Jayanta Debnath | UCSF Profiles

Microautophagy: current understanding of its molecular mechanisms and functions. Autophagy Rep. 2026; 5(1):2626661. Sakai Y, Behrends C, Debnath J, Izumi M, Jenny A, Molinari M, Nakamura S, Oku M, Otegui MS, Santambrogio L, Shen HM, Taguchi T, Thumm M, Ushimaru T, Xie Z, Cuervo AM, Reggiori F. PMID: 41756808; PMCID: PMC12934144.

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Endothelial Cell Autophagy Suppresses Metastasis In Mouse Mammary and Pancreatic Neuroendocrine Tumor Models. bioRxiv. 2026 Jan 29. León-Rivera N, Chin B, Quintana A, Bustamante-Eguíguren S, Gacasan A, Nanni M, Debnath J, Monkkonen T. PMID: 41659580; PMCID: PMC12873938.

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Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks. Cell Rep. 2025 Nov 25; 44(11):116494. Smeyers J, Oses-Prieto JA, Yadanar L, Wang M, Iadarola M, Lu S, Wang KS, Watanabe TH, Debnath J, Burlingame AL, Mordes DA. PMID: 41171761; PMCID: PMC12967247.

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Autophagy-dependent proteostasis suppresses breast cancer metastasis. Autophagy. 2025 Dec; 21(12):3428-3429. Debnath J, Mondal G. PMID: 41037800; PMCID: PMC12758352.

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Beyond the Secretory Pathway: New Insights Into Protein Release. Traffic. 2025 Oct; 26(10-12):e70022. Chen RH, Costa-Filho AJ, Debnath J, Galli T, Ge L, Goberdhan D, Guo W, He K, Jacob R, Kang T, Lee MG, Li L, Lolicato F, Lu J, Malhotra V, Nickel W, Nikoletopoulou V, Ogden SK, Sagia GM, Shao F, Shi A, Thery C, Vérollet C, Villeneuve J, Verweij F, Wang Y, Wang J, Wu S, Ye Y, Yin H, Yu L, Zhang M, Zhang Y, Zhou X, Zurzolo C. PMID: 41195561; PMCID: PMC12590341.

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Microautophagy: definition, classification, and the complexity of the underlying mechanisms. Autophagy. 2026 Jan; 22(1):3-9. Sakai Y, Behrends C, Cuervo AM, Debnath J, Izumi M, Jenny A, Molinari M, Nakamura S, Oku M, Otegui MS, Santambrogio L, Shen HM, Taguchi T, Thumm M, Ushimaru T, Xie Z, Reggiori F. PMID: 40928057; PMCID: PMC12758294.

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Autophagy-targeted NBR1-p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH. Nat Cell Biol. 2025 Jul; 27(7):1098-1113. Mondal G, Gonzalez H, Marsh T, Leidal AM, Vlahakis A, Phadatare PR, Bustamante Eguiguren S, Bruck M, Naik A, Magbanua MJM, Huppert LA, Wiita AP, Roose JP, Rosenbluth JM, Debnath J. PMID: 40579454; PMCID: PMC12740005.

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4  

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HumansAnimalsCells

Lysosomal lipid peroxidation mediates immunogenic cell death. J Clin Invest. 2023 04 17; 133(8). Phadatare P, Debnath J. PMID: 37066873; PMCID: PMC10104885.

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7  

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HumansCells

Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023 08; 24(8):560-575. Debnath J, Gammoh N, Ryan KM. PMID: 36864290; PMCID: PMC9980873.

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627  

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HumansCells

Where is the field of autophagy research heading? Autophagy. 2023 04; 19(4):1049-1054. Abeliovich H, Debnath J, Ding WX, Jackson WT, Kim DH, Klionsky DJ, Ktistakis N, Margeta M, Münz C, Petersen M, Sadoshima J, Vergne I. PMID: 36628432; PMCID: PMC10012950.

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5  

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LC3-dependent EV loading and secretion (LDELS) promotes TFRC (transferrin receptor) secretion via extracellular vesicles. Autophagy. 2023 05; 19(5):1551-1561. Gardner JO, Leidal AM, Nguyen TA, Debnath J. PMID: 36286616; PMCID: PMC10240981.

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14  

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Cells

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Secretory autophagy during lysosome inhibition (SALI). Autophagy. 2022 10; 18(10):2498-2499. Debnath J, Leidal AM. PMID: 35786367; PMCID: PMC9542525.

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15  

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Cells

Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival. Proc Natl Acad Sci U S A. 2022 05 24; 119(21):e2202016119. Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E. PMID: 35537042; PMCID: PMC9173755.

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PubMed

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11  

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AnimalsCells

Secretory autophagy maintains proteostasis upon lysosome inhibition. J Cell Biol. 2022 06 06; 221(6). Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J, Leidal AM. PMID: 35446347; PMCID: PMC9036093.

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90  

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HumansCells

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Development and On-Field Deployment of a Mobile-Based Application 'MoSQuIT' for Malaria Surveillance in International Border Districts of Northeast India-Challenges and Opportunities. Int J Environ Res Public Health. 2022 02 23; 19(5). Patgiri SJ, Gohain GG, Goswami SK, Bhattacharyya DR, Debnath SHD, Panat L, Karajkhede G, Mohapatra PK, Sarma DK, Bhowmick IP, Gogoi K, Biswas S, Debnath J, Acharjee S, Senapati S, Neog R, Nath P, Meitei K, Baidya S, Debbarma D, Sarma A, Ahmed RA, Boro H, Das RC, Mahanta J, Debbarma SR, Kaur H. PMID: 35270256; PMCID: PMC8909168.

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2  

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Humans

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2  

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Humans

GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Biol Open. 2021 10 15; 10(10). Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. PMID: 34533192; PMCID: PMC8524720.

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6  

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HumansCells

Autophagy in host stromal fibroblasts supports tumor desmoplasia. Autophagy. 2021 12; 17(12):4497-4498. Rudnick JA, Debnath J. PMID: 34470579; PMCID: PMC8726599.

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PubMed

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3  

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HumansCells

Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation. Sci Adv. 2021 Aug; 7(32). Li H, Doric Z, Berthet A, Jorgens DM, Nguyen MK, Hsieh I, Margulis J, Fang R, Debnath J, Sesaki H, Finkbeiner S, Huang E, Nakamura K. PMID: 34362731; PMCID: PMC8346224.

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PubMed

   Mentions:

9  

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Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. Genes Dev. 2021 07 01; 35(13-14):963-975. Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J. PMID: 34168038; PMCID: PMC8247603.

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24  

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HumansAnimalsCells

Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae. J Cell Sci. 2021 06 01; 134(11). Kaur J, Goldsmith J, Tankka A, Bustamante Eguiguren S, Gimenez AA, Vick L, Debnath J, Vlahakis A. PMID: 34096604; PMCID: PMC8214763.

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3  

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Humans

Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell. 2021 05 13; 184(10):2649-2664.e18. Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. PMID: 33848463; PMCID: PMC8127962.

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PubMed

   Mentions:

107  

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HumansCells

Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion. FASEB Bioadv. 2021 May; 3(5):377-386. Leidal AM, Debnath J. PMID: 33977236; PMCID: PMC8103724.

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   Mentions:

43  

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, et al. PMID: 33634751; PMCID: PMC7996087.

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1317  

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Beyond Autophagy: The Expanding Roles of ATG8 Proteins. Trends Biochem Sci. 2021 08; 46(8):673-686. Nieto-Torres JL, Leidal AM, Debnath J, Hansen M. PMID: 33558127; PMCID: PMC8286281.

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74  

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Cells

The pleiotropic functions of autophagy in metastasis. J Cell Sci. 2021 01 22; 134(2). Marsh T, Tolani B, Debnath J. PMID: 33483365; PMCID: PMC7847272.

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23  

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Humans

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Humans

Unconventional secretion: cargo channeling by TMED10. Cell Res. 2020 09; 30(9):713-714. Nguyen TA, Debnath J. PMID: 32728197; PMCID: PMC7608394.

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4  

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Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 12; 588(7838):459-465. Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. PMID: 32866962; PMCID: PMC7746606.

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103  

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AnimalsCells

Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Commun Biol. 2020 07 17; 3(1):388. Goldsmith J, Marsh T, Asthana S, Leidal AM, Suresh D, Olshen A, Debnath J. PMID: 32681145; PMCID: PMC7367890.

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8  

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AnimalsCells

LC3-dependent extracellular vesicle loading and secretion (LDELS). Autophagy. 2020 06; 16(6):1162-1163. Leidal AM, Debnath J. PMID: 32330402; PMCID: PMC7469500.

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26  

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Cells

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 05; 581(7806):100-105. Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. PMID: 32376951; PMCID: PMC7296553.

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669  

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HumansAnimalsCells

Autophagy suppresses breast cancer metastasis by degrading NBR1. Autophagy. 2020 06; 16(6):1164-1165. Marsh T, Debnath J. PMID: 32267786; PMCID: PMC7469534.

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68  

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Humans

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 03 09; 52(5):591-604.e6. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. PMID: 32084360; PMCID: PMC7108946.

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70  

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HumansAnimalsCells

Unraveling the mechanisms that specify molecules for secretion in extracellular vesicles. Methods. 2020 05 01; 177:15-26. Leidal AM, Debnath J. PMID: 31978536; PMCID: PMC7198338.

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35  

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HumansCells

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 02; 22(2):187-199. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. PMID: 31932738; PMCID: PMC7007875.

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296  

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HumansAnimalsCells

Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discov. 2019 09; 9(9):1167-1181. Amaravadi RK, Kimmelman AC, Debnath J. PMID: 31434711; PMCID: PMC7306856.

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526  

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HumansAnimals

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244  

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48  

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HumansAnimalsCells

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CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 09 14; 37(18). Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. PMID: 30166453; PMCID: PMC6138441.

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16  

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12  

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Humans

Atg12-Atg3 Coordinates Basal Autophagy, Endolysosomal Trafficking, and Exosome Release. Mol Cell Oncol. 2018; 5(5):e1039191. Murrow L, Debnath J. PMID: 30263931; PMCID: PMC6154856.

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9  

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. J Cell Biol. 2018 03 05; 217(3):813-822. Cadwell K, Debnath J. PMID: 29237720; PMCID: PMC5839790.

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58  

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HumansAnimalsCells

Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake. Autophagy. 2017; 13(11):2013-2014. Roy S, Debnath J. PMID: 28933603; PMCID: PMC5788470.

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Cells

Inflammatory signaling cascades and autophagy in cancer. Autophagy. 2018; 14(2):190-198. Monkkonen T, Debnath J. PMID: 28813180; PMCID: PMC5902219.

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98  

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HumansAnimalsCells

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. Mol Cell. 2017 Jul 06; 67(1):84-95.e5. Roy S, Leidal AM, Ye J, Ronen SM, Debnath J. PMID: 28602638; PMCID: PMC5522182.

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76  

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HumansAnimalsCells

Molecular definitions of autophagy and related processes. EMBO J. 2017 07 03; 36(13):1811-1836. Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. PMID: 28596378; PMCID: PMC5494474.

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914  

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Animals

The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 03 21; 46(3):405-420. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. PMID: 28314591; PMCID: PMC5400745.

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41  

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AnimalsCells

The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol. 2017 02 17; 429(4):515-530. Vlahakis A, Debnath J. PMID: 27932295; PMCID: PMC5276719.

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48  

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A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2017 Jan; 13(1):119-126. Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. PMID: 27870838; PMCID: PMC5161653.

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15  

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HumansCells

Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 12 01; 126(12):4417-4429. Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. PMID: 27775547; PMCID: PMC5127685.

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55  

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AnimalsCells

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AnimalsCells

Autophagy in adhesion and migration. J Cell Sci. 2016 10 15; 129(20):3685-3693. Kenific CM, Wittmann T, Debnath J. PMID: 27672021; PMCID: PMC5087656.

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61  

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At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. J Cell Biol. 2016 08 29; 214(5):503-5. Solvik T, Debnath J. PMID: 27573461; PMCID: PMC5004452.

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3  

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HumansAnimals

Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. PMID: 27568548; PMCID: PMC5023491.

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   Mentions:

197  

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AnimalsCells

NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy. 2016 10 02; 12(10):1958-1959. Kenific CM, Debnath J. PMID: 27484104; PMCID: PMC5079663.

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   Mentions:

14  

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HumansAnimalsCells

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PubMed

   Mentions:

50  

   Fields: 

   Translation:

Humans

NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 29; 212(5):577-90. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. PMID: 26903539; PMCID: PMC4772495.

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PubMed

   Mentions:

99  

   Fields: 

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HumansAnimalsCells

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.

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   Mentions:

3002  

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HumansAnimals

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 24; 528(7583):565-9. Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL. PMID: 26649827; PMCID: PMC4842313.

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   Mentions:

245  

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AnimalsCells

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   Mentions:

2  

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HumansAnimalsCells

Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2016 06 02; 35(22):2913-22. Salas E, Roy S, Marsh T, Rubin B, Debnath J. PMID: 26434592; PMCID: PMC4821829.

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   Mentions:

7  

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HumansCells

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PubMed

   Mentions:

507  

   Fields: 

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HumansAnimalsCells

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Publisher Site   Mentions:

Autophagy in malignant transformation and cancer progression. EMBO J. 2015 Apr 01; 34(7):856-80. Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. PMID: 25712477; PMCID: PMC4388596.

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PubMed

   Mentions:

680  

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HumansAnimals

ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015 Mar; 17(3):300-10. Murrow L, Malhotra R, Debnath J. PMID: 25686249; PMCID: PMC4344874.

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   Mentions:

181  

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AnimalsCells

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PubMed

   Mentions:

4  

   Fields: 

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HumansCells

Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction. Autophagy. 2015; 11(3):527-37. Mar FA, Debnath J, Stohr BA. PMID: 25751002; PMCID: PMC4502814.

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   Mentions:

9  

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HumansAnimalsCells

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PubMed

   Mentions:

15  

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Humans

ATG12-ATG3 connects basal autophagy and late endosome function. Autophagy. 2015; 11(6):961-2. Murrow L, Debnath J. PMID: 25998418; PMCID: PMC4502820.

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PubMed

   Mentions:

28  

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HumansAnimalsCells

Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015; 11(1):145-54. Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. PMID: 25585051; PMCID: PMC4502780.

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PubMed

   Mentions:

56  

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AnimalsCells

Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015 Jan; 25(1):37-45. Kenific CM, Debnath J. PMID: 25278333; PMCID: PMC4275311.

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   Mentions:

141  

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AnimalsCells

Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discov. 2014 Aug; 4(8):873-5. Amaravadi R, Debnath J. PMID: 25092744; PMCID: PMC4124512.

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   Mentions:

20  

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HumansAnimals

'Doubling down' on the autophagy pathway to suppress tumor growth. Genes Dev. 2014 Jun 01; 28(11):1137-9. Leidal AM, Debnath J. PMID: 24888584; PMCID: PMC4052759.

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   Mentions:

6  

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HumansAnimals

Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discov. 2014 Apr; 4(4):466-79. Lock R, Kenific CM, Leidal AM, Salas E, Debnath J. PMID: 24513958; PMCID: PMC3980002.

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PubMed

   Mentions:

170  

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HumansAnimalsCells

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014; 10(12):2269-78. Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW. PMID: 25629932; PMCID: PMC4502749.

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PubMed

   Mentions:

40  

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HumansAnimalsCells

Autophagy and cancer metabolism. Methods Enzymol. 2014; 542:25-57. Goldsmith J, Levine B, Debnath J. PMID: 24862259; PMCID: PMC5839656.

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   Mentions:

83  

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HumansAnimalsCells

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PubMed

   Mentions:

3  

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HumansAnimals

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Publisher Site   Mentions:

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin. Oncogene. 2014 May 08; 33(19):2441-53. Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. PMID: 23770848; PMCID: PMC3960370.

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PubMed

   Mentions:

10  

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HumansCells

IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy. 2013 Aug; 9(8):1214-27. Chen N, Debnath J. PMID: 23778976; PMCID: PMC3748193.

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PubMed

   Mentions:

49  

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HumansAnimalsCells

FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7. Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. PMID: 23389440; PMCID: PMC3579002.

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PubMed

   Mentions:

338  

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AnimalsCells

Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol. 2013; 734:73-89. Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso JA. PMID: 23143976; PMCID: PMC3651695.

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PubMed

   Mentions:

54  

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HumansAnimalsCells

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene. 2013 Oct 10; 32(41):4932-40. Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA. PMID: 23160380; PMCID: PMC3600386.

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PubMed

   Mentions:

93  

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HumansAnimalsCells

Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease. Annu Rev Pathol. 2013 Jan 24; 8:105-37. Murrow L, Debnath J. PMID: 23072311; PMCID: PMC3971121.

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PubMed

   Mentions:

285  

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HumansAnimals

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene. 2013 May 16; 32(20):2543-54. Chen N, Eritja N, Lock R, Debnath J. PMID: 22777351; PMCID: PMC3470740.

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PubMed

   Mentions:

26  

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HumansCells

Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. PMID: 22675028; PMCID: PMC3408423.

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PubMed

   Mentions:

13  

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HumansCells

Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One. 2012; 7(4):e36221. Lee HS, Daniels BH, Salas E, Bollen AW, Debnath J, Margeta M. PMID: 22558391; PMCID: PMC3338695.

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PubMed

   Mentions:

30  

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Humans

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, et al. PMID: 22966490; PMCID: PMC3404883.

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   Mentions:

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   Mentions:

8  

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HumansAnimals

A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. PMID: 21997368; PMCID: PMC3359482.

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PubMed

   Mentions:

143  

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Cells

The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia. 2011 Sep; 16(3):173-87. Debnath J. PMID: 21779879; PMCID: PMC3170851.

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   Mentions:

43  

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HumansAnimals

PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol. 2011 Sep; 31(17):3616-29. Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA. PMID: 21709020; PMCID: PMC3165554.

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PubMed

   Mentions:

165  

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HumansAnimalsCells

Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89. Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. PMID: 21678117.

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   Mentions:

55  

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   Mentions:

7  

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ATG12-ATG3 and mitochondria. Autophagy. 2011 Jan; 7(1):109-11. Radoshevich L, Debnath J. PMID: 21068544; PMCID: PMC3039733.

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   Mentions:

11  

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HumansAnimalsCells

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell. 2011 Jan 15; 22(2):165-78. Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, Debnath J. PMID: 21119005; PMCID: PMC3020913.

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   Mentions:

288  

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HumansAnimalsCells

Therapeutic implications of autophagy-mediated cell survival in gastrointestinal stromal tumor after treatment with imatinib mesylate. Autophagy. 2010 Nov; 6(8):1190-1. Rubin BP, Debnath J. PMID: 20930540; PMCID: PMC3359491.

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   Mentions:

14  

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Humans

Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. PMID: 21062993; PMCID: PMC3001107.

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   Mentions:

173  

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HumansAnimalsCells

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell. 2010 Aug 20; 142(4):590-600. Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J. PMID: 20723759; PMCID: PMC2925044.

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   Mentions:

169  

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HumansCells

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   Mentions:

7  

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HumansAnimalsCells

Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14333-8. Gupta A, Roy S, Lazar AJ, Wang WL, McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schoffski P, Trent JA, Debnath J, Rubin BP. PMID: 20660757; PMCID: PMC2922542.

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   Mentions:

121  

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Humans

Autophagy and tumorigenesis. Semin Immunopathol. 2010 Dec; 32(4):383-96. Roy S, Debnath J. PMID: 20589500; PMCID: PMC2999728.

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   Mentions:

67  

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HumansAnimalsCells

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010 Apr 01; 5(4):e9979. Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. PMID: 20376313; PMCID: PMC2848616.

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598  

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A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009 Dec 31; 3:122. Kim SH, Debnath J, Mostov K, Park S, Hunt CA. PMID: 20043854; PMCID: PMC2814811.

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18  

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Autophagy and tumorigenesis. FEBS Lett. 2010 Apr 02; 584(7):1427-35. Chen N, Debnath J. PMID: 20035753; PMCID: PMC2843775.

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98  

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Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol. 2010 Apr; 22(2):241-5. Kenific CM, Thorburn A, Debnath J. PMID: 19945838; PMCID: PMC2854304.

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166  

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Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009 May 28; 6:8. Kim SH, Park S, Mostov K, Debnath J, Hunt CA. PMID: 19476639; PMCID: PMC2696420.

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PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep. 2009 Feb; 10(2):173-9. N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ. PMID: 19148225; PMCID: PMC2637314.

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Extracellular matrix regulation of autophagy. Curr Opin Cell Biol. 2008 Oct; 20(5):583-8. Lock R, Debnath J. PMID: 18573652; PMCID: PMC2613490.

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Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol. 2008; 3:313-39. Hebner C, Weaver VM, Debnath J. PMID: 18039125.

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Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell. 2008 Mar; 19(3):797-806. Fung C, Lock R, Gao S, Salas E, Debnath J. PMID: 18094039; PMCID: PMC2262959.

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321  

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. PMID: 18188003; PMCID: PMC2654259.

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38  

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550  

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Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004 Apr 26; 165(2):263-73. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. PMID: 15117969; PMCID: PMC2172030.

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54  

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3438-43. Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS. PMID: 14993595; PMCID: PMC373480.

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105  

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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol. 2003 Oct 27; 163(2):315-26. Debnath J, Walker SJ, Brugge JS. PMID: 14568991; PMCID: PMC2173511.

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399  

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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. BMC Immunol. 2001; 2:3. Chamorro M, Czar MJ, Debnath J, Cheng G, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 11353545; PMCID: PMC31577.

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Tec family kinases modulate thresholds for thymocyte development and selection. J Exp Med. 2000 Oct 02; 192(7):987-1000. Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL. PMID: 11015440; PMCID: PMC2193319.

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rlk/TXK encodes two forms of a novel cysteine string tyrosine kinase activated by Src family kinases. Mol Cell Biol. 1999 Feb; 19(2):1498-507. Debnath J, Chamorro M, Czar MJ, Schaeffer EM, Lenardo MJ, Varmus HE, Schwartzberg PL. PMID: 9891083; PMCID: PMC116078.

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