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PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons. Sci Adv. 2023 07 28; 9(30):eadi0286. Alber S, Di Matteo P, Zdradzinski MD, Dalla Costa I, Medzihradszky KF, Kawaguchi R, Di Pizio A, Freund P, Panayotis N, Marvaldi L, Doron-Mandel E, Okladnikov N, Rishal I, Nevo R, Coppola G, Lee SJ, Sahoo PK, Burlingame AL, Twiss JL, Fainzilber M. PMID: 37506203; PMCID: PMC10381954.
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Cross-Linking Mass Spectrometry on P-Glycoprotein. Int J Mol Sci. 2023 Jun 25; 24(13). Gellen G, Klement E, Biwott K, Schlosser G, Kalló G, Csosz É, Medzihradszky KF, Bacso Z. PMID: 37445813; PMCID: PMC10341432.
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Chronic Cerebral Hypoperfusion-Induced Disturbed Proteostasis of Mitochondria and MAM Is Reflected in the CSF of Rats by Proteomic Analysis. Mol Neurobiol. 2023 Jun; 60(6):3158-3174. Tukacs V, Mittli D, Hunyadi-Gulyás É, Hlatky D, Medzihradszky KF, Darula Z, Nyitrai G, Czurkó A, Juhász G, Kardos J, Kékesi KA. PMID: 36808604; PMCID: PMC10122630.
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Multiple Layers of Complexity in O-Glycosylation Illustrated With the Urinary Glycoproteome. Mol Cell Proteomics. 2022 12; 21(12):100439. Pap A, Kiraly IE, Medzihradszky KF, Darula Z. PMID: 36334872; PMCID: PMC9758497.
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Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods. 2022 Jan; 19(1):130. Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley RJ, Cheng K, Choo MS, Edwards N, Goldman R, Hoffmann M, Hu Y, Huang Y, Kim JY, Kletter D, Liquet B, Liu M, Mechref Y, Meng B, Neelamegham S, Nguyen-Khuong T, Nilsson J, Pap A, Park GW, Parker BL, Pegg CL, Penninger JM, Phung TK, Pioch M, Rapp E, Sakalli E, Sanda M, Schulz BL, Scott NE, Sofronov G, Stadlmann J, Vakhrushev SY, Woo CM, Wu HY, Yang P, Ying W, Zhang H, Zhang Y, Zhao J, Zaia J, Haslam SM, Palmisano G, Yoo JS, Larson G, Khoo KH, Medzihradszky KF, Kolarich D, Packer NH, Thaysen-Andersen M. PMID: 34893784; PMCID: PMC8748192.
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Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods. 2021 11; 18(11):1304-1316. Kawahara R, Chernykh A, Alagesan K, Bern M, Cao W, Chalkley RJ, Cheng K, Choo MS, Edwards N, Goldman R, Hoffmann M, Hu Y, Huang Y, Kim JY, Kletter D, Liquet B, Liu M, Mechref Y, Meng B, Neelamegham S, Nguyen-Khuong T, Nilsson J, Pap A, Park GW, Parker BL, Pegg CL, Penninger JM, Phung TK, Pioch M, Rapp E, Sakalli E, Sanda M, Schulz BL, Scott NE, Sofronov G, Stadlmann J, Vakhrushev SY, Woo CM, Wu HY, Yang P, Ying W, Zhang H, Zhang Y, Zhao J, Zaia J, Haslam SM, Palmisano G, Yoo JS, Larson G, Khoo KH, Medzihradszky KF, Kolarich D, Packer NH, Thaysen-Andersen M. PMID: 34725484; PMCID: PMC8566223.
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Uncovering a novel function of the CCR4-NOT complex in phytochrome A-mediated light signalling in plants. Elife. 2021 03 30; 10. Schwenk P, Sheerin DJ, Ponnu J, Staudt AM, Lesch KL, Lichtenberg E, Medzihradszky KF, Hoecker U, Klement E, Viczián A, Hiltbrunner A. PMID: 33783355; PMCID: PMC8009681.
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Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice. Front Immunol. 2020; 11:599771. Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, Homolya L, Juhász G, Kékesi KA, Józsi M, Györffy BA, Kardos J. PMID: 33628204; PMCID: PMC7897678.
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The effectiveness of filtering glycopeptide peak list files for Y ions. Mol Omics. 2020 04 01; 16(2):147-155. Chalkley RJ, Medzihradszky KF, Darula Z, Pap A, Baker PR. PMID: 32065175.
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Novel O-linked sialoglycan structures in human urinary glycoproteins. Mol Omics. 2020 04 01; 16(2):156-164. Pap A, Tasnadi E, Medzihradszky KF, Darula Z. PMID: 32022078.
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CRK5 Protein Kinase Contributes to the Progression of Embryogenesis of Arabidopsis thaliana. Int J Mol Sci. 2019 Dec 04; 20(24). Baba AI, Valkai I, Labhane NM, Koczka L, Andrási N, Klement É, Darula Z, Medzihradszky KF, Szabados L, Fehér A, Rigó G, Cséplo Á. PMID: 31817249; PMCID: PMC6941128.
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A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain. Cell. 2019 09 05; 178(6):1362-1374.e16. Lin King JV, Emrick JJ, Kelly MJS, Herzig V, King GF, Medzihradszky KF, Julius D. PMID: 31447178; PMCID: PMC6731142.
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AtCRK5 Protein Kinase Exhibits a Regulatory Role in Hypocotyl Hook Development during Skotomorphogenesis. Int J Mol Sci. 2019 Jul 12; 20(14). Baba AI, Andrási N, Valkai I, Gorcsa T, Koczka L, Darula Z, Medzihradszky KF, Szabados L, Fehér A, Rigó G, Cséplo Á. PMID: 31336871; PMCID: PMC6678082.
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Characterization of Site-Specific N-Glycosylation. Methods Mol Biol. 2019; 1934:93-125. Hevér H, Darula Z, Medzihradszky KF. PMID: 31256376.
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Extended Sialylated O-Glycan Repertoire of Human Urinary Glycoproteins Discovered and Characterized Using Electron-Transfer/Higher-Energy Collision Dissociation. J Proteome Res. 2019 01 04; 18(1):280-291. Darula Z, Pap Á, Medzihradszky KF. PMID: 30407017.
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Translatome Regulation in Neuronal Injury and Axon Regrowth. eNeuro. 2018 Mar-Apr; 5(2). Rozenbaum M, Rajman M, Rishal I, Koppel I, Koley S, Medzihradszky KF, Oses-Prieto JA, Kawaguchi R, Amieux PS, Burlingame AL, Coppola G, Fainzilber M. PMID: 29756027; PMCID: PMC5944006.
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Status Report on the High-Throughput Characterization of Complex Intact O-Glycopeptide Mixtures. J Am Soc Mass Spectrom. 2018 06; 29(6):1210-1220. Pap A, Klement E, Hunyadi-Gulyas E, Darula Z, Medzihradszky KF. PMID: 29730764.
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Microtubule organization in presynaptic boutons relies on the formin DAAM. Development. 2018 03 16; 145(6). Migh E, Götz T, Földi I, Szikora S, Gombos R, Darula Z, Medzihradszky KF, Maléth J, Hegyi P, Sigrist S, Mihály J. PMID: 29487108.
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Salivary proteome profiling of oral squamous cell carcinoma in a Hungarian population. FEBS Open Bio. 2018 04; 8(4):556-569. Csosz É, Márkus B, Darula Z, Medzihradszky KF, Nemes J, Szabó E, Tozsér J, Kiss C, Márton I. PMID: 29632809; PMCID: PMC5881539.
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Analysis of Mammalian O-Glycopeptides-We Have Made a Good Start, but There is a Long Way to Go. Mol Cell Proteomics. 2018 01; 17(1):2-17. Darula Z, Medzihradszky KF. PMID: 29162637; PMCID: PMC5750848.
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Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):E2524-E2532. Zhang C, Medzihradszky KF, Sánchez EE, Basbaum AI, Julius D. PMID: 28265084; PMCID: PMC5373363.
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Identification of Extracellular Segments by Mass Spectrometry Improves Topology Prediction of Transmembrane Proteins. Sci Rep. 2017 02 13; 7:42610. Langó T, Róna G, Hunyadi-Gulyás É, Turiák L, Varga J, Dobson L, Várady G, Drahos L, Vértessy BG, Medzihradszky KF, Szakács G, Tusnády GE. PMID: 28211907; PMCID: PMC5304180.
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Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells. Sci Rep. 2017 01 11; 7:40590. Sipos A, Iván J, Bécsi B, Darula Z, Tamás I, Horváth D, Medzihradszky KF, Erdodi F, Lontay B. PMID: 28074910; PMCID: PMC5225440.
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Extracellular Protein Phosphorylation, the Neglected Side of the Modification. Mol Cell Proteomics. 2017 01; 16(1):1-7. Klement E, Medzihradszky KF. PMID: 27834735; PMCID: PMC5217775.
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Using "spectral families" to assess the reproducibility of glycopeptide enrichment: human serum O-glycosylation revisited. Anal Bioanal Chem. 2017 Jan; 409(2):539-550. Pap A, Medzihradszky KF, Darula Z. PMID: 27766363.
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Cysteine S-linked N-acetylglucosamine (S-GlcNAcylation), A New Post-translational Modification in Mammals. Mol Cell Proteomics. 2016 11; 15(11):3405-3411. Maynard JC, Burlingame AL, Medzihradszky KF. PMID: 27558639; PMCID: PMC5098038.
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Nucleolin-Mediated RNA Localization Regulates Neuron Growth and Cycling Cell Size. Cell Rep. 2016 08 09; 16(6):1664-1676. Perry RB, Rishal I, Doron-Mandel E, Kalinski AL, Medzihradszky KF, Terenzio M, Alber S, Koley S, Lin A, Rozenbaum M, Yudin D, Sahoo PK, Gomes C, Shinder V, Geraisy W, Huebner EA, Woolf CJ, Yaron A, Burlingame AL, Twiss JL, Fainzilber M. PMID: 27477284; PMCID: PMC4978702.
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Immobilized metal affinity chromatography optimized for the analysis of extracellular phosphorylation. Proteomics. 2016 07; 16(13):1858-62. Klement E, Raffai T, Medzihradszky KF. PMID: 27130503.
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MiniCORVET is a Vps8-containing early endosomal tether in Drosophila. Elife. 2016 06 02; 5. Lorincz P, Lakatos Z, Varga Á, Maruzs T, Simon-Vecsei Z, Darula Z, Benko P, Csordás G, Lippai M, Andó I, Hegedus K, Medzihradszky KF, Takáts S, Juhász G. PMID: 27253064; PMCID: PMC4935465.
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Maternal alterations in the proteome of the medial prefrontal cortex in rat. J Proteomics. 2017 02 05; 153:65-77. Völgyi K, Udvari EB, Szabó ÉR, Györffy BA, Hunyadi-Gulyás É, Medzihradszky K, Juhász G, Kékesi KA, Dobolyi Á. PMID: 27233742.
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Photoactivatable protein labeling by singlet oxygen mediated reactions. Bioorg Med Chem Lett. 2016 07 15; 26(14):3359-3363. To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. PMID: 27220724; PMCID: PMC4903891.
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N-Glycopeptide Profiling in Arabidopsis Inflorescence. Mol Cell Proteomics. 2016 06; 15(6):2048-54. Xu SL, Medzihradszky KF, Wang ZY, Burlingame AL, Chalkley RJ. PMID: 27067053; PMCID: PMC5083099.
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O-glycosylation sites identified from mucin core-1 type glycopeptides from human serum. Glycoconj J. 2016 06; 33(3):435-45. Darula Z, Sarnyai F, Medzihradszky KF. PMID: 26729242; PMCID: PMC4892982.
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Evaluation of 9-cis retinoic acid and mitotane as antitumoral agents in an adrenocortical xenograft model. Am J Cancer Res. 2015; 5(12):3645-58. Nagy Z, Baghy K, Hunyadi-Gulyás É, Micsik T, Nyíro G, Rácz G, Butz H, Perge P, Kovalszky I, Medzihradszky KF, Rácz K, Patócs A, Igaz P. PMID: 26885453; PMCID: PMC4731638.
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Isolation and analyses of axonal ribonucleoprotein complexes. Methods Cell Biol. 2016; 131:467-86. Doron-Mandel E, Alber S, Oses JA, Medzihradszky KF, Burlingame AL, Fainzilber M, Twiss JL, Lee SJ. PMID: 26794529; PMCID: PMC4924573.
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Carbamidomethylation Side Reactions May Lead to Glycan Misassignments in Glycopeptide Analysis. Anal Chem. 2015 Jun 16; 87(12):6297-302. Darula Z, Medzihradszky KF. PMID: 25978763.
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Tissue-Specific Glycosylation at the Glycopeptide Level. Mol Cell Proteomics. 2015 Aug; 14(8):2103-10. Medzihradszky KF, Kaasik K, Chalkley RJ. PMID: 25995273; PMCID: PMC4528240.
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Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades. Biochem J. 2015 Apr 01; 467(1):167-75. Nagy SK, Darula Z, Kállai BM, Bögre L, Bánhegyi G, Medzihradszky KF, Horváth GV, Mészáros T. PMID: 25646663.
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Identification of nodule-specific cysteine-rich plant peptides in endosymbiotic bacteria. Proteomics. 2015 Jul; 15(13):2291-5. Durgo H, Klement E, Hunyadi-Gulyas E, Szucs A, Kereszt A, Medzihradszky KF, Kondorosi E. PMID: 25690539.
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Structure-function analysis of peroxidasin provides insight into the mechanism of collagen IV crosslinking. Free Radic Biol Med. 2015 Jun; 83:273-82. Lázár E, Péterfi Z, Sirokmány G, Kovács HA, Klement E, Medzihradszky KF, Geiszt M. PMID: 25708780.
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Characterizing sialic acid variants at the glycopeptide level. Anal Chem. 2015 Mar 03; 87(5):3064-71. Medzihradszky KF, Kaasik K, Chalkley RJ. PMID: 25654559; PMCID: PMC4367445.
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Lessons in de novo peptide sequencing by tandem mass spectrometry. Mass Spectrom Rev. 2015 Jan-Feb; 34(1):43-63. Medzihradszky KF, Chalkley RJ. PMID: 25667941; PMCID: PMC4367481.
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The B″ regulatory subunit of protein phosphatase 2A mediates the dephosphorylation of rice retinoblastoma-related protein-1. Plant Mol Biol. 2015 Jan; 87(1-2):125-41. Ábrahám E, Yu P, Farkas I, Darula Z, Varga E, Lukács N, Ayaydin F, Medzihradszky KF, Dombrádi V, Dudits D, Horváth GV. PMID: 25398395.
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Noncovalent dimer formation in liquid chromatography-mass spectrometry analysis. Anal Chem. 2014 Sep 16; 86(18):8906-9. Medzihradszky KF. PMID: 25162384; PMCID: PMC4165458.
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The heat shock factor A4A confers salt tolerance and is regulated by oxidative stress and the mitogen-activated protein kinases MPK3 and MPK6. Plant Physiol. 2014 May; 165(1):319-34. Pérez-Salamó I, Papdi C, Rigó G, Zsigmond L, Vilela B, Lumbreras V, Nagy I, Horváth B, Domoki M, Darula Z, Medzihradszky K, Bögre L, Koncz C, Szabados L. PMID: 24676858; PMCID: PMC4012591.
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Glycan side reaction may compromise ETD-based glycopeptide identification. J Am Soc Mass Spectrom. 2014 Jun; 25(6):977-87. Darula Z, Medzihradszky KF. PMID: 24664807; PMCID: PMC4036456.
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Medicago truncatula symbiotic peptide NCR247 contributes to bacteroid differentiation through multiple mechanisms. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):5183-8. Farkas A, Maróti G, Durgo H, Györgypál Z, Lima RM, Medzihradszky KF, Kereszt A, Mergaert P, Kondorosi É. PMID: 24706863; PMCID: PMC3986156.
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A novel interplay between the ubiquitin–proteasome system and serine proteases during Drosophila development. Biochem J. 2013 Sep 15; 454(3):571-83. Lipinszki Z, Klement E, Hunyadi-Gulyas E, Medzihradszky KF, Márkus R, Pál M, Deák P, Udvardy A. PMID: 23805892.
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N- and O-glycosylation in the murine synaptosome. Mol Cell Proteomics. 2013 Dec; 12(12):3474-88. Trinidad JC, Schoepfer R, Burlingame AL, Medzihradszky KF. PMID: 23816992; PMCID: PMC3861701.
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Evolutionary and mechanistic insights into substrate and product accommodation of CTP:phosphocholine cytidylyltransferase from Plasmodium falciparum. FEBS J. 2013 Jul; 280(13):3132-48. Nagy GN, Marton L, Krámos B, Oláh J, Révész Á, Vékey K, Delsuc F, Hunyadi-Gulyás É, Medzihradszky KF, Lavigne M, Vial H, Cerdan R, Vértessy BG. PMID: 23578277.
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Inactivation of plasma membrane-localized CDPK-RELATED KINASE5 decelerates PIN2 exocytosis and root gravitropic response in Arabidopsis. Plant Cell. 2013 May; 25(5):1592-608. Rigó G, Ayaydin F, Tietz O, Zsigmond L, Kovács H, Páy A, Salchert K, Darula Z, Medzihradszky KF, Szabados L, Palme K, Koncz C, Cséplo A. PMID: 23673979; PMCID: PMC3694694.
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Phosphorylation of phytochrome B inhibits light-induced signaling via accelerated dark reversion in Arabidopsis. Plant Cell. 2013 Feb; 25(2):535-44. Medzihradszky M, Bindics J, Ádám É, Viczián A, Klement É, Lorrain S, Gyula P, Mérai Z, Fankhauser C, Medzihradszky KF, Kunkel T, Schäfer E, Nagy F. PMID: 23378619; PMCID: PMC3608776.
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Altered functional protein networks in the prefrontal cortex and amygdala of victims of suicide. PLoS One. 2012; 7(12):e50532. Kékesi KA, Juhász G, Simor A, Gulyássy P, Szego EM, Hunyadi-Gulyás E, Darula Z, Medzihradszky KF, Palkovits M, Penke B, Czurkó A. PMID: 23272063; PMCID: PMC3516509.
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Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis. J Am Chem Soc. 2012 Oct 31; 134(43):18074-81. McCusker KP, Medzihradszky KF, Shiver AL, Nichols RJ, Yan F, Maltby DA, Gross CA, Fujimori DG. PMID: 23088750; PMCID: PMC3499099.
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How to dig deeper? Improved enrichment methods for mucin core-1 type glycopeptides. Mol Cell Proteomics. 2012 Jul; 11(7):O111.016774. Darula Z, Sherman J, Medzihradszky KF. PMID: 22393263; PMCID: PMC3394963.
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Partial de novo sequencing and unusual CID fragmentation of a 7 kDa, disulfide-bridged toxin. J Am Soc Mass Spectrom. 2012 May; 23(5):923-34. Medzihradszky KF, Bohlen CJ. PMID: 22351294; PMCID: PMC4367482.
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A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain. Nature. 2011 Nov 16; 479(7373):410-4. Bohlen CJ, Chesler AT, Sharif-Naeini R, Medzihradszky KF, Zhou S, King D, Sánchez EE, Burlingame AL, Basbaum AI, Julius D. PMID: 22094702; PMCID: PMC3226747.
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Removal of nonspecific binding proteins from cell and tissue extracts using 2-aminobenzimidazole-tethered affinity resin. Pharmazie. 2011 Sep; 66(9):662-5. Molnár E, Fábián G, Klem J, Darula Z, Hunyadi-Gulyás E, Medgyesi A, Medzihradszky KF, Puskás LG. PMID: 22026120.
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Unusual fragmentation of Pro-Ser/Thr-containing peptides detected in collision-induced dissociation spectra. J Am Soc Mass Spectrom. 2012 Apr; 23(4):602-7. Medzihradszky KF, Trinidad JC. PMID: 21952759; PMCID: PMC3384711.
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Calpain-catalyzed proteolysis of human dUTPase specifically removes the nuclear localization signal peptide. PLoS One. 2011; 6(5):e19546. Bozóky Z, Róna G, Klement É, Medzihradszky KF, Merényi G, Vértessy BG, Friedrich P. PMID: 21625588; PMCID: PMC3098232.
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A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid. Biochemistry. 2011 Apr 12; 50(14):3014-24. Sivaramakrishnan S, Ouellet H, Du J, McLean KJ, Medzihradszky KF, Dawson JH, Munro AW, Ortiz de Montellano PR. PMID: 21381758; PMCID: PMC3071435.
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Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding. FEBS J. 2011 Jan; 278(2):295-315. Bekesi A, Pukancsik M, Haasz P, Felfoldi L, Leveles I, Muha V, Hunyadi-Gulyas E, Erdei A, Medzihradszky KF, Vertessy BG. PMID: 21134127.
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The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion. J Biol Chem. 2011 Jan 07; 286(1):429-40. Swenerton RK, Zhang S, Sajid M, Medzihradszky KF, Craik CS, Kelly BL, McKerrow JH. PMID: 20961853; PMCID: PMC3013002.
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Protein PTMs: post-translational modifications or pesky trouble makers? J Mass Spectrom. 2010 Oct; 45(10):1095-7. Bradshaw RA, Medzihradszky KF, Chalkley RJ. PMID: 20635432; PMCID: PMC3133960.
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Comparison of transcriptional and translational changes caused by long-term menadione exposure in Aspergillus nidulans. Fungal Genet Biol. 2011 Feb; 48(2):92-103. Pusztahelyi T, Klement E, Szajli E, Klem J, Miskei M, Karányi Z, Emri T, Kovács S, Orosz G, Kovács KL, Medzihradszky KF, Prade RA, Pócsi I. PMID: 20797444.
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Improved identification of O-linked glycopeptides from ETD data with optimized scoring for different charge states and cleavage specificities. Amino Acids. 2011 Jul; 41(2):321-8. Darula Z, Chalkley RJ, Lynn A, Baker PR, Medzihradszky KF. PMID: 20652609; PMCID: PMC3102200.
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Signaling to transcription networks in the neuronal retrograde injury response. Sci Signal. 2010 Jul 13; 3(130):ra53. Michaelevski I, Segal-Ruder Y, Rozenbaum M, Medzihradszky KF, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan SY, Rishal I, Geschwind DH, Pilpel Y, Burlingame AL, Fainzilber M. PMID: 20628157; PMCID: PMC3645873.
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BspRI restriction endonuclease: cloning, expression in Escherichia coli and sequential cleavage mechanism. Nucleic Acids Res. 2010 Nov; 38(20):7155-66. Raskó T, Dér A, Klement E, Slaska-Kiss K, Pósfai E, Medzihradszky KF, Marshak DR, Roberts RJ, Kiss A. PMID: 20587501; PMCID: PMC2978348.
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Identification of β-lactamases in human and bovine isolates of Staphylococcus aureus strains having borderline resistance to penicillinase-resistant penicillins (PRPs) with proteomic methods. Vet Microbiol. 2011 Jan 10; 147(1-2):96-102. Keseru JS, Szabó I, Gál Z, Massidda O, Mingoia M, Kaszanyitzky E, Jánosi S, Hulvely J, Csorba A, Buzás K, Hunyadi-Gulyás E, Medzihradszky KF, Biró S. PMID: 20599331.
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Improving software performance for peptide electron transfer dissociation data analysis by implementation of charge state- and sequence-dependent scoring. Mol Cell Proteomics. 2010 Sep; 9(9):1795-803. Baker PR, Medzihradszky KF, Chalkley RJ. PMID: 20513802; PMCID: PMC2938109.
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Enrichment of O-GlcNAc modified proteins by the periodate oxidation-hydrazide resin capture approach. J Proteome Res. 2010 May 07; 9(5):2200-6. Klement E, Lipinszki Z, Kupihár Z, Udvardy A, Medzihradszky KF. PMID: 20146544; PMCID: PMC2866058.
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The genome of Beet cryptic virus 1 shows high homology to certain cryptoviruses present in phylogenetically distant hosts. Virus Genes. 2010 Apr; 40(2):267-76. Szego A, Enünlü N, Deshmukh SD, Veliceasa D, Hunyadi-Gulyás E, Kühne T, Ilyés P, Potyondi L, Medzihradszky K, Lukács N. PMID: 20058060.
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Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities. Protein Sci. 2010 Mar; 19(3):458-74. Cade CE, Dlouhy AC, Medzihradszky KF, Salas-Castillo SP, Ghiladi RA. PMID: 20054829; PMCID: PMC2866272.
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Axoplasm isolation from peripheral nerve. Dev Neurobiol. 2010 Feb; 70(2):126-33. Rishal I, Michaelevski I, Rozenbaum M, Shinder V, Medzihradszky KF, Burlingame AL, Fainzilber M. PMID: 19885832; PMCID: PMC2857660.
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Physiological truncation and domain organization of a novel uracil-DNA-degrading factor. FEBS J. 2010 Mar; 277(5):1245-59. Pukáncsik M, Békési A, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kosinski J, Bujnicki JM, Alfonso C, Rivas G, Vértessy BG. PMID: 20121948.
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Statistical analysis of Peptide electron transfer dissociation fragmentation mass spectrometry. Anal Chem. 2010 Jan 15; 82(2):579-84. Chalkley RJ, Medzihradszky KF, Lynn AJ, Baker PR, Burlingame AL. PMID: 20028093; PMCID: PMC2836188.
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Mass spectrometric analysis, automated identification and complete annotation of O-linked glycopeptides. Eur J Mass Spectrom (Chichester). 2010; 16(3):421-8. Darula Z, Chalkley RJ, Baker P, Burlingame AL, Medzihradszky KF. PMID: 20530845; PMCID: PMC2963623.
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Axonal transport proteomics reveals mobilization of translation machinery to the lesion site in injured sciatic nerve. Mol Cell Proteomics. 2010 May; 9(5):976-87. Michaelevski I, Medzihradszky KF, Lynn A, Burlingame AL, Fainzilber M. PMID: 19955087; PMCID: PMC2871428.
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Affinity enrichment and characterization of mucin core-1 type glycopeptides from bovine serum. Mol Cell Proteomics. 2009 Nov; 8(11):2515-26. Darula Z, Medzihradszky KF. PMID: 19674964; PMCID: PMC2773718.
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Regulation of calpain B from Drosophila melanogaster by phosphorylation. FEBS J. 2009 Sep; 276(17):4959-72. Kovács L, Alexa A, Klement E, Kókai E, Tantos A, Gógl G, Sperka T, Medzihradszky KF, Tözsér J, Dombrádi V, Friedrich P. PMID: 19694808.
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Developmental-stage-specific regulation of the polyubiquitin receptors in Drosophila melanogaster. J Cell Sci. 2009 Sep 01; 122(Pt 17):3083-92. Lipinszki Z, Kiss P, Pál M, Deák P, Szabó A, Hunyadi-Gulyas E, Klement E, Medzihradszky KF, Udvardy A. PMID: 19654212.
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Lack of A-factor production induces the expression of nutrient scavenging and stress-related proteins in Streptomyces griseus. Mol Cell Proteomics. 2009 Oct; 8(10):2396-403. Birkó Z, Swiatek M, Szájli E, Medzihradszky KF, Vijgenboom E, Penyige A, Keseru J, van Wezel GP, Biró S. PMID: 19625340; PMCID: PMC2758764.
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Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J Med Chem. 2009 Jun 25; 52(12):3735-41. Tomizawa M, Talley TT, Park JF, Maltby D, Medzihradszky KF, Durkin KA, Cornejo-Bravo JM, Burlingame AL, Casida JE, Taylor P. PMID: 19459645; PMCID: PMC2748672.
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Spin scavenging analysis of myoglobin protein-centered radicals using stable nitroxide radicals: characterization of oxoammonium cation-induced modifications. Chem Res Toxicol. 2009 Jun; 22(6):1034-49. Lardinois OM, Maltby DA, Medzihradszky KF, de Montellano PR, Tomer KB, Mason RP, Deterding LJ. PMID: 19449826; PMCID: PMC2862229.
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Mutator transposon activity reprograms the transcriptomes and proteomes of developing maize anthers. Plant J. 2009 Aug; 59(4):622-33. Skibbe DS, Fernandes JF, Medzihradszky KF, Burlingame AL, Walbot V. PMID: 19453454.
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Identification of new p53 acetylation sites in COS-1 cells. Mol Cell Proteomics. 2009 Jun; 8(6):1167-73. Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL. PMID: 19155208; PMCID: PMC2690490.
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Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand. J Inorg Biochem. 2009 Mar; 103(3):316-25. Jiang Y, Trnka MJ, Medzihradszky KF, Ouellet H, Wang Y, Ortiz de Montellano PR. PMID: 19135260; PMCID: PMC2762215.
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Electron-transfer subunits of the NiFe hydrogenases in Thiocapsa roseopersicina BBS. FEBS J. 2009 Jan; 276(1):164-74. Palágyi-Mészáros LS, Maróti J, Latinovics D, Balogh T, Klement E, Medzihradszky KF, Rákhely G, Kovács KL. PMID: 19019079.
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Identifying calpain substrates in intact S2 cells of Drosophila. Arch Biochem Biophys. 2009 Jan 15; 481(2):219-25. Bozoky Z, Alexa A, Dancsok J, Gogl G, Klement E, Medzihradszky KF, Friedrich P. PMID: 19038228.
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Cloning and characterization of the DNA region responsible for Megacin A-216 production in Bacillus megaterium 216. J Bacteriol. 2008 Oct; 190(19):6448-57. Kiss A, Balikó G, Csorba A, Chuluunbaatar T, Medzihradszky KF, Alföldi L. PMID: 18689470; PMCID: PMC2565993.
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In-depth analysis of tandem mass spectrometry data from disparate instrument types. Mol Cell Proteomics. 2008 Dec; 7(12):2386-98. Chalkley RJ, Baker PR, Medzihradszky KF, Lynn AJ, Burlingame AL. PMID: 18653769; PMCID: PMC2596346.
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Investigating the quantitative nature of MALDI-TOF MS. Mol Cell Proteomics. 2008 Dec; 7(12):2410-8. Szájli E, Fehér T, Medzihradszky KF. PMID: 18653768.
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Proteomic analysis of skin invasion by blood fluke larvae. PLoS Negl Trop Dis. 2008 Jul 16; 2(7):e262. Hansell E, Braschi S, Medzihradszky KF, Sajid M, Debnath M, Ingram J, Lim KC, McKerrow JH. PMID: 18629379; PMCID: PMC2467291.
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Intrinsic structural disorder of DF31, a Drosophila protein of chromatin decondensation and remodeling activities. J Proteome Res. 2008 Jun; 7(6):2291-9. Szollosi E, Bokor M, Bodor A, Perczel A, Klement E, Medzihradszky KF, Tompa K, Tompa P. PMID: 18484763.
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Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport. Plant Physiol. 2008 Apr; 146(4):1721-37. Zsigmond L, Rigó G, Szarka A, Székely G, Otvös K, Darula Z, Medzihradszky KF, Koncz C, Koncz Z, Szabados L. PMID: 18305213; PMCID: PMC2287346.
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Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1728-32. Tomizawa M, Maltby D, Talley TT, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. PMID: 18230720; PMCID: PMC2234212.
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Characterization of site-specific N-glycosylation. Methods Mol Biol. 2008; 446:293-316. Medzihradszky KF. PMID: 18373266.
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Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase. FEBS Lett. 2007 Oct 02; 581(24):4783-8. Varga B, Barabás O, Kovári J, Tóth J, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Tölgyesi F, Fidy J, Vértessy BG. PMID: 17880943.
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Differential use of protease families for invasion by schistosome cercariae. Biochimie. 2008 Feb; 90(2):345-58. Dvorák J, Mashiyama ST, Braschi S, Sajid M, Knudsen GM, Hansell E, Lim KC, Hsieh I, Bahgat M, Mackenzie B, Medzihradszky KF, Babbitt PC, Caffrey CR, McKerrow JH. PMID: 17936488.
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Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells. Cell Biol Int. 2008 Feb; 32(2):198-209. Hutamekalin P, Farkas AE, Orbók A, Wilhelm I, Nagyoszi P, Veszelka S, Deli MA, Buzás K, Hunyadi-Gulyás E, Medzihradszky KF, Meksuriyen D, Krizbai IA. PMID: 17920942.
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Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor. J Pharmacol Exp Ther. 2007 Dec; 323(3):979-89. Liao M, Pabarcus MK, Wang Y, Hefner C, Maltby DA, Medzihradszky KF, Salas-Castillo SP, Yan J, Maher JJ, Correia MA. PMID: 17761498.
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Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): identification of sites targeted by different kinases. J Biol Chem. 2007 Oct 05; 282(40):29531-9. Hlavanda E, Klement E, Kókai E, Kovács J, Vincze O, Tökési N, Orosz F, Medzihradszky KF, Dombrádi V, Ovádi J. PMID: 17693641.
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Defining nicotinic agonist binding surfaces through photoaffinity labeling. Biochemistry. 2007 Jul 31; 46(30):8798-806. Tomizawa M, Maltby D, Medzihradszky KF, Zhang N, Durkin KA, Presley J, Talley TT, Taylor P, Burlingame AL, Casida JE. PMID: 17614369; PMCID: PMC4778401.
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Sulfopeptide fragmentation in electron-capture and electron-transfer dissociation. J Am Soc Mass Spectrom. 2007 Sep; 18(9):1617-24. Medzihradszky KF, Guan S, Maltby DA, Burlingame AL. PMID: 17629708.
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Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97? Biochemistry. 2007 Jul 03; 46(26):7793-803. Faouzi S, Medzihradszky KF, Hefner C, Maher JJ, Correia MA. PMID: 17550236; PMCID: PMC2536616.
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Mapping the elusive neonicotinoid binding site. Proc Natl Acad Sci U S A. 2007 May 22; 104(21):9075-80. Tomizawa M, Talley TT, Maltby D, Durkin KA, Medzihradszky KF, Burlingame AL, Taylor P, Casida JE. PMID: 17485662; PMCID: PMC1885630.
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The secreted signaling protein factor C triggers the A-factor response regulon in Streptomyces griseus: overlapping signaling routes. Mol Cell Proteomics. 2007 Jul; 6(7):1248-56. Birkó Z, Bialek S, Buzás K, Szájli E, Traag BA, Medzihradszky KF, Rigali S, Vijgenboom E, Penyige A, Kele Z, van Wezel GP, Biró S. PMID: 17376769.
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A novel fruitfly protein under developmental control degrades uracil-DNA. Biochem Biophys Res Commun. 2007 Apr 13; 355(3):643-8. Békési A, Pukáncsik M, Muha V, Zagyva I, Leveles I, Hunyadi-Gulyás E, Klement E, Medzihradszky KF, Kele Z, Erdei A, Felföldi F, Kónya E, Vértessy BG. PMID: 17306761.
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High mobility group box 1 protein induction by Mycobacterium bovis BCG. Mediators Inflamm. 2007; 2007:53805. Hofner P, Seprényi G, Miczák A, Buzás K, Gyulai Z, Medzihradszky KF, Rouhiainen A, Rauvala H, Mándi Y. PMID: 18288272; PMCID: PMC2233895.
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Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins. Nucleic Acids Res. 2007; 35(2):495-505. Németh-Pongrácz V, Barabás O, Fuxreiter M, Simon I, Pichová I, Rumlová M, Zábranská H, Svergun D, Petoukhov M, Harmat V, Klement E, Hunyadi-Gulyás E, Medzihradszky KF, Kónya E, Vértessy BG. PMID: 17169987; PMCID: PMC1802613.
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Evidence for an extended interacting surface between beta-amyloid and serum amyloid P component. Neurosci Lett. 2007 Jan 22; 412(1):51-5. Likó I, Mák M, Klement E, Hunyadi-Gulyás E, Pázmány T, Medzihradszky KF, Urbányi Z. PMID: 17141957.
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Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions. Biochemistry. 2006 Nov 21; 45(46):13818-26. Vincze O, Tökési N, Oláh J, Hlavanda E, Zotter A, Horváth I, Lehotzky A, Tirián L, Medzihradszky KF, Kovács J, Orosz F, Ovádi J. PMID: 17105200.
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Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies. FEBS Lett. 2006 Oct 30; 580(25):5807-14. Oláh J, Tokési N, Vincze O, Horváth I, Lehotzky A, Erdei A, Szájli E, Medzihradszky KF, Orosz F, Kovács GG, Ovádi J. PMID: 17027006.
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Novel extracellular chitinases rapidly and specifically induced by general bacterial elicitors and suppressed by virulent bacteria as a marker of early basal resistance in tobacco. Mol Plant Microbe Interact. 2006 Feb; 19(2):161-72. Ott PG, Varga GJ, Szatmári A, Bozsó Z, Klement E, Medzihradszky KF, Besenyei E, Czelleng A, Klement Z. PMID: 16529378.
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O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2006 May; 5(5):923-34. Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL. PMID: 16452088.
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Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I). Biochemistry. 2005 Nov 22; 44(46):15093-105. Ghiladi RA, Medzihradszky KF, Ortiz de Montellano PR. PMID: 16285713.
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Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Biochem J. 2005 Oct 15; 391(Pt 2):301-10. Kiss P, Szabó A, Hunyadi-Gulyás E, Medzihradszky KF, Lipinszki Z, Pál M, Udvardy A. PMID: 15946124; PMCID: PMC1276928.
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Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG. J Am Chem Soc. 2005 Sep 28; 127(38):13428-42. Ghiladi RA, Medzihradszky KF, Rusnak FM, Ortiz de Montellano PR. PMID: 16173777.
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Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biol Chem. 2005 Sep; 386(9):931-40. Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. PMID: 16164418.
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Proteomic analysis of Schistosoma mansoni cercarial secretions. Mol Cell Proteomics. 2005 Dec; 4(12):1862-75. Knudsen GM, Medzihradszky KF, Lim KC, Hansell E, McKerrow JH. PMID: 16112986.
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Identification of synaptic plasma membrane proteins co-precipitated with fibrillar beta-amyloid peptide. J Neurochem. 2005 Aug; 94(3):617-28. Verdier Y, Huszár E, Penke B, Penke Z, Woffendin G, Scigelova M, Fülöp L, Szucs M, Medzihradszky K, Janáky T. PMID: 16001971.
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Comprehensive analysis of a multidimensional liquid chromatography mass spectrometry dataset acquired on a quadrupole selecting, quadrupole collision cell, time-of-flight mass spectrometer: I. How much of the data is theoretically interpretable by search engines? Mol Cell Proteomics. 2005 Aug; 4(8):1189-93. Chalkley RJ, Baker PR, Hansen KC, Medzihradszky KF, Allen NP, Rexach M, Burlingame AL. PMID: 15923566.
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The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties. J Biol Chem. 2005 Jun 17; 280(24):22651-63. Ghiladi RA, Knudsen GM, Medzihradszky KF, Ortiz de Montellano PR. PMID: 15840564.
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Primary contact sites in intrinsically unstructured proteins: the case of calpastatin and microtubule-associated protein 2. Biochemistry. 2005 Mar 15; 44(10):3955-64. Csizmók V, Bokor M, Bánki P, Klement E, Medzihradszky KF, Friedrich P, Tompa K, Tompa P. PMID: 15751971.
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Parotid secretory protein is an HDL-associated protein with anticandidal activity. Am J Physiol Regul Integr Comp Physiol. 2005 May; 288(5):R1306-15. Khovidhunkit W, Hachem JP, Medzihradszky KF, Duchateau PN, Shigenaga JK, Moser AH, Movsesyan I, Naya-Vigne J, Kane JP, Feingold KR, Grunfeld C. PMID: 15637169.
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Peptide sequence analysis. Methods Enzymol. 2005; 402:209-44. Medzihradszky KF. PMID: 16401511.
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Characterization of protein N-glycosylation. Methods Enzymol. 2005; 405:116-38. Medzihradszky KF. PMID: 16413313.
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In-solution digestion of proteins for mass spectrometry. Methods Enzymol. 2005; 405:50-65. Medzihradszky KF. PMID: 16413310.
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Apolipoproteins A-IV and A-V are acute-phase proteins in mouse HDL. Atherosclerosis. 2004 Sep; 176(1):37-44. Khovidhunkit W, Duchateau PN, Medzihradszky KF, Moser AH, Naya-Vigne J, Shigenaga JK, Kane JP, Grunfeld C, Feingold KR. PMID: 15306172.
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An antibiotic factory caught in action. Nat Struct Mol Biol. 2004 Sep; 11(9):888-93. Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. PMID: 15286722.
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Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS). Mol Cell Proteomics. 2004 Sep; 3(9):872-86. Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL. PMID: 15199121.
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Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biol Chem. 2004 Jun; 385(6):473-80. Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. PMID: 15255178.
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Developmental regulation of dUTPase in Drosophila melanogaster. J Biol Chem. 2004 May 21; 279(21):22362-70. Békési A, Zagyva I, Hunyadi-Gulyás E, Pongrácz V, Kovári J, Nagy AO, Erdei A, Medzihradszky KF, Vértessy BG. PMID: 14996835.
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Differential proteomics reveals multiple components in retrogradely transported axoplasm after nerve injury. Mol Cell Proteomics. 2004 May; 3(5):510-20. Perlson E, Medzihradszky KF, Darula Z, Munno DW, Syed NI, Burlingame AL, Fainzilber M. PMID: 14973157.
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From snails to sciatic nerve: Retrograde injury signaling from axon to soma in lesioned neurons. J Neurobiol. 2004 Feb 05; 58(2):287-94. Perlson E, Hanz S, Medzihradszky KF, Burlingame AL, Fainzilber M. PMID: 14704959.
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Modular broad-host-range expression vectors for single-protein and protein complex purification. Appl Environ Microbiol. 2004 Feb; 70(2):712-21. Fodor BD, Kovács AT, Csáki R, Hunyadi-Gulyás E, Klement E, Maróti G, Mészáros LS, Medzihradszky KF, Rákhely G, Kovács KL. PMID: 14766546; PMCID: PMC348848.
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O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. Mol Cell Proteomics. 2004 May; 3(5):429-40. Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL. PMID: 14752058.
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Multidimensional NMR identifies the conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer. J Biol Chem. 2004 Apr 23; 279(17):17945-50. Dubrovay Z, Gáspári Z, Hunyadi-Gulyás E, Medzihradszky KF, Perczel A, Vértessy BG. PMID: 14724273.
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26S proteasome subunits are O-linked N-acetylglucosamine-modified in Drosophila melanogaster. Biochem Biophys Res Commun. 2003 Dec 26; 312(4):1284-9. Sümegi M, Hunyadi-Gulyás E, Medzihradszky KF, Udvardy A. PMID: 14652013.
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Glycoforms obtained by expression in Pichia pastoris improve cancer targeting potential of a recombinant antibody-enzyme fusion protein. Glycobiology. 2004 Jan; 14(1):27-37. Medzihradszky KF, Spencer DI, Sharma SK, Bhatia J, Pedley RB, Read DA, Begent RH, Chester KA. PMID: 14514711.
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Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9590-5. Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, Peters C, Bogyo M, Hook V. PMID: 12869695; PMCID: PMC170962.
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Synthesis of the C-terminal domain of the tissue inhibitor of metalloproteinases-1 (TIMP-1). J Pept Sci. 2003 Jul; 9(7):430-41. Bódi J, Mihala N, Hajnal A, Medzihradszky KF, Süli-Vargha H. PMID: 12916640.
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Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Biochemistry. 2002 Jul 09; 41(27):8657-64. Hlavanda E, Kovács J, Oláh J, Orosz F, Medzihradszky KF, Ovádi J. PMID: 12093283.
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The identification of protein-protein interactions of the nuclear pore complex of Saccharomyces cerevisiae using high throughput matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Mol Cell Proteomics. 2002 Jun; 1(6):434-50. Huang L, Baldwin MA, Maltby DA, Medzihradszky KF, Baker PR, Allen N, Rexach M, Edmondson RD, Campbell J, Juhasz P, Martin SA, Vestal ML, Burlingame AL. PMID: 12169684.
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Characterization of site-specific glycosylation. Methods Mol Biol. 2002; 194:101-25. Medzihradszky KF. PMID: 12029830.
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Phosphorylation of native and heme-modified CYP3A4 by protein kinase C: a mass spectrometric characterization of the phosphorylated peptides. Biochemistry. 2001 Sep 25; 40(38):11318-26. Wang X, Medzihradszky KF, Maltby D, Correia MA. PMID: 11560479.
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Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation. J Chromatogr B Biomed Sci Appl. 2001 Aug 05; 759(1):1-15. Zhang X, Medzihradszky KF, Cunningham J, Lee PD, Rognerud CL, Ou CN, Harmatz P, Witkowska HE. PMID: 11499613.
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Matrix-assisted laser desorption/ionization coupled with quadrupole/orthogonal acceleration time-of-flight mass spectrometry for protein discovery, identification, and structural analysis. Anal Chem. 2001 Apr 15; 73(8):1707-20. Baldwin MA, Medzihradszky KF, Lock CM, Fisher B, Settineri TA, Burlingame AL. PMID: 11338583.
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Protein identification by in-gel digestion, high-performance liquid chromatography, and mass spectrometry: peptide analysis by complementary ionization techniques. J Am Soc Mass Spectrom. 2001 Feb; 12(2):215-21. Medzihradszky KF, Leffler H, Baldwin MA, Burlingame AL. PMID: 11212006.
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Strategies for the synthesis of labeled peptides. J Biomol Tech. 2000 Dec; 11(4):155-65. Bibbs L, Ambulos NP, Kates SA, Khatri A, Medzihradszky KF, Osapay G, Weintraub ST. PMID: 19499054; PMCID: PMC2291636.
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Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chem Biol. 2000 Aug; 7(8):569-81. Greenbaum D, Medzihradszky KF, Burlingame A, Bogyo M. PMID: 11048948.
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The characteristics of peptide collision-induced dissociation using a high-performance MALDI-TOF/TOF tandem mass spectrometer. Anal Chem. 2000 Feb 01; 72(3):552-8. Medzihradszky KF, Campbell JM, Baldwin MA, Falick AM, Juhasz P, Vestal ML, Burlingame AL. PMID: 10695141.
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Spin trapping and protein cross-linking of the lactoperoxidase protein radical. J Biol Chem. 1999 Dec 10; 274(50):35441-8. Lardinois OM, Medzihradszky KF, Ortiz de Montellano PR. PMID: 10585414.
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Study on the synthesis and characterization of peptides containing phosphorylated tyrosine. J Pept Res. 1999 Feb; 53(2):161-9. Bonewald LF, Bibbs L, Kates SA, Khatri A, McMurray JS, Medzihradszky KF, Weintraub ST. PMID: 10195453.
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Fragmentation and sequencing of cyclic peptides by matrix-assisted laser desorption/ionization post-source decay mass spectrometry. Rapid Commun Mass Spectrom. 1999; 13(21):2174-9. Schilling B, Wang W, McMurray JS, Medzihradszky KF. PMID: 10523777.
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Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity. Biochemistry. 1998 Apr 07; 37(14):4916-27. Prakobphol A, Thomsson KA, Hansson GC, Rosen SD, Singer MS, Phillips NJ, Medzihradszky KF, Burlingame AL, Leffler H, Fisher SJ. PMID: 9538010.
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Heme oxygenase active-site residues identified by heme-protein cross-linking during reduction of CBrCl3. Biochemistry. 1998 Mar 03; 37(9):2889-96. Wilks A, Medzihradszky KF, Ortiz de Montellano PR. PMID: 9485440.
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Reverse-phase capillary high performance liquid chromatography/high performance electrospray ionization mass spectrometry: an essential tool for the characterization of complex glycoprotein digests. Rapid Commun Mass Spectrom. 1998; 12(8):472-8. Medzihradszky KF, Besman MJ, Burlingame AL. PMID: 9586235.
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Structural characterization of site-specific N-glycosylation of recombinant human factor VIII by reversed-phase high-performance liquid chromatography-electrospray ionization mass spectrometry. Anal Chem. 1997 Oct 01; 69(19):3986-94. Medzihradszky KF, Besman MJ, Burlingame AL. PMID: 9322435.
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Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies. J Med Chem. 1997 Jul 04; 40(14):2241-51. Osapay G, Prokai L, Kim HS, Medzihradszky KF, Coy DH, Liapakis G, Reisine T, Melacini G, Zhu Q, Wang SH, Mattern RH, Goodman M. PMID: 9216843.
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Synthesis and characterization of histidine-phosphorylated peptides. Protein Sci. 1997 Jul; 6(7):1405-11. Medzihradszky KF, Phillipps NJ, Senderowicz L, Wang P, Turck CW. PMID: 9232641; PMCID: PMC2143754.
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A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains. Science. 1996 Aug 23; 273(5278):1078-84. Wang SX, Mure M, Medzihradszky KF, Burlingame AL, Brown DE, Dooley DM, Smith AJ, Kagan HM, Klinman JP. PMID: 8688089.
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Peptide sequence determination by matrix-assisted laser desorption ionization employing a tandem double focusing magnetic-Orthogonal acceleration time-of-flight mass spectrometer. J Am Soc Mass Spectrom. 1996 Jan; 7(1):1-10. Medzihradszky KF, Adams GW, Burlingame AL, Bateman RH, Green MR. PMID: 24202789.
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Determination of in vivo phosphorylation sites in protein kinase C. J Biol Chem. 1995 Nov 10; 270(45):26807-12. Tsutakawa SE, Medzihradszky KF, Flint AJ, Burlingame AL, Koshland DE. PMID: 7592921.
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Mass spectrometric studies of the primary sequence and structure of bovine liver and serum amine oxidase. Methods Enzymol. 1995; 258:90-114. Adams GW, Mayer P, Medzihradszky KF, Burlingame AL. PMID: 8524166.
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Complete assignment of disulfide bonds in bovine dopamine beta-hydroxylase. Biochemistry. 1994 Sep 27; 33(38):11563-75. Robertson JG, Adams GW, Medzihradszky KF, Burlingame AL, Villafranca JJ. PMID: 7918370.
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Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression. EMBO J. 1994 Sep 15; 13(18):4390-400. Brown JD, Hann BC, Medzihradszky KF, Niwa M, Burlingame AL, Walter P. PMID: 7925282; PMCID: PMC395366.
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Characterization of protein iv-glycosylation by reversed-phase microbore liquid chromatography / electrospray mass spectrometry, complementary mobile phases, and sequential exoglycosidase digestion. J Am Soc Mass Spectrom. 1994 May; 5(5):350-8. Medzihradszky KF, Maltby DA, Hall SC, Settineri CA, Burlingame AL. PMID: 24222589.
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Primary structures for a mammalian cellular and serum copper amine oxidase. J Biol Chem. 1994 Apr 01; 269(13):9926-32. Mu D, Medzihradszky KF, Adams GW, Mayer P, Hines WM, Burlingame AL, Smith AJ, Cai D, Klinman JP. PMID: 8144587.
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Low-mass ions produced from peptides by high-energy collision-induced dissociation in tandem mass spectrometry. J Am Soc Mass Spectrom. 1993 Nov; 4(11):882-93. Falick AM, Hines WM, Medzihradszky KF, Baldwin MA, Gibson BW. PMID: 24227532.
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Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family. J Biol Chem. 1992 Oct 15; 267(29):21011-9. Wen DX, Livingston BD, Medzihradszky KF, Kelm S, Burlingame AL, Paulson JC. PMID: 1400416.
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The active site of creatine kinase. Affinity labeling of cysteine 282 with N-(2,3-epoxypropyl)-N-amidinoglycine. J Biol Chem. 1992 Feb 05; 267(4):2173-8. Buechter DD, Medzihradszky KF, Burlingame AL, Kenyon GL. PMID: 1733925.
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The primary structure of fatty-acid-binding protein from nurse shark liver. Structural and evolutionary relationship to the mammalian fatty-acid-binding protein family. Eur J Biochem. 1992 Feb 01; 203(3):327-39. Medzihradszky KF, Gibson BW, Kaur S, Yu ZH, Medzihradszky D, Burlingame AL, Bass NM. PMID: 1735421.
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Structure determination of O-linked glycopeptides by tandem mass spectrometry. Biomed Environ Mass Spectrom. 1990 Dec 05; 19(12):777-81. Medzihradszky KF, Gillece-Castro BL, Settineri CA, Townsend RR, Masiarz FR, Burlingame AL. PMID: 1708302.
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Characterization of O-glycosylation sites in recombinant B-chain of platelet-derived growth factor expressed in yeast using liquid secondary ion mass spectrometry, tandem mass spectrometry and Edman sequence analysis. Biomed Environ Mass Spectrom. 1990 Nov; 19(11):665-76. Settineri CA, Medzihradszky KF, Masiarz FR, Burlingame AL, Chu C, George-Nascimento C. PMID: 2076465.
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Artifacts in four-sector tandem mass spectrometry. Rapid Commun Mass Spectrom. 1990 Sep; 4(9):318-22. Falick AM, Medzihradszky KF, Walls FC. PMID: 2134196.
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Covalent labeling of opioid receptors with 3H-D-Ala2-Leu5-enkephalin chloromethyl ketone. II. Binding characteristics in frog brain membranes. Life Sci. 1987 Jul 13; 41(2):185-92. Simon J, Szücs M, Benyhe S, Tóth G, Hepp J, Borsodi A, Wollemann M, Medzihradszky K. PMID: 3037221.
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Met-enkephalin inhibits mineralocorticoid production in isolated human aldosteronoma cells. J Clin Endocrinol Metab. 1982 Mar; 54(3):656-60. Rácz K, Varga I, Gláz E, Kiss R, Vida S, Lada G, di Gleria K, Medzihradszky K, Lichtwald K, Vecsei P. PMID: 7056849.
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The action of enkephalins and enkephaline analogues on neuro-transmission in the isolated nicititating membrane of the cat. J Pharm Pharmacol. 1978 Jun; 30(6):394-5. Knoll J, Illés P, Medzihradszky K. PMID: 26780.
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Distribution of 3H-alpha-MSH in rat brain. Brain Res Bull. 1976 Jan-Feb; 1(1):19-26. Kastin AJ, Nissen C, Nikolics K, Medzihradszky K, Coy DH, Teplan I, Schally AV. PMID: 974794.
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[Synthesis of tritium-labeled alpha-MSH using the intermediate dibromo-alpha-MSH]. Strahlentherapie Sonderb. 1975; 74:282-5. Nikolics K, Teplán I, Medzihradszky K. PMID: 1198654.
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