wernig M, Suematsu M, Longo FM, McReynolds MR, Gage FH, Andreasson KI. PMID: 38979192; PMCID: PMC11230169.
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Neuronal senescence may drive brain aging. Science. 2024 06 28; 384(6703):1404-1406. Herdy JR, Mertens J, Gage FH. PMID: 38935713; PMCID: PMC11737875.
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Protocol for the San Diego Nathan Shock Center Clinical Cohort: a new resource for studies of human aging. BMJ Open. 2024 06 25; 14(6):e082659. Phang HJ, Heimler SR, Scandalis LM, Wing D, Moran R, Nichols JF, Moreno D, Shadel GS, Gage FH, Molina AJA. PMID: 38925692; PMCID: PMC11202663.
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High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer. Nat Commun. 2024 Jun 18; 15(1):5149. Schmidt TT, Tyer C, Rughani P, Haggblom C, Jones JR, Dai X, Frazer KA, Gage FH, Juul S, Hickey S, Karlseder J. PMID: 38890299; PMCID: PMC11189484.
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Upregulated ECM genes and increased synaptic activity in Parkinson's human DA neurons with PINK1/ PRKN mutations. NPJ Parkinsons Dis. 2024 May 18; 10(1):103. Tripathi U, Rosh I, Ben Ezer R, Nayak R, Hussein Y, Choudhary A, Djamus J, Manole A, Houlden H, Gage FH, Stern S. PMID: 38762512; PMCID: PMC11102563.
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission. Mol Psychiatry. 2024 Oct; 29(10):3208-3222. Stern S, Zhang L, Wang M, Wright R, Rosh I, Hussein Y, Stern T, Choudhary A, Tripathi U, Reed P, Sadis H, Nayak R, Shemen A, Agarwal K, Cordeiro D, Peles D, Hang Y, Mendes APD, Baul TD, Roth JG, Coorapati S, Boks MP, McCombie WR, Hulshoff Pol H, Brennand KJ, Réthelyi JM, Kahn RS, Marchetto MC, Gage FH. PMID: 38704507; PMCID: PMC11449799.
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Lifelong persistence of nuclear RNAs in the mouse brain. Science. 2024 04 05; 384(6691):53-59. Zocher S, McCloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer MW, Toda T. PMID: 38574132; PMCID: PMC7615865.
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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain. Nat Biotechnol. 2025 Jan; 43(1):52-62. Wang M, Zhang L, Novak SW, Yu J, Gallina IS, Xu LL, Lim CK, Fernandes S, Shokhirev MN, Williams AE, Saxena MD, Coorapati S, Parylak SL, Quintero C, Molina E, Andrade LR, Manor U, Gage FH. PMID: 38418648; PMCID: PMC11349933.
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Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson's disease patients. NPJ Parkinsons Dis. 2024 Feb 19; 10(1):38. Rosh I, Tripathi U, Hussein Y, Rike WA, Djamus J, Shklyar B, Manole A, Houlden H, Winkler J, Gage FH, Stern S. PMID: 38374278; PMCID: PMC10876637.
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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Rep. 2024 02 27; 43(2):113774. Toda T, Bedrosian TA, Schafer ST, Cuoco MS, Linker SB, Ghassemzadeh S, Mitchell L, Whiteley JT, Novaresi N, McDonald AH, Gallina IS, Yoon H, Hester ME, Pena M, Lim C, Suljic E, AlFatah Mansour A, Boulard M, Parylak SL, Gage FH. PMID: 38349791; PMCID: PMC10948021.
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Tyro3 promotes the maturation of glutamatergic synapses. Front Neurosci. 2024; 18:1327423. Miao S, Fourgeaud L, Burrola PG, Stern S, Zhang Y, Happonen KE, Novak SW, Gage FH, Lemke G. PMID: 38410160; PMCID: PMC10894971.
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Human iN neuronal model of schizophrenia displays dysregulation of chromogranin B and related neuropeptide transmitter signatures. Mol Psychiatry. 2024 May; 29(5):1440-1449. Podvin S, Jones J, Kang A, Goodman R, Reed P, Lietz CB, Then J, Lee KC, Eyler LT, Jeste DV, Gage FH, Hook V. PMID: 38302561; PMCID: PMC11189816.
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NGLY1 mutations cause protein aggregation in human neurons. Cell Rep. 2023 12 26; 42(12):113466. Manole A, Wong T, Rhee A, Novak S, Chin SM, Tsimring K, Paucar A, Williams A, Newmeyer TF, Schafer ST, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo AM, Andrade L, Manor U, Lee K, Jones JR, Stern S, Marchetto MC, Gage FH. PMID: 38039131; PMCID: PMC10826878.
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Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases. Sci Data. 2023 11 20; 10(1):813. Garrison MA, Jang Y, Bae T, Cherskov A, Emery SB, Fasching L, Jones A, Moldovan JB, Molitor C, Pochareddy S, Peters MA, Shin JH, Wang Y, Yang X, Akbarian S, Chess A, Gage FH, Gleeson JG, Kidd JM, McConnell M, Mills RE, Moran JV, Park PJ, Sestan N, Urban AE, Vaccarino FM, Walsh CA, Weinberger DR, Wheelan SJ, Abyzov A, BSMN Consortium. PMID: 37985666; PMCID: PMC10662356.
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Immunoglobulin genes expressed in lymphoblastoid cell lines discern and predict lithium response in bipolar disorder patients. Mol Psychiatry. 2023 10; 28(10):4280-4293. Mizrahi L, Choudhary A, Ofer P, Goldberg G, Milanesi E, Kelsoe JR, Gurwitz D, Alda M, Gage FH, Stern S. PMID: 37488168; PMCID: PMC10827667.
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Neural cell state shifts and fate loss in ageing and age-related diseases. Nat Rev Neurol. 2023 07; 19(7):434-443. Traxler L, Lucciola R, Herdy JR, Jones JR, Mertens J, Gage FH. PMID: 37268723; PMCID: PMC10478103.
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An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell. 2023 05 11; 186(10):2111-2126.e20. Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. PMID: 37172564; PMCID: PMC10284271.
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Novel correlative analysis identifies multiple genomic variations impacting ASD with macrocephaly. Hum Mol Genet. 2023 05 05; 32(10):1589-1606. Fu C, Ngo J, Zhang S, Lu L, Miron A, Schafer S, Gage FH, Jin F, Schumacher FR, Wynshaw-Boris A. PMID: 36519762; PMCID: PMC10162433.
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Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. Eur Neuropsychopharmacol. 2023 09; 74:1-14. Mishra HK, Wei H, Rohr KE, Ko I, Nievergelt CM, Maihofer AX, Shilling PD, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye M, Gage F, Gershon E, McInnis MG, Nurnberger J, Oedegaard KJ, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 37126998; PMCID: PMC11801370.
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Neural Organoids and the Quest to Understand and Treat Psychiatric Disease. Biol Psychiatry. 2023 04 01; 93(7):588-589. Arlotta P, Gage FH. PMID: 36889858.
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Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Mol Psychiatry. 2024 01; 29(1):6-19. Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Øedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR. PMID: 36991131; PMCID: PMC11078741.
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Adult neurogenesis in the hippocampus. Hippocampus. 2023 04; 33(4):269-270. Kempermann G, Song H, Gage FH. PMID: 36912499; PMCID: PMC11175592.
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Neuronal activity-related transcription is blunted in immature compared to mature dentate granule cells. Hippocampus. 2023 04; 33(4):412-423. Parylak SL, Qiu F, Linker SB, Gallina IS, Lim CK, Preciado D, McDonald AH, Zhou X, Gage FH. PMID: 36811254; PMCID: PMC10985790.
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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy. Neurosci Lett. 2023 02 16; 797:137080. Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. PMID: 36657633; PMCID: PMC9974759.
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Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids. Biol Psychiatry. 2023 04 01; 93(7):616-621. Wang M, Gage FH, Schafer ST. PMID: 36739209; PMCID: PMC10662460.
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Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex. Nat Commun. 2022 12 26; 13(1):7945. Wilson MN, Thunemann M, Liu X, Lu Y, Puppo F, Adams JW, Kim JH, Ramezani M, Pizzo DP, Djurovic S, Andreassen OA, Mansour AA, Gage FH, Muotri AR, Devor A, Kuzum D. PMID: 36572698; PMCID: PMC9792589.
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Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 2022 12 01; 29(12):1637-1652.e6. Herdy JR, Traxler L, Agarwal RK, Karbacher L, Schlachetzki JCM, Boehnke L, Zangwill D, Galasko D, Glass CK, Mertens J, Gage FH. PMID: 36459967; PMCID: PMC10093780.
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Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. NPJ Parkinsons Dis. 2022 Oct 18; 8(1):134. van den Hurk M, Lau S, Marchetto MC, Mertens J, Stern S, Corti O, Brice A, Winner B, Winkler J, Gage FH, Bardy C. PMID: 36258029; PMCID: PMC9579158.
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Human-specific regulation of neural maturation identified by cross-primate transcriptomics. Curr Biol. 2022 11 21; 32(22):4797-4807.e5. Linker SB, Narvaiza I, Hsu JY, Wang M, Qiu F, Mendes APD, Oefner R, Kottilil K, Sharma A, Randolph-Moore L, Mejia E, Santos R, Marchetto MC, Gage FH. PMID: 36228612.
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A nomenclature consensus for nervous system organoids and assembloids. Nature. 2022 09; 609(7929):907-910. Pa?ca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Muotri AR, Park IH, Reiner O, Song H, Studer L, Temple S, Testa G, Treutlein B, Vaccarino FM. PMID: 36171373; PMCID: PMC10571504.
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Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 09 06; 34(9):1248-1263.e6. Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. PMID: 35987203; PMCID: PMC9458870.
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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. NPJ Parkinsons Dis. 2022 Aug 10; 8(1):103. Stern S, Lau S, Manole A, Rosh I, Percia MM, Ben Ezer R, Shokhirev MN, Qiu F, Schafer S, Mansour AA, Mangan KP, Stern T, Ofer P, Stern Y, Diniz Mendes AP, Djamus J, Moore LR, Nayak R, Laufer SH, Aicher A, Rhee A, Wong TL, Nguyen T, Linker SB, Winner B, Freitas BC, Jones E, Sagi I, Bardy C, Brice A, Winkler J, Marchetto MC, Gage FH. PMID: 35948563; PMCID: PMC9365794.
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Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability. Science. 2022 07 29; 377(6605):511-517. Bae T, Fasching L, Wang Y, Shin JH, Suvakov M, Jang Y, Norton S, Dias C, Mariani J, Jourdon A, Wu F, Panda A, Pattni R, Chahine Y, Yeh R, Roberts RC, Huttner A, Kleinman JE, Hyde TM, Straub RE, Walsh CA, Brain Somatic Mosaicism Network§, Urban AE, Leckman JF, Weinberger DR, Vaccarino FM, Abyzov A. PMID: 35901164; PMCID: PMC9420557.
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Methods for culturing adult CNS neurons reveal a CNS conditioning effect. Cell Rep Methods. 2022 07 18; 2(7):100255. van Niekerk EA, Kawaguchi R, Marques de Freria C, Groeniger K, Marchetto MC, Dupraz S, Bradke F, Geschwind DH, Gage FH, Tuszynski MH. PMID: 35880023; PMCID: PMC9308166.
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Dynamic Interrogation of Stochastic Transcriptome Trajectories Using Disease Associated Genes Reveals Distinct Origins of Neurological and Psychiatric Disorders. Front Neurosci. 2022; 16:884707. Bermperidis T, Schafer S, Gage FH, Sejnowski T, Torres EB. PMID: 35720720; PMCID: PMC9201694.
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Oleic acid regulates hippocampal neurogenesis as a TLX ligand. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2203038119. Shi Y, Evans RM, Gage FH. PMID: 35344400; PMCID: PMC9169763.
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Chronic cortisol differentially impacts stem cell-derived astrocytes from major depressive disorder patients. Transl Psychiatry. 2021 11 30; 11(1):608. Heard KJ, Shokhirev MN, Becronis C, Fredlender C, Zahid N, Le AT, Ji Y, Skime M, Nelson T, Hall-Flavin D, Weinshilboum R, Gage FH, Vadodaria KC. PMID: 34848679; PMCID: PMC8632962.
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Adult neurogenesis in neurological diseases. Science. 2021 Nov 26; 374(6571):1049-1050. Gage FH. PMID: 34822282.
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The San Diego Nathan Shock Center: tackling the heterogeneity of aging. Geroscience. 2021 10; 43(5):2139-2148. Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH, Hah N, Hansen M, Hetzer MW, Molina AJA, Manor U, Marek K, O'Keefe DD, Pinto AFM, Sacco A, Sharpee TO, Shokriev MN, Zambetti S. PMID: 34370163; PMCID: PMC8599742.
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The role of retrotransposable elements in ageing and age-associated diseases. Nature. 2021 08; 596(7870):43-53. Gorbunova V, Seluanov A, Mita P, McKerrow W, Fenyö D, Boeke JD, Linker SB, Gage FH, Kreiling JA, Petrashen AP, Woodham TA, Taylor JR, Helfand SL, Sedivy JM. PMID: 34349292; PMCID: PMC8600649.
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AAV ablates neurogenesis in the adult murine hippocampus. Elife. 2021 07 14; 10. Johnston S, Parylak SL, Kim S, Mac N, Lim C, Gallina I, Bloyd C, Newberry A, Saavedra CD, Novak O, Gonçalves JT, Gage FH, Shtrahman M. PMID: 34259630; PMCID: PMC8331179.
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The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 06 08; 118(23). Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. PMID: 34083437; PMCID: PMC8201764.
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Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho. Mol Psychiatry. 2021 11; 26(11):6365-6379. Dias GP, Murphy T, Stangl D, Ahmet S, Morisse B, Nix A, Aimone LJ, Aimone JB, Kuro-O M, Gage FH, Thuret S. PMID: 34031536; PMCID: PMC8760057.
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To eat, or not to eat, that is the question: Neural stem cells escape phagocytosis in autism with macrocephaly. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). Schafer ST, Gage FH. PMID: 33883269; PMCID: PMC8126768.
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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients. Cell Stem Cell. 2021 09 02; 28(9):1533-1548.e6. Mertens J, Herdy JR, Traxler L, Schafer ST, Schlachetzki JCM, Böhnke L, Reid DA, Lee H, Zangwill D, Fernandes DP, Agarwal RK, Lucciola R, Zhou-Yang L, Karbacher L, Edenhofer F, Stern S, Horvath S, Paquola ACM, Glass CK, Yuan SH, Ku M, Szücs A, Goldstein LSB, Galasko D, Gage FH. PMID: 33910058; PMCID: PMC8423435.
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Incorporation of a nucleoside analog maps genome repair sites in postmitotic human neurons. Science. 2021 04 02; 372(6537):91-94. Reid DA, Reed PJ, Schlachetzki JCM, Nitulescu II, Chou G, Tsui EC, Jones JR, Chandran S, Lu AT, McClain CA, Ooi JH, Wang TW, Lana AJ, Linker SB, Ricciardulli AS, Lau S, Schafer ST, Horvath S, Dixon JR, Hah N, Glass CK, Gage FH. PMID: 33795458; PMCID: PMC9179101.
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Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes. Mol Psychiatry. 2021 07; 26(7):2753-2763. Nakatsuka N, Heard KJ, Faillétaz A, Momotenko D, Vörös J, Gage FH, Vadodaria KC. PMID: 33767349; PMCID: PMC9997689.
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Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Mol Psychiatry. 2021 07; 26(7):3383-3394. Mishra HK, Ying NM, Luis A, Wei H, Nguyen M, Nakhla T, Vandenburgh S, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Frye MA, Gage FH, Gershon ES, McInnis MG, Nievergelt CM, Nurnberger JI, Shilling PD, Oedegaard KJ, Zandi PP, Pharmacogenomics of Bipolar Disorder Study, Kelsoe JR, Welsh DK, McCarthy MJ. PMID: 33674753; PMCID: PMC8418615.
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Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes. Stem Cell Reports. 2021 04 13; 16(4):825-835. Vadodaria KC, Mendes APD, Mei A, Racha V, Erikson G, Shokhirev MN, Oefner R, Heard KJ, McCarthy MJ, Eyler L, Kelsoe JR, Santos R, Marchetto MC, Gage FH. PMID: 33667413; PMCID: PMC8072028.
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The When and Where: Molecular and Cellular Convergence in Autism. Biol Psychiatry. 2021 03 01; 89(5):419-420. Schafer ST, Gage FH. PMID: 33541523.
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Cytoplasmic synthesis of endogenous Alu complementary DNA via reverse transcription and implications in age-related macular degeneration. Proc Natl Acad Sci U S A. 2021 02 09; 118(6). Fukuda S, Varshney A, Fowler BJ, Wang SB, Narendran S, Ambati K, Yasuma T, Magagnoli J, Leung H, Hirahara S, Nagasaka Y, Yasuma R, Apicella I, Pereira F, Makin RD, Magner E, Liu X, Sun J, Wang M, Baker K, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Pandey A, Pandya L, Cummings T, Banerjee D, Huang P, Yerramothu P, Tolstonog GV, Held U, Erwin JA, Paquola ACM, Herdy JR, Ogura Y, Terasaki H, Oshika T, Darwish S, Singh RK, Mozaffari S, Bhattarai D, Kim KB, Hardin JW, Bennett CL, Hinton DR, Hanson TE, Röver C, Parang K, Kerur N, Liu J, Werner BC, Sutton SS, Sadda SR, Schumann GG, Gelfand BD, Gage FH, Ambati J. PMID: 33526699; PMCID: PMC8017980.
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Deficient LEF1 expression is associated with lithium resistance and hyperexcitability in neurons derived from bipolar disorder patients. Mol Psychiatry. 2021 06; 26(6):2440-2456. Santos R, Linker SB, Stern S, Mendes APD, Shokhirev MN, Erikson G, Randolph-Moore L, Racha V, Kim Y, Kelsoe JR, Bang AG, Alda M, Marchetto MC, Gage FH. PMID: 33398088; PMCID: PMC9129103.
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Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 02 01; 40(3):e105819. Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. PMID: 33300615; PMCID: PMC7849303.
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Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31438-31447. Wang QW, Lu SY, Liu YN, Chen Y, Wei H, Shen W, Chen YF, Fu CL, Wang YH, Dai A, Huang X, Gage FH, Xu Q, Yao J. PMID: 33229564; PMCID: PMC7733786.
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Identification of bona fide B2 SINE retrotransposon transcription through single-nucleus RNA-seq of the mouse hippocampus. Genome Res. 2020 11; 30(11):1643-1654. Linker SB, Randolph-Moore L, Kottilil K, Qiu F, Jaeger BN, Barron J, Gage FH. PMID: 33122305; PMCID: PMC7605253.
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Inositol monophosphatase 1 (IMPA1) mutation in intellectual disability patients impairs neurogenesis but not gliogenesis. Mol Psychiatry. 2021 07; 26(7):3558-3571. Figueiredo T, Mendes APD, Moreira DP, Goulart E, Oliveira D, Kobayashi GS, Stern S, Kok F, Marchetto MC, Santos R, Gage FH, Zatz M. PMID: 32839513.
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Motoneuron expression profiling identifies an association between an axonal splice variant of HDGF-related protein 3 and peripheral myelination. J Biol Chem. 2020 08 21; 295(34):12233-12246. Kerman BE, Genoud S, Kurt Vatandaslar B, Denli AM, Georges Ghosh S, Xu X, Yeo GW, Aimone JB, Gage FH. PMID: 32647008; PMCID: PMC7443494.
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Cellular complexity in brain organoids: Current progress and unsolved issues. Semin Cell Dev Biol. 2021 03; 111:32-39. Mansour AA, Schafer ST, Gage FH. PMID: 32499191.
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Modeling Brain Disorders Using Induced Pluripotent Stem Cells. Cold Spring Harb Perspect Biol. 2020 06 01; 12(6). Vadodaria KC, Jones JR, Linker S, Gage FH. PMID: 31767646; PMCID: PMC7263088.
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Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):10055-10066. Wenderski W, Wang L, Krokhotin A, Walsh JJ, Li H, Shoji H, Ghosh S, George RD, Miller EL, Elias L, Gillespie MA, Son EY, Staahl BT, Baek ST, Stanley V, Moncada C, Shipony Z, Linker SB, Marchetto MCN, Gage FH, Chen D, Sultan T, Zaki MS, Ranish JA, Miyakawa T, Luo L, Malenka RC, Crabtree GR, Gleeson JG. PMID: 32312822; PMCID: PMC7211998.
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Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids. Cell Rep Med. 2020 04 21; 1(1):100002. Sun G, Chiuppesi F, Chen X, Wang C, Tian E, Nguyen J, Kha M, Trinh D, Zhang H, Marchetto MC, Song H, Ming GL, Gage FH, Diamond DJ, Wussow F, Shi Y. PMID: 33205055; PMCID: PMC7659592.
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Author Correction: Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2020 03; 17(3):353. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Belmonte JCI. PMID: 32034376.
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Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4392-4399. Shen W, Wang QW, Liu YN, Marchetto MC, Linker S, Lu SY, Chen Y, Liu C, Guo C, Xing Z, Shi W, Kelsoe JR, Alda M, Wang H, Zhong Y, Sui SF, Zhao M, Yang Y, Mi S, Cao L, Gage FH, Yao J. PMID: 32041882; PMCID: PMC7049155.
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A Physiological Instability Displayed in Hippocampal Neurons Derived From Lithium-Nonresponsive Bipolar Disorder Patients. Biol Psychiatry. 2020 07 15; 88(2):150-158. Stern S, Sarkar A, Galor D, Stern T, Mei A, Stern Y, Mendes APD, Randolph-Moore L, Rouleau G, Bang AG, Santos R, Alda M, Marchetto MC, Gage FH. PMID: 32278494; PMCID: PMC10871148.
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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability. Cell Stem Cell. 2020 02 06; 26(2):221-233.e6. Wang M, Wei PC, Lim CK, Gallina IS, Marshall S, Marchetto MC, Alt FW, Gage FH. PMID: 32004479; PMCID: PMC7175642.
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Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis. Cell Stem Cell. 2020 02 06; 26(2):187-204.e10. Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN. PMID: 31956038; PMCID: PMC9628766.
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Brain cell type-specific enhancer-promoter interactome maps and disease-risk association. Science. 2019 11 29; 366(6469):1134-1139. Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK. PMID: 31727856; PMCID: PMC7028213.
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Mechanisms Underlying the Hyperexcitability of CA3 and Dentate Gyrus Hippocampal Neurons Derived From Patients With Bipolar Disorder. Biol Psychiatry. 2020 07 15; 88(2):139-149. Stern S, Sarkar A, Stern T, Mei A, Mendes APD, Stern Y, Goldberg G, Galor D, Nguyen T, Randolph-Moore L, Kim Y, Rouleau G, Bang A, Alda M, Santos R, Marchetto MC, Gage FH. PMID: 31732108; PMCID: PMC7108962.
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Dynamical Electrical Complexity Is Reduced during Neuronal Differentiation in Autism Spectrum Disorder. Stem Cell Reports. 2019 09 10; 13(3):474-484. Amatya DN, Linker SB, Mendes APD, Santos R, Erikson G, Shokhirev MN, Zhou Y, Sharpee T, Gage FH, Marchetto MC, Kim Y. PMID: 31474529; PMCID: PMC6739708.
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An Epilepsy-Associated KCNT1 Mutation Enhances Excitability of Human iPSC-Derived Neurons by Increasing Slack KNa Currents. J Neurosci. 2019 09 11; 39(37):7438-7449. Quraishi IH, Stern S, Mangan KP, Zhang Y, Ali SR, Mercier MR, Marchetto MC, McLachlan MJ, Jones EM, Gage FH, Kaczmarek LK. PMID: 31350261; PMCID: PMC6759030.
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Prediction of Response to Drug Therapy in Psychiatric Disorders. Focus (Am Psychiatr Publ). 2019 Jul; 17(3):294-307. Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 32015721; PMCID: PMC6996058.
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Corrigendum: Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2019; 12:150. van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 31244603; PMCID: PMC6580186.
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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2019 Jun 06; 24(6):1006. Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 31173705.
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Adult neurogenesis in mammals. Science. 2019 May 31; 364(6443):827-828. Gage FH. PMID: 31147506.
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Modeling neuropsychiatric disorders using human induced pluripotent stem cells. Protein Cell. 2020 01; 11(1):45-59. Wang M, Zhang L, Gage FH. PMID: 31134525; PMCID: PMC6949328.
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Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons. Elife. 2019 05 17; 8. Herdy J, Schafer S, Kim Y, Ansari Z, Zangwill D, Ku M, Paquola A, Lee H, Mertens J, Gage FH. PMID: 31099332; PMCID: PMC6524968.
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Nerve cells from the brain invade prostate tumours. Nature. 2019 05; 569(7758):637-638. Schafer ST, Gage FH. PMID: 31138915.
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Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Mol Neuropsychiatry. 2019 Apr; 5(2):115-124. Nudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, Nurnberger JI, Oedegaard KJ, Shekhtman T, Zandi PP, Kelsoe JR, McCarthy MJ. PMID: 31192224; PMCID: PMC6528084.
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Altered serotonergic circuitry in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):808-818. Vadodaria KC, Ji Y, Skime M, Paquola AC, Nelson T, Hall-Flavin D, Heard KJ, Fredlender C, Deng Y, Elkins J, Dani K, Le AT, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30903001; PMCID: PMC7409972.
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Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature. 2019 03; 567(7749):535-539. Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. PMID: 30867594; PMCID: PMC6557285.
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Microglia, complement and schizophrenia. Nat Neurosci. 2019 03; 22(3):333-334. Wang M, Zhang L, Gage FH. PMID: 30796420.
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Species-specific maturation profiles of human, chimpanzee and bonobo neural cells. Elife. 2019 02 07; 8. Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH. PMID: 30730291; PMCID: PMC6366899.
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Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders. Antioxid Redox Signal. 2019 08 01; 31(4):275-317. Kim Y, Vadodaria KC, Lenkei Z, Kato T, Gage FH, Marchetto MC, Santos R. PMID: 30585734; PMCID: PMC6602118.
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Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 06; 24(6):795-807. Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. PMID: 30700803.
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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2019 Jan 16; 101(2):349. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30653936; PMCID: PMC6377243.
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BrainImageR: spatiotemporal gene set analysis referencing the human brain. Bioinformatics. 2019 01 15; 35(2):343-345. Linker SB, Hsu JY, Pfaff A, Amatya D, Ko SM, Voter S, Wong Q, Gage FH. PMID: 30010719; PMCID: PMC6657270.
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Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping. Front Neuroanat. 2018; 12:115. Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 30666191; PMCID: PMC6330333.
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Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nat Neurosci. 2019 02; 22(2):243-255. Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH. PMID: 30617258; PMCID: PMC6402576.
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Limits to human neurogenesis-really? Mol Psychiatry. 2020 10; 25(10):2207-2209. Lucassen PJ, Toni N, Kempermann G, Frisen J, Gage FH, Swaab DF. PMID: 30617274; PMCID: PMC7515796.
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Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology. 2019 02; 44(3):620-628. McCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D'Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. PMID: 30487653; PMCID: PMC6333516.
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Long-Term Labeling of Hippocampal Neural Stem Cells by a Lentiviral Vector. Front Mol Neurosci. 2018; 11:415. Suh H, Zhou QG, Fernandez-Carasa I, Clemenson GD, Pons-Espinal M, Ro EJ, Marti M, Raya A, Gage FH, Consiglio A. PMID: 30498432; PMCID: PMC6249367.
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Adult Hippocampal Neurogenesis: A Coming-of-Age Story. J Neurosci. 2018 12 05; 38(49):10401-10410. Kuhn HG, Toda T, Gage FH. PMID: 30381404; PMCID: PMC6284110.
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Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases. Annu Rev Genet. 2018 11 23; 52:271-293. Mertens J, Reid D, Lau S, Kim Y, Gage FH. PMID: 30208291; PMCID: PMC6415910.
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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. PMID: 30190379; PMCID: PMC6149542.
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Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 2018 09 05; 99(5):925-940.e7. Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, Corjuc BT, DeVos SL, Gonzalez JA, Chew J, Vidensky S, Gage FH, Mertens J, Troncoso J, Mandelkow E, Salvatella X, Lim RYH, Petrucelli L, Wegmann S, Rothstein JD, Hyman BT. PMID: 30189209; PMCID: PMC6240334.
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Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. Front Mol Neurosci. 2018; 11:261. van den Hurk M, Erwin JA, Yeo GW, Gage FH, Bardy C. PMID: 30147644; PMCID: PMC6096303.
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A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons. Nat Commun. 2018 08 06; 9(1):3084. Jaeger BN, Linker SB, Parylak SL, Barron JJ, Gallina IS, Saavedra CD, Fitzpatrick C, Lim CK, Schafer ST, Lacar B, Jessberger S, Gage FH. PMID: 30082781; PMCID: PMC6079101.
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Erratum: An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 08 06; 36(8):772. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 30080830.
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Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2018 Jul 05; 23(1):123-131.e6. Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. PMID: 29979986.
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Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2018 Jul; 21(7):1016. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 29703932.
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Author Correction: CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 Jun; 21(6):894. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29545585.
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Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. Cell Rep. 2018 05 29; 23(9):2550-2558. Kim Y, Zheng X, Ansari Z, Bunnell MC, Herdy JR, Traxler L, Lee H, Paquola ACM, Blithikioti C, Ku M, Schlachetzki JCM, Winkler J, Edenhofer F, Glass CK, Paucar AA, Jaeger BN, Pham S, Boyer L, Campbell BC, Hunter T, Mertens J, Gage FH. PMID: 29847787; PMCID: PMC6478017.
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Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med. 2018 05 09; 10(440). Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M. PMID: 29743351.
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Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro. Cell Stem Cell. 2018 05 03; 22(5):684-697.e9. Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH. PMID: 29727680; PMCID: PMC6345574.
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Prediction of response to drug therapy in psychiatric disorders. Open Biol. 2018 05; 8(5). Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. PMID: 29794033; PMCID: PMC5990649.
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The role of adult hippocampal neurogenesis in brain health and disease. Mol Psychiatry. 2019 01; 24(1):67-87. Toda T, Parylak SL, Linker SB, Gage FH. PMID: 29679070; PMCID: PMC6195869.
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Human Adult Neurogenesis: Evidence and Remaining Questions. Cell Stem Cell. 2018 Jul 05; 23(1):25-30. Kempermann G, Gage FH, Aigner L, Song H, Curtis MA, Thuret S, Kuhn HG, Jessberger S, Frankland PW, Cameron HA, Gould E, Hen R, Abrous DN, Toni N, Schinder AF, Zhao X, Lucassen PJ, Frisén J. PMID: 29681514; PMCID: PMC6035081.
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An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018 06; 36(5):432-441. Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. PMID: 29658944; PMCID: PMC6331203.
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Early life experience drives structural variation of neural genomes in mice. Science. 2018 03 23; 359(6382):1395-1399. Bedrosian TA, Quayle C, Novaresi N, Gage FH. PMID: 29567711.
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CRISPR interference-based specific and efficient gene inactivation in the brain. Nat Neurosci. 2018 03; 21(3):447-454. Zheng Y, Shen W, Zhang J, Yang B, Liu YN, Qi H, Yu X, Lu SY, Chen Y, Xu YZ, Li Y, Gage FH, Mi S, Yao J. PMID: 29403034.
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Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward. Genome Med. 2018 01 04; 10(1):1. Vadodaria KC, Amatya DN, Marchetto MC, Gage FH. PMID: 29301565; PMCID: PMC5755287.
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MicroRNAs in Post-traumatic Stress Disorder. Curr Top Behav Neurosci. 2018; 38:23-46. Snijders C, de Nijs L, Baker DG, Hauger RL, van den Hove D, Kenis G, Nievergelt CM, Boks MP, Vermetten E, Gage FH, Rutten BPF. PMID: 29063484.
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Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res. 2018 Sep; 373(3):693-709. Toda T, Gage FH. PMID: 29185071.
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Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation. Mol Aspects Med. 2018 06; 61:50-62. Jaeger BN, Parylak SL, Gage FH. PMID: 29117513.
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Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2017 Sep 28; 20(10):1427. Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 28949329.
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An in vitro model of lissencephaly: expanding the role of DCX during neurogenesis. Mol Psychiatry. 2018 07; 23(7):1674-1684. Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, Dahl N, Gage FH, Falk A. PMID: 28924182.
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Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells. Cell Stem Cell. 2017 Nov 02; 21(5):618-634.e7. Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH. PMID: 28919367.
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Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2017 09 05; 20(10):2525. Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. PMID: 28877483; PMCID: PMC5599129.
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Serotonin in psychiatry: in vitro disease modeling using patient-derived neurons. Cell Tissue Res. 2018 01; 371(1):161-170. Vadodaria KC, Stern S, Marchetto MC, Gage FH. PMID: 28812143.
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Examining non-LTR retrotransposons in the context of the evolving primate brain. BMC Biol. 2017 08 11; 15(1):68. Linker SB, Marchetto MC, Narvaiza I, Denli AM, Gage FH. PMID: 28800766; PMCID: PMC5554003.
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Intact piRNA pathway prevents L1 mobilization in male meiosis. Proc Natl Acad Sci U S A. 2017 07 11; 114(28):E5635-E5644. Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W. PMID: 28630288; PMCID: PMC5514719.
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Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 06 06; 8(6):1757-1769. Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage FH. PMID: 28591655; PMCID: PMC5470172.
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An environment-dependent transcriptional network specifies human microglia identity. Science. 2017 06 23; 356(6344). Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK. PMID: 28546318; PMCID: PMC5858585.
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Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nat Commun. 2017 05 02; 8:15157. Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. PMID: 28462912; PMCID: PMC5418582.
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Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science. 2017 04 28; 356(6336). McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, Mills RE, Paquola ACM, Rodin RE, Rosenbluh C, Sestan N, Sherman MA, Shin JH, Song S, Straub RE, Thorpe J, Weinberger DR, Urban AE, Zhou B, Gage FH, Lehner T, Senthil G, Walsh CA, Chess A, Courchesne E, Gleeson JG, Kidd JM, Park PJ, Pevsner J, Vaccarino FM, Brain Somatic Mosaicism Network. PMID: 28450582; PMCID: PMC5558435.
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Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2017 04 15; 31(8):845. Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 28512238; PMCID: PMC5435895.
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Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2017 03 17; 8:15047. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 28303884; PMCID: PMC5357833.
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Conserved expression of transposon-derived non-coding transcripts in primate stem cells. BMC Genomics. 2017 02 28; 18(1):214. Ramsay L, Marchetto MC, Caron M, Chen SH, Busche S, Kwan T, Pastinen T, Gage FH, Bourque G. PMID: 28245871; PMCID: PMC5331655.
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Neurons derived from patients with bipolar disorder divide into intrinsically different sub-populations of neurons, predicting the patients' responsiveness to lithium. Mol Psychiatry. 2018 06; 23(6):1453-1465. Stern S, Santos R, Marchetto MC, Mendes APD, Rouleau GA, Biesmans S, Wang QW, Yao J, Charnay P, Bang AG, Alda M, Gage FH. PMID: 28242870; PMCID: PMC5573640.
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Molecular Mechanisms of Bipolar Disorder: Progress Made and Future Challenges. Front Cell Neurosci. 2017; 11:30. Kim Y, Santos R, Gage FH, Marchetto MC. PMID: 28261061; PMCID: PMC5306135.
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Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology. J Neurosci. 2017 02 15; 37(7):1675-1684. Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. PMID: 28039370; PMCID: PMC5320602.
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Insights into the role of somatic mosaicism in the brain. Curr Opin Syst Biol. 2017 Feb; 1:90-94. Paquola ACM, Erwin JA, Gage FH. PMID: 29226270; PMCID: PMC5718369.
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A role for miR-19 in the migration of adult-born neurons and schizophrenia. Neurogenesis (Austin). 2016; 3(1):e1251873. Han J, Gage FH. PMID: 28405585; PMCID: PMC5384614.
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Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. Cell. 2016 Nov 03; 167(4):897-914. Gonçalves JT, Schafer ST, Gage FH. PMID: 27814520.
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Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. Mol Psychiatry. 2016 11; 21(11):1573-1588. Bardy C, van den Hurk M, Kakaradov B, Erwin JA, Jaeger BN, Hernandez RV, Eames T, Paucar AA, Gorris M, Marchand C, Jappelli R, Barron J, Bryant AK, Kellogg M, Lasken RS, Rutten BP, Steinbusch HW, Yeo GW, Gage FH. PMID: 27698428; PMCID: PMC5071135.
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Generating human serotonergic neurons in vitro: Methodological advances. Bioessays. 2016 11; 38(11):1123-1129. Vadodaria KC, Marchetto MC, Mertens J, Gage FH. PMID: 27716980.
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L1-associated genomic regions are deleted in somatic cells of the healthy human brain. Nat Neurosci. 2016 12; 19(12):1583-1591. Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH. PMID: 27618310; PMCID: PMC5127747.
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Dopaminergic inputs in the dentate gyrus direct the choice of memory encoding. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5501-10. Du H, Deng W, Aimone JB, Ge M, Parylak S, Walch K, Zhang W, Cook J, Song H, Wang L, Gage FH, Mu Y. PMID: 27573822; PMCID: PMC5027420.
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A human neurodevelopmental model for Williams syndrome. Nature. 2016 08 18; 536(7616):338-43. Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR. PMID: 27509850; PMCID: PMC4995142.
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Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature. 2016 08 11; 536(7615):205-9. Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Camponeschi F, Ciofi-Baffoni S, Stessman HA, Marchetto MC, Denman L, Harshman L, Baker C, Raja A, Penewit K, Janke N, Tang WJ, Ventura M, Banci L, Antonacci F, Akey JM, Amemiya CT, Gage FH, Reymond A, Eichler EE. PMID: 27487209; PMCID: PMC4988886.
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Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency. Epigenomics. 2016 08; 8(8):1131-49. van den Hurk M, Kenis G, Bardy C, van den Hove DL, Gage FH, Steinbusch HW, Rutten BP. PMID: 27419933; PMCID: PMC5514980.
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Diverse Representations of Olfactory Information in Centrifugal Feedback Projections. J Neurosci. 2016 07 13; 36(28):7535-45. Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ. PMID: 27413162; PMCID: PMC4945671.
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Functional Implications of miR-19 in the Migration of Newborn Neurons in the Adult Brain. Neuron. 2016 07 06; 91(1):79-89. Han J, Kim HJ, Schafer ST, Paquola A, Clemenson GD, Toda T, Oh J, Pankonin AR, Lee BS, Johnston ST, Sarkar A, Denli AM, Gage FH. PMID: 27387650.
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Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. Trends Mol Med. 2016 08; 22(8):633-634. Gage FH, Guarente LP, Wagers AJ. PMID: 27396512.
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Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017 06; 22(6):820-835. Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR. PMID: 27378147; PMCID: PMC5215991.
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Corrigendum: Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 06 14; 7:12020. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJ, Parylak SL, Paquola AC, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 27295945; PMCID: PMC4911670.
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Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation. Elife. 2016 06 10; 5. Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L, Ma L, Hamm M, Gage FH, Hunter T. PMID: 27282387; PMCID: PMC4963198.
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Environment-driven somatic mosaicism in brain disorders. Genome Med. 2016 05 23; 8(1):58. Bedrosian TA, Linker S, Gage FH. PMID: 27215330; PMCID: PMC4877941.
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Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. Nat Rev Neurosci. 2016 07; 17(7):424-37. Mertens J, Marchetto MC, Bardy C, Gage FH. PMID: 27194476; PMCID: PMC6276815.
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What is memory? The present state of the engram. BMC Biol. 2016 05 19; 14:40. Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C. PMID: 27197636; PMCID: PMC4874022.
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Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016 05 15; 30(10):1155-71. Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW. PMID: 27198230; PMCID: PMC4888837.
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The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry. 2016 May 05; 16:129. Oedegaard KJ, Alda M, Anand A, Andreassen OA, Balaraman Y, Berrettini WH, Bhattacharjee A, Brennand KJ, Burdick KE, Calabrese JR, Calkin CV, Claasen A, Coryell WH, Craig D, DeModena A, Frye M, Gage FH, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband SG, McCarthy MJ, McInnis MG, Maihofer AX, Mertens J, Morken G, Nievergelt CM, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling PD, Szelinger S, Tarwater B, Yao J, Zandi PP, Kelsoe JR. PMID: 27150464; PMCID: PMC4857276.
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In vivo imaging of dendritic pruning in dentate granule cells. Nat Neurosci. 2016 06; 19(6):788-91. Gonçalves JT, Bloyd CW, Shtrahman M, Johnston ST, Schafer ST, Parylak SL, Tran T, Chang T, Gage FH. PMID: 27135217; PMCID: PMC4941946.
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GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient induced pluripotent stem cell model. Ann Neurol. 2016 May; 79(5):826-840. Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B. PMID: 26971897; PMCID: PMC5084783.
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Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Rep. 2016 05 03; 15(5):1024-1036. Topol A, Zhu S, Hartley BJ, English J, Hauberg ME, Tran N, Rittenhouse CA, Simone A, Ruderfer DM, Johnson J, Readhead B, Hadas Y, Gochman PA, Wang YC, Shah H, Cagney G, Rapoport J, Gage FH, Dudley JT, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand KJ. PMID: 27117414; PMCID: PMC4856588.
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Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat Commun. 2016 04 19; 7:11022. Lacar B, Linker SB, Jaeger BN, Krishnaswami SR, Barron JJ, Kelder MJE, Parylak SL, Paquola ACM, Venepally P, Novotny M, O'Connor C, Fitzpatrick C, Erwin JA, Hsu JY, Husband D, McConnell MJ, Lasken R, Gage FH. PMID: 27090946; PMCID: PMC4838832.
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The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. J Neurosci. 2016 Apr 13; 36(15):4259-75. Harrison BJ, Venkat G, Lamb JL, Hutson TH, Drury C, Rau KK, Bunge MB, Mendell LM, Gage FH, Johnson RD, Hill CE, Rouchka EC, Moon LD, Petruska JC. PMID: 27076424; PMCID: PMC4829650.
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α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathol. 2016 07; 132(1):59-75. Ettle B, Kerman BE, Valera E, Gillmann C, Schlachetzki JC, Reiprich S, Büttner C, Ekici AB, Reis A, Wegner M, Bäuerle T, Riemenschneider MJ, Masliah E, Gage FH, Winkler J. PMID: 27059609; PMCID: PMC4912450.
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2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size. Cell Stem Cell. 2016 Apr 07; 18(4):467-80. Otani T, Marchetto MC, Gage FH, Simons BD, Livesey FJ. PMID: 27049876; PMCID: PMC4826446.
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Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration. Elife. 2016 03 23; 5. Zheng X, Boyer L, Jin M, Kim Y, Fan W, Bardy C, Berggren T, Evans RM, Gage FH, Hunter T. PMID: 27008180; PMCID: PMC4846388.
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Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons. Nat Protoc. 2016 Mar; 11(3):499-524. Krishnaswami SR, Grindberg RV, Novotny M, Venepally P, Lacar B, Bhutani K, Linker SB, Pham S, Erwin JA, Miller JA, Hodge R, McCarthy JK, Kelder M, McCorrison J, Aevermann BD, Fuertes FD, Scheuermann RH, Lee J, Lein ES, Schork N, McConnell MJ, Gage FH, Lasken RS. PMID: 26890679; PMCID: PMC4941947.
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A Mechanism for Somatic Brain Mosaicism. Cell. 2016 Feb 11; 164(4):593-5. Weissman IL, Gage FH. PMID: 26871622.
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Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. PMID: 26829621; PMCID: PMC4731185.
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KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):751-6. Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G. PMID: 26733678; PMCID: PMC4725523.
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The different moods of human serotonergic neurons. Mol Psychiatry. 2016 Jan; 21(1):3. Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. PMID: 26678308.
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Synaptic activity: An emerging player in schizophrenia. Brain Res. 2017 02 01; 1656:68-75. Sarkar A, Marchetto MC, Gage FH. PMID: 26723567.
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Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016 Jan; 139(Pt 1):259-75. Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Wood TC, Bernanos M, Cash D, Williams SC, Gage FH, Moon LD. PMID: 26614754; PMCID: PMC4785394.
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Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2016 Feb 11; 530(7589):242. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Oedegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26605530.
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Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports. 2015 Dec 08; 5(6):933-945. Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. PMID: 26610635; PMCID: PMC4881284.
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Paradox of pattern separation and adult neurogenesis: A dual role for new neurons balancing memory resolution and robustness. Neurobiol Learn Mem. 2016 Mar; 129:60-8. Johnston ST, Shtrahman M, Parylak S, Gonçalves JT, Gage FH. PMID: 26549627; PMCID: PMC4792723.
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REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II. J Neurosci. 2015 Nov 04; 35(44):14872-84. Kim HJ, Denli AM, Wright R, Baul TD, Clemenson GD, Morcos AS, Zhao C, Schafer ST, Gage FH, Kagalwala MN. PMID: 26538656; PMCID: PMC4635134.
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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature. 2015 Nov 05; 527(7576):95-9. Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames T, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Ødegaard KJ, McCarthy MJ, Zandi PP, Alda M, Alba M, Nievergelt CM, Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J. PMID: 26524527; PMCID: PMC4742055.
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Generation of functional human serotonergic neurons from fibroblasts. Mol Psychiatry. 2016 Jan; 21(1):49-61. Vadodaria KC, Mertens J, Paquola A, Bardy C, Li X, Jappelli R, Fung L, Marchetto MC, Hamm M, Gorris M, Koch P, Gage FH. PMID: 26503761.
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Primate-specific ORF0 contributes to retrotransposon-mediated diversity. Cell. 2015 Oct 22; 163(3):583-93. Denli AM, Narvaiza I, Kerman BE, Pena M, Benner C, Marchetto MC, Diedrich JK, Aslanian A, Ma J, Moresco JJ, Moore L, Hunter T, Saghatelian A, Gage FH. PMID: 26496605.
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Distinct roles of NMDA receptors at different stages of granule cell development in the adult brain. Elife. 2015 Oct 16; 4:e07871. Mu Y, Zhao C, Toni N, Yao J, Gage FH. PMID: 26473971; PMCID: PMC4608052.
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Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Dec 03; 17(6):705-718. Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH. PMID: 26456686; PMCID: PMC5929130.
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Purification and Injection of Retroviral Vectors. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):925-31. Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430255.
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Imaging Newborn Granule Cells in Fixed Sections. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):932-3. Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430256.
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Analysis of Spine Motility of Newborn Granule Cells in Acute Brain Slices. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):934-6. Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430257.
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Preparation and Use of Retroviral Vectors for Labeling, Imaging, and Genetically Manipulating Cells. Cold Spring Harb Protoc. 2015 Oct 01; 2015(10):883-8. Tashiro A, Zhao C, Suh H, Gage FH. PMID: 26430260.
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Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest. Cell. 2015 Sep 24; 163(1):68-83. Prescott SL, Srinivasan R, Marchetto MC, Grishina I, Narvaiza I, Selleri L, Gage FH, Swigut T, Wysocka J. PMID: 26365491; PMCID: PMC4848043.
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Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015 Sep; 18(9):1226-9. Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. PMID: 26308983; PMCID: PMC4552077.
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Neurogenesis in the Adult Hippocampus. Cold Spring Harb Perspect Biol. 2015 Sep 01; 7(9):a018812. Kempermann G, Song H, Gage FH. PMID: 26330519; PMCID: PMC4563705.
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Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 01; 12(9):1385-90. Firth AL, Menon T, Parker GS, Qualls SJ, Lewis BM, Ke E, Dargitz CT, Wright R, Khanna A, Gage FH, Verma IM. PMID: 26299960; PMCID: PMC4559351.
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MIR137: big impacts from small changes. Nat Neurosci. 2015 Jul; 18(7):931-3. Han J, Sarkar A, Gage FH. PMID: 26108719.
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Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2015 Jul 01; 523(10):1588. Zhao C, Jou J, Wolff LJ, Sun H, Gage FH. PMID: 26109421.
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In vitro myelin formation using embryonic stem cells. Development. 2015 Jun 15; 142(12):2213-25. Kerman BE, Kim HJ, Padmanabhan K, Mei A, Georges S, Joens MS, Fitzpatrick JA, Jappelli R, Chandross KJ, August P, Gage FH. PMID: 26015546; PMCID: PMC4483765.
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Alzheimer's disease: distinct stages in neurogenic decline? Biol Psychiatry. 2015 Apr 15; 77(8):680-2. Adamowicz DH, Mertens J, Gage FH. PMID: 25835286.
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Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2725-34. Bardy C, van den Hurk M, Eames T, Marchand C, Hernandez RV, Kellogg M, Gorris M, Galet B, Palomares V, Brown J, Bang AG, Mertens J, Böhnke L, Boyer L, Simon S, Gage FH. PMID: 25870293; PMCID: PMC4443325.
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Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism. Cell Metab. 2015 Apr 07; 21(4):628-36. Pei L, Mu Y, Leblanc M, Alaynick W, Barish GD, Pankratz M, Tseng TW, Kaufman S, Liddle C, Yu RT, Downes M, Pfaff SL, Auwerx J, Gage FH, Evans RM. PMID: 25863252; PMCID: PMC4393848.
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SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15):E1936-45. Amador-Arjona A, Cimadamore F, Huang CT, Wright R, Lewis S, Gage FH, Terskikh AV. PMID: 25825708; PMCID: PMC4403144.
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The Wnt adaptor protein ATP6AP2 regulates multiple stages of adult hippocampal neurogenesis. J Neurosci. 2015 Mar 25; 35(12):4983-98. Schafer ST, Han J, Pena M, von Bohlen Und Halbach O, Peters J, Gage FH. PMID: 25810528; PMCID: PMC4389597.
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The effect of immature adult-born dentate granule cells on hyponeophagial behavior is related to their roles in learning and memory. Front Syst Neurosci. 2015; 9:34. Deng W, Gage FH. PMID: 25798094; PMCID: PMC4351587.
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Improving and accelerating drug development for nervous system disorders. Neuron. 2014 Nov 05; 84(3):546-53. Pankevich DE, Altevogt BM, Dunlop J, Gage FH, Hyman SE. PMID: 25442933; PMCID: PMC4254615.
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Enrichment rescues contextual discrimination deficit associated with immediate shock. Hippocampus. 2015 Mar; 25(3):385-92. Clemenson GD, Lee SW, Deng W, Barrera VR, Iwamoto KS, Fanselow MS, Gage FH. PMID: 25330953; PMCID: PMC4398310.
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Regulation and function of adult neurogenesis: from genes to cognition. Physiol Rev. 2014 Oct; 94(4):991-1026. Aimone JB, Li Y, Lee SW, Clemenson GD, Deng W, Gage FH. PMID: 25287858; PMCID: PMC4280160.
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Human iPSC neurons display activity-dependent neurotransmitter secretion: aberrant catecholamine levels in schizophrenia neurons. Stem Cell Reports. 2014 Oct 14; 3(4):531-8. Hook V, Brennand KJ, Kim Y, Toneff T, Funkelstein L, Lee KC, Ziegler M, Gage FH. PMID: 25358781; PMCID: PMC4223699.
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Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Mol Psychiatry. 2014 Nov; 19(11):1235-42. Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. PMID: 25113378; PMCID: PMC4217144.
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Adult neurogenesis: bridging the gap between mice and humans. Trends Cell Biol. 2014 Oct; 24(10):558-63. Jessberger S, Gage FH. PMID: 25124338.
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QnAs with Fred Gage. Proc Natl Acad Sci U S A. 2014 Sep 09; 111(36):12958-9. Gage F, Nair P. PMID: 25049423; PMCID: PMC4246929.
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Mobile DNA elements in the generation of diversity and complexity in the brain. Nat Rev Neurosci. 2014 Aug; 15(8):497-506. Erwin JA, Marchetto MC, Gage FH. PMID: 25005482; PMCID: PMC4443810.
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A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 2014 Jul 02; 83(1):69-86. Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. PMID: 24991955; PMCID: PMC4277209.
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How to make a hippocampal dentate gyrus granule neuron. Development. 2014 Jun; 141(12):2366-75. Yu DX, Marchetto MC, Gage FH. PMID: 24917496.
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Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories. Hippocampus. 2014 Aug; 24(8):905-11. Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ. PMID: 24825389; PMCID: PMC4312906.
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Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease. Hum Mol Genet. 2014 Sep 15; 23(R1):R27-34. Winner B, Marchetto MC, Winkler J, Gage FH. PMID: 24821704.
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Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus. Brain Struct Funct. 2015 Jul; 220(4):2027-42. Krzisch M, Temprana SG, Mongiat LA, Armida J, Schmutz V, Virtanen MA, Kocher-Braissant J, Kraftsik R, Vutskits L, Conzelmann KK, Bergami M, Gage FH, Schinder AF, Toni N. PMID: 24748560; PMCID: PMC4481333.
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Spine morphogenesis in newborn granule cells is differentially regulated in the outer and middle molecular layers. J Comp Neurol. 2014 Aug 15; 522(12):2756-66. Zhao C, Jou J, Wolff LJ, Sun H, Gage FH. PMID: 24610721; PMCID: PMC4065223.
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Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 2014 May 07; 82(3):560-72. Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. PMID: 24726381; PMCID: PMC4051437.
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Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Mol Psychiatry. 2015 Mar; 20(3):361-8. Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao SH, Mrksich M, Rakic P, Fang G, Zhang B, Yates JR, Gage FH. PMID: 24686136; PMCID: PMC4182344.
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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May; 137(Pt 5):1496-513. Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, Winner B, Masliah E. PMID: 24662516; PMCID: PMC3999721.
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Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. Firth AL, Dargitz CT, Qualls SJ, Menon T, Wright R, Singer O, Gage FH, Khanna A, Verma IM. PMID: 24706852; PMCID: PMC4035971.
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Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):E1240-8. Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM. PMID: 24639535; PMCID: PMC3977248.
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Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nat Neurosci. 2014 Apr; 17(4):513-21. Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK. PMID: 24584051; PMCID: PMC4113004.
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Enhancing induced pluripotent stem cell models of schizophrenia. JAMA Psychiatry. 2014 Mar; 71(3):334-5. Wright R, Réthelyi JM, Gage FH. PMID: 24382673.
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SnapShot: adult hippocampal neurogenesis. Cell. 2014 Feb 27; 156(5):1114-1114.e1. Vadodaria KC, Gage FH. PMID: 24581504.
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Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem Cell Reports. 2014 Mar 11; 2(3):295-310. Yu DX, Di Giorgio FP, Yao J, Marchetto MC, Brennand K, Wright R, Mei A, McHenry L, Lisuk D, Grasmick JM, Silberman P, Silberman G, Jappelli R, Gage FH. PMID: 24672753; PMCID: PMC3964286.
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Increasing the resolution of the adult neurogenesis picture. F1000Prime Rep. 2014; 6:8. Lacar B, Parylak SL, Vadodaria KC, Sarkar A, Gage FH. PMID: 24592320; PMCID: PMC3914506.
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Mother's milk programs offspring's cognition. Nat Neurosci. 2014 Jan; 17(1):8-9. Parylak SL, Deng W, Gage FH. PMID: 24369371.
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Your brain under the microscope: the promise of stem cells. Cerebrum. 2014 Jan; 2014:1. Marchetto MC, Gage FH. PMID: 25009691; PMCID: PMC4087191.
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Temporally selective contextual encoding in the dentate gyrus of the hippocampus. Nat Commun. 2014; 5:3181. Rangel LM, Alexander AS, Aimone JB, Wiles J, Gage FH, Chiba AA, Quinn LK. PMID: 24518986; PMCID: PMC3929785.
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Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons. Hum Mol Genet. 2014 May 15; 23(10):2527-41. Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer L, Marchetto MC, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. PMID: 24381312; PMCID: PMC3990156.
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RNA-sequencing from single nuclei. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19802-7. Grindberg RV, Yee-Greenbaum JL, McConnell MJ, Novotny M, O'Shaughnessy AL, Lambert GM, Araúzo-Bravo MJ, Lee J, Fishman M, Robbins GE, Lin X, Venepally P, Badger JH, Galbraith DW, Gage FH, Lasken RS. PMID: 24248345; PMCID: PMC3856806.
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The role of transposable elements in health and diseases of the central nervous system. J Neurosci. 2013 Nov 06; 33(45):17577-86. Reilly MT, Faulkner GJ, Dubnau J, Ponomarev I, Gage FH. PMID: 24198348; PMCID: PMC3818539.
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Mosaic copy number variation in human neurons. Science. 2013 Nov 01; 342(6158):632-7. McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. PMID: 24179226; PMCID: PMC3975283.
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Neural stem cells: generating and regenerating the brain. Neuron. 2013 Oct 30; 80(3):588-601. Gage FH, Temple S. PMID: 24183012.
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BDNF in the dentate gyrus is required for consolidation of "pattern-separated" memories. Cell Rep. 2013 Nov 14; 5(3):759-68. Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ. PMID: 24209752; PMCID: PMC3898274.
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Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov; 140(22):4633-44. Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Šestan N, Gage FH, Lein ES. PMID: 24154525; PMCID: PMC3817946.
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Differential L1 regulation in pluripotent stem cells of humans and apes. Nature. 2013 Nov 28; 503(7477):525-529. Marchetto MCN, Narvaiza I, Denli AM, Benner C, Lazzarini TA, Nathanson JL, Paquola ACM, Desai KN, Herai RH, Weitzman MD, Yeo GW, Muotri AR, Gage FH. PMID: 24153179; PMCID: PMC4064720.
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A regenerative approach to the treatment of multiple sclerosis. Nature. 2013 Oct 17; 502(7471):327-332. Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. PMID: 24107995; PMCID: PMC4431622.
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Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells. Biol Psychiatry. 2014 Jun 15; 75(12):929-35. Hrvoj-Mihic B, Marchetto MC, Gage FH, Semendeferi K, Muotri AR. PMID: 24041506.
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P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury. PLoS One. 2013; 8(7):e69286. Sung TC, Chen Z, Thuret S, Vilar M, Gage FH, Riek R, Lee KF. PMID: 23935974; PMCID: PMC3720591.
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Therapeutic translation of iPSCs for treating neurological disease. Cell Stem Cell. 2013 Jun 06; 12(6):678-88. Yu DX, Marchetto MC, Gage FH. PMID: 23746977.
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Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Sci Transl Med. 2013 Jun 05; 5(188):188lr2. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. PMID: 23740898.
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FOXO4 is necessary for neural differentiation of human embryonic stem cells. Aging Cell. 2013 Jun; 12(3):518-22. Vilchez D, Boyer L, Lutz M, Merkwirth C, Morantte I, Tse C, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. PMID: 23551888; PMCID: PMC4864013.
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Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells. Stem Cell Res. 2013 Sep; 11(2):743-57. Tang X, Zhou L, Wagner AM, Marchetto MC, Muotri AR, Gage FH, Chen G. PMID: 23759711; PMCID: PMC3979966.
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A hypothesis for temporal coding of young and mature granule cells. Front Neurosci. 2013; 7:75. Rangel LM, Quinn LK, Chiba AA, Gage FH, Aimone JB. PMID: 23717259; PMCID: PMC3653099.
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Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9106-11. Li Y, Stam FJ, Aimone JB, Goulding M, Callaway EM, Gage FH. PMID: 23671081; PMCID: PMC3670356.
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Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120). Neurobiol Dis. 2013 Oct; 58:38-48. Herzog CD, Brown L, Kruegel BR, Wilson A, Tansey MG, Gage FH, Johnson EM, Bartus RT. PMID: 23631873.
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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med. 2013 Apr; 19(4):473-80. Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H. PMID: 23524343; PMCID: PMC3911880.
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Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice. Elife. 2013 Mar 20; 2:e00312. Deng W, Mayford M, Gage FH. PMID: 23538967; PMCID: PMC3602954.
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Dynamic association of NUP98 with the human genome. PLoS Genet. 2013; 9(2):e1003308. Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW. PMID: 23468646; PMCID: PMC3585015.
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Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013 Feb 27; 33(9):4066-75. Shimozaki K, Clemenson GD, Gage FH. PMID: 23447615; PMCID: PMC6619329.
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Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods. 2013 Jan; 10(1):77-83. Kurian L, Sancho-Martinez I, Nivet E, Aguirre A, Moon K, Pendaries C, Volle-Challier C, Bono F, Herbert JM, Pulecio J, Xia Y, Li M, Montserrat N, Ruiz S, Dubova I, Rodriguez C, Denli AM, Boscolo FS, Thiagarajan RD, Gage FH, Loring JF, Laurent LC, Izpisua Belmonte JC. PMID: 23202434; PMCID: PMC3531579.
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Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci. 2012 Nov 21; 32(47):16906-16. Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage FH. PMID: 23175842; PMCID: PMC4962062.
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Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol. 2012 Nov; 13(11):713-26. Bellin M, Marchetto MC, Gage FH, Mummery CL. PMID: 23034453.
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An exploratory study of combination buspirone and melatonin SR in major depressive disorder (MDD): a possible role for neurogenesis in drug discovery. J Psychiatr Res. 2012 Dec; 46(12):1553-63. Fava M, Targum SD, Nierenberg AA, Bleicher LS, Carter TA, Wedel PC, Hen R, Gage FH, Barlow C. PMID: 22998742.
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Increased proteasome activity in human embryonic stem cells is regulated by PSMD11. Nature. 2012 Sep 13; 489(7415):304-8. Vilchez D, Boyer L, Morantte I, Lutz M, Merkwirth C, Joyce D, Spencer B, Page L, Masliah E, Berggren WT, Gage FH, Dillin A. PMID: 22972301; PMCID: PMC5215918.
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Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med. 2012 Aug 01; 4(145):145ra104. Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MC, Gage FH, Yamanaka S, Inoue H. PMID: 22855461.
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Dopaminergic differentiation of human pluripotent cells. Curr Protoc Stem Cell Biol. 2012 Aug; Chapter 1:Unit1H.6. Boyer LF, Campbell B, Larkin S, Mu Y, Gage FH. PMID: 22872424.
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Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12556-61. Giorgetti A, Marchetto MC, Li M, Yu D, Fazzina R, Mu Y, Adamo A, Paramonov I, Cardoso JC, Monasterio MB, Bardy C, Cassiani-Ingoni R, Liu GH, Gage FH, Izpisua Belmonte JC. PMID: 22814375; PMCID: PMC3412010.
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Modeling brain disease in a dish: really? Cell Stem Cell. 2012 Jun 14; 10(6):642-645. Marchetto MC, Gage FH. PMID: 22704498.
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Electroconvulsive seizure promotes spine maturation in newborn dentate granule cells in adult rat. Dev Neurobiol. 2012 Jun; 72(6):937-42. Zhao C, Warner-Schmidt J, Duman RS, Gage FH. PMID: 21976455; PMCID: PMC3623264.
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Neural stem cells: mechanisms and modeling. Protein Cell. 2012 Apr; 3(4):251-61. Yao J, Mu Y, Gage FH. PMID: 22549585; PMCID: PMC4875476.
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Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry. 2012 Dec; 17(12):1239-53. Brennand KJ, Simone A, Tran N, Gage FH. PMID: 22472874; PMCID: PMC3465628.
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Local generation of glia is a major astrocyte source in postnatal cortex. Nature. 2012 Mar 28; 484(7394):376-80. Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. PMID: 22456708; PMCID: PMC3777276.
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Gene expression profiling of neural stem cells and their neuronal progeny reveals IGF2 as a regulator of adult hippocampal neurogenesis. J Neurosci. 2012 Mar 07; 32(10):3376-87. Bracko O, Singer T, Aigner S, Knobloch M, Winner B, Ray J, Clemenson GD, Suh H, Couillard-Despres S, Aigner L, Gage FH, Jessberger S. PMID: 22399759; PMCID: PMC3338187.
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What makes each brain unique. Sci Am. 2012 Mar; 306(3):26-31. Gage FH, Muotri AR. PMID: 22375319.
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Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4290-5. Li Y, Aimone JB, Xu X, Callaway EM, Gage FH. PMID: 22371596; PMCID: PMC3306704.
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Enhanced functional recovery in MRL/MpJ mice after spinal cord dorsal hemisection. PLoS One. 2012; 7(2):e30904. Thuret S, Thallmair M, Horky LL, Gage FH. PMID: 22348029; PMCID: PMC3278405.
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Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25; 482(7384):216-20. Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. PMID: 22278060; PMCID: PMC3338985.
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ISSCR: beginning the next chapter. Cell Stem Cell. 2012 Jan 06; 10(1):29-31. Gage FH. PMID: 22226353.
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The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis. Genes Dev. 2012 Jan 01; 26(1):6-10. Han J, Denli AM, Gage FH. PMID: 22215805; PMCID: PMC3258967.
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Monosynaptic inputs to new neurons in the dentate gyrus. Nat Commun. 2012; 3:1107. Vivar C, Potter MC, Choi J, Lee JY, Stringer TP, Callaway EM, Gage FH, Suh H, van Praag H. PMID: 23033083; PMCID: PMC4603575.
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Transplantation in the future. Prog Brain Res. 2012; 200:7-13. Gage FH. PMID: 23195412.
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Transplantation in the future. Prog Brain Res. 2012; 201:7-13. Gage FH. PMID: 23186707.
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Differential effects of brain-derived neurotrophic factor and neurotrophin-3 on hindlimb function in paraplegic rats. Eur J Neurosci. 2012 Jan; 35(2):221-32. Boyce VS, Park J, Gage FH, Mendell LM. PMID: 22211901; PMCID: PMC3509221.
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Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener. 2011 Dec 22; 6:85. Mu Y, Gage FH. PMID: 22192775; PMCID: PMC3261815.
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SRY-box-containing gene 2 regulation of nuclear receptor tailless (Tlx) transcription in adult neural stem cells. J Biol Chem. 2012 Feb 17; 287(8):5969-78. Shimozaki K, Zhang CL, Suh H, Denli AM, Evans RM, Gage FH. PMID: 22194602; PMCID: PMC3285364.
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Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20382-7. Coufal NG, Garcia-Perez JL, Peng GE, Marchetto MC, Muotri AR, Mu Y, Carson CT, Macia A, Moran JV, Gage FH. PMID: 22159035; PMCID: PMC3251057.
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Concise review: the promise of human induced pluripotent stem cell-based studies of schizophrenia. Stem Cells. 2011 Dec; 29(12):1915-22. Brennand KJ, Gage FH. PMID: 22009633; PMCID: PMC3381343.
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New neurons in an aged brain. Behav Brain Res. 2012 Feb 14; 227(2):497-507. Lee SW, Clemenson GD, Gage FH. PMID: 22024433; PMCID: PMC3264739.
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Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. EMBO Mol Med. 2011 Dec; 3(12):742-54. Kuwabara T, Kagalwala MN, Onuma Y, Ito Y, Warashina M, Terashima K, Sanosaka T, Nakashima K, Gage FH, Asashima M. PMID: 21984534; PMCID: PMC3377118.
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Modeling psychiatric disorders through reprogramming. Dis Model Mech. 2012 Jan; 5(1):26-32. Brennand KJ, Gage FH. PMID: 21954066; PMCID: PMC3255540.
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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature. 2011 Sep 07; 477(7363):179-84. Zhu Q, Pao GM, Huynh AM, Suh H, Tonnu N, Nederlof PM, Gage FH, Verma IM. PMID: 21901007; PMCID: PMC3240576.
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Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet. 2011 Oct 15; 20(R2):R109-15. Marchetto MC, Brennand KJ, Boyer LF, Gage FH. PMID: 21828073; PMCID: PMC4447776.
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Genetically encoding unnatural amino acids in neural stem cells and optically reporting voltage-sensitive domain changes in differentiated neurons. Stem Cells. 2011 Aug; 29(8):1231-40. Shen B, Xiang Z, Miller B, Louie G, Wang W, Noel JP, Gage FH, Wang L. PMID: 21681861; PMCID: PMC3209808.
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Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes. Mol Ther. 2011 Oct; 19(10):1905-12. Hester ME, Murtha MJ, Song S, Rao M, Miranda CJ, Meyer K, Tian J, Boulting G, Schaffer DV, Zhu MX, Pfaff SL, Gage FH, Kaspar BK. PMID: 21772256; PMCID: PMC3188742.
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Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64. Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. PMID: 21544903; PMCID: PMC3254148.
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Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron. 2011 May 26; 70(4):589-96. Aimone JB, Deng W, Gage FH. PMID: 21609818; PMCID: PMC3240575.
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Modelling schizophrenia using human induced pluripotent stem cells. Nature. 2011 May 12; 473(7346):221-5. Brennand KJ, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage FH. PMID: 21490598; PMCID: PMC3392969.
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Dopaminergic modulation of cortical inputs during maturation of adult-born dentate granule cells. J Neurosci. 2011 Mar 16; 31(11):4113-23. Mu Y, Zhao C, Gage FH. PMID: 21411652; PMCID: PMC3073019.
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Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells. PLoS One. 2011 Mar 02; 6(3):e17540. Yuan SH, Martin J, Elia J, Flippin J, Paramban RI, Hefferan MP, Vidal JG, Mu Y, Killian RL, Israel MA, Emre N, Marsala S, Marsala M, Gage FH, Goldstein LS, Carson CT. PMID: 21407814; PMCID: PMC3047583.
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Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1160-9. Aimone JB, Gage FH. PMID: 21395860.
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Neurodegenerative disease and adult neurogenesis. Eur J Neurosci. 2011 Mar; 33(6):1139-51. Winner B, Kohl Z, Gage FH. PMID: 21395858.
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In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4194-9. Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. PMID: 21325059; PMCID: PMC3053976.
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Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3005-10. Kim JE, O'Sullivan ML, Sanchez CA, Hwang M, Israel MA, Brennand K, Deerinck TJ, Goldstein LS, Gage FH, Ellisman MH, Ghosh A. PMID: 21278334; PMCID: PMC3041068.
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Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis. 2011 Mar; 41(3):706-16. Winner B, Melrose HL, Zhao C, Hinkle KM, Yue M, Kent C, Braithwaite AT, Ogholikhan S, Aigner R, Winkler J, Farrer MJ, Gage FH. PMID: 21168496; PMCID: PMC3059106.
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High-efficient generation of induced pluripotent stem cells from human astrocytes. PLoS One. 2010 Dec 09; 5(12):e15526. Ruiz S, Brennand K, Panopoulos AD, Herrerías A, Gage FH, Izpisua-Belmonte JC. PMID: 21170306; PMCID: PMC3000364.
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L1 retrotransposition in neurons is modulated by MeCP2. Nature. 2010 Nov 18; 468(7322):443-6. Muotri AR, Marchetto MC, Coufal NG, Oefner R, Yeo G, Nakashima K, Gage FH. PMID: 21085180; PMCID: PMC3059197.
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PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 2011 Jan; 227(1):210-7. Meng X, Arocena M, Penninger J, Gage FH, Zhao M, Song B. PMID: 21092738; PMCID: PMC3821524.
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A distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis. J Comp Neurol. 2010 Nov 15; 518(22):4479-90. Mathews EA, Morgenstern NA, Piatti VC, Zhao C, Jessberger S, Schinder AF, Gage FH. PMID: 20886617; PMCID: PMC2997649.
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A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell. 2010 Nov 12; 143(4):527-39. Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, Chen G, Gage FH, Muotri AR. PMID: 21074045; PMCID: PMC3003590.
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Epigenetic choreographers of neurogenesis in the adult mammalian brain. Nat Neurosci. 2010 Nov; 13(11):1338-44. Ma DK, Marchetto MC, Guo JU, Ming GL, Gage FH, Song H. PMID: 20975758; PMCID: PMC3324277.
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Put them out to pasture? What are old granule cells good for, anyway...? Hippocampus. 2010 Oct; 20(10):1124-5. Aimone JB, Deng W, Gage FH. PMID: 20848611.
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Intramuscular AAV delivery of NT-3 alters synaptic transmission to motoneurons in adult rats. Eur J Neurosci. 2010 Sep; 32(6):997-1005. Petruska JC, Kitay B, Boyce VS, Kaspar BK, Pearse DD, Gage FH, Mendell LM. PMID: 20849530; PMCID: PMC2943849.
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Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol. 2010 Oct; 12(10):993-8. Liu D, Ou L, Clemenson GD, Chao C, Lutske ME, Zambetti GP, Gage FH, Xu Y. PMID: 20818388; PMCID: PMC3025300.
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Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14863-8. Valdez G, Tapia JC, Kang H, Clemenson GD, Gage FH, Lichtman JW, Sanes JR. PMID: 20679195; PMCID: PMC2930485.
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Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus. Cell Stem Cell. 2010 Jul 02; 7(1):78-89. Mira H, Andreu Z, Suh H, Lie DC, Jessberger S, Consiglio A, San Emeterio J, Hortigüela R, Marqués-Torrejón MA, Nakashima K, Colak D, Götz M, Fariñas I, Gage FH. PMID: 20621052.
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Signaling in adult neurogenesis. Curr Opin Neurobiol. 2010 Aug; 20(4):416-23. Mu Y, Lee SW, Gage FH. PMID: 20471243; PMCID: PMC2942965.
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Adult neurogenesis: integrating theories and separating functions. Trends Cogn Sci. 2010 Jul; 14(7):325-37. Aimone JB, Deng W, Gage FH. PMID: 20471301; PMCID: PMC2904863.
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LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci. 2010 Aug; 33(8):345-54. Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH. PMID: 20471112; PMCID: PMC2916067.
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Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet. 2010 Apr 15; 19(R1):R71-6. Marchetto MC, Winner B, Gage FH. PMID: 20418487; PMCID: PMC2875052.
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Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7963-8. Tronel S, Fabre A, Charrier V, Oliet SH, Gage FH, Abrous DN. PMID: 20375283; PMCID: PMC2867872.
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New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci. 2010 May; 11(5):339-50. Deng W, Aimone JB, Gage FH. PMID: 20354534; PMCID: PMC2886712.
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Mechanisms underlying inflammation in neurodegeneration. Cell. 2010 Mar 19; 140(6):918-34. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. PMID: 20303880; PMCID: PMC2873093.
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Molecular and cellular mechanisms contributing to the regulation, proliferation and differentiation of neural stem cells in the adult dentate gyrus. Keio J Med. 2010; 59(3):79-83. Gage FH. PMID: 20881448.
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Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal. Nat Cell Biol. 2010 Jan; 12(1):31-40; sup pp 1-9. Qu Q, Sun G, Li W, Yang S, Ye P, Zhao C, Yu RT, Gage FH, Evans RM, Shi Y. PMID: 20010817; PMCID: PMC2880892.
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Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Front Neurosci. 2009; 3:55. Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S, Williams RW. PMID: 20582282; PMCID: PMC2858614.
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[Epigenetic mechanisms regulating neural cell fate determination]. No To Hattatsu. 2009 Nov; 41(6):411-4. Nakashima K, Kohyama J, Namihira M, Gage FH, Okano H, Sawamoto K. PMID: 19928537.
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Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J Neurosci. 2009 Oct 28; 29(43):13532-42. Deng W, Saxe MD, Gallina IS, Gage FH. PMID: 19864566; PMCID: PMC2787190.
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Environmental influence on L1 retrotransposons in the adult hippocampus. Hippocampus. 2009 Oct; 19(10):1002-7. Muotri AR, Zhao C, Marchetto MC, Gage FH. PMID: 19771587; PMCID: PMC2758700.
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Making a neuron: Cdk5 in embryonic and adult neurogenesis. Trends Neurosci. 2009 Nov; 32(11):575-82. Jessberger S, Gage FH, Eisch AJ, Lagace DC. PMID: 19782409; PMCID: PMC2767479.
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Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One. 2009 Sep 18; 4(9):e7076. Marchetto MC, Yeo GW, Kainohana O, Marsala M, Gage FH, Muotri AR. PMID: 19763270; PMCID: PMC2741600.
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Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis. Cell Stem Cell. 2009 Sep 04; 5(3):310-9. Tamaki SJ, Jacobs Y, Dohse M, Capela A, Cooper JD, Reitsma M, He D, Tushinski R, Belichenko PV, Salehi A, Mobley W, Gage FH, Huhn S, Tsukamoto AS, Weissman IL, Uchida N. PMID: 19733542.
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Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis. Nat Neurosci. 2009 Sep; 12(9):1097-105. Kuwabara T, Hsieh J, Muotri A, Yeo G, Warashina M, Lie DC, Moore L, Nakashima K, Asashima M, Gage FH. PMID: 19701198; PMCID: PMC2764260.
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L1 retrotransposition in human neural progenitor cells. Nature. 2009 Aug 27; 460(7259):1127-31. Coufal NG, Garcia-Perez JL, Peng GE, Yeo GW, Mu Y, Lovci MT, Morell M, O'Shea KS, Moran JV, Gage FH. PMID: 19657334; PMCID: PMC2909034.
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A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science. 2009 Jul 10; 325(5937):210-3. Clelland CD, Choi M, Romberg C, Clemenson GD, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ. PMID: 19590004; PMCID: PMC2997634.
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Hippocampus-dependent learning is associated with adult neurogenesis in MRL/MpJ mice. Hippocampus. 2009 Jul; 19(7):658-69. Thuret S, Toni N, Aigner S, Yeo GW, Gage FH. PMID: 19140178.
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Muscle injection of AAV-NT3 promotes anatomical reorganization of CST axons and improves behavioral outcome following SCI. J Neurotrauma. 2009 Jul; 26(7):941-53. Fortun J, Puzis R, Pearse DD, Gage FH, Bunge MB. PMID: 19275471.
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GABA-cAMP response element-binding protein signaling regulates maturation and survival of newly generated neurons in the adult hippocampus. J Neurosci. 2009 Jun 24; 29(25):7966-77. Jagasia R, Steib K, Englberger E, Herold S, Faus-Kessler T, Saxe M, Gage FH, Song H, Lie DC. PMID: 19553437; PMCID: PMC2776747.
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Alpha9 integrin promotes neurite outgrowth on tenascin-C and enhances sensory axon regeneration. J Neurosci. 2009 Apr 29; 29(17):5546-57. Andrews MR, Czvitkovich S, Dassie E, Vogelaar CF, Faissner A, Blits B, Gage FH, ffrench-Constant C, Fawcett JW. PMID: 19403822; PMCID: PMC6665849.
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A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell. 2009 Apr 03; 137(1):47-59. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH, Glass CK. PMID: 19345186; PMCID: PMC2754279.
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miR-9 and TLX: chasing tails in neural stem cells. Nat Struct Mol Biol. 2009 Apr; 16(4):346-7. Denli AM, Cao X, Gage FH. PMID: 19343066.
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Notch keeps ependymal cells in line. Nat Neurosci. 2009 Mar; 12(3):243-5. Zhao C, Suh H, Gage FH. PMID: 19238183.
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Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn Mem. 2009 Feb; 16(2):147-54. Jessberger S, Clark RE, Broadbent NJ, Clemenson GD, Consiglio A, Lie DC, Squire LR, Gage FH. PMID: 19181621; PMCID: PMC2661246.
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Computational influence of adult neurogenesis on memory encoding. Neuron. 2009 Jan 29; 61(2):187-202. Aimone JB, Wiles J, Gage FH. PMID: 19186162; PMCID: PMC2670434.
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Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. J Neurosci. 2009 Jan 28; 29(4):1115-25. Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. PMID: 19176820; PMCID: PMC2768399.
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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol. 2009 Feb; 16(2):130-7. Yeo GW, Coufal NG, Liang TY, Peng GE, Fu XD, Gage FH. PMID: 19136955; PMCID: PMC2735254.
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Fate plasticity of adult hippocampal progenitors: biological relevance and therapeutic use. Trends Pharmacol Sci. 2009 Feb; 30(2):61-5. Jessberger S, Gage FH. PMID: 19135265; PMCID: PMC2752320.
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Development of a novel mouse glioma model using lentiviral vectors. Nat Med. 2009 Jan; 15(1):110-6. Marumoto T, Tashiro A, Friedmann-Morvinski D, Scadeng M, Soda Y, Gage FH, Verma IM. PMID: 19122659; PMCID: PMC2671237.
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Signaling in adult neurogenesis. Annu Rev Cell Dev Biol. 2009; 25:253-75. Suh H, Deng W, Gage FH. PMID: 19575663.
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Development of neural circuits in the adult hippocampus. Curr Top Dev Biol. 2009; 87:149-74. Li Y, Mu Y, Gage FH. PMID: 19427519.
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Genomic anatomy of the hippocampus. Neuron. 2008 Dec 26; 60(6):1010-21. Thompson CL, Pathak SD, Jeromin A, Ng LL, MacPherson CR, Mortrud MT, Cusick A, Riley ZL, Sunkin SM, Bernard A, Puchalski RB, Gage FH, Jones AR, Bajic VB, Hawrylycz MJ, Lein ES. PMID: 19109908.
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Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):649-57. Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH. PMID: 19041781.
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Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging. 2008 Dec; 23(4):684-91. Jessberger S, Gage FH. PMID: 19140640; PMCID: PMC2771615.
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YAP regulates neural progenitor cell number via the TEA domain transcription factor. Genes Dev. 2008 Dec 01; 22(23):3320-34. Cao X, Pfaff SL, Gage FH. PMID: 19015275; PMCID: PMC2600760.
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Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):18012-7. Kohyama J, Kojima T, Takatsuka E, Yamashita T, Namiki J, Hsieh J, Gage FH, Namihira M, Okano H, Sawamoto K, Nakashima K. PMID: 19004774; PMCID: PMC2584744.
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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. BMC Neurosci. 2008 Nov 12; 9:109. Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. PMID: 19014502; PMCID: PMC2596170.
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Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biol. 2008 Nov 11; 6(11):e272. Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall R, Kempermann G, Gage FH. PMID: 18998770; PMCID: PMC2581629.
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Experts provide insights into emerging field of brain and spine repair. Interview by Bridget M. Kuehn. JAMA. 2008 Sep 03; 300(9):1013-4. Gage FH, Selzer ME. PMID: 18768407.
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Epigenetic regulation of the stem cell mitogen Fgf-2 by Mbd1 in adult neural stem/progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27644-27652. Li X, Barkho BZ, Luo Y, Smrt RD, Santistevan NJ, Liu C, Kuwabara T, Gage FH, Zhao X. PMID: 18689796; PMCID: PMC2562066.
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Neurons born in the adult dentate gyrus form functional synapses with target cells. Nat Neurosci. 2008 Aug; 11(8):901-7. Toni N, Laplagne DA, Zhao C, Lombardi G, Ribak CE, Gage FH, Schinder AF. PMID: 18622400; PMCID: PMC2572641.
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Directed differentiation of hippocampal stem/progenitor cells in the adult brain. Nat Neurosci. 2008 Aug; 11(8):888-93. Jessberger S, Toni N, Clemenson GD, Ray J, Gage FH. PMID: 18587391; PMCID: PMC2795354.
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Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells. Hum Mol Genet. 2008 Apr 15; 17(R1):R67-75. Yeo GW, Coufal N, Aigner S, Winner B, Scolnick JA, Marchetto MC, Muotri AR, Carson C, Gage FH. PMID: 18632700.
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Mechanisms and functional implications of adult neurogenesis. Cell. 2008 Feb 22; 132(4):645-60. Zhao C, Deng W, Gage FH. PMID: 18295581.
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A role for adult TLX-positive neural stem cells in learning and behaviour. Nature. 2008 Feb 21; 451(7181):1004-7. Zhang CL, Zou Y, He W, Gage FH, Evans RM. PMID: 18235445.
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Identification of small molecules from human embryonic stem cells using metabolomics. Stem Cells Dev. 2007 Dec; 16(6):869-82. Cezar GG, Quam JA, Smith AM, Rosa GJ, Piekarczyk MS, Brown JF, Gage FH, Muotri AR. PMID: 18042039.
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In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus. Cell Stem Cell. 2007 Nov; 1(5):515-28. Suh H, Consiglio A, Ray J, Sawai T, D'Amour KA, Gage FH. PMID: 18371391; PMCID: PMC2185820.
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The necessary junk: new functions for transposable elements. Hum Mol Genet. 2007 Oct 15; 16 Spec No. 2:R159-67. Muotri AR, Marchetto MC, Coufal NG, Gage FH. PMID: 17911158.
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Seizure-associated, aberrant neurogenesis in adult rats characterized with retrovirus-mediated cell labeling. J Neurosci. 2007 Aug 29; 27(35):9400-7. Jessberger S, Zhao C, Toni N, Clemenson GD, Li Y, Gage FH. PMID: 17728453; PMCID: PMC6673128.
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Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter. Gene Expr Patterns. 2007 Dec; 8(1):36-46. Yao W, Nathanson J, Lian I, Gage FH, Sung LA. PMID: 17920339.
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Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol. 2007 Oct; 3(10):1951-67. Yeo GW, Xu X, Liang TY, Muotri AR, Carson CT, Coufal NG, Gage FH. PMID: 17967047; PMCID: PMC2041973.
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The glycans of stem cells. Curr Opin Chem Biol. 2007 Aug; 11(4):373-80. Lanctot PM, Gage FH, Varki AP. PMID: 17681848; PMCID: PMC2697851.
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A novel model for an older remodeler: the BAF swap in neurogenesis. Neuron. 2007 Jul 19; 55(2):171-3. Aigner S, Denli AM, Gage FH. PMID: 17640518.
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Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. J Neurosci. 2007 May 30; 27(22):5869-78. van Praag H, Lucero MJ, Yeo GW, Stecker K, Heivand N, Zhao C, Yip E, Afanador M, Schroeter H, Hammerstone J, Gage FH. PMID: 17537957; PMCID: PMC6672256.
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Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. J Neurosci. 2007 May 30; 27(22):5967-75. Jessberger S, Nakashima K, Clemenson GD, Mejia E, Mathews E, Ure K, Ogawa S, Sinton CM, Gage FH, Hsieh J. PMID: 17537967; PMCID: PMC6672253.
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Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis. Eur J Neurosci. 2007 May; 25(10):2973-81. Laplagne DA, Kamienkowski JE, Espósito MS, Piatti VC, Zhao C, Gage FH, Schinder AF. PMID: 17509085.
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Synapse formation on neurons born in the adult hippocampus. Nat Neurosci. 2007 Jun; 10(6):727-34. Toni N, Teng EM, Bushong EA, Aimone JB, Zhao C, Consiglio A, van Praag H, Martone ME, Ellisman MH, Gage FH. PMID: 17486101.
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LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet. 2007 Jul 01; 16(13):1569-77. Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV. PMID: 17468180.
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Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol Dis. 2007 Jul; 27(1):77-89. Smrt RD, Eaves-Egenes J, Barkho BZ, Santistevan NJ, Zhao C, Aimone JB, Gage FH, Zhao X. PMID: 17532643; PMCID: PMC2789309.
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Neprilysin protects neurons against Abeta peptide toxicity. Brain Res. 2007 Jun 04; 1152:191-200. El-Amouri SS, Zhu H, Yu J, Gage FH, Verma IM, Kindy MS. PMID: 17459354; PMCID: PMC2020816.
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Experience-specific functional modification of the dentate gyrus through adult neurogenesis: a critical period during an immature stage. J Neurosci. 2007 Mar 21; 27(12):3252-9. Tashiro A, Makino H, Gage FH. PMID: 17376985; PMCID: PMC6672473.
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An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5638-43. Pereira AC, Huddleston DE, Brickman AM, Sosunov AA, Hen R, McKhann GM, Sloan R, Gage FH, Brown TR, Small SA. PMID: 17374720; PMCID: PMC1838482.
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A functional study of miR-124 in the developing neural tube. Genes Dev. 2007 Mar 01; 21(5):531-6. Cao X, Pfaff SL, Gage FH. PMID: 17344415; PMCID: PMC1820895.
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Cortical area size dictates performance at modality-specific behaviors. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4153-8. Leingärtner A, Thuret S, Kroll TT, Chou SJ, Leasure JL, Gage FH, O'Leary DD. PMID: 17360492; PMCID: PMC1820724.
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Estradiol enhances neurogenesis following ischemic stroke through estrogen receptors alpha and beta. J Comp Neurol. 2007 Feb 20; 500(6):1064-75. Suzuki S, Gerhold LM, Böttner M, Rau SW, Dela Cruz C, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM. PMID: 17183542.
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Is neurogenesis reparative after status epilepticus? Epilepsia. 2007; 48 Suppl 8:69-71. Parent JM, Jessberger S, Gage FH, Gong C. PMID: 18330005.
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Spontaneous fusion and nonclonal growth of adult neural stem cells. Stem Cells. 2007 Apr; 25(4):871-4. Jessberger S, Clemenson GD, Gage FH. PMID: 17185607.
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Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2006 Dec 19; 103(51):19546-51. Miller TM, Kim SH, Yamanaka K, Hester M, Umapathi P, Arnson H, Rizo L, Mendell JR, Gage FH, Cleveland DW, Kaspar BK. PMID: 17164329; PMCID: PMC1748262.
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Integration of new neurons into functional neural networks. J Neurosci. 2006 Nov 22; 26(47):12237-41. Ramirez-Amaya V, Marrone DF, Gage FH, Worley PF, Barnes CA. PMID: 17122048; PMCID: PMC6675440.
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Functional convergence of neurons generated in the developing and adult hippocampus. PLoS Biol. 2006 Nov; 4(12):e409. Laplagne DA, Espósito MS, Piatti VC, Morgenstern NA, Zhao C, van Praag H, Gage FH, Schinder AF. PMID: 17121455; PMCID: PMC1637132.
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Stem cells: the good, bad and barely in control. Nat Med. 2006 Nov; 12(11):1237-8. Carson CT, Aigner S, Gage FH. PMID: 17088886.
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Ex vivo and in vivo gene delivery to the brain. Curr Protoc Hum Genet. 2006 Nov; Chapter 13:Unit 13.3. Suhonen J, Ray J, Blömer U, Gage FH, Kaspar B. PMID: 18428389.
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Fate of endogenous stem/progenitor cells following spinal cord injury. J Comp Neurol. 2006 Oct 01; 498(4):525-38. Horky LL, Galimi F, Gage FH, Horner PJ. PMID: 16874803; PMCID: PMC2553041.
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NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus. Nature. 2006 Aug 24; 442(7105):929-33. Tashiro A, Sandler VM, Toni N, Zhao C, Gage FH. PMID: 16906136.
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Neocortical neurogenesis in humans is restricted to development. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12564-8. Bhardwaj RD, Curtis MA, Spalding KL, Buchholz BA, Fink D, Björk-Eriksson T, Nordborg C, Gage FH, Druid H, Eriksson PS, Frisén J. PMID: 16901981; PMCID: PMC1567918.
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New regulators in adult neurogenesis and their potential role for repair. Trends Mol Med. 2006 Sep; 12(9):400-5. Jagasia R, Song H, Gage FH, Lie DC. PMID: 16890023.
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Therapeutic interventions after spinal cord injury. Nat Rev Neurosci. 2006 Aug; 7(8):628-43. Thuret S, Moon LD, Gage FH. PMID: 16858391.
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Functional and morphological effects of NG2 proteoglycan deletion on hippocampal neurogenesis. Exp Neurol. 2006 Nov; 202(1):167-78. Thallmair M, Ray J, Stallcup WB, Gage FH. PMID: 16814771.
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Generation of neuronal variability and complexity. Nature. 2006 Jun 29; 441(7097):1087-93. Muotri AR, Gage FH. PMID: 16810244.
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Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10294-10299. Suzuki A, Raya Á, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. PMID: 16801560; PMCID: PMC1502451.
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Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation. Stem Cells Dev. 2006 Jun; 15(3):407-21. Barkho BZ, Song H, Aimone JB, Smrt RD, Kuwabara T, Nakashima K, Gage FH, Zhao X. PMID: 16846377; PMCID: PMC2777811.
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Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci. 2006 Jun; 9(6):723-7. Aimone JB, Wiles J, Gage FH. PMID: 16732202.
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Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1. Genes Dev. 2006 May 15; 20(10):1308-20. Zhang CL, Zou Y, Yu RT, Gage FH, Evans RM. PMID: 16702404; PMCID: PMC1472905.
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Maintenance of embryonic stem cell pluripotency by Nanog-mediated reversal of mesoderm specification. Nat Clin Pract Cardiovasc Med. 2006 Mar; 3 Suppl 1:S114-22. Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gage FH, Rodríguez-Esteban C, Izpisúa Belmonte JC. PMID: 16501617.
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Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc Natl Acad Sci U S A. 2006 Mar 07; 103(10):3902-7. Jacobs S, Lie DC, DeCicco KL, Shi Y, DeLuca LM, Gage FH, Evans RM. PMID: 16505366; PMCID: PMC1450163.
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Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
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Differential properties of adult rat and mouse brain-derived neural stem/progenitor cells. Mol Cell Neurosci. 2006 Mar; 31(3):560-73. Ray J, Gage FH. PMID: 16426857.
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A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells. Angew Chem Int Ed Engl. 2006 Jan 16; 45(4):591-3. Warashina M, Min KH, Kuwabara T, Huynh A, Gage FH, Schultz PG, Ding S. PMID: 16323231.
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Unconventional translation of mammalian LINE-1 retrotransposons. Genes Dev. 2006 Jan 15; 20(2):210-24. Alisch RS, Garcia-Perez JL, Muotri AR, Gage FH, Moran JV. PMID: 16418485; PMCID: PMC1356112.
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Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):780-5. Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH. PMID: 16407118; PMCID: PMC1325968.
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Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci. 2006 Jan 04; 26(1):3-11. Zhao C, Teng EM, Summers RG, Ming GL, Gage FH. PMID: 16399667; PMCID: PMC6674324.
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Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur J Neurosci. 2006 Jan; 23(1):83-93. Battista D, Ferrari CC, Gage FH, Pitossi FJ. PMID: 16420418.
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Noncoding RNAs in the mammalian central nervous system. Annu Rev Neurosci. 2006; 29:77-103. Cao X, Yeo G, Muotri AR, Kuwabara T, Gage FH. PMID: 16776580.
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Retrovirus-mediated single-cell gene knockout technique in adult newborn neurons in vivo. Nat Protoc. 2006; 1(6):3049-55. Tashiro A, Zhao C, Gage FH. PMID: 17406567.
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Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation. Restor Neurol Neurosci. 2006; 24(3):147-61. Moon LD, Leasure JL, Gage FH, Bunge MB. PMID: 16873970.
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In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cereb Cortex. 2006 Nov; 16(11):1571-83. Borrell V, Kaspar BK, Gage FH, Callaway EM. PMID: 16357334.
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Development of functional human embryonic stem cell-derived neurons in mouse brain. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18644-8. Muotri AR, Nakashima K, Toni N, Sandler VM, Gage FH. PMID: 16352714; PMCID: PMC1317971.
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Attenuation of DNA damage in canine hearts preserved by continuous hypothermic perfusion. Ann Thorac Surg. 2005 Nov; 80(5):1812-20. Fitton TP, Barreiro CJ, Bonde PN, Wei C, Gage F, Rodriguez R, Conte JV. PMID: 16242460.
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Wnt signalling regulates adult hippocampal neurogenesis. Nature. 2005 Oct 27; 437(7063):1370-5. Lie DC, Colamarino SA, Song HJ, Désiré L, Mira H, Consiglio A, Lein ES, Jessberger S, Lansford H, Dearie AR, Gage FH. PMID: 16251967.
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Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol. 2005 Dec; 17(6):664-71. Hsieh J, Gage FH. PMID: 16226449.
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Neuronal and glial cell biology. Curr Opin Neurobiol. 2005 Oct; 15(5):497-9. Gage FH, McAllister AK. PMID: 16143511.
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Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci. 2005 Sep 21; 25(38):8680-5. van Praag H, Shubert T, Zhao C, Gage FH. PMID: 16177036; PMCID: PMC1360197.
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Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):14069-74. Cummings BJ, Uchida N, Tamaki SJ, Salazar DL, Hooshmand M, Summers R, Gage FH, Anderson AJ. PMID: 16172374; PMCID: PMC1216836.
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Targeted expression of IGF-1 in the central nervous system fails to protect mice from experimental autoimmune encephalomyelitis. J Neuroimmunol. 2005 Nov; 168(1-2):40-5. Genoud S, Maricic I, Kumar V, Gage FH. PMID: 16120466.
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A small gem with great powers: geminin keeps neural progenitors thriving. Dev Cell. 2005 Aug; 9(2):171-2. Aigner S, Gage FH. PMID: 16054024.
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Proliferation, migration, neuronal differentiation, and long-term survival of new cells in the adult zebrafish brain. J Comp Neurol. 2005 Aug 01; 488(3):290-319. Zupanc GK, Hinsch K, Gage FH. PMID: 15952170.
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Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature. 2005 Jun 16; 435(7044):903-10. Muotri AR, Chu VT, Marchetto MC, Deng W, Moran JV, Gage FH. PMID: 15959507.
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Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19; 46(4):569-79. Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF. PMID: 15944126.
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Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):773-6. Miller TM, Kaspar BK, Kops GJ, Yamanaka K, Christian LJ, Gage FH, Cleveland DW. PMID: 15852369; PMCID: PMC1351126.
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Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann Neurol. 2005 May; 57(5):649-55. Kaspar BK, Frost LM, Christian L, Umapathi P, Gage FH. PMID: 15852403.
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Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. J Comp Neurol. 2005 Apr 25; 485(1):1-10. Lein ES, Callaway EM, Albright TD, Gage FH. PMID: 15776443.
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Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods. 2005 May; 2(5):363-70. Scheel JR, Ray J, Gage FH, Barlow C. PMID: 15846364.
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The NRSE smRNA specifies the fate of adult hippocampal neural stem cells. Nucleic Acids Symp Ser (Oxf). 2005; (49):87-8. Kuwabara T, Hsieh J, Nakashima K, Warashina M, Taira K, Gage FH. PMID: 17150646.
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An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther. 2004 Dec; 11(23):1713-23. Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. PMID: 15483670.
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A role for bone marrow-derived cells in the vasculature of noninjured CNS. Blood. 2005 Mar 15; 105(6):2400-2. Galimi F, Summers RG, van Praag H, Verma IM, Gage FH. PMID: 15572598.
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Intracerebral transplantation of adult mouse neural progenitor cells into the Niemann-Pick-A mouse leads to a marked decrease in lysosomal storage pathology. J Neurosci. 2004 Nov 24; 24(47):10642-51. Shihabuddin LS, Numan S, Huff MR, Dodge JC, Clarke J, Macauley SL, Yang W, Taksir TV, Parsons G, Passini MA, Gage FH, Stewart GR. PMID: 15564580; PMCID: PMC6730128.
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Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16659-64. Hsieh J, Nakashima K, Kuwabara T, Mejia E, Gage FH. PMID: 15537713; PMCID: PMC527137.
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Microfabricated platform for studying stem cell fates. Biotechnol Bioeng. 2004 Nov 05; 88(3):399-415. Chin VI, Taupin P, Sanga S, Scheel J, Gage FH, Bhatia SN. PMID: 15486946.
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Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14835-40. Consiglio A, Gritti A, Dolcetta D, Follenzi A, Bordignon C, Gage FH, Vescovi AL, Naldini L. PMID: 15466696; PMCID: PMC522006.
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Epigenetic control of neural stem cell fate. Curr Opin Genet Dev. 2004 Oct; 14(5):461-9. Hsieh J, Gage FH. PMID: 15380235.
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A hypothesis about the role of adult neurogenesis in hippocampal function. Physiology (Bethesda). 2004 Oct; 19:253-61. Schinder AF, Gage FH. PMID: 15381753.
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Optimizing donor heart outcome after prolonged storage with endothelial function analysis and continuous perfusion. Ann Thorac Surg. 2004 Oct; 78(4):1362-70;; discussion 1362-70. Poston RS, Gu J, Prastein D, Gage F, Hoffman JW, Kwon M, Azimzadeh A, Pierson RN, Griffith BP. PMID: 15464500.
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Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature. 2004 Jul 15; 430(6997):350-6. Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH. PMID: 15254537.
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Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci. 2004 Jun 16; 24(24):5459-66. Brandon EP, Mellott T, Pizzo DP, Coufal N, D'Amour KA, Gobeske K, Lortie M, López-Coviella I, Berse B, Thal LJ, Gage FH, Blusztajn JK. PMID: 15201317; PMCID: PMC6729318.
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Structural plasticity of the adult brain. Dialogues Clin Neurosci. 2004 Jun; 6(2):135-41. Gage FH. PMID: 22034393; PMCID: PMC3181802.
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Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics. J Neurosci Methods. 2004 May 30; 135(1-2):27-33. Aimone JB, Gage FH. PMID: 15020086.
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Neuroscience. Cellular interactions in the stem cell niche. Science. 2004 May 28; 304(5675):1253-5. Wurmser AE, Palmer TD, Gage FH. PMID: 15166350.
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Defining a molecular atlas of the hippocampus using DNA microarrays and high-throughput in situ hybridization. J Neurosci. 2004 Apr 14; 24(15):3879-89. Lein ES, Zhao X, Gage FH. PMID: 15084669; PMCID: PMC6729356.
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Functional significance of adult neurogenesis. Curr Opin Neurobiol. 2004 Apr; 14(2):186-91. Kempermann G, Wiskott L, Gage FH. PMID: 15082323.
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Novel neuronal phenotypes from neural progenitor cells. J Neurosci. 2004 Mar 24; 24(12):2886-97. Markakis EA, Palmer TD, Randolph-Moore L, Rakic P, Gage FH. PMID: 15044527; PMCID: PMC3242437.
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A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell. 2004 Mar 19; 116(6):779-93. Kuwabara T, Hsieh J, Nakashima K, Taira K, Gage FH. PMID: 15035981.
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IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J Cell Biol. 2004 Jan 05; 164(1):111-22. Hsieh J, Aimone JB, Kaspar BK, Kuwabara T, Nakashima K, Gage FH. PMID: 14709544; PMCID: PMC2171962.
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Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci. 2004; 22(1-2):5-11. Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. PMID: 14742905.
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Neurogenesis in the adult brain: new strategies for central nervous system diseases. Annu Rev Pharmacol Toxicol. 2004; 44:399-421. Lie DC, Song H, Colamarino SA, Ming GL, Gage FH. PMID: 14744252.
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Embryonic stem cells: staying plastic on plastic. Nat Med. 2004 Jan; 10(1):23-4. Nakashima K, Colamarino S, Gage FH. PMID: 14702626.
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Neurogenesis and neuroadaptation. Neuromolecular Med. 2004; 5(1):1-9. Schaffer DV, Gage FH. PMID: 15001808.
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Expression and function of orphan nuclear receptor TLX in adult neural stem cells. Nature. 2004 Jan 01; 427(6969):78-83. Shi Y, Chichung Lie D, Taupin P, Nakashima K, Ray J, Yu RT, Gage FH, Evans RM. PMID: 14702088.
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Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004; 124(1):71-9. Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. PMID: 14960340.
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Impact of 24 h continuous hypothermic perfusion on heart preservation by assessment of oxidative stress. Clin Transplant. 2004; 18 Suppl 12:22-7. Fitton TP, Wei C, Lin R, Bethea BT, Barreiro CJ, Amado L, Gage F, Hare J, Baumgartner WA, Conte JV. PMID: 15217403.
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Vibrating in the background. Nat Genet. 2003 Nov; 35(3):205-7. Muotri AR, Gage FH. PMID: 14593403.
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Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running. Behav Neurosci. 2003 Oct; 117(5):1006-16. Rhodes JS, van Praag H, Jeffrey S, Girard I, Mitchell GS, Garland T, Gage FH. PMID: 14570550.
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Survival and differentiation of adult rat-derived neural progenitor cells transplanted to the striatum of hemiparkinsonian rats. Exp Neurol. 2003 Oct; 183(2):653-64. Dziewczapolski G, Lie DC, Ray J, Gage FH, Shults CW. PMID: 14552907.
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Chronic neurotrophin-3 strengthens synaptic connections to motoneurons in the neonatal rat. J Neurosci. 2003 Sep 24; 23(25):8706-12. Arvanian VL, Horner PJ, Gage FH, Mendell LM. PMID: 14507970; PMCID: PMC6740423.
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Brain, repair yourself. Sci Am. 2003 Sep; 289(3):46-53. Gage FH. PMID: 12951827.
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IGF-I has a direct proliferative effect in adult hippocampal progenitor cells. Mol Cell Neurosci. 2003 Sep; 24(1):23-40. Aberg MA, Aberg ND, Palmer TD, Alborn AM, Carlsson-Skwirut C, Bang P, Rosengren LE, Olsson T, Gage FH, Eriksson PS. PMID: 14550766.
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Genetic and functional differences between multipotent neural and pluripotent embryonic stem cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11866-72. D'Amour KA, Gage FH. PMID: 12923297; PMCID: PMC304100.
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Stem cells at the dawn of the 21st century. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11817-8. Gage FH, Verma IM. PMID: 12915737; PMCID: PMC304091.
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Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 2003 Aug 08; 301(5634):839-42. Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH. PMID: 12907804.
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Acetylcholine-secreting cells improve age-induced memory deficits. Mol Ther. 2003 Jul; 8(1):51-61. Dickinson-Anson H, Winkler J, Fisher LJ, Song HJ, Poo Mm, Gage FH. PMID: 12842428.
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The hazards of basing acceptance of cadaveric renal allografts on pulsatile perfusion parameters alone. Transplantation. 2003 Jun 27; 75(12):2029-33. Sonnenday CJ, Cooper M, Kraus E, Gage F, Handley C, Montgomery RA. PMID: 12829906.
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A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003 Jun 15; 23(12):5031-40. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. PMID: 12832526; PMCID: PMC6741202.
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An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues. Nucleic Acids Res. 2003 May 15; 31(10):e57. Scheel JR, Garrett LJ, Allen DM, Carter TA, Randolph-Moore L, Gambello MJ, Gage FH, Wynshaw-Boris A, Barlow C. PMID: 12736323; PMCID: PMC156060.
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Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6777-82. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage FH. PMID: 12748381; PMCID: PMC164523.
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Stem cells. Setting standards for human embryonic stem cells. Science. 2003 May 09; 300(5621):913-6. Brivanlou AH, Gage FH, Jaenisch R, Jessell T, Melton D, Rossant J. PMID: 12738841.
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Expression of cytokines by multipotent neural progenitor cells. Cytokine. 2003 May; 22(3-4):101-6. Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage FH, Young MJ, Berman MA. PMID: 12849709.
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Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis. Eur J Neurosci. 2003 May; 17(10):2042-6. Brown J, Cooper-Kuhn CM, Kempermann G, Van Praag H, Winkler J, Gage FH, Kuhn HG. PMID: 12786970.
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The immunological properties of adult hippocampal progenitor cells. Vision Res. 2003 Apr; 43(8):947-56. Klassen H, Imfeld KL, Ray J, Young MJ, Gage FH, Berman MA. PMID: 12668064.
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Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci. 2003 Mar 15; 23(6):1992-6. Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. PMID: 12657655; PMCID: PMC6742010.
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Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci. 2003 Jan 15; 23(2):539-49. Brandon EP, Lin W, D'Amour KA, Pizzo DP, Dominguez B, Sugiura Y, Thode S, Ko CP, Thal LJ, Gage FH, Lee KF. PMID: 12533614; PMCID: PMC6741871.
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Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development. 2003 Jan; 130(2):391-9. Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH. PMID: 12466205.
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Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nat Neurosci. 2003 Jan; 6(1):21-7. Lai K, Kaspar BK, Gage FH, Schaffer DV. PMID: 12469128.
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Regeneration in the adult and aging brain. Arch Neurol. 2002 Nov; 59(11):1717-20. Horner PJ, Gage FH. PMID: 12433257.
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Engraftment of sorted/expanded human central nervous system stem cells from fetal brain. J Neurosci Res. 2002 Sep 15; 69(6):976-86. Tamaki S, Eckert K, He D, Sutton R, Doshe M, Jain G, Tushinski R, Reitsma M, Harris B, Tsukamoto A, Gage F, Weissman I, Uchida N. PMID: 12205691.
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Adult neurogenesis and neural stem cells of the central nervous system in mammals. J Neurosci Res. 2002 Sep 15; 69(6):745-9. Taupin P, Gage FH. PMID: 12205667.
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The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci. 2002 Aug 01; 22(15):6639-49. Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH. PMID: 12151543; PMCID: PMC6758128.
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Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol. 2002 Aug; 52(2):135-43. Kempermann G, Gast D, Gage FH. PMID: 12210782.
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Defining the NG2-expressing cell of the adult CNS. J Neurocytol. 2002 Jul-Aug; 31(6-7):469-80. Horner PJ, Thallmair M, Gage FH. PMID: 14501217.
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Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci. 2002 Jul; 16(1):129-36. Kempermann G, Gage FH. PMID: 12153537.
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Astroglia induce neurogenesis from adult neural stem cells. Nature. 2002 May 02; 417(6884):39-44. Song H, Stevens CF, Gage FH. PMID: 11986659.
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Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons. Nat Neurosci. 2002 May; 5(5):438-45. Song HJ, Stevens CF, Gage FH. PMID: 11953752.
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Stem cells: cell fusion causes confusion. Nature. 2002 Apr 04; 416(6880):485-7. Wurmser AE, Gage FH. PMID: 11932725.
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Genetic influence on phenotypic differentiation in adult hippocampal neurogenesis. Brain Res Dev Brain Res. 2002 Mar 31; 134(1-2):1-12. Kempermann G, Gage FH. PMID: 11947932.
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Are somatic stem cells pluripotent or lineage-restricted? Nat Med. 2002 Mar; 8(3):213-4. D'Amour KA, Gage FH. PMID: 11875484.
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Genetics of childhood disorders: XXXVI. Stem cell research, part 1: New neurons in the adult brain. J Am Acad Child Adolesc Psychiatry. 2002 Mar; 41(3):354-6. van Praag H, Gage FH. PMID: 11886031.
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Functional neurogenesis in the adult hippocampus. Nature. 2002 Feb 28; 415(6875):1030-4. van Praag H, Schinder AF, Christie BR, Toni N, Palmer TD, Gage FH. PMID: 11875571; PMCID: PMC9284568.
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Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2320-5. Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. PMID: 11842206; PMCID: PMC122363.
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Neurogenesis in the adult brain. J Neurosci. 2002 Feb 01; 22(3):612-3. Gage FH. PMID: 11826087; PMCID: PMC6758482.
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Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. J Neurosci. 2002 Jan 15; 22(2):486-92. Vallières L, Campbell IL, Gage FH, Sawchenko PE. PMID: 11784794; PMCID: PMC6758670.
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Targeted retrograde gene delivery for neuronal protection. Mol Ther. 2002 Jan; 5(1):50-6. Kaspar BK, Erickson D, Schaffer D, Hinh L, Gage FH, Peterson DA. PMID: 11786045.
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Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol. 2001 Dec 17; 441(3):187-96. Zhao X, Lein ES, He A, Smith SC, Aston C, Gage FH. PMID: 11745644.
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Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11450-5. Pfeifer A, Brandon EP, Kootstra N, Gage FH, Verma IM. PMID: 11553794; PMCID: PMC58750.
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Chipping away at stem cells. Proc Natl Acad Sci U S A. 2001 Jul 03; 98(14):7652-3. Chu VT, Gage FH. PMID: 11438717; PMCID: PMC35394.
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Sonic hedgehog facilitates dopamine differentiation in the presence of a mesencephalic glial cell line. J Neurosci. 2001 Jun 15; 21(12):4326-35. Matsuura N, Lie DC, Hoshimaru M, Asahi M, Hojo M, Ishizaki R, Hashimoto N, Noji S, Ohuchi H, Yoshioka H, Gage FH. PMID: 11404418; PMCID: PMC6762741.
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Are drug targets missed owing to lack of physical activity? - Reply. Drug Discov Today. 2001 Jun 01; 6(12):615-617. van Praag H, Barlow C, Gage FH. PMID: 11408195.
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Cell culture. Progenitor cells from human brain after death. Nature. 2001 May 03; 411(6833):42-3. Palmer TD, Schwartz PH, Taupin P, Kaspar B, Stein SA, Gage FH. PMID: 11333968.
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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J Cell Biol. 2001 Apr 16; 153(2):283-94. Suhr ST, Senut MC, Whitelegge JP, Faull KF, Cuizon DB, Gage FH. PMID: 11309410; PMCID: PMC2169460.
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Can stem cells cross lineage boundaries? Nat Med. 2001 Apr; 7(4):393-5. Anderson DJ, Gage FH, Weissman IL. PMID: 11283651.
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Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev. 2001 Mar 01; 15(5):554-66. Allen DM, van Praag H, Ray J, Weaver Z, Winrow CJ, Carter TA, Braquet R, Harrington E, Ried T, Brown KD, Gage FH, Barlow C. PMID: 11238376; PMCID: PMC312645.
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Construction of cells expressing neurotrophins. Methods Mol Biol. 2001; 169:115-33. Ray J, Gage FH. PMID: 11142007.
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Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14720-5. Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL. PMID: 11121071; PMCID: PMC18985.
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Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci. 2000 Dec 01; 20(23):8727-35. Shihabuddin LS, Horner PJ, Ray J, Gage FH. PMID: 11102479; PMCID: PMC6773057.
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Neural consequences of environmental enrichment. Nat Rev Neurosci. 2000 Dec; 1(3):191-8. van Praag H, Kempermann G, Gage FH. PMID: 11257907.
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Fibroblast growth factor-2-producing fibroblasts protect the nigrostriatal dopaminergic system from 6-hydroxydopamine. Brain Res. 2000 Nov 17; 883(2):192-204. Shults CW, Ray J, Tsuboi K, Gage FH. PMID: 11074048.
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FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron. 2000 Nov; 28(2):385-97. Taupin P, Ray J, Fischer WH, Suhr ST, Hakansson K, Grubb A, Gage FH. PMID: 11144350.
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Regenerating the damaged central nervous system. Nature. 2000 Oct 26; 407(6807):963-70. Horner PJ, Gage FH. PMID: 11069169.
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Structural plasticity: cause, result, or correlate of depression. Biol Psychiatry. 2000 Oct 15; 48(8):713-4. Gage FH. PMID: 11063967.
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Vascular niche for adult hippocampal neurogenesis. J Comp Neurol. 2000 Oct 02; 425(4):479-94. Palmer TD, Willhoite AR, Gage FH. PMID: 10975875.
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Neurobiology of disease. Curr Opin Neurobiol. 2000 Oct; 10(5):655-60. Zoghbi HY, Gage FH, Choi DW. PMID: 11084329.
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Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci. 2000 Sep; 16(3):197-205. Young MJ, Ray J, Whiteley SJ, Klassen H, Gage FH. PMID: 10995547.
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Genome and gene therapy. Mol Ther. 2000 Aug; 2(2):95. Verma IM, Gage FH. PMID: 10947933.
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Lentiviral vectors: regulated gene expression. Mol Ther. 2000 Jun; 1(6):516-21. Kafri T, van Praag H, Gage FH, Verma IM. PMID: 10933976.
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Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci. 2000 Mar 15; 20(6):2218-28. Horner PJ, Power AE, Kempermann G, Kuhn HG, Palmer TD, Winkler J, Thal LJ, Gage FH. PMID: 10704497; PMCID: PMC6772504.
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Mammalian neural stem cells. Science. 2000 Feb 25; 287(5457):1433-8. Gage FH. PMID: 10688783.
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Activity-dependent regulation of neuronal plasticity and self repair. Prog Brain Res. 2000; 127:35-48. Kempermann G, van Praag H, Gage FH. PMID: 11142036.
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Intraneuronal aggregate formation and cell death after viral expression of expanded polyglutamine tracts in the adult rat brain. J Neurosci. 2000 Jan 01; 20(1):219-29. Senut MC, Suhr ST, Kaspar B, Gage FH. PMID: 10627599; PMCID: PMC6774116.
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Neurogenesis in the adult hippocampus. Novartis Found Symp. 2000; 231:220-35; discussion 235-41, 302-6. Kempermann G, Gage FH. PMID: 11131541.
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Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13920-5. Spain BH, Larson CJ, Shihabuddin LS, Gage FH, Verma IM. PMID: 10570174; PMCID: PMC24166.
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Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999 Nov 09; 96(23):13427-31. van Praag H, Christie BR, Sejnowski TJ, Gage FH. PMID: 10557337; PMCID: PMC23964.
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The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease. Mol Med Today. 1999 Nov; 5(11):474-80. Shihabuddin LS, Palmer TD, Gage FH. PMID: 10529788.
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Generation and analysis of GluR5(Q636R) kainate receptor mutant mice. J Neurosci. 1999 Oct 15; 19(20):8757-64. Sailer A, Swanson GT, Pérez-Otaño I, O'Leary L, Malkmus SA, Dyck RH, Dickinson-Anson H, Schiffer HH, Maron C, Yaksh TL, Gage FH, O'Gorman S, Heinemann SF. PMID: 10516295; PMCID: PMC6782774.
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Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci. 1999 Oct 01; 19(19):8487-97. Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH. PMID: 10493749; PMCID: PMC6783019.
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Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10893-8. Smith DE, Roberts J, Gage FH, Tuszynski MH. PMID: 10485922; PMCID: PMC17979.
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Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development. 1999 Sep; 126(18):4017-26. Sakurada K, Ohshima-Sakurada M, Palmer TD, Gage FH. PMID: 10457011.
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Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol. 1999 Sep; 73(9):7812-6. Takahashi M, Miyoshi H, Verma IM, Gage FH. PMID: 10438872; PMCID: PMC104309.
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Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp Neurol. 1999 May; 157(1):19-42. Steward O, Schauwecker PE, Guth L, Zhang Z, Fujiki M, Inman D, Wrathall J, Kempermann G, Gage FH, Saatman KE, Raghupathi R, McIntosh T. PMID: 10222106.
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New nerve cells for the adult brain. Sci Am. 1999 May; 280(5):48-53. Kempermann G, Gage FH. PMID: 10231988.
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Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol. 1999 Apr 19; 406(4):449-60. Markakis EA, Gage FH. PMID: 10205022.
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Repression of human fibroblast growth factor 2 by a novel transcription factor. J Biol Chem. 1999 Apr 09; 274(15):10382-7. Ueba T, Kaspar B, Zhao X, Gage FH. PMID: 10187827.
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Prenatal gene therapy: can the technical hurdles be overcome? Mol Med Today. 1999 Apr; 5(4):152-6. Senut MC, Gage FH. PMID: 10203747.
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Gene therapy in the central nervous system: the use of recombinant retroviruses. Arch Neurol. 1999 Mar; 56(3):287-92. Suhr ST, Gage FH. PMID: 10190818.
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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999 Mar; 2(3):266-70. van Praag H, Kempermann G, Gage FH. PMID: 10195220.
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Central neuronal loss and behavioral impairment in mice lacking neurotrophin receptor p75. J Comp Neurol. 1999 Feb 01; 404(1):1-20. Peterson DA, Dickinson-Anson HA, Leppert JT, Lee KF, Gage FH. PMID: 9886021.
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Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration. Exp Neurol. 1999 Jan; 155(1):59-64. Mandel RJ, Gage FH, Clevenger DG, Spratt SK, Snyder RO, Leff SE. PMID: 9918705.
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Stem cell technology for basic science and clinical applications. Arch Neurol. 1999 Jan; 56(1):29-32. Shihabuddin LS, Ray J, Gage FH. PMID: 9923758.
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Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol. 1999 Jan; 38(1):65-81. Takahashi J, Palmer TD, Gage FH. PMID: 10027563.
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Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. Hippocampus. 1999; 9(3):321-32. Kempermann G, Gage FH. PMID: 10401646.
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A packaging cell line for lentivirus vectors. J Virol. 1999 Jan; 73(1):576-84. Kafri T, van Praag H, Ouyang L, Gage FH, Verma IM. PMID: 9847362; PMCID: PMC103863.
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Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci. 1998 Dec; 12(6):340-8. Takahashi M, Palmer TD, Takahashi J, Gage FH. PMID: 9888988.
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An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron. 1998 Dec; 21(6):1353-61. Chiang MY, Misner D, Kempermann G, Schikorski T, Giguère V, Sucov HM, Gage FH, Stevens CF, Evans RM. PMID: 9883728.
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Neurogenesis in the adult human hippocampus. Nat Med. 1998 Nov; 4(11):1313-7. Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH. PMID: 9809557.
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Stem cells of the central nervous system. Curr Opin Neurobiol. 1998 Oct; 8(5):671-6. Gage FH. PMID: 9811627.
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[New nerve cells for the adult brain. Adult neurogenesis and stem cell concepts in neurologic research]. Nervenarzt. 1998 Oct; 69(10):851-7. Kempermann G, Kuhn HG, Winkler J, Gage FH. PMID: 9834473.
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Development of a self-inactivating lentivirus vector. J Virol. 1998 Oct; 72(10):8150-7. Miyoshi H, Blömer U, Takahashi M, Gage FH, Verma IM. PMID: 9733856; PMCID: PMC110156.
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Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation. J Comp Neurol. 1998 Sep 14; 399(1):1-19. Aubert I, Ridet JL, Schachner M, Rougon G, Gage FH. PMID: 9725697.
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Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J Neurosci. 1998 Sep 01; 18(17):6871-81. Berger F, Gage FH, Vijayaraghavan S. PMID: 9712657; PMCID: PMC6792979.
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Multipotent progenitor cells in the adult dentate gyrus. J Neurobiol. 1998 Aug; 36(2):249-66. Gage FH, Kempermann G, Palmer TD, Peterson DA, Ray J. PMID: 9712308.
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Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci. 1998 Jul 15; 18(14):5354-65. McTigue DM, Horner PJ, Stokes BT, Gage FH. PMID: 9651218; PMCID: PMC6793495.
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High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc Natl Acad Sci U S A. 1998 Jul 07; 95(14):7999-8004. Suhr ST, Gil EB, Senut MC, Gage FH. PMID: 9653129; PMCID: PMC20918.
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Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol. 1998 Jul 30-Aug 13; 8(16):939-42. Kempermann G, Brandon EP, Gage FH. PMID: 9707406.
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Cholinergic strategies for Alzheimer's disease. J Mol Med (Berl). 1998 Jul; 76(8):555-67. Winkler J, Thal LJ, Gage FH, Fisher LJ. PMID: 9694432.
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Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion. Neuroscience. 1998 Jun; 84(3):771-81. Dickinson-Anson H, Aubert I, Gage FH, Fisher LJ. PMID: 9579782.
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Closer to neurogenesis in adult humans. Nat Med. 1998 May; 4(5):555-7. Kempermann G, Gage FH. PMID: 9585224.
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Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci. 1998 May 01; 18(9):3206-12. Kempermann G, Kuhn HG, Gage FH. PMID: 9547229; PMCID: PMC6792643.
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Cell therapy. Nature. 1998 Apr 30; 392(6679 Suppl):18-24. Gage FH. PMID: 9579857.
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Gene transfer to the rodent placenta in situ. A new strategy for delivering gene products to the fetus. J Clin Invest. 1998 Apr 15; 101(8):1565-71. Senut MC, Suhr ST, Gage FH. PMID: 9541485; PMCID: PMC508736.
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Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature. 1998 Apr 09; 392(6676):601-5. Mulle C, Sailer A, Pérez-Otaño I, Dickinson-Anson H, Castillo PE, Bureau I, Maron C, Gage FH, Mann JR, Bettler B, Heinemann SF. PMID: 9580260.
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Bcl-xL protects adult septal cholinergic neurons from axotomized cell death. Proc Natl Acad Sci U S A. 1998 Mar 03; 95(5):2603-8. Blömer U, Kafri T, Randolph-Moore L, Verma IM, Gage FH. PMID: 9482933; PMCID: PMC19429.
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Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997 Dec; 20(12):570-7. Ridet JL, Malhotra SK, Privat A, Gage FH. PMID: 9416670.
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FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. Exp Neurol. 1997 Dec; 148(2):577-86. Shihabuddin LS, Ray J, Gage FH. PMID: 9417834.
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Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet. 1997 Nov; 17(3):314-7. Kafri T, Blömer U, Peterson DA, Gage FH, Verma IM. PMID: 9354796.
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Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10319-23. Miyoshi H, Takahashi M, Gage FH, Verma IM. PMID: 9294208; PMCID: PMC23360.
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Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A. 1997 Sep 16; 94(19):10409-14. Kempermann G, Kuhn HG, Gage FH. PMID: 9294224; PMCID: PMC23376.
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Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol. 1997 Sep; 71(9):6641-9. Blömer U, Naldini L, Kafri T, Trono D, Verma IM, Gage FH. PMID: 9261386; PMCID: PMC191942.
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Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75. Science. 1997 Aug 08; 277(5327):837-9. Peterson DA, Leppert JT, Lee KF, Gage FH. PMID: 9273702.
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Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci. 1997 Aug 01; 17(15):5820-9. Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. PMID: 9221780; PMCID: PMC6573198.
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Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci. 1997 Jul 15; 17(14):5560-72. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH. PMID: 9204937; PMCID: PMC6793805.
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Potential effect of cytokines on transgene expression in primary fibroblasts implanted into the rat brain. Brain Res Mol Brain Res. 1997 Jul; 47(1-2):195-201. Schinstine M, Ray J, Gage FH. PMID: 9221917.
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Bipotent progenitor cell lines from the human CNS. Nat Biotechnol. 1997 Jun; 15(6):574-80. Sah DW, Ray J, Gage FH. PMID: 9181582.
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More hippocampal neurons in adult mice living in an enriched environment. Nature. 1997 Apr 03; 386(6624):493-5. Kempermann G, Kuhn HG, Gage FH. PMID: 9087407.
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Endogenous FGF-2 is important for cholinergic sprouting in the denervated hippocampus. J Neurosci. 1997 Apr 01; 17(7):2499-511. Fagan AM, Suhr ST, Lucidi-Phillipi CA, Peterson DA, Holtzman DM, Gage FH. PMID: 9065510; PMCID: PMC6573508.
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Application of ex vivo gene therapy in the treatment of Parkinson's disease. Exp Neurol. 1997 Mar; 144(1):82-91. Raymon HK, Thode S, Gage FH. PMID: 9126156.
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Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann Neurol. 1997 Jan; 41(1):82-93. Winkler J, Ramirez GA, Kuhn HG, Peterson DA, Day-Lollini PA, Stewart GR, Tuszynski MH, Gage FH, Thal LJ. PMID: 9005869.
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The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci. 1997; 8(6):389-404. Palmer TD, Takahashi J, Gage FH. PMID: 9143557.
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Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cells in vitro. J Neurobiol. 1997 Jan; 32(1):95-110. Sah DW, Ray J, Gage FH. PMID: 8989666.
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Intracerebral xenografts: Sertoli cells to the rescue? Nat Biotechnol. 1996 Dec; 14(13):1650-1. Senut MC, Suhr ST, Gage FH. PMID: 9634841.
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Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature. 1996 Oct 17; 383(6601):624-7. Suhonen JO, Peterson DA, Ray J, Gage FH. PMID: 8857538.
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Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11382-8. Naldini L, Blömer U, Gage FH, Trono D, Verma IM. PMID: 8876144; PMCID: PMC38066.
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Constitutive retinoid receptors expressed from adenovirus vectors that specifically activate chromosomal target genes required for differentiation of promyelocytic leukemia and teratocarcinoma cells. J Virol. 1996 Oct; 70(10):7182-9. Lipkin SM, Grider TL, Heyman RA, Glass CK, Gage FH. PMID: 8794365; PMCID: PMC190771.
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Long-term survival of transplanted basal forebrain cells following in vitro propagation with fibroblast growth factor-2. Exp Neurol. 1996 Sep; 141(1):12-24. Minger SL, Fisher LJ, Ray J, Gage FH. PMID: 8797663.
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The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell. 1996 Aug 09; 86(3):465-74. Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR. PMID: 8756728.
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Sprouting adult CNS cholinergic axons express NILE and associate with astrocytic surfaces expressing neural cell adhesion molecule. J Comp Neurol. 1996 Jul 22; 371(2):287-99. Chalmers GR, Peterson DA, Gage FH. PMID: 8835733.
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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 1996 Apr 12; 272(5259):263-7. Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. PMID: 8602510.
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Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 1996 Apr; 3(4):305-14. Tuszynski MH, Roberts J, Senut MC, U HS, Gage FH. PMID: 8732162.
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Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci. 1996 Mar 15; 16(6):2027-33. Kuhn HG, Dickinson-Anson H, Gage FH. PMID: 8604047; PMCID: PMC6578509.
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TrkA activation is sufficient to rescue axotomized cholinergic neurons. Neuron. 1996 Mar; 16(3):653-63. Lucidi-Phillipi CA, Clary DO, Reichardt LF, Gage FH. PMID: 8785062; PMCID: PMC2757416.
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Grafts of fibroblasts genetically modified to secrete NGF, BDNF, NT-3, or basic FGF elicit differential responses in the adult spinal cord. Cell Transplant. 1996 Mar-Apr; 5(2):191-204. Nakahara Y, Gage FH, Tuszynski MH. PMID: 8689031.
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Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4):1518-23. Hoshimaru M, Ray J, Sah DW, Gage FH. PMID: 8643664; PMCID: PMC39972.
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Fibroblast growth factor-2 protects entorhinal layer II glutamatergic neurons from axotomy-induced death. J Neurosci. 1996 Feb 01; 16(3):886-98. Peterson DA, Lucidi-Phillipi CA, Murphy DP, Ray J, Gage FH. PMID: 8558257; PMCID: PMC6578815.
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Somatic gene therapy for nervous system disease. Ciba Found Symp. 1996; 196:85-94; discussion 94-7. Tuszynski MH, Gage FH. PMID: 8866129.
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Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol. 1996 Jan; 137(1):157-73. Tuszynski MH, Gabriel K, Gage FH, Suhr S, Meyer S, Rosetti A. PMID: 8566208.
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Applications of gene therapy to the CNS. Hum Mol Genet. 1996; 5 Spec No:1397-404. Blömer U, Naldini L, Verma IM, Trono D, Gage FH. PMID: 8875243.
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Axonal regeneration and limited functional recovery following hippocampal deafferentation. J Comp Neurol. 1995 Dec 18; 363(3):377-88. Eagle KS, Chalmers GR, Clary DO, Gage FH. PMID: 8847406.
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Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11879-83. Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJ, Suhonen JO, Peterson DA, Suhr ST, Ray J. PMID: 8524867; PMCID: PMC40506.
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FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci. 1995 Oct; 6(5):474-86. Palmer TD, Ray J, Gage FH. PMID: 8581317.
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Regeneration in the adult mammalian CNS: guided by development. Curr Opin Neurobiol. 1995 Oct; 5(5):625-35. Aubert I, Ridet JL, Gage FH. PMID: 8580714.
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Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience. 1995 Sep; 68(1):19-27. Chen KS, Masliah E, Mallory M, Gage FH. PMID: 7477924.
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Regional differences in responsiveness of adult CNS axons to grafts of cells expressing human neurotrophin 3. Exp Neurol. 1995 Sep; 135(1):36-55. Senut MC, Tuszynski MH, Raymon HK, Suhr ST, Liou NH, Jones KR, Reichardt LF, Gage FH. PMID: 7556552.
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Novel therapeutic directions for Parkinson's disease. Mol Med Today. 1995 Jul; 1(4):181-7. Fisher LJ, Gage FH. PMID: 9415155.
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Essential role of neocortical acetylcholine in spatial memory. Nature. 1995 Jun 08; 375(6531):484-7. Winkler J, Suhr ST, Gage FH, Thal LJ, Fisher LJ. PMID: 7777056.
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Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4621-5. Tuszynski MH, Gage FH. PMID: 7753852; PMCID: PMC41996.
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Adrenal chromaffin cells transdifferentiate in response to basic fibroblast growth factor and show directed outgrowth to a nerve growth factor source in vivo. Exp Neurol. 1995 May; 133(1):32-42. Chalmers GR, Fisher LJ, Niijima K, Patterson PH, Gage FH. PMID: 7601261.
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Brain-derived neurotrophic factor-transduced fibroblasts: production of BDNF and effects of grafting to the adult rat brain. J Comp Neurol. 1995 Apr 10; 354(3):361-76. Lucidi-Phillipi CA, Gage FH, Shults CW, Jones KR, Reichardt LF, Kang UJ. PMID: 7608327; PMCID: PMC2710118.
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Maintaining the neuronal phenotype after injury in the adult CNS. Neurotrophic factors, axonal growth substrates, and gene therapy. Mol Neurobiol. 1995 Apr-Jun; 10(2-3):151-67. Tuszynski MH, Gage FH. PMID: 7576305.
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Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration. J Neurosci. 1995 Apr; 15(4):2819-25. Chen KS, Gage FH. PMID: 7722631; PMCID: PMC6577764.
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Radical directions in Parkinson's disease. Nat Med. 1995 Mar; 1(3):201-3. Fisher LJ, Gage FH. PMID: 7585029.
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Retrovirus-mediated expression of an artificial beta-endorphin precursor in primary fibroblasts. J Neurochem. 1995 Feb; 64(2):475-81. Beutler AS, Banck MS, Bach FW, Gage FH, Porreca F, Bilsky EJ, Yaksh TL. PMID: 7830038.
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Expression of biologically active basic fibroblast growth factor by genetically modified rat primary skin fibroblasts. J Neurochem. 1995 Feb; 64(2):503-13. Ray J, Hogg J, Beutler AS, Takayama H, Baird A, Gage FH. PMID: 7830042.
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Enhanced survival and neuronal differentiation of adrenal chromaffin cells cografted into the striatum with NGF-producing fibroblasts. J Neurosci. 1995 Feb; 15(2):1180-94. Niijima K, Chalmers GR, Peterson DA, Fisher LJ, Patterson PH, Gage FH. PMID: 7869093; PMCID: PMC6577834.
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Generation and culturing of precursor cells and neuroblasts from embryonic and adult central nervous system. Methods Enzymol. 1995; 254:20-37. Ray J, Raymon HK, Gage FH. PMID: 8531687.
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Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat Med. 1995 Jan; 1(1):53-8. Takayama H, Ray J, Raymon HK, Baird A, Hogg J, Fisher LJ, Gage FH. PMID: 7584953.
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Isolation, characterization, and use of stem cells from the CNS. Annu Rev Neurosci. 1995; 18:159-92. Gage FH, Ray J, Fisher LJ. PMID: 7605059.
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Storage, metabolism, and processing of 125I-fibroblast growth factor-2 after intracerebral injection. Brain Res. 1994 Dec 05; 665(2):285-92. Gonzalez AM, Carman LS, Ong M, Ray J, Gage FH, Shults CW, Baird A. PMID: 7895064.
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Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J Neurosci. 1994 Nov; 14(11 Pt 2):6872-85. Peterson DA, Lucidi-Phillipi CA, Eagle KL, Gage FH. PMID: 7965084; PMCID: PMC6577234.
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Disease, transplantation and regeneration. Curr Opin Neurobiol. 1994 Oct; 4(5):693-5. Choi D, Gage FH. PMID: 7849525.
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Spinal cord neuroblasts proliferate in response to basic fibroblast growth factor. J Neurosci. 1994 Jun; 14(6):3548-64. Ray J, Gage FH. PMID: 8207471; PMCID: PMC6576944.
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Intracerebral transplantation: basic and clinical applications to the neostriatum. FASEB J. 1994 May; 8(8):489-96. Fisher LJ, Gage FH. PMID: 8181667.
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Grafting of nerve growth factor-producing fibroblasts reduces behavioral deficits in rats with lesions of the nucleus basalis magnocellularis. Neuroscience. 1994 May; 60(2):299-309. Dekker AJ, Winkler J, Ray J, Thal LJ, Gage FH. PMID: 8072685.
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Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain. J Comp Neurol. 1994 Apr 01; 342(1):69-77. Beeson JG, Shelton ER, Chan HW, Gage FH. PMID: 8207128.
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Differential distribution of amyloid protein precursor immunoreactivity in the rat brain studied by using five different antibodies. J Comp Neurol. 1994 Apr 01; 342(1):78-96. Beeson JG, Shelton ER, Chan HW, Gage FH. PMID: 8207129.
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Effects of brain-derived neurotrophic factor and nerve growth factor on remaining neurons in the lesioned nucleus basalis magnocellularis. Brain Res. 1994 Mar 07; 639(1):149-55. Dekker AJ, Fagan AM, Gage FH, Thal LJ. PMID: 8180830.
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Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol. 1994 Mar; 126(1):1-14. Tuszynski MH, Peterson DA, Ray J, Baird A, Nakahara Y, Gage FH. PMID: 8157119.
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Mechanisms of sprouting in the adult central nervous system: cellular responses in areas of terminal degeneration and reinnervation in the rat hippocampus. Neuroscience. 1994 Feb; 58(4):705-25. Fagan AM, Gage FH. PMID: 8190252.
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Neurotrophic factors and diseases of the nervous system. Ann Neurol. 1994; 35 Suppl:S9-12. Tuszynski MH, Gage FH. PMID: 8185304.
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Neuronal stem cells: their characterization and utilization. Neurobiol Aging. 1994; 15 Suppl 2:S191. Gage FH. PMID: 7700451.
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Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 1993 Dec; 43(12):2668-73. Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. PMID: 8255474.
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Regulation of dopamine production by genetically modified primary fibroblasts. J Neurosci. 1993 Dec; 13(12):5203-11. Kang UJ, Fisher LJ, Joh TH, O'Malley KL, Gage FH. PMID: 7902865; PMCID: PMC6576430.
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Thymidine kinase-mediated killing of rat brain tumors. J Neurosurg. 1993 Nov; 79(5):729-35. Barba D, Hardin J, Ray J, Gage FH. PMID: 8410252.
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Gene therapy for neurologic disease. Arch Neurol. 1993 Nov; 50(11):1252-68. Suhr ST, Gage FH. PMID: 8215983.
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In vivo production and release of acetylcholine from primary fibroblasts genetically modified to express choline acetyltransferase. J Neurochem. 1993 Oct; 61(4):1323-32. Fisher LJ, Schinstine M, Salvaterra P, Dekker AJ, Thal L, Gage FH. PMID: 8376990.
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Cells engineered to produce acetylcholine: therapeutic potential for Alzheimer's disease. Ann N Y Acad Sci. 1993 Sep 24; 695:278-84. Fisher LJ, Raymon HK, Gage FH. PMID: 8239296.
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Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats. Neurobiol Aging. 1993 Sep-Oct; 14(5):457-70. Armstrong DM, Sheffield R, Buzsaki G, Chen KS, Hersh LB, Nearing B, Gage FH. PMID: 8247228.
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Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spatial memory task. Neurobiol Aging. 1993 Sep-Oct; 14(5):487-97. Nilsson OG, Gage FH. PMID: 8247231.
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Alzheimer's disease and spirochetes; a questionable relationship. Neuroreport. 1993 Jul; 4(7):840. Hammond RR, Gage FH, Terry RD. PMID: 8369470.
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Grafting in the mammalian central nervous system. Physiol Rev. 1993 Jul; 73(3):583-616. Fisher LJ, Gage FH. PMID: 8332639.
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Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3602-6. Ray J, Peterson DA, Schinstine M, Gage FH. PMID: 8475109; PMCID: PMC46349.
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Parkinson's disease. Fetal implants put to the test. Nature. 1993 Feb 04; 361(6411):405-6. Gage FH. PMID: 8429879.
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The neurotrophic hypothesis and the cholinergic basal forebrain projection. Prog Brain Res. 1993; 98:241-9. Lucidi-Phillipi CA, Gage FH. PMID: 8248513.
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Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal lesion. Hippocampus. 1993 Jan; 3(1):43-55. Shimohama S, Saitoh T, Gage FH. PMID: 8364682.
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Factors affecting proviral expression in primary cells grafted into the CNS. Res Publ Assoc Res Nerv Ment Dis. 1993; 71:311-23. Schinstine M, Gage FH. PMID: 8417470.
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Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's disease. Adv Neurol. 1993; 60:744-8. Shimohama S, Fisher LJ, Gage FH. PMID: 8093583.
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Gene transfer into established and primary fibroblast cell lines: comparison of transfection methods and promoters. Biotechniques. 1992 Oct; 13(4):598-603. Ray J, Gage FH. PMID: 1335735.
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Cytokine regulation of nerve growth factor-mediated cholinergic neurotrophic activity synthesized by astrocytes and fibroblasts. J Neurochem. 1992 Sep; 59(3):919-31. Yoshida K, Kakihana M, Chen LS, Ong M, Baird A, Gage FH. PMID: 1494917.
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Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats. J Neurosci. 1992 Jul; 12(7):2849-64. Kawaja MD, Rosenberg MB, Yoshida K, Gage FH. PMID: 1319481; PMCID: PMC6575835.
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Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts. J Neurochem. 1992 Jun; 58(6):2019-29. Schinstine M, Rosenberg MB, Routledge-Ward C, Friedmann T, Gage FH. PMID: 1573390.
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Quantitative effects of cerebral infarction on spatial learning in rats. Exp Neurol. 1992 May; 116(2):122-32. Lyden PD, Zivin JA, Chabolla DR, Jacobs MA, Gage FH. PMID: 1577120.
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Repopulating the mortal brain with immortal cells. Curr Biol. 1992 May; 2(5):232-4. Gage FH. PMID: 15335956.
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Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation. J Comp Neurol. 1992 Mar 01; 317(1):102-16. Kawaja MD, Gage FH. PMID: 1573056.
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Localization of hypoxanthine-guanine phosphoribosyltransferase mRNA in the mouse brain by in situ hybridization. Mol Cell Neurosci. 1992 Feb; 3(1):64-78. Jinnah HA, Hess EJ, Wilson MC, Gage FH, Friedmann T. PMID: 19912847.
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Neural transplants: prospects for Alzheimer's disease. Curr Opin Neurol Neurosurg. 1992 Feb; 5(1):94-9. Gage FH, Chen KS. PMID: 1352469.
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Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res. 1992 Jan 08; 569(1):14-25. Yoshida K, Gage FH. PMID: 1377078.
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Fetal brain tissue grafts modulate neuronal excitability in a chronic model of epilepsy. Epilepsy Res Suppl. 1992; 8:271-81. Buzsáki G, Gage FH. PMID: 1329819.
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Neurodegeneration and gene dysregulation: studies utilizing the mouse trisomy 16 model of Down syndrome. Prog Clin Biol Res. 1992; 379:227-44. Holtzman DM, Li Y, Gage FH, Epstein CJ, Mobley WC. PMID: 1409747.
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Delayed treatment with nerve growth factor improves acquisition of a spatial task in rats with lesions of the nucleus basalis magnocellularis: evaluation of the involvement of different neurotransmitter systems. Neuroscience. 1992; 48(1):111-9. Dekker AJ, Gage FH, Thal LJ. PMID: 1374860.
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Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol Aging. 1992 Jan-Feb; 13(1):9-23. Fischer W, Chen KS, Gage FH, Björklund A. PMID: 1311806.
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Effects of gene transfer into cultured CNS neurons with a replication-defective herpes simplex virus type 1 vector. Brain Res Mol Brain Res. 1992 Jan; 12(1-3):95-102. Johnson PA, Yoshida K, Gage FH, Friedmann T. PMID: 1312210.
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Development of the basal forebrain cholinergic system: phenotype expression prior to target innervation. Neurobiol Aging. 1992 Jan-Feb; 13(1):67-72. Thal LJ, Gilbertson E, Armstrong DM, Gage FH. PMID: 1542384.
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Physiological and behavioral consequences of delayed septal grafts in the subcortically denervated hippocampus. Restor Neurol Neurosci. 1992 Jan 01; 4(6):369-80. Buzsáki G, Hsu M, Horváth Z, Gage FH. PMID: 21551671.
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Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron. 1991 Dec; 7(6):1019-30. Kawaja MD, Gage FH. PMID: 1684900.
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Amphetamine-induced behavioral phenotype in a hypoxanthine-guanine phosphoribosyltransferase-deficient mouse model of Lesch-Nyhan syndrome. Behav Neurosci. 1991 Dec; 105(6):1004-12. Jinnah HA, Gage FH, Friedmann T. PMID: 1777100.
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Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann Neurol. 1991 Nov; 30(5):625-36. Tuszynski MH, Sang H, Yoshida K, Gage FH. PMID: 1763889.
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NGF increases cortical acetylcholine release in rats with lesions of the nucleus basalis. Neuroreport. 1991 Oct; 2(10):577-80. Dekker AJ, Langdon DJ, Gage FH, Thal LJ. PMID: 1756238.
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Intracerebral grafting in the dopaminergic system: issues and controversy. Curr Opin Neurobiol. 1991 Oct; 1(3):414-9. Gage FH, Kang UJ, Fisher LJ. PMID: 1821685.
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Genetically modified cells: applications for intracerebral grafting. Trends Neurosci. 1991 Aug; 14(8):328-33. Gage FH, Kawaja MD, Fisher LJ. PMID: 1721735.
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Hippocampal grafts into the intact brain induce epileptic patterns. Brain Res. 1991 Jul 19; 554(1-2):30-7. Buzsáki G, Masliah E, Chen LS, Horváth Z, Terry R, Gage FH. PMID: 1933310.
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Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior. Brain Res. 1991 Jul 12; 553(2):275-83. Carman LS, Gage FH, Shults CW. PMID: 1681983.
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NGF improves spatial memory in aged rodents as a function of age. J Neurosci. 1991 Jul; 11(7):1889-906. Fischer W, Björklund A, Chen K, Gage FH. PMID: 1648601; PMCID: PMC6575486.
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Intracerebral grafting of cultured autologous skin fibroblasts into the rat striatum: an assessment of graft size and ultrastructure. J Comp Neurol. 1991 May 22; 307(4):695-706. Kawaja MD, Fagan AM, Firestein BL, Gage FH. PMID: 1869637.
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Differential expression of protein kinase C isozymes in rat glial cell cultures. Brain Res. 1991 May 17; 549(1):106-11. Masliah E, Yoshida K, Shimohama S, Gage FH, Saitoh T. PMID: 1893244.
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Nerve growth factor receptor immunoreactivity in the rat septohippocampal pathway: a light and electron microscope investigation. J Comp Neurol. 1991 May 15; 307(3):517-29. Kawaja MD, Gage FH. PMID: 1649845.
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Emergence and propagation of interictal spikes in the subcortically denervated hippocampus. Hippocampus. 1991 Apr; 1(2):163-80. Buzsáki G, Hsu M, Slamka C, Gage FH, Horváth Z. PMID: 1669291.
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Cellular replacement therapy for neurologic disorders: potential of genetically engineered cells. J Cell Biochem. 1991 Mar; 45(3):252-7. Chen LS, Ray J, Fisher LJ, Kawaja MD, Schinstine M, Kang UJ, Gage FH. PMID: 2066374.
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Clinical improvement in parkinsonian patients undergoing adrenal to caudate transplantation is not reflected by chromogranin A or basic fibroblast growth factor in ventricular fluid. Exp Neurol. 1991 Mar; 111(3):276-81. Shults CW, O'Connor DT, Baird A, Hill R, Goetz CG, Watts RL, Klawans HL, Carvey PM, Bakay RA, Gage FH, et al. PMID: 1999231.
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Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron. 1991 Mar; 6(3):371-80. Fisher LJ, Jinnah HA, Kale LC, Higgins GA, Gage FH. PMID: 1672072.
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Functional recovery of supersensitive dopamine receptors after intrastriatal grafts of fetal substantia nigra. Exp Neurol. 1991 Mar; 111(3):282-92. Dawson TM, Dawson VL, Gage FH, Fisher LJ, Hunt MA, Wamsley JK. PMID: 1825638.
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Downregulation of muscarinic receptors in the rat caudate-putamen after lesioning of the ipsilateral nigrostriatal dopamine pathway with 6-hydroxydopamine (6-OHDA): normalization by fetal mesencephalic transplants. Brain Res. 1991 Feb 01; 540(1-2):145-52. Dawson TM, Dawson VL, Gage FH, Fisher LJ, Hunt MA, Wamsley JK. PMID: 1905173.
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Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res. 1991 Jan 04; 538(1):118-26. Yoshida K, Gage FH. PMID: 1708303.
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Reversal of nigrostriatal-lesion-induced receptor alterations by grafting of fetal mesencephalic dopaminergic neurons. Adv Exp Med Biol. 1991; 287:221-35. Wamsley JK, Dawson TM, Dawson VL, Hunt MA, Fisher LJ, Gage FH. PMID: 1759609.
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Intracerebral delivery of growth factors: potential application of genetically modified fibroblasts. Prog Growth Factor Res. 1991; 3(1):57-66. Schinstine M, Kawaja MD, Gage FH. PMID: 1777600.
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Basic FGF-SAP mitotoxin in the hippocampus. Specific lethal effect on cells expressing the basic FGF receptor. Ann N Y Acad Sci. 1991; 638:442-4. Gonzalez AM, Lappi DA, Buscaglia ML, Carman LS, Gage FH, Baird A. PMID: 1664696.
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Intracerebral grafting: a tool for the neurobiologist. Neuron. 1991 Jan; 6(1):1-12. Gage FH, Fisher LJ. PMID: 1986771.
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Employment of fibroblasts for gene transfer: applications for grafting into the central nervous system. Genet Eng (N Y). 1991; 13:205-20. Kawaja MD, Ray J, Gage FH. PMID: 1367415.
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Modeling cholinergic abnormalities in Down syndrome and Alzheimer's disease. Prog Clin Biol Res. 1991; 373:189-202. Holtzman DM, Li YW, Gage FH, DeArmond SJ, Epstein CJ, McKinley MP, Mobley WC. PMID: 1838184.
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In vivo assay of neuron-specific effects of nerve growth factor. Methods Enzymol. 1991; 198:35-48. Tuszynski MH, Gage FH. PMID: 1857228.
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Nerve growth factor function in the central nervous system. Curr Top Microbiol Immunol. 1991; 165:71-93. Gage FH, Tuszynski MH, Chen KS, Fagan AM, Higgins GA. PMID: 2032465.
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Electrophysiological characteristics of cells within mesencephalon suspension grafts. Neuroscience. 1991; 40(1):109-22. Fisher LJ, Young SJ, Tepper JM, Groves PM, Gage FH. PMID: 2052146.
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Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments. Brain Res. 1990 Dec 24; 537(1-2):123-30. Hellweg R, Fischer W, Hock C, Gage FH, Björklund A, Thoenen H. PMID: 2085767.
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Intracerebral grafting of genetically modified cells acting as biological pumps. Trends Pharmacol Sci. 1990 Nov; 11(11):437-9. Gage FH. PMID: 1980039.
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Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci. 1990 Nov; 10(11):3604-14. Tuszynski MH, U HS, Amaral DG, Gage FH. PMID: 2230949; PMCID: PMC6570113.
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Cholinergic sprouting in the hippocampus: a proposed role for IL-1. Exp Neurol. 1990 Oct; 110(1):105-20. Fagan AM, Gage FH. PMID: 1698653.
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Differential expression of protein kinase C isozymes in rat cerebellum. J Chem Neuroanat. 1990 Sep-Oct; 3(5):367-75. Shimohama S, Saitoh T, Gage FH. PMID: 2222892.
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Animal models of Lesch-Nyhan syndrome. Brain Res Bull. 1990 Sep; 25(3):467-75. Jinnah HA, Gage FH, Friedmann T. PMID: 2292045.
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Nucleus basalis lesions fail to induce senile plaques in the rat. Exp Neurol. 1990 Apr; 108(1):88-90. Thal LJ, Mandel RJ, Terry RD, Buzsaki G, Gage FH. PMID: 2318291.
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Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3032-6. Higgins GA, Oyler GA, Neve RL, Chen KS, Gage FH. PMID: 1970179; PMCID: PMC53828.
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Basal forebrain cell loss following fimbria/fornix transection. Brain Res. 1990 Feb 05; 508(2):241-8. Tuszynski MH, Armstrong DM, Gage FH. PMID: 2306615.
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Gene therapy in the CNS: intracerebral grafting of genetically modified cells. Prog Brain Res. 1990; 86:205-17. Gage FH, Rosenberg MB, Tuszynski MH, Yoshida K, Armstrong DM, Hayes RC, Friedmann T. PMID: 2087558.
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Adrenal chromaffin cells as multipotential neurons for autografts. Prog Brain Res. 1990; 82:33-9. Mahanthappa NK, Gage FH, Patterson PH. PMID: 2290947.
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Spatial organization of physiological activity in the hippocampal region: relevance to memory formation. Prog Brain Res. 1990; 83:257-68. Buzsáki G, Chen LS, Gage FH. PMID: 2203100.
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NGF-dependent sprouting and regeneration in the hippocampus. Prog Brain Res. 1990; 83:357-70. Gage FH, Buzsáki G, Armstrong DM. PMID: 2203102.
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Dopaminergic cells align along radial glia in the developing mesencephalon of the rat. Neuroscience. 1990; 38(2):427-36. Shults CW, Hashimoto R, Brady RM, Gage FH. PMID: 1979855.
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Grafting genetically modified cells to the brain: conceptual and technical issues. Prog Brain Res. 1990; 82:1-10. Gage FH, Fisher LJ, Jinnah HA, Rosenberg MB, Tuszynski MH, Friedmann T. PMID: 1981271.
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Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection. Neuroscience. 1990; 36(1):33-44. Tuszynski MH, Buzsaki G, Gage FH. PMID: 1699159.
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Restoration of function to the denervated spinal cord after implantation of embryonic 5HT- and substance P-containing raphe neurones. Prog Brain Res. 1990; 82:247-59. Foster GA, Brodin E, Gage FH, Maxwell DJ, Roberts MH, Sharp T. PMID: 1705354.
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Petit mal epilepsy and parkinsonian tremor: hypothesis of a common pacemaker. Neuroscience. 1990; 36(1):1-14. Buzsáki G, Smith A, Berger S, Fisher LJ, Gage FH. PMID: 2120612.
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Potential use of neurotrophic agents in the treatment of neurodegenerative disorders. Acta Neurobiol Exp (Wars). 1990; 50(4-5):311-22. Tuszynski MH, Gage FH. PMID: 2130651.
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Trophic regulation of basal forebrain gene expression in aging and Alzheimer's disease. Prog Brain Res. 1990; 86:239-55. Higgins GA, Koh S, Neve RL, Mufson EJ, Chen KS, Gage FH. PMID: 1965053.
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Autocrine differentiation of PC12 cells mediated by retroviral vectors. Dev Neurosci. 1990; 12(1):34-45. Short MP, Rosenberg MB, Ezzedine ZD, Gage FH, Friedmann T, Breakefield XO. PMID: 2105198.
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Extracellular properties of cells within mesencephalon suspension grafts in rat striatum. Prog Brain Res. 1990; 82:473-9. Fisher LJ, Young SJ, Groves PM, Gage FH. PMID: 2127113.
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Normalization of subtype-specific muscarinic receptor binding in the denervated hippocampus by septodiagonal band grafts. Exp Neurol. 1989 Nov; 106(2):115-24. Dawson VL, Gage FH, Hunt MA, Wamsley JK. PMID: 2806454.
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Role of neurotrophic factors in Alzheimer's disease. Neurobiol Aging. 1989 Sep-Oct; 10(5):545-6; discussion 552-3. Chen KS, Tuszynski MH, Gage FH. PMID: 2812224.
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Delivery of neuroactive compounds to the brain: potential utility of genetically modified cells. Neurobiol Aging. 1989 Sep-Oct; 10(5):644-5; discussion 648-50. Tuszynski MH, Jinnah HA, Gage FH. PMID: 2812247.
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NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat. Neuron. 1989 Aug; 3(2):247-56. Higgins GA, Koh S, Chen KS, Gage FH. PMID: 2560393.
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The grafted hippocampus: an epileptic focus. Exp Neurol. 1989 Jul; 105(1):10-22. Buzsáki G, Bayardo F, Miles R, Wong RK, Gage FH. PMID: 2744124.
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Age-related impairments in spatial memory are independent of those in sensorimotor skills. Neurobiol Aging. 1989 Jul-Aug; 10(4):347-52. Gage FH, Dunnett SB, Bjorklund A. PMID: 2682316.
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Nerve growth factor receptor and choline acetyltransferase colocalization in neurons within the rat forebrain: response to fimbria-fornix transection. J Comp Neurol. 1989 Jun 08; 284(2):187-204. Batchelor PE, Armstrong DM, Blaker SN, Gage FH. PMID: 2546981.
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Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase as a reporter gene. Brain Res Mol Brain Res. 1989 Jun; 5(4):271-8. Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T, Gage FH. PMID: 2501628.
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Spatial learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage. Exp Neurol. 1989 Jun; 104(3):208-17. Mandel RJ, Gage FH, Thal LJ. PMID: 2721623.
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Multisite recording of brain field potentials and unit activity in freely moving rats. J Neurosci Methods. 1989 Jun; 28(3):209-17. Buzsàki G, Bickford RG, Ryan LJ, Young S, Prohaska O, Mandel RJ, Gage FH. PMID: 2755179.
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Absence of long-term potentiation in the subcortically deafferented dentate gyrus. Brain Res. 1989 Apr 10; 484(1-2):94-101. Buzsáki G, Gage FH. PMID: 2713705.
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Potential use of nerve growth factor to treat Alzheimer's disease. Neurobiol Aging. 1989 Mar-Apr; 10(2):205-7. Phelps CH, Gage FH, Growdon JH, Hefti F, Harbaugh R, Johnston MV, Khachaturian ZS, Mobley WC, Price DL, Raskind M, et al. PMID: 2657468.
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NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum. Neuron. 1989 Feb; 2(2):1177-84. Gage FH, Batchelor P, Chen KS, Chin D, Higgins GA, Koh S, Deputy S, Rosenberg MB, Fischer W, Bjorklund A. PMID: 2576209.
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The cholinergic nucleus basalis: a key structure in neocortical arousal. EXS. 1989; 57:159-71. Buzsàki G, Gage FH. PMID: 2533089.
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Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen. Behav Brain Res. 1989 Jan 01; 31(3):221-9. Mandel RJ, Gage FH, Thal LJ. PMID: 2914073.
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Long-term potentiation of evoked and spontaneous neuronal activity in the grafted hippocampus. Exp Brain Res. 1989; 76(2):401-8. Buzsáki G, Wiesner J, Henriksen SJ, Gage FH. PMID: 2767191.
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Structural and functional analysis of raphe neurone implants into denervated rat spinal cord. Brain Res Bull. 1989 Jan; 22(1):131-7. Foster GA, Roberts MH, Wilkinson LS, Björklund A, Gage FH, Hökfelt T, Schultzberg M, Sharp T. PMID: 2713711.
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Intrahippocampal grafts of fetal basal forebrain tissue alter place fields in the hippocampus of rats with fimbria-fornix lesions. Neuroscience. 1989; 32(1):1-18. Shapiro ML, Simon DK, Olton DS, Gage FH, Nilsson O, Björklund A. PMID: 2586743.
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Neuronal activity in the subcortically denervated hippocampus: a chronic model for epilepsy. Neuroscience. 1989; 28(3):527-38. Buzsáki G, Ponomareff GL, Bayardo F, Ruiz R, Gage FH. PMID: 2710328.
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Survival, growth and function of damaged cholinergic neurons. EXS. 1989; 57:259-74. Gage FH, Tuszynski MH, Chen KS, Armstrong D, Buzsáki G. PMID: 2533097.
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Degenerative Changes in Forebrain Cholinergic Nuclei Correlate with Cognitive Impairments in Aged Rats. Eur J Neurosci. 1989 Jan; 1(1):34-45. Fischer W, Gage FH, Björklund A. PMID: 12106172.
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Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science. 1988 Dec 16; 242(4885):1575-8. Rosenberg MB, Friedmann T, Robertson RC, Tuszynski M, Wolff JA, Breakefield XO, Gage FH. PMID: 3201248.
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Suppression and induction of epileptic activity by neuronal grafts. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9327-30. Buzsáki G, Ponomareff G, Bayardo F, Shaw T, Gage FH. PMID: 3194427; PMCID: PMC282732.
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Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci. 1988 Nov; 8(11):4007-26. Buzsaki G, Bickford RG, Ponomareff G, Thal LJ, Mandel R, Gage FH. PMID: 3183710; PMCID: PMC6569493.
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Astrocytes are important for sprouting in the septohippocampal circuit. Exp Neurol. 1988 Oct; 102(1):2-13. Gage FH, Olejniczak P, Armstrong DM. PMID: 3181350.
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Electric activity in the neocortex of freely moving young and aged rats. Neuroscience. 1988 Sep; 26(3):735-44. Buzsáki G, Bickford RG, Armstrong DM, Ponomareff G, Chen KS, Ruiz R, Thal LJ, Gage FH. PMID: 3200427.
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Experimental approaches to age-related cognitive impairments. Neurobiol Aging. 1988 Sep-Dec; 9(5-6):645-55. Gage FH, Chen KS, Buzsaki G, Armstrong D. PMID: 3062473.
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Cholinergic neurons within the rat hippocampus: response to fimbria-fornix transection. J Comp Neurol. 1988 Jun 01; 272(1):127-38. Blaker SN, Armstrong DM, Gage FH. PMID: 3385020.
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Mechanisms of action of neural grafts in the limbic system. Can J Neurol Sci. 1988 May; 15(2):99-105. Buzsáki G, Gage FH. PMID: 3289709.
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Morphological response of axotomized septal neurons to nerve growth factor. J Comp Neurol. 1988 Mar 01; 269(1):147-55. Gage FH, Armstrong DM, Williams LR, Varon S. PMID: 3361001.
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Morphologic alterations of cholinergic processes in the neocortex of aged rats. Neurobiol Aging. 1988 Mar-Apr; 9(2):199-205. Armstrong DM, Hersh LB, Gage FH. PMID: 3374737.
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Restoration and deterioration of function by brain grafts in the septohippocampal system. Prog Brain Res. 1988; 78:69-77. Buzsáki G, Freund T, Björklund A, Gage FH. PMID: 3073427.
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Transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system. II. Grafts to the hippocampus. Exp Brain Res. 1988; 70(2):225-41. Foster GA, Schultzberg M, Gage FH, Björklund A, Hökfelt T, Cuello AC, Verhofstad AA, Visser TJ, Emson PC. PMID: 2454837.
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Transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system. III. Grafts to the striatum. Exp Brain Res. 1988; 70(2):242-55. Foster GA, Schultzberg M, Gage FH, Björklund A, Hökfelt T, Cuello AC, Verhofstad AA, Visser TJ, Emson PC. PMID: 2454838.
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Human amnion membrane matrix as a substratum for axonal regeneration in the central nervous system. Exp Brain Res. 1988; 72(2):371-80. Gage FH, Blaker SN, Davis GE, Engvall E, Varon S, Manthorpe M. PMID: 3224648.
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Intracerebral neuronal grafting in experimental animal models of age-related motor dysfunction. Ann N Y Acad Sci. 1988; 515:383-94. Gage FH, Brundin P, Strecker R, Dunnett SB, Isacson O, Bjorklund A. PMID: 3284426.
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Implantation of genetically engineered cells to the brain. Prog Brain Res. 1988; 78:651-8. Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. PMID: 2907815.
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Human amnion membrane as a substratum for axonal elongation in vitro and in vivo. Prog Brain Res. 1988; 78:435-8. Blaker SN, Davis GE, Manthorpe M, Engvall E, Varon S, Gage FH. PMID: 3073424.
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Intracerebral transplantation of dopamine neurons: understanding the functional role of the mesolimbocortical dopamine system and developing a therapy for Parkinson's disease. Ann N Y Acad Sci. 1988; 537:148-60. Brundin P, Strecker RE, Gage FH, Lindvall O, Björklund A. PMID: 3059921.
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Grafting genetically modified cells to the brain: possibilities for the future. Neuroscience. 1987 Dec; 23(3):795-807. Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee JK, Shults C, Friedmann T. PMID: 3325854.
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Development of cholinergic neurons in the septal/diagonal band complex of the rat. Brain Res. 1987 Dec 01; 433(2):249-56. Armstrong DM, Bruce G, Hersh LB, Gage FH. PMID: 3690335.
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Comparison of substance K-like and substance P-like fibers and cells in the rat hippocampus. Brain Res. 1987 Nov 24; 426(2):290-6. Shults CW, Johnston P, Gage FH. PMID: 2446709.
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Response of septal cholinergic neurons to axotomy. J Comp Neurol. 1987 Oct 15; 264(3):421-36. Armstrong DM, Terry RD, Deteresa RM, Bruce G, Hersh LB, Gage FH. PMID: 3680637.
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Cellular activity of intracerebrally transplanted fetal hippocampus during behavior. Neuroscience. 1987 Sep; 22(3):871-83. Buzsàki G, Czopf J, Kondàkor I, Björklund A, Gage FH. PMID: 3683854.
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Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature. 1987 Sep 3-9; 329(6134):65-8. Fischer W, Wictorin K, Björklund A, Williams LR, Varon S, Gage FH. PMID: 3627243.
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Neural grafting in a rat model of Huntington's disease: striosomal-like organization of striatal grafts as revealed by acetylcholinesterase histochemistry, immunocytochemistry and receptor autoradiography. Neuroscience. 1987 Aug; 22(2):481-97. Isacson O, Dawbarn D, Brundin P, Gage FH, Emson PC, Björklund A. PMID: 2823174.
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Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science. 1987 May 29; 236(4805):1106-9. Davis GE, Blaker SN, Engvall E, Varon S, Manthorpe M, Gage FH. PMID: 3576223.
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Loss of GABAergic neurons in medial septum after fimbria-fornix transection. Neurosci Lett. 1987 May 06; 76(2):140-4. Peterson GM, Williams LR, Varon S, Gage FH. PMID: 3035435.
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A small-gauge cannula device for continuous infusion of exogenous agents into the brain. Exp Neurol. 1987 Mar; 95(3):743-54. Williams LR, Vahlsing HL, Lindamood T, Varon S, Gage FH, Manthorpe M. PMID: 3545888.
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Behavioral dependence of the electrical activity of intracerebrally transplanted fetal hippocampus. Brain Res. 1987 Jan 06; 400(2):321-33. Buzsáki G, Gage FH, Kellényi L, Björklund A. PMID: 3815079.
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Restoration of rhythmic slow activity (theta) in the subcortically denervated hippocampus by fetal CNS transplants. Brain Res. 1987 Jan 06; 400(2):334-47. Buzsáki G, Gage FH, Czopf J, Björklund A. PMID: 3815080.
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Grafts of fetal septal cholinergic neurons to the hippocampal formation in aged or fimbria-fornix-lesioned rats. Ann N Y Acad Sci. 1987; 495:120-37. Björklund A, Gage FH. PMID: 3474938.
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Functional activity of raphe neurons transplanted to the hippocampus and caudate-putamen. An immunohistochemical and neurochemical analysis in adult and aged rats. Ann N Y Acad Sci. 1987; 495:169-84. Steinbusch HW, Beek A, Frankhuyzen AL, Tonnaer JA, Gage FH, Björklund A. PMID: 3474940.
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Synaptogenesis of grafted cholinergic neurons. Ann N Y Acad Sci. 1987; 495:268-83. Clarke DJ, Gage FH, Dunnett SB, Nilsson OG, Björklund A. PMID: 3474946.
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Denervation-induced enhancement of graft survival and growth. A trophic hypothesis. Ann N Y Acad Sci. 1987; 495:378-95. Gage FH, Björklund A. PMID: 3474951.
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Striatal neural transplants in the ibotenic acid-lesioned rat neostriatum. Cellular and functional aspects. Ann N Y Acad Sci. 1987; 495:537-55. Isacson O, Pritzel M, Dawbarn D, Brundin P, Kelly PA, Wiklund L, Emson PC, Gage FH, Dunnett SB, Björklund A. PMID: 3474959.
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Grafts of fetal septal cholinergic neurons to the hippocampal formation in aged or fimbria-fornix lesioned rats. Prog Brain Res. 1987; 72:333-42. Björklund A, Gage FH. PMID: 3615903.
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Spatial learning and memory following fimbria-fornix transection and grafting of fetal septal neurons to the hippocampus. Exp Brain Res. 1987; 67(1):195-215. Nilsson OG, Shapiro ML, Gage FH, Olton DS, Björklund A. PMID: 3622677.
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Grafts of fetal cholinergic neurons to the deafferented hippocampus. Prog Brain Res. 1987; 71:335-47. Gage FH, Buzsaki G, Nilsson O, Björklund A. PMID: 3588952.
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Exogenous administration of neuronotrophic factors in vivo protects central nervous system neurons against axotomy induced degeneration. Prog Brain Res. 1987; 71:191-201. Varon S, Williams LR, Gage FH. PMID: 3588942.
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Trophic and growth-regulating mechanisms in the central nervous system monitored by intracerebral neural transplants. Ciba Found Symp. 1987; 126:143-59. Gage FH, Björklund A. PMID: 3556083.
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Quantification of hippocampal noradrenaline and zinc changes after selective cell destruction. Exp Brain Res. 1987; 67(1):77-84. Kesslak JP, Frederickson CJ, Gage FH. PMID: 3622685.
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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci U S A. 1986 Dec; 83(23):9231-5. Williams LR, Varon S, Peterson GM, Wictorin K, Fischer W, Bjorklund A, Gage FH. PMID: 3466184; PMCID: PMC387109.
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Grafted septal neurons form cholinergic synaptic connections in the dentate gyrus of behaviorally impaired aged rats. J Comp Neurol. 1986 Oct 22; 252(4):483-92. Clarke DJ, Gage FH, Nilsson OG, Björklund A. PMID: 3782513.
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Cholinergic septal grafts into the hippocampal formation improve spatial learning and memory in aged rats by an atropine-sensitive mechanism. J Neurosci. 1986 Oct; 6(10):2837-47. Gage FH, Björklund A. PMID: 3760938; PMCID: PMC6568784.
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Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: quantitative temporal analysis. Neuroscience. 1986 Sep; 19(1):241-55. Gage FH, Wictorin K, Fischer W, Williams LR, Varon S, Bjorklund A. PMID: 3785665.
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Cell suspension grafts of noradrenergic locus coeruleus neurons in rat hippocampus and spinal cord: reinnervation and transmitter turnover. Neuroscience. 1986 Jul; 18(3):685-98. Björklund A, Nornes H, Gage FH. PMID: 2875418.
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Portacaval shunt in the rat: selective alterations in behavior and brain serotonin. Pharmacol Biochem Behav. 1986 Jun; 24(6):1611-6. Bengtsson F, Nobin A, Falck B, Gage FH, Jeppsson B. PMID: 2426719.
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Effects of confinement, previous experience and hippocampal damage on the DRL schedule. Behav Brain Res. 1986 May; 20(2):241-8. Acsádi G, Buzsáki G, Keszthelyi T, Királyfalvi L, Gage FH. PMID: 3730135.
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Recovery of spatial alternation deficits following selective hippocampal destruction with kainic acid. Behav Neurosci. 1986 Apr; 100(2):280-3. Kesslak JP, Gage FH. PMID: 3964429.
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Formation of cholinergic synapses by intrahippocampal septal grafts as revealed by choline acetyltransferase immunocytochemistry. Brain Res. 1986 Mar 26; 369(1-2):151-62. Clarke DJ, Gage FH, Björklund A. PMID: 3516309.
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The rotating 6-hydroxydopamine-lesioned mouse as a model for assessing functional effects of neuronal grafting. Brain Res. 1986 Feb 26; 366(1-2):346-9. Brundin P, Isacson O, Gage FH, Prochiantz A, Björklund A. PMID: 3084035.
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In vivo measurement of spontaneous release and metabolism of dopamine from intrastriatal nigral grafts using intracerebral dialysis. Brain Res. 1986 Jan 08; 362(2):344-9. Zetterström T, Brundin P, Gage FH, Sharp T, Isacson O, Dunnett SB, Ungerstedt U, Björklund A. PMID: 2417666.
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Transplantation of basal forebrain cholinergic neurons in the aged rat brain. Prog Brain Res. 1986; 70:499-512. Björklund A, Gage FH. PMID: 3554362.
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Intrastriatal grafting of dopamine-containing neuronal cell suspensions: effects of mixing with target or non-target cells. Brain Res. 1986 Jan; 389(1-2):77-84. Brundin P, Isacson O, Gage FH, Björklund A. PMID: 3081240.
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Neural grafting in the aged rat brain. Annu Rev Physiol. 1986; 48:447-59. Gage FH, Björklund A. PMID: 3010821.
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Short term status epilepticus in rats causes specific behavioral impairments related to substantia nigra necrosis. Exp Brain Res. 1986; 64(1):143-8. Lindvall O, Ingvar M, Gage FH. PMID: 3770107.
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Enhanced graft survival in the hippocampus following selective denervation. Neuroscience. 1986; 17(1):89-98. Gage FH, Björklund A. PMID: 3960317.
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Neural grafting in a rat model of Huntington's disease: progressive neurochemical changes after neostriatal ibotenate lesions and striatal tissue grafting. Neuroscience. 1985 Dec; 16(4):799-817. Isacson O, Brundin P, Gage FH, Björklund A. PMID: 2936982.
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Survival of intracerebrally grafted rat dopamine neurons previously cultured in vitro. Neurosci Lett. 1985 Oct 24; 61(1-2):79-84. Brundin P, Barbin G, Isacson O, Mallat M, Chamak B, Prochiantz A, Gage FH, Björklund A. PMID: 3935983.
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Brain monoamine metabolism and behavior in portacaval-shunted rats. Exp Neurol. 1985 Oct; 90(1):21-35. Bengtsson F, Gage FH, Jeppsson B, Nobin A, Rosengren E. PMID: 2412877.
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Rat fetal brain tissue grafts survive and innervate host brain following five day pregraft tissue storage. Neurosci Lett. 1985 Sep 30; 60(2):133-7. Gage FH, Brundin P, Isacson O, Björklund A. PMID: 4058805.
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Transplanted septal neurons make viable cholinergic synapses with a host hippocampus. Brain Res. 1985 Jun 17; 336(2):302-7. Segal M, Bjorklund A, Gage FH. PMID: 4005587.
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Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurol Res. 1985 Mar; 7(1):24-6. Wieloch T, Lindvall O, Blomqvist P, Gage FH. PMID: 2860584.
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Intracerebral neural grafting in animal models of aging brain: strategies, rationale and preliminary results. Dan Med Bull. 1985 Feb; 32 Suppl 1:35-9. Björklund A, Gage FH, Stenevi U, Dunnett SB, Kelly PA. PMID: 2859149.
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Transmitter expression and morphological development of embryonic medullary and mesencephalic raphé neurones after transplantation to the adult rat central nervous system. I. Grafts to the spinal cord. Exp Brain Res. 1985; 60(3):427-44. Foster GA, Schultzberg M, Gage FH, Björklund A, Hökfelt T, Nornes H, Cuello AC, Verhofstad AA, Visser TJ. PMID: 2416582.
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Functional reactivation of the deafferented hippocampus by embryonic septal grafts as assessed by measurements of local glucose utilization. Exp Brain Res. 1985; 58(3):570-9. Kelly PA, Gage FH, Ingvar M, Lindvall O, Stenevi U, Björklund A. PMID: 4007095.
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Neural grafting in animal models of neurodegenerative diseases. Ann N Y Acad Sci. 1985; 457:53-81. Björklund A, Gage FH. PMID: 3938191.
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Brain transplants: can they restore single unit activity in the hippocampus? Ann N Y Acad Sci. 1985; 444:536-7. Shapiro ML, Simon D, Olton DS, Gage FH, Bjorklund A, Stenevi U. PMID: 3860121.
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Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons. Exp Brain Res. 1985; 60(1):204-8. Brundin P, Nilsson OG, Gage FH, Björklund A. PMID: 3930278.
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Anatomical and functional consequences of grafting mesencephalic neurons into a peripheral nerve "bridge" connected to the denervated striatum. Exp Brain Res. 1985; 60(3):584-9. Gage FH, Stenevi U, Carlstedt T, Foster G, Björklund A, Aguayo AJ. PMID: 4076379.
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Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats. J Neurosci. 1984 Nov; 4(11):2856-65. Gage FH, Kelly PA, Björklund A. PMID: 6502208; PMCID: PMC6564735.
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Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum. Nature. 1984 Oct 4-10; 311(5985):458-60. Isacson O, Brundin P, Kelly PA, Gage FH, Björklund A. PMID: 6482962.
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Intrahippocampal septal grafts ameliorate learning impairments in aged rats. Science. 1984 Aug 03; 225(4661):533-6. Gage FH, Björklund A, Stenevi U, Dunnett SB, Kelly PA. PMID: 6539949.
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Dopamine-rich transplants in rats with 6-OHDA lesions of the ventral tegmental area. I. Effects on spontaneous and drug-induced locomotor activity. Behav Brain Res. 1984 Jul; 13(1):71-82. Dunnett SB, Bunch ST, Gage FH, Björklund A. PMID: 6477720.
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Denervation releases a neuronal survival factor in adult rat hippocampus. Nature. 1984 Apr 12-18; 308(5960):637-9. Gage FH, Björklund A, Stenevi U. PMID: 6424029.
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Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria-fornix transection. Neurosci Lett. 1984 Feb 10; 44(2):211-6. Gage FH, Björklund A, Stenevi U. PMID: 6709236.
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Functional significance of sympathohippocampal sprouting: changes in single cell spontaneous activity. Brain Res. 1984 Jan 23; 291(2):357-63. Barker DJ, Howard AJ, Gage FH. PMID: 6697196.
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Cholinergic denervation-induced increase of chelatable zinc in mossy-fiber region of the hippocampal formation. Brain Res. 1984 Jan 02; 290(1):43-51. Stewart GR, Frederickson CJ, Howell GA, Gage FH. PMID: 6692138.
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Spatial learning and motor deficits in aged rats. Neurobiol Aging. 1984; 5(1):43-8. Gage FH, Dunnett SB, Björklund A. PMID: 6738785.
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Intracerebral grafting of neuronal cell suspensions into the adult brain. Cent Nerv Syst Trauma. 1984; 1(1):47-56. Gage FH, Björklund A. PMID: 6400200.
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Hippocampal deafferentation: transplant-derived reinnervation and functional recovery. Acta Psychiatr Scand Suppl. 1984; 313:46-56. Dunnett SB, Gage FH, Björklund A, Stenevi U, Low WC, Iversen SD. PMID: 6322523.
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Local regulation of compensatory noradrenergic hyperactivity in the partially denervated hippocampus. Nature. 1983 Jun 30; 303(5920):819-21. Gage FH, Björklund A, Stenevi U. PMID: 6408481.
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Reinnervation of the partially deafferented hippocampus by compensatory collateral sprouting from spared cholinergic and noradrenergic afferents. Brain Res. 1983 May 23; 268(1):27-37. Gage FH, Björklund A, Stenevi U. PMID: 6860964.
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Functional correlates of compensatory collateral sprouting by aminergic and cholinergic afferents in the hippocampal formation. Brain Res. 1983 May 23; 268(1):39-47. Gage FH, Björklund A, Stenevi U, Dunnett SB. PMID: 6860965.
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Inhibition of synaptosomal neurotransmitter uptake by hallucinogens. J Neurochem. 1983 Apr; 40(4):1185-8. Whipple MR, Reinecke MG, Gage FH. PMID: 6131933.
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Intracerebral grafting of neuronal cell suspensions. III. Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiol Scand Suppl. 1983; 522:19-28. Schmidt RH, Björklund A, Stenevi U, Dunnett SB, Gage FH. PMID: 6326471.
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Pineal and habenula innervation altered by septal lesions. Brain Res Bull. 1983 Jan; 10(1):27-31. Chafetz MD, Gage FH. PMID: 6824964.
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Intracerebral grafting of embryonic neural cells into the adult host brain: an overview of the cell suspension method and its application. Dev Neurosci. 1983-1984; 6(3):137-51. Gage FH, Dunnett SB, Brundin P, Isacson O, Björklund A. PMID: 6389079.
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Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation. Acta Physiol Scand Suppl. 1983; 522:1-7. Björklund A, Stenevi U, Schmidt RH, Dunnett SB, Gage FH. PMID: 6586054.
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Intracerebral grafting of neuronal cell suspensions. VI. Survival and growth of intrahippocampal implants of septal cell suspensions. Acta Physiol Scand Suppl. 1983; 522:49-58. Björklund A, Gage FH, Stenevi U, Dunnett SB. PMID: 6586055.
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Intracerebral grafting of neuronal cell suspensions. VII. Recovery of choline acetyltransferase activity and acetylcholine synthesis in the denervated hippocampus reinnervated by septal suspension implants. Acta Physiol Scand Suppl. 1983; 522:59-66. Björklund A, Gage FH, Schmidt RH, Stenevi U, Dunnett SB. PMID: 6586056.
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Intracerebral grafting of neuronal cell suspensions. VIII. Survival and growth of implants of nigral and septal cell suspensions in intact brains of aged rats. Acta Physiol Scand Suppl. 1983; 522:67-75. Gage FH, Björklund A, Stenevi U, Dunnett SB. PMID: 6586057.
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Intracerebral grafting of neuronal cell suspensions. II. Survival and growth of nigral cell suspensions implanted in different brain sites. Acta Physiol Scand Suppl. 1983; 522:9-18. Björklund A, Stenevi U, Schmidt RH, Dunnett SB, Gage FH. PMID: 6586058.
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Fluorescence measurement of lesion-induced fiber growth. I. A microfluorometric technique to measure density and intensity of varicosities and fibers. Brain Res. 1982 Sep 16; 247(2):209-16. Chafetz MD, Gage FH. PMID: 6751469.
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Fluorescence measurement of lesion-induced fiber growth. II. Measurement of sympathohippocampal sprouting using a new microfluorometric method. Brain Res. 1982 Sep 16; 247(2):217-25. Chafetz MD, Evans S, Gage FH. PMID: 7127124.
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Cross-species neural grafting in a rat model of Parkinson's disease. Nature. 1982 Aug 12; 298(5875):652-4. Björklund A, Stenevi U, Dunnett SB, Gage FH. PMID: 7099260.
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Hippocampal deafferentation: transplant-derived reinnervation and functional recovery. Scand J Psychol. 1982; Suppl 1:104-11. Dunnett SB, Gage FH, Björklund A, Stenevi U, Low WC, Iversen SD. PMID: 6322287.
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Functional recovery following brain damage: conceptual frameworks and biological mechanisms. Scand J Psychol. 1982; Suppl 1:112-20. Gage FH, Dunnett SB, Björklund A, Stenevi U. PMID: 6142526.
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Reversible alterations in hypothalamic uptake of biogenic amines after septal lesions. Exp Neurol. 1981 Nov; 74(2):356-69. Thompson RG, Valdes JJ, Gage FH. PMID: 7297624.
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Biochemical specificity of septal hyperreactivity: a behavioral discrimination. Behav Brain Res. 1981 May; 2(3):409-20. Chafetz MD, Thompson RG, Evans SH, Gage FH. PMID: 6112009.
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Differential distribution of norepinephrine and serotonin along the dorsal-ventral axis of the hippocampal formation. Brain Res Bull. 1980 Nov-Dec; 5(6):771-3. Gage FH, Thompson RG. PMID: 7470947.
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Behavioral kinetics: a method for deriving qualitative and quantitative changes in sensory responsiveness following septal nuclei damage. Physiol Behav. 1980 Mar; 24(3):479-84. Gage FH, Armstrong DR, Thompson RG. PMID: 7375568.
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Endogenous norepinephrine and serotonin within the hippocampal formation during the development and recovery from septal hyperreactivity. Pharmacol Biochem Behav. 1978 Sep; 9(3):359-67. Gage FH, Thompson RG, Valdes JJ. PMID: 714984.
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Hippocampal connections and spatial discrimination. Brain Res. 1978 Jan 13; 139(2):295-308. Olton DS, Walker JA, Gage FH. PMID: 624061.
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Damage to hippocampus and hippocampal connections: effects on DRL and spontaneous alternation. J Comp Physiol Psychol. 1977 Jun; 91(3):508-22. Johnson CT, Olton DS, Gage FH, Jenko PG. PMID: 874119.
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Time-dependent fornix influence on increased light aversion induced by septal lesions. Physiol Behav. 1976 Oct; 17(4):607-14. Jenko PG, Gage FH, Olton DS. PMID: 1013210.
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Hippocampal influence on hyperreactivity induced by septal lesions. Brain Res. 1975 Nov 14; 98(2):311-25. Gage FH, Olton DS. PMID: 1182522.
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Role of the fornix in the septal syndrome. Physiol Behav. 1974 Aug; 13(2):269-79. Olton DS, Gage FH. PMID: 4415656.
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Changes in focal epileptic activity produced by brain-stem sections in the rabbit. Electroencephalogr Clin Neurophysiol. 1973 Nov; 35(5):475-86. Woodruff ML, Gage FH, Isaacson RL. PMID: 4126453.
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Hypothalamic stimulation and the persistence of epileptiform discharges. Brain Res. 1973 Jan 15; 49(1):194-9. Isaacson RL, Gage FH. PMID: 4698156.
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