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Integrated multiomics reveals inflammation-driven excessive erythrocytosis in subjects with Monge's disease. bioRxiv. 2025 Oct 21. Azad P, Caldwell AB, Villafuerte FC, Banihani S, Zhou D, Subramaniam S, Haddad GG. PMID: 41278713; PMCID: PMC12633210.
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Klinefelter syndrome: A neurodevelopmental disease of the synapse. Neurobiol Dis. 2025 09; 213:107010. Zhao H, Zhou D, Feng Y, Haddad GG. PMID: 40578768.
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Author Correction: Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Nat Commun. 2025 Feb 12; 16(1):1565. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sánchez-Sánchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araújo BMP, Velho PENF, Haddad GG, Muotri AR. PMID: 39939331; PMCID: PMC11822198.
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Time of sample collection is critical for the replicability of microbiome analyses. Nat Metab. 2024 Jul; 6(7):1282-1293. Allaband C, Lingaraju A, Flores Ramos S, Kumar T, Javaheri H, Tiu MD, Dantas Machado AC, Richter RA, Elijah E, Haddad GG, Leone VA, Dorrestein PC, Knight R, Zarrinpar A. PMID: 38951660; PMCID: PMC11309016.
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Investigating the neurobiology of maternal opioid use disorder and prenatal opioid exposure using brain organoid technology. Front Cell Neurosci. 2024; 18:1403326. Dwivedi I, Haddad GG. PMID: 38812788; PMCID: PMC11133580.
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Brain organoid protocols and limitations. Front Cell Neurosci. 2024; 18:1351734. Zhao HH, Haddad G. PMID: 38572070; PMCID: PMC10987830.
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The Pupa Stage Is the Most Sensitive to Hypoxia in Drosophila melanogaster. Int J Mol Sci. 2024 Jan 05; 25(2). Stobdan T, Wen NJ, Lu-Bo Y, Zhou D, Haddad GG. PMID: 38255782; PMCID: PMC10815303.
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A data-driven model for early prediction of need for invasive mechanical ventilation in pediatric intensive care unit patients. PLoS One. 2023; 18(8):e0289763. Bose SN, Defante A, Greenstein JL, Haddad GG, Ryu J, Winslow RL. PMID: 37540703; PMCID: PMC10403092.
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Buprenorphine and methadone differentially alter early brain development in human cortical organoids. Neuropharmacology. 2023 11 15; 239:109683. Yao H, Hu D, Wang J, Wu W, Zhao HH, Wang L, Gleeson J, Haddad GG. PMID: 37543137; PMCID: PMC11771310.
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Long noncoding RNA HIKER regulates erythropoiesis in Monge's disease via CSNK2B. J Clin Invest. 2023 06 01; 133(11). Azad P, Zhou D, Tu HC, Villafuerte FC, Traver D, Rana TM, Haddad GG. PMID: 37022795; PMCID: PMC10231995.
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Methadone alters transcriptional programs associated with synapse formation in human cortical organoids. Transl Psychiatry. 2023 05 06; 13(1):151. Dwivedi I, Caldwell AB, Zhou D, Wu W, Subramaniam S, Haddad GG. PMID: 37147277; PMCID: PMC10163238.
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Alzheimer's disease like neuropathology in Down syndrome cortical organoids. Front Cell Neurosci. 2022; 16:1050432. Zhao HH, Haddad GG. PMID: 36568886; PMCID: PMC9773144.
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Escherichia coli-Specific CXCL13-Producing TFH Are Associated with Clinical Efficacy of Neoadjuvant PD-1 Blockade against Muscle-Invasive Bladder Cancer. Cancer Discov. 2022 10 05; 12(10):2280-2307. Goubet AG, Lordello L, Alves Costa Silva C, Peguillet I, Gazzano M, Mbogning-Fonkou MD, Thelemaque C, Lebacle C, Thibault C, Audenet F, Pignot G, Gravis G, Helissey C, Campedel L, Roupret M, Xylinas E, Ouzaid I, Dubuisson A, Mazzenga M, Flament C, Ly P, Marty V, Signolle N, Sauvat A, Sbarrato T, Filahi M, Davin C, Haddad G, Bou Khalil J, Bleriot C, Danlos FX, Dunsmore G, Mulder K, Silvin A, Raoult T, Archambaud B, Belhechmi S, Gomperts Boneca I, Cayet N, Moya-Nilges M, Mallet A, Daillere R, Rouleau E, Radulescu C, Allory Y, Fieschi J, Rouanne M, Ginhoux F, Le Teuff G, Derosa L, Marabelle A, Van Dorp J, Van Dijk N, Van Der Heijden MS, Besse B, Andre F, Merad M, Kroemer G, Scoazec JY, Zitvogel L, Loriot Y. PMID: 35929803.
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A Boolean approach for novel hypoxia-related gene discovery. PLoS One. 2022; 17(8):e0273524. Stobdan T, Sahoo D, Haddad GG. PMID: 36006949; PMCID: PMC9409593.
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ARID1B, a molecular suppressor of erythropoiesis, is essential for the prevention of Monge's disease. Exp Mol Med. 2022 06; 54(6):777-787. Azad P, Caldwell AB, Ramachandran S, Spann NJ, Akbari A, Villafuerte FC, Bermudez D, Zhao H, Poulsen O, Zhou D, Bafna V, Subramaniam S, Haddad GG. PMID: 35672450; PMCID: PMC9256584.
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Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Nat Commun. 2022 05 02; 13(1):2387. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sánchez-Sánchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araújo BMP, Velho PENF, Haddad GG, Muotri AR. PMID: 35501322; PMCID: PMC9061776.
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Heterozygous Tropomodulin 3 mice have improved lung vascularization after chronic hypoxia. Hum Mol Genet. 2022 03 31; 31(7):1130-1140. Stobdan T, Jain PP, Xiong M, Bafna V, Yuan JX, Haddad GG. PMID: 34718575; PMCID: PMC8976430.
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SLC22 Transporters in the Fly Renal System Regulate Response to Oxidative Stress In Vivo. Int J Mol Sci. 2021 Dec 14; 22(24). Zhang P, Azad P, Engelhart DC, Haddad GG, Nigam SK. PMID: 34948211; PMCID: PMC8706193.
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Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2021 Dec 02; 108(12):2385. Ghosh SG, Becker K, Huang H, Salazar TD, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Weixler L, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. PMID: 34861176; PMCID: PMC8715173.
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Astrocytes propel neurovascular dysfunction during cerebral cavernous malformation lesion formation. J Clin Invest. 2021 07 01; 131(13). Lopez-Ramirez MA, Lai CC, Soliman SI, Hale P, Pham A, Estrada EJ, McCurdy S, Girard R, Verma R, Moore T, Lightle R, Hobson N, Shenkar R, Poulsen O, Haddad GG, Daneman R, Gongol B, Sun H, Lagarrigue F, Awad IA, Ginsberg MH. PMID: 34043589; PMCID: PMC8245174.
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Intermittent Hypoxia and Hypercapnia Alter Diurnal Rhythms of Luminal Gut Microbiome and Metabolome. mSystems. 2021 Jun 29; 6(3):101128msystems0011621. Allaband C, Lingaraju A, Martino C, Russell B, Tripathi A, Poulsen O, Dantas Machado AC, Zhou D, Xue J, Elijah E, Malhotra A, Dorrestein PC, Knight R, Haddad GG, Zarrinpar A. PMID: 34184915; PMCID: PMC8269208.
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Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy. Mol Psychiatry. 2021 11; 26(11):7047-7068. Negraes PD, Trujillo CA, Yu NK, Wu W, Yao H, Liang N, Lautz JD, Kwok E, McClatchy D, Diedrich J, de Bartolome SM, Truong J, Szeto R, Tran T, Herai RH, Smith SEP, Haddad GG, Yates JR, Muotri AR. PMID: 33888873; PMCID: PMC8531162.
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Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome. Front Physiol. 2021; 12:663950. Xue J, Allaband C, Zhou D, Poulsen O, Martino C, Jiang L, Tripathi A, Elijah E, Dorrestein PC, Knight R, Zarrinpar A, Haddad GG. PMID: 33897472; PMCID: PMC8060652.
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Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster. Nat Commun. 2021 02 12; 12(1):997. Iranmehr A, Stobdan T, Zhou D, Zhao H, Kryazhimskiy S, Bafna V, Haddad GG. PMID: 33579965; PMCID: PMC7881140.
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Genetic interactions regulate hypoxia tolerance conferred by activating Notch in excitatory amino acid transporter 1-positive glial cells in Drosophila melanogaster. G3 (Bethesda). 2021 02 09; 11(2). Zhou D, Stobdan T, Visk D, Xue J, Haddad GG. PMID: 33576765; PMCID: PMC8022968.
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Protective role of estrogen against excessive erythrocytosis in Monge's disease. Exp Mol Med. 2021 01; 53(1):125-135. Azad P, Villafuerte FC, Bermudez D, Patel G, Haddad GG. PMID: 33473144; PMCID: PMC8080600.
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Neuroprotective Role of Akt in Hypoxia Adaptation in Andeans. Front Neurosci. 2020; 14:607711. Zhao H, Lin J, Sieck G, Haddad GG. PMID: 33519361; PMCID: PMC7843528.
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Running after ghosts: are dead bacteria the dark matter of the human gut microbiota? Gut Microbes. 2021 Jan-Dec; 13(1):1-12. Bellali S, Lagier JC, Million M, Anani H, Haddad G, Francis R, Kuete Yimagou E, Khelaifia S, Levasseur A, Raoult D, Bou Khalil J. PMID: 33757378; PMCID: PMC7993147.
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Methadone Suppresses Neuronal Function and Maturation in Human Cortical Organoids. Front Neurosci. 2020; 14:593248. Wu W, Yao H, Dwivedi I, Negraes PD, Zhao HW, Wang J, Trujillo CA, Muotri AR, Haddad GG. PMID: 33328864; PMCID: PMC7719724.
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Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Int J Mol Sci. 2020 Mar 15; 21(6). Engelhart DC, Azad P, Ali S, Granados JC, Haddad GG, Nigam SK. PMID: 32183456; PMCID: PMC7139749.
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Global chemical effects of the microbiome include new bile-acid conjugations. Nature. 2020 03; 579(7797):123-129. Quinn RA, Melnik AV, Vrbanac A, Fu T, Patras KA, Christy MP, Bodai Z, Belda-Ferre P, Tripathi A, Chung LK, Downes M, Welch RD, Quinn M, Humphrey G, Panitchpakdi M, Weldon KC, Aksenov A, da Silva R, Avila-Pacheco J, Clish C, Bae S, Mallick H, Franzosa EA, Lloyd-Price J, Bussell R, Thron T, Nelson AT, Wang M, Leszczynski E, Vargas F, Gauglitz JM, Meehan MJ, Gentry E, Arthur TD, Komor AC, Poulsen O, Boland BS, Chang JT, Sandborn WJ, Lim M, Garg N, Lumeng JC, Xavier RJ, Kazmierczak BI, Jain R, Egan M, Rhee KE, Ferguson D, Raffatellu M, Vlamakis H, Haddad GG, Siegel D, Huttenhower C, Mazmanian SK, Evans RM, Nizet V, Knight R, Dorrestein PC. PMID: 32103176; PMCID: PMC7252668.
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Intermittent hypoxia and hypercapnia induces inhibitor of nuclear factor-κB kinase subunit β-dependent atherosclerosis in pulmonary arteries. Am J Physiol Regul Integr Comp Physiol. 2019 12 01; 317(6):R763-R769. Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. PMID: 31618063; PMCID: PMC6962627.
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Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with chronic mountain sickness. Am J Physiol Regul Integr Comp Physiol. 2020 01 01; 318(1):R49-R56. Bermudez D, Azad P, Figueroa-Mujíca R, Vizcardo-Galindo G, Corante N, Guerra-Giraldez C, Haddad GG, Villafuerte FC. PMID: 31617751; PMCID: PMC6985794.
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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development. Cell Stem Cell. 2019 10 03; 25(4):558-569.e7. Trujillo CA, Gao R, Negraes PD, Gu J, Buchanan J, Preissl S, Wang A, Wu W, Haddad GG, Chaim IA, Domissy A, Vandenberghe M, Devor A, Yeo GW, Voytek B, Muotri AR. PMID: 31474560; PMCID: PMC6778040.
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Intermittent Hypoxia and Hypercapnia Reproducibly Change the Gut Microbiome and Metabolome across Rodent Model Systems. mSystems. 2019 Mar-Apr; 4(2). Tripathi A, Xu ZZ, Xue J, Poulsen O, Gonzalez A, Humphrey G, Meehan MJ, Melnik AV, Ackermann G, Zhou D, Malhotra A, Haddad GG, Dorrestein PC, Knight R. PMID: 31058230; PMCID: PMC6495231.
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Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders. J Lung Health Dis. 2019; 3(2):29-30. Stobdan T, Haddad GG. PMID: 31304480; PMCID: PMC6625522.
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High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. PLoS One. 2019; 14(3):e0213474. Stobdan T, Sahoo D, Azad P, Hartley I, Heinrichsen E, Zhou D, Haddad GG. PMID: 30861021; PMCID: PMC6413938.
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Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 11 01; 103(5):826. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. PMID: 30388405; PMCID: PMC6218605.
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Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders. Eur J Hum Genet. 2019 01; 27(1):150-159. Iranmehr A, Stobdan T, Zhou D, Poulsen O, Strohl KP, Aldashev A, Telenti A, Wong EHM, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 30254217; PMCID: PMC6303266.
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Biallelic Mutations in ADPRHL2, Encoding ADP-Ribosylhydrolase 3, Lead to a Degenerative Pediatric Stress-Induced Epileptic Ataxia Syndrome. Am J Hum Genet. 2018 09 06; 103(3):431-439. Ghosh SG, Becker K, Huang H, Dixon-Salazar T, Chai G, Salpietro V, Al-Gazali L, Waisfisz Q, Wang H, Vaux KK, Stanley V, Manole A, Akpulat U, Weiss MM, Efthymiou S, Hanna MG, Minetti C, Striano P, Pisciotta L, De Grandis E, Altmüller J, Nürnberg P, Thiele H, Yis U, Okur TD, Polat AI, Amiri N, Doosti M, Karimani EG, Toosi MB, Haddad G, Karakaya M, Wirth B, van Hagen JM, Wolf NI, Maroofian R, Houlden H, Cirak S, Gleeson JG. PMID: 30100084; PMCID: PMC6128219.
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Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia. J Mol Med (Berl). 2018 09; 96(9):975-982. Stobdan T, Zhou D, Williams AT, Cabrales P, Haddad GG. PMID: 30069745; PMCID: PMC6374051.
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Exploring miRNA-mRNA regulatory network in cardiac pathology in Na+/H+ exchanger isoform 1 transgenic mice. Physiol Genomics. 2018 10 01; 50(10):846-861. Xue J, Zhou D, Poulsen O, Hartley I, Imamura T, Xie EX, Haddad GG. PMID: 30029588; PMCID: PMC6230871.
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Intermittent Hypoxia and Hypercapnia, a Hallmark of Obstructive Sleep Apnea, Alters the Gut Microbiome and Metabolome. mSystems. 2018 May-Jun; 3(3). Tripathi A, Melnik AV, Xue J, Poulsen O, Meehan MJ, Humphrey G, Jiang L, Ackermann G, McDonald D, Zhou D, Knight R, Dorrestein PC, Haddad GG. PMID: 29896566; PMCID: PMC5989129.
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Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness. Neuroscience. 2018 04 01; 375:25-33. Yao H, Zhao H, Wang J, Haddad GG. PMID: 29438800; PMCID: PMC5851838.
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Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge's Disease. Neuroscience. 2018 03 15; 374:70-79. Wu W, Yao H, Zhao HW, Wang J, Haddad GG. PMID: 29355592.
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Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness. J Appl Physiol (1985). 2018 09 01; 125(3):832-840. Zhao H, Perkins G, Yao H, Callacondo D, Appenzeller O, Ellisman M, La Spada AR, Haddad GG. PMID: 29357502; PMCID: PMC6734077.
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New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Mol Biol Evol. 2017 Dec 01; 34(12):3154-3168. Stobdan T, Akbari A, Azad P, Zhou D, Poulsen O, Appenzeller O, Gonzales GF, Telenti A, Wong EHM, Saini S, Kirkness EF, Venter JC, Bafna V, Haddad GG. PMID: 29029226; PMCID: PMC5850797.
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Intermittent Hypoxia and Hypercapnia Accelerate Atherosclerosis, Partially via Trimethylamine-Oxide. Am J Respir Cell Mol Biol. 2017 11; 57(5):581-588. Xue J, Zhou D, Poulsen O, Imamura T, Hsiao YH, Smith TH, Malhotra A, Dorrestein P, Knight R, Haddad GG. PMID: 28678519; PMCID: PMC5705907.
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High-altitude adaptation in humans: from genomics to integrative physiology. J Mol Med (Berl). 2017 Dec; 95(12):1269-1282. Azad P, Stobdan T, Zhou D, Hartley I, Akbari A, Bafna V, Haddad GG. PMID: 28951950; PMCID: PMC8936998.
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Transcriptomic analysis identifies a role of PI3K-Akt signalling in the responses of skeletal muscle to acute hypoxia in vivo. J Physiol. 2017 09 01; 595(17):5797-5813. Gan Z, Powell FL, Zambon AC, Buchholz KS, Fu Z, Ocorr K, Bodmer R, Moya EA, Stowe JC, Haddad GG, McCulloch AD. PMID: 28688178; PMCID: PMC5577531.
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Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease. J Exp Med. 2016 11 14; 213(12):2729-2744. Azad P, Zhao HW, Cabrales PJ, Ronen R, Zhou D, Poulsen O, Appenzeller O, Hsiao YH, Bafna V, Haddad GG. PMID: 27821551; PMCID: PMC5110013.
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The Na+/HCO3- co-transporter is protective during ischemia in astrocytes. Neuroscience. 2016 Dec 17; 339:329-337. Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG. PMID: 27717805; PMCID: PMC5118130.
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Intermittent hypoxia induces murine macrophage foam cell formation by IKK-β-dependent NF-κB pathway activation. J Appl Physiol (1985). 2016 09 01; 121(3):670-7. Imamura T, Poulsen O, Haddad GG. PMID: 27471237; PMCID: PMC5142255.
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Experimental evolution of recombination and crossover interference in Drosophila caused by directional selection for stress-related traits. BMC Biol. 2015 Nov 27; 13:101. Aggarwal DD, Rashkovetsky E, Michalak P, Cohen I, Ronin Y, Zhou D, Haddad GG, Korol AB. PMID: 26614097; PMCID: PMC4661966.
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Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Mol Biol Evol. 2016 Feb; 33(2):501-17. Jha AR, Zhou D, Brown CD, Kreitman M, Haddad GG, White KP. PMID: 26576852; PMCID: PMC4866538.
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Cardiac responses to hypoxia and reoxygenation in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2015 Dec 01; 309(11):R1347-57. Zarndt R, Piloto S, Powell FL, Haddad GG, Bodmer R, Ocorr K. PMID: 26377557; PMCID: PMC4698404.
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Notch Activation of Ca(2+) Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):355-67. Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX. PMID: 25569851; PMCID: PMC4566064.
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Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10425-30. Stobdan T, Zhou D, Ao-Ieong E, Ortiz D, Ronen R, Hartley I, Gan Z, McCulloch AD, Bafna V, Cabrales P, Haddad GG. PMID: 26240367; PMCID: PMC4547246.
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Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda). 2015 Apr 03; 5(6):1107-16. Manchenkov T, Pasillas MP, Haddad GG, Imam FB. PMID: 25840431; PMCID: PMC4478541.
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Altered iPSC-derived neurons' sodium channel properties in subjects with Monge's disease. Neuroscience. 2015 Mar 12; 288:187-99. Zhao HW, Gu XQ, Chailangkarn T, Perkins G, Callacondo D, Appenzeller O, Poulsen O, Zhou D, Muotri AR, Haddad GG. PMID: 25559931; PMCID: PMC4323892.
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High-throughput cell death assays. Methods Mol Biol. 2015; 1254:153-63. Pamenter ME, Haddad GG. PMID: 25431064.
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A Drosophila ABC transporter regulates lifespan. PLoS Genet. 2014 Dec; 10(12):e1004844. Huang H, Lu-Bo Y, Haddad GG. PMID: 25474322; PMCID: PMC4256198.
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Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons. Mol Psychiatry. 2015 Nov; 20(11):1350-65. Griesi-Oliveira K, Acab A, Gupta AR, Sunaga DY, Chailangkarn T, Nicol X, Nunez Y, Walker MF, Murdoch JD, Sanders SJ, Fernandez TV, Ji W, Lifton RP, Vadasz E, Dietrich A, Pradhan D, Song H, Ming GL, Gu X, Haddad G, Marchetto MC, Spitzer N, Passos-Bueno MR, State MW, Muotri AR. PMID: 25385366; PMCID: PMC4427554.
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The genetic basis of chronic mountain sickness. Physiology (Bethesda). 2014 Nov; 29(6):403-12. Ronen R, Zhou D, Bafna V, Haddad GG. PMID: 25362634; PMCID: PMC4280153.
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Wnt pathway activation increases hypoxia tolerance during development. PLoS One. 2014; 9(8):e103292. Gersten M, Zhou D, Azad P, Haddad GG, Subramaniam S. PMID: 25093834; PMCID: PMC4122365.
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Fine tuning of the UPR by the ubiquitin ligases Siah1/2. PLoS Genet. 2014 May; 10(5):e1004348. Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. PMID: 24809345; PMCID: PMC4014425.
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MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data. BMC Bioinformatics. 2014 Mar 12; 15:69. Gan Z, Wang J, Salomonis N, Stowe JC, Haddad GG, McCulloch AD, Altintas I, Zambon AC. PMID: 24621103; PMCID: PMC3975178.
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Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes. Genome Biol. 2014 Feb 20; 15(2):R36. Udpa N, Ronen R, Zhou D, Liang J, Stobdan T, Appenzeller O, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Claydon VE, Hainsworth R, Gamboa JL, Zibenigus M, Zenebe G, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. PMID: 24555826; PMCID: PMC4054780.
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Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma. Glia. 2014 Apr; 62(4):504-13. Gu XQ, Pamenter ME, Siemen D, Sun X, Haddad GG. PMID: 24446243.
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Do BK channels mediate glioma hypoxia-tolerance? Channels (Austin). 2014; 8(3):176-7. Pamenter ME, Haddad GG. PMID: 24813649; PMCID: PMC5210165.
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Hematopoietic stem cells: potential new applications for translational medicine. J Stem Cells. 2014; 9(3):163-97. Felfly H, Haddad GG. PMID: 25157450.
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Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures. PLoS One. 2013; 8(10):e77859. Hartley I, Elkhoury FF, Heon Shin J, Xie B, Gu X, Gao Y, Zhou D, Haddad GG. PMID: 24205000; PMCID: PMC3808424.
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Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster. Mol Metab. 2014 Feb; 3(1):42-54. Heinrichsen ET, Zhang H, Robinson JE, Ngo J, Diop S, Bodmer R, Joiner WJ, Metallo CM, Haddad GG. PMID: 24567903; PMCID: PMC3929909.
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Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions. PLoS One. 2013; 8(9):e74011. Yin S, Xue J, Sun H, Wen B, Wang Q, Perkins G, Zhao HW, Ellisman MH, Hsiao YH, Yin L, Xie Y, Hou G, Zi J, Lin L, Haddad GG, Zhou D, Liu S. PMID: 24069262; PMCID: PMC3771901.
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Intermittent hypoxia and hypercapnia induce pulmonary artery atherosclerosis and ventricular dysfunction in low density lipoprotein receptor deficient mice. J Appl Physiol (1985). 2013 Dec; 115(11):1694-704. Douglas RM, Bowden K, Pattison J, Peterson AB, Juliano J, Dalton ND, Gu Y, Alvarez E, Imamura T, Peterson KL, Witztum JL, Haddad GG, Li AC. PMID: 23990245; PMCID: PMC3882740.
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Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders. Am J Hum Genet. 2013 Sep 05; 93(3):452-62. Zhou D, Udpa N, Ronen R, Stobdan T, Liang J, Appenzeller O, Zhao HW, Yin Y, Du Y, Guo L, Cao R, Wang Y, Jin X, Huang C, Jia W, Cao D, Guo G, Gamboa JL, Villafuerte F, Callacondo D, Xue J, Liu S, Frazer KA, Li Y, Bafna V, Haddad GG. PMID: 23954164; PMCID: PMC3769925.
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Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Annu Rev Genomics Hum Genet. 2013; 14:25-43. Zhou D, Haddad GG. PMID: 23808366; PMCID: PMC12990993.
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Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia. BMC Genomics. 2013; 14 Suppl 3:S9. Xie L, Ng C, Ali T, Valencia R, Ferreira BL, Xue V, Tanweer M, Zhou D, Haddad GG, Bourne PE, Xie L. PMID: 23819581; PMCID: PMC3665574.
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DIDS (4,4-diisothiocyanatostilbenedisulphonic acid) induces apoptotic cell death in a hippocampal neuronal cell line and is not neuroprotective against ischemic stress. PLoS One. 2013; 8(4):e60804. Pamenter ME, Perkins GA, Gu XQ, Ellisman MH, Haddad GG. PMID: 23577164; PMCID: PMC3618322.
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Physiology's impact: discovering life. Physiology (Bethesda). 2013 Mar; 28(2):62-3. Sieck GC, Haddad GG, Lucchesi P. PMID: 23455765; PMCID: PMC3768088.
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Chemokine receptor-like 2 is involved in ischemic brain injury. J Exp Stroke Transl Med. 2013 Feb 17; 6:1-6. Douglas RM, Chen AH, Iniguez A, Wang J, Fu Z, Powell FL, Haddad GG, Yao H. PMID: 23847708; PMCID: PMC3705577.
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Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One. 2012; 7(12):e51469. Pamenter ME, Perkins GA, McGinness AK, Gu XQ, Ellisman MH, Haddad GG. PMID: 23251543; PMCID: PMC3520810.
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Genetic animal models of preconditioning. Transl Stroke Res. 2013 Feb; 4(1):51-5. Azad P, Haddad GG. PMID: 23565128; PMCID: PMC3614364.
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Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. G3 (Bethesda). 2012 Oct; 2(10):1169-78. Azad P, Zhou D, Zarndt R, Haddad GG. PMID: 23050227; PMCID: PMC3464109.
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Clinical effectiveness and safety of permissive hypercapnia. Clin Perinatol. 2012 Sep; 39(3):603-12. Ryu J, Haddad G, Carlo WA. PMID: 22954272.
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Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous. Forensic Sci Med Pathol. 2012 Dec; 8(4):414-25. Kinney HC, Rognum TO, Nattie EE, Haddad GG, Hyma B, McEntire B, Paterson DS, Crandall L, Byard RW. PMID: 22941540.
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DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release. PLoS One. 2012; 7(8):e43995. Pamenter ME, Ryu J, Hua ST, Perkins GA, Mendiola VL, Gu XQ, Ellisman MH, Haddad GG. PMID: 22937143; PMCID: PMC3427179.
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Role of high-fat diet in stress response of Drosophila. PLoS One. 2012; 7(8):e42587. Heinrichsen ET, Haddad GG. PMID: 22870336; PMCID: PMC3411628.
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Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra. J Cereb Blood Flow Metab. 2012 Nov; 32(11):2033-43. Pamenter ME, Hogg DW, Gu XQ, Buck LT, Haddad GG. PMID: 22805876; PMCID: PMC3493991.
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The utility of a portable recording device for screening of obstructive sleep apnea in obese adolescents. J Clin Sleep Med. 2012 Jun 15; 8(3):271-7. Lesser DJ, Haddad GG, Bush RA, Pian MS. PMID: 22701384; PMCID: PMC3365085.
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Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage. PLoS One. 2012; 7(5):e36801. Ali SS, Hsiao M, Zhao HW, Dugan LL, Haddad GG, Zhou D. PMID: 22574227; PMCID: PMC3344937.
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An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons. Brain Res. 2012 May 03; 1452:165-72. Pamenter ME, Ali SS, Tang Q, Finley JC, Gu XQ, Dugan LL, Haddad GG. PMID: 22459046; PMCID: PMC3326196.
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Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production? Antioxid Redox Signal. 2012 May 15; 16(10):1071-6. Zhao HW, Ali SS, Haddad GG. PMID: 22229946; PMCID: PMC3315163.
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Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species. Free Radic Biol Med. 2012 Mar 15; 52(6):1033-42. Mittal M, Gu XQ, Pak O, Pamenter ME, Haag D, Fuchs DB, Schermuly RT, Ghofrani HA, Brandes RP, Seeger W, Grimminger F, Haddad GG, Weissmann N. PMID: 22222468.
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Tests of selection in pooled case-control data: an empirical study. Front Genet. 2011; 2:83. Udpa N, Zhou D, Haddad GG, Bafna V. PMID: 22303377; PMCID: PMC3268381.
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Does the brain gain back energy during sleep? But what does it mean? Sleep. 2011 Jul 01; 34(7):835-6. Haddad GG. PMID: 21731130; PMCID: PMC3119555.
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Identification of a neuronal gene expression signature: role of cell cycle arrest in murine neuronal differentiation in vitro. Am J Physiol Regul Integr Comp Physiol. 2011 Sep; 301(3):R727-45. Felfly H, Xue J, Zambon AC, Muotri A, Zhou D, Haddad GG. PMID: 21677276; PMCID: PMC3174756.
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Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia. Free Radic Biol Med. 2011 Jul 15; 51(2):530-8. Azad P, Ryu J, Haddad GG. PMID: 21616137; PMCID: PMC3138732.
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Review: Hypoxic and oxidative stress resistance in Drosophila melanogaster. Placenta. 2011 Mar; 32 Suppl 2:S104-8. Zhao HW, Haddad GG. PMID: 21353099; PMCID: PMC3073591.
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Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2349-54. Zhou D, Udpa N, Gersten M, Visk DW, Bashir A, Xue J, Frazer KA, Posakony JW, Subramaniam S, Bafna V, Haddad GG. PMID: 21262834; PMCID: PMC3038716.
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Severe Hypoxia: Consequences to Neural Stem Cells and Neurons. J Neurol Res. 2011; 1(5). Felfly H, Zambon AC, Xue J, Muotri A, Zhou D, Snyder EY, Haddad GG. PMID: 24348887; PMCID: PMC3858017.
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Effects of oxygen on growth and size: synthesis of molecular, organismal, and evolutionary studies with Drosophila melanogaster. Annu Rev Physiol. 2011; 73:95-113. Harrison JF, Haddad GG. PMID: 20936942.
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Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem. 2011 Feb 25; 286(8):6211-8. Zhao HW, Zhou D, Haddad GG. PMID: 21148307; PMCID: PMC3057857.
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Experimental selection for Drosophila survival in extremely high O2 environments. PLoS One. 2010 Jul 23; 5(7):e11701. Zhao HW, Zhou D, Nizet V, Haddad GG. PMID: 20668515; PMCID: PMC2909141.
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Hematopoietic stem cell transplantation protects mice from lethal stroke. Exp Neurol. 2010 Oct; 225(2):284-93. Felfly H, Muotri A, Yao H, Haddad GG. PMID: 20547154; PMCID: PMC2963425.
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Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy. Physiol Genomics. 2010 Aug; 42(3):374-83. Xue J, Mraiche F, Zhou D, Karmazyn M, Oka T, Fliegel L, Haddad GG. PMID: 20460605; PMCID: PMC2929882.
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The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010 May 05; 11(5):364-78. Zhang N, Fu Z, Linke S, Chicher J, Gorman JJ, Visk D, Haddad GG, Poellinger L, Peet DJ, Powell F, Johnson RS. PMID: 20399150; PMCID: PMC2893150.
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Chronic hypercapnia alters lung matrix composition in mouse pups. J Appl Physiol (1985). 2010 Jul; 109(1):203-10. Ryu J, Heldt GP, Nguyen M, Gavrialov O, Haddad GG. PMID: 20360436; PMCID: PMC2904197.
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Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1594-602. Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS. PMID: 20357179; PMCID: PMC2889641.
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Heart rhythm genomic fabric in hypoxia. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1769-74. Iacobas DA, Iacobas S, Haddad GG. PMID: 20044980; PMCID: PMC2849310.
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Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures. J Neurochem. 2010 Jan; 112(2):377-88. Sun X, Yao H, Douglas RM, Gu XQ, Wang J, Haddad GG. PMID: 19860861; PMCID: PMC4524356.
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Epidermal growth factor receptor translocation to the mitochondria: regulation and effect. J Biol Chem. 2009 Dec 25; 284(52):36592-36604. Demory ML, Boerner JL, Davidson R, Faust W, Miyake T, Lee I, Hüttemann M, Douglas R, Haddad G, Parsons SJ. PMID: 19840943; PMCID: PMC2794774.
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Survival in acute and severe low o environment: use of a genetic model system. Ann N Y Acad Sci. 2009 Oct; 1177:39-47. Azad P, Haddad GG. PMID: 19845605.
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Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis. BMC Syst Biol. 2009 Sep 09; 3:91. Feala JD, Coquin L, Zhou D, Haddad GG, Paternostro G, McCulloch AD. PMID: 19740440; PMCID: PMC2749811.
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Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia. Pediatr Res. 2009 Sep; 66(3):239-47. Zhou D, Visk DW, Haddad GG. PMID: 19542900; PMCID: PMC6620046.
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Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8760-5. Guma M, Rius J, Duong-Polk KX, Haddad GG, Lindsey JD, Karin M. PMID: 19433784; PMCID: PMC2688966.
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Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster. PLoS One. 2009; 4(4):e5371. Azad P, Zhou D, Russo E, Haddad GG. PMID: 19401761; PMCID: PMC2670512.
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DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms. J Neurochem. 2009 Feb; 108(3):835-46. Yao H, Felfly H, Wang J, Zhou D, Haddad GG. PMID: 19077053; PMCID: PMC2782475.
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Can O2 dysregulation induce premature aging? Physiology (Bethesda). 2008 Dec; 23:333-49. Douglas RM, Haddad GG. PMID: 19074741.
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Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch. PLoS Genet. 2008 Oct; 4(10):e1000221. Zhou D, Xue J, Lai JC, Schork NJ, White KP, Haddad GG. PMID: 18927626; PMCID: PMC2556400.
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Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain. Brain Res. 2008 Oct 31; 1238:85-92. Chen LM, Haddad GG, Boron WF. PMID: 18775686; PMCID: PMC3222586.
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Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore. Cell Physiol Biochem. 2008; 22(1-4):127-36. Cheng Y, Gu XQ, Bednarczyk P, Wiedemann FR, Haddad GG, Siemen D. PMID: 18769039.
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Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival. Funct Integr Genomics. 2008 Aug; 8(3):265-75. Iacobas DA, Fan C, Iacobas S, Haddad GG. PMID: 18446526; PMCID: PMC2856931.
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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 2008 Jun 05; 453(7196):807-11. Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. PMID: 18432192; PMCID: PMC2669289.
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Epidermal sensing of oxygen is essential for systemic hypoxic response. Cell. 2008 Apr 18; 133(2):223-34. Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS. PMID: 18423195; PMCID: PMC2849644.
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Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development. Pediatr Pulmonol. 2008 Jan; 43(1):20-8. Farahani R, Kanaan A, Gavrialov O, Brunnert S, Douglas RM, Morcillo P, Haddad GG. PMID: 18041750.
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TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn. 2008 Jan; 237(1):259-69. Alejandre-Alcázar MA, Michiels-Corsten M, Vicencio AG, Reiss I, Ryu J, de Krijger RR, Haddad GG, Tibboel D, Seeger W, Eickelberg O, Morty RE. PMID: 18095342.
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The sodium-activated potassium channel Slack is modulated by hypercapnia and acidosis. Neuroscience. 2008 Jan 24; 151(2):410-8. Ruffin VA, Gu XQ, Zhou D, Douglas RM, Sun X, Trouth CO, Haddad GG. PMID: 18082331; PMCID: PMC6620050.
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Chronic continuous hypoxia decreases the expression of SLC4A7 (NBCn1) and SLC4A10 (NCBE) in mouse brain. Am J Physiol Regul Integr Comp Physiol. 2007 Dec; 293(6):R2412-20. Chen LM, Choi I, Haddad GG, Boron WF. PMID: 17928512.
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Cell death in an ischemic infarct rim model. J Neurochem. 2007 Nov; 103(4):1644-53. Yao H, Sun X, Gu X, Wang J, Haddad GG. PMID: 17727626.
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Effect of chronic elevated carbon dioxide on the expression of acid-base transporters in the neonatal and adult mouse. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1294-302. Kanaan A, Douglas RM, Alper SL, Boron WF, Haddad GG. PMID: 17652362.
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Experimental selection for Drosophila survival in extremely low O(2) environment. PLoS One. 2007 May 30; 2(5):e490. Zhou D, Xue J, Chen J, Morcillo P, Lambert JD, White KP, Haddad GG. PMID: 17534440; PMCID: PMC1871610.
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Prostaglandin transporter expression in mouse brain during development and in response to hypoxia. Neuroscience. 2007 May 25; 146(3):1150-7. Scafidi S, Douglas RM, Farahani R, Banasiak KJ, Haddad GG. PMID: 17428614; PMCID: PMC2661356.
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Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia. Physiol Genomics. 2007 May 11; 29(3):260-6. Huang H, Haddad GG. PMID: 17284667.
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Factors influencing cell fate in the infarct rim. J Neurochem. 2007 Mar; 100(5):1224-33. Yao H, Shu Y, Wang J, Brinkman BC, Haddad GG. PMID: 17217421.
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Chronic high-inspired CO2 decreases excitability of mouse hippocampal neurons. J Neurophysiol. 2007 Feb; 97(2):1833-8. Gu XQ, Kanaan A, Yao H, Haddad GG. PMID: 17202241.
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Chronic intermittent but not constant hypoxia decreases NAA/Cr ratios in neonatal mouse hippocampus and thalamus. Am J Physiol Regul Integr Comp Physiol. 2007 Mar; 292(3):R1254-9. Douglas RM, Miyasaka N, Takahashi K, Latuszek-Barrantes A, Haddad GG, Hetherington HP. PMID: 17082353.
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Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid. J Neurophysiol. 2007 Jan; 97(1):62-9. Sun X, Zhou D, Zhang P, Moczydlowski EG, Haddad GG. PMID: 17021030.
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Transcriptomic changes in developing kidney exposed to chronic hypoxia. Biochem Biophys Res Commun. 2006 Oct 13; 349(1):329-38. Iacobas DA, Fan C, Iacobas S, Spray DC, Haddad GG. PMID: 16934745.
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The calcium-sensitive large-conductance potassium channel (BK/MAXI K) is present in the inner mitochondrial membrane of rat brain. Neuroscience. 2006; 139(4):1249-61. Douglas RM, Lai JC, Bian S, Cummins L, Moczydlowski E, Haddad GG. PMID: 16567053.
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Tolerance to low O2: lessons from invertebrate genetic models. Exp Physiol. 2006 Mar; 91(2):277-82. Haddad GG. PMID: 16431936.
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Effect of chronic continuous or intermittent hypoxia and reoxygenation on cerebral capillary density and myelination. Am J Physiol Regul Integr Comp Physiol. 2006 Apr; 290(4):R1105-14. Kanaan A, Farahani R, Douglas RM, Lamanna JC, Haddad GG. PMID: 16322350.
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Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost. 2005 Jul; 94(1):175-83. Ryu J, Vicencio AG, Yeager ME, Kashgarian M, Haddad GG, Eickelberg O. PMID: 16113801.
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Intermittent hypoxia modulates Na+ channel expression in developing mouse brain. Int J Dev Neurosci. 2005 Jun; 23(4):327-33. Zhao P, Xue J, Gu XQ, Haddad GG, Xia Y. PMID: 15927756.
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Gene expression and phenotypic characterization of mouse heart after chronic constant or intermittent hypoxia. Physiol Genomics. 2005 Aug 11; 22(3):292-307. Fan C, Iacobas DA, Zhou D, Chen Q, Lai JK, Gavrialov O, Haddad GG. PMID: 15928208; PMCID: PMC2856928.
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Regulatory role of dADAR in ROS metabolism in Drosophila CNS. Brain Res Mol Brain Res. 2004 Nov 24; 131(1-2):93-100. Chen L, Rio DC, Haddad GG, Ma E. PMID: 15530657.
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Identification of new targets of Drosophila pre-mRNA adenosine deaminase. Physiol Genomics. 2005 Jan 20; 20(2):195-202. Xia S, Yang J, Su Y, Qian J, Ma E, Haddad GG. PMID: 15522950.
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Hypoxia induces major effects on cell cycle kinetics and protein expression in Drosophila melanogaster embryos. Am J Physiol Regul Integr Comp Physiol. 2005 Feb; 288(2):R511-21. Douglas RM, Farahani R, Morcillo P, Kanaan A, Xu T, Haddad GG. PMID: 15498965.
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Calcium and pH homeostasis in neurons during hypoxia and ischemia. Cell Calcium. 2004 Sep-Oct; 36(3-4):247-55. Yao H, Haddad GG. PMID: 15261480.
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Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? Am J Respir Cell Mol Biol. 2004 Dec; 31(6):650-6. Vicencio AG, Lee CG, Cho SJ, Eickelberg O, Chuu Y, Haddad GG, Elias JA. PMID: 15333328.
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Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol. 2004 Aug; 207(Pt 18):3125-9. Chen Q, Haddad GG. PMID: 15299033.
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Effect of chronically elevated CO2 on CA1 neuronal excitability. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C691-7. Gu XQ, Xue J, Haddad GG. PMID: 15115704.
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Activation of voltage-sensitive sodium channels during oxygen deprivation leads to apoptotic neuronal death. Neuroscience. 2004; 126(1):31-44. Banasiak KJ, Burenkova O, Haddad GG. PMID: 15145071.
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A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15184-9. Kuan CY, Whitmarsh AJ, Yang DD, Liao G, Schloemer AJ, Dong C, Bao J, Banasiak KJ, Haddad GG, Flavell RA, Davis RJ, Rakic P. PMID: 14657393; PMCID: PMC299947.
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Expression of Drosophila trehalose-phosphate synthase in HEK-293 cells increases hypoxia tolerance. J Biol Chem. 2003 Dec 05; 278(49):49113-8. Chen Q, Behar KL, Xu T, Fan C, Haddad GG. PMID: 13129920.
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Chronic hypoxia in development selectively alters the activities of key enzymes of glucose oxidative metabolism in brain regions. Neurochem Res. 2003 Jun; 28(6):933-40. Lai JC, White BK, Buerstatte CR, Haddad GG, Novotny EJ, Behar KL. PMID: 12718448.
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Understanding the molecular responses to hypoxia using Drosophila as a genetic model. Respir Physiol Neurobiol. 2003 May 30; 135(2-3):221-9. Farahani R, Haddad GG. PMID: 12809621.
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Calcium influx via L- and N-type calcium channels activates a transient large-conductance Ca2+-activated K+ current in mouse neocortical pyramidal neurons. J Neurosci. 2003 May 01; 23(9):3639-48. Sun X, Gu XQ, Haddad GG. PMID: 12736335; PMCID: PMC6742183.
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Maturation of neuronal excitability in hippocampal neurons of mice chronically exposed to cyclic hypoxia. Am J Physiol Cell Physiol. 2003 May; 284(5):C1156-63. Gu XQ, Haddad GG. PMID: 12676654.
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Genetic models in applied physiology: invited review: effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest. J Appl Physiol (1985). 2003 May; 94(5):2068-83; discussion 2084. Douglas RM, Haddad GG. PMID: 12679355.
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Chronic intermittent hypoxia decreases the expression of Na/H exchangers and HCO3-dependent transporters in mouse CNS. J Appl Physiol (1985). 2003 Jul; 95(1):292-9. Douglas RM, Xue J, Chen JY, Haddad CG, Alper SL, Haddad GG. PMID: 12665539.
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The role of HCO3(-)-dependent mechanisms in pHi regulation during O2 deprivation. Neuroscience. 2003; 117(1):29-35. Yao H, Gu XQ, Haddad GG. PMID: 12605889.
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Intracellular pH activates membrane-bound Na(+)/H(+) exchanger and vacuolar H(+)-ATPase in human embryonic kidney (HEK) cells. Cell Physiol Biochem. 2003; 13(5):257-62. Lang K, Wagner C, Haddad G, Burnekova O, Geibel J. PMID: 14586169.
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Na+ channel expression and neuronal function in the Na+/H+ exchanger 1 null mutant mouse. J Neurophysiol. 2003 Jan; 89(1):229-36. Xia Y, Zhao P, Xue J, Gu XQ, Sun X, Yao H, Haddad GG. PMID: 12522174.
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Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J Appl Physiol (1985). 2002 Sep; 93(3):1123-30. Vicencio AG, Eickelberg O, Stankewich MC, Kashgarian M, Haddad GG. PMID: 12183510.
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Developmental expression and enzymatic activity of pre-mRNA deaminase in Drosophila melanogaster. Brain Res Mol Brain Res. 2002 Jun 15; 102(1-2):100-4. Ma E, Tucker MC, Chen Q, Haddad GG. PMID: 12191498.
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Slot-blot hybridization in studying gene expression during oxygen deprivation. Methods Mol Biol. 2002; 196:139-45. Ma E, Haddad GG. PMID: 12152192.
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Na(+)/Ca(2+) exchanger expression in the developing rat cortex. Neuroscience. 2002; 112(1):65-73. Gibney GT, Zhang JH, Douglas RM, Haddad GG, Xia Y. PMID: 12044472.
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Neuronal tolerance to O2 deprivation in drosophila: novel approaches using genetic models. Neuroscientist. 2001 Dec; 7(6):538-50. Haddad GG, Ma E. PMID: 11765131.
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Role of trehalose phosphate synthase in anoxia tolerance and development in Drosophila melanogaster. J Biol Chem. 2002 Feb 01; 277(5):3274-9. Chen Q, Ma E, Behar KL, Xu T, Haddad GG. PMID: 11719513.
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Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1205-10. Yao H, Gu XQ, Douglas RM, Haddad GG. PMID: 11546657.
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Decreased neuronal excitability in hippocampal neurons of mice exposed to cyclic hypoxia. J Appl Physiol (1985). 2001 Sep; 91(3):1245-50. Gu XQ, Haddad GG. PMID: 11509522.
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Increased neuronal excitability and seizures in the Na(+)/H(+) exchanger null mutant mouse. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C496-503. Gu XQ, Yao H, Haddad GG. PMID: 11443048.
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Major difference in the expression of delta- and mu-opioid receptors between turtle and rat brain. J Comp Neurol. 2001 Jul 23; 436(2):202-10. Xia Y, Haddad GG. PMID: 11438924.
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Cell cycle progression and cell division are sensitive to hypoxia in Drosophila melanogaster embryos. Am J Physiol Regul Integr Comp Physiol. 2001 May; 280(5):R1555-63. Douglas RM, Xu T, Haddad GG. PMID: 11294781.
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Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest. 2001 Mar; 107(6):685-93. Ma E, Gu XQ, Wu X, Xu T, Haddad GG. PMID: 11254668; PMCID: PMC208948.
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Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitro. Brain Res. 2001 Jan 12; 888(2):193-202. Novotny EJ, Ariyan C, Mason GF, O'Reilly J, Haddad GG, Behar KL. PMID: 11150475.
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Sodium-hydrogen exchangers and sodium-bicarbonate co-transporters: ontogeny of protein expression in the rat brain. Neuroscience. 2001; 102(1):217-28. Douglas RM, Schmitt BM, Xia Y, Bevensee MO, Biemesderfer D, Boron WF, Haddad GG. PMID: 11226686.
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delta-, but not mu- and kappa-, opioid receptor activation protects neocortical neurons from glutamate-induced excitotoxic injury. Brain Res. 2000 Dec 08; 885(2):143-53. Zhang J, Haddad GG, Xia Y. PMID: 11102568.
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Effect of extracellular HCO(3)(-) on Na(+) channel characteristics in hippocampal CA1 neurons. J Neurophysiol. 2000 Nov; 84(5):2477-83. Gu XQ, Yao H, Haddad GG. PMID: 11067990.
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Mechanisms underlying hypoxia-induced neuronal apoptosis. Prog Neurobiol. 2000 Oct; 62(3):215-49. Banasiak KJ, Xia Y, Haddad GG. PMID: 10840148.
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Na/HCO3 cotransporters in rat brain: expression in glia, neurons, and choroid plexus. J Neurosci. 2000 Sep 15; 20(18):6839-48. Schmitt BM, Berger UV, Douglas RM, Bevensee MO, Hediger MA, Haddad GG, Boron WF. PMID: 10995828; PMCID: PMC6772819.
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Enhancing our understanding of the molecular responses to hypoxia in mammals using Drosophila melanogaster. J Appl Physiol (1985). 2000 Apr; 88(4):1481-7. Haddad GG. PMID: 10749845.
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Increased neuronal excitability after long-term O(2) deprivation is mediated mainly by sodium channels. Brain Res Mol Brain Res. 2000 Mar 29; 76(2):211-9. Xia Y, Fung ML, O'Reilly JP, Haddad GG. PMID: 10762696.
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Different O2-sensing mechanisms by different K+ channels. Adv Exp Med Biol. 2000; 475:441-52. Haddad GG, Liu H. PMID: 10849685.
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Isolation and characterization of the hypoxia-inducible factor 1beta in Drosophila melanogaster. Brain Res Mol Brain Res. 1999 Nov 10; 73(1-2):11-6. Ma E, Haddad GG. PMID: 10581393.
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Sodium homeostasis in rat hippocampal slices during oxygen and glucose deprivation: role of voltage-sensitive sodium channels. Neurosci Lett. 1999 Nov 05; 275(1):41-4. Fung ML, Croning MD, Haddad GG. PMID: 10554980.
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Use of genetic models in respiratory neurobiology and sleep. Curr Opin Pulm Med. 1999 Nov; 5(6):349-54. Haddad GG. PMID: 10570735.
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Drosophila neurons respond differently to hypoxia and cyanide than rat neurons. Brain Res. 1999 Oct 16; 845(1):6-13. Gu XQ, Haddad GG. PMID: 10529438.
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bcl-2 prolongs neuronal survival during hypoxia-induced apoptosis. Brain Res Mol Brain Res. 1999 Oct 01; 72(2):214-25. Banasiak KJ, Cronin T, Haddad GG. PMID: 10529480.
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Intracellular pH regulation of CA1 neurons in Na(+)/H(+) isoform 1 mutant mice. J Clin Invest. 1999 Sep; 104(5):637-45. Yao H, Ma E, Gu XQ, Haddad GG. PMID: 10487778; PMCID: PMC408538.
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O(2) deprivation inhibits Ca(2+)-activated K(+) channels via cytosolic factors in mice neocortical neurons. J Clin Invest. 1999 Sep; 104(5):577-88. Liu H, Moczydlowski E, Haddad GG. PMID: 10487772; PMCID: PMC408544.
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A Drosophila CDK5alpha-like molecule and its possible role in response to O(2) deprivation. Biochem Biophys Res Commun. 1999 Aug 02; 261(2):459-63. Ma E, Haddad G. PMID: 10425207.
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Gene regulation by O2 deprivation: an anoxia-regulated novel gene in Drosophila melanogaster. Brain Res Mol Brain Res. 1999 Jan 08; 63(2):217-24. Ma E, Xu T, Haddad GG. PMID: 9878744.
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Effect of prolonged O2 deprivation on Na+ channels: differential regulation in adult versus fetal rat brain. Neuroscience. 1999; 94(4):1231-43. Xia Y, Haddad GG. PMID: 10625063.
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Neuroprotective interactions in rats between paclitaxel and cisplatin. Oncol Res. 1999; 11(6):287-93. McKeage MJ, Haddad GG, Ding L, Galettis P, Screnci D, Zhuang L, Baguley BC. PMID: 10691031.
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Hypoxia-induced apoptosis: effect of hypoxic severity and role of p53 in neuronal cell death. Brain Res. 1998 Jun 29; 797(2):295-304. Banasiak KJ, Haddad GG. PMID: 9666152.
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Comparison of brain slice chamber designs for investigations of oxygen deprivation in vitro. J Neurosci Methods. 1998 Jun 01; 81(1-2):103-11. Croning MD, Haddad GG. PMID: 9696315.
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Differential effects of anoxia and glutamate on cultured neocortical neurons. Exp Neurol. 1998 Mar; 150(1):52-9. Chow E, Haddad GG. PMID: 9514836.
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State of actin filaments is changed by anoxia in cultured rat neocortical neurons. Neuroscience. 1998 Jan; 82(2):421-7. Friedman JE, Chow EJ, Haddad GG. PMID: 9466451.
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Mechanisms of anoxia tolerance. A novel approach using a Drosophila model system. Adv Exp Med Biol. 1998; 454:273-80. Haddad GG. PMID: 9889901.
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Effect of chronic hypoxia on glucose transporters in heart and skeletal muscle of immature and adult rats. Am J Physiol. 1997 11; 273(5):R1734-41. Xia Y, Warshaw JB, Haddad GG. PMID: 9374817.
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Genetic basis of tolerance to O2 deprivation in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10809-12. Haddad GG, Sun Ya, Wyman RJ, Xu T. PMID: 9380715; PMCID: PMC23494.
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Oxygen deprivation inhibits Na+ current in rat hippocampal neurones via protein kinase C. J Physiol. 1997 Sep 15; 503 ( Pt 3):479-88. O'Reilly JP, Cummins TR, Haddad GG. PMID: 9379405; PMCID: PMC1159835.
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Standardization of a single-cell assay for sensitive detection of multidrug resistance protein expression in normal and malignant cells in archival clinical samples. J Lab Clin Med. 1997 Sep; 130(3):297-306. Chan HS, Grogan TM, Haddad G, Hipfner DR, Deeley RG, Cole SP. PMID: 9341990.
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Anoxia-induced neuronal injury: role of Na+ entry and Na+-dependent transport. Exp Neurol. 1997 Aug; 146(2):403-13. Chidekel AS, Friedman JE, Haddad GG. PMID: 9270051.
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Anoxia-induced depolarization in CA1 hippocampal neurons: role of Na+-dependent mechanisms. Brain Res. 1997 Jul 11; 762(1-2):97-102. Fung ML, Haddad GG. PMID: 9262163.
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Expression and localization of Na+/H+ exchangers in rat central nervous system. Neuroscience. 1997 Jul; 79(2):591-603. Ma E, Haddad GG. PMID: 9200742.
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Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein. Cancer Res. 1997 Jun 15; 57(12):2325-30. Chan HS, Lu Y, Grogan TM, Haddad G, Hipfner DR, Cole SP, Deeley RG, Ling V, Gallie BL. PMID: 9192801.
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Anoxia regulates gene expression in the central nervous system of Drosophila melanogaster. Brain Res Mol Brain Res. 1997 Jun; 46(1-2):325-8. Ma E, Haddad GG. PMID: 9191110.
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Behavioral and Electrophysiologic Responses of Drosophila melanogaster to Prolonged Periods of Anoxia. J Insect Physiol. 1997 Mar; 43(3):203-210. HADDAD GG, WYMAN RJ, MOHSENIN A, SUN Y, KRISHNAN SN. PMID: 12769903.
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K+ ions and channels: mechanisms of sensing O2 deprivation in central neurons. Kidney Int. 1997 Feb; 51(2):467-72. Haddad GG. PMID: 9027723.
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Modulation of K+ channels by intracellular ATP in human neocortical neurons. J Neurophysiol. 1997 Jan; 77(1):93-102. Jiang C, Haddad GG. PMID: 9120601.
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O2-sensing mechanisms in excitable cells: role of plasma membrane K+ channels. Annu Rev Physiol. 1997; 59:23-42. Haddad GG, Jiang C. PMID: 9074755.
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Vulnerability of CA1 neurons to glutamate is developmentally regulated. Brain Res Dev Brain Res. 1996 Dec 23; 97(2):194-206. Marks JD, Friedman JE, Haddad GG. PMID: 8997504.
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pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats. J Physiol. 1996 Jul 15; 494 ( Pt 2):315-28. Bevensee MO, Cummins TR, Haddad GG, Boron WF, Boyarsky G. PMID: 8841993; PMCID: PMC1160636.
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Chronic hypoxia in vivo renders neocortical neurons more vulnerable to subsequent acute hypoxic stress. Brain Res. 1996 Mar 04; 711(1-2):203-10. O'Reilly JP, Haddad GG. PMID: 8680864.
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Modulation of Ca2+ and Na+ transport by taurine in heart and vascular smooth muscle. Adv Exp Med Biol. 1996; 403:263-73. Bkaily G, Haddad G, Jaalouk D, Gros-Louis N, Benchekroun MT, Naik R, Pothier P, D'Orléans-Juste P, Bui M, Wang S, Sperelakis N. PMID: 8915363.
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Isolation and chromosomal localization of a human ATP-regulated potassium channel. Hum Genet. 1995 Aug; 96(2):155-60. Krishnan SN, Desai T, Ward DC, Haddad GG. PMID: 7635463.
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Major differences in response to graded hypoxia between hypoglossal and neocortical neurons. Brain Res. 1995 Jun 19; 683(2):179-86. O'Reilly JP, Jiang C, Haddad GG. PMID: 7552353.
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Chronic hypoxia causes opposite effects on glucose transporter 1 mRNA in mature versus immature rat brain. Brain Res. 1995 Mar 27; 675(1-2):224-30. Xia Y, Warshaw JB, Haddad GG. PMID: 7796133.
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Cloning of glucose transporter-3 (GLUT3) cDNA from rat brain. Life Sci. 1995; 56(14):1193-7. Krishnan SN, Haddad GG. PMID: 7475896.
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Oxygen deprivation inhibits a K+ channel independently of cytosolic factors in rat central neurons. J Physiol. 1994 Nov 15; 481 ( Pt 1):15-26. Jiang C, Haddad GG. PMID: 7853238; PMCID: PMC1155862.
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Anoxia induces an increase in intracellular sodium in rat central neurons in vitro. Brain Res. 1994 Nov 14; 663(2):329-34. Friedman JE, Haddad GG. PMID: 7874519.
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Oxygen deprivation activates an ATP-inhibitable K+ channel in substantia nigra neurons. J Neurosci. 1994 Sep; 14(9):5590-602. Jiang C, Sigworth FJ, Haddad GG. PMID: 8083755; PMCID: PMC6577106.
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A direct mechanism for sensing low oxygen levels by central neurons. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7198-201. Jiang C, Haddad GG. PMID: 8041769; PMCID: PMC44366.
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Postnatal development of voltage-sensitive Na+ channels in rat brain. J Comp Neurol. 1994 Jul 08; 345(2):279-87. Xia Y, Haddad GG. PMID: 7929902.
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Removal of extracellular sodium prevents anoxia-induced injury in freshly dissociated rat CA1 hippocampal neurons. Brain Res. 1994 Mar 28; 641(1):57-64. Friedman JE, Haddad GG. PMID: 8019852.
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Functional properties of rat and human neocortical voltage-sensitive sodium currents. J Neurophysiol. 1994 Mar; 71(3):1052-64. Cummins TR, Xia Y, Haddad GG. PMID: 8201401.
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Voltage-sensitive Na+ channels increase in number in newborn rat brain after in utero hypoxia. Brain Res. 1994 Jan 28; 635(1-2):339-44. Xia Y, Haddad GG. PMID: 8173974.
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Mechanisms of neuronal survival during hypoxia: ATP-sensitive K+ channels. Biol Neonate. 1994; 65(3-4):160-5. Haddad GG, Jiang C. PMID: 8038277.
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Membrane ionic currents and properties of freshly dissociated rat brainstem neurons. Exp Brain Res. 1994; 100(3):407-20. Jiang C, Cummins TR, Haddad GG. PMID: 7813679.
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Severe hypoxemia in children with upper airway obstruction during sleep does not lead to significant changes in heart rate. Pediatr Pulmonol. 1993 Dec; 16(6):362-9. D'Andrea LA, Rosen CL, Haddad GG. PMID: 8134159.
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Sulfonylurea receptor expression in rat brain: effect of chronic hypoxia during development. Pediatr Res. 1993 Nov; 34(5):634-41. Xia Y, Eisenman D, Haddad GG. PMID: 8284102.
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Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat. Brain Res. 1993 Oct 22; 625(2):261-8. Haddad GG, Jiang C. PMID: 7903900.
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Acute anoxia-induced alterations in MAP2 immunoreactivity and neuronal morphology in rat hippocampus. Brain Res. 1993 Aug 27; 620(2):203-10. Kwei S, Jiang C, Haddad GG. PMID: 8369956.
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Short periods of hypoxia activate a K+ current in central neurons. Brain Res. 1993 Jun 18; 614(1-2):352-6. Jiang C, Haddad GG. PMID: 8348327.
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Neuroanatomical distribution and binding properties of saxitoxin sites in the rat and turtle CNS. J Comp Neurol. 1993 Apr 15; 330(3):363-80. Xia Y, Haddad GG. PMID: 8468412.
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Effect of anoxia on excitatory amino acids in brain slices of rats and turtles: in vitro microdialysis. Am J Physiol. 1993 Apr; 264(4 Pt 2):R716-9. Young RS, During MJ, Donnelly DF, Aquila WJ, Perry VL, Haddad GG. PMID: 8097385.
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O2 deprivation in the central nervous system: on mechanisms of neuronal response, differential sensitivity and injury. Prog Neurobiol. 1993 Mar; 40(3):277-318. Haddad GG, Jiang C. PMID: 7680137.
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Oxygen tension clamp around single neurons in vitro: a computerized method for studies on O2 deprivation. J Neurosci Methods. 1993 Mar; 46(3):183-9. Cummins TR, Agulian SK, Haddad GG. PMID: 8483311.
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Effect of acute hypoxia on metabolism and ventilation in awake piglets. Respir Physiol. 1993 Mar; 91(2-3):307-19. Rosen CL, Schecter WS, Mellins RB, Haddad GG. PMID: 8469853.
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Human neocortical excitability is decreased during anoxia via sodium channel modulation. J Clin Invest. 1993 Feb; 91(2):608-15. Cummins TR, Jiang C, Haddad GG. PMID: 8381823; PMCID: PMC287992.
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Major differences in Ca2+i response to anoxia between neonatal and adult rat CA1 neurons: role of Ca2+o and Na+o. J Neurosci. 1993 Jan; 13(1):63-72. Friedman JE, Haddad GG. PMID: 8093716; PMCID: PMC6576297.
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Differential responses of neocortical neurons to glucose and/or O2 deprivation in the human and rat. J Neurophysiol. 1992 Dec; 68(6):2165-73. Jiang C, Haddad GG. PMID: 1491265.
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Adult criteria for obstructive sleep apnea do not identify children with serious obstruction. Am Rev Respir Dis. 1992 Nov; 146(5 Pt 1):1231-4. Rosen CL, D'Andrea L, Haddad GG. PMID: 1443876.
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Autoresuscitation: a survival mechanism in piglets. J Appl Physiol (1985). 1992 Aug; 73(2):749-53. Sanocka UM, Donnelly DF, Haddad GG. PMID: 1400005.
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Ontogeny and distribution of GABAA receptors in rat brainstem and rostral brain regions. Neuroscience. 1992 Aug; 49(4):973-89. Xia Y, Haddad GG. PMID: 1331860.
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Comparative responses of brain stem and hippocampal neurons to O2 deprivation: in vitro intracellular studies. Am J Physiol. 1992 May; 262(5 Pt 1):L549-54. Donnelly DF, Jiang C, Haddad GG. PMID: 1590406.
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Oxidative and glycolytic pathways in rat (newborn and adult) and turtle brain: role during anoxia. Am J Physiol. 1992 Apr; 262(4 Pt 2):R595-603. Xia Y, Jiang C, Haddad GG. PMID: 1314516.
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Role of ATP-sensitive K+ channels during anoxia: major differences between rat (newborn and adult) and turtle neurons. J Physiol. 1992 Mar; 448:599-612. Jiang C, Xia Y, Haddad GG. PMID: 1593480; PMCID: PMC1176218.
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Cl- and Na+ homeostasis during anoxia in rat hypoglossal neurons: intracellular and extracellular in vitro studies. J Physiol. 1992 Mar; 448:697-708. Jiang C, Agulian S, Haddad GG. PMID: 1593484; PMCID: PMC1176223.
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O2 tension in adult and neonatal brain slices under several experimental conditions. Brain Res. 1991 Dec 24; 568(1-2):159-64. Jiang C, Agulian S, Haddad GG. PMID: 1814564.
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Major differences in CNS sulfonylurea receptor distribution between the rat (newborn, adult) and turtle. J Comp Neurol. 1991 Dec 08; 314(2):278-89. Xia Y, Haddad GG. PMID: 1787178.
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Effect of metabolic inhibition on the excitability of isolated hippocampal CA1 neurons: developmental aspects. J Neurophysiol. 1991 Nov; 66(5):1471-82. Cummins TR, Donnelly DF, Haddad GG. PMID: 1662712.
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Multidrug-resistant phenotype in retinoblastoma correlates with P-glycoprotein expression. Ophthalmology. 1991 Sep; 98(9):1425-31. Chan HS, Thorner PS, Haddad G, Gallie BL. PMID: 1682862.
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Developmental changes in neuromuscular transmission in the rat diaphragm. J Appl Physiol (1985). 1991 Jul; 71(1):280-6. Feldman JD, Bazzy AR, Cummins TR, Haddad GG. PMID: 1655690.
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Effect of anoxia on intracellular and extracellular potassium activity in hypoglossal neurons in vitro. J Neurophysiol. 1991 Jul; 66(1):103-11. Jiang C, Haddad GG. PMID: 1919660.
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Ontogeny and distribution of opioid receptors in the rat brainstem. Brain Res. 1991 May 24; 549(2):181-93. Xia Y, Haddad GG. PMID: 1653081.
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O2 deprivation induces a major depolarization in brain stem neurons in the adult but not in the neonatal rat. J Physiol. 1990 Oct; 429:411-28. Haddad GG, Donnelly DF. PMID: 2126043; PMCID: PMC1181708.
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Biophysical properties of hypoglossal neurons in vitro: intracellular studies in adult and neonatal rats. J Appl Physiol (1985). 1990 Oct; 69(4):1509-17. Haddad GG, Donnelly DF, Getting PA. PMID: 2262474.
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Membrane and cellular properties in oscillating networks: implications for respiration. J Appl Physiol (1985). 1990 Sep; 69(3):809-21. Dekin MS, Haddad GG. PMID: 2246168.
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Effect of sleep on regional blood flow distribution in piglets. Pediatr Res. 1990 Sep; 28(3):218-22. Cote A, Haddad GG. PMID: 2235117.
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Prolonged apnea and impaired survival in piglets after sinus and aortic nerve section. J Appl Physiol (1985). 1990 Mar; 68(3):1048-52. Donnelly DF, Haddad GG. PMID: 2341332.
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Repetitive firing properties of neurons in the ventral region of nucleus tractus solitarius. In vitro studies in adult and neonatal rat. J Neurophysiol. 1989 Dec; 62(6):1213-24. Haddad GG, Getting PA. PMID: 2600620.
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Plasma beta-casomorphin-7 immunoreactive peptide increases after milk intake in newborn but not in adult dogs. Pediatr Res. 1989 Jul; 26(1):34-8. Singh M, Rosen CL, Chang KJ, Haddad GG. PMID: 2771507.
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Effect of enkephalins on cardiac output and regional blood flow in conscious dogs. Am J Physiol. 1989 Jun; 256(6 Pt 2):H1651-8. Rosen CL, Cote A, Haddad GG. PMID: 2500032.
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O2 metabolism of the sheep diaphragm during flow resistive loaded breathing. J Appl Physiol (1985). 1989 May; 66(5):2305-11. Bazzy AR, Pang LM, Akabas SR, Haddad GG. PMID: 2745294.
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Metabolic and functional adaptation of the diaphragm to training with resistive loads. J Appl Physiol (1985). 1989 Feb; 66(2):529-35. Akabas SR, Bazzy AR, DiMauro S, Haddad GG. PMID: 2540138.
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Ventilatory response to moderate and severe hypoxia in adult dogs: role of endorphins. J Appl Physiol (1985). 1988 Sep; 65(3):1383-8. Schaeffer JI, Haddad GG. PMID: 3141354.
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Respiratory muscle response to load and glycogen content in type I and II fibers. Exp Neurol. 1988 Jul; 101(1):17-28. Bazzy AR, Akabas SR, Hays AP, Haddad GG. PMID: 3391257.
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Cardiovascular and neurophysiologic changes during graded duration of apnea in piglets. Pediatr Res. 1988 Apr; 23(4):402-7. Sanocka UM, Donnelly DF, Haddad GG. PMID: 3374994.
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Heart rate variability during respiratory pauses in puppies and dogs. Pediatr Res. 1987 Sep; 22(3):306-11. Haddad GG, Jeng HJ, Lai TL. PMID: 3658551.
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Determination of sleep state in infants using respiratory variability. Pediatr Res. 1987 Jun; 21(6):556-62. Haddad GG, Jeng HJ, Lai TL, Mellins RB. PMID: 3601474.
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Within-breath electromyographic changes during loaded breathing in adult sheep. J Appl Physiol (1985). 1986 Oct; 61(4):1316-21. Haddad GG, Jeng HJ, Bazzy AR, Lai TL. PMID: 3781946.
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Increase in electromyogram low-frequency power in nonfatigued contracting skeletal muscle. J Appl Physiol (1985). 1986 Sep; 61(3):1012-7. Bazzy AR, Korten JB, Haddad GG. PMID: 3759739.
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Respiratory changes induced by prolonged laryngeal stimulation in awake piglets. J Appl Physiol (1985). 1986 Sep; 61(3):1018-24. Donnelly DF, Haddad GG. PMID: 3759740.
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Regulation of ventilation and oxygen consumption by delta- and mu-opioid receptor agonists. J Appl Physiol (1985). 1985 Sep; 59(3):959-68. Schaeffer JI, Haddad GG. PMID: 2997105.
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Ventilatory response to fatiguing and nonfatiguing resistive loads in awake sheep. J Appl Physiol (1985). 1985 Sep; 59(3):969-78. Sadoul N, Bazzy AR, Akabas SR, Haddad GG. PMID: 4055582.
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Opposite effects of the delta- and mu-opioid receptor agonists on ventilation in conscious adult dogs. Brain Res. 1984 Dec 03; 323(1):73-82. Haddad GG, Schaeffer JI, Chang KJ. PMID: 6098337.
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Hypoxia and respiratory control in early life. Annu Rev Physiol. 1984; 46:629-43. Haddad GG, Mellins RB. PMID: 6143533.
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Cardiorespiratory control in sudden infant death syndrome. Prog Clin Biol Res. 1983; 136:51-7. Mellins RB, Haddad GG. PMID: 6420807.
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Respiratory control in early life: an overview. Prog Clin Biol Res. 1983; 136:3-15. Mellins RB, Haddad GG. PMID: 6364172.
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Maturation of ventilatory response to hypoxia in puppies during sleep. J Appl Physiol Respir Environ Exerc Physiol. 1982 Feb; 52(2):309-14. Haddad GG, Gandhi MR, Mellins RB. PMID: 7061286.
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Abnormal maturation of sleep states in infants with aborted sudden infant death syndrome. Pediatr Res. 1981 Jul; 15(7):1055-7. Haddad GG, Walsh EM, Leistner HL, Grodin WK, Mellins RB. PMID: 7254951.
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Ventilation and ventilatory pattern during sleep in aborted sudden infant death syndrome. Pediatr Res. 1981 May; 15(5):879-83. Haddad GG, Leistner HL, Lai TL, Mellins RB. PMID: 6787545.
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The R-R interval and R-R variability in normal infants during sleep. Pediatr Res. 1980 Jun; 14(6):809-11. Haddad GG, Epstein RA, Epstein MA, Leistner HL, Mellins RB. PMID: 7402755.
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CO2-induced changes in ventilation and ventilatory pattern in normal sleeping infants. J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr; 48(4):684-8. Haddad GG, Leistner HL, Epstein RA, Epstein MA, Grodin WK, Mellins RB. PMID: 6769883.
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Relation of beat-to-beat variability to heart rate in normal sleeping infants. Pediatr Res. 1980 Mar; 14(3):232-5. Mazza NM, Epstein MA, Haddad GG, Law HS, Mellins RB, Epstein RA. PMID: 7383743.
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Effect of sleep state on the QT interval in normal infants. Pediatr Res. 1979 Feb; 13(2):139-41. Haddad GG, Krongrad E, Epstein RA, Epstein MA, Law HS, Katz JB, Mazza NM, Mellins RB. PMID: 219413.
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The QT interval in aborted sudden infant death syndrome infants. Pediatr Res. 1979 Feb; 13(2):136-8. Haddad GG, Epstein MA, Epstein RA, Mazza NM, Mellins RB, Krongrad E. PMID: 219412.
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The role of airway receptors in the control of respiration in infants: a review. J Pediatr. 1977 Aug; 91(2):281-6. Haddad GG, Mellins RB. PMID: 874688.
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Fracture of bone materials in compression at temperatures between -200 degree C and +200 degree C. Nature. 1971 Aug 20; 232(5312):576-7. Armstrong RW, Arkayin B, Haddad G. PMID: 4937508.
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