John Hogenesch, PhD | Cincinnati Children's Hospital Medical Center

John Hogenesch, PhD | Cincinnati Children's Hospital Medical Center
John Hogenesch,
PhD
Professor,
UC Department of Pediatrics
john.hogenesch@cchmc.org
My Lab
Visit the Hogenesch Lab
About
Biography
I began my scientific career as a neuroscientist interested in how genes regulate behavior. A series of inspiring mentors propelled me to pursue those interests across industry and academia.
I've since worked with many scientists on projects in plants, flies, zebrafish, mice and people. This work has focused on the function of noncoding RNAs; building a Gene Atlas of the mouse, human and rat transcriptomes; and cell-based screening, among others.
I'm particularly interested in genome biology with a focus on the circadian clock. In my lab at Cincinnati Children’s Hospital Medical Center, we work to uncover the mechanisms of the circadian clock and apply that knowledge to medicine. For example, our lab has discovered several core clock genes and proven that they regulate physiology and behavior. This includes my discovery of the transcription factor Bmal1 — the master regulator of the mammalian clock — along with its paralog, Bmal2, and its partner, Npas2. Later, my lab characterized Rora/Rorb/Roc as key regulators of Bmal1 and circadian function. We also discovered Chrono as a non-canonical repressor of Bmal1/Clock, and Kpnb1 as a required transporter of the PER/CRY complex.
We are also applying the principles of circadian biology to hospital medicine by looking at time of day as a guide for medication administration.
My lab’s work on transcriptional outputs of the circadian clock in animal models and humans is leading to a wealth of new opportunities in circadian medicine and has spurred community contributions to the public databases GeneATLAS, Gene Wiki and CircaDB. We have also developed several widely used algorithms, including JTK, PSEA, MetaCycle and CYCLOPS.
I am a Penn Fellow and sit or have sat on the scientific advisory boards of Qiagen, Mimetics, Synchronicity, Bio-Rad and the Ryan Licht Sang Foundation Medical Committee. I have also advised the Gene Ontology (GO) consortium, the Environmental Protection Agency (EPA), and several institutes within the National Institutes of Health, including the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI) and the National Heart, Lung and Blood Institute (NHLBI).
Postdoctoral Training
: Genomics, Novartis, Basel, Switzerland,
PhD
: Neuroscience, Northwestern University, Evanston, IL, 1999,
BA
: History, University of Southern California, Los Angeles, CA, 1989,
BS
: Biology, University of Southern California, Los Angeles, CA, 1991,
Services and Specialties
Human Genetics
Research Areas
Human Genetics
Genomics
Immunobiology
Neuroscience
Pulmonary Medicine
Publications
Selected
CYCLOPS reveals human transcriptional rhythms in health and disease.
Anafi, RC
Francey, LJ
Hogenesch, JB
Kim, J
Proceedings of the National Academy of Sciences of the United States of America
2017
114
20
):
5312-5317
Selected
Circadian Rhythms: Move Over Neurons - Astrocytes Mediate SCN Clock Function.
Ruben, MD
Hogenesch, JB
Current Biology
2017
27
):
R350-R352
Selected
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.
Krishnaiah, SY
Wu, G
Altman, BJ
Growe, J
Rhoades, SD
Coldren, F
Venkataraman, A
Olarerin-George, AO
Francey, LJ
Mukherjee, S
Baur, JA
Dang, CV
Hogenesch, JB
Weljie, AM
Cell Metabolism
2017
25
):
961-974.e4
Selected
MetaCycle: an integrated R package to evaluate periodicity in large scale data.
Wu, G
Anafi, RC
Hughes, ME
Kornacker, K
Hogenesch, JB
Bioinformatics
2016
32
21
):
3351-3353
Selected
Discovering Biology in Periodic Data through Phase Set Enrichment Analysis (PSEA).
Zhang, R
Podtelezhnikov, AA
Hogenesch, JB
Anafi, RC
Journal of Biological Rhythms
2016
31
):
244-257
Selected
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Lee, Y
Jang, AR
Francey, LJ
Sehgal, A
Hogenesch, JB
eLife
2015
Selected
Assessing the prevalence of mycoplasma contamination in cell culture via a survey of NCBI's RNA-seq archive.
Olarerin-George, AO
Hogenesch, JB
Nucleic Acids Research (NAR)
2015
43
):
2535-2542
Selected
A circadian gene expression atlas in mammals: implications for biology and medicine.
Zhang, R
Lahens, NF
Ballance, HI
Hughes, ME
Hogenesch, JB
Proceedings of the National Academy of Sciences of the United States of America
2014
111
45
):
16219-16224
Selected
IVT-seq reveals extreme bias in RNA sequencing.
Lahens, NF
Kavakli, IH
Zhang, R
Hayer, K
Black, MB
Dueck, H
Pizarro, A
Kim, J
Irizarry, R
Thomas, RS
Grant, GR
Hogenesch, JB
Genome Biology
2014
15
):
R86
Selected
Machine learning helps identify CHRONO as a circadian clock component.
Anafi, RC
Lee, Y
Sato, TK
Venkataraman, A
Ramanathan, C
Kavakli, IH
Hughes, ME
Baggs, JE
Growe, J
Liu, AC
Kim, J
Hogenesch, JB
PLoS Biology
2014
12
):
e1001840
From the Blog
Cancer
For Children After Stem Cell Transplants, Food Timing Matters
John Hogenesch, PhD,
Christopher E. Dandoy, MD, MSc
2/15/2023
Genomics and Development
Circadian Medicine Research Featured in NYTimes Magazine
John Hogenesch, PhD
7/6/2022
Genomics and Development
How to Cure Jet Lag? Study Mutant Hamsters
John Hogenesch, PhD
4/26/2022
Perinatal
Spectral Lighting: Novel Science Leads to Innovative NICU Design
John Hogenesch, PhD,
James M. Greenberg, MD
...
8/3/2021
Genomics and Development
Our 2019 Research Annual Report
John Hogenesch, PhD,
Theresa Alenghat, VMD, PhD
...
2/4/2020
Quality and Safety
Room for Improvement in Drug Dosage Timing in Hospitals
John Hogenesch, PhD,
David F. Smith, MD, PhD
10/1/2019
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