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Bi-allelic variants in FSD1L cause retinitis pigmentosa with or without neurological involvement. Am J Hum Genet. 2026 Mar 05; 113(3):616-626. Lin S, Cancellieri F, Cao Y, Lotery AJ, Moye AR, Vaclavik V, Perren F, Poplawski AB, Schiff ER, Ullah M, Iglesias-Romero AB, Kaminska K, Jestin A, Folcher M, Wallerich S, Ribeiro MM, Hahaut V, Picelli S, Mustafi D, Tworak A, Smidak R, Li Y, Lu J, Wang M, Mahroo OA, Borooah S, Quinodoz M, Palczewski K, Webster AR, Rivolta C, Chen R, Arno G. PMID: 41720099.
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Lipid-nanoparticle-mediated base editing of the trabecular meshwork rescues glaucoma in vivo. JCI Insight. 2026 Feb 09; 11(3). Kaipa BR, Li L, Gopalakrishnan P, Du S, Felgner J, Palczewski K, Felgner P, Zode GS. PMID: 41657308; PMCID: PMC12892903.
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A combinatorial synthetic strategy for developing genome-editing protein-delivery agents targeting mouse retina. Nat Commun. 2026 02 07; 17(1). Zhang J, Holubowicz R, Smidak R, Hu Y, Du SW, Felgner JH, Palczewska G, Rodrigues Menezes C, Risaliti E, Dong Z, Ma X, Shayegan MH, Chen PZ, Xing L, Holubowicz M, Li B, Liu DR, Felgner PL, Tochtrop GP, Palczewski K. PMID: 41654520; PMCID: PMC12992809.
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Structural analysis of rhodopsin states in megabody complexes. Proc Natl Acad Sci U S A. 2026 Feb 10; 123(6):e2532336123. Salom D, Suder DS, Huang W, Wu A, Pardon E, Steyaert J, Kiser PD, Taylor DJ, Gonen S, Palczewski K. PMID: 41650224; PMCID: PMC12891041.
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Presynaptic Changes in Mouse Rod Photoreceptors During Early Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2025 Dec 01; 66(15):4. Roihuvuo E, Sturgis L, Montaser AB, Tabaka M, Choi EH, Mathew D, Makiou AS, Huttunen KM, Palczewski K, Vinberg F, Leinonen H. PMID: 41324324; PMCID: PMC12697692.
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Retinol tracing within murine neural retina reveals cell type-specific retinol transport and distribution. J Clin Invest. 2026 Feb 02; 136(3). Engfer ZJ, Palczewska G, Du SW, Zhang J, Dong Z, Menezes CR, Wang J, Shao J, Tucker BA, Mullins RF, Chen R, Kiser PD, Palczewski K. PMID: 41252217; PMCID: PMC12867154.
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Scalable purification enables high-quality virus-like particles for therapeutic translation. J Biol Chem. 2025 12; 301(12):110946. Holubowicz R, Gao F, Du SW, Rodrigues Menezes C, Zhang J, Holubowicz MW, Chen PZ, Armbrust N, Geilenkeuser J, Liu DR, Truong DJ, Westmeyer GG, Palczewska G, Palczewski K. PMID: 41241097; PMCID: PMC12753231.
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TIGER: A tdTomato in vivo genome-editing reporter mouse for investigating precision-editor delivery approaches. Proc Natl Acad Sci U S A. 2025 Sep 02; 122(35):e2506257122. Du SW, Palczewska G, Dong Z, Lauterborn JC, Kaipa BR, Yan AL, Holubowicz R, Ha S, Chen PZ, Gall CM, Zode G, Liu DR, Palczewski K. PMID: 40880534; PMCID: PMC12415246.
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Rationally Designed, Short-Acting RPE65 Inhibitors for Visual Cycle-Associated Retinopathies. J Med Chem. 2025 Aug 28; 68(16):17638-17652. Bassetto M, Hu Y, Li B, Chen X, Saraswat V, Damacio F, Smidak R, Palczewski K, Tochtrop GP, Kiser PD. PMID: 40764714; PMCID: PMC12409883.
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MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids. Proc Natl Acad Sci U S A. 2025 Apr 22; 122(16):e2425523122. Tworak A, Smidak R, Rodrigues Menezes C, Du SW, Suh S, Choi EH, Imanishi SS, Dong Z, Lewandowski D, Fong KE, Grigorean G, Pinto AFM, Xu Q, Skowronska-Krawczyk D, Blackshaw S, Imanishi Y, Palczewski K. PMID: 40249779; PMCID: PMC12036977.
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Engineered nucleocytosolic vehicles for loading of programmable editors. Cell. 2025 May 15; 188(10):2637-2655.e31. Geilenkeuser J, Armbrust N, Steinmaßl E, Du SW, Schmidt S, Binder EMH, Li Y, Warsing NW, Wendel SV, von der Linde F, Schiele EM, Niu X, Stroppel L, Berezin O, Santl TH, Orschmann T, Nelson K, Gruber C, Palczewska G, Menezes CR, Risaliti E, Engfer ZJ, Koleci N, Schmidts A, Geerlof A, Palczewski K, Westmeyer GG, Truong DJ. PMID: 40209705.
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Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction. Proc Natl Acad Sci U S A. 2025 Feb 18; 122(7):e2421722122. Tomczewski S, Curatolo A, Foik A, Wegrzyn P, Balamut B, Wielgo M, Kulesza W, Galinska A, Kordecka K, Gulati S, Fernandes H, Palczewski K, Wojtkowski M. PMID: 39946535; PMCID: PMC11848411.
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Integrin Trafficking, Fibronectin Architecture, and Glomerular Injury upon Adiponectin Receptor 1 Depletion. J Am Soc Nephrol. 2025 May 01; 36(5):825-844. Lindfors S, Schmotz C, Lewandowski D, Hau A, Saikko L, Lehtonen E, Majaniemi V, Karhe M, Naams JB, Nisen H, Tienari J, Saleem MA, Pfeil K, Bugger H, Pietiläinen KH, Mirtti T, Palczewski K, Lehtonen S. PMID: 39874092; PMCID: PMC12059104.
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Structure and self-association of Arrestin-1. J Struct Biol. 2025 Mar; 217(1):108173. Salom D, Palczewski K. PMID: 39880147; PMCID: PMC11981688.
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CryoEM structure and small-angle X-ray scattering analyses of porcine retinol-binding protein 3. Open Biol. 2025 Jan; 15(1):240180. Kaushik V, Gessa L, Kumar N, Pinkas M, Czarnocki-Cieciura M, Palczewski K, Novácek J, Fernandes H. PMID: 39837501; PMCID: PMC11750400.
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Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma. JCI Insight. 2025 Jan 21; 10(5). Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar JC, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode GS. PMID: 39836483; PMCID: PMC11949003.
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Insights into the Activation and Self-Association of Arrestin-1. Biochemistry. 2025 01 21; 64(2):364-376. Salom D, Kiser PD, Palczewski K. PMID: 39704710; PMCID: PMC11784764.
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Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations. Nat Biomed Eng. 2025 Jan; 9(1):57-78. Holubowicz R, Du SW, Felgner J, Smidak R, Choi EH, Palczewska G, Menezes CR, Dong Z, Gao F, Medani O, Yan AL, Holubowicz MW, Chen PZ, Bassetto M, Risaliti E, Salom D, Workman JN, Kiser PD, Foik AT, Lyon DC, Newby GA, Liu DR, Felgner PL, Palczewski K. PMID: 39609561; PMCID: PMC11754100.
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In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice. Proc Natl Acad Sci U S A. 2024 Nov 26; 121(48):e2416827121. Du SW, Newby GA, Salom D, Gao F, Menezes CR, Suh S, Choi EH, Chen PZ, Liu DR, Palczewski K. PMID: 39556729; PMCID: PMC11621631.
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Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma. bioRxiv. 2024 Nov 02. Kaipa BR, Kasetti R, Sundaresan Y, Li L, Yacoub S, Millar C, Cho W, Skowronska-Krawczyk D, Maddineni P, Palczewski K, Zode G. PMID: 39345520; PMCID: PMC11429981.
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The multifaceted roles of retinoids in eye development, vision, and retinal degenerative diseases. Curr Top Dev Biol. 2025; 161:235-296. Engfer ZJ, Palczewski K. PMID: 39870435.
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Identification of shared gene expression programs activated in multiple modes of torpor across vertebrate clades. Sci Rep. 2024 10 17; 14(1):24360. Weir K, Vega N, Busa VF, Sajdak B, Kallestad L, Merriman D, Palczewski K, Carroll J, Blackshaw S. PMID: 39420030; PMCID: PMC11487170.
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Retinal Proteome Profiling of Inherited Retinal Degeneration Across Three Different Mouse Models Suggests Common Drug Targets in Retinitis Pigmentosa. Mol Cell Proteomics. 2024 Nov; 23(11):100855. Montaser AB, Gao F, Peters D, Vainionpää K, Zhibin N, Skowronska-Krawczyk D, Figeys D, Palczewski K, Leinonen H. PMID: 39389360; PMCID: PMC11602984.
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Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2024 Oct 08; 121(41):e2414037121. Krishnamoorthi A, Salom D, Wu A, Palczewski K, Rentzepis PM. PMID: 39356673; PMCID: PMC11474067.
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The Impact of Nanobodies on G Protein-Coupled Receptor Structural Biology and Their Potential as Therapeutic Agents. Mol Pharmacol. 2024 Sep 17; 106(4):155-163. Salom D, Wu A, Liu CC, Palczewski K. PMID: 39107078; PMCID: PMC11413913.
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A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models. Nat Commun. 2024 Jul 15; 15(1):5943. Leinonen H, Zhang J, Occelli LM, Seemab U, Choi EH, L P Marinho LF, Querubin J, Kolesnikov AV, Galinska A, Kordecka K, Hoang T, Lewandowski D, Lee TT, Einstein EE, Einstein DE, Dong Z, Kiser PD, Blackshaw S, Kefalov VJ, Tabaka M, Foik A, Petersen-Jones SM, Palczewski K. PMID: 39009597; PMCID: PMC11251169.
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Conditional deletion of miR-204 and miR-211 in murine retinal pigment epithelium results in retinal degeneration. J Biol Chem. 2024 06; 300(6):107344. Du SW, Komirisetty R, Lewandowski D, Choi EH, Panas D, Suh S, Tabaka M, Radu RA, Palczewski K. PMID: 38705389; PMCID: PMC11140208.
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Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 05 28; 43(5):114143. Bassetto M, Kolesnikov AV, Lewandowski D, Kiser JZ, Halabi M, Einstein DE, Choi EH, Palczewski K, Kefalov VJ, Kiser PD. PMID: 38676924; PMCID: PMC11211020.
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Restoring retinal polyunsaturated fatty acid balance and retina function by targeting ceramide in AdipoR1-deficient mice. J Biol Chem. 2024 05; 300(5):107291. Lewandowski D, Gao F, Imanishi S, Tworak A, Bassetto M, Dong Z, Pinto AFM, Tabaka M, Kiser PD, Imanishi Y, Skowronska-Krawczyk D, Palczewski K. PMID: 38636661; PMCID: PMC11107370.
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Retinylidene chromophore hydrolysis from mammalian visual and non-visual opsins. J Biol Chem. 2024 03; 300(3):105678. Hong JD, Salom D, Choi EH, Du SW, Tworak A, Smidak R, Gao F, Solano YJ, Zhang J, Kiser PD, Palczewski K. PMID: 38272218; PMCID: PMC10877631.
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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nat Biotechnol. 2024 Oct; 42(10):1526-1537. An M, Raguram A, Du SW, Banskota S, Davis JR, Newby GA, Chen PZ, Palczewski K, Liu DR. PMID: 38191664; PMCID: PMC11228131.
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Sex-Specific Early Retinal Dysfunction in Mutant TDP-43 Transgenic Mice. J Alzheimers Dis. 2024; 97(2):927-937. Gao J, Leinonen H, Wang EJ, Ding M, Perry G, Palczewski K, Wang X. PMID: 38143367; PMCID: PMC11174142.
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Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses. Proc Natl Acad Sci U S A. 2023 12 12; 120(50):e2314698120. Engfer ZJ, Lewandowski D, Dong Z, Palczewska G, Zhang J, Kordecka K, Placzkiewicz J, Panas D, Foik AT, Tabaka M, Palczewski K. PMID: 38064509; PMCID: PMC10723050.
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Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain. Nat Commun. 2023 08 25; 14(1):5209. Wu A, Salom D, Hong JD, Tworak A, Watanabe K, Pardon E, Steyaert J, Kandori H, Katayama K, Kiser PD, Palczewski K. PMID: 37626045; PMCID: PMC10457330.
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Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia. Cell Rep. 2023 08 29; 42(8):112982. Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. PMID: 37585292; PMCID: PMC10530494.
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Genome editing in the treatment of ocular diseases. Exp Mol Med. 2023 08; 55(8):1678-1690. Choi EH, Suh S, Sears AE, Holubowicz R, Kedhar SR, Browne AW, Palczewski K. PMID: 37524870; PMCID: PMC10474087.
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A short story on how chromophore is hydrolyzed from rhodopsin for recycling. Bioessays. 2023 09; 45(9):e2300068. Hong JD, Palczewski K. PMID: 37454357; PMCID: PMC10614701.
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Saving eyesight, one gene at a time. Trends Mol Med. 2023 07; 29(7):484-486. Holubowicz R, Palczewski K. PMID: 37169661; PMCID: PMC10521062.
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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition. Proc Natl Acad Sci U S A. 2023 05 09; 120(19):e2221045120. Luu JC, Saadane A, Leinonen H, Choi EH, Gao F, Lewandowski D, Halabi M, Sander CL, Wu A, Wang JM, Singh R, Gao S, Lessieur EM, Dong Z, Palczewska G, Mullins RF, Peachey NS, Kiser PD, Tabaka M, Kern TS, Palczewski K. PMID: 37126699; PMCID: PMC10175720.
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In vivo imaging of the human retina using a two-photon excited fluorescence ophthalmoscope. STAR Protoc. 2023 Jun 16; 4(2):102225. Boguslawski J, Tomczewski S, Dabrowski M, Komar K, Milkiewicz J, Palczewska G, Palczewski K, Wojtkowski M. PMID: 37058404; PMCID: PMC10140148.
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Eye on genome editing. J Exp Med. 2023 05 01; 220(5). Du SW, Palczewski K. PMID: 36930175; PMCID: PMC10035435.
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Investigating the Role of Rhodopsin F45L Mutation in Mouse Rod Photoreceptor Signaling and Survival. eNeuro. 2023 03; 10(3). Poria D, Kolesnikov AV, Lee TJ, Salom D, Palczewski K, Kefalov VJ. PMID: 36823167; PMCID: PMC9997694.
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Genome editing, a superior therapy for inherited retinal diseases. Vision Res. 2023 05; 206:108192. Yan AL, Du SW, Palczewski K. PMID: 36804635; PMCID: PMC10460145.
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From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation. Prog Retin Eye Res. 2023 03; 93:101170. Palczewska G, Wojtkowski M, Palczewski K. PMID: 36787681; PMCID: PMC10463242.
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Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2214276120. Dhankhar D, Salom D, Palczewski K, Rentzepis PM. PMID: 36577071; PMCID: PMC9910472.
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Chromophore hydrolysis and release from photoactivated rhodopsin in native membranes. Proc Natl Acad Sci U S A. 2022 Nov 08; 119(45):e2213911119. Hong JD, Salom D, Kochman MA, Kubas A, Kiser PD, Palczewski K. PMID: 36322748; PMCID: PMC9659404.
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Structural view of G protein-coupled receptor signaling in the retinal rod outer segment. Trends Biochem Sci. 2023 02; 48(2):172-186. Gulati S, Palczewski K. PMID: 36163145; PMCID: PMC9868064.
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Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration. Curr Biol. 2022 10 24; 32(20):4538-4546.e5. Huh CYL, Leinonen H, Nakayama T, Tomasello JR, Zhang J, Zeitoun J, Peach JP, Halabi M, Kiser JZ, Palczewski K, Kiser PD, Gandhi SP. PMID: 36152631; PMCID: PMC10083103.
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Precision genome editing in the eye. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2210104119. Suh S, Choi EH, Raguram A, Liu DR, Palczewski K. PMID: 36122230; PMCID: PMC9522375.
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Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles. Mol Ther Nucleic Acids. 2022 Sep 13; 29:823-835. Sun D, Sun W, Gao SQ, Lehrer J, Naderi A, Wei C, Lee S, Schilb AL, Scheidt J, Hall RC, Traboulsi EI, Palczewski K, Lu ZR. PMID: 36159595; PMCID: PMC9463552.
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Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice. Invest Ophthalmol Vis Sci. 2022 07 08; 63(8):18. Kolesnikov AV, Luu J, Jin H, Palczewski K, Kefalov VJ. PMID: 35861670; PMCID: PMC9315073.
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Visual System Hyperexcitability and Compromised V1 Receptive Field Properties in Early-Stage Retinitis Pigmentosa in Mice. eNeuro. 2022 May-Jun; 9(3). Leinonen H, Lyon DC, Palczewski K, Foik AT. PMID: 35701168; PMCID: PMC9239850.
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A large animal model of RDH5-associated retinopathy recapitulates important features of the human phenotype. Hum Mol Genet. 2022 04 22; 31(8):1263-1277. Occelli LM, Daruwalla A, De Silva SR, Winkler PA, Sun K, Pasmanter N, Minella A, Querubin J, Lyons LA, 99 Lives Consortium, Robson AG, Heon E, Michaelides M, Webster AR, Palczewski K, Vincent A, Mahroo OA, Kiser PD, Petersen-Jones SM. PMID: 34726233; PMCID: PMC9029234.
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Regenerating Skeletal Muscle Compensates for the Impaired Macrophage Functions Leading to Normal Muscle Repair in Retinol Saturase Null Mice. Cells. 2022 04 13; 11(8). Tarban N, Halász H, Gogolák P, Garabuczi É, Moise AR, Palczewski K, Sarang Z, Szondy Z. PMID: 35456012; PMCID: PMC9028072.
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Capturing a rhodopsin receptor signalling cascade across a native membrane. Nature. 2022 04; 604(7905):384-390. Chen S, Getter T, Salom D, Wu D, Quetschlich D, Chorev DS, Palczewski K, Robinson CV. PMID: 35388214; PMCID: PMC9007743.
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In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nat Commun. 2022 04 05; 13(1):1830. Choi EH, Suh S, Foik AT, Leinonen H, Newby GA, Gao XD, Banskota S, Hoang T, Du SW, Dong Z, Raguram A, Kohli S, Blackshaw S, Lyon DC, Liu DR, Palczewski K. PMID: 35383196; PMCID: PMC8983734.
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Inhibition of ceramide accumulation in AdipoR1-/- mice increases photoreceptor survival and improves vision. JCI Insight. 2022 02 22; 7(4). Lewandowski D, Foik AT, Smidak R, Choi EH, Zhang J, Hoang T, Tworak A, Suh S, Leinonen H, Dong Z, Pinto AF, Tom E, Luu J, Lee J, Ma X, Bieberich E, Blackshaw S, Saghatelian A, Lyon DC, Skowronska-Krawczyk D, Tabaka M, Palczewski K. PMID: 35015730; PMCID: PMC8876453.
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In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope. J Clin Invest. 2022 01 18; 132(2). Boguslawski J, Palczewska G, Tomczewski S, Milkiewicz J, Kasprzycki P, Stachowiak D, Komar K, Marzejon MJ, Sikorski BL, Hudzikowski A, Gluszek A, Laszczych Z, Karnowski K, Sobon G, Palczewski K, Wojtkowski M. PMID: 34847075; PMCID: PMC8759795.
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Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins. Cell. 2022 01 20; 185(2):250-265.e16. Banskota S, Raguram A, Suh S, Du SW, Davis JR, Choi EH, Wang X, Nielsen SC, Newby GA, Randolph PB, Osborn MJ, Musunuru K, Palczewski K, Liu DR. PMID: 35021064; PMCID: PMC8809250.
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VCP/p97 inhibitor CB-5083 modulates muscle pathology in a mouse model of VCP inclusion body myopathy. J Transl Med. 2022 01 08; 20(1):21. Cheng C, Weiss L, Leinonen H, Shmara A, Yin HZ, Ton T, Do A, Lee J, Ta L, Mohanty E, Vargas J, Weiss J, Palczewski K, Kimonis V. PMID: 34998409; PMCID: PMC8742393.
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Determinants shaping the nanoscale architecture of the mouse rod outer segment. Elife. 2021 12 21; 10. Pöge M, Mahamid J, Imanishi SS, Plitzko JM, Palczewski K, Baumeister W. PMID: 34931611; PMCID: PMC8758146.
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Identification of small-molecule allosteric modulators that act as enhancers/disrupters of rhodopsin oligomerization. J Biol Chem. 2021 12; 297(6):101401. Getter T, Kemp A, Vinberg F, Palczewski K. PMID: 34774799; PMCID: PMC8665362.
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MicroRNA regulation of critical retinal pigment epithelial functions. Trends Neurosci. 2022 01; 45(1):78-90. Du SW, Palczewski K. PMID: 34753606; PMCID: PMC9066699.
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Structural evidence for visual arrestin priming via complexation of phosphoinositols. Structure. 2022 02 03; 30(2):263-277.e5. Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD. PMID: 34678158; PMCID: PMC8818024.
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Theoretical Study of the Photoisomerization Mechanism of All-Trans-Retinyl Acetate. J Phys Chem A. 2021 Sep 30; 125(38):8358-8372. Kochman MA, Palczewski K, Kubas A. PMID: 34546761; PMCID: PMC8488936.
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Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies. Mol Pharmacol. 2021 11; 100(5):470-479. Kern TS, Du Y, Tang J, Lee CA, Liu H, Dreffs A, Leinonen H, Antonetti DA, Palczewski K. PMID: 34393108; PMCID: PMC9175131.
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Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition. J Cell Biol. 2021 08 02; 220(8). Sander CL, Sears AE, Pinto AFM, Choi EH, Kahremany S, Gao F, Salom D, Jin H, Pardon E, Suh S, Dong Z, Steyaert J, Saghatelian A, Skowronska-Krawczyk D, Kiser PD, Palczewski K. PMID: 34132745; PMCID: PMC8240855.
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Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy. J Med Chem. 2021 06 24; 64(12):8287-8302. Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. PMID: 34081480; PMCID: PMC8381290.
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THE LOSS OF INFRARED LIGHT SENSITIVITY OF PHOTORECEPTOR CELLS MEASURED WITH TWO-PHOTON EXCITATION AS AN INDICATOR OF DIABETIC RETINOPATHY: A Pilot Study. Retina. 2021 Jun 01; 41(6):1302-1308. Labuz G, Rayamajhi A, Khoramnia R, Palczewska G, Palczewski K, Holschbach A, Auffarth GU. PMID: 33323904; PMCID: PMC8137510.
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An inducible Cre mouse for studying roles of the RPE in retinal physiology and disease. JCI Insight. 2021 05 10; 6(9). Choi EH, Suh S, Einstein DE, Leinonen H, Dong Z, Rao SR, Fliesler SJ, Blackshaw S, Yu M, Peachey NS, Palczewski K, Kiser PD. PMID: 33784255; PMCID: PMC8262343.
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New focus on regulation of the rod photoreceptor phosphodiesterase. Curr Opin Struct Biol. 2021 08; 69:99-107. Gulati S, Palczewski K. PMID: 33945959; PMCID: PMC8405451.
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A p97/Valosin-Containing Protein Inhibitor Drug CB-5083 Has a Potent but Reversible Off-Target Effect on Phosphodiesterase-6. J Pharmacol Exp Ther. 2021 07; 378(1):31-41. Leinonen H, Cheng C, Pitkänen M, Sander CL, Zhang J, Saeid S, Turunen T, Shmara A, Weiss L, Ta L, Ton T, Koskelainen A, Vargas JD, Kimonis V, Palczewski K. PMID: 33931547; PMCID: PMC8456514.
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Peptide Derivatives of Retinylamine Prevent Retinal Degeneration with Minimal Side Effects on Vision in Mice. Bioconjug Chem. 2021 03 17; 32(3):572-583. Yu G, Gao SQ, Dong Z, Sheng L, Sun D, Zhang N, Zhang J, Margeivicus S, Fu P, Golczak M, Maeda A, Palczewski K, Lu ZR. PMID: 33677964; PMCID: PMC8087159.
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Retinoids in the visual cycle: role of the retinal G protein-coupled receptor. J Lipid Res. 2021; 62:100040. Choi EH, Daruwalla A, Suh S, Leinonen H, Palczewski K. PMID: 32493732; PMCID: PMC7910522.
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Function of mammalian M-cones depends on the level of CRALBP in Müller cells. J Gen Physiol. 2021 01 04; 153(1). Kolesnikov AV, Kiser PD, Palczewski K, Kefalov VJ. PMID: 33216847; PMCID: PMC7685772.
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Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model. J Control Release. 2021 02 10; 330:329-340. Sun D, Sun W, Gao SQ, Wei C, Naderi A, Schilb AL, Scheidt J, Lee S, Kern TS, Palczewski K, Lu ZR. PMID: 33358976; PMCID: PMC9066847.
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Two-photon microperimetry with picosecond pulses. Biomed Opt Express. 2021 Jan 01; 12(1):462-479. Marzejon MJ, Kornaszewski L, Boguslawski J, Ciacka P, Martynow M, Palczewska G, Mackowski S, Palczewski K, Wojtkowski M, Komar K. PMID: 33659083; PMCID: PMC7899501.
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Pathways and disease-causing alterations in visual chromophore production for vertebrate vision. J Biol Chem. 2021 Jan-Jun; 296:100072. Kiser PD, Palczewski K. PMID: 33187985; PMCID: PMC7948990.
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PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153. Blood. 2020 11 05; 136(19):2217-2228. Han X, Hofmann L, de la Fuente M, Alexander N, Palczewski K, INVENT Consortium, Nieman MT. PMID: 32575122; PMCID: PMC7645988.
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Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nat Biomed Eng. 2021 02; 5(2):169-178. Suh S, Choi EH, Leinonen H, Foik AT, Newby GA, Yeh WH, Dong Z, Kiser PD, Lyon DC, Liu DR, Palczewski K. PMID: 33077938; PMCID: PMC7885272.
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Homeostatic plasticity in the retina is associated with maintenance of night vision during retinal degenerative disease. Elife. 2020 09 22; 9. Leinonen H, Pham NC, Boyd T, Santoso J, Palczewski K, Vinberg F. PMID: 32960171; PMCID: PMC7529457.
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Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Hum Mol Genet. 2020 08 29; 29(15):2611-2624. Luu J, Kallestad L, Hoang T, Lewandowski D, Dong Z, Blackshaw S, Palczewski K. PMID: 32691052; PMCID: PMC7471509.
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Single particle cryo-EM of the complex between interphotoreceptor retinoid-binding protein and a monoclonal antibody. FASEB J. 2020 10; 34(10):13918-13934. Sears AE, Albiez S, Gulati S, Wang B, Kiser P, Kovacik L, Engel A, Stahlberg H, Palczewski K. PMID: 32860273; PMCID: PMC7589273.
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Noninvasive two-photon optical biopsy of retinal fluorophores. Proc Natl Acad Sci U S A. 2020 09 08; 117(36):22532-22543. Palczewska G, Boguslawski J, Stremplewski P, Kornaszewski L, Zhang J, Dong Z, Liang XX, Gratton E, Vogel A, Wojtkowski M, Palczewski K. PMID: 32848058; PMCID: PMC7486747.
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Shedding new light on the generation of the visual chromophore. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19629-19638. Palczewski K, Kiser PD. PMID: 32759209; PMCID: PMC7443880.
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Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases. Bioorg Med Chem Lett. 2020 09 15; 30(18):127421. Blum E, Zhang J, Korshin E, Palczewski K, Gruzman A. PMID: 32717613; PMCID: PMC7494577.
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Clinical Application of Infrared-Light Microperimetry in the Assessment of Scotopic-Eye Sensitivity. Transl Vis Sci Technol. 2020 07; 9(8):7. Labuz G, Rayamajhi A, Usinger J, Komar K, Merz P, Khoramnia R, Palczewska G, Palczewski K, Auffarth GU. PMID: 32855854; PMCID: PMC7422764.
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PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9922-9931. Corral-Serrano JC, Lamers IJC, van Reeuwijk J, Duijkers L, Hoogendoorn ADM, Yildirim A, Argyrou N, Ruigrok RAA, Letteboer SJF, Butcher R, van Essen MD, Sakami S, van Beersum SEC, Palczewski K, Cheetham ME, Liu Q, Boldt K, Wolfrum U, Ueffing M, Garanto A, Roepman R, Collin RWJ. PMID: 32312818; PMCID: PMC7211956.
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Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium. ACS Appl Bio Mater. 2020 May 18; 3(5):3078-3086. Sun D, Schur RM, Sears AE, Gao SQ, Sun W, Naderi A, Kern T, Palczewski K, Lu ZR. PMID: 34327311; PMCID: PMC8317636.
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Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation. PLoS One. 2020; 15(4):e0228121. Valdez-Lopez JC, Gulati S, Ortiz EA, Palczewski K, Robinson PR. PMID: 32236094; PMCID: PMC7112210.
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Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity. Biomolecules. 2019 11 13; 9(11). Sarang Z, Sághy T, Budai Z, Ujlaky-Nagy L, Bedekovics J, Beke L, Méhes G, Nagy G, Rühl R, Moise AR, Palczewski K, Szondy Z. PMID: 31766264; PMCID: PMC6920856.
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Photic generation of 11-cis-retinal in bovine retinal pigment epithelium. J Biol Chem. 2019 12 13; 294(50):19137-19154. Zhang J, Choi EH, Tworak A, Salom D, Leinonen H, Sander CL, Hoang TV, Handa JT, Blackshaw S, Palczewska G, Kiser PD, Palczewski K. PMID: 31694912; PMCID: PMC6916499.
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Tissue- and Species-Specific Patterns of RNA metabolism in Post-Mortem Mammalian Retina and Retinal Pigment Epithelium. Sci Rep. 2019 10 15; 9(1):14821. Kallestad L, Blackshaw S, Khalil AM, Palczewski K. PMID: 31616038; PMCID: PMC6794289.
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Non-viral Gene Therapy for Stargardt Disease with ECO/pRHO-ABCA4 Self-Assembled Nanoparticles. Mol Ther. 2020 01 08; 28(1):293-303. Sun D, Schur RM, Sears AE, Gao SQ, Vaidya A, Sun W, Maeda A, Kern T, Palczewski K, Lu ZR. PMID: 31611143; PMCID: PMC6952167.
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Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis. Org Biomol Chem. 2019 09 21; 17(35):8125-8139. Kahremany S, Sander CL, Tochtrop GP, Kubas A, Palczewski K. PMID: 31455964; PMCID: PMC6739180.
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Two-photon microperimetry: sensitivity of human photoreceptors to infrared light. Biomed Opt Express. 2019 Sep 01; 10(9):4551-4567. Ruminski D, Palczewska G, Nowakowski M, Zielinska A, Kefalov VJ, Komar K, Palczewski K, Wojtkowski M. PMID: 31565509; PMCID: PMC6757456.
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Cryo-EM structure of the native rhodopsin dimer in nanodiscs. J Biol Chem. 2019 09 27; 294(39):14215-14230. Zhao DY, Pöge M, Morizumi T, Gulati S, Van Eps N, Zhang J, Miszta P, Filipek S, Mahamid J, Plitzko JM, Baumeister W, Ernst OP, Palczewski K. PMID: 31399513; PMCID: PMC6768649.
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Sensitivity of Mammalian Cone Photoreceptors to Infrared Light. Neuroscience. 2019 09 15; 416:100-108. Vinberg F, Palczewska G, Zhang J, Komar K, Wojtkowski M, Kefalov VJ, Palczewski K. PMID: 31400484; PMCID: PMC6815255.
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Catalytic synthesis of 9-cis-retinoids: mechanistic insights. Dalton Trans. 2019 Jul 16; 48(28):10581-10595. Kahremany S, Kubas A, Tochtrop GP, Palczewski K. PMID: 31218312; PMCID: PMC7004310.
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Stereospecific modulation of dimeric rhodopsin. FASEB J. 2019 08; 33(8):9526-9539. Getter T, Gulati S, Zimmerman R, Chen Y, Vinberg F, Palczewski K. PMID: 31121099; PMCID: PMC6662988.
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Retinal Gene Distribution and Functionality Implicated in Inherited Retinal Degenerations Can Reveal Disease-Relevant Pathways for Pharmacologic Intervention. Pharmaceuticals (Basel). 2019 May 17; 12(2). Mustafi D, Arbabi A, Ameri H, Palczewski K. PMID: 31108889; PMCID: PMC6631933.
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The selective estrogen receptor modulator raloxifene mitigates the effect of all-trans-retinal toxicity in photoreceptor degeneration. J Biol Chem. 2019 06 14; 294(24):9461-9475. Getter T, Suh S, Hoang T, Handa JT, Dong Z, Ma X, Chen Y, Blackshaw S, Palczewski K. PMID: 31073029; PMCID: PMC6579480.
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Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates. J Biol Chem. 2019 05 17; 294(20):8123-8133. Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K. PMID: 30948514; PMCID: PMC6527158.
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Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1538-1546. Liu H, Tang J, Du Y, Saadane A, Samuels I, Veenstra A, Kiser JZ, Palczewski K, Kern TS. PMID: 30994864; PMCID: PMC6736377.
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A Mixture of U.S. Food and Drug Administration-Approved Monoaminergic Drugs Protects the Retina From Light Damage in Diverse Models of Night Blindness. Invest Ophthalmol Vis Sci. 2019 04 01; 60(5):1442-1453. Leinonen H, Choi EH, Gardella A, Kefalov VJ, Palczewski K. PMID: 30947334; PMCID: PMC6736410.
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Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases. Sci Adv. 2019 02; 5(2):eaav4322. Gulati S, Palczewski K, Engel A, Stahlberg H, Kovacik L. PMID: 30820458; PMCID: PMC6392808.
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Specificity of the chromophore-binding site in human cone opsins. J Biol Chem. 2019 04 12; 294(15):6082-6093. Katayama K, Gulati S, Ortega JT, Alexander NS, Sun W, Shenouda MM, Palczewski K, Jastrzebska B. PMID: 30770468; PMCID: PMC6463688.
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Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB J. 2019 04; 33(4):5782-5792. Kiser PD, Kolesnikov AV, Kiser JZ, Dong Z, Chaurasia B, Wang L, Summers SA, Hoang T, Blackshaw S, Peachey NS, Kefalov VJ, Palczewski K. PMID: 30645148; PMCID: PMC6436658.
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Immuno-TEM/STEM in Retinal Research. Methods Mol Biol. 2019; 1834:311-332. Sakami S, Palczewski K. PMID: 30324452; PMCID: PMC6991117.
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Noninvasive Two-Photon Microscopy Imaging of Mouse Retina and Retinal Pigment Epithelium. Methods Mol Biol. 2019; 1834:333-343. Palczewska G, Kern TS, Palczewski K. PMID: 30324453; PMCID: PMC6991118.
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Müller glia phagocytose dead photoreceptor cells in a mouse model of retinal degenerative disease. FASEB J. 2019 03; 33(3):3680-3692. Sakami S, Imanishi Y, Palczewski K. PMID: 30462532; PMCID: PMC6404573.
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Apo-Opsin Exists in Equilibrium Between a Predominant Inactive and a Rare Highly Active State. J Neurosci. 2019 01 09; 39(2):212-223. Sato S, Jastrzebska B, Engel A, Palczewski K, Kefalov VJ. PMID: 30459230; PMCID: PMC6325258.
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Structural biology of 11-cis-retinaldehyde production in the classical visual cycle. Biochem J. 2018 10 22; 475(20):3171-3188. Daruwalla A, Choi EH, Palczewski K, Kiser PD. PMID: 30352831; PMCID: PMC6440480.
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Two-photon imaging of the mammalian retina with ultrafast pulsing laser. JCI Insight. 2018 09 06; 3(17). Palczewska G, Stremplewski P, Suh S, Alexander N, Salom D, Dong Z, Ruminski D, Choi EH, Sears AE, Kern TS, Wojtkowski M, Palczewski K. PMID: 30185665; PMCID: PMC6171813.
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Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol. 2018 10; 94(4):1132-1144. Gao S, Parmar T, Palczewska G, Dong Z, Golczak M, Palczewski K, Jastrzebska B. PMID: 30018116; PMCID: PMC6108575.
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Exploring a new ligand binding site of G protein-coupled receptors. Chem Sci. 2018 Aug 21; 9(31):6480-6489. Chan HCS, Wang J, Palczewski K, Filipek S, Vogel H, Liu ZJ, Yuan S. PMID: 30310578; PMCID: PMC6115637.
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Insights into the pathogenesis of dominant retinitis pigmentosa associated with a D477G mutation in RPE65. Hum Mol Genet. 2018 07 01; 27(13):2225-2243. Choi EH, Suh S, Sander CL, Hernandez CJO, Bulman ER, Khadka N, Dong Z, Shi W, Palczewski K, Kiser PD. PMID: 29659842; PMCID: PMC6005012.
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Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun. 2018 05 18; 9(1):1996. Gulati S, Jin H, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewski K. PMID: 29777099; PMCID: PMC5959942.
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A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 05 17; 9(1):1976. Chen Y, Chen Y, Jastrzebska B, Golczak M, Gulati S, Tang H, Seibel W, Li X, Jin H, Han Y, Gao S, Zhang J, Liu X, Heidari-Torkabadi H, Stewart PL, Harte WE, Tochtrop GP, Palczewski K. PMID: 29773803; PMCID: PMC5958115.
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A Small Chaperone Improves Folding and Routing of Rhodopsin Mutants Linked to Inherited Blindness. iScience. 2018 Jun 29; 4:1-19. Behnen P, Felline A, Comitato A, Di Salvo MT, Raimondi F, Gulati S, Kahremany S, Palczewski K, Marigo V, Fanelli F. PMID: 30240733; PMCID: PMC6147235.
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Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function. J Gen Physiol. 2018 04 02; 150(4):571-590. Kiser PD, Zhang J, Sharma A, Angueyra JM, Kolesnikov AV, Badiee M, Tochtrop GP, Kinoshita J, Peachey NS, Li W, Kefalov VJ, Palczewski K. PMID: 29500274; PMCID: PMC5881442.
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Human aging and disease: Lessons from age-related macular degeneration. Proc Natl Acad Sci U S A. 2018 03 20; 115(12):2866-2872. Luu J, Palczewski K. PMID: 29483257; PMCID: PMC5866596.
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Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs. Mol Pharmacol. 2018 05; 93(5):438-452. Gao S, Kahremany S, Zhang J, Jastrzebska B, Querubin J, Petersen-Jones SM, Palczewski K. PMID: 29453250; PMCID: PMC5878677.
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Increasing the Stability of Recombinant Human Green Cone Pigment. Biochemistry. 2018 02 13; 57(6):1022-1030. Owen TS, Salom D, Sun W, Palczewski K. PMID: 29320632; PMCID: PMC5853123.
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New GABA modulators protect photoreceptor cells from light-induced degeneration in mouse models. FASEB J. 2018 06; 32(6):3289-3300. Schur RM, Gao S, Yu G, Chen Y, Maeda A, Palczewski K, Lu ZR. PMID: 29401616; PMCID: PMC5956245.
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An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018; 14(7):688-694. Trifonov L, Afri M, Palczewski K, Korshin EE, Gruzman A. PMID: 29651942; PMCID: PMC6993063.
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A Combination of G Protein-Coupled Receptor Modulators Protects Photoreceptors from Degeneration. J Pharmacol Exp Ther. 2018 02; 364(2):207-220. Orban T, Leinonen H, Getter T, Dong Z, Sun W, Gao S, Veenstra A, Heidari-Torkabadi H, Kern TS, Kiser PD, Palczewski K. PMID: 29162627; PMCID: PMC5771314.
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Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 11 07; 7(1):14623. Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. PMID: 29116131; PMCID: PMC5676788.
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Multimodal nonlinear optical imaging of unstained retinas in the epi-direction with a sub-40 fs Yb-fiber laser. Biomed Opt Express. 2017 Nov 01; 8(11):5228-5242. Murashova GA, Mancuso CA, Canfield JL, Sakami S, Palczewski K, Palczewska G, Dantus M. PMID: 29188116; PMCID: PMC5695966.
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Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9675-E9684. Kolesnikov AV, Orban T, Jin H, Brooks C, Hofmann L, Dong Z, Sokolov M, Palczewski K, Kefalov VJ. PMID: 29078372; PMCID: PMC5692576.
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Quantitative phosphoproteomics reveals involvement of multiple signaling pathways in early phagocytosis by the retinal pigmented epithelium. J Biol Chem. 2017 12 01; 292(48):19826-19839. Chiang CK, Tworak A, Kevany BM, Xu B, Mayne J, Ning Z, Figeys D, Palczewski K. PMID: 28978645; PMCID: PMC5712622.
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Designing Safer Analgesics via μ-Opioid Receptor Pathways. Trends Pharmacol Sci. 2017 11; 38(11):1016-1037. Chan HCS, McCarthy D, Li J, Palczewski K, Yuan S. PMID: 28935293; PMCID: PMC5690544.
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Towards Treatment of Stargardt Disease: Workshop Organized and Sponsored by the Foundation Fighting Blindness. Transl Vis Sci Technol. 2017 09; 6(5):6. Sears AE, Bernstein PS, Cideciyan AV, Hoyng C, Charbel Issa P, Palczewski K, Rosenfeld PJ, Sadda S, Schraermeyer U, Sparrow JR, Washington I, Scholl HPN. PMID: 28920007; PMCID: PMC5599228.
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Crowd sourcing difficult problems in protein science. Protein Sci. 2017 Nov; 26(11):2118-2125. Alexander NS, Palczewski K. PMID: 28762619; PMCID: PMC5654861.
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Photoreceptor cells produce inflammatory products that contribute to retinal vascular permeability in a mouse model of diabetes. Diabetologia. 2017 10; 60(10):2111-2120. Tonade D, Liu H, Palczewski K, Kern TS. PMID: 28755268; PMCID: PMC5660634.
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The role of retinol dehydrogenase 10 in the cone visual cycle. Sci Rep. 2017 05 24; 7(1):2390. Xue Y, Sato S, Razafsky D, Sahu B, Shen SQ, Potter C, Sandell LL, Corbo JC, Palczewski K, Maeda A, Hodzic D, Kefalov VJ. PMID: 28539612; PMCID: PMC5443843.
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Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center. Biochemistry. 2017 06 06; 56(22):2836-2852. Sui X, Weitz AC, Farquhar ER, Badiee M, Banerjee S, von Lintig J, Tochtrop GP, Palczewski K, Hendrich MP, Kiser PD. PMID: 28493664; PMCID: PMC5541372.
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Complex binding pathways determine the regeneration of mammalian green cone opsin with a locked retinal analogue. J Biol Chem. 2017 06 30; 292(26):10983-10997. Alexander NS, Katayama K, Sun W, Salom D, Gulati S, Zhang J, Mogi M, Palczewski K, Jastrzebska B. PMID: 28487362; PMCID: PMC5491782.
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Rational Tuning of Visual Cycle Modulator Pharmacodynamics. J Pharmacol Exp Ther. 2017 07; 362(1):131-145. Kiser PD, Zhang J, Badiee M, Kinoshita J, Peachey NS, Tochtrop GP, Palczewski K. PMID: 28476927; PMCID: PMC5490204.
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Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. Biochemistry. 2017 05 02; 56(17):2338-2348. Hofmann L, Alexander NS, Sun W, Zhang J, Orban T, Palczewski K. PMID: 28402104; PMCID: PMC5501310.
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Skunkworks project for Big Pharma. Pharmacol Res. 2017 Oct; 124:167-168. Palczewski K. PMID: 28363722; PMCID: PMC5596451.
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Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism. Proc Natl Acad Sci U S A. 2017 03 28; 114(13):E2608-E2615. Gulati S, Jastrzebska B, Banerjee S, Placeres ÁL, Miszta P, Gao S, Gunderson K, Tochtrop GP, Filipek S, Katayama K, Kiser PD, Mogi M, Stewart PL, Palczewski K. PMID: 28289214; PMCID: PMC5380078.
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Epi-direction detected multimodal imaging of an unstained mouse retina with a Yb-fiber laser. Proc SPIE Int Soc Opt Eng. 2017 Mar; 10069. Murashova GA, Mancuso CA, Sakami S, Palczewski K, Palczewska G, Dantus M. PMID: 28989217; PMCID: PMC5627661.
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Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017 Jun 16; 7:42-52. Sun D, Sahu B, Gao S, Schur RM, Vaidya AM, Maeda A, Palczewski K, Lu ZR. PMID: 28624218; PMCID: PMC5363681.
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MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice. J Biol Chem. 2017 02 24; 292(8):3366-3378. Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K. PMID: 28104803; PMCID: PMC5336169.
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Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Hum Mol Genet. 2017 01 15; 26(2):305-319. Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, Palczewski K, Sherman MY, Reeves PJ, Cheetham ME. PMID: 28065882; PMCID: PMC5351934.
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Formation and Clearance of All-Trans-Retinol in Rods Investigated in the Living Primate Eye With Two-Photon Ophthalmoscopy. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):604-613. Sharma R, Schwarz C, Hunter JJ, Palczewska G, Palczewski K, Williams DR. PMID: 28129424; PMCID: PMC5283085.
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A G Protein-Coupled Receptor Dimerization Interface in Human Cone Opsins. Biochemistry. 2017 Jan 10; 56(1):61-72. Jastrzebska B, Comar WD, Kaliszewski MJ, Skinner KC, Torcasio MH, Esway AS, Jin H, Palczewski K, Smith AW. PMID: 28045251; PMCID: PMC5274527.
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Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Biochemistry. 2016 Nov 29; 55(47):6545-6557. Hofmann L, Tsybovsky Y, Alexander NS, Babino D, Leung NY, Montell C, Banerjee S, von Lintig J, Palczewski K. PMID: 27809489; PMCID: PMC5154250.
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Safety assessment in macaques of light exposures for functional two-photon ophthalmoscopy in humans. Biomed Opt Express. 2016 Dec 01; 7(12):5148-5169. Schwarz C, Sharma R, Fischer WS, Chung M, Palczewska G, Palczewski K, Williams DR, Hunter JJ. PMID: 28018732; PMCID: PMC5175559.
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Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium. J Biol Chem. 2016 Dec 23; 291(52):26937-26949. Palczewska G, Maeda A, Golczak M, Arai E, Dong Z, Perusek L, Kevany B, Palczewski K. PMID: 27875314; PMCID: PMC5207201.
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Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa. Pharmacol Res. 2017 01; 115:1-13. Chen Y, Brooks MJ, Gieser L, Swaroop A, Palczewski K. PMID: 27838510; PMCID: PMC5205556.
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Transcriptome analysis reveals rod/cone photoreceptor specific signatures across mammalian retinas. Hum Mol Genet. 2016 10 15; 25(20):4376-4388. Mustafi D, Kevany BM, Bai X, Golczak M, Adams MD, Wynshaw-Boris A, Palczewski K. PMID: 28172828; PMCID: PMC6078599.
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Eyes on systems pharmacology. Pharmacol Res. 2016 Dec; 114:39-41. Chen Y, Kern TS, Kiser PD, Palczewski K. PMID: 27720767; PMCID: PMC5154905.
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Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucleic Acids Res. 2016 Dec 01; 44(21):10467-10479. Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ. PMID: 27655633; PMCID: PMC5137443.
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Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes. Invest Ophthalmol Vis Sci. 2016 08 01; 57(10):4272-81. Liu H, Tang J, Du Y, Saadane A, Tonade D, Samuels I, Veenstra A, Palczewski K, Kern TS. PMID: 27548901; PMCID: PMC5015983.
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The Molecular Mechanism of P2Y1 Receptor Activation. Angew Chem Int Ed Engl. 2016 08 22; 55(35):10331-5. Yuan S, Chan HC, Vogel H, Filipek S, Stevens RC, Palczewski K. PMID: 27460867; PMCID: PMC4996126.
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Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci Signal. 2016 07 26; 9(438):ra74. Chen Y, Palczewska G, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K. PMID: 27460988; PMCID: PMC4972460.
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Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase. J Biol Chem. 2016 09 09; 291(37):19401-12. Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 27453555; PMCID: PMC5016679.
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Retinoids and Retinal Diseases. Annu Rev Vis Sci. 2016 10; 2:197-234. Kiser PD, Palczewski K. PMID: 27917399; PMCID: PMC5132409.
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Image registration and averaging of low laser power two-photon fluorescence images of mouse retina. Biomed Opt Express. 2016 Jul 01; 7(7):2671-91. Alexander NS, Palczewska G, Stremplewski P, Wojtkowski M, Kern TS, Palczewski K. PMID: 27446697; PMCID: PMC4948621.
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Mechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor. Angew Chem Int Ed Engl. 2016 07 18; 55(30):8661-5. Yuan S, Peng Q, Palczewski K, Vogel H, Filipek S. PMID: 27244650; PMCID: PMC4957245.
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Lecithin:Retinol Acyltransferase: A Key Enzyme Involved in the Retinoid (visual) Cycle. Biochemistry. 2016 Jun 07; 55(22):3082-91. Sears AE, Palczewski K. PMID: 27183166; PMCID: PMC5555363.
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Dominant and recessive mutations in rhodopsin activate different cell death pathways. Hum Mol Genet. 2016 07 01; 25(13):2801-2812. Comitato A, Di Salvo MT, Turchiano G, Montanari M, Sakami S, Palczewski K, Marigo V. PMID: 27149983.
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A small molecule mitigates hearing loss in a mouse model of Usher syndrome III. Nat Chem Biol. 2016 06; 12(6):444-51. Alagramam KN, Gopal SR, Geng R, Chen DH, Nemet I, Lee R, Tian G, Miyagi M, Malagu KF, Lock CJ, Esmieu WR, Owens AP, Lindsay NA, Ouwehand K, Albertus F, Fischer DF, Bürli RW, MacLeod AM, Harte WE, Palczewski K, Imanishi Y. PMID: 27110679; PMCID: PMC4871731.
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Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage. J Biol Chem. 2016 Jun 17; 291(25):12951-9. Han X, Tang J, Wang J, Ren F, Zheng J, Gragg M, Kiser P, Park PS, Palczewski K, Yao X, Zhang Y. PMID: 27129240; PMCID: PMC4933214.
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An effective thiol-reactive probe for differential scanning fluorimetry with a standard real-time polymerase chain reaction device. Anal Biochem. 2016 Apr 15; 499:63-65. Hofmann L, Gulati S, Sears A, Stewart PL, Palczewski K. PMID: 26851339; PMCID: PMC4788517.
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The Biochemical Basis of Vitamin A3 Production in Arthropod Vision. ACS Chem Biol. 2016 Apr 15; 11(4):1049-57. Babino D, Golczak M, Kiser PD, Wyss A, Palczewski K, von Lintig J. PMID: 26811964; PMCID: PMC4841470.
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Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):632-46. Sharma R, Williams DR, Palczewska G, Palczewski K, Hunter JJ. PMID: 26903224; PMCID: PMC4771181.
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In Vivo Two-Photon Fluorescence Kinetics of Primate Rods and Cones. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):647-57. Sharma R, Schwarz C, Williams DR, Palczewska G, Palczewski K, Hunter JJ. PMID: 26903225; PMCID: PMC4771186.
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Utilization of Dioxygen by Carotenoid Cleavage Oxygenases. J Biol Chem. 2015 Dec 18; 290(51):30212-23. Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. PMID: 26499794; PMCID: PMC4683246.
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Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina. J Physiol. 2015 Nov 15; 593(22):4923-41. Kolesnikov AV, Maeda A, Tang PH, Imanishi Y, Palczewski K, Kefalov VJ. PMID: 26350353; PMCID: PMC4650407.
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Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. J Biol Chem. 2015 Nov 27; 290(48):29035-44. Perusek L, Sahu B, Parmar T, Maeno H, Arai E, Le YZ, Subauste CS, Chen Y, Palczewski K, Maeda A. PMID: 26468292; PMCID: PMC4661415.
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The impact of microRNA gene regulation on the survival and function of mature cell types in the eye. FASEB J. 2016 Jan; 30(1):23-33. Sundermeier TR, Palczewski K. PMID: 26399786; PMCID: PMC4684546.
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Conditional Ablation of Retinol Dehydrogenase 10 in the Retinal Pigmented Epithelium Causes Delayed Dark Adaption in Mice. J Biol Chem. 2015 Nov 06; 290(45):27239-27247. Sahu B, Sun W, Perusek L, Parmar V, Le YZ, Griswold MD, Palczewski K, Maeda A. PMID: 26391396; PMCID: PMC4646373.
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Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface. J Biol Chem. 2015 Oct 16; 290(42):25728-44. Jastrzebska B, Chen Y, Orban T, Jin H, Hofmann L, Palczewski K. PMID: 26330551; PMCID: PMC4646215.
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Periscope for noninvasive two-photon imaging of murine retina in vivo. Biomed Opt Express. 2015 Sep 01; 6(9):3352-61. Stremplewski P, Komar K, Palczewski K, Wojtkowski M, Palczewska G. PMID: 26417507; PMCID: PMC4574663.
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Self-Assembly of a Multifunctional Lipid With Core-Shell Dendrimer DNA Nanoparticles Enhanced Efficient Gene Delivery at Low Charge Ratios into RPE Cells. Macromol Biosci. 2015 Dec; 15(12):1663-72. Sun D, Maeno H, Gujrati M, Schur R, Maeda A, Maeda T, Palczewski K, Lu ZR. PMID: 26271011; PMCID: PMC4770799.
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Semi-automated discrimination of retinal pigmented epithelial cells in two-photon fluorescence images of mouse retinas. Biomed Opt Express. 2015 Aug 01; 6(8):3032-52. Alexander NS, Palczewska G, Palczewski K. PMID: 26309765; PMCID: PMC4541529.
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Serum levels of lipid metabolites in age-related macular degeneration. FASEB J. 2015 Nov; 29(11):4579-88. Orban T, Johnson WM, Dong Z, Maeda T, Maeda A, Sakai T, Tsuneoka H, Mieyal JJ, Palczewski K. PMID: 26187344; PMCID: PMC4608905.
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Advances in understanding the molecular basis of the first steps in color vision. Prog Retin Eye Res. 2015 Nov; 49:46-66. Hofmann L, Palczewski K. PMID: 26187035; PMCID: PMC4651776.
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Retinylamine Benefits Early Diabetic Retinopathy in Mice. J Biol Chem. 2015 Aug 28; 290(35):21568-79. Liu H, Tang J, Du Y, Lee CA, Golczak M, Muthusamy A, Antonetti DA, Veenstra AA, Amengual J, von Lintig J, Palczewski K, Kern TS. PMID: 26139608; PMCID: PMC4571881.
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Manganese-Enhanced MRI for Preclinical Evaluation of Retinal Degeneration Treatments. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4936-42. Schur RM, Sheng L, Sahu B, Yu G, Gao S, Yu X, Maeda A, Palczewski K, Lu ZR. PMID: 26225634; PMCID: PMC4525634.
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Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 2015 Jul 01; 125(7):2781-94. Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. PMID: 26075817; PMCID: PMC4563688.
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The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors. Angew Chem Int Ed Engl. 2015 Jun 22; 54(26):7560-3. Yuan S, Palczewski K, Peng Q, Kolinski M, Vogel H, Filipek S. PMID: 25968837.
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Improvement in vision: a new goal for treatment of hereditary retinal degenerations. Expert Opin Orphan Drugs. 2015 May 04; 3(5):563-575. Jacobson SG, Cideciyan AV, Aguirre GD, Roman AJ, Sumaroka A, Hauswirth WW, Palczewski K. PMID: 26246977; PMCID: PMC4487613.
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Catalytic mechanism of a retinoid isomerase essential for vertebrate vision. Nat Chem Biol. 2015 Jun; 11(6):409-15. Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. PMID: 25894083; PMCID: PMC4433804.
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A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2553-67. Chen Y, Tang H, Seibel W, Papoian R, Li X, Lambert NA, Palczewski K. PMID: 25783607; PMCID: PMC4554260.
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Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders. Annu Rev Pharmacol Toxicol. 2016; 56:273-98. Chen Y, Palczewski K. PMID: 25839098; PMCID: PMC4580525.
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Crystallization of proteins from crude bovine rod outer segments. Methods Enzymol. 2015; 557:439-58. Baker BY, Gulati S, Shi W, Wang B, Stewart PL, Palczewski K. PMID: 25950977; PMCID: PMC4486017.
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Protein misfolding and the pathogenesis of ABCA4-associated retinal degenerations. Hum Mol Genet. 2015 Jun 01; 24(11):3220-37. Zhang N, Tsybovsky Y, Kolesnikov AV, Rozanowska M, Swider M, Schwartz SB, Stone EM, Palczewska G, Maeda A, Kefalov VJ, Jacobson SG, Cideciyan AV, Palczewski K. PMID: 25712131; PMCID: PMC4424957.
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Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May; 29(5):2194-204. Du Y, Cramer M, Lee CA, Tang J, Muthusamy A, Antonetti DA, Jin H, Palczewski K, Kern TS. PMID: 25667222; PMCID: PMC4415023.
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Animals deficient in C2Orf71, an autosomal recessive retinitis pigmentosa-associated locus, develop severe early-onset retinal degeneration. Hum Mol Genet. 2015 May 01; 24(9):2627-40. Kevany BM, Zhang N, Jastrzebska B, Palczewski K. PMID: 25616964; PMCID: PMC4383867.
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Prolonged prevention of retinal degeneration with retinylamine loaded nanoparticles. Biomaterials. 2015 Mar; 44:103-10. Puntel A, Maeda A, Golczak M, Gao SQ, Yu G, Palczewski K, Lu ZR. PMID: 25617130; PMCID: PMC4393824.
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The G protein-coupled receptor rhodopsin: a historical perspective. Methods Mol Biol. 2015; 1271:3-18. Hofmann L, Palczewski K. PMID: 25697513; PMCID: PMC4593475.
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Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration. Mol Pharmacol. 2015; 87(3):477-91. Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. PMID: 25538117; PMCID: PMC4352584.
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Serial block face-scanning electron microscopy: a method to study retinal degenerative phenotypes. Curr Protoc Mouse Biol. 2014 Dec 11; 4(4):197-204. Mustafi D, Kikano S, Palczewski K. PMID: 25621191; PMCID: PMC4303034.
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Human infrared vision is triggered by two-photon chromophore isomerization. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5445-54. Palczewska G, Vinberg F, Stremplewski P, Bircher MP, Salom D, Komar K, Zhang J, Cascella M, Wojtkowski M, Kefalov VJ, Palczewski K. PMID: 25453064; PMCID: PMC4273384.
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Multifunctional PEG retinylamine conjugate provides prolonged protection against retinal degeneration in mice. Biomacromolecules. 2014 Dec 08; 15(12):4570-8. Yu G, Wu X, Ayat N, Maeda A, Gao SQ, Golczak M, Palczewski K, Lu ZR. PMID: 25390360; PMCID: PMC4261990.
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Isotopic labeling of mammalian G protein-coupled receptors heterologously expressed in Caenorhabditis elegans. Anal Biochem. 2015 Mar 01; 472:30-6. Salom D, Cao P, Yuan Y, Miyagi M, Feng Z, Palczewski K. PMID: 25461480; PMCID: PMC4322386.
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LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 2015 Jan; 11(1):26-32. Golczak M, Sears AE, Kiser PD, Palczewski K. PMID: 25383759; PMCID: PMC4270908.
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Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2014 Oct 22; 55(10):6651-72. Palczewski K. PMID: 25338686; PMCID: PMC4207101.
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Robust Endoplasmic Reticulum-Associated Degradation of Rhodopsin Precedes Retinal Degeneration. Mol Neurobiol. 2015 Aug; 52(1):679-95. Chiang WC, Kroeger H, Sakami S, Messah C, Yasumura D, Matthes MT, Coppinger JA, Palczewski K, LaVail MM, Lin JH. PMID: 25270370; PMCID: PMC4383737.
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High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci. 2014 Nov; 23(11):1629-39. Baker BY, Shi W, Wang B, Palczewski K. PMID: 25176140; PMCID: PMC4241113.
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Structural insights into activation of the retinal L-type Ca²⁺ channel (Cav1.4) by Ca²⁺-binding protein 4 (CaBP4). J Biol Chem. 2014 Nov 07; 289(45):31262-73. Park S, Li C, Haeseleer F, Palczewski K, Ames JB. PMID: 25258313; PMCID: PMC4223327.
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Argonaute high-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation reveals a snapshot of miRNA gene regulation in the mammalian retina. Biochemistry. 2014 Sep 23; 53(37):5831-3. Sundermeier TR, Jin H, Kleinjan ML, Mustafi D, Licatalosi DD, Palczewski K. PMID: 25204418; PMCID: PMC4172207.
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Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathway. Nat Commun. 2014 Sep 09; 5:4733. Yuan S, Filipek S, Palczewski K, Vogel H. PMID: 25203160.
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Endogenous fluorophores enable two-photon imaging of the primate eye. Invest Ophthalmol Vis Sci. 2014 Jun 26; 55(7):4438-47. Palczewska G, Golczak M, Williams DR, Hunter JJ, Palczewski K. PMID: 24970255; PMCID: PMC4106253.
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Noninvasive two-photon microscopy imaging of mouse retina and retinal pigment epithelium through the pupil of the eye. Nat Med. 2014 Jul; 20(7):785-9. Palczewska G, Dong Z, Golczak M, Hunter JJ, Williams DR, Alexander NS, Palczewski K. PMID: 24952647; PMCID: PMC4087080.
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Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase. Mol Pharmacol. 2014 Aug; 86(2):231-42. Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. PMID: 24913940; PMCID: PMC4127928.
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Time-resolved fluorescence spectroscopy measures clustering and mobility of a G protein-coupled receptor opsin in live cell membranes. J Am Chem Soc. 2014 Jun 11; 136(23):8342-9. Comar WD, Schubert SM, Jastrzebska B, Palczewski K, Smith AW. PMID: 24831851; PMCID: PMC4063175.
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STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014 Oct 15; 23(20):5402-17. Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, Von Lintig J. PMID: 24852372; PMCID: PMC4168826.
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DICER1 is essential for survival of postmitotic rod photoreceptor cells in mice. FASEB J. 2014 Aug; 28(8):3780-91. Sundermeier TR, Zhang N, Vinberg F, Mustafi D, Kohno H, Golczak M, Bai X, Maeda A, Kefalov VJ, Palczewski K. PMID: 24812086; PMCID: PMC4101655.
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Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice. Proc Natl Acad Sci U S A. 2014 Apr 08; 111(14):E1428-37. Maeda A, Palczewska G, Golczak M, Kohno H, Dong Z, Maeda T, Palczewski K. PMID: 24706832; PMCID: PMC3986171.
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Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO). J Biol Chem. 2014 May 02; 289(18):12286-99. Sui X, Kiser PD, Che T, Carey PR, Golczak M, Shi W, von Lintig J, Palczewski K. PMID: 24648526; PMCID: PMC4007427.
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R9AP overexpression alters phototransduction kinetics in iCre75 mice. Invest Ophthalmol Vis Sci. 2014 Mar 06; 55(3):1339-47. Sundermeier TR, Vinberg F, Mustafi D, Bai X, Kefalov VJ, Palczewski K. PMID: 24526444; PMCID: PMC3945901.
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Expression, purification and structural properties of ABC transporter ABCA4 and its individual domains. Protein Expr Purif. 2014 May; 97:50-60. Tsybovsky Y, Palczewski K. PMID: 24583180; PMCID: PMC4033903.
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Reliable determination of site-specific in vivo protein N-glycosylation based on collision-induced MS/MS and chromatographic retention time. J Am Soc Mass Spectrom. 2014 May; 25(5):729-41. Wang B, Tsybovsky Y, Palczewski K, Chance MR. PMID: 24549892; PMCID: PMC3988243.
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The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements. J Struct Biol. 2014 Apr; 186(1):86-94. Tu X, Palczewski K. PMID: 24531000; PMCID: PMC3993933.
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Inherent instability of the retinitis pigmentosa P23H mutant opsin. J Biol Chem. 2014 Mar 28; 289(13):9288-303. Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. PMID: 24515108; PMCID: PMC3979360.
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Synthesis and evaluation of a nanoglobular dendrimer 5-aminosalicylic Acid conjugate with a hydrolyzable schiff base spacer for treating retinal degeneration. ACS Nano. 2014 Jan 28; 8(1):153-61. Wu X, Yu G, Luo C, Maeda A, Zhang N, Sun D, Zhou Z, Puntel A, Palczewski K, Lu ZR. PMID: 24350906; PMCID: PMC4060971.
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Human cellular retinaldehyde-binding protein has secondary thermal 9-cis-retinal isomerase activity. J Am Chem Soc. 2014 Jan 08; 136(1):137-46. Bolze CS, Helbling RE, Owen RL, Pearson AR, Pompidor G, Dworkowski F, Fuchs MR, Furrer J, Golczak M, Palczewski K, Cascella M, Stocker A. PMID: 24328211; PMCID: PMC3936205.
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Structural approaches to understanding retinal proteins needed for vision. Curr Opin Cell Biol. 2014 Apr; 27:32-43. Orban T, Jastrzebska B, Palczewski K. PMID: 24680428; PMCID: PMC3971393.
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Systems pharmacology identifies drug targets for Stargardt disease-associated retinal degeneration. J Clin Invest. 2013 Dec; 123(12):5119-34. Chen Y, Palczewska G, Mustafi D, Golczak M, Dong Z, Sawada O, Maeda T, Maeda A, Palczewski K. PMID: 24231350; PMCID: PMC3859412.
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P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet. 2014 Apr 01; 23(7):1723-41. Sakami S, Kolesnikov AV, Kefalov VJ, Palczewski K. PMID: 24214395; PMCID: PMC3943518.
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Structural and functional analysis of the native peripherin-ROM1 complex isolated from photoreceptor cells. J Biol Chem. 2013 Dec 20; 288(51):36272-84. Kevany BM, Tsybovsky Y, Campuzano ID, Schnier PD, Engel A, Palczewski K. PMID: 24196967; PMCID: PMC3868743.
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Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo. J Biol Chem. 2013 Nov 29; 288(48):34484-93. Maeda T, Lee MJ, Palczewska G, Marsili S, Tesar PJ, Palczewski K, Takahashi M, Maeda A. PMID: 24129572; PMCID: PMC3843063.
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Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. J Biol Chem. 2013 Nov 22; 288(47):34081-34096. Amengual J, Widjaja-Adhi MAK, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J. PMID: 24106281; PMCID: PMC3837149.
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Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16586-91. Du Y, Veenstra A, Palczewski K, Kern TS. PMID: 24067647; PMCID: PMC3799310.
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Cellular retinaldehyde binding protein-different binding modes and micro-solvation patterns for high-affinity 9-cis- and 11-cis-retinal substrates. J Phys Chem B. 2013 Sep 19; 117(37):10719-29. Helbling RE, Bolze CS, Golczak M, Palczewski K, Stocker A, Cascella M. PMID: 23964907.
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Photoreceptor phagocytosis is mediated by phosphoinositide signaling. FASEB J. 2013 Nov; 27(11):4585-95. Mustafi D, Kevany BM, Genoud C, Bai X, Palczewski K. PMID: 23913857; PMCID: PMC3804748.
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Chemistry of the retinoid (visual) cycle. Chem Rev. 2014 Jan 08; 114(1):194-232. Kiser PD, Golczak M, Palczewski K. PMID: 23905688; PMCID: PMC3858459.
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In vivo two-photon imaging of the mouse retina. Biomed Opt Express. 2013; 4(8):1285-93. Sharma R, Yin L, Geng Y, Merigan WH, Palczewska G, Palczewski K, Williams DR, Hunter JJ. PMID: 24009992; PMCID: PMC3756587.
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Structural basis of carotenoid cleavage: from bacteria to mammals. Arch Biochem Biophys. 2013 Nov 15; 539(2):203-13. Sui X, Kiser PD, Lintig Jv, Palczewski K. PMID: 23827316; PMCID: PMC3818509.
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Characterization of human β,β-carotene-15,15'-monooxygenase (BCMO1) as a soluble monomeric enzyme. Arch Biochem Biophys. 2013 Nov 15; 539(2):214-22. Kowatz T, Babino D, Kiser P, Palczewski K, von Lintig J. PMID: 23727499; PMCID: PMC3795993.
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From atomic structures to neuronal functions of g protein-coupled receptors. Annu Rev Neurosci. 2013 Jul 08; 36:139-64. Palczewski K, Orban T. PMID: 23682660; PMCID: PMC4594856.
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Biochemistry. As good as chocolate. Science. 2013 May 03; 340(6132):562-3. Palczewski K, Kiser PD. PMID: 23641106; PMCID: PMC4596528.
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Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem. 2013 May 24; 288(21):15326-41. Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A. PMID: 23572532; PMCID: PMC3663552.
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Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter. Structure. 2013 May 07; 21(5):854-60. Tsybovsky Y, Orban T, Molday RS, Taylor D, Palczewski K. PMID: 23562398; PMCID: PMC3654078.
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Evolutionarily conserved long intergenic non-coding RNAs in the eye. Hum Mol Genet. 2013 Aug 01; 22(15):2992-3002. Mustafi D, Kevany BM, Bai X, Maeda T, Sears JE, Khalil AM, Palczewski K. PMID: 23562822; PMCID: PMC3699063.
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Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors. PLoS One. 2013; 8(3):e58832. Tian M, Zallocchi M, Wang W, Chen CK, Palczewski K, Delimont D, Cosgrove D, Peng YW. PMID: 23555598; PMCID: PMC3610756.
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The rhodopsin-transducin complex houses two distinct rhodopsin molecules. J Struct Biol. 2013 May; 182(2):164-72. Jastrzebska B, Ringler P, Palczewski K, Engel A. PMID: 23458690; PMCID: PMC3633645.
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Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection. J Biol Chem. 2013 Apr 12; 288(15):10406-17. Yan J, Kaur S, DeLucia M, Hao C, Mehrens J, Wang C, Golczak M, Palczewski K, Gronenborn AM, Ahn J, Skowronski J. PMID: 23426366; PMCID: PMC3624423.
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A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4). Mol Cell Proteomics. 2013 May; 12(5):1259-71. Padayatti PS, Wang L, Gupta S, Orban T, Sun W, Salom D, Jordan SR, Palczewski K, Chance MR. PMID: 23378516; PMCID: PMC3650337.
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QLT091001, a 9-cis-retinal analog, is well-tolerated by retinas of mice with impaired visual cycles. Invest Ophthalmol Vis Sci. 2013 Jan 17; 54(1):455-66. Maeda T, Dong Z, Jin H, Sawada O, Gao S, Utkhede D, Monk W, Palczewska G, Palczewski K. PMID: 23249702; PMCID: PMC4686220.
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Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J. 2013 Apr; 27(4):1572-84. Jastrzebska B, Orban T, Golczak M, Engel A, Palczewski K. PMID: 23303210; PMCID: PMC3606538.
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Expression of mammalian G protein-coupled receptors in Caenorhabditis elegans. Methods Enzymol. 2013; 520:239-56. Jastrzebska B, Salom D, Jin H, Cao P, Sun W, Palczewski K, Feng Z. PMID: 23332703; PMCID: PMC4112963.
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Crystallization of G protein-coupled receptors. Methods Cell Biol. 2013; 117:451-68. Salom D, Padayatti PS, Palczewski K. PMID: 24143992; PMCID: PMC4605854.
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Retinal degeneration in animal models with a defective visual cycle. Drug Discov Today Dis Models. 2013; 10(4):e163-e172. Maeda A, Palczewski K. PMID: 25210527; PMCID: PMC4157753.
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3D imaging and quantitative analysis of small solubilized membrane proteins and their complexes by transmission electron microscopy. Microscopy (Oxf). 2013 Feb; 62(1):95-107. Vahedi-Faridi A, Jastrzebska B, Palczewski K, Engel A. PMID: 23267047; PMCID: PMC3582345.
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G protein-coupled receptors--recent advances. Acta Biochim Pol. 2012; 59(4):515-29. Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S. PMID: 23251911; PMCID: PMC4322417.
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Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganization. J Clin Invest. 2013 Jan; 123(1):121-37. Zhang N, Kolesnikov AV, Jastrzebska B, Mustafi D, Sawada O, Maeda T, Genoud C, Engel A, Kefalov VJ, Palczewski K. PMID: 23221340; PMCID: PMC3533307.
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Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis. Proc Natl Acad Sci U S A. 2012 Oct 09; 109(41):E2747-56. Kiser PD, Farquhar ER, Shi W, Sui X, Chance MR, Palczewski K. PMID: 23012475; PMCID: PMC3478654.
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A microparticle/hydrogel combination drug-delivery system for sustained release of retinoids. Invest Ophthalmol Vis Sci. 2012 Sep 19; 53(10):6314-23. Gao SQ, Maeda T, Okano K, Palczewski K. PMID: 22918645; PMCID: PMC3465014.
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Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration. J Struct Biol. 2012 Dec; 180(3):439-46. Tu X, Palczewski K. PMID: 22892318; PMCID: PMC3496058.
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Inflammatory priming predisposes mice to age-related retinal degeneration. J Clin Invest. 2012 Aug; 122(8):2989-3001. Mustafi D, Maeda T, Kohno H, Nadeau JH, Palczewski K. PMID: 22797304; PMCID: PMC3408755.
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HIV-1 reverse transcriptase (RT) polymorphism 172K suppresses the effect of clinically relevant drug resistance mutations to both nucleoside and non-nucleoside RT inhibitors. J Biol Chem. 2012 Aug 24; 287(35):29988-99. Hachiya A, Marchand B, Kirby KA, Michailidis E, Tu X, Palczewski K, Ong YT, Li Z, Griffin DT, Schuckmann MM, Tanuma J, Oka S, Singh K, Kodama EN, Sarafianos SG. PMID: 22761416; PMCID: PMC3436141.
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Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding protein. J Biol Chem. 2012 Jul 13; 287(29):24216-27. Amengual J, Golczak M, Palczewski K, von Lintig J. PMID: 22637576; PMCID: PMC3397848.
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Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 2012 Jul 06; 287(28):23790-807. Golczak M, Kiser PD, Sears AE, Lodowski DT, Blaner WS, Palczewski K. PMID: 22605381; PMCID: PMC3390653.
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Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein. Structure. 2012 May 09; 20(5):826-40. Orban T, Jastrzebska B, Gupta S, Wang B, Miyagi M, Chance MR, Palczewski K. PMID: 22579250; PMCID: PMC3351692.
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Melanopsin is highly resistant to light and chemical bleaching in vivo. J Biol Chem. 2012 Jun 15; 287(25):20888-97. Sexton TJ, Golczak M, Palczewski K, Van Gelder RN. PMID: 22547062; PMCID: PMC3375512.
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Substrate-induced changes in the dynamics of rhodopsin kinase (G protein-coupled receptor kinase 1). Biochemistry. 2012 Apr 24; 51(16):3404-11. Orban T, Huang CC, Homan KT, Jastrzebska B, Tesmer JJ, Palczewski K. PMID: 22480180; PMCID: PMC3422436.
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The physiological impact of microRNA gene regulation in the retina. Cell Mol Life Sci. 2012 Aug; 69(16):2739-50. Sundermeier TR, Palczewski K. PMID: 22460583; PMCID: PMC3443797.
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Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase. J Biol Chem. 2012 Apr 13; 287(16):13356-70. Chen Y, Farquhar ER, Chance MR, Palczewski K, Kiser PD. PMID: 22356908; PMCID: PMC3339940.
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Imaging of protein crystals with two-photon microscopy. Biochemistry. 2012 Feb 28; 51(8):1625-37. Padayatti P, Palczewska G, Sun W, Palczewski K, Salom D. PMID: 22324807; PMCID: PMC3293215.
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Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage. J Neurochem. 2012 Apr; 121(1):146-56. Okano K, Maeda A, Chen Y, Chauhan V, Tang J, Palczewska G, Sakai T, Tsuneoka H, Palczewski K, Maeda T. PMID: 22220722; PMCID: PMC3303932.
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Primary amines protect against retinal degeneration in mouse models of retinopathies. Nat Chem Biol. 2011 Dec 25; 8(2):170-8. Maeda A, Golczak M, Chen Y, Okano K, Kohno H, Shiose S, Ishikawa K, Harte W, Palczewska G, Maeda T, Palczewski K. PMID: 22198730; PMCID: PMC3518042.
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Post-translational modifications of the serotonin type 4 receptor heterologously expressed in mouse rod cells. Biochemistry. 2012 Jan 10; 51(1):214-24. Salom D, Wang B, Dong Z, Sun W, Padayatti P, Jordan S, Salon JA, Palczewski K. PMID: 22145929; PMCID: PMC3268512.
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Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration. J Biol Chem. 2012 Feb 10; 287(7):5059-69. Chen Y, Okano K, Maeda T, Chauhan V, Golczak M, Maeda A, Palczewski K. PMID: 22184108; PMCID: PMC3281612.
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The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev. 2011 Dec; 63(4):901-37. Salon JA, Lodowski DT, Palczewski K. PMID: 21969326; PMCID: PMC3186081.
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Light-sensitive coupling of rhodopsin and melanopsin to G(i/o) and G(q) signal transduction in Caenorhabditis elegans. FASEB J. 2012 Feb; 26(2):480-91. Cao P, Sun W, Kramp K, Zheng M, Salom D, Jastrzebska B, Jin H, Palczewski K, Feng Z. PMID: 22090313; PMCID: PMC3290438.
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Heterologous expression of functional G-protein-coupled receptors in Caenorhabditis elegans. FASEB J. 2012 Feb; 26(2):492-502. Salom D, Cao P, Sun W, Kramp K, Jastrzebska B, Jin H, Feng Z, Palczewski K. PMID: 22090314; PMCID: PMC3290431.
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Thematic minireview series on focus on vision. J Biol Chem. 2012 Jan 13; 287(3):1610-1. Palczewski K. PMID: 22074916; PMCID: PMC3265840.
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Chemistry and biology of vision. J Biol Chem. 2012 Jan 13; 287(3):1612-9. Palczewski K. PMID: 22074921; PMCID: PMC3265841.
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Detergents stabilize the conformation of phosphodiesterase 6. Biochemistry. 2011 Nov 08; 50(44):9520-31. Baker BY, Palczewski K. PMID: 21978030; PMCID: PMC3215081.
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Rhodopsin-transducin heteropentamer: three-dimensional structure and biochemical characterization. J Struct Biol. 2011 Dec; 176(3):387-94. Jastrzebska B, Ringler P, Lodowski DT, Moiseenkova-Bell V, Golczak M, Müller SA, Palczewski K, Engel A. PMID: 21925606; PMCID: PMC3210324.
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Dietary 9-cis-β,β-carotene fails to rescue vision in mouse models of leber congenital amaurosis. Mol Pharmacol. 2011 Nov; 80(5):943-52. Maeda T, Perusek L, Amengual J, Babino D, Palczewski K, von Lintig J. PMID: 21862692; PMCID: PMC3198919.
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Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina. J Biol Chem. 2011 Sep 09; 286(36):31749-60. Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K. PMID: 21768104; PMCID: PMC3173082.
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Posttranslational modifications of the photoreceptor-specific ABC transporter ABCA4. Biochemistry. 2011 Aug 16; 50(32):6855-66. Tsybovsky Y, Wang B, Quazi F, Molday RS, Palczewski K. PMID: 21721517; PMCID: PMC3206228.
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Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration. FASEB J. 2011 Sep; 25(9):3157-76. Mustafi D, Kevany BM, Genoud C, Okano K, Cideciyan AV, Sumaroka A, Roman AJ, Jacobson SG, Engel A, Adams MD, Palczewski K. PMID: 21659555; PMCID: PMC3157681.
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Enzymatic properties and regulation of the native isozymes of retinal membrane guanylyl cyclase (RetGC) from mouse photoreceptors. Biochemistry. 2011 Jun 28; 50(25):5590-600. Peshenko IV, Olshevskaya EV, Savchenko AB, Karan S, Palczewski K, Baehr W, Dizhoor AM. PMID: 21598940; PMCID: PMC3127287.
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Heterogeneous N-terminal acylation of retinal proteins results from the retina's unusual lipid metabolism. Biochemistry. 2011 May 10; 50(18):3764-76. Bereta G, Palczewski K. PMID: 21449552; PMCID: PMC3086940.
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Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta. 2012 Jan; 1821(1):137-51. Kiser PD, Golczak M, Maeda A, Palczewski K. PMID: 21447403; PMCID: PMC3158816.
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Role of bulk water in hydrolysis of the rhodopsin chromophore. J Biol Chem. 2011 May 27; 286(21):18930-7. Jastrzebska B, Palczewski K, Golczak M. PMID: 21460218; PMCID: PMC3099708.
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Retinyl ester storage particles (retinosomes) from the retinal pigmented epithelium resemble lipid droplets in other tissues. J Biol Chem. 2011 May 13; 286(19):17248-58. Orban T, Palczewska G, Palczewski K. PMID: 21454509; PMCID: PMC3089567.
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Serial sectioning for examination of photoreceptor cell architecture by focused ion beam technology. J Neurosci Methods. 2011 May 15; 198(1):70-6. Mustafi D, Avishai A, Avishai N, Engel A, Heuer A, Palczewski K. PMID: 21439323; PMCID: PMC3090522.
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Role of membrane integrity on G protein-coupled receptors: Rhodopsin stability and function. Prog Lipid Res. 2011 Jul; 50(3):267-77. Jastrzebska B, Debinski A, Filipek S, Palczewski K. PMID: 21435354; PMCID: PMC3114187.
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Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice. J Biol Chem. 2011 Apr 29; 286(17):15543-55. Shiose S, Chen Y, Okano K, Roy S, Kohno H, Tang J, Pearlman E, Maeda T, Palczewski K, Maeda A. PMID: 21383019; PMCID: PMC3083179.
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Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 2011 Mar 22; 50(11):1940-9. Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. PMID: 21265573; PMCID: PMC3069497.
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Focus on vision: 3 decades of remarkable contributions to biology and medicine. FASEB J. 2011 Feb; 25(2):439-43. Palczewski K. PMID: 21282210; PMCID: PMC3228347.
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Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations. J Biol Chem. 2011 Mar 25; 286(12):10551-67. Sakami S, Maeda T, Bereta G, Okano K, Golczak M, Sumaroka A, Roman AJ, Cideciyan AV, Jacobson SG, Palczewski K. PMID: 21224384; PMCID: PMC3060508.
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Images of photoreceptors in living primate eyes using adaptive optics two-photon ophthalmoscopy. Biomed Opt Express. 2010 Dec 17; 2(1):139-48. Hunter JJ, Masella B, Dubra A, Sharma R, Yin L, Merigan WH, Palczewska G, Palczewski K, Williams DR. PMID: 21326644; PMCID: PMC3028489.
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Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1. J Biol Chem. 2011 Feb 18; 286(7):5607-13. Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA. PMID: 21159775; PMCID: PMC3037674.
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A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J. 2011 Mar; 25(3):948-59. Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J. PMID: 21106934; PMCID: PMC3042841.
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Noninvasive multiphoton fluorescence microscopy resolves retinol and retinal condensation products in mouse eyes. Nat Med. 2010 Dec; 16(12):1444-9. Palczewska G, Maeda T, Imanishi Y, Sun W, Chen Y, Williams DR, Piston DW, Maeda A, Palczewski K. PMID: 21076393; PMCID: PMC3057900.
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Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle. Arch Ophthalmol. 2010 Nov; 128(11):1483-5. Palczewski K. PMID: 21060052; PMCID: PMC4495581.
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Conformational changes in the g protein-coupled receptor rhodopsin revealed by histidine hydrogen-deuterium exchange. Biochemistry. 2010 Nov 09; 49(44):9425-7. Lodowski DT, Palczewski K, Miyagi M. PMID: 20939497; PMCID: PMC3075965.
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Vitamin A deficiency results in meiotic failure and accumulation of undifferentiated spermatogonia in prepubertal mouse testis. Biol Reprod. 2011 Feb; 84(2):336-41. Li H, Palczewski K, Baehr W, Clagett-Dame M. PMID: 20881313; PMCID: PMC3071267.
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Characterization of the secondary binding sites of Maclura pomifera agglutinin by glycan array and crystallographic analyses. Glycobiology. 2010 Dec; 20(12):1643-53. Huang J, Xu Z, Wang D, Ogata CM, Palczewski K, Lee X, Young NM. PMID: 20826825; PMCID: PMC3003548.
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Electrostatic compensation restores trafficking of the autosomal recessive retinitis pigmentosa E150K opsin mutant to the plasma membrane. J Biol Chem. 2010 Sep 17; 285(38):29446-56. Pulagam LP, Palczewski K. PMID: 20628051; PMCID: PMC2937977.
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An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase. J Biol Chem. 2010 Sep 17; 285(38):29217-22. Golczak M, Palczewski K. PMID: 20628054; PMCID: PMC2937952.
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Structural characterization of the rod cGMP phosphodiesterase 6. J Mol Biol. 2010 Aug 20; 401(3):363-73. Goc A, Chami M, Lodowski DT, Bosshart P, Moiseenkova-Bell V, Baehr W, Engel A, Palczewski K. PMID: 20600113; PMCID: PMC2917047.
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Beta,beta-carotene decreases peroxisome proliferator receptor gamma activity and reduces lipid storage capacity of adipocytes in a beta,beta-carotene oxygenase 1-dependent manner. J Biol Chem. 2010 Sep 03; 285(36):27891-9. Lobo GP, Amengual J, Li HN, Golczak M, Bonet ML, Palczewski K, von Lintig J. PMID: 20573961; PMCID: PMC2934656.
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Oligomeric forms of G protein-coupled receptors (GPCRs). Trends Biochem Sci. 2010 Nov; 35(11):595-600. Palczewski K. PMID: 20538466; PMCID: PMC2937196.
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Retinoids for treatment of retinal diseases. Trends Pharmacol Sci. 2010 Jun; 31(6):284-95. Palczewski K. PMID: 20435355; PMCID: PMC2882531.
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GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 Jul 15; 26(14):1804-5. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. PMID: 20501551; PMCID: PMC2894509.
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Complexes between photoactivated rhodopsin and transducin: progress and questions. Biochem J. 2010 Apr 28; 428(1):1-10. Jastrzebska B, Tsybovsky Y, Palczewski K. PMID: 20423327; PMCID: PMC2875673.
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Palmitoylation stabilizes unliganded rod opsin. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8428-33. Maeda A, Okano K, Park PS, Lem J, Crouch RK, Maeda T, Palczewski K. PMID: 20404157; PMCID: PMC2889565.
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Membrane-binding and enzymatic properties of RPE65. Prog Retin Eye Res. 2010 Sep; 29(5):428-42. Kiser PD, Palczewski K. PMID: 20304090; PMCID: PMC2903629.
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The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision. Trends Biochem Sci. 2010 Jul; 35(7):400-10. von Lintig J, Kiser PD, Golczak M, Palczewski K. PMID: 20188572; PMCID: PMC2891588.
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Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. PLoS One. 2010 Feb 19; 5(2):e9312. Cao P, Yuan Y, Pehek EA, Moise AR, Huang Y, Palczewski K, Feng Z. PMID: 20174477; PMCID: PMC2824852.
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Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. Biochemistry. 2010 Feb 09; 49(5):827-34. Orban T, Gupta S, Palczewski K, Chance MR. PMID: 20047303; PMCID: PMC2819031.
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Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda). 2010 Feb; 25(1):8-15. Kevany BM, Palczewski K. PMID: 20134024; PMCID: PMC2839896.
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Importance of membrane structural integrity for RPE65 retinoid isomerization activity. J Biol Chem. 2010 Mar 26; 285(13):9667-9682. Golczak M, Kiser PD, Lodowski DT, Maeda A, Palczewski K. PMID: 20100834; PMCID: PMC2843217.
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Conformational changes in guanylate cyclase-activating protein 1 induced by Ca2+ and N-terminal fatty acid acylation. Structure. 2010 Jan 13; 18(1):116-26. Orban T, Bereta G, Miyagi M, Wang B, Chance MR, Sousa MC, Palczewski K. PMID: 20152158; PMCID: PMC2822722.
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ISX is a retinoic acid-sensitive gatekeeper that controls intestinal beta,beta-carotene absorption and vitamin A production. FASEB J. 2010 Jun; 24(6):1656-66. Lobo GP, Hessel S, Eichinger A, Noy N, Moise AR, Wyss A, Palczewski K, von Lintig J. PMID: 20061533; PMCID: PMC2874479.
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Molecular biology and analytical chemistry methods used to probe the retinoid cycle. Methods Mol Biol. 2010; 652:229-45. Golczak M, Bereta G, Maeda A, Palczewski K. PMID: 20552432; PMCID: PMC4607022.
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Visualization of retinoid storage and trafficking by two-photon microscopy. Methods Mol Biol. 2010; 652:247-61. Imanishi Y, Palczewski K. PMID: 20552433; PMCID: PMC4607074.
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The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal disease. Adv Exp Med Biol. 2010; 703:105-25. Tsybovsky Y, Molday RS, Palczewski K. PMID: 20711710; PMCID: PMC2930353.
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Multiple pathways ensure retinoid delivery to milk: studies in genetically modified mice. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E862-70. O'Byrne SM, Kako Y, Deckelbaum RJ, Hansen IH, Palczewski K, Goldberg IJ, Blaner WS. PMID: 20040693; PMCID: PMC2853214.
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Increased adiposity in the retinol saturase-knockout mouse. FASEB J. 2010 Apr; 24(4):1261-70. Moise AR, Lobo GP, Erokwu B, Wilson DL, Peck D, Alvarez S, Domínguez M, Alvarez R, Flask CA, de Lera AR, von Lintig J, Palczewski K. PMID: 19940255; PMCID: PMC2845435.
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A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem. 2010 Jan 15; 285(3):1899-908. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K. PMID: 19901021; PMCID: PMC2804348.
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Crystal structure of native RPE65, the retinoid isomerase of the visual cycle. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17325-30. Kiser PD, Golczak M, Lodowski DT, Chance MR, Palczewski K. PMID: 19805034; PMCID: PMC2765077.
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Activation of retinoic acid receptors by dihydroretinoids. Mol Pharmacol. 2009 Dec; 76(6):1228-37. Moise AR, Alvarez S, Domínguez M, Alvarez R, Golczak M, Lobo GP, von Lintig J, de Lera AR, Palczewski K. PMID: 19770350; PMCID: PMC2784734.
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Use of thallium to identify monovalent cation binding sites in GroEL. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Oct 01; 65(Pt 10):967-71. Kiser PD, Lorimer GH, Palczewski K. PMID: 19851000; PMCID: PMC2765879.
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Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14367-72. Angel TE, Gupta S, Jastrzebska B, Palczewski K, Chance MR. PMID: 19706523; PMCID: PMC2732891.
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WITHDRAWN: Retinol dehydrogenase RDH11 protects the mouse retina from light-induced degeneration. Invest Ophthalmol Vis Sci. 2009 Aug 13. Maeda A, Shiose S, Okano K, Matosky M, Maeda T, Palczewski K. PMID: 19458342.
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Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5435-43. Maeda A, Golczak M, Maeda T, Palczewski K. PMID: 19553623; PMCID: PMC2792889.
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Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex. Biochemistry. 2009 Jun 16; 48(23):5159-70. Jastrzebska B, Goc A, Golczak M, Palczewski K. PMID: 19413332; PMCID: PMC2753473.
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Structure of cone photoreceptors. Prog Retin Eye Res. 2009 Jul; 28(4):289-302. Mustafi D, Engel AH, Palczewski K. PMID: 19501669; PMCID: PMC2740621.
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Evaluation of potential therapies for a mouse model of human age-related macular degeneration caused by delayed all-trans-retinal clearance. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4917-25. Maeda T, Maeda A, Matosky M, Okano K, Roos S, Tang J, Palczewski K. PMID: 19494204; PMCID: PMC2782428.
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Modulation of molecular interactions and function by rhodopsin palmitylation. Biochemistry. 2009 May 26; 48(20):4294-304. Park PS, Sapra KT, Jastrzebska B, Maeda T, Maeda A, Pulawski W, Kono M, Lem J, Crouch RK, Filipek S, Müller DJ, Palczewski K. PMID: 19348429; PMCID: PMC2710298.
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Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors. Proc Natl Acad Sci U S A. 2009 May 26; 106(21):8555-60. Angel TE, Chance MR, Palczewski K. PMID: 19433801; PMCID: PMC2688986.
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Clarin-1, encoded by the Usher Syndrome III causative gene, forms a membranous microdomain: possible role of clarin-1 in organizing the actin cytoskeleton. J Biol Chem. 2009 Jul 10; 284(28):18980-93. Tian G, Zhou Y, Hajkova D, Miyagi M, Dinculescu A, Hauswirth WW, Palczewski K, Geng R, Alagramam KN, Isosomppi J, Sankila EM, Flannery JG, Imanishi Y. PMID: 19423712; PMCID: PMC2707243.
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Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 01; 18(15):2748-60. Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. PMID: 19414487; PMCID: PMC2706682.
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Evaluation of 9-cis-retinyl acetate therapy in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4368-78. Maeda T, Maeda A, Casadesus G, Palczewski K, Margaron P. PMID: 19407008; PMCID: PMC2764364.
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Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum Mol Genet. 2009 Jun 15; 18(12):2277-87. Maeda T, Cideciyan AV, Maeda A, Golczak M, Aleman TS, Jacobson SG, Palczewski K. PMID: 19339306; PMCID: PMC2685761.
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Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem. 2009 May 29; 284(22):15173-83. Maeda A, Maeda T, Golczak M, Chou S, Desai A, Hoppel CL, Matsuyama S, Palczewski K. PMID: 19304658; PMCID: PMC2685698.
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Chemokine receptors and other G protein-coupled receptors. Curr Opin HIV AIDS. 2009 Mar; 4(2):88-95. Lodowski DT, Palczewski K. PMID: 19339946; PMCID: PMC2771364.
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Comparative analysis of GPCR crystal structures. Photochem Photobiol. 2009 Mar-Apr; 85(2):425-30. Lodowski DT, Angel TE, Palczewski K. PMID: 19192200; PMCID: PMC2681091.
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Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res. 2009 Jun 15; 89(1):2-3. Baehr W, Palczewski K. PMID: 19162008; PMCID: PMC2739054.
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Heterologous expression and purification of the serotonin type 4 receptor from transgenic mouse retina. Biochemistry. 2008 Dec 16; 47(50):13296-307. Salom D, Wu N, Sun W, Dong Z, Palczewski K, Jordan S, Salon JA. PMID: 19053287.
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ABCA4 disease progression and a proposed strategy for gene therapy. Hum Mol Genet. 2009 Mar 01; 18(5):931-41. Cideciyan AV, Swider M, Aleman TS, Tsybovsky Y, Schwartz SB, Windsor EA, Roman AJ, Sumaroka A, Steinberg JD, Jacobson SG, Stone EM, Palczewski K. PMID: 19074458; PMCID: PMC2640207.
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Different properties of the native and reconstituted heterotrimeric G protein transducin. Biochemistry. 2008 Nov 25; 47(47):12409-19. Goc A, Angel TE, Jastrzebska B, Wang B, Wintrode PL, Palczewski K. PMID: 18975915; PMCID: PMC2645919.
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Structural insights into Ca2+-dependent regulation of inositol 1,4,5-trisphosphate receptors by CaBP1. J Biol Chem. 2009 Jan 23; 284(4):2472-81. Li C, Chan J, Haeseleer F, Mikoshiba K, Palczewski K, Ikura M, Ames JB. PMID: 19008222; PMCID: PMC2629100.
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Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors. Mol Pharmacol. 2009 Jan; 75(1):1-12. Mustafi D, Palczewski K. PMID: 18945819; PMCID: PMC2652756.
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Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB J. 2009 Feb; 23(2):371-81. Jastrzebska B, Golczak M, Fotiadis D, Engel A, Palczewski K. PMID: 18827025; PMCID: PMC2630779.
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A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res. 2008 Oct; 48(23-24):2425-32. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W. PMID: 18706439; PMCID: PMC2584361.
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Impact of retinal disease-associated RPE65 mutations on retinoid isomerization. Biochemistry. 2008 Sep 16; 47(37):9856-65. Bereta G, Kiser PD, Golczak M, Sun W, Heon E, Saperstein DA, Palczewski K. PMID: 18722466; PMCID: PMC2610467.
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Effects of long-term administration of 9-cis-retinyl acetate on visual function in mice. Invest Ophthalmol Vis Sci. 2009 Jan; 50(1):322-33. Maeda T, Maeda A, Leahy P, Saperstein DA, Palczewski K. PMID: 18708622; PMCID: PMC2615069.
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Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem. 2008 Sep 26; 283(39):26684-93. Maeda A, Maeda T, Golczak M, Palczewski K. PMID: 18658157; PMCID: PMC2546559.
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Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina. J Biol Chem. 2008 Sep 05; 283(36):25091-102. Imanishi Y, Sun W, Maeda T, Maeda A, Palczewski K. PMID: 18606814; PMCID: PMC2529016.
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Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci. 2008 Apr 09; 28(15):4008-14. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W. PMID: 18400900; PMCID: PMC2562706.
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The molecular basis of retinoid absorption: a genetic dissection. J Biol Chem. 2008 May 16; 283(20):13510-9. Wongsiriroj N, Piantedosi R, Palczewski K, Goldberg IJ, Johnston TP, Li E, Blaner WS. PMID: 18348983; PMCID: PMC2376245.
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Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. J Biol Chem. 2008 May 16; 283(20):14053-62. Singh P, Wang B, Maeda T, Palczewski K, Tesmer JJ. PMID: 18339619; PMCID: PMC2376226.
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Ca2+ -dependent regulation of phototransduction. Photochem Photobiol. 2008 Jul-Aug; 84(4):903-10. Stephen R, Filipek S, Palczewski K, Sousa MC. PMID: 18346093; PMCID: PMC4118144.
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Vertebrate membrane proteins: structure, function, and insights from biophysical approaches. Pharmacol Rev. 2008 Mar; 60(1):43-78. Müller DJ, Wu N, Palczewski K. PMID: 18321962; PMCID: PMC2561275.
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RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome. Cell Metab. 2008 Mar; 7(3):258-68. Isken A, Golczak M, Oberhauser V, Hunzelmann S, Driever W, Imanishi Y, Palczewski K, von Lintig J. PMID: 18316031; PMCID: PMC2561276.
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Mechanical properties of bovine rhodopsin and bacteriorhodopsin: possible roles in folding and function. Langmuir. 2008 Feb 19; 24(4):1330-7. Sapra KT, Park PS, Palczewski K, Muller DJ. PMID: 18266338; PMCID: PMC2504747.
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Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retina. J Biol Chem. 2008 Apr 11; 283(15):9543-54. Golczak M, Maeda A, Bereta G, Maeda T, Kiser PD, Hunzelmann S, von Lintig J, Blaner WS, Palczewski K. PMID: 18195010; PMCID: PMC2441898.
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Stereospecificity of retinol saturase: absolute configuration, synthesis, and biological evaluation of dihydroretinoids. J Am Chem Soc. 2008 Jan 30; 130(4):1154-5. Moise AR, Domínguez M, Alvarez S, Alvarez R, Schupp M, Cristancho AG, Kiser PD, de Lera AR, Lazar MA, Palczewski K. PMID: 18179220; PMCID: PMC2621334.
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Activation of G protein-coupled receptors: beyond two-state models and tertiary conformational changes. Annu Rev Pharmacol Toxicol. 2008; 48:107-41. Park PS, Lodowski DT, Palczewski K. PMID: 17848137; PMCID: PMC2639654.
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Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008 Feb 29; 283(9):5611-21. Kim YK, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner WS, Quadro L. PMID: 18093970; PMCID: PMC3771510.
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Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A. 2007 Dec 04; 104(49):19565-70. Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K. PMID: 18048336; PMCID: PMC2148329.
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Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. J Biol Chem. 2008 Feb 15; 283(7):4387-94. Whorton MR, Jastrzebska B, Park PS, Fotiadis D, Engel A, Palczewski K, Sunahara RK. PMID: 18033822; PMCID: PMC2651572.
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Stabilizing function for myristoyl group revealed by the crystal structure of a neuronal calcium sensor, guanylate cyclase-activating protein 1. Structure. 2007 Nov; 15(11):1392-402. Stephen R, Bereta G, Golczak M, Palczewski K, Sousa MC. PMID: 17997965; PMCID: PMC2556213.
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Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007 Oct; 26(7):1940-9. Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SC, von Lintig J. PMID: 17868371; PMCID: PMC2435297.
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Human cone photoreceptor dependence on RPE65 isomerase. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15123-8. Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. PMID: 17848510; PMCID: PMC1986623.
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Reprint of "Crystal packing analysis of Rhodopsin crystals" [J. Struct. Biol. 158 (2007) 455-462]. J Struct Biol. 2007 Aug; 159(2):253-60. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. PMID: 17660064.
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Heterologous expression of the adenosine A1 receptor in transgenic mouse retina. Biochemistry. 2007 Jul 17; 46(28):8350-9. Li N, Salom D, Zhang L, Harris T, Ballesteros JA, Golczak M, Jastrzebska B, Palczewski K, Kurahara C, Juan T, Jordan S, Salon JA. PMID: 17580959.
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Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30; 8:177. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M. PMID: 17537266; PMCID: PMC1904246.
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Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomography. J Cell Biol. 2007 Jun 04; 177(5):917-25. Nickell S, Park PS, Baumeister W, Palczewski K. PMID: 17535966; PMCID: PMC2064290.
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Novel RDH12 mutations associated with Leber congenital amaurosis and cone-rod dystrophy: biochemical and clinical evaluations. Vision Res. 2007 Jul; 47(15):2055-66. Sun W, Gerth C, Maeda A, Lodowski DT, Van Der Kraak L, Saperstein DA, Héon E, Palczewski K. PMID: 17512964; PMCID: PMC2441904.
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Purification, crystallization and structure determination of native GroEL from Escherichia coli lacking bound potassium ions. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jun 01; 63(Pt 6):457-61. Kiser PD, Lodowski DT, Palczewski K. PMID: 17554162; PMCID: PMC2335072.
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Delivery of retinoid-based therapies to target tissues. Biochemistry. 2007 Apr 17; 46(15):4449-58. Moise AR, Noy N, Palczewski K, Blaner WS. PMID: 17378589; PMCID: PMC2562735.
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International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev. 2007 Mar; 59(1):5-13. Pin JP, Neubig R, Bouvier M, Devi L, Filizola M, Javitch JA, Lohse MJ, Milligan G, Palczewski K, Parmentier M, Spedding M. PMID: 17329545.
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Stabilizing effect of Zn2+ in native bovine rhodopsin. J Biol Chem. 2007 Apr 13; 282(15):11377-85. Park PS, Sapra KT, Kolinski M, Filipek S, Palczewski K, Muller DJ. PMID: 17303564; PMCID: PMC2043472.
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Crystal packing analysis of Rhodopsin crystals. J Struct Biol. 2007 Jun; 158(3):455-62. Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, Stenkamp RE. PMID: 17374491; PMCID: PMC1950280.
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Visual rhodopsin sees the light: structure and mechanism of G protein signaling. J Biol Chem. 2007 Mar 30; 282(13):9297-9301. Ridge KD, Palczewski K. PMID: 17289671.
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Specificity of zebrafish retinol saturase: formation of all-trans-13,14-dihydroretinol and all-trans-7,8- dihydroretinol. Biochemistry. 2007 Feb 20; 46(7):1811-20. Moise AR, Isken A, Domínguez M, de Lera AR, von Lintig J, Palczewski K. PMID: 17253779; PMCID: PMC2561287.
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The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem. 2007 Mar 23; 282(12):8837-47. Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K. PMID: 17255100; PMCID: PMC2043484.
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Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agents. Annu Rev Pharmacol Toxicol. 2007; 47:469-512. Travis GH, Golczak M, Moise AR, Palczewski K. PMID: 16968212; PMCID: PMC2442882.
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Guanylate cyclase-activating proteins and retina disease. Subcell Biochem. 2007; 45:71-91. Baehr W, Palczewski K. PMID: 18193635.
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Topology and membrane association of lecithin: retinol acyltransferase. J Biol Chem. 2007 Jan 19; 282(3):2081-90. Moise AR, Golczak M, Imanishi Y, Palczewski K. PMID: 17114808.
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Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. J Biol Chem. 2007 Jan 12; 282(2):1144-51. Isken A, Holzschuh J, Lampert JM, Fischer L, Oberhauser V, Palczewski K, von Lintig J. PMID: 17098734.
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The role of the 11-cis-retinal ring methyl substituents in visual pigment formation. Chembiochem. 2006 Nov; 7(11):1815-25. Domínguez M, Alvarez R, Pérez M, Palczewski K, de Lera AR. PMID: 16941510.
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Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16123-8. Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K. PMID: 17060607; PMCID: PMC1637547.
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Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem. 2006 Dec 08; 281(49):37697-704. Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K. PMID: 17032653; PMCID: PMC4124513.
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Improvement in rod and cone function in mouse model of Fundus albipunctatus after pharmacologic treatment with 9-cis-retinal. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4540-6. Maeda A, Maeda T, Palczewski K. PMID: 17003450; PMCID: PMC1764978.
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Light-driven cone arrestin translocation in cones of postnatal guanylate cyclase-1 knockout mouse retina treated with AAV-GC1. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3745-53. Haire SE, Pang J, Boye SL, Sokal I, Craft CM, Palczewski K, Hauswirth WW, Semple-Rowland SL. PMID: 16936082; PMCID: PMC1761699.
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Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in mice. Mol Pharmacol. 2006 Oct; 70(4):1220-9. Maeda A, Maeda T, Golczak M, Imanishi Y, Leahy P, Kubota R, Palczewski K. PMID: 16837623; PMCID: PMC4106413.
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Inner retinal photoreception independent of the visual retinoid cycle. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10426-10431. Tu DC, Owens LA, Anderson L, Golczak M, Doyle SE, McCall M, Menaker M, Palczewski K, Van Gelder RN. PMID: 16788071; PMCID: PMC1502474.
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Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J Struct Biol. 2006 Dec; 156(3):497-504. Salom D, Le Trong I, Pohl E, Ballesteros JA, Stenkamp RE, Palczewski K, Lodowski DT. PMID: 16837211.
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Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene. J Biol Chem. 2006 Aug 04; 281(31):22289-22298. Zhu L, Imanishi Y, Filipek S, Alekseev A, Jastrzebska B, Sun W, Saperstein DA, Palczewski K. PMID: 16737970; PMCID: PMC1618956.
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Lentiviral expression of retinal guanylate cyclase-1 (RetGC1) restores vision in an avian model of childhood blindness. PLoS Med. 2006 Jun; 3(6):e201. Williams ML, Coleman JE, Haire SE, Aleman TS, Cideciyan AV, Sokal I, Palczewski K, Jacobson SG, Semple-Rowland SL. PMID: 16700630; PMCID: PMC1463903.
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Aberrant metabolites in mouse models of congenital blinding diseases: formation and storage of retinyl esters. Biochemistry. 2006 Apr 04; 45(13):4210-9. Maeda A, Maeda T, Imanishi Y, Golczak M, Moise AR, Palczewski K. PMID: 16566595; PMCID: PMC1560103.
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The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies. J Mol Biol. 2006 Jun 02; 359(2):266-75. Stephen R, Palczewski K, Sousa MC. PMID: 16626734; PMCID: PMC4291230.
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Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol. 2006 Apr; 16(2):252-9. Fotiadis D, Jastrzebska B, Philippsen A, Müller DJ, Palczewski K, Engel A. PMID: 16567090.
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Functional and structural characterization of rhodopsin oligomers. J Biol Chem. 2006 Apr 28; 281(17):11917-22. Jastrzebska B, Fotiadis D, Jang GF, Stenkamp RE, Engel A, Palczewski K. PMID: 16495215; PMCID: PMC1618955.
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Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3060-5. Mansoor SE, Palczewski K, Farrens DL. PMID: 16492772; PMCID: PMC1413906.
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Detecting molecular interactions that stabilize native bovine rhodopsin. J Mol Biol. 2006 Apr 21; 358(1):255-69. Tanuj Sapra K, Park PS, Filipek S, Engel A, Müller DJ, Palczewski K. PMID: 16519899.
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G protein-coupled receptor rhodopsin. Annu Rev Biochem. 2006; 75:743-67. Palczewski K. PMID: 16756510; PMCID: PMC1560097.
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Arrestin interaction with rhodopsin: conceptual models. Cell Biochem Biophys. 2006; 46(1):1-15. Modzelewska A, Filipek S, Palczewski K, Park PS. PMID: 16943619.
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Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis. Biochemistry. 2005 Nov 08; 44(44):14509-18. Zhang L, Salom D, He J, Okun A, Ballesteros J, Palczewski K, Li N. PMID: 16262251.
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Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med. 2005 Nov; 2(11):e333. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K. PMID: 16250670; PMCID: PMC1274279.
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A critical role of CaBP4 in the cone synapse. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4320-7. Maeda T, Lem J, Palczewski K, Haeseleer F. PMID: 16249514; PMCID: PMC1351246.
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Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Mol Ther. 2005 Dec; 12(6):1072-82. Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. PMID: 16226919; PMCID: PMC3647373.
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Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle. J Biol Chem. 2005 Dec 23; 280(51):42263-73. Golczak M, Imanishi Y, Kuksa V, Maeda T, Kubota R, Palczewski K. PMID: 16216874.
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Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. J Biol Chem. 2005 Nov 11; 280(45):37461-70. Wingard JN, Chan J, Bosanac I, Haeseleer F, Palczewski K, Ikura M, Ames JB. PMID: 16147998; PMCID: PMC1470661.
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Imaging G protein-coupled receptor islands. Nat Chem Biol. 2005 Sep; 1(4):184-5. Park PS, Palczewski K. PMID: 16408027.
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Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem. 2005 Oct 21; 280(42):35647-57. O'Byrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS. PMID: 16115871; PMCID: PMC1352312.
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Partial agonism in a G Protein-coupled receptor: role of the retinal ring structure in rhodopsin activation. J Biol Chem. 2005 Oct 07; 280(40):34259-67. Bartl FJ, Fritze O, Ritter E, Herrmann R, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. PMID: 16027155.
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Diversifying the repertoire of G protein-coupled receptors through oligomerization. Proc Natl Acad Sci U S A. 2005 Jun 21; 102(25):8793-4. Park PS, Palczewski K. PMID: 15956197; PMCID: PMC1157063.
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Rhodopsin: a structural primer for G-protein coupled receptors. Arch Pharm (Weinheim). 2005 Jun; 338(5-6):209-16. Stenkamp RE, Teller DC, Palczewski K. PMID: 15952240.
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Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8162-7. Golczak M, Kuksa V, Maeda T, Moise AR, Palczewski K. PMID: 15917330; PMCID: PMC1149451.
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Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem. 2005 Jul 29; 280(30):27815-25. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K. PMID: 15911617; PMCID: PMC1352314.
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Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success. Proc Natl Acad Sci U S A. 2005 Apr 26; 102(17):6177-82. Jacobson SG, Aleman TS, Cideciyan AV, Sumaroka A, Schwartz SB, Windsor EA, Traboulsi EI, Heon E, Pittler SJ, Milam AH, Maguire AM, Palczewski K, Stone EM, Bennett J. PMID: 15837919; PMCID: PMC1087926.
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A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1124-32. Sokal I, Dupps WJ, Grassi MA, Brown J, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W. PMID: 15790869; PMCID: PMC1352313.
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Related enzymes solve evolutionarily recurrent problems in the metabolism of carotenoids. Trends Plant Sci. 2005 Apr; 10(4):178-86. Moise AR, von Lintig J, Palczewski K. PMID: 15817419.
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Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem. 2005 May 13; 280(19):18822-32. Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K. PMID: 15755727; PMCID: PMC1283069.
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Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. Biochemistry. 2005 Jan 18; 44(2):480-9. Maeda A, Crabb JW, Palczewski K. PMID: 15641772; PMCID: PMC1351247.
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Delayed dark adaptation in 11-cis-retinol dehydrogenase-deficient mice: a role of RDH11 in visual processes in vivo. J Biol Chem. 2005 Mar 11; 280(10):8694-704. Kim TS, Maeda A, Maeda T, Heinlein C, Kedishvili N, Palczewski K, Nelson PS. PMID: 15634683; PMCID: PMC1351245.
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Oligomerization of G protein-coupled receptors: past, present, and future. Biochemistry. 2004 Dec 21; 43(50):15643-56. Park PS, Filipek S, Wells JW, Palczewski K. PMID: 15595821; PMCID: PMC1752221.
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A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3863-70. Nishiguchi KM, Sokal I, Yang L, Roychowdhury N, Palczewski K, Berson EL, Dryja TP, Baehr W. PMID: 15505030; PMCID: PMC1475955.
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The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol. 2004 Nov-Dec; 21(6):435-46. Suda K, Filipek S, Palczewski K, Engel A, Fotiadis D. PMID: 15764373; PMCID: PMC1351286.
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Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem. 2004 Dec 24; 279(52):54663-75. Jastrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K. PMID: 15489507; PMCID: PMC1351296.
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Hippocalcin in the olfactory epithelium: a mediator of second messenger signaling. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1131-9. Mammen A, Simpson PJ, Mamman A, Simpson JP, Nighorn A, Imanishi Y, Palczewski K, Ronnett GV, Moon C. PMID: 15336960.
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Nonvisual photoreception in the chick iris. Science. 2004 Oct 01; 306(5693):129-31. Tu DC, Batten ML, Palczewski K, Van Gelder RN. PMID: 15459395.
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Guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1123-30. Palczewski K, Sokal I, Baehr W. PMID: 15336959.
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A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. J Biol Chem. 2004 Dec 17; 279(51):53828-39. Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. PMID: 15459196; PMCID: PMC1351288.
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Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Nat Neurosci. 2004 Oct; 7(10):1079-87. Haeseleer F, Imanishi Y, Maeda T, Possin DE, Maeda A, Lee A, Rieke F, Palczewski K. PMID: 15452577; PMCID: PMC1352161.
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Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. J Biol Chem. 2004 Nov 26; 279(48):50230-42. Moise AR, Kuksa V, Imanishi Y, Palczewski K. PMID: 15358783; PMCID: PMC2665716.
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Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry. 2004 Sep 07; 43(35):11175-86. Subramanian L, Crabb JW, Cox J, Durussel I, Walker TM, van Ginkel PR, Bhattacharya S, Dellaria JM, Palczewski K, Polans AS. PMID: 15366927; PMCID: PMC1351334.
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Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice. J Biol Chem. 2004 Nov 12; 279(46):48189-96. Liang Y, Fotiadis D, Maeda T, Maeda A, Modzelewska A, Filipek S, Saperstein DA, Engel A, Palczewski K. PMID: 15337746; PMCID: PMC1351248.
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Retinosomes: new insights into intracellular managing of hydrophobic substances in lipid bodies. J Cell Biol. 2004 Aug 16; 166(4):447-53. Imanishi Y, Gerke V, Palczewski K. PMID: 15314061; PMCID: PMC1360213.
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Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol. 2004 Aug; 59(2):204-217. Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W. PMID: 15486694; PMCID: PMC1351297.
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The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett. 2004 Apr 30; 564(3):281-288. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. PMID: 15111110; PMCID: PMC1393389.
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Impairment of the transient pupillary light reflex in Rpe65(-/-) mice and humans with leber congenital amaurosis. Invest Ophthalmol Vis Sci. 2004 Apr; 45(4):1259-71. Aleman TS, Jacobson SG, Chico JD, Scott ML, Cheung AY, Windsor EA, Furushima M, Redmond TM, Bennett J, Palczewski K, Cideciyan AV. PMID: 15037595.
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A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci. 2004 Jun; 3(6):628-38. Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K. PMID: 15170495.
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Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol. 2004 Feb 02; 164(3):373-83. Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K. PMID: 14745001; PMCID: PMC1360214.
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Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem. 2004 Mar 12; 279(11):10422-32. Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K. PMID: 14684738; PMCID: PMC1351249.
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Retinoid cycle in the vertebrate retina: experimental approaches and mechanisms of isomerization. Vision Res. 2003 Dec; 43(28):2959-81. Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. PMID: 14611933.
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The retinoid cycle and retina disease. Vision Res. 2003 Dec; 43(28):2957-8. Baehr W, Wu SM, Bird AC, Palczewski K. PMID: 14611932.
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Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res. 2003 Dec; 43(28):3075-9. Driessen C, Winkens H, Haeseleer F, Palczewski K, Janssen J. PMID: 14611944.
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Evolutionary analysis of rhodopsin and cone pigments: connecting the three-dimensional structure with spectral tuning and signal transfer. FEBS Lett. 2003 Nov 27; 555(1):151-9. Teller DC, Stenkamp RE, Palczewski K. PMID: 14630336; PMCID: PMC1468034.
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Phototransduction: crystal clear. Trends Biochem Sci. 2003 Sep; 28(9):479-87. Ridge KD, Abdulaev NG, Sousa M, Palczewski K. PMID: 13678959.
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Albipunctate retinopathy with cone dysfunction and no abnormality in the RDH5 or RLBP1 genes. Retina. 2003 Aug; 23(4):543-6. Marmor MF, Haeseleer F, Palczewski K. PMID: 12972770.
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Rhodopsin phosphorylation: 30 years later. Prog Retin Eye Res. 2003 Jul; 22(4):417-34. Maeda T, Imanishi Y, Palczewski K. PMID: 12742390.
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Evaluation of the role of the retinal G protein-coupled receptor (RGR) in the vertebrate retina in vivo. J Neurochem. 2003 May; 85(4):944-56. Maeda T, Van Hooser JP, Driessen CA, Filipek S, Janssen JJ, Palczewski K. PMID: 12716426; PMCID: PMC1435694.
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Ligand channeling within a G-protein-coupled receptor. The entry and exit of retinals in native opsin. J Biol Chem. 2003 Jul 04; 278(27):24896-24903. Schädel SA, Heck M, Maretzki D, Filipek S, Teller DC, Palczewski K, Hofmann KP. PMID: 12707280; PMCID: PMC1360283.
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Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem. 2003 Jun 13; 278(24):21655-21662. Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A. PMID: 12663652; PMCID: PMC1360145.
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Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry. 2003 Mar 18; 42(10):2759-67. Mirzadegan T, Benkö G, Filipek S, Palczewski K. PMID: 12627940; PMCID: PMC1435692.
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Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2290-5. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP, Ernst OP. PMID: 12601165; PMCID: PMC151333.
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The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors. Annu Rev Biophys Biomol Struct. 2003; 32:375-97. Filipek S, Teller DC, Palczewski K, Stenkamp R. PMID: 12574068; PMCID: PMC1351250.
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Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa. J Biol Chem. 2003 Apr 18; 278(16):14442-14450. Noorwez SM, Kuksa V, Imanishi Y, Zhu L, Filipek S, Palczewski K, Kaushal S. PMID: 12566452; PMCID: PMC1361689.
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Atomic-force microscopy: Rhodopsin dimers in native disc membranes. Nature. 2003 Jan 09; 421(6919):127-8. Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K. PMID: 12520290.
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Photoreceptor guanylate cyclase variants: cGMP production under control. Acta Biochim Pol. 2003; 50(4):1075-95. Sokal I, Alekseev A, Palczewski K. PMID: 14739996; PMCID: PMC1351243.
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Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 07; 278(10):8316-25. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. PMID: 12499365.
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Signaling states of rhodopsin. Formation of the storage form, metarhodopsin III, from active metarhodopsin II. J Biol Chem. 2003 Jan 31; 278(5):3162-9. Heck M, Schädel SA, Maretzki D, Bartl FJ, Ritter E, Palczewski K, Hofmann KP. PMID: 12427735; PMCID: PMC1364529.
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Crystal structure of rhodopsin: a template for cone visual pigments and other G protein-coupled receptors. Biochim Biophys Acta. 2002 Oct 11; 1565(2):168-82. Stenkamp RE, Filipek S, Driessen CA, Teller DC, Palczewski K. PMID: 12409193.
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Crystal structure of rhodopsin: a G-protein-coupled receptor. Chembiochem. 2002 Oct 04; 3(10):963-7. Stenkamp RE, Teller DC, Palczewski K. PMID: 12362360.
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Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. J Biol Chem. 2002 Nov 22; 277(47):45537-45546. Haeseleer F, Jang GF, Imanishi Y, Driessen CAGG, Matsumura M, Nelson PS, Palczewski K. PMID: 12226107; PMCID: PMC1435693.
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Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals. J Biol Chem. 2002 Nov 01; 277(44):42315-42324. Kuksa V, Bartl F, Maeda T, Jang GF, Ritter E, Heck M, Preston Van Hooser J, Liang Y, Filipek S, Gelb MH, Hofmann KP, Palczewski K. PMID: 12176994; PMCID: PMC1363677.
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Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. Eur J Immunol. 2002 Aug; 32(8):2300-7. Maeda A, Maeda T, Ohguro H, Palczewski K, Sato N. PMID: 12209643.
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Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7711-6. Yang J, McBride S, Mak DO, Vardi N, Palczewski K, Haeseleer F, Foskett JK. PMID: 12032348; PMCID: PMC124329.
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G protein-coupled receptor rhodopsin: a prospectus. Annu Rev Physiol. 2003; 65:851-79. Filipek S, Stenkamp RE, Teller DC, Palczewski K. PMID: 12471166; PMCID: PMC1435697.
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GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J. 2002 Apr 02; 21(7):1545-54. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W. PMID: 11927539; PMCID: PMC125366.
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Recovery of visual functions in a mouse model of Leber congenital amaurosis. J Biol Chem. 2002 May 24; 277(21):19173-82. Van Hooser JP, Liang Y, Maeda T, Kuksa V, Jang GF, He YG, Rieke F, Fong HK, Detwiler PB, Palczewski K. PMID: 11897783; PMCID: PMC1470660.
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Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1. Nat Neurosci. 2002 Mar; 5(3):210-7. Lee A, Westenbroek RE, Haeseleer F, Palczewski K, Scheuer T, Catterall WA. PMID: 11865310; PMCID: PMC1435861.
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Calcium-binding proteins: intracellular sensors from the calmodulin superfamily. Biochem Biophys Res Commun. 2002 Jan 18; 290(2):615-23. Haeseleer F, Imanishi Y, Sokal I, Filipek S, Palczewski K. PMID: 11785943.
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Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry. 2002 Jan 08; 41(1):251-7. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K. PMID: 11772023; PMCID: PMC1363675.
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Crystal Structure of Rhodopsin: Implication for Vision and Beyond. Mechanisms of Acti. ScientificWorldJournal. 2002; 2:106-107. Palczewski K. PMID: 29973825; PMCID: PMC6009445.
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Rhodopsin and its kinase. Methods Enzymol. 2002; 343:578-600. Sokal I, Pulvermüller A, Buczylko J, Hofmann KP, Palczewski K. PMID: 11665593; PMCID: PMC1363672.
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Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme. Adv Exp Med Biol. 2002; 514:303-17. Haeseleer F, Palczewski K. PMID: 12596929.
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Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. PMID: 11860507; PMCID: PMC1363676.
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Gene transfer mediated by recombinant baculovirus into mouse eye. Invest Ophthalmol Vis Sci. 2001 Dec; 42(13):3294-300. Haeseleer F, Imanishi Y, Saperstein DA, Palczewski K. PMID: 11726636; PMCID: PMC1436034.
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Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo. J Biol Chem. 2001 Dec 21; 276(51):48483-93. McBee JK, Van Hooser JP, Jang GF, Palczewski K. PMID: 11604395; PMCID: PMC1409735.
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G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr Opin Drug Discov Devel. 2001 Sep; 4(5):561-74. Ballesteros J, Palczewski K. PMID: 12825452; PMCID: PMC1383658.
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Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem. 2001 Nov 16; 276(46):43361-73. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K. PMID: 11524415; PMCID: PMC1363678.
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Crystal structure of rhodopsin: implications for vision and beyond. Curr Opin Struct Biol. 2001 Aug; 11(4):420-6. Okada T, Palczewski K. PMID: 11495733.
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Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem. 2001 Aug; 382(8):1179-88. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W. PMID: 11592399.
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Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry. 2001 Jul 03; 40(26):7761-72. Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE. PMID: 11425302; PMCID: PMC1698954.
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Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001 Jul; 20(4):469-529. McBee JK, Palczewski K, Baehr W, Pepperberg DR. PMID: 11390257.
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Characterization of a dehydrogenase activity responsible for oxidation of 11-cis-retinol in the retinal pigment epithelium of mice with a disrupted RDH5 gene. A model for the human hereditary disease fundus albipunctatus. J Biol Chem. 2001 Aug 31; 276(35):32456-65. Jang GF, Van Hooser JP, Kuksa V, McBee JK, He YG, Janssen JJ, Driessen CA, Palczewski K. PMID: 11418621; PMCID: PMC1361690.
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Activation of rhodopsin: new insights from structural and biochemical studies. Trends Biochem Sci. 2001 May; 26(5):318-24. Okada T, Ernst OP, Palczewski K, Hofmann KP. PMID: 11343925.
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Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein. J Biol Chem. 2001 Jul 13; 276(28):26148-53. Jang GF, Kuksa V, Filipek S, Bartl F, Ritter E, Gelb MH, Hofmann KP, Palczewski K. PMID: 11316815; PMCID: PMC1361691.
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Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22; 276(25):22287-95. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. PMID: 11292825; PMCID: PMC1364467.
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Cloning and characterization of a human beta,beta-carotene-15,15'-dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics. 2001 Mar 01; 72(2):193-202. Yan W, Jang GF, Haeseleer F, Esumi N, Chang J, Kerrigan M, Campochiaro M, Campochiaro P, Palczewski K, Zack DJ. PMID: 11401432.
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Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung. Mol Cell Endocrinol. 2001 Jan 22; 171(1-2):111-7. Brereton P, Suzuki T, Sasano H, Li K, Duarte C, Obeyesekere V, Haeseleer F, Palczewski K, Smith I, Komesaroff P, Krozowski Z. PMID: 11165019.
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Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta. 2000 Dec 20; 1498(2-3):233-51. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K. PMID: 11108966.
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Light-induced conformational changes of rhodopsin probed by fluorescent alexa594 immobilized on the cytoplasmic surface. Biochemistry. 2000 Dec 12; 39(49):15225-33. Imamoto Y, Kataoka M, Tokunaga F, Palczewski K. PMID: 11106502; PMCID: PMC1382172.
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Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins. Biochemistry. 2000 Sep 19; 39(37):11370-80. McBee JK, Kuksa V, Alvarez R, de Lera AR, Prezhdo O, Haeseleer F, Sokal I, Palczewski K. PMID: 10985782; PMCID: PMC1408314.
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Stereoisomeric specificity of the retinoid cycle in the vertebrate retina. J Biol Chem. 2000 Sep 08; 275(36):28128-38. Jang GF, McBee JK, Alekseev AM, Haeseleer F, Palczewski K. PMID: 10871622; PMCID: PMC1435698.
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Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Vis Neurosci. 2000 Sep-Oct; 17(5):667-678. Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang GF, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K. PMID: 11153648; PMCID: PMC1410813.
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Crystal structure of rhodopsin: A G protein-coupled receptor. Science. 2000 Aug 04; 289(5480):739-45. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE, Yamamoto M, Miyano M. PMID: 10926528.
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Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness. Proc Natl Acad Sci U S A. 2000 Jul 18; 97(15):8623-8. Van Hooser JP, Aleman TS, He YG, Cideciyan AV, Kuksa V, Pittler SJ, Stone EM, Jacobson SG, Palczewski K. PMID: 10869443; PMCID: PMC26998.
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Disruption of the 11-cis-retinol dehydrogenase gene leads to accumulation of cis-retinols and cis-retinyl esters. Mol Cell Biol. 2000 Jun; 20(12):4275-87. Driessen CA, Winkens HJ, Hoffmann K, Kuhlmann LD, Janssen BP, Van Vugt AH, Van Hooser JP, Wieringa BE, Deutman AF, Palczewski K, Ruether K, Janssen JJ. PMID: 10825191; PMCID: PMC85795.
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The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):5901-6. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, Maizels ET, Bader MF, Kahn RA, Palczewski K, Aktories K, Hunzicker-Dunn M. PMID: 10811902; PMCID: PMC18531.
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X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J Struct Biol. 2000 May; 130(1):73-80. Okada T, Le Trong I, Fox BA, Behnke CA, Stenkamp RE, Palczewski K. PMID: 10806093.
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Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. Bioessays. 2000 Apr; 22(4):337-50. Palczewski K, Polans AS, Baehr W, Ames JB. PMID: 10723031.
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Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000 Jan 14; 275(2):1247-60. Haeseleer F, Sokal I, Verlinde CL, Erdjument-Bromage H, Tempst P, Pronin AN, Benovic JL, Fariss RN, Palczewski K. PMID: 10625670; PMCID: PMC1364469.
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Multienzyme analysis of visual cycle. Methods Enzymol. 2000; 316:330-44. Stecher H, Palczewski K. PMID: 10800685; PMCID: PMC1560099.
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Phase partition and high-performance liquid chromatography assays of retinoid dehydrogenases. Methods Enzymol. 2000; 316:359-71. Saari JC, Garwin GG, Haeseleer F, Jang GF, Palczewski K. PMID: 10800687; PMCID: PMC1552099.
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Short-chain dehydrogenases/reductases in retina. Methods Enzymol. 2000; 316:372-83. Haeseleer F, Palczewski K. PMID: 10800688.
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Structural analysis of protein prenyl groups and associated C-terminal modifications. Methods Enzymol. 2000; 316:436-51. Whitten ME, Yokoyama K, Schieltz D, Ghomashchi F, Lam D, Yates JR, Palczewski K, Gelb MH. PMID: 10800693; PMCID: PMC1435690.
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Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. PMID: 10564809.
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Isomerization of all-trans-9- and 13-desmethylretinol by retinal pigment epithelial cells. Biochemistry. 1999 Oct 12; 38(41):13542-50. Stecher H, Prezhdo O, Das J, Crouch RK, Palczewski K. PMID: 10521261.
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Kinetics of visual pigment regeneration in excised mouse eyes and in mice with a targeted disruption of the gene encoding interphotoreceptor retinoid-binding protein or arrestin. Biochemistry. 1999 Sep 14; 38(37):12012-9. Palczewski K, Van Hooser JP, Garwin GG, Chen J, Liou GI, Saari JC. PMID: 10508404.
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Conformational changes in guanylyl cyclase-activating protein 1 (GCAP1) and its tryptophan mutants as a function of calcium concentration. J Biol Chem. 1999 Jul 09; 274(28):19829-37. Sokal I, Otto-Bruc AE, Surgucheva I, Verlinde CL, Wang CK, Baehr W, Palczewski K. PMID: 10391927.
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A novel form of rhodopsin kinase from chicken retina and pineal gland. FEBS Lett. 1999 Jul 02; 454(1-2):115-21. Zhao X, Yokoyama K, Whitten ME, Huang J, Gelb MH, Palczewski K. PMID: 10413107.
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Three-dimensional structure of guanylyl cyclase activating protein-2, a calcium-sensitive modulator of photoreceptor guanylyl cyclases. J Biol Chem. 1999 Jul 02; 274(27):19329-37. Ames JB, Dizhoor AM, Ikura M, Palczewski K, Stryer L. PMID: 10383444.
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beta-arrestin-dependent desensitization of luteinizing hormone/choriogonadotropin receptor is prevented by a synthetic peptide corresponding to the third intracellular loop of the receptor. J Biol Chem. 1999 May 07; 274(19):12984-9. Mukherjee S, Palczewski K, Gurevich VV, Hunzicker-Dunn M. PMID: 10224047.
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Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein. J Biol Chem. 1999 Mar 26; 274(13):8577-85. Stecher H, Gelb MH, Saari JC, Palczewski K. PMID: 10085092.
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Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem. 1999 Mar 05; 274(10):6526-35. Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K. PMID: 10037746.
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Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry. 1999 Mar 02; 38(9):2611-6. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP. PMID: 10052930.
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Identification of a guanylyl cyclase-activating protein-binding site within the catalytic domain of retinal guanylyl cyclase 1. Biochemistry. 1999 Feb 02; 38(5):1387-93. Sokal I, Haeseleer F, Arendt A, Adman ET, Hargrave PA, Palczewski K. PMID: 9931003.
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A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):493-8. Mukherjee S, Palczewski K, Gurevich V, Benovic JL, Banga JP, Hunzicker-Dunn M. PMID: 9892661; PMCID: PMC15164.
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Molecular mechanism of visual transduction. Novartis Found Symp. 1999; 224:191-204; discussion 204-7. Palczewski K, Verlinde CL, Haeseleer F. PMID: 10614052.
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Phosphorylation of photolyzed rhodopsin is calcium-insensitive in retina permeabilized by alpha-toxin. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):15014-9. Otto-Bruc AE, Fariss RN, Van Hooser JP, Palczewski K. PMID: 9844007; PMCID: PMC24567.
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Identification of a single phosphorylation site within octopus rhodopsin. Photochem Photobiol. 1998 Dec; 68(6):824-8. Ohguro H, Yoshida N, Shindou H, Crabb JW, Palczewski K, Tsuda M. PMID: 9867032.
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Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21; 273(34):21790-9. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K. PMID: 9705317.
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GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell. 1998 Jul; 2(1):129-33. Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K. PMID: 9702199.
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Reduction of all-trans-retinal limits regeneration of visual pigment in mice. Vision Res. 1998 May; 38(10):1325-33. Saari JC, Garwin GG, Van Hooser JP, Palczewski K. PMID: 9667000.
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Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci. 1998 May 01; 18(9):3195-205. Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV. PMID: 9547228; PMCID: PMC6792646.
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High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. PMID: 9560279; PMCID: PMC20264.
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Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem. 1998 Mar 15; 252(3):591-9. Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W. PMID: 9546678.
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Molecular forms of human rhodopsin kinase (GRK1). J Biol Chem. 1998 Feb 27; 273(9):5124-31. Zhao X, Huang J, Khani SC, Palczewski K. PMID: 9478965.
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A null mutation in the photoreceptor guanylate cyclase gene causes the retinal degeneration chicken phenotype. Proc Natl Acad Sci U S A. 1998 Feb 03; 95(3):1271-6. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W. PMID: 9448321; PMCID: PMC18742.
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Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proc Natl Acad Sci U S A. 1998 Jan 06; 95(1):328-33. Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. PMID: 9419375; PMCID: PMC18214.
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Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry. 1998 Jan 06; 37(1):248-57. Rudnicka-Nawrot M, Surgucheva I, Hulmes JD, Haeseleer F, Sokal I, Crabb JW, Baehr W, Palczewski K. PMID: 9425045.
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Calcium binding to recoverin: implications for secondary structure and membrane association. Biochim Biophys Acta. 1997 Oct 17; 1342(2):164-74. Johnson WC, Palczewski K, Gorczyca WA, Riazance-Lawrence JH, Witkowska D, Polans AS. PMID: 9392525.
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GTP-binding-protein-coupled receptor kinases--two mechanistic models. Eur J Biochem. 1997 Sep 01; 248(2):261-9. Palczewski K. PMID: 9346277.
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Activation and inactivation steps in the visual transduction pathway. Curr Opin Neurobiol. 1997 Aug; 7(4):500-4. Palczewski K, Saari JC. PMID: 9287193.
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Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin. Biochemistry. 1997 Jul 29; 36(30):9253-60. Pulvermüller A, Maretzki D, Rudnicka-Nawrot M, Smith WC, Palczewski K, Hofmann KP. PMID: 9230059.
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Localization of guanylate cyclase-activating protein 2 in mammalian retinas. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4727-32. Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczylko J, Surgucheva I, Baehr W, Milam AH, Palczewski K. PMID: 9114059; PMCID: PMC20792.
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Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry. 1997 Apr 08; 36(14):4295-302. Otto-Bruc A, Buczylko J, Surgucheva I, Subbaraya I, Rudnicka-Nawrot M, Crabb JW, Arendt A, Hargrave PA, Baehr W, Palczewski K. PMID: 9100025.
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Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis Neurosci. 1997 Mar-Apr; 14(2):225-32. Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K. PMID: 9147475.
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The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics. 1997 Feb 01; 39(3):312-22. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W. PMID: 9119368.
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Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci. 1996 Dec; 19(12):547-54. Polans A, Baehr W, Palczewski K. PMID: 8961484.
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Splice variants of arrestins. Exp Eye Res. 1996 Nov; 63(5):599-602. Palczewski K, Smith WC. PMID: 8994364.
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Mechanisms of opsin activation. J Biol Chem. 1996 Aug 23; 271(34):20621-30. Buczylko J, Saari JC, Crouch RK, Palczewski K. PMID: 8702809.
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Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry. 1996 Jul 02; 35(26):8478-82. Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K, Sitaramayya A, Baehr W, Sharma RK. PMID: 8679607.
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Responses of the phototransduction cascade to dim light. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4677-82. Langlois G, Chen CK, Palczewski K, Hurley JB, Vuong TM. PMID: 8643463; PMCID: PMC39338.
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Expression of GCAP1 and GCAP2 in the retinal degeneration (rd) mutant chicken retina. FEBS Lett. 1996 Apr 29; 385(1-2):47-52. Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W. PMID: 8641465.
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Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry. 1996 Mar 05; 35(9):2901-8. Jäger S, Palczewski K, Hofmann KP. PMID: 8608127.
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Structural and enzymatic aspects of rhodopsin phosphorylation. J Biol Chem. 1996 Mar 01; 271(9):5215-24. Ohguro H, Rudnicka-Nawrot M, Buczylko J, Zhao X, Taylor JA, Walsh KA, Palczewski K. PMID: 8617805.
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Alligator rhodopsin: sequence and biochemical properties. Exp Eye Res. 1995 Nov; 61(5):569-78. Smith WC, Adamus G, Van Der Wel H, Timmers A, Palczewski K, Ulshafer RJ, Hargrave PA, McDowell JH. PMID: 8654500.
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Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem. 1995 Sep 15; 270(37):22029-36. Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K. PMID: 7665624.
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Mechanism of rhodopsin phosphorylation. Biophys Chem. 1995 Sep-Oct; 56(1-2):183-8. Zhao X, Palczewski K, Ohguro H. PMID: 7662865.
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Separation of phospho- and non-phosphopeptides using reverse phase column chromatography. FEBS Lett. 1995 Jul 24; 368(3):452-4. Ohguro H, Palczewski K. PMID: 7635197.
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Rhodopsin kinase autophosphorylation. Characterization of site-specific mutations. J Biol Chem. 1995 Jun 23; 270(25):15294-8. Palczewski K, Ohguro H, Premont RT, Inglese J. PMID: 7797516.
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Rhodopsin phosphorylation and dephosphorylation in vivo. J Biol Chem. 1995 Jun 16; 270(24):14259-62. Ohguro H, Van Hooser JP, Milam AH, Palczewski K. PMID: 7782279.
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Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome. 1995 Feb; 6(2):142-4. Kozak CA, Danciger M, Bowes C, Adamson MC, Palczewski K, Polans AS, Farber DB. PMID: 7767000.
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Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem. 1994 Dec 09; 269(49):31080-9. Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W. PMID: 7983048.
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Topographic study of arrestin using differential chemical modifications and hydrogen/deuterium exchange. Protein Sci. 1994 Dec; 3(12):2428-34. Ohguro H, Palczewski K, Walsh KA, Johnson RS. PMID: 7756996; PMCID: PMC2142757.
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Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction. Biochemistry. 1994 Nov 22; 33(46):13741-50. Palczewski K, Jäger S, Buczylko J, Crouch RK, Bredberg DL, Hofmann KP, Asson-Batres MA, Saari JC. PMID: 7947785.
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Inositolhexakisphosphate (InsP6): an antagonist of fibroblast growth factor receptor binding and activity. In Vitro Cell Dev Biol Anim. 1994 Nov; 30A(11):783-9. Morrison RS, Shi E, Kan M, Yamaguchi F, McKeehan W, Rudnicka-Nawrot M, Palczewski K. PMID: 7881632.
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Structure and functions of arrestins. Protein Sci. 1994 Sep; 3(9):1355-61. Palczewski K. PMID: 7833798; PMCID: PMC2142942.
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Is vertebrate phototransduction solved? New insights into the molecular mechanism of phototransduction. Invest Ophthalmol Vis Sci. 1994 Sep; 35(10):3577-81. Palczewski K. PMID: 7522225.
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Heterogeneous N-acylation is a tissue- and species-specific posttranslational modification. J Biol Chem. 1994 Aug 19; 269(33):21067-71. Johnson RS, Ohguro H, Palczewski K, Hurley JB, Walsh KA, Neubert TA. PMID: 8063726.
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Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein. Neuron. 1994 Aug; 13(2):395-404. Palczewski K, Subbaraya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, et al. PMID: 7520254.
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Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5411-5. Robinson PR, Buczylko J, Ohguro H, Palczewski K. PMID: 8202499; PMCID: PMC44005.
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A splice variant of arrestin. Molecular cloning and localization in bovine retina. J Biol Chem. 1994 Jun 03; 269(22):15407-10. Smith WC, Milam AH, Dugger D, Arendt A, Hargrave PA, Palczewski K. PMID: 7515057.
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Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):4014-8. Gorczyca WA, Gray-Keller MP, Detwiler PB, Palczewski K. PMID: 7909609; PMCID: PMC43713.
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Nucleotide inhibitors and activators of retinal guanylyl cyclase. Biochemistry. 1994 Mar 22; 33(11):3217-22. Gorczyca WA, Van Hooser JP, Palczewski K. PMID: 7511001.
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Purification and primary structure of Capl, an S-100-related calcium-binding protein isolated from bovine retina. J Biol Chem. 1994 Feb 25; 269(8):6233-40. Polans AS, Palczewski K, Asson-Batres MA, Ohguro H, Witkowska D, Haley TL, Baizer L, Crabb JW. PMID: 8119967.
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Characterization of a truncated form of arrestin isolated from bovine rod outer segments. Protein Sci. 1994 Feb; 3(2):314-24. Palczewski K, Buczylko J, Ohguro H, Annan RS, Carr SA, Crabb JW, Kaplan MW, Johnson RS, Walsh KA. PMID: 8003967; PMCID: PMC2142797.
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Control of rhodopsin multiple phosphorylation. Biochemistry. 1994 Feb 01; 33(4):1023-8. Ohguro H, Johnson RS, Ericsson LH, Walsh KA, Palczewski K. PMID: 8305429.
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Interaction between photoactivated rhodopsin and its kinase: stability and kinetics of complex formation. Biochemistry. 1993 Dec 28; 32(51):14082-8. Pulvermüller A, Palczewski K, Hofmann KP. PMID: 8260489.
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Assays of retinoid dehydrogenases by phase partition. Anal Biochem. 1993 Aug 15; 213(1):128-32. Saari JC, Bredberg DL, Garwin GG, Buczylko J, Wheeler T, Palczewski K. PMID: 8238865.
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The kinetics of multiphosphorylation of rhodopsin. Arch Biochem Biophys. 1993 Aug 01; 304(2):443-7. Adamus G, Arendt A, Hargrave PA, Heyduk T, Palczewski K. PMID: 8346919.
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Sequential phosphorylation of rhodopsin at multiple sites. Biochemistry. 1993 Jun 01; 32(21):5718-24. Ohguro H, Palczewski K, Ericsson LH, Walsh KA, Johnson RS. PMID: 8504090.
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Beta-arrestin and arrestin are recognized by autoantibodies in sera from multiple sclerosis patients. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3241-5. Ohguro H, Chiba S, Igarashi Y, Matsumoto H, Akino T, Palczewski K. PMID: 8475065; PMCID: PMC46275.
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Basic fibroblast growth factor expression is required for clonogenic growth of human glioma cells. J Neurosci Res. 1993 Apr 01; 34(5):502-9. Morrison RS, Giordano S, Yamaguchi F, Hendrickson S, Berger MS, Palczewski K. PMID: 8478985.
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Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin. J Biol Chem. 1993 Mar 15; 268(8):6004-13. Palczewski K, Buczylko J, Lebioda L, Crabb JW, Polans AS. PMID: 8383684.
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The effect of recoverin-like calcium-binding proteins on the photoresponse of retinal rods. Neuron. 1993 Mar; 10(3):523-31. Gray-Keller MP, Polans AS, Palczewski K, Detwiler PB. PMID: 8461139.
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Recoverin, but not visinin, is an autoantigen in the human retina identified with a cancer-associated retinopathy. Invest Ophthalmol Vis Sci. 1993 Jan; 34(1):81-90. Polans AS, Burton MD, Haley TL, Crabb JW, Palczewski K. PMID: 8425844.
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Identification of the autophosphorylation sites in rhodopsin kinase. J Biol Chem. 1992 Sep 15; 267(26):18991-8. Palczewski K, Buczylko J, Van Hooser P, Carr SA, Huddleston MJ, Crabb JW. PMID: 1527025.
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The role of arrestin and retinoids in the regeneration pathway of rhodopsin. J Biol Chem. 1992 Aug 05; 267(22):15701-6. Hofmann KP, Pulvermüller A, Buczylko J, Van Hooser P, Palczewski K. PMID: 1386362.
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Structural properties of arrestin studied by chemical modification and circular dichroism. Biochemistry. 1992 Apr 28; 31(16):3902-6. Palczewski K, Riazance-Lawrence JH, Johnson WC. PMID: 1567843.
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The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction. Neuron. 1992 Jan; 8(1):117-26. Palczewski K, Rispoli G, Detwiler PB. PMID: 1309646.
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Binding of inositol phosphates to arrestin. FEBS Lett. 1991 Dec 16; 295(1-3):195-9. Palczewski K, Pulvermüller A, Buczylko J, Gutmann C, Hofmann KP. PMID: 1765153.
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Phosphorylated rhodopsin and heparin induce similar conformational changes in arrestin. J Biol Chem. 1991 Oct 05; 266(28):18649-54. Palczewski K, Pulvermüller A, Buczylko J, Hofmann KP. PMID: 1917988.
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G-protein-coupled receptor kinases. Trends Biochem Sci. 1991 Oct; 16(10):387-91. Palczewski K, Benovic JL. PMID: 1664548.
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proc Natl Acad Sci U S A. 1991 Oct 01; 88(19):8715-9. Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. PMID: 1656454; PMCID: PMC52580.
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Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin. J Biol Chem. 1991 Aug 15; 266(23):15334-9. Palczewski K, Buczylko J, Imami NR, McDowell JH, Hargrave PA. PMID: 1651326.
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Mechanism of rhodopsin kinase activation. J Biol Chem. 1991 Jul 15; 266(20):12949-55. Palczewski K, Buczylko J, Kaplan MW, Polans AS, Crabb JW. PMID: 2071581.
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Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain. Pharmacol Res. 1991 Jul; 24(1):15-23. Ragazzi E, Shryock J, Palczewski K. PMID: 1946140.
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Elevated level of protein phosphatase 2A activity in retinas of rd mice. Exp Eye Res. 1991 Jul; 53(1):101-5. Palczewski K, Farber DB, Hargrave PA. PMID: 1652453.
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Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase. Biochemistry. 1991 May 28; 30(21):5118-25. Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. PMID: 1645191.
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Regulation of rhodopsin kinase by autophosphorylation. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2568-72. Buczylko J, Gutmann C, Palczewski K. PMID: 2006192; PMCID: PMC51274.
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Studies of ligand binding to arrestin. J Biol Chem. 1991 Mar 05; 266(7):4201-6. Palczewski K, Hargrave PA. PMID: 1999413.
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A photoreceptor calcium binding protein is recognized by autoantibodies obtained from patients with cancer-associated retinopathy. J Cell Biol. 1991 Mar; 112(5):981-9. Polans AS, Buczylko J, Crabb J, Palczewski K. PMID: 1999465; PMCID: PMC2288874.
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Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res. 1991; 31(1):17-31. Adamus G, Zam ZS, Arendt A, Palczewski K, McDowell JH, Hargrave PA. PMID: 2006550.
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Phosphorylation of iodopsin, chicken red-sensitive cone visual pigment. Biochemistry. 1990 Oct 30; 29(43):10102-6. Fukada Y, Kokame K, Okano T, Shichida Y, Yoshizawa T, McDowell JH, Hargrave PA, Palczewski K. PMID: 2271641.
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Nucleoside inhibitors of rhodopsin kinase. Biochemistry. 1990 Jul 03; 29(26):6276-82. Palczewski K, Kahn N, Hargrave PA. PMID: 2207073.
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X-ray crystal structure of sangivamycin, a potent inhibitor of protein kinases. FEBS Lett. 1990 Jun 18; 266(1-2):102-4. Lebioda L, Hargrave PA, Palczewski K. PMID: 2365059.
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Synthetic phosphopeptides are substrates for casein kinase II. FEBS Lett. 1990 Feb 12; 261(1):117-20. Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. PMID: 2307228.
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Molecular, enzymatic and functional properties of rhodopsin kinase from rat pineal gland. Vision Res. 1990; 30(8):1129-37. Palczewski K, Carruth ME, Adamus G, McDowell JH, Hargrave PA. PMID: 2402884.
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Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations. Biochemistry. 1989 Oct 31; 28(22):8764-70. Palczewski K, Arendt A, McDowell JH, Hargrave PA. PMID: 2605220.
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Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem. 1989 Sep 25; 264(27):15770-3. Palczewski K, McDowell JH, Jakes S, Ingebritsen TS, Hargrave PA. PMID: 2550422.
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Synthesis of phosphopeptides containing O-phosphoserine or O-phosphothreonine. Int J Pept Protein Res. 1989 Jun; 33(6):468-76. Arendt A, Palczewski K, Moore WT, Caprioli RM, McDowell JH, Hargrave PA. PMID: 2506143.
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The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin. Biochemistry. 1989 Jan 24; 28(2):415-9. Palczewski K, Hargrave PA, McDowell JH, Ingebritsen TS. PMID: 2540796.
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Purification and characterization of rhodopsin kinase. J Biol Chem. 1988 Oct 05; 263(28):14067-73. Palczewski K, McDowell JH, Hargrave PA. PMID: 2844754.
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Rhodopsin kinase: substrate specificity and factors that influence activity. Biochemistry. 1988 Apr 05; 27(7):2306-13. Palczewski K, McDowell JH, Hargrave PA. PMID: 3382623.
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Photoaffinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 8-azido-1,N6-ethenoadenosine 5'-triphosphate. Biochemistry. 1987 Jun 16; 26(12):3466-71. Palczewski K, Kochman M. PMID: 3651392.
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Affinity labeling of rabbit muscle fructose-1,6-bisphosphate aldolase with 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Eur J Biochem. 1985 Jan 15; 146(2):309-14. Palczewski K, Hargrave PA, Folta EJ, Kochman M. PMID: 3967660.
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o-Phthalaldehyde, a fluorescence probe of aldolase active site. Eur J Biochem. 1983 Dec 15; 137(3):429-35. Palczewski K, Hargrave PA, Kochman M. PMID: 6662105.
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