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Why simply ending animal testing isn't the answer in biomedical research. Nature. 2025 Oct; 646(8086):802-803. Lloyd KCK. PMID: 41116075.
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A consensus guide to preclinical indirect calorimetry experiments. Nat Metab. 2025 Sep; 7(9):1765-1780. Banks AS, Allison DB, Alquier T, Austad SN, Auwerx J, Ayala JE, Baur JA, Carobbio S, Churchill GA, Dall M, de Cabo R, Donato J, Dragano NRV, Elias CF, Ferrante AW, Finck BN, Galgani JE, Gerhart-Hines Z, Goodyear LJ, Grobe JL, Gupta RK, Habegger KM, Hartig SM, Hevener AL, Heymsfield SB, Holman CD, de Angelis MH, James DE, Kazak L, Kim JB, Klingenspor M, Kong X, Kooijman S, Lantier L, Lloyd KCK, Lo JC, Lodhi IJ, MacLean PS, McGuinness OP, Medina-Gómez G, Mirmira RG, Morrison CD, Morton GJ, Müller TD, Ogawa Y, Pajuelo-Reguera D, Potthoff MJ, Qi N, Reitman ML, Rensen PCN, Rozman J, Rutkowsky JM, Sakamoto K, Scherer PE, Schwartz GJ, Sedlacek R, Selloum M, Shaikh SR, Chen S, Shulman GI, Škop V, Soukas AA, Speakman JR, Spiegelman BM, Steinberg GR, Svensson KJ, Thyfault JP, Tiganis T, Titchenell PM, Turner N, Velloso LA, Vidal-Puig A, Ward CS, Williams AS, Wolfrum C, Xu AW, Xu Y, Zierath JR, International Indirect Calorimetry Consensus Committee (IICCC). PMID: 40993210; PMCID: PMC12974399.
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Radiosynthesis and Preclinical Evaluation of a Carbon-11 Labeled Phosphodiesterase 7 Inhibitor for PET Neuroimaging. ACS Med Chem Lett. 2025 Sep 11; 16(9):1835-1843. Xiao Z, Sun J, Fujinaga M, Wei H, Zhao C, Haider A, Van R, Kuang S, Yamasaki T, Zhang Y, Rong J, Hu K, Chen J, Leon EC, Mori W, Xie L, Wei J, Xu Y, Shao Y, Zhang HT, Xu Y, Ran C, Lloyd KK, Wang L, Zhang MR, Liang SH. PMID: 40959257; PMCID: PMC12434536.
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Do organisms need an impact factor? Citations of key biological resources including model organisms reveal usage patterns and impact. PLoS One. 2025; 20(8):e0327344. Piekniewska A, Roelandse M, Lloyd KCK, Korf I, Voss SR, de Castro G, Magnani DM, Varga Z, James-Zorn C, Horb M, Grethe JS, Bandrowski A. PMID: 40802618; PMCID: PMC12349098.
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Protect the integrity of the US National Institutes of Health. Nature. 2025 Jul; 643(8074):1191. Kent Lloyd KC, Johnston KC, Kelley B. PMID: 40702218.
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Ocular Phenotyping of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes. Invest Ophthalmol Vis Sci. 2025 06 02; 66(6):64. Hang A, Shao A, Shea M, Roux MJ, Imai-Leonard DM, Adams DJ, Amano T, Amarie OV, Berberovic Z, Bour R, Bower L, Leonard BC, Brown SD, Cho SY, Clementson-Mobbs S, D'Souza AJ, Dickinson M, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Heaney J, Hérault Y, Hrabe de Angelis M, Hsu CW, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Seavitt JR, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Sorg T, Stewart M, Tamura M, Tolentino H, Udensi U, Wells S, Wurst W, Yoshiki A, Meziane H, Yiu G, Sieving PA, Lanoue L, Lloyd KCK, McKerlie C, Moshiri A, International Mouse Phenotyping Consortium (IMPC). PMID: 40548636; PMCID: PMC12186831.
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Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):7. Briere A, Vo P, Yang B, Adams D, Amano T, Amarie O, Berberovic Z, Bower L, Brown SDM, Burrill S, Cho SY, Clementson-Mobbs S, D'souza A, Eskandarian M, Flenniken AM, Fuchs H, Gailus-Durner V, Hérault Y, Hrabe de Angelis M, Jin S, Joynson R, Kang YK, Kim H, Masuya H, Meziane H, Nam KH, Noh H, Nutter LMJ, Palkova M, Prochazka J, Raishbrook MJ, Riet F, Salazar J, Sedlacek R, Selloum M, Seo KY, Seong JK, Shin HS, Shiroishi T, Stewart M, Svenson K, Tamura M, Tolentino H, Wells S, Wurst W, Yoshiki A, Lanoue L, Lloyd KCK, Leonard BC, Roux MJ, McKerlie C, Moshiri A, International Mouse Phenotyping Consortium. PMID: 40323269; PMCID: PMC12060066.
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Clic6 Deficiency Triggers Aberrant Apical Microvilli in RPE. Invest Ophthalmol Vis Sci. 2025 May 01; 66(5):44. Park S, Suvarnpradip N, Kasiri N, Yiu G, Thomasy SM, Imai DM, Lloyd KCK, Leonard BC, Moshiri A. PMID: 40434344; PMCID: PMC12126129.
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Severe Acute Respiratory Syndrome Coronavirus 2 Variant Infection Dynamics and Pathogenesis in Transgenic K18-hACE2 and Inbred Immunocompetent C57BL/6J Mice. Viruses. 2025 03 30; 17(4). Liu H, Ramirez BM, Wong TS, Weiss CM, Lloyd KCK, Gong Q, Coffey LL. PMID: 40284943; PMCID: PMC12031173.
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IMPC impact on preclinical mouse models. Mamm Genome. 2025 Jun; 36(2):384-389. Hölter SM, Cacheiro P, Smedley D, Kent Lloyd KC. . PMID: 39820486; PMCID: PMC12129675.
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Exploring the role of peripheral nerves in trauma-induced heterotopic ossification. JBMR Plus. 2025 Jan; 9(1):ziae155. Pereira CT, Adams SH, Lloyd KCK, Knotts TA, James AW, Price TJ, Levi B. PMID: 39677925; PMCID: PMC11646309.
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The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system. Mamm Genome. 2024 Dec; 35(4):524-536. Agca Y, Amos-Landgraf J, Araiza R, Brennan J, Carlson C, Ciavatta D, Clary D, Franklin C, Korf I, Lutz C, Magnuson T, de Villena FP, Mirochnitchenko O, Patel S, Port D, Reinholdt L, Lloyd KCK. PMID: 39304538; PMCID: PMC11522152.
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Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome. Mamm Genome. 2024 Dec; 35(4):537-543. Lloyd KCK. PMID: 39254744; PMCID: PMC11522054.
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The mouse metabolic phenotyping center (MMPC) live consortium: an NIH resource for in vivo characterization of mouse models of diabetes and obesity. Mamm Genome. 2024 Dec; 35(4):485-496. Laughlin M, McIndoe R, Adams SH, Araiza R, Ayala JE, Kennedy L, Lanoue L, Lantier L, Macy J, Malabanan E, McGuinness OP, Perry R, Port D, Qi N, Elias CF, Shulman GI, Wasserman DH, Lloyd KCK. PMID: 39191872; PMCID: PMC11522164.
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Improving laboratory animal genetic reporting: LAG-R guidelines. Nat Commun. 2024 Jul 02; 15(1):5574. Teboul L, Amos-Landgraf J, Benavides FJ, Birling MC, Brown SDM, Bryda E, Bunton-Stasyshyn R, Chin HJ, Crispo M, Delerue F, Dobbie M, Franklin CL, Fuchtbauer EM, Gao X, Golzio C, Haffner R, Hérault Y, Hrabe de Angelis M, Lloyd KCK, Magnuson TR, Montoliu L, Murray SA, Nam KH, Nutter LMJ, Pailhoux E, Pardo Manuel de Villena F, Peterson K, Reinholdt L, Sedlacek R, Seong JK, Shiroishi T, Smith C, Takeo T, Tinsley L, Vilotte JL, Warming S, Wells S, Whitelaw CB, Yoshiki A, Asian Mouse Mutagenesis Resource Association, CELPHEDIA infrastructure, INFRAFRONTIER consortium, International Mammalian Genome Society, International Mouse Phenotyping Consortium, International Society for Transgenic Technologies, Mutant Mouse Resource and Research Centers, Phenomics Australia, RRRC- Rat Resource and Research Center, Pavlovic G. PMID: 38956430; PMCID: PMC11220107.
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Sexual Dimorphism of the Mouse Plasma Metabolome Is Associated with Phenotypes of 30 Gene Knockout Lines. Metabolites. 2023 Aug 15; 13(8). Zhang Y, Barupal DK, Fan S, Gao B, Zhu C, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KCK, Fiehn O. PMID: 37623890; PMCID: PMC10456929.
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Vigilance, arousal, and acetylcholine: Optimal control of attention in a simple detection task. PLoS Comput Biol. 2022 10; 18(10):e1010642. Chebolu S, Dayan P, Lloyd K. PMID: 36315594; PMCID: PMC9648841.
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The GA4GH Phenopacket schema defines a computable representation of clinical data. Nat Biotechnol. 2022 Jun; 40(6):817-820. Jacobsen JOB, Baudis M, Baynam GS, Beckmann JS, Beltran S, Buske OJ, Callahan TJ, Chute CG, Courtot M, Danis D, Elemento O, Essenwanger A, Freimuth RR, Gargano MA, Groza T, Hamosh A, Harris NL, Kaliyaperumal R, Lloyd KCK, Khalifa A, Krawitz PM, Köhler S, Laraway BJ, Lehväslaiho H, Matalonga L, McMurry JA, Metke-Jimenez A, Mungall CJ, Munoz-Torres MC, Ogishima S, Papakonstantinou A, Piscia D, Pontikos N, Queralt-Rosinach N, Roos M, Sass J, Schofield PN, Seelow D, Siapos A, Smedley D, Smith LD, Steinhaus R, Sundaramurthi JC, Swietlik EM, Thun S, Vasilevsky NA, Wagner AH, Warner JL, Weiland C, GAGH Phenopacket Modeling Consortium, Haendel MA, Robinson PN. PMID: 35705716; PMCID: PMC9363006.
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The Mutant Mouse Resource and Research Center (MMRRC): the NIH-supported National Public Repository and Distribution Archive of Mutant Mouse Models in the USA. Mamm Genome. 2022 03; 33(1):203-212. Amos-Landgraf J, Franklin C, Godfrey V, Grieder F, Grimsrud K, Korf I, Lutz C, Magnuson T, Mirochnitchenko O, Patel S, Reinholdt L, Lloyd KCK. PMID: 34313795; PMCID: PMC8314026.
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Generation of desminopathy in rats using CRISPR-Cas9. J Cachexia Sarcopenia Muscle. 2020 10; 11(5):1364-1376. Langer HT, Mossakowski AA, Willis BJ, Grimsrud KN, Wood JA, Lloyd KCK, Zbinden-Foncea H, Baar K. PMID: 32893996; PMCID: PMC7567154.
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DNA fragmentation index (DFI) as a measure of sperm quality and fertility in mice. Sci Rep. 2020 03 02; 10(1):3833. Li MW, Lloyd KCK. PMID: 32123279; PMCID: PMC7052244.
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Soft windowing application to improve analysis of high-throughput phenotyping data. Bioinformatics. 2020 03 01; 36(5):1492-1500. Haselimashhadi H, Mason JC, Munoz-Fuentes V, López-Gómez F, Babalola K, Acar EF, Kumar V, White J, Flenniken AM, King R, Straiton E, Seavitt JR, Gaspero A, Garza A, Christianson AE, Hsu CW, Reynolds CL, Lanza DG, Lorenzo I, Green JR, Gallegos JJ, Bohat R, Samaco RC, Veeraragavan S, Kim JK, Miller G, Fuchs H, Garrett L, Becker L, Kang YK, Clary D, Cho SY, Tamura M, Tanaka N, Soo KD, Bezginov A, About GB, Champy MF, Vasseur L, Leblanc S, Meziane H, Selloum M, Reilly PT, Spielmann N, Maier H, Gailus-Durner V, Sorg T, Hiroshi M, Yuichi O, Heaney JD, Dickinson ME, Wolfgang W, Tocchini-Valentini GP, Lloyd KCK, McKerlie C, Seong JK, Yann H, de Angelis MH, Brown SDM, Smedley D, Flicek P, Mallon AM, Parkinson H, Meehan TF. PMID: 31591642; PMCID: PMC7115897.
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The Deep Genome Project. Genome Biol. 2020 02 03; 21(1):18. Lloyd KCK, Adams DJ, Baynam G, Beaudet AL, Bosch F, Boycott KM, Braun RE, Caulfield M, Cohn R, Dickinson ME, Dobbie MS, Flenniken AM, Flicek P, Galande S, Gao X, Grobler A, Heaney JD, Herault Y, de Angelis MH, Lupski JR, Lyonnet S, Mallon AM, Mammano F, MacRae CA, McInnes R, McKerlie C, Meehan TF, Murray SA, Nutter LMJ, Obata Y, Parkinson H, Pepper MS, Sedlacek R, Seong JK, Shiroishi T, Smedley D, Tocchini-Valentini G, Valle D, Wang CL, Wells S, White J, Wurst W, Xu Y, Brown SDM. PMID: 32008577; PMCID: PMC6996159.
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Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice. Dev Biol. 2020 02 15; 458(2):141-152. Kwon YS, Tham A, Lopez AJ, Edwards S, Woods S, Chen J, Wong-Fortunato J, Quiroz Alonso A, Javier S, Au I, Clarke M, Humpal D, Lloyd KCK, Thomasy S, Murphy C, Glaser TM, Moshiri A. PMID: 31634437; PMCID: PMC6995765.
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Genome-wide screening of mouse knockouts reveals novel genes required for normal integumentary and oculocutaneous structure and function. Sci Rep. 2019 08 01; 9(1):11211. Moore BA, Flenniken AM, Clary D, Moshiri AS, Nutter LMJ, Berberovic Z, Owen C, Newbigging S, Adissu H, Eskandarian M, McKerlie C, International Mouse Phenotyping Consortium, Thomasy SM, Lloyd KCK, Murphy CJ, Moshiri A. PMID: 31371754; PMCID: PMC6672016.
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New models for human disease from the International Mouse Phenotyping Consortium. Mamm Genome. 2019 06; 30(5-6):143-150. Cacheiro P, Haendel MA, Smedley D, International Mouse Phenotyping Consortium and the Monarch Initiative. PMID: 31127358; PMCID: PMC6606664.
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A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium. Metabolites. 2019 May 22; 9(5). Barupal DK, Zhang Y, Shen T, Fan S, Roberts BS, Fitzgerald P, Wancewicz B, Valdiviez L, Wohlgemuth G, Byram G, Choy YY, Haffner B, Showalter MR, Vaniya A, Bloszies CS, Folz JS, Kind T, Flenniken AM, McKerlie C, Nutter LMJ, Lloyd KC, Fiehn O. PMID: 31121816; PMCID: PMC6571919.
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Generating mouse models for biomedical research: technological advances. Dis Model Mech. 2019 01 08; 12(1). Gurumurthy CB, Lloyd KCK. PMID: 30626588; PMCID: PMC6361157.
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Development of outbred CD1 mouse colonies with distinct standardized gut microbiota profiles for use in complex microbiota targeted studies. Sci Rep. 2018 07 04; 8(1):10107. Hart ML, Ericsson AC, Lloyd KCK, Grimsrud KN, Rogala AR, Godfrey VL, Nielsen JN, Franklin CL. PMID: 29973630; PMCID: PMC6031694.
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Efficient mouse genome engineering by CRISPR-EZ technology. Nat Protoc. 2018 06; 13(6):1253-1274. Modzelewski AJ, Chen S, Willis BJ, Lloyd KCK, Wood JA, He L. PMID: 29748649; PMCID: PMC6296855.
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A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice. Invest Ophthalmol Vis Sci. 2018 05 01; 59(6):2252-2261. Moore BA, Roux MJ, Sebbag L, Cooper A, Edwards SG, Leonard BC, Imai DM, Griffey S, Bower L, Clary D, Lloyd KCK, Hérault Y, Thomasy SM, Murphy CJ, Moshiri A. PMID: 29847629; PMCID: PMC5935295.
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Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". Nat Methods. 2018 04; 15(4):235-236. Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M. PMID: 29600991.
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Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun. 2018 01 18; 9(1):288. Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H, IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M. PMID: 29348434; PMCID: PMC5773596.
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Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral halitosis. Nat Genet. 2018 01; 50(1):120-129. Pol A, Renkema GH, Tangerman A, Winkel EG, Engelke UF, de Brouwer APM, Lloyd KC, Araiza RS, van den Heuvel L, Omran H, Olbrich H, Oude Elberink M, Gilissen C, Rodenburg RJ, Sass JO, Schwab KO, Schäfer H, Venselaar H, Sequeira JS, Op den Camp HJM, Wevers RA. PMID: 29255262; PMCID: PMC5742538.
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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 11 01; 77(21):e62-e66. Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. PMID: 29092942; PMCID: PMC5738926.
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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nat Commun. 2017 10 12; 8(1):886. Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, Kelsey L, International Mouse Phenotyping Consortium, Tocchini-Valentini GP, Gao X, Bradley A, Skarnes WC, Moore M, Beaudet AL, Justice MJ, Seavitt J, Dickinson ME, Wurst W, de Angelis MH, Herault Y, Wakana S, Nutter LMJ, Flenniken AM, McKerlie C, Murray SA, Svenson KL, Braun RE, West DB, Lloyd KCK, Adams DJ, White J, Karp N, Flicek P, Smedley D, Meehan TF, Parkinson HE, Teboul LM, Wells S, Steel KP, Mallon AM, Brown SDM. PMID: 29026089; PMCID: PMC5638796.
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Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun. 2017 06 26; 8:15475. Karp NA, Mason J, Beaudet AL, Benjamini Y, Bower L, Braun RE, Brown SDM, Chesler EJ, Dickinson ME, Flenniken AM, Fuchs H, Angelis MH, Gao X, Guo S, Greenaway S, Heller R, Herault Y, Justice MJ, Kurbatova N, Lelliott CJ, Lloyd KCK, Mallon AM, Mank JE, Masuya H, McKerlie C, Meehan TF, Mott RF, Murray SA, Parkinson H, Ramirez-Solis R, Santos L, Seavitt JR, Smedley D, Sorg T, Speak AO, Steel KP, Svenson KL, International Mouse Phenotyping Consortium, Wakana S, West D, Wells S, Westerberg H, Yaacoby S, White JK. PMID: 28650954; PMCID: PMC5490203.
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Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet. 2017 Aug; 49(8):1231-1238. Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, Greenaway S, Sneddon D, Morgan H, Codner GF, Stewart ME, Brown J, Horner N, International Mouse Phenotyping Consortium, Haendel M, Washington N, Mungall CJ, Reynolds CL, Gallegos J, Gailus-Durner V, Sorg T, Pavlovic G, Bower LR, Moore M, Morse I, Gao X, Tocchini-Valentini GP, Obata Y, Cho SY, Seong JK, Seavitt J, Beaudet AL, Dickinson ME, Herault Y, Wurst W, de Angelis MH, Lloyd KCK, Flenniken AM, Nutter LMJ, Newbigging S, McKerlie C, Justice MJ, Murray SA, Svenson KL, Braun RE, White JK, Bradley A, Flicek P, Wells S, Skarnes WC, Adams DJ, Parkinson H, Mallon AM, Brown SDM, Smedley D. PMID: 28650483; PMCID: PMC5546242.
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Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev. 2017 06 15; 31(12):1243-1256. Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Huang E, Lloyd K, Duan Y, Wang J, Liu G, Chen X. PMID: 28747430; PMCID: PMC5558926.
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Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Invest Ophthalmol Vis Sci. 2017 03 01; 58(3):1709-1718. Moshiri A, Humpal D, Leonard BC, Imai DM, Tham A, Bower L, Clary D, Glaser TM, Lloyd KC, Murphy CJ. PMID: 28324111; PMCID: PMC5361582.
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Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Science. 2017 02 10; 355(6325). Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L. PMID: 28082412; PMCID: PMC6138252.
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Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res. 2017 Apr; 26(2):263-277. Jung CJ, Zhang J, Trenchard E, Lloyd KC, West DB, Rosen B, de Jong PJ. PMID: 27905063; PMCID: PMC5350237.
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High-throughput discovery of novel developmental phenotypes. Nature. 2016 09 22; 537(7621):508-514. Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, International Mouse Phenotyping Consortium, Jackson Laboratory, Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris (ICS), Charles River Laboratories, MRC Harwell, Toronto Centre for Phenogenomics, Wellcome Trust Sanger Institute, RIKEN BioResource Center, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA. PMID: 27626380; PMCID: PMC5295821.
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Animal-based studies will be essential for precision medicine. Sci Transl Med. 2016 08 17; 8(352):352ed12. Lloyd KC, Robinson PN, MacRae CA. PMID: 27535618.
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Safety out of control: dopamine and defence. Behav Brain Funct. 2016 May 23; 12(1):15. Lloyd K, Dayan P. PMID: 27216176; PMCID: PMC4878001.
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Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 2016 Feb; 12(2):e1005691. West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC. PMID: 26839965; PMCID: PMC4739719.
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Precision medicine: an opportunity for a paradigm shift in veterinary medicine. J Am Vet Med Assoc. 2016 Jan 01; 248(1):45-8. Lloyd KC, Khanna C, Hendricks W, Trent J, Kotlikoff M. PMID: 26684088; PMCID: PMC4996120.
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Comment on "One health, one literature: Weaving together veterinary and medical research". Sci Transl Med. 2015 Dec 09; 7(317):317le3. Lloyd KC, McKerlie C, Seong JK, Neff F. PMID: 26659567.
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Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation. PLoS One. 2015; 10(8):e0134155. Kirov JV, Adkisson M, Nava AJ, Cipollone A, Willis B, Engelhard EK, Lloyd KC, de Jong P, West DB. PMID: 26275310; PMCID: PMC4537176.
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Precision medicine: Look to the mice. Science. 2015 Jul 24; 349(6246):390. Lloyd KC, Meehan T, Beaudet A, Murray S, Svenson K, McKerlie C, West D, Morse I, Parkinson H, Brown S, Mallon AM, Moore M. PMID: 26206923; PMCID: PMC4960978.
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Reproducibility: use mouse biobanks or lose them. Nature. 2015 Jun 11; 522(7555):151-3. Lloyd K, Franklin C, Lutz C, Magnuson T. PMID: 26062496; PMCID: PMC4636083.
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Applying the ARRIVE Guidelines to an In Vivo Database. PLoS Biol. 2015 May; 13(5):e1002151. Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer V, Matthews P, Melvin DG, Wells S, Flenniken AM, Masuya H, Wakana S, White JK, Lloyd KC, Reynolds CL, Paylor R, West DB, Svenson KL, Chesler EJ, de Angelis MH, Tocchini-Valentini GP, Sorg T, Herault Y, Parkinson H, Mallon AM, Brown SD. PMID: 25992600; PMCID: PMC4439173.
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A lacZ reporter gene expression atlas for 313 adult KOMP mutant mouse lines. Genome Res. 2015 Apr; 25(4):598-607. West DB, Pasumarthi RK, Baridon B, Djan E, Trainor A, Griffey SM, Engelhard EK, Rapp J, Li B, de Jong PJ, Lloyd KC. PMID: 25591789; PMCID: PMC4381530.
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Rescue of germline transmission from chimeras by IVF after sperm analysis. Transgenic Res. 2015 Feb; 24(1):99-108. Li MW, Willis BJ, Evans KD, Araiza RS, Lee AY, Lloyd KC. PMID: 25080098; PMCID: PMC4276497.
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Conditional targeting of Ispd using paired Cas9 nickase and a single DNA template in mice. FEBS Open Bio. 2014; 4:637-42. Lee AY, Lloyd KC. PMID: 25161872; PMCID: PMC4141200.
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IVF recovery of mutant mouse lines using sperm cryopreserved with mtg in cryovials. Cryo Letters. 2014 Mar-Apr; 35(2):145-53. Li MW, Vallelunga JM, Kinchen KL, Rink KL, Zarrabi J, Shamamian AO, Lloyd KC. PMID: 24869647; PMCID: PMC4201379.
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Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. Cryobiology. 2014 Feb; 68(1):12-7. Takeo T, Fukumoto K, Kondo T, Haruguchi Y, Takeshita Y, Nakamuta Y, Tsuchiyama S, Yoshimoto H, Shimizu N, Li MW, Kinchen K, Vallelunga J, Lloyd KC, Nakagata N. PMID: 24201107; PMCID: PMC4140441.
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Sestrin-2, a repressor of PDGFRβ signalling, promotes cigarette-smoke-induced pulmonary emphysema in mice and is upregulated in individuals with COPD. Dis Model Mech. 2013 Nov; 6(6):1378-87. Heidler J, Fysikopoulos A, Wempe F, Seimetz M, Bangsow T, Tomasovic A, Veit F, Scheibe S, Pichl A, Weisel F, Lloyd KC, Jaksch P, Klepetko W, Weissmann N, von Melchner H. PMID: 24046361; PMCID: PMC3820261.
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Combining sperm plug genotyping and coat color chimerism predicts germline transmission. Transgenic Res. 2013 Dec; 22(6):1265-72. Lee AY, Evans K, Willis B, Lloyd KC. PMID: 23860911; PMCID: PMC3838463.
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Safety, efficacy and efficiency of laser-assisted IVF in subfertile mutant mouse strains. Reproduction. 2013 Mar 01; 145(3):245-54. Li MW, Kinchen KL, Vallelunga JM, Young DL, Wright KD, Gorano LN, Wasson K, Lloyd KC. PMID: 23315689; PMCID: PMC3738198.
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High osmolality vitrification: a new method for the simple and temperature-permissive cryopreservation of mouse embryos. PLoS One. 2013; 8(1):e49316. Mochida K, Hasegawa A, Li MW, Fray MD, Kito S, Vallelunga JM, Lloyd KC, Yoshiki A, Obata Y, Ogura A. PMID: 23341870; PMCID: PMC3547031.
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The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012 Oct; 23(9-10):580-6. Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. PMID: 22968824; PMCID: PMC3463800.
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Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. 2012 Dec 01; 21(23):5147-58. Song L, Shan Y, Lloyd KC, Cortopassi GA. PMID: 22949510; PMCID: PMC3607469.
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Centralized mouse repositories. Mamm Genome. 2012 Oct; 23(9-10):559-71. Donahue LR, Hrabe de Angelis M, Hagn M, Franklin C, Lloyd KC, Magnuson T, McKerlie C, Nakagata N, Obata Y, Read S, Wurst W, Hörlein A, Davisson MT. PMID: 22945696; PMCID: PMC3709583.
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NIH Mouse Metabolic Phenotyping Centers: the power of centralized phenotyping. Mamm Genome. 2012 Oct; 23(9-10):623-31. Laughlin MR, Lloyd KC, Cline GW, Wasserman DH, Mouse Metabolic Phenotyping Centers Consortium. PMID: 22940748; PMCID: PMC3738176.
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Mutant mice derived by ICSI of evaporatively dried spermatozoa exhibit expected phenotype. Reproduction. 2012 Apr; 143(4):449-53. Li MW, Baridon B, Trainor A, Djan E, Koehne A, Griffey SM, Biggers JD, Toner M, Lloyd KC. PMID: 22274886; PMCID: PMC3738174.
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A knockout mouse resource for the biomedical research community. Ann N Y Acad Sci. 2011 Dec; 1245:24-6. Lloyd KC. PMID: 22211970; PMCID: PMC4070945.
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Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18696-701. Yang RY, Yu L, Graham JL, Hsu DK, Lloyd KC, Havel PJ, Liu FT. PMID: 21969596; PMCID: PMC3219109.
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The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011 Feb; 10(1):55-65. Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. PMID: 21040401; PMCID: PMC4157392.
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Effect of ICSI on gene expression and development of mouse preimplantation embryos. Hum Reprod. 2010 Dec; 25(12):3012-24. Giritharan G, Li MW, Di Sebastiano F, De Sebastiano F, Esteban FJ, Horcajadas JA, Lloyd KC, Donjacour A, Maltepe E, Rinaudo PF. PMID: 20889529; PMCID: PMC2989873.
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Rederivation of transgenic mice from iPS cells derived from frozen tissue. Transgenic Res. 2011 Feb; 20(1):167-75. Lee AY, Lloyd KC. PMID: 20397045; PMCID: PMC3018598.
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Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature. 2010 Apr 29; 464(7293):1376-80. Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B. PMID: 20393464.
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Decreased growth factor expression through RNA interference inhibits development of mouse preimplantation embryos. Comp Med. 2009 Aug; 59(4):331-8. Dadi TD, Li MW, Lloyd KC. PMID: 19712572; PMCID: PMC2779207.
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Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods. 2009 Jul; 6(7):493-5. Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR, Lloyd KC, Bradley A, Skarnes WC. PMID: 19525957; PMCID: PMC3555078.
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Assessment of three generations of mice derived by ICSI using freeze-dried sperm. Zygote. 2009 Aug; 17(3):239-51. Li MW, Willis BJ, Griffey SM, Spearow JL, Lloyd KC. PMID: 19416557; PMCID: PMC5006740.
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Further optimization of mouse spermatozoa evaporative drying techniques. Cryobiology. 2009 Aug; 59(1):113-5. Elmoazzen HY, Lee GY, Li MW, McGinnis LK, Lloyd KC, Toner M, Biggers JD. PMID: 19375415; PMCID: PMC2722843.
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Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4507-12. Barros CS, Calabrese B, Chamero P, Roberts AJ, Korzus E, Lloyd K, Stowers L, Mayford M, Halpain S, Müller U. PMID: 19240213; PMCID: PMC2657442.
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Rotationally oscillating drill (Ros-Drill) for mouse ICSI without using mercury. Mol Reprod Dev. 2008 Dec; 75(12):1744-51. Ergenc AF, Li MW, Toner M, Biggers JD, Lloyd KC, Olgac N. PMID: 18437690; PMCID: PMC5006739.
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Public health education at the University of California, Davis: past, present, and future programs. J Vet Med Educ. 2008; 35(2):219-24. Hird DW, Lloyd KC, McCurdy SA, Schenker MB, Troidl JJ, Kass PH. PMID: 18723807.
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The scientific component of residency training. J Vet Med Educ. 2008; 35(1):53-7. Lloyd KC. PMID: 18339958.
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Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation. J Biol Chem. 2007 Dec 21; 282(51):37053-63. Huang L, Yu YY, Kirschke CP, Gertz ER, Lloyd KK. PMID: 17954933.
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Phenotypic analysis of C57BL/6J and FVB/NJ mice generated using evaporatively dried spermatozoa. Comp Med. 2007 Oct; 57(5):469-75. Li MW, Biggers JD, Toner M, Griffey SM, Lloyd KC. PMID: 17974129.
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Long-term storage of mouse spermatozoa after evaporative drying. Reproduction. 2007 May; 133(5):919-29. Li MW, Biggers JD, Elmoazzen HY, Toner M, McGinnis L, Lloyd KC. PMID: 17616722.
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Disruption of Rxra gene in thymocytes and T lymphocytes modestly alters lymphocyte frequencies, proliferation, survival and T helper type 1/type 2 balance. Immunology. 2007 Aug; 121(4):484-98. Stephensen CB, Borowsky AD, Lloyd KC. PMID: 17433077; PMCID: PMC2265968.
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EGF and TGF-alpha supplementation enhances development of cloned mouse embryos. Cloning Stem Cells. 2007; 9(3):315-26. Dadi TD, Li MW, Lloyd KC. PMID: 17907942.
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Development of mouse embryos after immunoneutralization of mitogenic growth factors mimics that of cloned embryos. Comp Med. 2006 Jun; 56(3):188-95. Dadi TD, Li MW, Lloyd KC. PMID: 16774127.
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Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. Oncogene. 2006 Sep 14; 25(41):5664-72. Jackson-Fisher AJ, Bellinger G, Shum E, Duong JK, Perkins AS, Gassmann M, Muller W, Kent Lloyd KC, Stern DF. PMID: 16652155.
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Targeted disruption of the murine CCK1 receptor gene reduces intestinal lipid-induced feedback inhibition of gastric function. Am J Physiol Gastrointest Liver Physiol. 2006 Jul; 291(1):G156-62. Whited KL, Thao D, Lloyd KC, Kopin AS, Raybould HE. PMID: 16574983.
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The role of neuregulin-ErbB4 interactions on the proliferation and organization of cells in the subventricular zone. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1930-5. Ghashghaei HT, Weber J, Pevny L, Schmid R, Schwab MH, Lloyd KC, Eisenstat DD, Lai C, Anton ES. PMID: 16446434; PMCID: PMC1413654.
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Apolipoprotein A-IV is involved in detection of lipid in the rat intestine. J Physiol. 2005 Dec 15; 569(Pt 3):949-58. Whited KL, Lu D, Tso P, Kent Lloyd KC, Raybould HE. PMID: 16239275; PMCID: PMC1464270.
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Movement disorders in the Hfe knockout mouse. Nutr Neurosci. 2005 Aug; 8(4):239-44. Golub MS, Germann SL, Araiza RS, Reader JR, Griffey SM, Lloyd KC. PMID: 16491649.
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Synapses form in skeletal muscles lacking neuregulin receptors. Science. 2005 Jun 24; 308(5730):1920-3. Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, Lloyd KC, Mueller U, Brenner HR. PMID: 15976301.
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N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery. Gastroenterology. 2005 Jun; 128(7):2009-19. Patierno S, Zellalem W, Ho A, Parsons CG, Lloyd KC, Tonini M, Sternini C. PMID: 15940633.
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Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle. Am J Physiol Heart Circ Physiol. 2005 Sep; 289(3):H1153-60. García-Rivello H, Taranda J, Said M, Cabeza-Meckert P, Vila-Petroff M, Scaglione J, Ghio S, Chen J, Lai C, Laguens RP, Lloyd KC, Hertig CM. PMID: 15863464.
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The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem. 2004 Dec; 91(6):1302-11. Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH. PMID: 15584907.
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Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 2004 Dec; 7(12):1319-28. Anton ES, Ghashghaei HT, Weber JL, McCann C, Fischer TM, Cheung ID, Gassmann M, Messing A, Klein R, Schwab MH, Lloyd KC, Lai C. PMID: 15543145.
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The knockout mouse project. Nat Genet. 2004 Sep; 36(9):921-4. Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B. PMID: 15340423; PMCID: PMC2716027.
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Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res. 2004 Aug 12; 153(1):159-70. Golub MS, Germann SL, Lloyd KC. PMID: 15219717.
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Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor alpha. Arterioscler Thromb Vasc Biol. 2004 Jun; 24(6):1055-61. Villablanca A, Lubahn D, Shelby L, Lloyd K, Barthold S. PMID: 15117737.
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Expression levels of EGF, TGF-alpha, and EGF-R are significantly reduced in pre-implantation cloned mouse embryos. Cloning Stem Cells. 2004; 6(3):267-83. Dadi TD, Li MW, Lloyd KC. PMID: 15671673.
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Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003 Nov; 130(21):5257-68. Long W, Wagner KU, Lloyd KC, Binart N, Shillingford JM, Hennighausen L, Jones FE. PMID: 12954715.
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Frozen sperm as an alternative to shipping live mice. Contemp Top Lab Anim Sci. 2003 Sep; 42(5):8-11. Awasthi PR, French CF, Sztein J, Bedigian R, Sharp JJ, Lloyd KC. PMID: 14510517.
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Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains. Comp Med. 2003 Jun; 53(3):265-9. Li MW, McGinnis L, Zhu L, Lawitts J, Biggers J, Lloyd KC. PMID: 12868571.
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Acid inhibition by intestinal nutrients mediated by CCK-A receptors but not plasma CCK. Am J Physiol Gastrointest Liver Physiol. 2001 Oct; 281(4):G924-30. Lloyd KC, Wang J, Solomon TE. PMID: 11557512.
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Duodenal loading with glucose induces fos expression in rat brain: selective blockade by devazepide. Am J Physiol. 1999 09; 277(3):R667-74. Wang L, Cardin S, Martínez V, Taché Y, Lloyd KC. PMID: 10484482.
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Calcitonin gene-related peptide and spinal afferents partly mediate postoperative colonic ileus in the rat. Surgery. 1998 May; 123(5):518-27. Zittel TT, Lloyd KC, Rothenhöfer I, Wong H, Walsh JH, Raybould HE. PMID: 9591004.
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Inhibition of sham feeding-stimulated acid secretion in dogs by immunoneutralization of gastrin. Am J Physiol. 1997 Aug; 273(2 Pt 1):G399-403. Kovacs TO, Lloyd KC, Lawson DC, Pappas TN, Walsh JH. PMID: 9277419.
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Somatostatin inhibits gastrin release and acid secretion by activating sst2 in dogs. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1481-8. Lloyd KC, Amirmoazzami S, Friedik F, Chew P, Walsh JH. PMID: 9227485.
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Candidate canine enterogastrones: acid inhibition before and after vagotomy. Am J Physiol. 1997 May; 272(5 Pt 1):G1236-42. Lloyd KC, Amirmoazzami S, Friedik F, Heynio A, Solomon TE, Walsh JH. PMID: 9176235.
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Role of gastrin/CCK-B receptors in meal-stimulated acid secretion in rats. Am J Physiol. 1997 May; 272(5 Pt 1):G1243-8. Aurang K, Spraggs CF, Jordan C, Lloyd KC. PMID: 9176236.
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Somatostatin inhibition of acid and histamine release by activation of somatostatin receptor subtype 2 receptors in rats. J Pharmacol Exp Ther. 1997 Apr; 281(1):245-52. Aurang K, Wang J, Lloyd KC. PMID: 9103503.
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Simultaneous manipulation of intestinal capacities and nutrient loads in mice. Am J Physiol. 1996 Dec; 271(6 Pt 1):G969-79. Hammond KA, Lam M, Lloyd KC, Diamond J. PMID: 8997240.
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Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells. Infect Immun. 1996 Dec; 64(12):5161-5. Qu XD, Lloyd KC, Walsh JH, Lehrer RI. PMID: 8945560; PMCID: PMC174502.
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Gastrin mediates the gastric mucosal proliferative response to feeding. Am J Physiol. 1996 Sep; 271(3 Pt 1):G470-6. Ohning GV, Wong HC, Lloyd KC, Walsh JH. PMID: 8843772.
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Monoclonal antibody to VIP: production, characterization, immunoneutralizing activity, and usefulness in cytochemical staining. Hybridoma. 1996 Apr; 15(2):133-9. Wong HC, Sternini C, Lloyd K, De Giorgio R, Walsh JH. PMID: 8743293.
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Is mammary output capacity limiting to lactational performance in mice? J Exp Biol. 1996 Feb; 199(Pt 2):337-49. Hammond KA, Lloyd KC, Diamond J. PMID: 8930000.
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Intracerebroventricular injection of somatostatin sst5 receptor agonist inhibits gastric acid secretion in rats. Eur J Pharmacol. 1996 Jan 25; 296(2):153-60. Martínez V, Coy DH, Lloyd KC, Taché Y. PMID: 8838451.
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Gastrin partially mediates insulin-induced acid secretion in dogs. Peptides. 1996; 17(4):583-7. Kovacs TO, Lloyd KC, Walsh JH. PMID: 8804065.
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Inhibitory effect of PYY on vagally stimulated acid secretion is mediated predominantly by Y1 receptors. Am J Physiol. 1996 Jan; 270(1 Pt 1):G123-7. Lloyd KC, Grandt D, Aurang K, Eysselein VE, Schimiczek M, Reeve JR. PMID: 8772509.
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Somatostatin inhibits B-cell secretion via a subtype-2 somatostatin receptor in the isolated perfused human pancreas. J Surg Res. 1995 Jul; 59(1):85-90. Moldovan S, Atiya A, Adrian TE, Kleinman RM, Lloyd K, Olthoff K, Imagawa D, Shevlin L, Coy D, Walsh J, et al. PMID: 7630142.
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Inhibition of bombesin-stimulated acid secretion by immunoneutralization of gastrin in dogs. Am J Physiol. 1995 Jan; 268(1 Pt 1):G54-8. Kovacs TO, Lloyd KC, Wong H, Walsh JH. PMID: 7840208.
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Activation of somatostatin receptor subtype 2 inhibits acid secretion in rats. Am J Physiol. 1995 Jan; 268(1 Pt 1):G102-6. Lloyd KC, Wang J, Aurang K, Grönhed P, Coy DH, Walsh JH. PMID: 7840190.
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Gastroduodenal sensory mechanisms and CCK in inhibition of gastric emptying in response to a meal. Dig Dis Sci. 1994 Dec; 39(12 Suppl):41S-43S. Raybould HE, Zittel TT, Holzer HH, Lloyd KC, Meyer JH. PMID: 7995213.
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The inhibitory role of intraislet somatostatin on glucagon secretion in the isolated perfused human pancreas. Transplant Proc. 1994 Dec; 26(6):3451-2. Brunicardi FC, Kleinman RM, Ohning G, Lloyd K, Gingerich R, Wong H, Walsh J. PMID: 7998217.
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Multiple pathways controlling acid secretion. J Gastroenterol. 1994 Jul; 29 Suppl 7:77-9. Lloyd KC, Soll AH. PMID: 7921159.
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Future directions for reductionistic research in gastric secretion and defense. J Gastroenterol. 1994 Jul; 29 Suppl 7:1-5. Lloyd KC, Soll AH. PMID: 7921137.
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Integration of postprandial function in the proximal gastrointestinal tract. Role of CCK and sensory pathways. Ann N Y Acad Sci. 1994 Mar 23; 713:143-56. Raybould HE, Lloyd KC. PMID: 8185155.
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Gut hormones in gastric function. Baillieres Clin Endocrinol Metab. 1994 Jan; 8(1):111-36. Lloyd KC. PMID: 7907860.
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Somatostatin is released in response to cholecystokinin by activation of type A CCK receptors. Peptides. 1994; 15(2):223-7. Lloyd KC, Maxwell V, Chuang CN, Wong HC, Soll AH, Walsh JH. PMID: 7911992.
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Use of the Fab fragment for immunoneutralization of somatostatin in the isolated perfused human pancreas. Am J Surg. 1994 Jan; 167(1):114-9. Kleinman R, Gingerich R, Wong H, Walsh J, Lloyd K, Ohning G, De Giorgio R, Sternini C, Brunicardi FC. PMID: 7906098.
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Effect of transamniotic administration of epidermal growth factor on fetal rabbit small intestinal nutrient transport and disaccharidase development. J Pediatr Surg. 1993 Oct; 28(10):1239-44. Buchmiller TL, Shaw KS, Chopourian HL, Lloyd KC, Gregg JP, Rivera FA, Lam ML, Diamond JM, Fonkalsrud EW. PMID: 8263680.
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Endogenous somatostatin inhibits histamine release from canine gastric mucosal cells in primary culture. Am J Physiol. 1993 Sep; 265(3 Pt 1):G521-5. Chuang CN, Tanner M, Lloyd KC, Wong H, Soll AH. PMID: 7692744.
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Ontogeny of gastric function vs the 'stress syndrome'. Equine Vet J. 1993 May; 25(3):179. Lloyd KC. PMID: 8508742.
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Duodenal lipid inhibits gastric acid secretion by vagal, capsaicin-sensitive afferent pathways in rats. Am J Physiol. 1993 Apr; 264(4 Pt 1):G659-63. Lloyd KC, Hölzer HH, Zittel TT, Raybould HE. PMID: 8476052.
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Monoclonal antibody to rat alpha-CGRP: production, characterization, and in vivo immunoneutralization activity. Hybridoma. 1993 Feb; 12(1):93-106. Wong HC, Taché Y, Lloyd KC, Yang H, Sternini C, Holzer P, Walsh JH. PMID: 8095920.
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Impaired glucose response following total pancreatectomy and islet cell autotransplantation in dogs. Transplant Proc. 1992 Dec; 24(6):3026-8. Watt PC, Ricordi C, Zeng Y, Kleinman R, Gingerich RL, Lloyd KC, Brunicardi FC. PMID: 1466043.
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Intestinal fat does not inhibit gastric function through a hormonal somatostatin mechanism in dogs. Gastroenterology. 1992 Oct; 103(4):1221-8. Lloyd KC, Maxwell V, Ohning G, Walsh JH. PMID: 1356872.
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Cholecystokinin inhibits gastric acid secretion through type "A" cholecystokinin receptors and somatostatin in rats. Am J Physiol. 1992 Sep; 263(3 Pt 1):G287-92. Lloyd KC, Raybould HE, Walsh JH. PMID: 1357976.
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Preparation of a monoclonal antibody to rat alpha-CGRP for in vivo immunoneutralization of peptides. Ann N Y Acad Sci. 1992 Jun 30; 657:525-7. Wong HC, Lloyd K, Yang H, Sternini C, Walsh JH. PMID: 1637113.
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Role of gastrin, histamine, and acetylcholine in the gastric phase of acid secretion in anesthetized rats. Am J Physiol. 1992 Apr; 262(4 Pt 1):G747-55. Lloyd KC, Raybould HE, Taché Y, Walsh JH. PMID: 1348909.
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Cholecystokinin receptor antagonist MK-329 blocks intestinal fat-induced inhibition of meal-stimulated gastric acid secretion. Gastroenterology. 1992 Jan; 102(1):131-8. Lloyd KC, Maxwell V, Kovacs TO, Miller J, Walsh JH. PMID: 1727746.
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Evidence that myenteric neurons of the gastric corpus project to both the mucosa and the external muscle: myectomy operations on the canine stomach. Cell Tissue Res. 1991 Dec; 266(3):475-81. Furness JB, Lloyd KC, Sternini C, Walsh JH. PMID: 1811878.
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Luminal glucose concentrations in the gut under normal conditions. Am J Physiol. 1990 Nov; 259(5 Pt 1):G822-37. Ferraris RP, Yasharpour S, Lloyd KC, Mirzayan R, Diamond JM. PMID: 2240224.
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Projections of substance P, vasoactive intestinal peptide and tyrosine hydroxylase immunoreactive nerve fibres in the canine intestine, with special reference to the innervation of the circular muscle. Arch Histol Cytol. 1990 May; 53(2):129-40. Furness JB, Lloyd KC, Sternini C, Walsh JH. PMID: 1695512.
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Surgical repair of collagenolytic ulcerative keratitis in the horse. Equine Vet J. 1990 Mar; 22(2):88-92. Hacker DV, Murphy CJ, Lloyd KC, Bellhorn RW, Scagliotti H. PMID: 2318187.
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Ulceration in the proximal portion of the urethra as a cause of hematuria in horses: four cases (1978-1985). J Am Vet Med Assoc. 1989 May 01; 194(9):1324-6. Lloyd KC, Wheat JD, Ryan AM, Matthews M. PMID: 2722669.
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Keratomas in horses: seven cases (1975-1986). J Am Vet Med Assoc. 1988 Oct 15; 193(8):967-70. Lloyd KC, Peterson PR, Wheat JD, Ryan AE, Clark JH. PMID: 3192482.
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Treatment of respiratory distress in a prematurely born foal. J Am Vet Med Assoc. 1988 Sep 01; 193(5):560-2. Lloyd KC, Kelly AB, Dunlop CI. PMID: 3049490.
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Adverse reaction to procaine penicillin G in horses. Aust Vet J. 1988 Jun; 65(6):181-5. Nielsen IL, Jacobs KA, Huntington PJ, Chapman CB, Lloyd KC. PMID: 3415617.
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Alternative diagnoses in the colic patient. Vet Clin North Am Equine Pract. 1988 Apr; 4(1):17-34. Lloyd KC. PMID: 3289694.
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Incomplete palmar fracture of the proximal extremity of the third metacarpal bone in horses: ten cases (1981-1986). J Am Vet Med Assoc. 1988 Mar 15; 192(6):798-803. Lloyd KC, Koblik P, Ragle C, Wheat JD, Lakritz J. PMID: 3356600.
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Pancytopenia caused by bone marrow aplasia in a horse. J Am Vet Med Assoc. 1987 Dec 01; 191(11):1462-4. Lavoie JP, Morris DD, Zinkl JG, Lloyd K, Divers TJ. PMID: 3692997.
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Therapy in two cases of neonatal foal septicaemia and meningitis with cefotaxime sodium. Equine Vet J. 1987 Mar; 19(2):151-4. Morris DD, Rutkowski J, Lloyd KC. PMID: 3569200.
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Management of a schwannoma in the larynx of a lion. J Am Vet Med Assoc. 1986 Nov 01; 189(9):1202-3. Paul-Murphy J, Lloyd K, Turrel JM, Blanchard PC, Gage L, Fowler M. PMID: 3505985.
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Surgical treatment of laryngeal ossification in a tiger. J Am Vet Med Assoc. 1986 Nov 01; 189(9):1205-6. Lloyd KC, Paul-Murphy J, Anderson C, Gage L, Wheat JD, Fowler M. PMID: 3146564.
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Diagnostic laparoscopy in the horse. J Am Vet Med Assoc. 1986 Aug 01; 189(3):289-92. Fischer AT, Lloyd KC, Carlson GP, Madigan JE. PMID: 2943716.
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Reserpine toxicosis in a horse. J Am Vet Med Assoc. 1985 May 01; 186(9):980-1. Lloyd KC, Harrison I, Tulleners E. PMID: 3997654.
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