1. Nolte E, McKee M. Does healthcare save lives? Avoidable mortality revisited. London: Nuffield Trust; 2004.

    Google Scholar 

  2. GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 2017;390(10091):231–66.

    Article  Google Scholar 

  3. Hart JT. The inverse care law. Lancet. 1971;1(7696):405–12.

    Article  CAS  PubMed  Google Scholar 

  4. World Bank Group. Africa’s pulse, No. 16. Washington, DC: World Bank; 2017.

    Google Scholar 

  5. The Equality Trust. The cost of inequality. London: The Equality Trust; 2014.

    Google Scholar 

  6. WHO. The Abuja Declaration ten years on. Geneva: WHO; 2011.

  7. Nattrass N, Hodes R, Cluver L. Changing donor funding and the challenges of integrated HIV treatment. AMA J Ethics. 2016;18(7):681–90.

    Article  PubMed  Google Scholar 

  8. Banks N, Hulme D, Edwards M. NGOs, states, and donors revisited: still too close for comfort? World Dev. 2014;66:707–18.

    Article  Google Scholar 

  9. Eccles MP, Mittman BS. Welcome to implementation science. Implement Sci. 2006;1(1):1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1436009/.

  10. Nilsen P. Making sense of implementation theories, models and frameworks. Implement Sci. 2015;10:53.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Cochrane LJ, Olson CA, Murray S, Dupuis M, Tooman T, Hayes S. Gaps between knowing and doing: understanding and assessing the barriers to optimal health care. J Contin Educ Heal Prof. 2007;27(2):94–102.

    Article  Google Scholar 

  12. Durlak JA, DuPre EP. Implementation matters: a review of research on the influence of implementation on program outcomes and the factors affecting implementation. Am J Community Psychol. 2008;41(3–4):327–50.

    Article  PubMed  Google Scholar 

  13. Gurses AP, Marsteller JA, Ozok AA, Xiao Y, Owens S, Pronovost PJ. Using an interdisciplinary approach to identify factors that affect clinicians’ compliance with evidence-based guidelines. Crit Care Med. 2010;38(8 Suppl):S282–91.

    Article  PubMed  Google Scholar 

  14. Huberman M. Research utilization: the state of the art. Knowl Policy. 1994;7(4):13–33.

    Article  Google Scholar 

  15. Davis SM, Peterson JC, Helfrich CD, Cunningham-Sabo L. Introduction and conceptual model for utilization of prevention research. Am J Prev Med. 2007;33(1 Suppl):S1–5.

    Article  PubMed  Google Scholar 

  16. Stetler CB. Refinement of the Stetler/Marram model for application of research findings to practice. Nurs Outlook. 1994;42(1):15–25.

    Article  CAS  PubMed  Google Scholar 

  17. Logan J, Graham I. Toward a comprehensive interdisciplinary model of health care research use. Sci Commun. 1998;20:227–46.

    Article  Google Scholar 

  18. Grol R, Wensing M. What drives change? Barriers to and incentives for achieving evidence-based practice. Med J Aust. 2004;180(6 Suppl):S57–60.

    PubMed  Google Scholar 

  19. Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: a model for large scale knowledge translation. BMJ. 2008;337:a1714.

    Article  PubMed  Google Scholar 

  20. Field B, Booth A, Ilott I, Gerrish K. Using the knowledge to action framework in practice: a citation analysis and systematic review. Implement Sci. 2014;9:172.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Damschroder LJ, Aron DC, Keith RE, Kirsh SR, Alexander JA, Lowery JC. Fostering implementation of health services research findings into practice: a consolidated framework for advancing implementation science. Implement Sci. 2009;4:50.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kitson AL, Rycroft-Malone J, Harvey G, McCormack B, Seers K, Titchen A. Evaluating the successful implementation of evidence into practice using the PARiHS framework: theoretical and practical challenges. Implement Sci. 2008;3:1.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Meyers DC, Durlak JA, Wandersman A. The quality implementation framework: a synthesis of critical steps in the implementation process. Am J Community Psychol. 2012;50(3–4):462–80.

    Article  PubMed  Google Scholar 

  24. Greenhalgh T, Robert G, Macfarlane F, Bate P, Kyriakidou O. Diffusion of innovations in service organizations: systematic review and recommendations. Milbank Q. 2004;82(4):581–629.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Weiner BJ. A theory of organizational readiness for change. Implement Sci. 2009;4:67.

    Article  PubMed  PubMed Central  Google Scholar 

  26. May C, Finch T, Mair F, Ballini L, Dowrick C, Eccles M, Gask L, MacFarlane A, Murray E, Rapley T, et al. Understanding the implementation of complex interventions in health care: the normalization process model. BMC Health Serv Res. 2007;7:148.

    Article  PubMed  PubMed Central  Google Scholar 

  27. May CR, Mair F, Finch T, MacFarlane A, Dowrick C, Treweek S, Rapley T, Ballini L, Ong BN, Rogers A, et al. Development of a theory of implementation and integration: normalization process theory. Implement Sci. 2009;4:29.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Stetler CB. Stetler model. In: Rycroft-Malone J, Bucknall T, editors. Models and frameworks for implementing evidence-based practice: linking evidence to action. Oxford: Wiley-Blackwell; 2010. p. 51–82.

    Google Scholar 

  29. Finch TL, Rapley T, Girling M, Mair FS, Murray E, Treweek S, McColl E, Steen IN, May CR. Improving the normalization of complex interventions: measure development based on normalization process theory (NoMAD): study protocol. Implement Sci. 2013;8:43.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Flottorp SA, Oxman AD, Krause J, Musila NR, Wensing M, Godycki-Cwirko M, Baker R, Eccles MP. A checklist for identifying determinants of practice: a systematic review and synthesis of frameworks and taxonomies of factors that prevent or enable improvements in healthcare professional practice. Implement Sci. 2013;8:35.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Santesso N, Tugwell P. Knowledge translation in developing countries. J Contin Educ Heal Prof. 2006;26(1):87–96.

    Article  Google Scholar 

  32. World Health Organization. Global strategy on human resources for health: workforce 2030. Geneva: WHO; 2016.

    Google Scholar 

  33. De Neve JW, Garrison-Desany H, Andrews KG, Sharara N, Boudreaux C, Gill R, Geldsetzer P, Vaikath M, Bärnighausen T, Bossert TJ. Harmonization of community health worker programs for HIV: a four-country qualitative study in Southern Africa. PLoS Med. 2017;14(8):e1002374.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Kumar M, Nefdt R, Ribaira E, Diallo K. Access to healthcare through community health workers in East and Southern Africa. New York: UNICEF; 2014.

    Google Scholar 

  35. Tulenko K, Mogedal S, Afzal MM, Frymus D, Oshin A, Pate M, Quain E, Pinel A, Wynd S, Zodpey S. Community health workers for universal health-care coverage: from fragmentation to synergy. Bull World Health Organ. 2013;91(11):847–52.

    Article  PubMed  PubMed Central  Google Scholar 

  36. E-collection ‘RCTs - protocols/proposals (funded, already peer-reviewed, non-eHealth)’. http://www.researchprotocols.org/collection/view/242. Accessed 8 Aug 2018.

  37. E-collection ‘proposals (eHealth)’. http://www.researchprotocols.org/collection/view/84. Accessed 8 Aug 2018.

  38. Maher D, Cometto G. Research on community-based health workers is needed to achieve the sustainable development goals. Bull World Health Organ. 2016;94(11):786.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Pantoja T, Opiyo N, Lewin S, Paulsen E, Ciapponi A, Wiysonge CS, Herrera CA, Rada G, Peñaloza B, Dudley L, et al. Implementation strategies for health systems in low-income countries: an overview of systematic reviews. Cochrane Database Syst Rev. 2017;9:CD011086.

    PubMed  Google Scholar 

  40. Giguere A, Legare F, Grimshaw J, Turcotte S, Fiander M, Grudniewicz A, Makosso-Kallyth S, Wolf FM, Farmer AP, Gagnon MP. Printed educational materials: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012;10:CD004398.

    PubMed  Google Scholar 

  41. Cook DA, Levinson AJ, Garside S, Dupras DM, Erwin PJ, Montori VM. Internet-based learning in the health professions: a meta-analysis. J Am Med Assoc. 2008;300:1181–96.

    Article  CAS  Google Scholar 

  42. Forsetlund L, Bjorndal A, Rashidian A, Jamtvedt G, O'Brien MA, Wolf F, Davis D, Odgaard-Jensen J, Oxman AD. Continuing education meetings and workshops: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2009;2:CD003030.

    Google Scholar 

  43. Reeves S, Perrier L, Goldman J, Freeth D, Zwarenstein M. Interprofessional education: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2013;3:CD002213.

    Google Scholar 

  44. Horsley T, Hyde C, Santesso N, Parkes J, Milne R, Stewart R. Teaching critical appraisal skills in healthcare settings. Cochrane Database Syst Rev. 2011;11:CD001270.

    Google Scholar 

  45. Sunguya BF, Poudel KC, Mlunde LB, Shakya P, Urassa DP, Jimba M, Yasuoka J. Effectiveness of nutrition training of health workers toward improving caregivers’ feeding practices for children aged six months to two years: a systematic review. Nutr J. 2013;12:66.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Baskerville NB, Liddy C, Hogg W. Systematic review and meta-analysis of practice facilitation within primary care settings. Ann Fam Med. 2012;10(1):63–74.

    Article  PubMed  PubMed Central  Google Scholar 

  47. O'Brien MA, Rogers S, Jamtvedt G, Oxman AD, Odgaard-Jensen J, Kristoffersen DT, Forsetlund L, Bainbridge D, Freemantle N, Davis DA, et al. Educational outreach visits: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2007;4:CD000409.

    Google Scholar 

  48. Pande S, Hiller JE, Nkansah N, Bero L. The effect of pharmacist-provided non-dispensing services on patient outcomes, health service utilisation and costs in low- and middle-income countries. Cochrane Database Syst Rev. 2013;2:CD010398.

    Google Scholar 

  49. Flodgren G, Parmelli E, Doumit G, Gattellari M, O'Brien MA, Grimshaw J, Eccles MP. Local opinion leaders: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2011;8:CD000125.

    Google Scholar 

  50. Ivers N, Jamtvedt G, Flottorp S, Young JM, Odgaard-Jensen J, French SD, O'Brien MA, Johansen M, Grimshaw J, Oxman AD. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev. 2012, Issue 6. Art. No.: CD000259.

  51. Ko CH, Turner TJ, Finnigan M. Systematic review of safety checklists for use by medical care teams in acute hospital settings - limited evidence for effectiveness. BMC Health Serv Res. 2011;11:211.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, Robertson N, Wensing M, Fiander M, Eccles MP, et al. Tailored interventions to address determinants of practice. Cochrane Database Syst Rev. 2015;4:CD005470.

    Google Scholar 

  53. Perrier L, Mrklas K, Shepperd S, Dobbins M, McKibbon KA, Straus SE. Interventions encouraging the use of systematic reviews in clinical decision-making: a systematic review. J Gen Intern Med. 2011;26(4):419–26.

    Article  PubMed  Google Scholar 

  54. Nattrass N. AIDS and the scientific governance of medicine in post-apartheid South Africa. Afr Aff. 2008;107(427):157–76.

    Article  Google Scholar 

  55. Mackey TK, Liang BA. Combating healthcare corruption and fraud with improved global health governance. BMC Int Health Hum Rights. 2012;12:23.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Balabanova D, Mills A, Conteh L, Akkazieva B, Banteyerga H, Dash U, Gilson L, Harmer A, Ibraimova A, Islam Z, et al. Good health at low cost 25 years on: lessons for the future of health systems strengthening. Lancet. 2013;381(9883):2118–33.

    Article  PubMed  Google Scholar 

  57. Gibbert M, Hoegl M, Välikangas L. In praise of resource constraints. MIT Sloan Manag Rev. 2007;48(3):15.

    Google Scholar 

  58. Moreau C, Dahl D. Designing the solution: the impact of constraints on consumers’ creativity. J Consum Res. 2005;32:13–22.

    Article  Google Scholar 

  59. Sellier A, Dahl D. Focus! Creativity is enjoyed through restricted choice. J Mark Res. 2011;48(December):996–1007.

    Article  Google Scholar 

  60. Dahl D, Moreau C. Thinking inside the box: why consumers enjoy constrained creative experiences. J Mark Res. 2007;44(August):357–69.

    Article  Google Scholar 

  61. Grimsrud A, Sharp J, Kalombo C, Bekker L-G, Myer L. Implementation of community-based adherence clubs for stable antiretroviral therapy patients in Cape Town, South Africa. J Int AIDS Soc. 2015;18(1):19984.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Grimsrud A, Lesosky M, Kalombo C, Bekker LG, Myer L. Implementation and operational research: community-based adherence clubs for the management of stable antiretroviral therapy patients in Cape Town, South Africa: a cohort study. J Acquir Immune Defic Syndr. 2016;71(1):e16–23.

    PubMed  Google Scholar 

  63. Wilkinson LS. ART adherence clubs: a long-term retention strategy for clinically stable patients receiving antiretroviral therapy. South Afr J HIV Med. 2013;14(2):48.

    Article  Google Scholar 

  64. Tshuma N, Mosikare O, Yun JA, Alaba OA, Maheedhariah MS, Muloongo K, Nyasulu PS. Acceptability of community-based adherence clubs among health facility staff in South Africa: a qualitative study. Patient Prefer Adherence. 2017;11:1523–31.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Venables E, Edwards JK, Baert S, Etienne W, Khabala K, Bygrave H. “They just come, pick and go.” The acceptability of integrated medication adherence clubs for HIV and non communicable disease (NCD) patients in Kibera, Kenya. PLoS One. 2016;11(10):e0164634.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Decroo T, Koole O, Remartinez D, dos Santos N, Dezembro S, Jofrisse M, Rasschaert F, Biot M, Laga M. Four-year retention and risk factors for attrition among members of community ART groups in Tete, Mozambique. Tropical Med Int Health. 2014;19(5):514–21.

    Article  Google Scholar 

  67. Friends of the Global Fight against AIDS TaM. The case for U.S. investment in the Global Fund and Global Health. Washington, DC: theglobalfght.org; 2017.

    Google Scholar 

  68. McVeigh T. South Africa’s latest weapon against HIV: street dispensers for antiretrovirals. In: The Guardian; 2016.

    Google Scholar 

  69. Rosen JW. Zipline’s ambitious medical drone delivery in Africa. In: MIT technology review; 2017.

    Google Scholar 

  70. Gaffey C. Drones will fly HIV drugs and vaccines across Tanzania in biggest national delivery network. In: Newsweek; 2017.

    Google Scholar 

  71. Suwamaru JK. An SMS-based HIV/AIDS education and awareness model for rural areas in Papua New Guinea. Stud Health Technol Inform. 2012;182:161–9.

    PubMed  Google Scholar 

  72. Phillips KA, Epstein DH, Mezghanni M, Vahabzadeh M, Reamer D, Agage D, Preston KL. Smartphone delivery of mobile HIV risk reduction education. AIDS Res Treat. 2013;2013:231956.

    PubMed  PubMed Central  Google Scholar 

  73. Jennings L, Ong’ech J, Simiyu R, Sirengo M, Kassaye S. Exploring the use of mobile phone technology for the enhancement of the prevention of mother-to-child transmission of HIV program in Nyanza, Kenya: a qualitative study. BMC Public Health. 2013;13(1):1131.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Blaya JA, Fraser HS, Holt B. E-health technologies show promise in developing countries. Health Aff. 2010;29(2):244–51.

    Article  Google Scholar 

  75. Mars M. Building the capacity to build capacity in e-health in sub-Saharan Africa: the KwaZulu-Natal experience. Telemed J E Health. 2012;18(1):32–7.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Epstein D, Petersiel N, Klein E, Marcusohn E, Aviran E, Harel R, Azzam ZS, Neuberger A, Fuchs L. Pocket-size point-of-care ultrasound in rural Uganda - a unique opportunity “to see”, where no imaging facilities are available. Travel Med Infect Dis. 2018;23:87-93.

  77. Robbins RN, Gouse H, Brown HG, Ehlers A, Scott TM, Leu CS, Remien RH, Mellins CA, Joska JA. A mobile app to screen for neurocognitive impairment: preliminary validation of NeuroScreen among HIV-infected South African adults. JMIR mHealth uHealth. 2018;6(1):e5.

    Article  PubMed  PubMed Central  Google Scholar 

  78. van Heerden A, Sen D, Desmond C, Louw J, Richter L. App-supported promotion of child growth and development by community health workers in Kenya: feasibility and acceptability study. JMIR mHealth uHealth. 2017;5(12):e182.

    Article  PubMed  PubMed Central  Google Scholar 

  79. Bardosh KL, Murray M, Khaemba AM, Smillie K, Lester R. Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya. Glob Health. 2017;13(1):87.

    Article  Google Scholar 

  80. Mars M. Telemedicine and advances in urban and rural healthcare delivery in Africa. Prog Cardiovasc Dis. 2013;56(3):326–35.

    Article  PubMed  Google Scholar 

  81. Govindarajan V, Trimble C. Reverse innovation: create far from home, win everywhere. Boston: Harvard Business Review Press; 2010.

    Google Scholar 

  82. Bhatti Y, Taylor A, Harris M, Wadge H, Escobar E, Prime M, Patel H, Carter AW, Parston G, Darzi AW, et al. Global lessons in frugal innovation to improve health care delivery in the United States. Health Aff. 2017;36(11):1912–9.

    Article  Google Scholar 

  83. Syed SB, Dadwal V, Rutter P, Storr J, Hightower JD, Gooden R, Carlet J, Nejad SB, Kelley ET, Donaldson L, et al. Developed-developing country partnerships: benefits to developed countries? Glob Health. 2012;8(1):17.

    Article  Google Scholar 

  84. The Gambia Hepatits Study Group. The Gambia Hepatitis Intervention Study. Cancer Res. 1987;47:5782–7.

    Google Scholar 

  85. Canning D, Shah IH, Pearson E, Pradhan E, Karra M, Senderowicz L, Bärnighausen T, Spiegelman D, Langer A. Institutionalizing postpartum intrauterine device (IUD) services in Sri Lanka, Tanzania, and Nepal: study protocol for a cluster-randomized stepped-wedge trial. BMC Pregnancy Childbirth. 2016;16(1):362.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Fink G, Robyn PJ, Sie A, Sauerborn R. Does health insurance improve health?: evidence from a randomized community-based insurance rollout in rural Burkina Faso. J Health Econ. 2013;32(6):1043–56.

    Article  PubMed  Google Scholar 

  87. Walsh FJ, Bärnighausen T, Delva W, Fleming Y, Khumalo G, Lejeune CL, Mazibuko S, Mlambo CK, Reis R, Spiegelman D, et al. Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system: study protocol for a stepped-wedge randomized trial. Trials. 2017;18(1):383.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Pfeiffer JT, Napua M, Wagenaar BH, Chale F, Hoek R, Micek M, Manuel J, Michel C, Cowan JG, Cowan JF, et al. Stepped-wedge cluster randomized controlled trial to promote option B+ retention in Central Mozambique. J Acquir Immune Defic Syndr. 2017;76(3):273–80.

    Article  PubMed  Google Scholar 

  89. Praveen D, Patel A, McMahon S, Prabhakaran D, Clifford GD, Maulik PK, Joshi R, Jan S, Heritier S, Peiris D. A multifaceted strategy using mobile technology to assist rural primary healthcare doctors and frontline health workers in cardiovascular disease risk management: protocol for the SMARTHealth India cluster randomised controlled trial. Implement Sci. 2013;8:137.

    Article  PubMed  PubMed Central  Google Scholar 

  90. McGuinness SL, O'Toole JE, Boving TB, Forbes AB, Sinclair M, Gautam SK, Leder K. Protocol for a cluster randomised stepped wedge trial assessing the impact of a community-level hygiene intervention and a water intervention using riverbank filtration technology on diarrhoeal prevalence in India. BMJ Open. 2017;7(3):e015036.

    Article  PubMed  PubMed Central  Google Scholar 

  91. World Bank. World development indicators. Washington, DC: World Bank; 2017.

    Google Scholar 

  92. Tomlinson M, Solomon W, Singh Y, Doherty T, Chopra M, Ijumba P, Tsai AC, Jackson D. The use of mobile phones as a data collection tool: a report from a household survey in South Africa. BMC Med Inform Decis Mak. 2009;9(1):51.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Soti DO, Kinoti SN, Omar AH, Logedi J, Mwendwa TK, Hirji Z, Ferro S. Feasibility of an innovative electronic mobile system to assist health workers to collect accurate, complete and timely data in a malaria control programme in a remote setting in Kenya. Malar J. 2015;14:430.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  94. African Development Bank Group. Innovative e-Health solutions in Africa award. Abidjan: African Development Bank; 2014.

  95. Bärnighausen T, Eyal N, Wikler D. HIV treatment-as-prevention research at a crossroads. PLoS Med. 2014;11(6):e1001654.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Bor J, Fox MP, Rosen S, Venkataramani A, Tanser F, Pillay D, Bärnighausen T. Treatment eligibility and retention in clinical HIV care: a regression discontinuity study in South Africa. PLoS Med. 2017;14(11):e1002463.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Brennan AT, Bor J, Davies MA, Wandeler G, Prozesky H, Fatti G, Wood R, Stinson K, Tanser F, Bärnighausen T, et al. Drug side effects and retention on HIV treatment: a regression discontinuity study of tenofovir implementation in South Africa and Zambia. Am J Epidemiol. 2018;187(9):1990-2001.

  98. Tatah L, Delbiso TD, Rodriguez-Llanes JM, Gil Cuesta J, Guha-Sapir D. Impact of refugees on local health systems: a difference-in-differences analysis in Cameroon. PLoS One. 2016;11(12):e0168820.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  99. McGovern ME, Herbst K, Tanser F, Mutevedzi T, Canning D, Gareta D, Pillay D, Bärnighausen T. Do gifts increase consent to home-based HIV testing? A difference-in-differences study in rural KwaZulu-Natal, South Africa. Int J Epidemiol. 2016;45(6):2100–9.

    PubMed  PubMed Central  Google Scholar 

  100. Bärnighausen T, Rottingen JA, Rockers P, Shemilt I, Tugwell P. Quasi-experimental study designs series-paper 1: introduction: two historical lineages. J Clin Epidemiol. 2017;89:4–11.

    Article  PubMed  Google Scholar 

  101. Gertler PJ, Martinez S, Premand P, Rawlings LB, Vermeersch C. Impact evaluation in practice. Washington, DC: The World Bank; 2011.

    Google Scholar 

  102. European Commission. Social policy experiments in the European Union: examples in member states. Brussels: European Commission; 2011.

    Google Scholar 

  103. Trans-NIH Programs. https://www.fic.nih.gov/Funding/Pages/Collaborations.aspx. Accessed 8 Aug 2018.

  104. WHO TDR. Progress report on the TDR postgraduate training scheme during the period May 2015 - May 2017. Geneva: WHO TDR. p. 2017.

  105. McKee M, Stuckler D, Basu S. Where there is no health research: what can be done to fill the global gaps in health research. PLoS Med. 2012;9(4):e1001209.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Schwartz JI, Dunkle A, Akiteng AR, Birabwa-Male D, Kagimu R, Mondo CK, Mutungi G, Rabin TL, Skonieczny M, Sykes J, et al. Towards reframing health service delivery in Uganda: the Uganda initiative for integrated management of non-communicable diseases. Glob Health Action. 2015;8:26537.

    Article  PubMed  Google Scholar 

  107. Chanda-Kapata P, Ngosa W, Hamainza B, Kapiriri L. Health research priority setting in Zambia: a stock taking of approaches conducted from 1998 to 2015. Health Res Policy Syst. 2016;14(1):72.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Lobb R, Colditz GA. Implementation science and its application to population health. Annu Rev Public Health. 2013;34:235–51.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Ongoing and planned PrEP demonstration and implementation studies. https://www.avac.org/resource/ongoing-and-planned-prep-demonstration-and-implementation-studies. Accessed 8 Aug 2018.

  110. Cowan FM, Delany-Moretlwe S, Sanders EJ, Mugo NR, Guedou FA, Alary M, Behanzin L, Mugurungi O, Bekker LG. PrEP implementation research in Africa: what is new? J Int AIDS Soc. 2016;19(7(Suppl 6)):21101.

    PubMed  PubMed Central  Google Scholar 

  111. Geldsetzer P, Bärnighausen T. Late-stage research for diabetes and related NCDs receives little funding: evidence from the NIH RePORTER tool. Lancet Diabetes Endocrinol. 2017;5(2):91–2.

    Article  PubMed  Google Scholar 

  112. Jain A, Agarwal R, Chawla D, Paul V, Deorari A. Tele-education vs classroom training of neonatal resuscitation: a randomized trial. J Perinatol: official journal of the California Perinatal Association. 2010;30(12):773–9.

    Article  CAS  Google Scholar 

  113. Patel SN, Martinez-Castellanos MA, Berrones-Medina D, Swan R, Ryan MC, Jonas KE, Ostmo S, Campbell JP, Chiang MF, Chan RVP. Assessment of a tele-education system to enhance retinopathy of prematurity training by international ophthalmologists-in-training in Mexico. Ophthalmology. 2017;124(7):953–61.

    Article  PubMed  Google Scholar 

  114. Joshi A, Novaes MA, Iyengar S, Machiavelli JL, Zhang J, Vogler R, Hsu CE. Evaluation of a tele-education programme in Brazil. J Telemed Telecare. 2011;17(7):341–5.

    Article  PubMed  Google Scholar 

  115. Pradeep PV, Mishra A, Mohanty BN, Mohapatra KC, Agarwal G, Mishra SK. Reinforcement of endocrine surgery training: impact of telemedicine technology in a developing country context. World J Surg. 2007;31(8):1665–71.

    Article  CAS  PubMed  Google Scholar 

  116. Chao LW, Cestari TF, Bakos L, Oliveira MR, Miot HA, Zampese M, Andrade CB, Bohm GM. Evaluation of an internet-based teledermatology system. J Telemed Telecare. 2003;9(Suppl 1):S9–12.

    Article  PubMed  Google Scholar 

  117. Moughrabieh A, Weinert C. Rapid deployment of international tele-intensive care unit services in war-torn Syria. Ann Am Thorac Soc. 2016;13(2):165–72.

    Article  PubMed  PubMed Central  Google Scholar 

  118. Fairall L, Bachmann MO, Lombard C, Timmerman V, Uebel K, Zwarenstein M, Boulle A, Georgeu D, Colvin CJ, Lewin S, et al. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet. 2012;380(9845):889–98.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Maulik PK, Kallakuri S, Devarapalli S, Vadlamani VK, Jha V, Patel A. Increasing use of mental health services in remote areas using mobile technology: a pre-post evaluation of the SMART mental health project in rural India. J Glob Health. 2017;7(1):010408.

    Article  PubMed  PubMed Central  Google Scholar 

  120. Ogedegbe G, Plange-Rhule J, Gyamfi J, Chaplin W, Ntim M, Apusiga K, Khurshid K, Cooper R. A cluster-randomized trial of task shifting and blood pressure control in Ghana: study protocol. Implement Sci. 2014;9:73.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Ahmed S, Kim MH, Dave AC, Sabelli R, Kanjelo K, Preidis GA, Giordano TP, Chiao E, Hosseinipour M, Kazembe PN, et al. Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi. J Int AIDS Soc. 2015;18:19305.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Geldsetzer P, Francis JM, Ulenga N, Sando D, Lema IA, Mboggo E, Vaikath M, Koda H, Lwezaula S, Hu J, et al. The impact of community health worker-led home delivery of antiretroviral therapy on virological suppression: a non-inferiority cluster-randomized health systems trial in Dar es Salaam, Tanzania. BMC Health Serv Res. 2017;17(1):160.

    Article  PubMed  PubMed Central  Google Scholar 

  123. Jennings L, Yebadokpo AS, Affo J, Agbogbe M, Tankoano A. Task shifting in maternal and newborn care: a non-inferiority study examining delegation of antenatal counseling to lay nurse aides supported by job aids in Benin. Implement Sci. 2011;6:2.

    Article  PubMed  PubMed Central  Google Scholar 

  124. MacPherson P, Lalloo DG, Webb EL, Maheswaran H, Choko AT, Makombe SD, Butterworth AE, van Oosterhout JJ, Desmond N, Thindwa D, et al. Effect of optional home initiation of HIV care following HIV self-testing on antiretroviral therapy initiation among adults in Malawi: a randomized clinical trial. J Am Med Assoc. 2014;312(4):372–9.

  125. Ortblad K, Kibuuka Musoke D, Ngabirano T, Nakitende A, Magoola J, Kayiira P, Taasi G, Barresi LG, Haberer JE, McConnell MA, et al. Direct provision versus facility collection of HIV self-tests among female sex workers in Uganda: a cluster-randomized controlled health systems trial. PLoS Med. 2017;14(11):e1002458.

    Article  PubMed  PubMed Central  Google Scholar 

  126. Chanda MM, Ortblad KF, Mwale M, Chongo S, Kanchele C, Kamungoma N, Fullem A, Dunn C, Barresi LG, Harling G, et al. HIV self-testing among female sex workers in Zambia: a cluster randomized controlled trial. PLoS Med. 2017;14(11):e1002442.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Asiimwe S, Oloya J, Song X, Whalen CC. Accuracy of un-supervised versus provider-supervised self-administered HIV testing in Uganda: a randomized implementation trial. AIDS Behav. 2014;18(12):2477–84.

    Article  PubMed  PubMed Central  Google Scholar 

  128. Jeronimo J, Bansil P, Lim J, Peck R, Paul P, Amador JJ, Mirembe F, Byamugisha J, Poli UR, Satyanarayana L, et al. A multicountry evaluation of careHPV testing, visual inspection with acetic acid, and papanicolaou testing for the detection of cervical cancer. Int J Gynecol Cancer. 2014;24(3):576–85.

    Article  PubMed  PubMed Central  Google Scholar 

  129. Awah PK, Boock AU, Mou F, Koin JT, Anye EM, Noumen D, Nichter M. Developing a Buruli ulcer community of practice in Bankim, Cameroon: a model for Buruli ulcer outreach in Africa. PLoS Negl Trop Dis. 2018;12(3):e0006238.

    Article  PubMed  PubMed Central  Google Scholar 

  130. Rocha R, Soares RR. Evaluating the impact of community-based health interventions: evidence from Brazil’s family health program. Health Econ. 2010;19(Suppl):126–58.

    Article  PubMed  Google Scholar 

  131. Odeny TA, Bukusi EA, Cohen CR, Yuhas K, Camlin CS, McClelland RS. Texting improves testing: a randomized trial of two-way SMS to increase postpartum prevention of mother-to-child transmission retention and infant HIV testing. AIDS. 2014;28(15):2307–12.

  132. Piette JD, Datwani H, Gaudioso S, Foster SM, Westphal J, Perry W, Rodriguez-Saldana J, Mendoza-Avelares MO, Marinec N. Hypertension management using mobile technology and home blood pressure monitoring: results of a randomized trial in two low/middle-income countries. Telemed J E Health. 2012;18(8):613–20.

    Article  PubMed  PubMed Central  Google Scholar 

  133. Bobrow K, Farmer AJ, Springer D, Shanyinde M, Yu LM, Brennan T, Rayner B, Namane M, Steyn K, Tarassenko L, et al. Mobile phone text messages to support treatment adherence in adults with high blood pressure (SMS-Text Adherence Support [StAR]): a single-blind, randomized trial. Circulation. 2016;133(6):592–600.

    PubMed  PubMed Central  Google Scholar 

  134. Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, Jack W, Habyarimana J, Sadatsafavi M, Najafzadeh M, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838–45.

    Article  PubMed  Google Scholar 

  135. Jani IV, Meggi B, Vubil A, Sitoe NE, Bhatt N, Tobaiwa O, Quevedo JI, Loquiha O, Lehe JD, Vojnov L, et al. Evaluation of the whole-blood Alere Q NAT point-of-care RNA assay for HIV-1 viral load monitoring in a primary health care setting in Mozambique. J Clin Microbiol. 2016;54(8):2104–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  136. Mtapuri-Zinyowera S, Chideme M, Mangwanya D, Mugurungi O, Gudukeya S, Hatzold K, Mangwiro A, Bhattacharya G, Lehe J, Peter T. Evaluation of the PIMA point-of-care CD4 analyzer in VCT clinics in Zimbabwe. J Acquir Immune Defic Syndr. 2010;55(1):1–7.

    Article  PubMed  Google Scholar 

  137. Jani IV, Sitoe NE, Alfai ER, Chongo PL, Quevedo JI, Rocha BM, Lehe JD, Peter TF. Effect of point-of-care CD4 cell count tests on retention of patients and rates of antiretroviral therapy initiation in primary health clinics: an observational cohort study. Lancet. 2011;378(9802):1572–9.

    Article  PubMed  Google Scholar 

  138. Theron G, Zijenah L, Chanda D, Clowes P, Rachow A, Lesosky M, Bara W, Mungofa S, Pai M, Hoelscher M, et al. Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial. Lancet. 2014;383(9915):424–35.

    Article  CAS  PubMed  Google Scholar 

  139. Somashekhar S, Vijay R, Ananthasivan R, Prasanna G. Noninvasive and low-cost technique for early detection of clinically relevant breast lesions using a handheld point-of-care medical device (iBreastExam): prospective three-arm triple-blinded comparative study. Indian J Gynecol Oncol. 2016;13:26.

    Article  Google Scholar 

  140. Dahinten AP, Dow DE, Cunningham CK, Msuya LJ, Mmbaga BT, Malkin RA. Providing safe and effective preventative antiretroviral prophylaxis to HIV-exposed newborns via a novel drug delivery system in Tanzania. Pediatr Infect Dis J. 2016;35(9):987–91.

    Article  PubMed  PubMed Central  Google Scholar 

  141. Rutta E, Kibassa B, McKinnon B, Liana J, Mbwasi R, Mlaki W, Embrey M, Gabra M, Shekalaghe E, Kimatta S, et al. Increasing access to subsidized artemisinin-based combination therapy through accredited drug dispensing outlets in Tanzania. Health Res Policy Syst. 2011;9:22.

    Article  PubMed  PubMed Central  Google Scholar 

  142. Berry J, Berry S, Ramchandani R. Colalife operational trial Zambia (COTZ) -- improving use, access, availability and awareness of ORS and zinc for the treatment of diarrhoea in the home: endline survey report. Lusaka: RuralNet Associates Ltd; 2014.

    Google Scholar 

  143. Molemodile S, Wotogbe M, Abimbola S. Evaluation of a pilot intervention to redesign the decentralised vaccine supply chain system in Nigeria. Glob Public Health. 2017;12(5):601–16.

    Article  PubMed  Google Scholar 

  144. Mehta KM, Rerolle F, Rammohan SV, Albohm DC, Muwowo G, Moseson H, Sept L, Lee HL, Bendavid E. Systematic motorcycle management and health care delivery: a field trial. Am J Public Health. 2016;106(1):87–94.

    Article  PubMed  PubMed Central  Google Scholar