Institutional Biosafety Committee | Division of Research Safety | Illinois

Institutional Biosafety Committee | Division of Research Safety | Illinois
Membership & Minutes
Materials Requiring Registration
Poliovirus Containment Initiative
Gene Drive Modified Organisms
Registration, Projects and Numbering
Tips for Completing/Managing Registrations
Submission Deadlines/Meeting Schedule
Review Process
IBC Approval
Required Training
References
Membership & Minutes
The Institutional Biosafety Committee (IBC) works to protect the health and safety of faculty, staff, students, and the public from potential hazards associated with the use of biological materials and organisms in research or teaching, and to ensure the University of Illinois Urbana-Champaign complies with all applicable federal, state, and local regulations. The committee reports to the Vice Chancellor of Research and Innovation and is co-chaired by
Romana Nowak
and
Mary Kraft
. Questions? email ibc@illinois.edu or call 217.333.2755.
IBC Roster and Minutes
If you have questions when using the system please email
ibc@illinois.edu
. For IT assistance or to report issues with the system email
drs-dev@illinois.edu
Enter Registration System
Materials Requiring Registration
All work with materials requiring registration must be approved by the IBC prior to initiation.
The following materials require registration with the IBC:
Recombinant or synthetic nucleic acid molecules (even work that is exempt from the NIH guidelines must be registered*);
Transgenic animals (use or creation);
Transgenic plants;
Pathogens (human, animal, or plant);
Human materials (cell lines; blood, blood products, tissues, any bodily fluid);
Nonhuman primate (NHP) materials (cell lines, blood, blood products, tissues, any bodily fluid);
Biotoxins
Prions
Environmental or field collected samples that harbor or may harbor pathogens (e.g., wastewater, soil, wild animal materials)
The university is responsible for ensuring that all recombinant or synthetic nucleic acid research, irrespective of funding source, is conducted "in full conformity with the provisions of the NIH Guidelines." To ensure compliance with the guidelines, campus policy requires that all recombinant or synthetic nucleic acid work must be registered with the IBC. Work cannot begin on projects involving recombinant or synthetic nucleic acids until the Principal Investigator (PI) receives a notice from the Division of Research Safety and/or the IBC allowing the initiation of work. NIH penalties for university/PI noncompliance may result in: (i) suspension, limitation, or termination of NIH funds for recombinant or synthetic nucleic acid research at the university, or (ii) a requirement for prior NIH approval of any or all recombinant or synthetic nucleic acid projects at the university.
Poliovirus Containment Initiative
Polio remains endemic in two countries resulting in outbreaks around the world. The
U.S. National Authority for Containment of Poliovirus (NAC)
at the Centers for Disease Control and Prevention (CDC) launched a surveillance program aimed to minimize the risk of poliovirus release from research and diagnostic laboratories. As part of this program,  the Institutional Biosafety Committee (IBC) added screening questions to the registration process to identify materials which contain or may contain poliovirus according to the criteria established in the WHO Global Action Plan (
GAPIV
). For more information, visit the DRS
Poliovirus Containment Initiative
webpage.
Gene Drive Modified Organisms
In April 2024, the NIH Guidelines added a new section III D-8 to cover experiments that involve gene drive modified organisms generated by recombinant or synthetic nucleic acid molecules. These experiments will be conducted at a minimum of Biosafety Level 2 (BL-2), Animal Biosafety Level 2 (ABL-2), Plant Biosafety Level 2 (PBL-2), or Arthropod Containment Level 2 (ACL-2) containment. For additional guidance from the NIH visit;
Biosafety Considerations for Contained Research Involving Gene Drive Modified Organisms
Registration, Projects and Numbering
All materials, facilities and personnel are found at the registration level and must be assigned to an individual project, even if you only have one project. Individual projects under that registration are submitted for review and receive approval dates.
Each PI will be assigned one IBC registration number that will not change. Projects are identified by a period after the registration number. For example, If a PI is given a registration number of IBC-555 then the first project submitted for review will be IBC-555.1.  As additional projects are added, they will be numbered in sequential order e.g., IBC-555.1, IBC-555.2, IBC-555.3.  If IBC-555.2 is completed, this number will not be reused and the next project will be numbered IBC-555.4.
Tips for Completing/Managing Registrations
Provide enough detail to allow IBC reviewers to understand the risk elements in the context of the research so they can verify that the proposed safety measures are sufficient.
Focus the project on the material(s) that require registration, state where the materials will be used, the manipulations being performed, inactivation steps that may change containment, safety measures or equipment (e.g., biosafety cabinet) used to mitigate risks, and decontamination and disposal procedures.
Be aware of the IBC meeting and submission schedule to ensure ample time for the review and approval of your registration.
It's allowable to have one IBC project that covers work described in multiple protocols from the Institutional Animal Care and Use Committee (IACUC) and/or the Institutional Review Board (IRB).
For IBCs that involve animal work, the associated IACUC and IBC must be in the same PIs name.
All work that requires registration may be included in one IBC project if the work can be explained clearly. In some cases, it may be easier to separate into multiple projects if the focus is significantly different.
All laboratory personnel may initiate, complete, or update a project on behalf of the PI.
In the context of an IBC registration, someone may be considered as the PI if they have the responsibility and authority for the research or teaching activities being conducted, and for the staff and students participating in the work. This level of control and responsibility typically falls to a faculty member who reports directly to a Department or Unit Head. There are occasional exceptions when someone other than a faculty member has the required authority.
All project personnel, including the PI, are required to complete safety training.
Projects should be updated whenever there are changes in personnel, facilities, or experimental protocols/materials or at minimum on an annual basis.
Submission Deadlines/Meeting Schedule
The IBC meets once per month as per the following schedule. Complete project information must be submitted by 5 p.m. on the submission deadline date before the meeting at which your project will be reviewed.
Submission Deadline
IBC Meeting
January 16, 2026
February 10, 2026
February 13, 2026
March 10, 2026
March 20, 2026
April 14, 2026
April 17, 2026
May 12, 2026
May 15, 2026
June 9, 2026
June 19, 2026
July 14, 2026
July 17, 2026
August 11, 2026
August 14, 2026
September 8, 2026
Review Process
Once a project is submitted for review, you will receive an email confirming receipt. In most cases,* the project will be assigned to a panel of faculty reviewers who will review the project to verify your risk assessment for the proposed work. Once submitted for review, the project will be locked.   The next step is the question and answer period where the reviewers will ask questions directly in the project. When the review period is complete, the PI and the personnel on the project will be notified via email that their responses to questions are due by a specific date for before the upcoming IBC meeting. Simultaneously, the DRS research safety professional overseeing the project review will determine if any BL-2 or ABL-2 audits are required. All rooms where work will be performed at Biosafety Level 2 or Animal Biosafety Level 2 must be audited before work can begin in that space and will be audited annually thereafter through the laboratory audit program.
Approvals will not be issued until all questions and audit findings have been addressed and all required training completed.
*Some lower risk projects (e.g., Recombinant DNA projects requiring Biosafety Level 1 containment) may qualify for review by a DRS research safety professional. In these situations, the review process may be expedited. However, the best approach is to plan for the timeline outlined above and in the Submission Deadline/Meeting Schedule section.
IBC Approval
An IBC project is valid for 5 years.  DRS will send reminders to review and update if no changes have been made for 12 months. Major updates/amendments may require to be re-reviewed by the IBC however the approval date will not change.
Required Training
Required Training for work with recombinant or synthetic nucleic acids
NIH requires training when performing experiments with recombinant or synthetic nucleic acids including transgenic plants and animals (including knockouts). This training requirement will be met by completion of the
NIH Guidelines Overview
module.
Required Training for work at Biosafety Level 1
Basic training requirements for all laboratories are outlined on the
Safety Training Checklis
webpage as part of a required
Laboratory Safety Plan
This includes the on-line training module
Laboratory Safety
Required Training for work at Biosafety Level 2
Additional training and information specific to work at Biosafety level 2 should include:
Review of laboratory biosafety level criteria as outlined in the
Biosafety in Microbiological and Biomedical Laboratories (BMBL) 6th Edition
Completion of the DRS course
Understanding Biosafety
The
Biosafety Level 2 Guide
supplements the
Laboratory Safety Guide/Chemical Hygiene Plan
for your Lab Safety Plan.
Review of
Storage of Risk Group 2 Biological Materials
guidance document
Review of
Biological Material Transport
webpage and completion of additional transportation training as required
Personnel working with human materials must also a
ttend the
Safe Handling of Human Cell Lines/Materials in a Research Laboratory
course once and then repeat the on-line refresher training annually and review the
University of Illinois at Urbana-Champaign Bloodborne Pathogen Exposure Control Plan
Review of the following DRS Guidance documents for all equipment being used in the laboratory:
Biological Safety Cabinets
Protecting Vacuum Lines From Biohazards
Autoclave Safety and Operation
Biological Samples Stored in Liquid Nitrogen
Review of the following DRS Guidance documents for all applicable waste generated in the laboratory:
User Treatment of Biological Waste
Laboratory Sharps
Autoclave - Waste and Validation
Biological Materials Requiring Incineration
Biotoxin Treatment & Disposal
Laboratory-Specific Training
Review of IBC project registration information that outlines laboratory and experiment-specific safety procedures and requirements.
Review of laboratory-specific policies developed by the laboratory group that outlines how certain Biosafety Level 2 requirements will be implemented within the laboratory group and associated facilities.
Review of all applicable Standard Operating Procedures (see
Standard Operating Procedures
webpage for information on SOP development).
Dual Use Research of Concern (DURC)
On May 5, 202
, an
Executive Order
on Improving the Safety of Biological Research was issued which pauses the 2024 DURC-PEPP policy that was to be implemented on May 6, 2025.  The Director of the Office of Science and Technology Policy (OSTP) and the National Security Advisor will work with funding agencies to develop a new policy within 120 days to replace the
2024 DURC-PEPP policy
. In the interim, previous USC DURC policies and HHH P3CO Framework remain in place. Updates will be made as they are announced.
Dual Use Research of Concern (DURC) is life sciences research that, based on current understanding, can be reasonably anticipated to provide knowledge, information, products, or technologies that could be misapplied to do harm with no, or only minor, modification to pose a significant threat with potential consequences to public health and safety, agricultural crops and other plants, animals, the environment, materiel, or national security.
Pathogen with Enhanced Pandemic Potential (PEPP) is a type of pathogen with pandemic potential (PPP) resulting from experiments that enhance a pathogen’s transmissibility or virulence, or disrupt the effectiveness of pre-existing immunity, regardless of its progenitor agent, such that it may pose a significant threat to public health, the capacity of health systems to function, or national security. Wild-type pathogens that are circulating in or have been recovered from nature are not PEPPs but may be considered PPPs because of their pandemic potential.
On May 6, 2024, the United States Government (USG) released a
new policy
and
implementation guidance
for research involving DURC-PEPP. This policy supersedes previous
2012
and
2014
USG DURC policies and the
2017
HHS Framework for Guiding Funding Decisions about Proposed Research Involving Enhanced Potential Pandemic Pathogens (HHS P3CO Framework) beginning May 6, 2025.
The 2012 and 2014 USG DURC policies outlines the criteria for what qualifies as DURC. A list of the 15 agents and toxins and descriptions of the 7 experimental effects for potential DURC research can be found on the
DURC Agent and Experiment Effect List
To better understand the DURC requirements and when research meets the DURC criteria, the NIH-Office of Sciences Policy provides an overview and case study approach for research that requires oversight of life sciences DURC.
A one time online training entitled
DURC Policy Overview
is required to be taken by the following campus personnel;
All PIs, staff, and students whose research uses any of the agents or toxins subject to the policy.
IBC members.
Administrative staff supporting the IBC.
Review of Potential DURC Projects
To comply with the US government DURC policy, a campus Institutional Review Entity (IRE) has been established to review research for DURC which is coordinated through the IBC.
It is the responsibility of the Principal Investigator to identify research involving one or more of the agents and toxins on the DURC list and notify the IRE-IBC for review of its DURC potential. The formal review starts with the PI submission of the DURC Review Application which is submitted to
ibc@illinois.edu
in conjunction with the IBC registration to determine whether or not the project meets the DURC definition. For research that is determined to be DURC, a subcommittee will work with the PI to draft a risk mitigation plan to be submitted to the applicable US government funding agency.
DURC Review Application Form
References
NIH Guidelines
Biosafety in Microbiological and Biomedical Laboratories (BMBL 6th Edition)
1/14/2026
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